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ЯндексЯндекс
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Описание

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Эуфиллин р-р для в/в введ., 24 мг/мл, 10 мл, 10 шт.

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Коротко о товаре

Артикул Маркета
4453164799
Тип препарата
Назначение
Действующее вещество
Форма выпуска
раствор для инъекций
Инструкция
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Вспомогательное вещество: вода для инъекций до 1 мл."},{"name":"Действующее вещество","value":"Аминофиллин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-astmy","categoryId":"15756897","navnodeId":"72498","glfilters":["27144131:28708218"]}}},{"name":"Способ применения и дозы","value":"Взрослым: Внутривенно вводят медленно (в течение 4-6 минут) по 5-10 мл 24 мг/мл раствора (0,12- 0,24 г), который предварительно разводят в 10-20 мл изотонического раствора натрия хлорида. При появлении сердцебиения, головокружения, тошноты скорость введения замедляют или переходят на капельное введение, для чего 10-20 мл 24 мг/мл раствора (0,24-0,48 г) разводят в 100-150 мл изотонического раствора натрия хлорида; вводят со скоростью 30-50 капель в минуту. Парентерально вводят эуфиллин до 3 раз в сутки, не более 14 дней. Высшие дозы эуфиллина для взрослых : разовая - 0,25 г, суточная - 0,5 г. При неотложных состояниях взрослым вводят внутривенно в дозе 6 мг/кг, разводят в 10- 20 мл 0.9% раствора NaCl, вводят медленно в течение не менее 5 мин. При астматическом статусе показано в/в капельное введение - 720-750 мг.\u003Cbr\u003E\nДетям: при необходимости вводят эуфиллин внутривенно из расчета разовой дозы 2-3 мг/кг предпочтительно капельно. В возрасте до 3 мес - 30-60 мг/сут, 4-12 мес - 60-90 мг/сут, 2-3 лет - 90-120 мг, 4-7 лет -120- 240 мг, 8-18 лет - 250-500 мг/сут. Высшие дозы для детей внутривенно: разовая - 3 мг/кг, суточная с 2 до 3 лет - 0,09-0,12 г, от 4 до 7 лет - 0,12-0,24 г, от 8 до 18 лет - 0,25-0,5 г. Продолжительность парентерального введения - не более 14 дней. При апноэ новорожденных начальная доза (состояние, характеризующееся периодами отсутствия дыхания в течение 15 с и сопровождающееся цианозом и брадикардией) - 5 мг/кг (по назогастральному зонду), поддерживающая доза - 2 мг/кг в 2 приема. Длительность лечения - несколько недель, в редких случаях - месяцев. Можно назначать ректально в виде микроклизм. Доза для взрослых - 0.24-0.48 г в 20-25 мл теплой воды; детям - меньше, в соответствии с возрастом. Высшие дозы для взрослых ректально - разовая 0.5 г, суточная 1.5 г; в/в - разовая 0.25 г, суточная 0.5 г. Высшие дозы для детей ректально - разовая 7 мг/кг, суточная 15 мг/кг; в/в - разовая 3 мг/кг."},{"name":"Побочные действия","value":"Со стороны нервной системы: головокружение, головная боль, бессонница, возбуждение, тревожность, раздражительность, тремор.\u003Cbr\u003E\nСо стороны сердечно-сосудистой системы: сердцебиение, тахикардия (в т.ч. у плода при приеме беременной в III триместре), аритмии, снижение артериального давления, кардиалгия, увеличение частоты приступов стенокардии.\u003Cbr\u003E\nСо стороны пищеварительной системы: тошнота, рвота, гастроэзофагеальный рефлюкс, изжога, обострение язвенной болезни, диарея, при длительном приеме - снижение аппетита.\u003Cbr\u003E\nАллергические реакции: кожная сыпь, зуд кожи, лихорадка.\u003Cbr\u003E\nПрочие: боль в груди, тахипноэ, ощущение приливов к лицу, альбуминурия, гематурия, гипогликемия, усиление диуреза, повышенное потоотделение.\u003Cbr\u003E\nПобочные эффекты уменьшаются при снижении дозы препарата.\u003Cbr\u003E\nМестные реакции: уплотнение, гиперемия, болезненность в месте введения.\u003Cbr\u003E\nПри ректальном введении - проктит, раздражение слизистой оболочки прямой кишки."},{"name":"Фармакологическое действие","value":"Бронхолитическое средство, производное, пурина; ингибирует фосфодиэстеразу, увеличивает накопление в тканях цАМФ, блокирует аденозиновые (пуриновые) рецепторы; снижает поступление Са2+ через каналы клеточных мембран, уменьшает сократительную активность гладкой мускулатуры. Расслабляет мускулатуру бронхов, увеличивает мукоцилиарный клиренс, стимулирует со-кращение диафрагмы, улучшает функцию дыхательных и межреберных мышц, стимулирует дыхательный центр, повышает его чувствительность к углекислому газу и улучшает альвеолярную вентиляцию, что в конечном итоге приводит к снижению тяжести и частоты эпизодов апноэ. Нормализуя дыхательную функцию, способствует насыщению крови кислородом и снижению концентрации углекислоты. Усиливает вентиляцию легких в условиях гипокалиемии.\u003Cbr\u003E\nОказывает стимулирующее влияние на деятельность сердца, увеличивает силу и частоту сердечных сокращений, повышает коронарный кровоток и потребность миокарда в кислороде. Снижает тонус кровеносных сосудов (главным образом сосудов мозга, кожи и почек). Оказывает периферическое венодилатирующее действие, уменьшает легочное сосудистое сопротивление, понижает давление в \"малом\" круге кровообращения. Увеличивает почечный кровоток, оказывает умеренный диуретический эффект. Расширяет внепеченочные желчные пути. Стабилизирует мембраны тучных клеток, тормозит высвобождение медиаторов аллергических реакций. Тормозит агрегацию тромбоцитов (подавляет фактор активации тромбоцитов и PgE2 альфа), повышает устойчивость эритроцитов к деформации (улучшает реологические свойства крови), уменьшает тромбообразование и нормализует микроциркуляцию. Обладает токолитическим действием, повышает кислотность желудочного сока. При использовании в больших дозах обладает эпилептогенным действием.\u003Cbr\u003E\nБиодоступность- 90-100%. Время достижения максимальной концентрации в плазме крови при внутривенном введении 0.3 г -15 мин, максимальная концентрация в плазме крови - 7 мкг/мл. Объем распределения находится в диапазоне 0.3-0.7 л/кг (30-70% от \"идеальной\" массы тела), в среднем 0.45 л/кг. Связь с белками плазмы у взрослых - 60%, у новорожденных - 36%, у больных циррозом печени - 36%. Проникает в грудное молоко (10% от принятой дозы), через плацентарный барьер (концентрация в сыворотке крови плода несколько выше, чем в сыворотке матери). Бронходилатирующие свойства аминофиллин проявляет в концентрациях 10-20 мкг/мл. Концентрация свыше 20 мг/мл является токсической. Возбуждающий эффект на дыхательный центр реализуется при более низком содержании препарата в крови - 5-10 мкг/мл. Метаболизируется при физиологических значениях pH с высвобождением свободного теофиллина, который далее подвергается метаболизму в печени при участии нескольких изоферментов цитохрома Р450. В результате образуются 1,3-диметилмочевая кислота (45- 55%), которая обладает фармакологической активностью, но уступает теофиллину в 1-5 раз. Кофеин является активным метаболитом и образуется в небольших количествах, за исключением недоношенных новорожденных и детей младше 6 мес, у которых вследствие чрезвычайно длительного Т1/2 кофеина возникает его существенное накопление в организме (до 30% от такового для аминофиллина)\u003Cbr\u003E\nУ детей старше 3 лет и у взрослых феномен кумуляции кофеина отсутствует. Период полувыведения у новорожденных и детей до 6 мес - более 24 ч; у детей старше 6 мес - 3.7 ч; у взрослых - 8.7 ч; у \"курильщиков\" (20-40 сигарет в сутки) - 4-5 ч (после отказа от курения нормализация фармакокинетики через 3-4 мес); у взрослых с хроническими обструктивными заболеваниями легких, \"легочным\" сердцем и легочно-сердечной недостаточностью - свыше 24 ч. Выводится почками. У новорожденных около 50% теофиллина выводится с мочой в неизмененном виде против 10% у взрослых, что связано с недостаточной активностью ферментов печени."},{"name":"Фармакологическая группа","value":"бронходилатирующее средство"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-astmy","categoryId":"15756897","navnodeId":"72498","glfilters":["35947170:36763748"]}}},{"name":"Условия хранения","value":"Хранить в защищенном от света месте при температуре от 15 до 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":": Симптомы: при передозировке наблюдается анорексия, диарея, тошнота, рвота, боли в эпигастральной области, желудочно-кишечное кровотечение, тахикардия, желудочковые аритмии, тремор, генерализованные судороги, гипервентиляция, резкое понижение артериального давления. Лечение передозировки зависит от клинической картины, включает отмену препарата, стимуляцию выведения его из организма (форсированный диурез, гемосорбция, плазмосорбция, гемодиализ, перитонеальный диализ) и назначение симптоматических средств. Для купирования судорог применяется диазепам (в инъекциях). Нельзя применять барбитураты. При выраженной интоксикации (содержание эуфиллина более 50 г/л) рекомендован гемодиализ."},{"name":"Применение при беременности и кормлении грудью","value":"При необходимости назначения препарата в периоды беременности и лактации следует сопоставить предполагаемую пользу для матери и потенциальный риск для плода или новорожденного."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Сведения отсутствуют."},{"name":"Особые указания","value":"Препарат следует применять с осторожностью при следующих состояниях/заболеваниях: тяжелая коронарная недостаточность (острая фаза инфаркта миокарда, стенокардия), распространенный атеросклероз сосудов, гипертрофическая обструктивная кардиомиопатия, частая желудочковая экстрасистолия, повышенная судорожная готовность, печеночная и/или почечная недостаточность, язвенная болезнь желудка и 12-перстной кишки (в анамнезе), кровотечение из желудочно-кишечного тракта в недавнем анамнезе, неконтролируемый гипотиреоз (возможность кумуляции) или тиреотоксикоз, длительная гипертермия, гастроэзофагеальный рефлюкс, гипертрофия предстательной железы, беременность, период лактации, пожилой возраст, детский возраст.\u003Cbr\u003E\nПрепарат назначают с осторожностью пациентам с выраженными нарушениями функции печени и почек, язвенной болезнью желудка и двенадцатиперстной кишки. Пожилым пациентам рекомендуется снизить дозу препарата из-за замедленного выведения из организма. Курящим пациентам рекомендуется увеличить дозу в связи с ускоренным выведением препарата из организма."},{"name":"Взаимодействие","value":"Эфедрин, бета-адреностимуляторы, кофеин и фуросемид усиливают действие препарата. В комбинации с фенобарбиталом, дифенином, рифампицином, изониазидом, карбамазепином или сульфинпиразоном наблюдается снижение эффективности эуфиллина, что может потребовать увеличение применяемых доз препарата. Клиренс препарата снижается при назначении его в комбинации с антибиотиками группы макролидов, линкомицином, аллопуринолом, циметидином, изопреналином, бета-адреноблокаторами, что может потребовать снижения дозы. Пероральные эстрогенсодержащие контрацептивы, противодиарейные препараты, кишечные сорбенты ослабляют, а Н2-гистаминоблокаторы, блокаторы медленных кальциевых каналов, мексилетин усиливают действие (связывают с ферментативной системой цитохрома Р450 и замедляют метаболизм аминофиллина). В случае применения в комбинации с эноксацином и другими фторхинолинами дозу эуфиллина уменьшают. Препарат подавляет терапевтические эффекты карбоната лития и бета-адреноблокаторов. Назначение бета-адреноблокаторов - препятствует бронходилатирующему действию эуфиллина и может вызвать бронхоспазм. Эуфиллин потенцирует действие мочегонных средств за счет увеличения клубочковой фильтрации и уменьшения канальцевой реабсорбции. С осторожностью эуфиллин назначают одновременно с антикоагулянтами, с другими производными теофиллина или пурина. Не рекомендуется применять эуфиллин со средствами, возбуждающими центральную нервную систему (увеличивает нейротоксичность). Препарат нельзя применять с растворами декстрозы, не совмес-тим с растворами глюкозы, фруктозы и левулезы. Следует принимать во внимание pH смешиваемых растворов: фармацевтически несовместим с растворами кислот. Повышает вероятность развития побочных эффектов глюкокортикостероидов, минералокортикостероидов (гипернатриемия), средств для общей анестезии (возрастает риск возникновения желудочковых аритмий). При одновременном применении с эноксацином, небольшими дозами этанола, дисульфирамом, фторхинолонами, рекомбинантным интерфероном альфа, метотрексатом, мексилетином, пропафеноном, тиабендазолом, тиклопидином, верапамилом и при вакцинации против гриппа интенсивность действия аминофиллина может увеличиваться, что может потребовать снижения его дозы."},{"name":"Регистрационный номер","value":"P N002436/01"},{"name":"Дата государственной регистрации","value":"08.07.2019"},{"name":"Владелец регистрационного удостоверения","value":"Новосибхимфарм","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-astmy","categoryId":"15756897","navnodeId":"72498","glfilters":["34324371:35649313","7893318:16001551"]}}},{"name":"Изготовитель","value":"Новосибхимфарм"},{"name":"Фасовщик","value":"Новосибхимфарм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Эуфиллин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-astmy","categoryId":"15756897","navnodeId":"72498","glfilters":["17796364:18053304"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"7132031462339434363":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"дыхательная система"},{"name":"Назначение","value":"апноэ новорожденных, астматический статус, лечение и профилактика нарушений мозгового кровообращения, острая левожелудочковая недостаточность, острые нарушения мозгового кровообращения, отеки почечного происхождения, отечный синдром"},{"name":"Показания к применению","value":"Астматический статус (дополнительная терапия), апноэ новорожденных, нарушение мозгового кровообращения по ишемическому типу (в составе комбинированной терапии), левожелудочковая недостаточность с бронхоспазмом и нарушением дыхания по типу Чейн-Стокса, отечный синдром почечного генеза (в составе комплексной терапии)."},{"name":"Противопоказания","value":"Гиперчувствительность (в т.ч. к другим производным ксантина: кофеин, пентоксифиллин, теобромин), эпилепсия, тяжелая артериальная гипер- или гипотензия, тяжелые тахиаритмии, геморрагический инсульт, кровоизлияние в сетчатку глаза."},{"name":"Состав","value":"Активное вещество: аминофиллин - 24,0 мг или теофиллин - 19,2 мг и этилендиамин - 4,8 мг. Вспомогательное вещество: вода для инъекций до 1 мл."},{"name":"Действующее вещество","value":"Аминофиллин"},{"name":"Способ применения и дозы","value":"Взрослым: Внутривенно вводят медленно (в течение 4-6 минут) по 5-10 мл 24 мг/мл раствора (0,12- 0,24 г), который предварительно разводят в 10-20 мл изотонического раствора натрия хлорида. При появлении сердцебиения, головокружения, тошноты скорость введения замедляют или переходят на капельное введение, для чего 10-20 мл 24 мг/мл раствора (0,24-0,48 г) разводят в 100-150 мл изотонического раствора натрия хлорида; вводят со скоростью 30-50 капель в минуту. Парентерально вводят эуфиллин до 3 раз в сутки, не более 14 дней. Высшие дозы эуфиллина для взрослых : разовая - 0,25 г, суточная - 0,5 г. При неотложных состояниях взрослым вводят внутривенно в дозе 6 мг/кг, разводят в 10- 20 мл 0.9% раствора NaCl, вводят медленно в течение не менее 5 мин. При астматическом статусе показано в/в капельное введение - 720-750 мг.\u003Cbr\u003E\nДетям: при необходимости вводят эуфиллин внутривенно из расчета разовой дозы 2-3 мг/кг предпочтительно капельно. В возрасте до 3 мес - 30-60 мг/сут, 4-12 мес - 60-90 мг/сут, 2-3 лет - 90-120 мг, 4-7 лет -120- 240 мг, 8-18 лет - 250-500 мг/сут. Высшие дозы для детей внутривенно: разовая - 3 мг/кг, суточная с 2 до 3 лет - 0,09-0,12 г, от 4 до 7 лет - 0,12-0,24 г, от 8 до 18 лет - 0,25-0,5 г. Продолжительность парентерального введения - не более 14 дней. При апноэ новорожденных начальная доза (состояние, характеризующееся периодами отсутствия дыхания в течение 15 с и сопровождающееся цианозом и брадикардией) - 5 мг/кг (по назогастральному зонду), поддерживающая доза - 2 мг/кг в 2 приема. Длительность лечения - несколько недель, в редких случаях - месяцев. Можно назначать ректально в виде микроклизм. Доза для взрослых - 0.24-0.48 г в 20-25 мл теплой воды; детям - меньше, в соответствии с возрастом. Высшие дозы для взрослых ректально - разовая 0.5 г, суточная 1.5 г; в/в - разовая 0.25 г, суточная 0.5 г. Высшие дозы для детей ректально - разовая 7 мг/кг, суточная 15 мг/кг; в/в - разовая 3 мг/кг."},{"name":"Побочные действия","value":"Со стороны нервной системы: головокружение, головная боль, бессонница, возбуждение, тревожность, раздражительность, тремор.\u003Cbr\u003E\nСо стороны сердечно-сосудистой системы: сердцебиение, тахикардия (в т.ч. у плода при приеме беременной в III триместре), аритмии, снижение артериального давления, кардиалгия, увеличение частоты приступов стенокардии.\u003Cbr\u003E\nСо стороны пищеварительной системы: тошнота, рвота, гастроэзофагеальный рефлюкс, изжога, обострение язвенной болезни, диарея, при длительном приеме - снижение аппетита.\u003Cbr\u003E\nАллергические реакции: кожная сыпь, зуд кожи, лихорадка.\u003Cbr\u003E\nПрочие: боль в груди, тахипноэ, ощущение приливов к лицу, альбуминурия, гематурия, гипогликемия, усиление диуреза, повышенное потоотделение.\u003Cbr\u003E\nПобочные эффекты уменьшаются при снижении дозы препарата.\u003Cbr\u003E\nМестные реакции: уплотнение, гиперемия, болезненность в месте введения.\u003Cbr\u003E\nПри ректальном введении - проктит, раздражение слизистой оболочки прямой кишки."},{"name":"Фармакологическое действие","value":"Бронхолитическое средство, производное, пурина; ингибирует фосфодиэстеразу, увеличивает накопление в тканях цАМФ, блокирует аденозиновые (пуриновые) рецепторы; снижает поступление Са2+ через каналы клеточных мембран, уменьшает сократительную активность гладкой мускулатуры. Расслабляет мускулатуру бронхов, увеличивает мукоцилиарный клиренс, стимулирует со-кращение диафрагмы, улучшает функцию дыхательных и межреберных мышц, стимулирует дыхательный центр, повышает его чувствительность к углекислому газу и улучшает альвеолярную вентиляцию, что в конечном итоге приводит к снижению тяжести и частоты эпизодов апноэ. Нормализуя дыхательную функцию, способствует насыщению крови кислородом и снижению концентрации углекислоты. Усиливает вентиляцию легких в условиях гипокалиемии.\u003Cbr\u003E\nОказывает стимулирующее влияние на деятельность сердца, увеличивает силу и частоту сердечных сокращений, повышает коронарный кровоток и потребность миокарда в кислороде. Снижает тонус кровеносных сосудов (главным образом сосудов мозга, кожи и почек). Оказывает периферическое венодилатирующее действие, уменьшает легочное сосудистое сопротивление, понижает давление в \"малом\" круге кровообращения. Увеличивает почечный кровоток, оказывает умеренный диуретический эффект. Расширяет внепеченочные желчные пути. Стабилизирует мембраны тучных клеток, тормозит высвобождение медиаторов аллергических реакций. Тормозит агрегацию тромбоцитов (подавляет фактор активации тромбоцитов и PgE2 альфа), повышает устойчивость эритроцитов к деформации (улучшает реологические свойства крови), уменьшает тромбообразование и нормализует микроциркуляцию. Обладает токолитическим действием, повышает кислотность желудочного сока. При использовании в больших дозах обладает эпилептогенным действием.\u003Cbr\u003E\nБиодоступность- 90-100%. Время достижения максимальной концентрации в плазме крови при внутривенном введении 0.3 г -15 мин, максимальная концентрация в плазме крови - 7 мкг/мл. Объем распределения находится в диапазоне 0.3-0.7 л/кг (30-70% от \"идеальной\" массы тела), в среднем 0.45 л/кг. Связь с белками плазмы у взрослых - 60%, у новорожденных - 36%, у больных циррозом печени - 36%. Проникает в грудное молоко (10% от принятой дозы), через плацентарный барьер (концентрация в сыворотке крови плода несколько выше, чем в сыворотке матери). Бронходилатирующие свойства аминофиллин проявляет в концентрациях 10-20 мкг/мл. Концентрация свыше 20 мг/мл является токсической. Возбуждающий эффект на дыхательный центр реализуется при более низком содержании препарата в крови - 5-10 мкг/мл. Метаболизируется при физиологических значениях pH с высвобождением свободного теофиллина, который далее подвергается метаболизму в печени при участии нескольких изоферментов цитохрома Р450. В результате образуются 1,3-диметилмочевая кислота (45- 55%), которая обладает фармакологической активностью, но уступает теофиллину в 1-5 раз. Кофеин является активным метаболитом и образуется в небольших количествах, за исключением недоношенных новорожденных и детей младше 6 мес, у которых вследствие чрезвычайно длительного Т1/2 кофеина возникает его существенное накопление в организме (до 30% от такового для аминофиллина)\u003Cbr\u003E\nУ детей старше 3 лет и у взрослых феномен кумуляции кофеина отсутствует. Период полувыведения у новорожденных и детей до 6 мес - более 24 ч; у детей старше 6 мес - 3.7 ч; у взрослых - 8.7 ч; у \"курильщиков\" (20-40 сигарет в сутки) - 4-5 ч (после отказа от курения нормализация фармакокинетики через 3-4 мес); у взрослых с хроническими обструктивными заболеваниями легких, \"легочным\" сердцем и легочно-сердечной недостаточностью - свыше 24 ч. Выводится почками. У новорожденных около 50% теофиллина выводится с мочой в неизмененном виде против 10% у взрослых, что связано с недостаточной активностью ферментов печени."},{"name":"Фармакологическая группа","value":"бронходилатирующее средство"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить в защищенном от света месте при температуре от 15 до 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":": Симптомы: при передозировке наблюдается анорексия, диарея, тошнота, рвота, боли в эпигастральной области, желудочно-кишечное кровотечение, тахикардия, желудочковые аритмии, тремор, генерализованные судороги, гипервентиляция, резкое понижение артериального давления. Лечение передозировки зависит от клинической картины, включает отмену препарата, стимуляцию выведения его из организма (форсированный диурез, гемосорбция, плазмосорбция, гемодиализ, перитонеальный диализ) и назначение симптоматических средств. Для купирования судорог применяется диазепам (в инъекциях). Нельзя применять барбитураты. При выраженной интоксикации (содержание эуфиллина более 50 г/л) рекомендован гемодиализ."},{"name":"Применение при беременности и кормлении грудью","value":"При необходимости назначения препарата в периоды беременности и лактации следует сопоставить предполагаемую пользу для матери и потенциальный риск для плода или новорожденного."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Сведения отсутствуют."},{"name":"Особые указания","value":"Препарат следует применять с осторожностью при следующих состояниях/заболеваниях: тяжелая коронарная недостаточность (острая фаза инфаркта миокарда, стенокардия), распространенный атеросклероз сосудов, гипертрофическая обструктивная кардиомиопатия, частая желудочковая экстрасистолия, повышенная судорожная готовность, печеночная и/или почечная недостаточность, язвенная болезнь желудка и 12-перстной кишки (в анамнезе), кровотечение из желудочно-кишечного тракта в недавнем анамнезе, неконтролируемый гипотиреоз (возможность кумуляции) или тиреотоксикоз, длительная гипертермия, гастроэзофагеальный рефлюкс, гипертрофия предстательной железы, беременность, период лактации, пожилой возраст, детский возраст.\u003Cbr\u003E\nПрепарат назначают с осторожностью пациентам с выраженными нарушениями функции печени и почек, язвенной болезнью желудка и двенадцатиперстной кишки. Пожилым пациентам рекомендуется снизить дозу препарата из-за замедленного выведения из организма. Курящим пациентам рекомендуется увеличить дозу в связи с ускоренным выведением препарата из организма."},{"name":"Взаимодействие","value":"Эфедрин, бета-адреностимуляторы, кофеин и фуросемид усиливают действие препарата. В комбинации с фенобарбиталом, дифенином, рифампицином, изониазидом, карбамазепином или сульфинпиразоном наблюдается снижение эффективности эуфиллина, что может потребовать увеличение применяемых доз препарата. Клиренс препарата снижается при назначении его в комбинации с антибиотиками группы макролидов, линкомицином, аллопуринолом, циметидином, изопреналином, бета-адреноблокаторами, что может потребовать снижения дозы. Пероральные эстрогенсодержащие контрацептивы, противодиарейные препараты, кишечные сорбенты ослабляют, а Н2-гистаминоблокаторы, блокаторы медленных кальциевых каналов, мексилетин усиливают действие (связывают с ферментативной системой цитохрома Р450 и замедляют метаболизм аминофиллина). В случае применения в комбинации с эноксацином и другими фторхинолинами дозу эуфиллина уменьшают. Препарат подавляет терапевтические эффекты карбоната лития и бета-адреноблокаторов. Назначение бета-адреноблокаторов - препятствует бронходилатирующему действию эуфиллина и может вызвать бронхоспазм. Эуфиллин потенцирует действие мочегонных средств за счет увеличения клубочковой фильтрации и уменьшения канальцевой реабсорбции. С осторожностью эуфиллин назначают одновременно с антикоагулянтами, с другими производными теофиллина или пурина. Не рекомендуется применять эуфиллин со средствами, возбуждающими центральную нервную систему (увеличивает нейротоксичность). Препарат нельзя применять с растворами декстрозы, не совмес-тим с растворами глюкозы, фруктозы и левулезы. Следует принимать во внимание pH смешиваемых растворов: фармацевтически несовместим с растворами кислот. Повышает вероятность развития побочных эффектов глюкокортикостероидов, минералокортикостероидов (гипернатриемия), средств для общей анестезии (возрастает риск возникновения желудочковых аритмий). При одновременном применении с эноксацином, небольшими дозами этанола, дисульфирамом, фторхинолонами, рекомбинантным интерфероном альфа, метотрексатом, мексилетином, пропафеноном, тиабендазолом, тиклопидином, верапамилом и при вакцинации против гриппа интенсивность действия аминофиллина может увеличиваться, что может потребовать снижения его дозы."},{"name":"Регистрационный номер","value":"P N002436/01"},{"name":"Дата государственной регистрации","value":"08.07.2019"},{"name":"Владелец регистрационного удостоверения","value":"Новосибхимфарм"},{"name":"Изготовитель","value":"Новосибхимфарм"},{"name":"Фасовщик","value":"Новосибхимфарм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Эуфиллин"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_4223282976899906073"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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При неотложных состояниях взрослым вводят внутривенно в дозе 6 мг/кг, разводят в 10- 20 мл 0.9% раствора NaCl, вводят медленно в течение не менее 5 мин. При астматическом статусе показано в/в капельное введение - 720-750 мг.\u003Cbr\u003E\nДетям: при необходимости вводят эуфиллин внутривенно из расчета разовой дозы 2-3 мг/кг предпочтительно капельно. В возрасте до 3 мес - 30-60 мг/сут, 4-12 мес - 60-90 мг/сут, 2-3 лет - 90-120 мг, 4-7 лет -120- 240 мг, 8-18 лет - 250-500 мг/сут. Высшие дозы для детей внутривенно: разовая - 3 мг/кг, суточная с 2 до 3 лет - 0,09-0,12 г, от 4 до 7 лет - 0,12-0,24 г, от 8 до 18 лет - 0,25-0,5 г. Продолжительность парентерального введения - не более 14 дней. При апноэ новорожденных начальная доза (состояние, характеризующееся периодами отсутствия дыхания в течение 15 с и сопровождающееся цианозом и брадикардией) - 5 мг/кг (по назогастральному зонду), поддерживающая доза - 2 мг/кг в 2 приема. Длительность лечения - несколько недель, в редких случаях - месяцев. Можно назначать ректально в виде микроклизм. Доза для взрослых - 0.24-0.48 г в 20-25 мл теплой воды; детям - меньше, в соответствии с возрастом. Высшие дозы для взрослых ректально - разовая 0.5 г, суточная 1.5 г; в/в - разовая 0.25 г, суточная 0.5 г. Высшие дозы для детей ректально - разовая 7 мг/кг, суточная 15 мг/кг; в/в - разовая 3 мг/кг."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Со стороны нервной системы: головокружение, головная боль, бессонница, возбуждение, тревожность, раздражительность, тремор.\u003Cbr\u003E\nСо стороны сердечно-сосудистой системы: сердцебиение, тахикардия (в т.ч. у плода при приеме беременной в III триместре), аритмии, снижение артериального давления, кардиалгия, увеличение частоты приступов стенокардии.\u003Cbr\u003E\nСо стороны пищеварительной системы: тошнота, рвота, гастроэзофагеальный рефлюкс, изжога, обострение язвенной болезни, диарея, при длительном приеме - снижение аппетита.\u003Cbr\u003E\nАллергические реакции: кожная сыпь, зуд кожи, лихорадка.\u003Cbr\u003E\nПрочие: боль в груди, тахипноэ, ощущение приливов к лицу, альбуминурия, гематурия, гипогликемия, усиление диуреза, повышенное потоотделение.\u003Cbr\u003E\nПобочные эффекты уменьшаются при снижении дозы препарата.\u003Cbr\u003E\nМестные реакции: уплотнение, гиперемия, болезненность в месте введения.\u003Cbr\u003E\nПри ректальном введении - проктит, раздражение слизистой оболочки прямой кишки."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Бронхолитическое средство, производное, пурина; ингибирует фосфодиэстеразу, увеличивает накопление в тканях цАМФ, блокирует аденозиновые (пуриновые) рецепторы; снижает поступление Са2+ через каналы клеточных мембран, уменьшает сократительную активность гладкой мускулатуры. Расслабляет мускулатуру бронхов, увеличивает мукоцилиарный клиренс, стимулирует со-кращение диафрагмы, улучшает функцию дыхательных и межреберных мышц, стимулирует дыхательный центр, повышает его чувствительность к углекислому газу и улучшает альвеолярную вентиляцию, что в конечном итоге приводит к снижению тяжести и частоты эпизодов апноэ. Нормализуя дыхательную функцию, способствует насыщению крови кислородом и снижению концентрации углекислоты. Усиливает вентиляцию легких в условиях гипокалиемии.\u003Cbr\u003E\nОказывает стимулирующее влияние на деятельность сердца, увеличивает силу и частоту сердечных сокращений, повышает коронарный кровоток и потребность миокарда в кислороде. Снижает тонус кровеносных сосудов (главным образом сосудов мозга, кожи и почек). Оказывает периферическое венодилатирующее действие, уменьшает легочное сосудистое сопротивление, понижает давление в \"малом\" круге кровообращения. Увеличивает почечный кровоток, оказывает умеренный диуретический эффект. Расширяет внепеченочные желчные пути. Стабилизирует мембраны тучных клеток, тормозит высвобождение медиаторов аллергических реакций. Тормозит агрегацию тромбоцитов (подавляет фактор активации тромбоцитов и PgE2 альфа), повышает устойчивость эритроцитов к деформации (улучшает реологические свойства крови), уменьшает тромбообразование и нормализует микроциркуляцию. Обладает токолитическим действием, повышает кислотность желудочного сока. При использовании в больших дозах обладает эпилептогенным действием.\u003Cbr\u003E\nБиодоступность- 90-100%. Время достижения максимальной концентрации в плазме крови при внутривенном введении 0.3 г -15 мин, максимальная концентрация в плазме крови - 7 мкг/мл. Объем распределения находится в диапазоне 0.3-0.7 л/кг (30-70% от \"идеальной\" массы тела), в среднем 0.45 л/кг. Связь с белками плазмы у взрослых - 60%, у новорожденных - 36%, у больных циррозом печени - 36%. Проникает в грудное молоко (10% от принятой дозы), через плацентарный барьер (концентрация в сыворотке крови плода несколько выше, чем в сыворотке матери). Бронходилатирующие свойства аминофиллин проявляет в концентрациях 10-20 мкг/мл. Концентрация свыше 20 мг/мл является токсической. Возбуждающий эффект на дыхательный центр реализуется при более низком содержании препарата в крови - 5-10 мкг/мл. Метаболизируется при физиологических значениях pH с высвобождением свободного теофиллина, который далее подвергается метаболизму в печени при участии нескольких изоферментов цитохрома Р450. В результате образуются 1,3-диметилмочевая кислота (45- 55%), которая обладает фармакологической активностью, но уступает теофиллину в 1-5 раз. Кофеин является активным метаболитом и образуется в небольших количествах, за исключением недоношенных новорожденных и детей младше 6 мес, у которых вследствие чрезвычайно длительного Т1/2 кофеина возникает его существенное накопление в организме (до 30% от такового для аминофиллина)\u003Cbr\u003E\nУ детей старше 3 лет и у взрослых феномен кумуляции кофеина отсутствует. Период полувыведения у новорожденных и детей до 6 мес - более 24 ч; у детей старше 6 мес - 3.7 ч; у взрослых - 8.7 ч; у \"курильщиков\" (20-40 сигарет в сутки) - 4-5 ч (после отказа от курения нормализация фармакокинетики через 3-4 мес); у взрослых с хроническими обструктивными заболеваниями легких, \"легочным\" сердцем и легочно-сердечной недостаточностью - свыше 24 ч. Выводится почками. У новорожденных около 50% теофиллина выводится с мочой в неизмененном виде против 10% у взрослых, что связано с недостаточной активностью ферментов печени."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"бронходилатирующее средство"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"раствор для инъекций"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"парентеральный"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Хранить в защищенном от света месте при температуре от 15 до 25 °С. Хранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":": Симптомы: при передозировке наблюдается анорексия, диарея, тошнота, рвота, боли в эпигастральной области, желудочно-кишечное кровотечение, тахикардия, желудочковые аритмии, тремор, генерализованные судороги, гипервентиляция, резкое понижение артериального давления. Лечение передозировки зависит от клинической картины, включает отмену препарата, стимуляцию выведения его из организма (форсированный диурез, гемосорбция, плазмосорбция, гемодиализ, перитонеальный диализ) и назначение симптоматических средств. Для купирования судорог применяется диазепам (в инъекциях). Нельзя применять барбитураты. При выраженной интоксикации (содержание эуфиллина более 50 г/л) рекомендован гемодиализ."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"При необходимости назначения препарата в периоды беременности и лактации следует сопоставить предполагаемую пользу для матери и потенциальный риск для плода или новорожденного."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Сведения отсутствуют."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Препарат следует применять с осторожностью при следующих состояниях/заболеваниях: тяжелая коронарная недостаточность (острая фаза инфаркта миокарда, стенокардия), распространенный атеросклероз сосудов, гипертрофическая обструктивная кардиомиопатия, частая желудочковая экстрасистолия, повышенная судорожная готовность, печеночная и/или почечная недостаточность, язвенная болезнь желудка и 12-перстной кишки (в анамнезе), кровотечение из желудочно-кишечного тракта в недавнем анамнезе, неконтролируемый гипотиреоз (возможность кумуляции) или тиреотоксикоз, длительная гипертермия, гастроэзофагеальный рефлюкс, гипертрофия предстательной железы, беременность, период лактации, пожилой возраст, детский возраст.\u003Cbr\u003E\nПрепарат назначают с осторожностью пациентам с выраженными нарушениями функции печени и почек, язвенной болезнью желудка и двенадцатиперстной кишки. Пожилым пациентам рекомендуется снизить дозу препарата из-за замедленного выведения из организма. Курящим пациентам рекомендуется увеличить дозу в связи с ускоренным выведением препарата из организма."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Эфедрин, бета-адреностимуляторы, кофеин и фуросемид усиливают действие препарата. В комбинации с фенобарбиталом, дифенином, рифампицином, изониазидом, карбамазепином или сульфинпиразоном наблюдается снижение эффективности эуфиллина, что может потребовать увеличение применяемых доз препарата. Клиренс препарата снижается при назначении его в комбинации с антибиотиками группы макролидов, линкомицином, аллопуринолом, циметидином, изопреналином, бета-адреноблокаторами, что может потребовать снижения дозы. Пероральные эстрогенсодержащие контрацептивы, противодиарейные препараты, кишечные сорбенты ослабляют, а Н2-гистаминоблокаторы, блокаторы медленных кальциевых каналов, мексилетин усиливают действие (связывают с ферментативной системой цитохрома Р450 и замедляют метаболизм аминофиллина). В случае применения в комбинации с эноксацином и другими фторхинолинами дозу эуфиллина уменьшают. Препарат подавляет терапевтические эффекты карбоната лития и бета-адреноблокаторов. Назначение бета-адреноблокаторов - препятствует бронходилатирующему действию эуфиллина и может вызвать бронхоспазм. Эуфиллин потенцирует действие мочегонных средств за счет увеличения клубочковой фильтрации и уменьшения канальцевой реабсорбции. С осторожностью эуфиллин назначают одновременно с антикоагулянтами, с другими производными теофиллина или пурина. Не рекомендуется применять эуфиллин со средствами, возбуждающими центральную нервную систему (увеличивает нейротоксичность). Препарат нельзя применять с растворами декстрозы, не совмес-тим с растворами глюкозы, фруктозы и левулезы. Следует принимать во внимание pH смешиваемых растворов: фармацевтически несовместим с растворами кислот. Повышает вероятность развития побочных эффектов глюкокортикостероидов, минералокортикостероидов (гипернатриемия), средств для общей анестезии (возрастает риск возникновения желудочковых аритмий). При одновременном применении с эноксацином, небольшими дозами этанола, дисульфирамом, фторхинолонами, рекомбинантным интерфероном альфа, метотрексатом, мексилетином, пропафеноном, тиабендазолом, тиклопидином, верапамилом и при вакцинации против гриппа интенсивность действия аминофиллина может увеличиваться, что может потребовать снижения его дозы."},{"description":"","filters":[{"id":16435314,"name":"Регистрационный номер"}],"isMainProperty":false,"name":"Регистрационный номер","value":"P N002436/01"},{"description":"","filters":[{"id":16435315,"name":"Дата государственной регистрации"}],"isMainProperty":false,"name":"Дата государственной регистрации","value":"08.07.2019"},{"description":"","filters":[{"id":34324371,"name":"Тип препарата"},{"id":7893318,"name":"Производитель"}],"isMainProperty":false,"name":"Владелец регистрационного 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    Цена 77 ₽
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  • Эуфиллин таб., 150 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7qw1ziu2v25/toggleWishlist":{"skuId":"101818666753","productId":460216029,"offerId":"gkRzojWeMlbgqTXy7DwSZw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI3a252wEQgZ72pvsCGI+83gcg4dzBBw==","sign":"Q0zfHdOp7/JjIuiuK3SFq/I4uOrgRYity1OKOXwEZzI="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7qw1ziu2v25/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эуфиллин таб., 150 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 10 оценок
    Цена 40 ₽
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  • Эуфиллин таб., 150 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-974ukjxw1hg/toggleWishlist":{"skuId":"661335040","productId":1436721459,"offerId":"hcm-RtdyHKNNkiA3QrokVQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIs8KKrQUQgNisuwIYs+DQByDh3MEH","sign":"7C0nVt/R1t5jZyPZjv92vzO71RwrioMTG/4yJii6zoU="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-974ukjxw1hg/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эуфиллин таб., 150 мг, 30 шт.

    Цена 29 ₽
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  • Инспиракс р-р д/ин.г. фл., 0.25 мг/мл+0.5 мг/мл, 20 мл
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    Инспиракс р-р д/ин.г. фл., 0.25 мг/мл+0.5 мг/мл, 20 мл

    Рейтинг товара: 4.5 из 5
    на основе 2 оценки
    Цена 295 ₽
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  • Ипратропия бромид аэр. д/инг., 20 мкг/доза
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    Ипратропия бромид аэр. д/инг., 20 мкг/доза

    Цена 271 ₽
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  • Респирафен р-р д/инг., 20 мл
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    Респирафен р-р д/инг., 20 мл

    Рейтинг товара: 4.7 из 5
    на основе 3 оценки
    Цена 293 ₽
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  • Сибри Бризхалер капс. с пор. д/инг. с устр. д/ингаляций (бризхалер), 50 мкг, 30 шт.
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    Сибри Бризхалер капс. с пор. д/инг. с устр. д/ингаляций (бризхалер), 50 мкг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 1 988 ₽
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  • Респисальф капс. с пор. д/инг. (с ингалятором), 50 мкг+250 мкг/доза, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-vsmxpeeznce/toggleWishlist":{"skuId":"101771469826","productId":1734819674,"offerId":"AlyGix51jUKVGSqD0bPq9g","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI2v6cuwYQgsi1kPsCGIaInA4g4dzBBw==","sign":"ADmAEuPKi9Va5lxOAe4a4ayKv9yZJOcMpVJUeycT95M="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-vsmxpeeznce/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Респисальф капс. с пор. д/инг. (с ингалятором), 50 мкг+250 мкг/доза, 60 шт.

    Рейтинг товара: 4.9 из 5
    на основе 16 оценок
    Цена 1 283 ₽
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  • Синглон таб. жев., 5 мг, 28 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0ezt3xfe4uqv/toggleWishlist":{"skuId":"186858092","productId":1436721416,"offerId":"bwu_n3mGGXQa5dgE2FjPZw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIiMKKrQUQ7PSMWRj+1bYIIOHcwQc=","sign":"Gqr/ARxfpEV5IArNKmi02V3CsiGh/e0m3/XqBVmnA+E="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0ezt3xfe4uqv/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Синглон таб. жев., 5 мг, 28 шт.

    Рейтинг товара: 4.4 из 5
    на основе 29 оценок
    Цена 1 229 ₽
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  • Фликсотид аэр. д/инг. дозир., 125 мкг/доза
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    Фликсотид аэр. д/инг. дозир., 125 мкг/доза

    Рейтинг товара: 5 из 5
    на основе 16 оценок
    Цена 1 579 ₽
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  • Монтелукаст-ВЕРТЕКС таб. п/о плен., 10 мг, 15 шт.
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    Монтелукаст-ВЕРТЕКС таб. п/о плен., 10 мг, 15 шт.

    Рейтинг товара: 4.9 из 5
    на основе 13 оценок
    Цена 329 ₽
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Инструкция

Показания к применению

Астматический статус (дополнительная терапия), апноэ новорожденных, нарушение мозгового кровообращения по ишемическому типу (в составе комбинированной терапии), левожелудочковая недостаточность с бронхоспазмом и нарушением дыхания по типу Чейн-Стокса, отечный синдром почечного генеза (в составе комплексной терапии).

Противопоказания

Гиперчувствительность (в т.ч. к другим производным ксантина: кофеин, пентоксифиллин, теобромин), эпилепсия, тяжелая артериальная гипер- или гипотензия, тяжелые тахиаритмии, геморрагический инсульт, кровоизлияние в сетчатку глаза.

Способ применения и дозы

Взрослым: Внутривенно вводят медленно (в течение 4-6 минут) по 5-10 мл 24 мг/мл раствора (0,12- 0,24 г), который предварительно разводят в 10-20 мл изотонического раствора натрия хлорида. При появлении сердцебиения, головокружения, тошноты скорость введения замедляют или переходят на капельное введение, для чего 10-20 мл 24 мг/мл раствора (0,24-0,48 г) разводят в 100-150 мл изотонического раствора натрия хлорида; вводят со скоростью 30-50 капель в минуту. Парентерально вводят эуфиллин до 3 раз в сутки, не более 14 дней. Высшие дозы эуфиллина для взрослых : разовая - 0,25 г, суточная - 0,5 г. При неотложных состояниях взрослым вводят внутривенно в дозе 6 мг/кг, разводят в 10- 20 мл 0.9% раствора NaCl, вводят медленно в течение не менее 5 мин. При астматическом статусе показано в/в капельное введение - 720-750 мг.
Детям: при необходимости вводят эуфиллин внутривенно из расчета разовой дозы 2-3 мг/кг предпочтительно капельно. В возрасте до 3 мес - 30-60 мг/сут, 4-12 мес - 60-90 мг/сут, 2-3 лет - 90-120 мг, 4-7 лет -120- 240 мг, 8-18 лет - 250-500 мг/сут. Высшие дозы для детей внутривенно: разовая - 3 мг/кг, суточная с 2 до 3 лет - 0,09-0,12 г, от 4 до 7 лет - 0,12-0,24 г, от 8 до 18 лет - 0,25-0,5 г. Продолжительность парентерального введения - не более 14 дней. При апноэ новорожденных начальная доза (состояние, характеризующееся периодами отсутствия дыхания в течение 15 с и сопровождающееся цианозом и брадикардией) - 5 мг/кг (по назогастральному зонду), поддерживающая доза - 2 мг/кг в 2 приема. Длительность лечения - несколько недель, в редких случаях - месяцев. Можно назначать ректально в виде микроклизм. Доза для взрослых - 0.24-0.48 г в 20-25 мл теплой воды; детям - меньше, в соответствии с возрастом. Высшие дозы для взрослых ректально - разовая 0.5 г, суточная 1.5 г; в/в - разовая 0.25 г, суточная 0.5 г. Высшие дозы для детей ректально - разовая 7 мг/кг, суточная 15 мг/кг; в/в - разовая 3 мг/кг.
Полная инструкция
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Эуфиллин р-р для в/в введ.
Эуфиллин р-р для в/в введ., 24 мг/мл, 10 мл, 10 шт.
5.0
(3)
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1 вопрос
Инструкция

99 ₽

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Рекомендуем

  • Фенибут таб., 250 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748601_0/content/content/gallery":{"title":"Фенибут таб., 250 мг, 20 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/11722550/img_id3095321630055922099.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/11722550/img_id3095321630055922099.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/11722550/img_id3095321630055922099.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/11722550/img_id3095321630055922099.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/11722550/img_id3095321630055922099.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/11722550/img_id3095321630055922099.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4462738/img_id1059274188124857495.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4462738/img_id1059274188124857495.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4462738/img_id1059274188124857495.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4462738/img_id1059274188124857495.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4462738/img_id1059274188124857495.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4462738/img_id1059274188124857495.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4410238/img_id8565092468410903442.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4410238/img_id8565092468410903442.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4410238/img_id8565092468410903442.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4410238/img_id8565092468410903442.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4410238/img_id8565092468410903442.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4410238/img_id8565092468410903442.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1525355/img_id8053624946511682625.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1525355/img_id8053624946511682625.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1525355/img_id8053624946511682625.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1525355/img_id8053624946511682625.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1525355/img_id8053624946511682625.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1525355/img_id8053624946511682625.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCLmG650FEMTDtn4Ys+DQByDt2cEH","sign":"uxoOMvD1n+2UOtPhv7B1ZN7QFgbiphii8S+AZF913v8="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748601_0/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Фенибут таб., 250 мг, 20 шт.

    Цена 110 ₽
  • Эуфиллин р-р для в/в введ., 24 мг/мл, 5 мл, 10 шт.
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    Эуфиллин р-р для в/в введ., 24 мг/мл, 5 мл, 10 шт.

    Цена 77 ₽
  • Карипазим лиоф. д/приг. р-ра д/нар. прим., 350 ПЕ, 10 мл, 1 шт.
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    Карипазим лиоф. д/приг. р-ра д/нар. прим., 350 ПЕ, 10 мл, 1 шт.

    Цена 122 ₽ вместо 172
  • ЛимфоТранзит концентрат напитка фл., 100 мл
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_3/content/content/toggleWishlist":{"skuId":"663078029","productId":1780857920,"offerId":"ckSDDL6aQuHJvFmQ4F0pSQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMD4ltEGEI2Jl7wCGNW7oQYg19zBBw==","sign":"SsKPFbNUJWTdwuUsqCCK38edCpS1j5r2b8kcqMcq504="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_3/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • Левомеколь мазь д/нар. прим., 40 мг/г+7.5 мг/г, 10 г
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    Левомеколь мазь д/нар. прим., 40 мг/г+7.5 мг/г, 10 г

    Цена 180 ₽ вместо 182
  • Акридерм мазь д/нар. прим., 0.05%, 15 г
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    Акридерм мазь д/нар. прим., 0.05%, 15 г

    Цена 105 ₽ вместо 106
  • Эуфиллин таб., 150 мг, 30 шт.
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    Эуфиллин таб., 150 мг, 30 шт.

    Цена 40 ₽
  • Ревмафлекс капс., 60 шт.
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    Ревмафлекс капс., 60 шт.

    Цена 888 ₽ вместо 987
  • Реклама
    {"widgets":{"@light/AdLabel":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content/adLabel":{"adLabel":{"adLabelText":"Реклама","advertizer":"Общество с ограниченной ответственностью Джонсон & Джонсон, ИНН 7725216105, ID #e-1g-100171-VND-ADV","adLabel":1},"advertisementId":1868061,"allowDebug":false,"borderRadius":5,"indents":6}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content/adLabel":{"name":"@light/AdLabel"}}}
    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  • Эуфиллин таб., 150 мг, 30 шт.
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    Эуфиллин таб., 150 мг, 30 шт.

    Цена 29 ₽
  • Инспиракс р-р д/ин.г. фл., 0.25 мг/мл+0.5 мг/мл, 20 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1781573055_10/content/content/toggleWishlist":{"skuId":"661312008","productId":1781573055,"offerId":"FCdNhPVhkld2hG7taFrpVA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCL/LwtEGEIikq7sCGK/f0Acg4dzBBw==","sign":"e/6516FVKMhXQVIPxI/cXVmyBFYA/58+d2z+S8O2rJg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1781573055_10/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Инспиракс р-р д/ин.г. фл., 0.25 мг/мл+0.5 мг/мл, 20 мл

    Цена 295 ₽
  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
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    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Цена 820 ₽ вместо 1 039
  • Ипратропия бромид аэр. д/инг., 20 мкг/доза
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    Ипратропия бромид аэр. д/инг., 20 мкг/доза

    Цена 271 ₽
  • Респирафен р-р д/инг., 20 мл
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    Респирафен р-р д/инг., 20 мл

    Цена 293 ₽
  • Снуп спрей наз., 90 мкг/доза, 15 мл
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    Снуп спрей наз., 90 мкг/доза, 15 мл

    Цена 141 ₽ вместо 191
  • Сибри Бризхалер капс. с пор. д/инг. с устр. д/ингаляций (бризхалер), 50 мкг, 30 шт.
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    Сибри Бризхалер капс. с пор. д/инг. с устр. д/ингаляций (бризхалер), 50 мкг, 30 шт.

    Цена 1 988 ₽
  • Азелик гель д/нар. прим., 15%, 5 мл, 5 г
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    Азелик гель д/нар. прим., 15%, 5 мл, 5 г

    Цена 395 ₽ вместо 450
  • Респисальф капс. с пор. д/инг. (с ингалятором), 50 мкг+250 мкг/доза, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1734819674_17/content/content/gallery":{"title":"Респисальф капс. с пор. д/инг. (с ингалятором), 50 мкг+250 мкг/доза, 60 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4904293/img_id1596970374164357499.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4904293/img_id1596970374164357499.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4904293/img_id1596970374164357499.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4904293/img_id1596970374164357499.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4904293/img_id1596970374164357499.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4904293/img_id1596970374164357499.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5272727/img_id4096941969637289066.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5272727/img_id4096941969637289066.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5272727/img_id4096941969637289066.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5272727/img_id4096941969637289066.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5272727/img_id4096941969637289066.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5272727/img_id4096941969637289066.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCNr+nLsGEILItZD7AhiGiJwOIOHcwQc=","sign":"L9pa6QKsp51L4Mn+6BLFg8ownIPbEnKqTN1EuT8LP+k="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1734819674_17/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Респисальф капс. с пор. д/инг. (с ингалятором), 50 мкг+250 мкг/доза, 60 шт.

    Цена 1 283 ₽
  • Синглон таб. жев., 5 мг, 28 шт.
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    Синглон таб. жев., 5 мг, 28 шт.

    Цена 1 229 ₽
  • Фликсотид аэр. д/инг. дозир., 125 мкг/доза
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1436721423_19/content/content/gallery":{"title":"Фликсотид аэр. д/инг. дозир., 125 мкг/доза","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/1571888/img_id3952796570009247844.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1571888/img_id3952796570009247844.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1571888/img_id3952796570009247844.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1571888/img_id3952796570009247844.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1571888/img_id3952796570009247844.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1571888/img_id3952796570009247844.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/364668/img_id6939830694588048764.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/364668/img_id6939830694588048764.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/364668/img_id6939830694588048764.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/364668/img_id6939830694588048764.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/364668/img_id6939830694588048764.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/364668/img_id6939830694588048764.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4377400/img_id273862420411057582.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4377400/img_id273862420411057582.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4377400/img_id273862420411057582.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4377400/img_id273862420411057582.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4377400/img_id273862420411057582.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4377400/img_id273862420411057582.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/6256254/img_id6848442370961390052.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/6256254/img_id6848442370961390052.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/6256254/img_id6848442370961390052.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/6256254/img_id6848442370961390052.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/6256254/img_id6848442370961390052.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/6256254/img_id6848442370961390052.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/7388241/img_id8475400702110673174.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/7388241/img_id8475400702110673174.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/7388241/img_id8475400702110673174.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/7388241/img_id8475400702110673174.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/7388241/img_id8475400702110673174.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/7388241/img_id8475400702110673174.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCI/Ciq0FEPLYkFkY2d7WBSDh3MEH","sign":"czGhDIkmdnmIYYZ7OdWe5hncUjGrzf0CDDyeaMco1yE="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1436721423_19/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1436721423_19/content/content/toggleWishlist":{"skuId":"186920050","productId":1436721423,"offerId":"szTchyvsVqe2DeanLgKRWg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ0bTUo5uQxPwhEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCI/Ciq0FEPLYkFkY2d7WBSDh3MEH","sign":"czGhDIkmdnmIYYZ7OdWe5hncUjGrzf0CDDyeaMco1yE="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1436721423_19/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Фликсотид аэр. д/инг. дозир., 125 мкг/доза

    Цена 1 579 ₽
  • Ингалятор компрессорный PRO-110 B. Well/Би Велл
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    Ингалятор компрессорный PRO-110 B. Well/Би Велл

    Цена 2 626 ₽ вместо 2 653
  • Реклама
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  • Силденафил-СЗ таб. п/о плен., 25 мг, 20 шт.
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    Силденафил-СЗ таб. п/о плен., 25 мг, 20 шт.

    Цена 205 ₽ вместо 255
  • Монтелукаст-ВЕРТЕКС таб. п/о плен., 10 мг, 15 шт.
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    Монтелукаст-ВЕРТЕКС таб. п/о плен., 10 мг, 15 шт.

    Цена 329 ₽
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