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Описание

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Экзифин таб., 250 мг, 16 шт.

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Коротко о товаре

Артикул Маркета
3184015088
Тип препарата
Назначение
Действующее вещество
Возраст
от 2 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"3476425530867931471":{"specItems":[{"name":"Артикул Маркета","value":"3184015088","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"дерматофития гладкой кожи тела, кандидоз, микоз волосистой части головы, микоз кожи, микроспория, онихомикозы, трихофития","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["36476390:36618650,36618609,36618562,36618136,36617979,36617545,36617373"]}}},{"name":"действующее вещество","value":"Тербинафин","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["27144131:28709156"]}}},{"name":"возраст","value":"от 2 лет"},{"name":"форма выпуска","value":"таблетки"},{"name":"страна-производитель","value":"Индия"}]}},"compactSpecs":{"3476425530867931471":{"specItems":[{"name":"Артикул Маркета","value":"3184015088","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Действующее вещество","value":"Тербинафин","transition":{"type":"list","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["27144131:28709156"]}}},{"name":"Возраст","value":"От 2 лет"},{"name":"Форма выпуска","value":"Таблетки"}]}},"fullSpecs":{"3476425530867931471":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["27272850:1,0"]}}},{"name":"Органы и системы","value":"кожа","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["34045610:34516012"]}}},{"name":"Назначение","value":"дерматофития гладкой кожи тела, кандидоз, микоз волосистой части головы, микоз кожи, микроспория, онихомикозы, трихофития","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["36476390:36618650,36618609,36618562,36618136,36617979,36617545,36617373"]}}},{"name":"Показания к применению","value":"- Микозы волосистой части головы (трихофития, микроспория).\u003Cbr\u003E- Микозы кожи и ногтей, обусловленные Trx chophvton (Т. rubrum. mentagrophytes. verrucosum, violaceum). Microsporum (M. canis, M. gypseum) u Epidennophytom floccosum.\u003Cbr\u003E- Онихомикозы.\u003Cbr\u003E- Тяжёлые. распространённые дерматомикозы гладкой кожи туловища и конечностей, требующие системного лечения.\u003Cbr\u003E- Кандидозы кожи и слизистых оболочек."},{"name":"Противопоказания","value":"Повышенная чувствительность к какому-либо компоненту препарата: детский возраст до 2 лет, т.к. нет достаточного количества данных о применении препарат детьми с массой тела менее 12 кг, беременность, период кормления грудью."},{"name":"Состав","value":"Каждая таблетка содержит:\u003Cbr\u003EАктивное вещество: тербинафина гидрохлорид 281,31 мг (в пересчете на 250 мг тербинафина).\u003Cbr\u003EВспомогательные вещества: целлюлоза микрокристаллическая, натрия гликолат крахмальный, крахмал прежелатинизированный, магния стеарат, кремний коллоидный безводный."},{"name":"Действующее вещество","value":"Тербинафин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["27144131:28709156"]}}},{"name":"Способ применения и дозы","value":"Длительность курса лечения и режим дозирования устанавливается в индивидуальном порядке и зависит от локализации процесса и тяжести заболевания.\u003Cbr\u003EВзрослым:\u003Cbr\u003EОбычная доза: 250 мг (1 таблетка) 1 раз в день.\u003Cbr\u003EОнихомикозы: Продолжительность терапии около 6-12 недель, При поражении ногтей пальцев кистей и стоп (за исключением большого пальца стопы), или при молодом возрасте больного длительность лечение может быть менее 12 недель. При инфекции большого пальца стопы 3-месячный курс лечения обычно достаточен. В редких случаях, при замедленной скорости роста ногтей, может потребоваться более длительное лечение до 6 и более месяцев.\u003Cbr\u003EГрибковые инфекции кожи: Продолжительность лечения при межпальцевой, подошвенной или по типу \"носков\" локализации инфекции составляет 2-6 нед.. при микозах других участков тела: голеней - 2-4 нед.. туловища - 4 нед.: при микозах, вызванных Candida. 2-4 нед.;\u003Cbr\u003Eпри микозах головы, вызванных Microsporum canis - более 4 нед.\u003Cbr\u003EДетям: обычно назначают 125 мг (1/2 таблетки). Продолжительность лечения микозов волосистой части головы около 4-х недель, при заражении Microsporum canis - может быть более длительной.\u003Cbr\u003EПри массе тела менее 20 кг - 62.5 мг (1/4 таблетки) 1 раз в сутки.\u003Cbr\u003EПри массе тела 20 до 40 кг - 125 мг (1/2 таблетки) 1 раз в сутки.\u003Cbr\u003EПри массе более 40 кг - 250 мг (1 таблетка)! раз в сутки.\u003Cbr\u003EПожилым больным препарат назначают в тех же дозах, что и взрослым.\u003Cbr\u003EПри выраженных нарушениях функции печени и/или ночек (клиренс креатинина \u003C 50 мл/мин либо концентрация креатинина в крови более 300 мкмоль/л): 125 мг 1 раз в день."},{"name":"Побочные действия","value":"Побочные действия обычно средней и лёгкой степени тяжести и носят временный характер. Часто встречающиеся побочные действия со стороны органов системы пищеварения: чувство переполненного желудка, диспепсия, тошнота, потеря аппетита, боли в животе, диарея, не часто - нарушение вкусовою восприятия, в г.ч. потеря его, которая восстанавливается через несколько недель после прекращения лечения; редко - холестаз. желтуха, гепатит, бессимптомное увеличение уровня трансаминаз печени. Не смотря на недоказанность причинной связи них нарушений с приёмом тербинафина. в случае развития гепатобилиарной дисфункции лечение Экзифином следует прекратить.\u003Cbr\u003EСо стороны ПНС: редко - парестезия, гипостезия, головокружение, очень редко депрессия, чувство повышенной тревоги.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: часто артралгия. миалгия.\u003Cbr\u003EСо стороны системы кроветворения: очень редко нейтропения, агранулоцитоз, тромбоцитопения.\u003Cbr\u003EСо стороны иммунной системы: часто крапивница, многоформная -эритема, редко системные аллергические реакции (реакции подобные сывороточной болезни, аш модема). очень редко тяжёлые кожные реакции (токсический эпидермальный некролиз. синдром Стивенса-Джонсона. фоточувствительность). При прогрессировании кожных высыпаний течение тербинафином следует прекратить. Прочие: часто головная боль, плохое самочувствие, чувство усталости, очень редко - экзацербация псориаза, усиленное выпадение волос."},{"name":"Фармакологическое действие","value":"Тербинафин относится к группе аллиламинов, обладает широким спектром противогрибкового действия. В низких концентрациях оказывает фунгицидное действие на дерматофиты Trychophyton (Т. rubrum, Т. mentagrophytes, Т. tonsurans, Т. verrucosum, T.violaceum), Microsporum canis, Epidermophyton floccosum. плесневые грибы (напр. Aspergillus, Cladosporium. Scopulariopsis brevicalius), дрожжевые грибы, главным образом Candida albicans, и некоторые диморфные грибы. На грибы Candida и его мицелиальные формы оказывает в зависимости от вида гриба фунгицидное или фунгистатическое действие.\u003Cbr\u003EТербинафин нарушает ранний этап биосинтеза основного компонента клеточной мембраны гриба эргостерола путём ингибирования фермента сквален-эпоксидазы. Сквален-эпоксидаза не связана с системой цитохрома Р450 (СУР450), поэтому тербинафин не влияет на метаболизм гормонов и лекарственных препаратов, метаболизм которых связан с СУР450.\u003Cbr\u003EПри пероральном применении накапливается в коже, ногтях и в волосах в количестве, оказывающим фунгицидное действие.\u003Cbr\u003EСистемное лечение разноцветного лишая, вызванного Malassezia furfur, неэффективно."},{"name":"Фармакологическая группа","value":"противогрибковые средства"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 2 лет"},{"name":"Условия хранения","value":"В сухом защищенном от света месте при температуре до 25 °С. В недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: тошнота, рвота, боли в нижней части живота, в эпигастральной области.\u003Cbr\u003EЛечение: промывание желудка с последующим назначением активированного угля и/или симптоматическая терапия."},{"name":"Применение при беременности и кормлении грудью","value":"Противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Тербинафин не влияет на способность управлять автомобилем и выполнять работы, требующие повышенной концентрации внимания."},{"name":"Особые указания","value":"Нерегулярное применение тербинафина или преждевременное прекращение лечения приводит к рецидиву заболевания.\u003Cbr\u003EНа длительность терапии могут влиять и такие факторы, как напр. наличие сопутствующих заболеваний, состояние ногтей в начале курса лечения.\u003Cbr\u003EЕсли через 2 недель лечения кожной инфекции не отмечается улучшения состояния, необходимо повторно определить возбудителя заболевания и его чувствительность к препарату.\u003Cbr\u003EСистемное применение при онихомикозе оправдано только в случае тотального поражения большинства ногтей, наличия выраженного подногтевого гиперкератоза, неэффективности предшествующей местной терапии. При лечении онихомикоза клинический ответ, обычно, наблюдается через несколько месяцев после микологического излечения и прекращения курса лечения, что обусловлено скоростью отрастания здорового ногтя. Удаления ногтевых пластинок при лечении онихомикоза кистей в течение 3 нед. и онихомикоза стоп в течение 6 нед не требуется.\u003Cbr\u003EПри наличии тяжёлой почечной недостаточности (клиренс креатинина менее 50 мл/мин или креатинин в крови более 300 мкмоль/л), при нарушении функции печени дозу тербинафина следует уменьшить вдвое.\u003Cbr\u003EПри наличии заболевания печени клиренс тербинафина может быть сниженным.\u003Cbr\u003EПри сниженной функции печени назначают половину взрослой дозой. Во время лечения необходимо контролировать уровень трансаминаз печени в сыворотке крови. В редких случаях через 3 месяца лечения возникает холестаз и гепатит. При появлении признаков нарушения функции печени (слабость, персистирующая тошнота, потеря аппетита, боли в животе, желтуха, потемнение мочи или бесцветный стул) препарат следует отменить.\u003Cbr\u003EНазначение тербинафина больным псориазом требует повышенной осмотрительности, т.к. в очень редких случаях тербинафин может спровоцировать вспышку псориаза.\u003Cbr\u003EПри лечении тербинафином следует соблюдать общие правила гигиены для предотвращения возможности повторного инфицирования через белье и обувь. В процессе лечения (каждые 2 нед.) и в конце его необходимо производить противогрибковую обработку обуви, носков и чулок.\u003Cbr\u003EС осторожностью: печеночная и/или почечная недостаточность; алкоголизм: заболевания крови: опухоли; болезни обмена веществ; патология сосудов конечностей, псориаз."},{"name":"Взаимодействие","value":"Практически не влияет на клиренс препаратов, метаболизирующихся с участием цитохрома Р450 (наир, циклоспорин, терфенадин. толбутамид, триазолам, пероральные контрацептивы).\u003Cbr\u003EИнгибирует изоэнзим СУР206 и препятствует метаболизму таких препаратов, как трициклические антидепрессанты и селективные блокаторы захват а серо гонима (наир, дезипрамин, флувоксамин), (β1-блокаторы (метопролол, пропранолол). противоаритмические средства (флекаинид, пропафенон). МАО-В-ингибиторы (напр. селегилин) и антипсихотические (напр. хлорпромазин, галоперидол).\u003Cbr\u003EЛекарственные препараты-индукторы ферментов СУР450 (напр. рифампицин) могут у скорять выведение тербинафина из организма.\u003Cbr\u003EЛекарственные препараты-ингибиторы СУР450 (напр. циметидин) могут замедлить метаболизм и выведение тербинафина из организма. При одновременном применении этих препаратов может потребоваться коррекция дозы тербинафина. Возможно нарушение менструального цикла при одновременном приёме тербинафина и пероральных контрацептивов.\u003Cbr\u003EСнижает клиренс кофеина на 21 % и продлевает время его полураспада на 31%.\u003Cbr\u003EНе влияет на клиренс антипирина, дигоксина, варфарина.\u003Cbr\u003EЭтанол и другие гепатотоксичные препараты повышают риск развития гепатотоксического эффекта."},{"name":"Регистрационный номер","value":"П N011536/01"},{"name":"Дата государственной регистрации","value":"23.01.2017"},{"name":"Владелец регистрационного удостоверения","value":"Dr. Reddy's Laboratories","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["34324371:35649313","7893318:16077120"]}}},{"name":"Изготовитель","value":"Dr. Reddy's"},{"name":"Фасовщик","value":"Dr. Reddy's"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Экзифин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["17796364:18048656"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"3476425530867931471":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кожа"},{"name":"Назначение","value":"дерматофития гладкой кожи тела, кандидоз, микоз волосистой части головы, микоз кожи, микроспория, онихомикозы, трихофития"},{"name":"Показания к применению","value":"- Микозы волосистой части головы (трихофития, микроспория).\u003Cbr\u003E- Микозы кожи и ногтей, обусловленные Trx chophvton (Т. rubrum. mentagrophytes. verrucosum, violaceum). Microsporum (M. canis, M. gypseum) u Epidennophytom floccosum.\u003Cbr\u003E- Онихомикозы.\u003Cbr\u003E- Тяжёлые. распространённые дерматомикозы гладкой кожи туловища и конечностей, требующие системного лечения.\u003Cbr\u003E- Кандидозы кожи и слизистых оболочек."},{"name":"Противопоказания","value":"Повышенная чувствительность к какому-либо компоненту препарата: детский возраст до 2 лет, т.к. нет достаточного количества данных о применении препарат детьми с массой тела менее 12 кг, беременность, период кормления грудью."},{"name":"Состав","value":"Каждая таблетка содержит:\u003Cbr\u003EАктивное вещество: тербинафина гидрохлорид 281,31 мг (в пересчете на 250 мг тербинафина).\u003Cbr\u003EВспомогательные вещества: целлюлоза микрокристаллическая, натрия гликолат крахмальный, крахмал прежелатинизированный, магния стеарат, кремний коллоидный безводный."},{"name":"Действующее вещество","value":"Тербинафин"},{"name":"Способ применения и дозы","value":"Длительность курса лечения и режим дозирования устанавливается в индивидуальном порядке и зависит от локализации процесса и тяжести заболевания.\u003Cbr\u003EВзрослым:\u003Cbr\u003EОбычная доза: 250 мг (1 таблетка) 1 раз в день.\u003Cbr\u003EОнихомикозы: Продолжительность терапии около 6-12 недель, При поражении ногтей пальцев кистей и стоп (за исключением большого пальца стопы), или при молодом возрасте больного длительность лечение может быть менее 12 недель. При инфекции большого пальца стопы 3-месячный курс лечения обычно достаточен. В редких случаях, при замедленной скорости роста ногтей, может потребоваться более длительное лечение до 6 и более месяцев.\u003Cbr\u003EГрибковые инфекции кожи: Продолжительность лечения при межпальцевой, подошвенной или по типу \"носков\" локализации инфекции составляет 2-6 нед.. при микозах других участков тела: голеней - 2-4 нед.. туловища - 4 нед.: при микозах, вызванных Candida. 2-4 нед.;\u003Cbr\u003Eпри микозах головы, вызванных Microsporum canis - более 4 нед.\u003Cbr\u003EДетям: обычно назначают 125 мг (1/2 таблетки). Продолжительность лечения микозов волосистой части головы около 4-х недель, при заражении Microsporum canis - может быть более длительной.\u003Cbr\u003EПри массе тела менее 20 кг - 62.5 мг (1/4 таблетки) 1 раз в сутки.\u003Cbr\u003EПри массе тела 20 до 40 кг - 125 мг (1/2 таблетки) 1 раз в сутки.\u003Cbr\u003EПри массе более 40 кг - 250 мг (1 таблетка)! раз в сутки.\u003Cbr\u003EПожилым больным препарат назначают в тех же дозах, что и взрослым.\u003Cbr\u003EПри выраженных нарушениях функции печени и/или ночек (клиренс креатинина \u003C 50 мл/мин либо концентрация креатинина в крови более 300 мкмоль/л): 125 мг 1 раз в день."},{"name":"Побочные действия","value":"Побочные действия обычно средней и лёгкой степени тяжести и носят временный характер. Часто встречающиеся побочные действия со стороны органов системы пищеварения: чувство переполненного желудка, диспепсия, тошнота, потеря аппетита, боли в животе, диарея, не часто - нарушение вкусовою восприятия, в г.ч. потеря его, которая восстанавливается через несколько недель после прекращения лечения; редко - холестаз. желтуха, гепатит, бессимптомное увеличение уровня трансаминаз печени. Не смотря на недоказанность причинной связи них нарушений с приёмом тербинафина. в случае развития гепатобилиарной дисфункции лечение Экзифином следует прекратить.\u003Cbr\u003EСо стороны ПНС: редко - парестезия, гипостезия, головокружение, очень редко депрессия, чувство повышенной тревоги.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: часто артралгия. миалгия.\u003Cbr\u003EСо стороны системы кроветворения: очень редко нейтропения, агранулоцитоз, тромбоцитопения.\u003Cbr\u003EСо стороны иммунной системы: часто крапивница, многоформная -эритема, редко системные аллергические реакции (реакции подобные сывороточной болезни, аш модема). очень редко тяжёлые кожные реакции (токсический эпидермальный некролиз. синдром Стивенса-Джонсона. фоточувствительность). При прогрессировании кожных высыпаний течение тербинафином следует прекратить. Прочие: часто головная боль, плохое самочувствие, чувство усталости, очень редко - экзацербация псориаза, усиленное выпадение волос."},{"name":"Фармакологическое действие","value":"Тербинафин относится к группе аллиламинов, обладает широким спектром противогрибкового действия. В низких концентрациях оказывает фунгицидное действие на дерматофиты Trychophyton (Т. rubrum, Т. mentagrophytes, Т. tonsurans, Т. verrucosum, T.violaceum), Microsporum canis, Epidermophyton floccosum. плесневые грибы (напр. Aspergillus, Cladosporium. Scopulariopsis brevicalius), дрожжевые грибы, главным образом Candida albicans, и некоторые диморфные грибы. На грибы Candida и его мицелиальные формы оказывает в зависимости от вида гриба фунгицидное или фунгистатическое действие.\u003Cbr\u003EТербинафин нарушает ранний этап биосинтеза основного компонента клеточной мембраны гриба эргостерола путём ингибирования фермента сквален-эпоксидазы. Сквален-эпоксидаза не связана с системой цитохрома Р450 (СУР450), поэтому тербинафин не влияет на метаболизм гормонов и лекарственных препаратов, метаболизм которых связан с СУР450.\u003Cbr\u003EПри пероральном применении накапливается в коже, ногтях и в волосах в количестве, оказывающим фунгицидное действие.\u003Cbr\u003EСистемное лечение разноцветного лишая, вызванного Malassezia furfur, неэффективно."},{"name":"Фармакологическая группа","value":"противогрибковые средства"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 2 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В сухом защищенном от света месте при температуре до 25 °С. В недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы: тошнота, рвота, боли в нижней части живота, в эпигастральной области.\u003Cbr\u003EЛечение: промывание желудка с последующим назначением активированного угля и/или симптоматическая терапия."},{"name":"Применение при беременности и кормлении грудью","value":"Противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Тербинафин не влияет на способность управлять автомобилем и выполнять работы, требующие повышенной концентрации внимания."},{"name":"Особые указания","value":"Нерегулярное применение тербинафина или преждевременное прекращение лечения приводит к рецидиву заболевания.\u003Cbr\u003EНа длительность терапии могут влиять и такие факторы, как напр. наличие сопутствующих заболеваний, состояние ногтей в начале курса лечения.\u003Cbr\u003EЕсли через 2 недель лечения кожной инфекции не отмечается улучшения состояния, необходимо повторно определить возбудителя заболевания и его чувствительность к препарату.\u003Cbr\u003EСистемное применение при онихомикозе оправдано только в случае тотального поражения большинства ногтей, наличия выраженного подногтевого гиперкератоза, неэффективности предшествующей местной терапии. При лечении онихомикоза клинический ответ, обычно, наблюдается через несколько месяцев после микологического излечения и прекращения курса лечения, что обусловлено скоростью отрастания здорового ногтя. Удаления ногтевых пластинок при лечении онихомикоза кистей в течение 3 нед. и онихомикоза стоп в течение 6 нед не требуется.\u003Cbr\u003EПри наличии тяжёлой почечной недостаточности (клиренс креатинина менее 50 мл/мин или креатинин в крови более 300 мкмоль/л), при нарушении функции печени дозу тербинафина следует уменьшить вдвое.\u003Cbr\u003EПри наличии заболевания печени клиренс тербинафина может быть сниженным.\u003Cbr\u003EПри сниженной функции печени назначают половину взрослой дозой. Во время лечения необходимо контролировать уровень трансаминаз печени в сыворотке крови. В редких случаях через 3 месяца лечения возникает холестаз и гепатит. При появлении признаков нарушения функции печени (слабость, персистирующая тошнота, потеря аппетита, боли в животе, желтуха, потемнение мочи или бесцветный стул) препарат следует отменить.\u003Cbr\u003EНазначение тербинафина больным псориазом требует повышенной осмотрительности, т.к. в очень редких случаях тербинафин может спровоцировать вспышку псориаза.\u003Cbr\u003EПри лечении тербинафином следует соблюдать общие правила гигиены для предотвращения возможности повторного инфицирования через белье и обувь. В процессе лечения (каждые 2 нед.) и в конце его необходимо производить противогрибковую обработку обуви, носков и чулок.\u003Cbr\u003EС осторожностью: печеночная и/или почечная недостаточность; алкоголизм: заболевания крови: опухоли; болезни обмена веществ; патология сосудов конечностей, псориаз."},{"name":"Взаимодействие","value":"Практически не влияет на клиренс препаратов, метаболизирующихся с участием цитохрома Р450 (наир, циклоспорин, терфенадин. толбутамид, триазолам, пероральные контрацептивы).\u003Cbr\u003EИнгибирует изоэнзим СУР206 и препятствует метаболизму таких препаратов, как трициклические антидепрессанты и селективные блокаторы захват а серо гонима (наир, дезипрамин, флувоксамин), (β1-блокаторы (метопролол, пропранолол). противоаритмические средства (флекаинид, пропафенон). МАО-В-ингибиторы (напр. селегилин) и антипсихотические (напр. хлорпромазин, галоперидол).\u003Cbr\u003EЛекарственные препараты-индукторы ферментов СУР450 (напр. рифампицин) могут у скорять выведение тербинафина из организма.\u003Cbr\u003EЛекарственные препараты-ингибиторы СУР450 (напр. циметидин) могут замедлить метаболизм и выведение тербинафина из организма. При одновременном применении этих препаратов может потребоваться коррекция дозы тербинафина. Возможно нарушение менструального цикла при одновременном приёме тербинафина и пероральных контрацептивов.\u003Cbr\u003EСнижает клиренс кофеина на 21 % и продлевает время его полураспада на 31%.\u003Cbr\u003EНе влияет на клиренс антипирина, дигоксина, варфарина.\u003Cbr\u003EЭтанол и другие гепатотоксичные препараты повышают риск развития гепатотоксического эффекта."},{"name":"Регистрационный номер","value":"П N011536/01"},{"name":"Дата государственной регистрации","value":"23.01.2017"},{"name":"Владелец регистрационного удостоверения","value":"Dr. Reddy's Laboratories"},{"name":"Изготовитель","value":"Dr. Reddy's"},{"name":"Фасовщик","value":"Dr. Reddy's"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Экзифин"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_10793714358870419598"}}}}
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Инструкция

Показания к применению

- Микозы волосистой части головы (трихофития, микроспория).
- Микозы кожи и ногтей, обусловленные Trx chophvton (Т. rubrum. mentagrophytes. verrucosum, violaceum). Microsporum (M. canis, M. gypseum) u Epidennophytom floccosum.
- Онихомикозы.
- Тяжёлые. распространённые дерматомикозы гладкой кожи туловища и конечностей, требующие системного лечения.
- Кандидозы кожи и слизистых оболочек.

Противопоказания

Повышенная чувствительность к какому-либо компоненту препарата: детский возраст до 2 лет, т.к. нет достаточного количества данных о применении препарат детьми с массой тела менее 12 кг, беременность, период кормления грудью.

Способ применения и дозы

Длительность курса лечения и режим дозирования устанавливается в индивидуальном порядке и зависит от локализации процесса и тяжести заболевания.
Взрослым:
Обычная доза: 250 мг (1 таблетка) 1 раз в день.
Онихомикозы: Продолжительность терапии около 6-12 недель, При поражении ногтей пальцев кистей и стоп (за исключением большого пальца стопы), или при молодом возрасте больного длительность лечение может быть менее 12 недель. При инфекции большого пальца стопы 3-месячный курс лечения обычно достаточен. В редких случаях, при замедленной скорости роста ногтей, может потребоваться более длительное лечение до 6 и более месяцев.
Грибковые инфекции кожи: Продолжительность лечения при межпальцевой, подошвенной или по типу "носков" локализации инфекции составляет 2-6 нед.. при микозах других участков тела: голеней - 2-4 нед.. туловища - 4 нед.: при микозах, вызванных Candida. 2-4 нед.;
при микозах головы, вызванных Microsporum canis - более 4 нед.
Детям: обычно назначают 125 мг (1/2 таблетки). Продолжительность лечения микозов волосистой части головы около 4-х недель, при заражении Microsporum canis - может быть более длительной.
При массе тела менее 20 кг - 62.5 мг (1/4 таблетки) 1 раз в сутки.
При массе тела 20 до 40 кг - 125 мг (1/2 таблетки) 1 раз в сутки.
При массе более 40 кг - 250 мг (1 таблетка)! раз в сутки.
Пожилым больным препарат назначают в тех же дозах, что и взрослым.
При выраженных нарушениях функции печени и/или ночек (клиренс креатинина < 50 мл/мин либо концентрация креатинина в крови более 300 мкмоль/л): 125 мг 1 раз в день.
Полная инструкция
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Экзифин таб.
Экзифин таб., 250 мг, 16 шт.
5.0
(3)
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1 вопрос
Инструкция

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Скидка: 22%
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Вместо: 849 ₽1 075 ₽
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5.0
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Рекомендуем

  • Таблетница из 14 секций на семь дней Утро-вечер
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    Таблетница на 1 день, контейнер для таблеток и витаминов на 1 день, Immunit

    Цена 138 ₽ вместо 149
  • Таблетница на день мини для капсул контейнер для таблеток белый
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    Таблетница на день мини для капсул контейнер для таблеток белый

    Цена 282 ₽ вместо 750
  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)
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    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)

    Цена 245 ₽ вместо 263
  • Контейнер для хранения/таблетница/кейс для таблеток
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    Контейнер для хранения/таблетница/кейс для таблеток

    Цена 367 ₽ вместо 699
  • Таблетница на день 3 ячейки Oxitab синяя
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    Таблетница на день 3 ячейки Oxitab синяя

    Цена 241 ₽ вместо 520
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    Реклама
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  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 728 ₽ вместо 1 890
  • Таблетница, органайзер на день, неделю, контейнер для таблеток, лекарств и витамин
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    Таблетница, органайзер на день, неделю, контейнер для таблеток, лекарств и витамин

    Цена 139 ₽ вместо 470
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 400 ₽ вместо 637
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