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Описание

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Фликсоназе спрей наз. дозир., 50 мкг/доза, 60 шт.

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У продавца: 
нет • На Маркете: 4.8
(356)
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Количество штук/доз, шт.: 60

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Коротко о товаре

Артикул Маркета
3761523796
Тип препарата
Назначение
Действующее вещество
Возраст
от 4 лет
Инструкция
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Добавляется в виде водного раствора согласно Европейской Фармакопее.\u003Cbr\u003E2. Прибавляют для достижения pH 6,3-6,5, если pH конечной суспензии выше 6,8"},{"name":"Действующее вещество","value":"Флутиказон","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-allergii","categoryId":"15756502","navnodeId":"72464","glfilters":["27144131:28708349"]}}},{"name":"Способ применения и дозы","value":"Только интраназально.\u003Cbr\u003EДля достижения полного терапевтического эффекта необходимо применять препарат регулярно. Максимальный терапевтический эффект может достигаться после 3-4 дней терапии.\u003Cbr\u003EВзрослые и дети старше 12 лет\u003Cbr\u003E1-я неделя: по 2 впрыскивания в каждую ноздрю 1 раз в день (200 мкг в сутки).\u003Cbr\u003EСо 2-ой недели - до 3-х месяцев: но 1 или 2 впрыскивания в каждую ноздрю 1 раз вдень (100-200 мкг в сутки).\u003Cbr\u003EМаксимальная суточная доза- 200 мкг в сутки (не более 2 впрыскиваний в каждую ноздрю).\u003Cbr\u003EОсобые группы пациентов\u003Cbr\u003EПациенты пожилого возраста Обычная доза для взрослых.\u003Cbr\u003EДети от 4 до 12 лет\u003Cbr\u003EПо 1 впрыскиванию в каждую ноздрю 1 раз в день (100 мкг в сутки). Не следует превышать рекомендованной дозы (100 мкг в сутки). Дети в возрасте от 4 до 12 лет должны использовать препарат в течение максимально короткого периода времени, необходимого для достижения контроля над симптомами заболевания Необходимо обратиться к лечащему врачу, если ребенку необходимо применять препарат в течение периода времени, превышающего 2 месяца в году.\u003Cbr\u003EМаксимальная суточная доза- 100 мкг (не более I впрыскивания в каждую ноздрю).\u003Cbr\u003EВ случае отсутствия эффекта от применения препарата у всех возрастных групп пациентов необходимо проконсультироваться с врачом.\u003Cbr\u003EИнструкция по использованию\u003Cbr\u003EПеред употреблением следует осторожно встряхнуть флакон, взять его, поместив указательный и средний пальцы по обе стороны от наконечника, а большой палец-под донышко.\u003Cbr\u003EПри первом использовании препарата или перерыве в его использовании более I недели следует проверить исправность распылителя: направить наконечник от себя, произвести несколько нажатий, пока из наконечника не появится небольшое облачко. Далее необходимо прочистить нос (высморкаться). Закрыть одну ноздрю и ввести наконечник в другую ноздрю. Наклонить голову немного вперед, продолжая держать флакон вертикально. Затем следует начать делать вдох через нос и, продолжая вдыхать, произвести однократное нажатие пальцами для распыления препарата. Выдохнуть через рот. Повторить процедуру для второго распыления в ту же ноздрю, если необходимо. Далее полностью повторить описанную процедуру, введя наконечник в другую ноздрю. После использования следует промокнуть наконечник чистой салфеткой или носовым платком и закрыть его колпачком.\u003Cbr\u003EРаспылитель следует промывать не менее I раза в неделю. Для этого осторожно снять наконечник и промыть его в теплой воде. Стряхнуть избыток воды и оставить для просушивания в теплом месте. Избегать перегрева. Затем осторожно установить наконечник на прежнее место в верхней части флакона. Надеть защитный колпачок.\u003Cbr\u003EЕсли отверстие наконечника засорилось, наконечник следует снять описанным выше способом и оставить на некоторое время в теплой воде. Затем промыть под струей холодной воды, просушить и снова надеть на флакон. Нельзя прочищать отверстие наконечника булавкой или другими острыми предметами."},{"name":"Побочные действия","value":"Нежелательные реакции, представленные ниже, перечислены в соответствии с поражением органов и систем органов и частотой встречаемости. Частота встречаемости определяется следующим образом: очень части (\u003E 1/10), часто (\u003E 1/100 и \u003C 1/10), нечасто (\u003E 1/1000 и \u003C 1/100), редко (\u003E 1/10000 и \u003C 1/1000), очень редко (\u003C 1/10000, включая отдельные случаи). Очень часто, часто и нечасто возникающие нежелательные реакции в основном установлены на основании данных клинических исследований. Реакции, возникающие редко и очень редко, в основном определены из спонтанных сообщений. При формировании частоты встречаемости нежелательных реакций, фоновые показатели в группе плацебо не принимались во внимание, поскольку они были в целом сопоставимы с группой активного лечения.\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EОчень редко: реакции гиперчувствитсльности, в том числе бронхоспазм, сыпь, отек\u003Cbr\u003Eлица и языка, анафилактические реакции, анафилактоидные реакции. Нарушения со стороны нервной системы\u003Cbr\u003EЧасто: головная боль, ощущение неприятного вкуса и запаха.\u003Cbr\u003EО появлении головной боли, ощущения неприятного вкуса и запаха также сообщалось при использовании других назальных спреев. Нарушения со стороны органа зрения\u003Cbr\u003EОчень редко: глаукома, повышение внутриглазного давления, катаракта.\u003Cbr\u003EНезначительное количество спонтанных сообщений было ассоциировано с длительной терапией препаратом.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003Cbr\u003EОчень часто: носовое кровотечение.\u003Cbr\u003EЧасто: сухость слизистой оболочки в полости носа и глотки,\u003Cbr\u003Eраздражение слизистой оболочки в полости носа и глотки.\u003Cbr\u003EДанные нежелательные реакции, а также носовое кровотечение наблюдались и при использовании других интраназальных препаратов. Очень редко: перфорация носовой перегородки (сообщалось при приеме\u003Cbr\u003Eинтраназальных глюкокортикостероидов).\u003Cbr\u003EПри применении некоторых интраназальных глюкокортикостероидов могут развиваться системные эффекты, особенно при назначении в высоких дозах на длительный период времени (см. также раздел \"Особые указания\")."},{"name":"Фармакологическое действие","value":"Механизм действии\u003Cbr\u003EФяутиказона пропионат- вещество, обладающее сильным противовоспалительным действием. При интраназальном введении нс отмечается сколько-нибудь выраженного системного действия и угнетения гипоталамо-гипофизарно-адреналовой системы. Значимого изменения суточной площади под фармакокинетической кривой сывороточного кортизола нс выявлено после введения флутиказона пропионата в дозе 200 мкг/сут по сравнению с плацебо (соотношение: 1,01, 90% ДИ- доверительный интервал от 0,9 до 1,14).\u003Cbr\u003EФлутиказона пропионат оказывает противовоспалительный эффект за счёт взаимодействия е рецепторами глюкокортикостероидов. Подавляет пролиферацию тучных клеток, эозинофилов, лимфоцитов, макрофагов, нейтрофилов; уменьшает выработку медиаторов воспаления и других биологически активных веществ (гистамина, простагландинов. лейкотриенов, цитокинов) во время ранней и поздней фазы аллергической реакции. Флутиказона пропионат оказывает быстрое противовоспалительное действие на слизистую оболочку носа, а его противоаллергический эффект проявляется уже через 2-4 ч после первого применения. Уменьшает чиханье, зуд в носу, насморк, заложенность носа, неприятные ощущения в области придаточных пазух и ощущение давления вокруг носа и глаз. Кроме того, облегчает глазные симптомы, связанные с аллергическим ринитом. Уменьшение выраженности симптоматики (особенно заложенности носа) сохраняется в течение 24 ч после однократного введения спрея в дозе 200 мкг. Флутиказона пропионат улучшает качество жизни пациентов, включая физическую и социальную активность."},{"name":"Фармакологическая группа","value":"глюкокортикостероид для местного применения"},{"name":"Форма выпуска","value":"спрей"},{"name":"Способ применения/введения","value":"назальный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-allergii","categoryId":"15756502","navnodeId":"72464","glfilters":["35947170:36763737"]}}},{"name":"Минимальный возраст применения","value":"от 4 лет"},{"name":"Продолжительность действия","value":"24 часа"},{"name":"Комплектация","value":"Дозирующее устройство и адаптер."},{"name":"Условия хранения","value":"Хранить при темпера туре не выше 30°С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Нет данных об острой или хронической передозировке флутиказопа пропионата.\u003Cbr\u003EУ здоровых добровольцев интраназальнос введение 2 мг флутиказопа пропионата два раза в сутки на протяжении 7 дней не оказывало влияния на функцию гипоталамо- гипофизарно-адрсналовой системы (дозы в 20 раз выше терапевтической). Применение препарата в дозах, выше рекомендованных, в течение длительного периода времени может привести к временному угнетению функции надпочечников.\u003Cbr\u003EВ случае передозировки следует обратиться к врачу."},{"name":"Применение при беременности и кормлении грудью","value":"Перед применением препарата Фликсоназе во время беременности и в период лактации необходимо проконсультироваться с врачом.\u003Cbr\u003EБеременным и кормящим женщинам препарат Фликсоназе можно назначать только в том случае, когда ожидаемая польза для пациентки превышает любой возможный риск для плода или ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В клинических исследованиях не получено данных о влиянии препарата на способность управлять транспортными средствами и другими механизмами, однако следует учи тывать побочные действия, которые может вызвать препарат."},{"name":"Особые указания","value":"Препарат показан только для ннтраназалыюго применения.\u003Cbr\u003EДля взрослых и детей с 12 лет: назальный спрей Фликсоназе не использовать более 3 месяцев. В случае необходимости применения препарата более 3 месяцев необходима консультация врача\u003Cbr\u003EДля детей от 4-х до 12 лет: назальный спрей Фликсоназе не использовать более 2 месяцев. В случае необходимости применения препарата более 2-х месяцев необходима консультация врача. При длительном применении необходим регулярный контроль функции коры надпочечников.\u003Cbr\u003EИмеются сообщения о проявлении системных эффектов при использовании назальных глюкокортикостероидов, особенно в высоких дозах в течение длительного времени. Эти эффекты гораздо менее вероятны, чем при приеме внутрь. Системные эффекты при применении назальных кортикостероидов могут возникать, в частности, при применении высоких доз в течение продолжительного времени. Вероятность возникновения этих эффектов намного ниже, чем при приеме кортикостероидов внутрь, и они могут различаться у отдельных пациентов и между разными кортикостероидными препаратами. Возможные системные эффекты могут включать синдром Иценко-Кушинга, характерные признаки кушингоида, подавление функции надпочечников, задержку роста у детей и подростков, катаракту, глаукому и реже ряд психологических или поведенческих эффектов, включая психомоторную гиперактивность, нарушения сна, тревожность, депрессию или агрессивность (в особенности у детей).\u003Cbr\u003EУ детей, получающих терапию некоторыми интраназальными глюкокортикостероидами в разрешенных дозах, наблюдалось снижение скорости роста. Рекомендуется регулярно контролировать рост детей, получающих длительное лечение интраназальными глюкокортикостероидами. При замедлении роста следует пересмотреть лечение с целью снижения дозы интраназального глюкокортикостероида, но возможности, до минимальной дозы, обеспечивающей поддержание эффективного контроля над симптомами и обратиться к педиатру.\u003Cbr\u003EОдновременное применение ритонавпра и флутиказона пропионата следует избегать за исключением тех случаев, когда потенциальная польза для пациента превысит возможный риск развития побочных системных эффектов кортикостероидов (см. раздел \"Взаимодействие с другими лекарственными препаратами\").\u003Cbr\u003EПолностью эффект флутиказона пропионата в форме назального спрея может проявиться лишь через 3-4 дня лечения.\u003Cbr\u003EРекомендуется прекратить прием препарата и проконсультироваться с врачом, если улучшение отсутствует в течение 4 дней. Консультация с врачом также необходима, если у Вас появились новые симптомы, такие как выраженная лицевая боль, густые выделения из носа, которые могут свидетельствовать об инфекции и не связаны с аллергией. Инфекции носовой полости или придаточных пазух носа требуют соответствующего лечения, но нс являются противопоказанием к применению назального спрея Фликсоназе.\u003Cbr\u003EУ большинства пациентов назальный спрей флутиказона пропионата устраняет симптомы сезонного аллергического ринита, по в некоторых случаях, при очень высокой концентрации в воздухе аллергенов, может понадобиться дополнительная терапия.\u003Cbr\u003EДля купирования симптомов со стороны глаз на фоне успешной терапии сезонных аллергических ринитов может потребоваться дополнительная терапия.\u003Cbr\u003EДля достижения максимального терапевтического эффекта необходимо придерживаться регулярной схемы применения.\u003Cbr\u003EНеобходимо соблюдать осторожность при переводе пациентов с системной глюкокортикостероидной терапии на лечение назальным спреем флутиказона пропионата, особенно если наблюдается нарушение функции надпочечников на фоне регулярного контроля.\u003Cbr\u003EФликсоназе, спрей назальный водный содержит бензалкония хлорид, который может вызывать бронхоспазм.\u003Cbr\u003EВ случае контакта с больными ветряной оспой, корью и в случае изменений со стороны зрения рекомендуется прекратить лечение и обратиться к врач).\u003Cbr\u003E\u003Cbr\u003EС осторожностью:\u003Cbr\u003EПеред применением препарата следует проконсультироваться с врачом в случае, если Вы принимаете:\u003Cbr\u003E- лекарственные препараты для лечения ВИЧ инфекции, такие как ритонавир;\u003Cbr\u003E\u003Cbr\u003E- глюкокортикостероиды для лечения бронхиальной астмы, аллергии, кожной сыпи;\u003Cbr\u003E- лекарственные препараты для лечения грибковых инфекций, такие как кетоконазол;\u003Cbr\u003E- другие мощные ингибиторы изофермента CYP3A, например, итраконазол.\u003Cbr\u003EТакже, проконсультируйтесь с врачом при наличии глаукомы или катаракты.\u003Cbr\u003EС осторожностью принимать при наличии инфекций носовой полости или придаточных пазух носа. Следует учитывать, что инфекционные заболевания носа требуют соответствующего лечения, но не являются противопоказанием к применению назального спрея Фликсоназе."},{"name":"Взаимодействие","value":"Ритонавир (высокоактивный ингибитор изофермента CYP3A4 ферментной системы цитохрома Р450) способен значительно повышать концентрации флутиказона пропионата в плазме крови, в результате чего резко снижается концентрация кортизола в сыворотке. Применение флутиказона пропионата ингаляционно или ннтраназально и ритонавира приводит к развитию системных глюкокортикоидных эффектов, включая синдром Иценко-Кушиига и угнетение функции коры надпочечников. Поэтому следует избегать одновременного использования флутиказона пропионата и ритонавира, за исключением случаев, когда возможная польза превышает риски возникновения системных эффектов. Одновременное применение флутиказона пропионата для ингаляционного применения п менее мощных ингибиторов изофермента CYP3A, таких как кстоконазол и итраконазол приводит к повышению экспозиции флутиказона пропионата и повышению риска системных побочных эффектов. Рекомендуется соблюдать осторожность и, по возможности, избегать долгосрочного совместного применения этих препаратов. Ингибиторы изофермента CYP3A4 ферментной системы цитохрома Р450 вызывают ничтожно малое (эритромицин) или незначительное (кстоконазол) повышение концентраций флутиказона пропионата в плазме, которые не влекут за собой сколько- нибудь заметного снижения концентраций сывороточного кортизола. Тем не менее, следует соблюдать осторожность при сочетанном применении ингибиторов изофермента CYP3A4 ферментной системы цитохрома Р450 (например, кстоконазол) и флутиказона пропионата ввиду возможного повышения плазменной концентрации последнего."},{"name":"Регистрационный номер","value":"П N015682/01"},{"name":"Дата государственной регистрации","value":"10.12.2019"},{"name":"Владелец регистрационного удостоверения","value":"GlaxoSmithKline","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-allergii","categoryId":"15756502","navnodeId":"72464","glfilters":["34324371:35649313","7893318:11906905"]}}},{"name":"Изготовитель","value":"Glaxo Wellcome"},{"name":"Фасовщик","value":"Glaxo Wellcome"},{"name":"Страна-производитель","value":"Испания"},{"name":"Название препарата","value":"Фликсоназе","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-allergii","categoryId":"15756502","navnodeId":"72464","glfilters":["17796364:17882989"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"8957211875747916319":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"носовая полость"},{"name":"Назначение","value":"аллергический ринит, поллиноз"},{"name":"Показания к применению","value":"Лечение круглогодичного и сезонного аллергического ринита, включая иоллиноз (сенную лихорадку) у взрослых и детей с 4-х лет (устранение симптомов, таких как боль и ощущение давления в области околоносовых пазух, заложенность носа, насморк, чихание, зуд в носу, слезотечение)."},{"name":"Противопоказания","value":"Гиперчувствитсльность к флутиказона пропионату' или любому другому компоненту препарата.\u003Cbr\u003EДетский возраст до 4 лет.\u003Cbr\u003EНедавно перенесенная травма носа или операция в полости носа."},{"name":"Состав","value":"СОСТАВ на 1 дозу:\u003Cbr\u003EКомпонент\u003Cbr\u003EВспомогательные вещества\u003Cbr\u003EФлутиказона пропионат (микронизированный) 0,05 мг\u003Cbr\u003EДекстроза 5,00 мг\u003Cbr\u003EАвицел RC591 (целлюлоза микрокристаллическая, кармеллоза натрия) 1,50 мг\u003Cbr\u003EФенилэтанол 0,25 мг\u003Cbr\u003EБензалкония хлорид1 0,02 мг\u003Cbr\u003EПолисорбат 80 0,005 мг\u003Cbr\u003EХлористоводородная кислота2 до pH 6,3-6,5 мг\u003Cbr\u003EВода очищенная до 100.00 мг\u003Cbr\u003EПримечание:\u003Cbr\u003E1. Добавляется в виде водного раствора согласно Европейской Фармакопее.\u003Cbr\u003E2. Прибавляют для достижения pH 6,3-6,5, если pH конечной суспензии выше 6,8"},{"name":"Действующее вещество","value":"Флутиказон"},{"name":"Способ применения и дозы","value":"Только интраназально.\u003Cbr\u003EДля достижения полного терапевтического эффекта необходимо применять препарат регулярно. Максимальный терапевтический эффект может достигаться после 3-4 дней терапии.\u003Cbr\u003EВзрослые и дети старше 12 лет\u003Cbr\u003E1-я неделя: по 2 впрыскивания в каждую ноздрю 1 раз в день (200 мкг в сутки).\u003Cbr\u003EСо 2-ой недели - до 3-х месяцев: но 1 или 2 впрыскивания в каждую ноздрю 1 раз вдень (100-200 мкг в сутки).\u003Cbr\u003EМаксимальная суточная доза- 200 мкг в сутки (не более 2 впрыскиваний в каждую ноздрю).\u003Cbr\u003EОсобые группы пациентов\u003Cbr\u003EПациенты пожилого возраста Обычная доза для взрослых.\u003Cbr\u003EДети от 4 до 12 лет\u003Cbr\u003EПо 1 впрыскиванию в каждую ноздрю 1 раз в день (100 мкг в сутки). Не следует превышать рекомендованной дозы (100 мкг в сутки). Дети в возрасте от 4 до 12 лет должны использовать препарат в течение максимально короткого периода времени, необходимого для достижения контроля над симптомами заболевания Необходимо обратиться к лечащему врачу, если ребенку необходимо применять препарат в течение периода времени, превышающего 2 месяца в году.\u003Cbr\u003EМаксимальная суточная доза- 100 мкг (не более I впрыскивания в каждую ноздрю).\u003Cbr\u003EВ случае отсутствия эффекта от применения препарата у всех возрастных групп пациентов необходимо проконсультироваться с врачом.\u003Cbr\u003EИнструкция по использованию\u003Cbr\u003EПеред употреблением следует осторожно встряхнуть флакон, взять его, поместив указательный и средний пальцы по обе стороны от наконечника, а большой палец-под донышко.\u003Cbr\u003EПри первом использовании препарата или перерыве в его использовании более I недели следует проверить исправность распылителя: направить наконечник от себя, произвести несколько нажатий, пока из наконечника не появится небольшое облачко. Далее необходимо прочистить нос (высморкаться). Закрыть одну ноздрю и ввести наконечник в другую ноздрю. Наклонить голову немного вперед, продолжая держать флакон вертикально. Затем следует начать делать вдох через нос и, продолжая вдыхать, произвести однократное нажатие пальцами для распыления препарата. Выдохнуть через рот. Повторить процедуру для второго распыления в ту же ноздрю, если необходимо. Далее полностью повторить описанную процедуру, введя наконечник в другую ноздрю. После использования следует промокнуть наконечник чистой салфеткой или носовым платком и закрыть его колпачком.\u003Cbr\u003EРаспылитель следует промывать не менее I раза в неделю. Для этого осторожно снять наконечник и промыть его в теплой воде. Стряхнуть избыток воды и оставить для просушивания в теплом месте. Избегать перегрева. Затем осторожно установить наконечник на прежнее место в верхней части флакона. Надеть защитный колпачок.\u003Cbr\u003EЕсли отверстие наконечника засорилось, наконечник следует снять описанным выше способом и оставить на некоторое время в теплой воде. Затем промыть под струей холодной воды, просушить и снова надеть на флакон. Нельзя прочищать отверстие наконечника булавкой или другими острыми предметами."},{"name":"Побочные действия","value":"Нежелательные реакции, представленные ниже, перечислены в соответствии с поражением органов и систем органов и частотой встречаемости. Частота встречаемости определяется следующим образом: очень части (\u003E 1/10), часто (\u003E 1/100 и \u003C 1/10), нечасто (\u003E 1/1000 и \u003C 1/100), редко (\u003E 1/10000 и \u003C 1/1000), очень редко (\u003C 1/10000, включая отдельные случаи). Очень часто, часто и нечасто возникающие нежелательные реакции в основном установлены на основании данных клинических исследований. Реакции, возникающие редко и очень редко, в основном определены из спонтанных сообщений. При формировании частоты встречаемости нежелательных реакций, фоновые показатели в группе плацебо не принимались во внимание, поскольку они были в целом сопоставимы с группой активного лечения.\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EОчень редко: реакции гиперчувствитсльности, в том числе бронхоспазм, сыпь, отек\u003Cbr\u003Eлица и языка, анафилактические реакции, анафилактоидные реакции. Нарушения со стороны нервной системы\u003Cbr\u003EЧасто: головная боль, ощущение неприятного вкуса и запаха.\u003Cbr\u003EО появлении головной боли, ощущения неприятного вкуса и запаха также сообщалось при использовании других назальных спреев. Нарушения со стороны органа зрения\u003Cbr\u003EОчень редко: глаукома, повышение внутриглазного давления, катаракта.\u003Cbr\u003EНезначительное количество спонтанных сообщений было ассоциировано с длительной терапией препаратом.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003Cbr\u003EОчень часто: носовое кровотечение.\u003Cbr\u003EЧасто: сухость слизистой оболочки в полости носа и глотки,\u003Cbr\u003Eраздражение слизистой оболочки в полости носа и глотки.\u003Cbr\u003EДанные нежелательные реакции, а также носовое кровотечение наблюдались и при использовании других интраназальных препаратов. Очень редко: перфорация носовой перегородки (сообщалось при приеме\u003Cbr\u003Eинтраназальных глюкокортикостероидов).\u003Cbr\u003EПри применении некоторых интраназальных глюкокортикостероидов могут развиваться системные эффекты, особенно при назначении в высоких дозах на длительный период времени (см. также раздел \"Особые указания\")."},{"name":"Фармакологическое действие","value":"Механизм действии\u003Cbr\u003EФяутиказона пропионат- вещество, обладающее сильным противовоспалительным действием. При интраназальном введении нс отмечается сколько-нибудь выраженного системного действия и угнетения гипоталамо-гипофизарно-адреналовой системы. Значимого изменения суточной площади под фармакокинетической кривой сывороточного кортизола нс выявлено после введения флутиказона пропионата в дозе 200 мкг/сут по сравнению с плацебо (соотношение: 1,01, 90% ДИ- доверительный интервал от 0,9 до 1,14).\u003Cbr\u003EФлутиказона пропионат оказывает противовоспалительный эффект за счёт взаимодействия е рецепторами глюкокортикостероидов. Подавляет пролиферацию тучных клеток, эозинофилов, лимфоцитов, макрофагов, нейтрофилов; уменьшает выработку медиаторов воспаления и других биологически активных веществ (гистамина, простагландинов. лейкотриенов, цитокинов) во время ранней и поздней фазы аллергической реакции. Флутиказона пропионат оказывает быстрое противовоспалительное действие на слизистую оболочку носа, а его противоаллергический эффект проявляется уже через 2-4 ч после первого применения. Уменьшает чиханье, зуд в носу, насморк, заложенность носа, неприятные ощущения в области придаточных пазух и ощущение давления вокруг носа и глаз. Кроме того, облегчает глазные симптомы, связанные с аллергическим ринитом. Уменьшение выраженности симптоматики (особенно заложенности носа) сохраняется в течение 24 ч после однократного введения спрея в дозе 200 мкг. Флутиказона пропионат улучшает качество жизни пациентов, включая физическую и социальную активность."},{"name":"Фармакологическая группа","value":"глюкокортикостероид для местного применения"},{"name":"Форма выпуска","value":"спрей"},{"name":"Способ применения/введения","value":"назальный"},{"name":"Минимальный возраст применения","value":"от 4 лет"},{"name":"Продолжительность действия","value":"24 часа"},{"name":"Комплектация","value":"Дозирующее устройство и адаптер."}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при темпера туре не выше 30°С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Нет данных об острой или хронической передозировке флутиказопа пропионата.\u003Cbr\u003EУ здоровых добровольцев интраназальнос введение 2 мг флутиказопа пропионата два раза в сутки на протяжении 7 дней не оказывало влияния на функцию гипоталамо- гипофизарно-адрсналовой системы (дозы в 20 раз выше терапевтической). Применение препарата в дозах, выше рекомендованных, в течение длительного периода времени может привести к временному угнетению функции надпочечников.\u003Cbr\u003EВ случае передозировки следует обратиться к врачу."},{"name":"Применение при беременности и кормлении грудью","value":"Перед применением препарата Фликсоназе во время беременности и в период лактации необходимо проконсультироваться с врачом.\u003Cbr\u003EБеременным и кормящим женщинам препарат Фликсоназе можно назначать только в том случае, когда ожидаемая польза для пациентки превышает любой возможный риск для плода или ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В клинических исследованиях не получено данных о влиянии препарата на способность управлять транспортными средствами и другими механизмами, однако следует учи тывать побочные действия, которые может вызвать препарат."},{"name":"Особые указания","value":"Препарат показан только для ннтраназалыюго применения.\u003Cbr\u003EДля взрослых и детей с 12 лет: назальный спрей Фликсоназе не использовать более 3 месяцев. В случае необходимости применения препарата более 3 месяцев необходима консультация врача\u003Cbr\u003EДля детей от 4-х до 12 лет: назальный спрей Фликсоназе не использовать более 2 месяцев. В случае необходимости применения препарата более 2-х месяцев необходима консультация врача. При длительном применении необходим регулярный контроль функции коры надпочечников.\u003Cbr\u003EИмеются сообщения о проявлении системных эффектов при использовании назальных глюкокортикостероидов, особенно в высоких дозах в течение длительного времени. Эти эффекты гораздо менее вероятны, чем при приеме внутрь. Системные эффекты при применении назальных кортикостероидов могут возникать, в частности, при применении высоких доз в течение продолжительного времени. Вероятность возникновения этих эффектов намного ниже, чем при приеме кортикостероидов внутрь, и они могут различаться у отдельных пациентов и между разными кортикостероидными препаратами. Возможные системные эффекты могут включать синдром Иценко-Кушинга, характерные признаки кушингоида, подавление функции надпочечников, задержку роста у детей и подростков, катаракту, глаукому и реже ряд психологических или поведенческих эффектов, включая психомоторную гиперактивность, нарушения сна, тревожность, депрессию или агрессивность (в особенности у детей).\u003Cbr\u003EУ детей, получающих терапию некоторыми интраназальными глюкокортикостероидами в разрешенных дозах, наблюдалось снижение скорости роста. Рекомендуется регулярно контролировать рост детей, получающих длительное лечение интраназальными глюкокортикостероидами. При замедлении роста следует пересмотреть лечение с целью снижения дозы интраназального глюкокортикостероида, но возможности, до минимальной дозы, обеспечивающей поддержание эффективного контроля над симптомами и обратиться к педиатру.\u003Cbr\u003EОдновременное применение ритонавпра и флутиказона пропионата следует избегать за исключением тех случаев, когда потенциальная польза для пациента превысит возможный риск развития побочных системных эффектов кортикостероидов (см. раздел \"Взаимодействие с другими лекарственными препаратами\").\u003Cbr\u003EПолностью эффект флутиказона пропионата в форме назального спрея может проявиться лишь через 3-4 дня лечения.\u003Cbr\u003EРекомендуется прекратить прием препарата и проконсультироваться с врачом, если улучшение отсутствует в течение 4 дней. Консультация с врачом также необходима, если у Вас появились новые симптомы, такие как выраженная лицевая боль, густые выделения из носа, которые могут свидетельствовать об инфекции и не связаны с аллергией. Инфекции носовой полости или придаточных пазух носа требуют соответствующего лечения, но нс являются противопоказанием к применению назального спрея Фликсоназе.\u003Cbr\u003EУ большинства пациентов назальный спрей флутиказона пропионата устраняет симптомы сезонного аллергического ринита, по в некоторых случаях, при очень высокой концентрации в воздухе аллергенов, может понадобиться дополнительная терапия.\u003Cbr\u003EДля купирования симптомов со стороны глаз на фоне успешной терапии сезонных аллергических ринитов может потребоваться дополнительная терапия.\u003Cbr\u003EДля достижения максимального терапевтического эффекта необходимо придерживаться регулярной схемы применения.\u003Cbr\u003EНеобходимо соблюдать осторожность при переводе пациентов с системной глюкокортикостероидной терапии на лечение назальным спреем флутиказона пропионата, особенно если наблюдается нарушение функции надпочечников на фоне регулярного контроля.\u003Cbr\u003EФликсоназе, спрей назальный водный содержит бензалкония хлорид, который может вызывать бронхоспазм.\u003Cbr\u003EВ случае контакта с больными ветряной оспой, корью и в случае изменений со стороны зрения рекомендуется прекратить лечение и обратиться к врач).\u003Cbr\u003E\u003Cbr\u003EС осторожностью:\u003Cbr\u003EПеред применением препарата следует проконсультироваться с врачом в случае, если Вы принимаете:\u003Cbr\u003E- лекарственные препараты для лечения ВИЧ инфекции, такие как ритонавир;\u003Cbr\u003E\u003Cbr\u003E- глюкокортикостероиды для лечения бронхиальной астмы, аллергии, кожной сыпи;\u003Cbr\u003E- лекарственные препараты для лечения грибковых инфекций, такие как кетоконазол;\u003Cbr\u003E- другие мощные ингибиторы изофермента CYP3A, например, итраконазол.\u003Cbr\u003EТакже, проконсультируйтесь с врачом при наличии глаукомы или катаракты.\u003Cbr\u003EС осторожностью принимать при наличии инфекций носовой полости или придаточных пазух носа. Следует учитывать, что инфекционные заболевания носа требуют соответствующего лечения, но не являются противопоказанием к применению назального спрея Фликсоназе."},{"name":"Взаимодействие","value":"Ритонавир (высокоактивный ингибитор изофермента CYP3A4 ферментной системы цитохрома Р450) способен значительно повышать концентрации флутиказона пропионата в плазме крови, в результате чего резко снижается концентрация кортизола в сыворотке. Применение флутиказона пропионата ингаляционно или ннтраназально и ритонавира приводит к развитию системных глюкокортикоидных эффектов, включая синдром Иценко-Кушиига и угнетение функции коры надпочечников. Поэтому следует избегать одновременного использования флутиказона пропионата и ритонавира, за исключением случаев, когда возможная польза превышает риски возникновения системных эффектов. Одновременное применение флутиказона пропионата для ингаляционного применения п менее мощных ингибиторов изофермента CYP3A, таких как кстоконазол и итраконазол приводит к повышению экспозиции флутиказона пропионата и повышению риска системных побочных эффектов. Рекомендуется соблюдать осторожность и, по возможности, избегать долгосрочного совместного применения этих препаратов. Ингибиторы изофермента CYP3A4 ферментной системы цитохрома Р450 вызывают ничтожно малое (эритромицин) или незначительное (кстоконазол) повышение концентраций флутиказона пропионата в плазме, которые не влекут за собой сколько- нибудь заметного снижения концентраций сывороточного кортизола. Тем не менее, следует соблюдать осторожность при сочетанном применении ингибиторов изофермента CYP3A4 ферментной системы цитохрома Р450 (например, кстоконазол) и флутиказона пропионата ввиду возможного повышения плазменной концентрации последнего."},{"name":"Регистрационный номер","value":"П N015682/01"},{"name":"Дата государственной регистрации","value":"10.12.2019"},{"name":"Владелец регистрационного удостоверения","value":"GlaxoSmithKline"},{"name":"Изготовитель","value":"Glaxo Wellcome"},{"name":"Фасовщик","value":"Glaxo Wellcome"},{"name":"Страна-производитель","value":"Испания"},{"name":"Название препарата","value":"Фликсоназе"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_8785996681638278626"}}}}
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680 ₽

Скидка: 20%
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Вместо:851 ₽
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    • Фринозол спрей наз., 2,5 мг/мл+2,5 мг/мл, 15 мл
      –2 %
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      Фринозол спрей наз., 2,5 мг/мл+2,5 мг/мл, 15 мл

      Рейтинг товара: 4.8 из 5
      на основе 9 оценок
      С картой  Пэй
      Цена с картой Яндекс Пэй 383 ₽ вместо 391
      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    • Момат Рино Адванс спрей наз. дозир., 140 мкг + 50 мкг/доза, 75 шт.
      –1 %
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      Момат Рино Адванс спрей наз. дозир., 140 мкг + 50 мкг/доза, 75 шт.

      Рейтинг товара: 4.8 из 5
      на основе 17 оценок
      С картой  Пэй
      Цена с картой Яндекс Пэй 567 ₽ вместо 573
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Рино Адванс спрей наз. дозир., 140 мкг + 50 мкг/доза, 75 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    • Нозефрин Алерджи спрей назальный дозированный, 50 мкг/доза, 120 шт.
      –16 %
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      Нозефрин Алерджи спрей назальный дозированный, 50 мкг/доза, 120 шт.

      Рейтинг товара: 4.8 из 5
      на основе 55 оценок
      С картой  Пэй
      Цена с картой Яндекс Пэй 470 ₽ вместо 475
      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    • Назарел спрей наз. дозир. фл., 50 мкг/доза
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      Назарел спрей наз. дозир. фл., 50 мкг/доза

      Рейтинг товара: 4.9 из 5
      на основе 16 оценок
      Цена 720 ₽
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    • Назонекс спрей наз. дозир. фл., 50 мкг/доза, 10 г, 60 шт.
      {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-rius2b5yx6b/toggleWishlist":{"skuId":"101627890590","productId":186514884,"offerId":"wPobBOPz4PrzU-V_iMhTCQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQg6uZlKP0wsgWEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIxPv3WBCel/rL+gIY9K2HBCDW2cEH","sign":"RMlyasN1I1/ezTz122iD125VA44usQNoPj6twH9Akoc="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-rius2b5yx6b/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

      Назонекс спрей наз. дозир. фл., 50 мкг/доза, 10 г, 60 шт.

      Рейтинг товара: 4.9 из 5
      на основе 291 оценка
      Цена 608 ₽
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    • Насобек спрей наз. дозир., 50 мкг/доза, 200 шт.
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      Насобек спрей наз. дозир., 50 мкг/доза, 200 шт.

      Рейтинг товара: 4.8 из 5
      на основе 26 оценок
      Цена 194 ₽
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    • Назаваль спрей наз. дозир. фл., 500 мг, 19 г, 200 шт.
      –1 %
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      Назаваль спрей наз. дозир. фл., 500 мг, 19 г, 200 шт.

      Рейтинг товара: 4.8 из 5
      на основе 30 оценок
      С картой  Пэй
      Цена с картой Яндекс Пэй 532 ₽ вместо 537
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    • Авамис спрей наз. дозир. фл., 27,5 мкг/доза
      –16 %
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      Авамис спрей наз. дозир. фл., 27,5 мкг/доза

      Рейтинг товара: 4.8 из 5
      на основе 19 оценок
      Цена 2 092 ₽ вместо 2 489
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    • Азеластин-Ксантис спрей наз. дозир. фл., 140 мкг/доза, 10 мл
      –2 %
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      Азеластин-Ксантис спрей наз. дозир. фл., 140 мкг/доза, 10 мл

      Рейтинг товара: 5 из 5
      на основе 5 оценок
      С картой  Пэй
      Цена с картой Яндекс Пэй 595 ₽ вместо 607
      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    • Назонекс Аллерджи спрей наз. дозир. фл., 50 мкг/доза, 18 г
      –1 %
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      Назонекс Аллерджи спрей наз. дозир. фл., 50 мкг/доза, 18 г

      Рейтинг товара: 4.7 из 5
      на основе 65 оценок
      С картой  Пэй
      Цена с картой Яндекс Пэй 1 030 ₽ вместо 1 040
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    • Дезринит спрей наз. дозир. фл., 50 мкг/доза, 18 г
      –15 %
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      Дезринит спрей наз. дозир. фл., 50 мкг/доза, 18 г

      Рейтинг товара: 4.9 из 5
      на основе 19 оценок
      Цена 862 ₽ вместо 1 017
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    Инструкция

    Показания к применению

    Лечение круглогодичного и сезонного аллергического ринита, включая иоллиноз (сенную лихорадку) у взрослых и детей с 4-х лет (устранение симптомов, таких как боль и ощущение давления в области околоносовых пазух, заложенность носа, насморк, чихание, зуд в носу, слезотечение).

    Противопоказания

    Гиперчувствитсльность к флутиказона пропионату' или любому другому компоненту препарата.
    Детский возраст до 4 лет.
    Недавно перенесенная травма носа или операция в полости носа.

    Способ применения и дозы

    Только интраназально.
    Для достижения полного терапевтического эффекта необходимо применять препарат регулярно. Максимальный терапевтический эффект может достигаться после 3-4 дней терапии.
    Взрослые и дети старше 12 лет
    1-я неделя: по 2 впрыскивания в каждую ноздрю 1 раз в день (200 мкг в сутки).
    Со 2-ой недели - до 3-х месяцев: но 1 или 2 впрыскивания в каждую ноздрю 1 раз вдень (100-200 мкг в сутки).
    Максимальная суточная доза- 200 мкг в сутки (не более 2 впрыскиваний в каждую ноздрю).
    Особые группы пациентов
    Пациенты пожилого возраста Обычная доза для взрослых.
    Дети от 4 до 12 лет
    По 1 впрыскиванию в каждую ноздрю 1 раз в день (100 мкг в сутки). Не следует превышать рекомендованной дозы (100 мкг в сутки). Дети в возрасте от 4 до 12 лет должны использовать препарат в течение максимально короткого периода времени, необходимого для достижения контроля над симптомами заболевания Необходимо обратиться к лечащему врачу, если ребенку необходимо применять препарат в течение периода времени, превышающего 2 месяца в году.
    Максимальная суточная доза- 100 мкг (не более I впрыскивания в каждую ноздрю).
    В случае отсутствия эффекта от применения препарата у всех возрастных групп пациентов необходимо проконсультироваться с врачом.
    Инструкция по использованию
    Перед употреблением следует осторожно встряхнуть флакон, взять его, поместив указательный и средний пальцы по обе стороны от наконечника, а большой палец-под донышко.
    При первом использовании препарата или перерыве в его использовании более I недели следует проверить исправность распылителя: направить наконечник от себя, произвести несколько нажатий, пока из наконечника не появится небольшое облачко. Далее необходимо прочистить нос (высморкаться). Закрыть одну ноздрю и ввести наконечник в другую ноздрю. Наклонить голову немного вперед, продолжая держать флакон вертикально. Затем следует начать делать вдох через нос и, продолжая вдыхать, произвести однократное нажатие пальцами для распыления препарата. Выдохнуть через рот. Повторить процедуру для второго распыления в ту же ноздрю, если необходимо. Далее полностью повторить описанную процедуру, введя наконечник в другую ноздрю. После использования следует промокнуть наконечник чистой салфеткой или носовым платком и закрыть его колпачком.
    Распылитель следует промывать не менее I раза в неделю. Для этого осторожно снять наконечник и промыть его в теплой воде. Стряхнуть избыток воды и оставить для просушивания в теплом месте. Избегать перегрева. Затем осторожно установить наконечник на прежнее место в верхней части флакона. Надеть защитный колпачок.
    Если отверстие наконечника засорилось, наконечник следует снять описанным выше способом и оставить на некоторое время в теплой воде. Затем промыть под струей холодной воды, просушить и снова надеть на флакон. Нельзя прочищать отверстие наконечника булавкой или другими острыми предметами.
    Полная инструкция
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    Фликсоназе спрей наз. дозир.
    Фликсоназе спрей наз. дозир., 50 мкг/доза, 60 шт.
    У продавца: 
    нет • На Маркете: 4.8
    (356)
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    8 вопросов
    Инструкция

    680 ₽

    Скидка: 20%
    –20 %
    Вместо:851 ₽
    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  • Момат Рино спрей наз. дозир., 50 мкг/доза, 60 шт.
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    Момат Рино спрей наз. дозир., 50 мкг/доза, 60 шт.

    Цена 420 ₽ вместо 424
  • Жидкий пластырь Fixplast c пантенолом, 60 мл
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    Жидкий пластырь Fixplast c пантенолом, 60 мл

    Цена 355 ₽ вместо 399
  • Крем для лица и тела после загара MIXIT "BACK TO SUN" защитный, увлажняющий, с пантенолом и алоэ вера, 150 мл
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    Крем для лица и тела после загара MIXIT "BACK TO SUN" защитный, увлажняющий, с пантенолом и алоэ вера, 150 мл

    Цена 543 ₽ вместо 1 110
  • Фринозол спрей наз., 2,5 мг/мл+2,5 мг/мл, 15 мл
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    Фринозол спрей наз., 2,5 мг/мл+2,5 мг/мл, 15 мл

    Цена 347 ₽ вместо 350
  • Нозефрин Алерджи спрей назальный дозированный, 50 мкг/доза, 120 шт.
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    Нозефрин Алерджи спрей назальный дозированный, 50 мкг/доза, 120 шт.

    Цена 470 ₽ вместо 559
  • Назарел спрей наз. дозир. фл., 50 мкг/доза
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    Назарел спрей наз. дозир. фл., 50 мкг/доза

    Цена 720 ₽
  • Назонекс спрей наз. дозир. фл., 50 мкг/доза, 10 г, 60 шт.
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    Назонекс спрей наз. дозир. фл., 50 мкг/доза, 10 г, 60 шт.

    Цена 608 ₽
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 2 025 ₽ вместо 3 500
  • Реклама
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  • ЛимфоТранзит концентрат напитка фл., 100 мл
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • Насобек спрей наз. дозир., 50 мкг/доза, 200 шт.
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    Насобек спрей наз. дозир., 50 мкг/доза, 200 шт.

    Цена 194 ₽
  • Назаваль спрей наз. дозир. фл., 500 мг, 19 г, 200 шт.
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    Назаваль спрей наз. дозир. фл., 500 мг, 19 г, 200 шт.

    Цена 532 ₽ вместо 537
  • Хлоргексидин биглюконат 2% раствор для дезинфекции, антисептик нестерильный с распылителем, 200 мл
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    Хлоргексидин биглюконат 2% раствор для дезинфекции, антисептик нестерильный с распылителем, 200 мл

    Цена 258 ₽ вместо 910
  • Авамис спрей наз. дозир. фл., 27,5 мкг/доза
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    Авамис спрей наз. дозир. фл., 27,5 мкг/доза

    Цена 2 092 ₽ вместо 2 489
  • Назонекс Аллерджи спрей наз. дозир. фл., 50 мкг/доза, 18 г
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    Назонекс Аллерджи спрей наз. дозир. фл., 50 мкг/доза, 18 г

    Цена 1 030 ₽ вместо 1 040
  • Генеролон спрей д/нар. прим., 5%, 60 мл, 1 шт.
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    Генеролон спрей д/нар. прим., 5%, 60 мл, 1 шт.

    Цена 1 149 ₽ вместо 1 161
  • Дезринит спрей наз. дозир. фл., 50 мкг/доза, 18 г
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    Дезринит спрей наз. дозир. фл., 50 мкг/доза, 18 г

    Цена 862 ₽ вместо 1 017
  • Момат Рино Адванс спрей наз. дозир., 140 мкг + 50 мкг/доза, 75 шт.
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    Момат Рино Адванс спрей наз. дозир., 140 мкг + 50 мкг/доза, 75 шт.

    Цена 567 ₽ вместо 573
  • Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.
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    Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.

    Цена 285 ₽ вместо 520
  • Азеластин-Ксантис спрей наз. дозир. фл., 140 мкг/доза, 10 мл
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    Азеластин-Ксантис спрей наз. дозир. фл., 140 мкг/доза, 10 мл

    Цена 546 ₽ вместо 552
  • Дезнэт Средство дезинфицирующее кожный антисептик Дезиптол, 1000 мл, 1000 г, тип крышки: винтовая
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    Дезнэт Средство дезинфицирующее кожный антисептик Дезиптол, 1000 мл, 1000 г, тип крышки: винтовая

    Цена 545 ₽ вместо 650
  • Реклама
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  • IKENA Нафтифин р-р противогрибковый фл., 1%, 37 г, 10 мл, 1 шт., нейтральный, 1 уп.
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    IKENA Нафтифин р-р противогрибковый фл., 1%, 37 г, 10 мл, 1 шт., нейтральный, 1 уп.

    Цена 399 ₽ вместо 480
  • Мизол спрей, 50 мл
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    Мизол спрей, 50 мл

    Цена 734 ₽ вместо 815
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