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Описание

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Фортедетрим капс., 10000 МЕ, 30 шт.

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4.8
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Коротко о товаре

Артикул Маркета
3123190092
Дозировка
Количество штук в упаковке
30 шт.
Тип препарата
Рецептурный препарат
Инструкция
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По сравнению с витамином D2 характеризуется на 25 % более высокой активностью.\u003Cbr\u003EВитамин D связывается со специфическим рецептором витамина D (VDR), который регулирует экспрессию многих генов, включая гены ионного канала TRPV6 (обеспечивает абсорбцию кальция в кишечнике), CALB1 (кальбиндин; обеспечивает транспорт кальция в кровеносное русло), BGLAP (остеокальцин; обеспечивает минерализацию костной ткани и гомеостаз кальция), SPP1 (остеопонтин; регулирует миграцию остеокластов), REN (ренин; обеспечивает регуляцию артериального давления, являясь ключевым элементом ренин-ангиотензин-альдостероновой системы регуляции), IGFBP (связывающий белок инсулинподобного фактора роста; усиливает действие инсулинподобного фактора роста), FGF23 и FGFR23 (фактор роста фибробластов 23; регулируют уровни кальция, фосфат-аниона, процессы клеточного деления фибробластов), TGFB1 (трансформирующий фактор роста бета-1; регулирует процессы клеточного деления и дифференцировки остеоцитов, хондроцитов, фибробластов и кератиноцитов), LRP2 (ЛПНП-рецептор-связанный белок 2; является посредником эндоцитоза липопротеинов низкой плотности), INSR (рецептор инсулина; обеспечивает эффекты инсулина на любые типы клеток).\u003Cbr\u003EВитамин D3 является активным антирахитическим фактором. Самой важной функцией витамина D3 является регулирование метаболизма кальция и фосфатов, что способствует правильной минерализации и росту скелета.\u003Cbr\u003EКолекальциферол играет существенную роль в абсорбции кальция и фосфатов в кишечнике, в транспорте минеральных солей и в процессе кальцификации костей, регулирует также выведение кальция и фосфатов почками.\u003Cbr\u003EКонцентрация ионов кальция в крови обуславливает поддержание тонуса мышц скелетной мускулатуры, функцию миокарда, способствует проведению нервного возбуждения, регулирует процесс свертывания крови.\u003Cbr\u003EНедостаток витамина D в пище, нарушение его всасывания, дефицит кальция, а также недостаточное пребывание на солнце в период быстрого роста ребенка приводит к рахиту, у взрослых - к остеомаляции, у беременных могут возникнуть симптомы тетании, нарушение процессов обызвествления костей новорожденных.\u003Cbr\u003EПовышенная потребность в витамине D возникает у женщин в период менопаузы, поскольку у них часто развивается остеопороз в связи с гормональными нарушениями. Витамин D обладает рядом т. н. внескелетных эффектов.\u003Cbr\u003EВитамин D участвует в функционировании иммунной системы путем модуляции уровней цитокинов и регулирует деление лимфоцитов Т-хелперов и дифференцировку В-лимфоцитов. В ряде исследований отмечено снижение заболеваемости инфекциями дыхательных путей на фоне приема витамина D.\u003Cbr\u003EПоказано, что витамин D является важным звеном гомеостаза иммунной системы: предотвращает аутоиммунные заболевания (сахарный диабет 1 типа, рассеянный склероз, ревматоидный артрит, воспалительные болезни кишечника и др.).\u003Cbr\u003EВитамин D обладает антипролиферативным и продифференцирующим эффектами, которые обуславливают онкопротективное действие витамина D. Отмечено, что частота некоторых опухолей (рак молочной железы, рак толстого кишечника) повышается на фоне низкого уровня витамина D в крови.\u003Cbr\u003EВитамин D участвует в регуляции углеводного и жирового метаболизма путем влияния на синтез IRS1 (субстрат рецептора инсулина 1; участвует во внутриклеточных путях проведения сигнала рецептора инсулина), IGF (инсулинподобный фактор роста; регулирует баланс жировой и мышечной ткани), PPAR-δ (активированный рецептор пролифераторов пероксисом, тип δ; способствует переработке избыточного холестерина).\u003Cbr\u003EПо данным эпидемиологических исследований дефицит витамина D ассоциирован с риском метаболических нарушений (метаболический синдром и сахарный диабет 2 типа). Рецепторы и метаболизирующие ферменты витамина D экспрессируются в артериальных сосудах, сердце и практически всех клетках и тканях, имеющих отношение к патогенезу сердечно-сосудистых заболеваний. На животных моделях показаны антиатеросклеротическое действие, супрессия ренина и предупреждение повреждения миокарда и др. Низкие уровни витамина D у человека связаны с неблагоприятными факторами риска сердечно-сосудистой патологии, такими как сахарный диабет, дислипидемия, артериальная гипертензия, и ассоциированы с риском сердечно-сосудистых катастроф, в т. ч. инсультов. В исследованиях на экспериментальных моделях болезни Альцгеймера показано, что витамин D3 снижал накопление амилоида в мозге и улучшал когнитивную функцию. В неитервенционных исследованиях у человека показано, что частота развития деменции и болезни Альцгеймера увеличивается на фоне низкого уровня витамина D и низкого диетарного потребления витамина D. Отмечалось ухудшение когнитивной функции и заболеваемости болезнью Альцгеймера при низких уровнях витамина D."},{"name":"Состав","value":"Препарат Фортедетрим содержит:\u003Cbr\u003EДействующим веществом является колекальциферол.\u003Cbr\u003EФортедетрим, 2000 МЕ, капсулы\u003Cbr\u003EКаждая капсула содержит 2000 МЕ колекальциферола.\u003Cbr\u003EПрочими ингредиентами (вспомогательными веществами) является сафлоровое масло рафинированное. Капсула: желатин, глицерол, вода очищенная.\u003Cbr\u003EФортедетрим, 4000 МЕ, капсулы\u003Cbr\u003EКаждая капсула содержит 4000 МЕ колекальциферола.\u003Cbr\u003EПрочими ингредиентами (вспомогательными веществами) является сафлоровое масло рафинированное. Капсула: желатин, глицерол, вода очищенная.\u003Cbr\u003EФортедетрим, 10000 МЕ, капсулы\u003Cbr\u003EКаждая капсула содержит 10000 МЕ колекальциферола.\u003Cbr\u003EПрочими ингредиентами (вспомогательными веществами) является сафлоровое масло рафинированное. Капсула: желатин, глицерол, вода очищенная."},{"name":"Взаимодействие","value":"Одновременный прием противосудорожных лекарственных препаратов (таких как фенитоин) или барбитуратов (и, возможно, других лекарственных средств, индуцирующих ферменты печени) может снизить эффективность колекальциферола за счет увеличения скорости биотрансформации колекальциферола в неактивные метаболиты.\u003Cbr\u003EСопутствующая терапия препаратами глюкокортикостероидов может снижать эффективность колекальциферола.\u003Cbr\u003EПероральный прием колекальциферола может усилить терапевтический эффект и токсический потенциал наперстянки и других сердечных гликозидов (риск развития аритмии) за счет развития гиперкальциемии. Требуется тщательное медицинское наблюдение, контроль показателей ЭКГ и уровней кальция в плазме крови и моче, и, при необходимости, корректировка дозы сердечных гликозидов.\u003Cbr\u003EВ случае сопутствующей терапии тиазидными диуретиками, которые уменьшают экскрецию кальция с мочой, рекомендуется контролировать содержание кальция в сыворотке крови и моче.\u003Cbr\u003EОдновременное лечение ионообменными смолами (такими как колестирамин), препаратами орлистата или слабительными средствами (такими как парафиновое масло) может уменьшать всасывание колекальциферола в пищеварительном тракте. Одновременный прием рифампицина и изониазида может снизить эффективность препарата из-за увеличения скорости биотрансформации колекальциферола.\u003Cbr\u003EНа фоне одновременного приема антацидов, содержащих магний, и колекальциферола может повышаться концентрация магния в крови.\u003Cbr\u003EНа фоне одновременного приема антацидов, содержащих алюминий, и колекальциферола может повышаться концентрация алюминия в крови, что увеличивает риск токсического воздействия алюминия."},{"name":"Показания к применению","value":"Лечение и профилактика дефицита и недостаточности витамина D и состояний, вызванных дефицитом витамина D у взрослых."},{"name":"Противопоказания","value":"-повышенная чувствительность к действующему веществу или любому из вспомогательных веществ, перечисленных в разделе \"Состав\";\u003Cbr\u003E-гиперкальциемия и (или) гиперкальциурия;\u003Cbr\u003E-мочекаменная болезнь (образование кальциевых оксалатных камней);\u003Cbr\u003E-гипервитаминоз D;\u003Cbr\u003E-псевдогипопаратиреоз;\u003Cbr\u003E-саркоидоз;\u003Cbr\u003E-активная форма туберкулеза легких;\u003Cbr\u003E-тяжелая почечная недостаточность;\u003Cbr\u003E-беременность и период грудного вскармливания (в данных дозировках);\u003Cbr\u003E-детский возраст до 18 лет."},{"name":"Способ применения и дозы","value":"Капсулы следует принимать внутрь, проглатывая целиком и запивая водой, желательно во время основного приема пищи.\u003Cbr\u003EКапсулы 2000 ME и 4000 ME\u003Cbr\u003E- Лечение дефицита витамина D (уровень 25(OH)D ≤20 нг/мл) у взрослых - 8000 ME (4 капсулы 2000 ME или 2 капсулы 4000 ME) в сутки в течение 8 недель,\u003Cbr\u003E- Лечение недостаточности витамина D (уровень 25(OH)D - 20-29 нг/мл) у взрослых - 8000 ME (4 капсулы 2000 ME или 2 капсулы 4000 ME) в сутки в течение 4 недель,\u003Cbr\u003E- Поддержание нормального уровня витамина D (уровень 25(OH)D ≥30 нг/мл) у взрослых - 2000 ME (1 капсула) в сутки.\u003Cbr\u003EКапсулы 10000 ME\u003Cbr\u003E- Лечение дефицита витамина D (уровень 25(OH)D ≤20 нг/мл) у взрослых - 50 000 ME (5 капсул 10000 ME) 1 раз в неделю в течение 8 недель,\u003Cbr\u003E- Лечение недостаточности витамина D (уровень 25(OH)D - 20-29 нг/мл) у взрослых - 50 000 ME (5 капсул 10000 ME) 1 раз в неделю в течение 4 недель,\u003Cbr\u003E- Поддержание нормального уровня витамина D (уровень 25(OH)D ≥30 нг/мл) у взрослы - 10000 ME (1 капсула) 1 раз в неделю.\u003Cbr\u003EПри длительном лечении следует регулярно определять концентрацию кальция в крови и моче, а также определять функцию почек путем измерения сывороточной концентрации креатинина. При необходимости доза должна быть скорректирована с учетом концентрации кальция в сыворотке крови.\u003Cbr\u003EЗаболевания печени\u003Cbr\u003EКоррекция дозы не требуется.\u003Cbr\u003EНарушение функции почек\u003Cbr\u003EПрепарат не должен назначаться пациентам с тяжелой почечной недостаточностью."},{"name":"Применение при беременности","value":"Применение препарата Фортедетрим в период беременности и грудного вскармливания не рекомендуется в данных дозировках в связи с превышением рекомендуемой суточной дозой 1000 ME. Во время беременности и в период грудного вскармливания рекомендуется применение препаратов колекальциферола в более низких дозах, например, Аквадетрим."},{"name":"Пол","value":"для женщин"},{"name":"Побочные действия","value":"Классификация частоты нежелательных реакций: нечасто (≥1/1000-\u003C1/100), редко (≥1/10000-\u003C1/1000), неизвестно (на основании имеющихся данных определить частоту невозможно).\u003Cbr\u003EЧастота Неблагоприятные реакции\u003Cbr\u003EНарушения со стороны иммунной системы Неизвестно Реакции гиперчувствительности, такие как ангионевротический отек или отек гортани.\u003Cbr\u003EНарушения со стороны обмена веществ и питания Нечасто Гиперкальциемия или гиперкальциурия.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта Неизвестно Запор, вздутие живота, тошнота, абдоминальная боль, диарея.\u003Cbr\u003EНарушения со стороны кожи и подкожной клетчатки Редко Зуд, сыпь, крапивница."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EПорог интоксикации для колекальциферола варьирует между 40 000 и 100 000 ME в сутки в течение 1-2 месяцев у взрослых с нормальной функцией паращитовидных желез. У новорожденных и маленьких детей может отмечаться чувствительность к гораздо более низким концентрациям.\u003Cbr\u003EОстрая и хроническая передозировка может привести к увеличению уровней фосфора в сыворотке крови и моче, и гиперкальциемии, которая может иметь персистирующий характер и потенциально угрожать жизни.\u003Cbr\u003EТипичные изменения биохимических показателей включают гиперкальциемию, гиперкальциурию, а также повышение в сыворотке крови уровня 25-гидроксикальциферола (25(ОН)D3, кальцидиол). Хроническая передозировка колекальциферолом может привести к отложению кальция в тканях и паренхиматозных органах, прежде всего в почках (мочекаменная болезнь, нефрокальциноз) и сосудах.\u003Cbr\u003EСимптомы носят общий характер и проявляются в виде тошноты, рвоты, также первоначально в виде диареи, позже - в виде запора, потери аппетита, слабости, головной боли, боли в мышцах и суставах, мышечной слабости, азотемии, постоянной сонливости, полидипсии и полиурии и, на завершающей стадии, в виде обезвоживания организма. Передозировка колекальциферолом может вызывать изменения ЭКГ, нарушения ритма сердца, панкреатит, почечную недостаточность.\u003Cbr\u003EЛечение передозировки\u003Cbr\u003EПрежде всего необходимо прекратить прием колекальциферола. Для устранения гиперкальциемии, вызванной передозировкой колекальциферолом, требуется несколько недель. В зависимости от степени гиперкальциемии, в качестве мер лечения назначают диету с низким содержанием кальция или полностью без кальция, потребление большого количества жидкости, форсированный диурез с применением фуросемида, а также глюкокортикостероиды и кальцитонин. При сохранной функции почек концентрация кальция может быть значительно снижена путем инфузии изотонического раствора хлорида натрия (3-6 литров в течение 24 часов) с добавлением фуросемида и, в некоторых случаях, также натрия эдетата в дозе 15 мг/кг/ч, при одновременном мониторинге уровня кальция и данных ЭКГ. Не следует применять инфузию фосфатов для уменьшения гиперкальциемии, вызванной передозировкой колекальциферола, в связи с опасностью развития метастатической кальцификации. При олигоанурии следует провести гемодиализ (диализат без кальция).\u003Cbr\u003EСпецифического антидота не существует.\u003Cbr\u003EРекомендуется обращать внимание пациентов на симптомы возможной передозировки при длительном приеме высоких доз препарата (тошнота, рвота, первоначально - диарея, позже - запор, потеря аппетита, слабость, головная боль, боль в мышцах и суставах, мышечная слабость, постоянная сонливость, полидипсия и полиурия)."},{"name":"Условия хранения","value":"Хранить при температуре не выше 30°С, в оригинальной упаковке (блистер в пачке).\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Особые указания","value":"Если одновременно назначены другие препараты, содержащие колекальциферол, следует учитывать дозу колекальциферола, содержащегося в препарате Фортедетрим. Дополнительное применение колекальциферола или кальция следует проводить только под наблюдением врача. В этом случае необходимо контролировать концентрацию кальция в сыворотке крови и моче. У пациентов с почечной недостаточностью, получающих лечение препаратом Фортедетрим, следует контролировать показатели метаболизма кальция и фосфатов. Препарат не следует применять у пациентов с предрасположенностью к кальциевому нефроуролитиазу.\u003Cbr\u003EПрепарат следует применять с осторожностью у пациентов с нарушенной экскрецией кальция и фосфатов с мочой, при лечении производными бензотиазидина и у иммобилизованных пациентов (риск развития гиперкальциемии и гиперкальциурии). У таких пациентов следует контролировать концентрацию кальция в плазме крови и моче.\u003Cbr\u003EПрепарат не следует принимать при псевдогипопаратиреозе, поскольку в фазе нормальной чувствительности к колекальциферолу потребность в колекальцифероле может уменьшаться, что приводит к риску развития отсроченной передозировки. В таких случаях лучше использовать активные метаболиты витамина D, позволяющие более точно регулировать дозировку.\u003Cbr\u003EПри длительном лечении препаратом Фортедетрим следует контролировать концентрацию кальция в плазме крови и моче, а также проводить оценку функции почек путем измерения концентрации сывороточного креатинина. Это особенно важно для пациентов пожилого возраста и при сопутствующем лечении сердечными гликозидами или диуретиками.\u003Cbr\u003EВ случае развития гиперкальциемии на фоне лечения препаратом Фортедетрим (концентрация кальция в крови превышает 7,5 ммоль/24 ч (300 мг/24 ч) или наличия признаков нарушения функции почек дозу препарата необходимо снизить или приостановить лечение.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EПрием дополнительных количеств колекальциферола и кальция (например, в составе других препаратов), при нарушениях экскреции кальция и фосфатов с мочой, при лечении иммобилизованных пациентов, при одновременном приеме тиазидов, сердечных гликозидов (особенно гликозидов наперстянки), производных бензотиадиазина, у пациентов с атеросклерозом."},{"name":"Владелец регистрационного удостоверения","value":"Polpharma"}]}},"fullSpecsGrouped":{"15280931425944187139":{"groups":[{"name":"Регистрационные данные","items":[{"name":"Дозировка","value":"10000 МЕ"},{"name":"Количество штук в упаковке","value":"30 шт."}]},{"name":"Тип препарата","items":[{"name":"Рецептурный препарат","value":"да"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст","value":"от 18 лет"},{"name":"Форма выпуска","value":"капсулы"}]},{"name":"Применение и информация","items":[{"name":"Действующее вещество","value":"Колекальциферол"},{"name":"Фармакологическая группа","value":"кальциево-фосфорного обмена регулятор"},{"name":"Фармакологическое действие","value":"Витамин D3 является естественной формой витамина D, которая образуется у человека в коже под действием солнечных лучей. По сравнению с витамином D2 характеризуется на 25 % более высокой активностью.\u003Cbr\u003EВитамин D связывается со специфическим рецептором витамина D (VDR), который регулирует экспрессию многих генов, включая гены ионного канала TRPV6 (обеспечивает абсорбцию кальция в кишечнике), CALB1 (кальбиндин; обеспечивает транспорт кальция в кровеносное русло), BGLAP (остеокальцин; обеспечивает минерализацию костной ткани и гомеостаз кальция), SPP1 (остеопонтин; регулирует миграцию остеокластов), REN (ренин; обеспечивает регуляцию артериального давления, являясь ключевым элементом ренин-ангиотензин-альдостероновой системы регуляции), IGFBP (связывающий белок инсулинподобного фактора роста; усиливает действие инсулинподобного фактора роста), FGF23 и FGFR23 (фактор роста фибробластов 23; регулируют уровни кальция, фосфат-аниона, процессы клеточного деления фибробластов), TGFB1 (трансформирующий фактор роста бета-1; регулирует процессы клеточного деления и дифференцировки остеоцитов, хондроцитов, фибробластов и кератиноцитов), LRP2 (ЛПНП-рецептор-связанный белок 2; является посредником эндоцитоза липопротеинов низкой плотности), INSR (рецептор инсулина; обеспечивает эффекты инсулина на любые типы клеток).\u003Cbr\u003EВитамин D3 является активным антирахитическим фактором. Самой важной функцией витамина D3 является регулирование метаболизма кальция и фосфатов, что способствует правильной минерализации и росту скелета.\u003Cbr\u003EКолекальциферол играет существенную роль в абсорбции кальция и фосфатов в кишечнике, в транспорте минеральных солей и в процессе кальцификации костей, регулирует также выведение кальция и фосфатов почками.\u003Cbr\u003EКонцентрация ионов кальция в крови обуславливает поддержание тонуса мышц скелетной мускулатуры, функцию миокарда, способствует проведению нервного возбуждения, регулирует процесс свертывания крови.\u003Cbr\u003EНедостаток витамина D в пище, нарушение его всасывания, дефицит кальция, а также недостаточное пребывание на солнце в период быстрого роста ребенка приводит к рахиту, у взрослых - к остеомаляции, у беременных могут возникнуть симптомы тетании, нарушение процессов обызвествления костей новорожденных.\u003Cbr\u003EПовышенная потребность в витамине D возникает у женщин в период менопаузы, поскольку у них часто развивается остеопороз в связи с гормональными нарушениями. Витамин D обладает рядом т. н. внескелетных эффектов.\u003Cbr\u003EВитамин D участвует в функционировании иммунной системы путем модуляции уровней цитокинов и регулирует деление лимфоцитов Т-хелперов и дифференцировку В-лимфоцитов. В ряде исследований отмечено снижение заболеваемости инфекциями дыхательных путей на фоне приема витамина D.\u003Cbr\u003EПоказано, что витамин D является важным звеном гомеостаза иммунной системы: предотвращает аутоиммунные заболевания (сахарный диабет 1 типа, рассеянный склероз, ревматоидный артрит, воспалительные болезни кишечника и др.).\u003Cbr\u003EВитамин D обладает антипролиферативным и продифференцирующим эффектами, которые обуславливают онкопротективное действие витамина D. Отмечено, что частота некоторых опухолей (рак молочной железы, рак толстого кишечника) повышается на фоне низкого уровня витамина D в крови.\u003Cbr\u003EВитамин D участвует в регуляции углеводного и жирового метаболизма путем влияния на синтез IRS1 (субстрат рецептора инсулина 1; участвует во внутриклеточных путях проведения сигнала рецептора инсулина), IGF (инсулинподобный фактор роста; регулирует баланс жировой и мышечной ткани), PPAR-δ (активированный рецептор пролифераторов пероксисом, тип δ; способствует переработке избыточного холестерина).\u003Cbr\u003EПо данным эпидемиологических исследований дефицит витамина D ассоциирован с риском метаболических нарушений (метаболический синдром и сахарный диабет 2 типа). Рецепторы и метаболизирующие ферменты витамина D экспрессируются в артериальных сосудах, сердце и практически всех клетках и тканях, имеющих отношение к патогенезу сердечно-сосудистых заболеваний. На животных моделях показаны антиатеросклеротическое действие, супрессия ренина и предупреждение повреждения миокарда и др. Низкие уровни витамина D у человека связаны с неблагоприятными факторами риска сердечно-сосудистой патологии, такими как сахарный диабет, дислипидемия, артериальная гипертензия, и ассоциированы с риском сердечно-сосудистых катастроф, в т. ч. инсультов. В исследованиях на экспериментальных моделях болезни Альцгеймера показано, что витамин D3 снижал накопление амилоида в мозге и улучшал когнитивную функцию. В неитервенционных исследованиях у человека показано, что частота развития деменции и болезни Альцгеймера увеличивается на фоне низкого уровня витамина D и низкого диетарного потребления витамина D. Отмечалось ухудшение когнитивной функции и заболеваемости болезнью Альцгеймера при низких уровнях витамина D."},{"name":"Состав","value":"Препарат Фортедетрим содержит:\u003Cbr\u003EДействующим веществом является колекальциферол.\u003Cbr\u003EФортедетрим, 2000 МЕ, капсулы\u003Cbr\u003EКаждая капсула содержит 2000 МЕ колекальциферола.\u003Cbr\u003EПрочими ингредиентами (вспомогательными веществами) является сафлоровое масло рафинированное. Капсула: желатин, глицерол, вода очищенная.\u003Cbr\u003EФортедетрим, 4000 МЕ, капсулы\u003Cbr\u003EКаждая капсула содержит 4000 МЕ колекальциферола.\u003Cbr\u003EПрочими ингредиентами (вспомогательными веществами) является сафлоровое масло рафинированное. Капсула: желатин, глицерол, вода очищенная.\u003Cbr\u003EФортедетрим, 10000 МЕ, капсулы\u003Cbr\u003EКаждая капсула содержит 10000 МЕ колекальциферола.\u003Cbr\u003EПрочими ингредиентами (вспомогательными веществами) является сафлоровое масло рафинированное. Капсула: желатин, глицерол, вода очищенная."},{"name":"Взаимодействие","value":"Одновременный прием противосудорожных лекарственных препаратов (таких как фенитоин) или барбитуратов (и, возможно, других лекарственных средств, индуцирующих ферменты печени) может снизить эффективность колекальциферола за счет увеличения скорости биотрансформации колекальциферола в неактивные метаболиты.\u003Cbr\u003EСопутствующая терапия препаратами глюкокортикостероидов может снижать эффективность колекальциферола.\u003Cbr\u003EПероральный прием колекальциферола может усилить терапевтический эффект и токсический потенциал наперстянки и других сердечных гликозидов (риск развития аритмии) за счет развития гиперкальциемии. Требуется тщательное медицинское наблюдение, контроль показателей ЭКГ и уровней кальция в плазме крови и моче, и, при необходимости, корректировка дозы сердечных гликозидов.\u003Cbr\u003EВ случае сопутствующей терапии тиазидными диуретиками, которые уменьшают экскрецию кальция с мочой, рекомендуется контролировать содержание кальция в сыворотке крови и моче.\u003Cbr\u003EОдновременное лечение ионообменными смолами (такими как колестирамин), препаратами орлистата или слабительными средствами (такими как парафиновое масло) может уменьшать всасывание колекальциферола в пищеварительном тракте. Одновременный прием рифампицина и изониазида может снизить эффективность препарата из-за увеличения скорости биотрансформации колекальциферола.\u003Cbr\u003EНа фоне одновременного приема антацидов, содержащих магний, и колекальциферола может повышаться концентрация магния в крови.\u003Cbr\u003EНа фоне одновременного приема антацидов, содержащих алюминий, и колекальциферола может повышаться концентрация алюминия в крови, что увеличивает риск токсического воздействия алюминия."},{"name":"Показания к применению","value":"Лечение и профилактика дефицита и недостаточности витамина D и состояний, вызванных дефицитом витамина D у взрослых."},{"name":"Противопоказания","value":"-повышенная чувствительность к действующему веществу или любому из вспомогательных веществ, перечисленных в разделе \"Состав\";\u003Cbr\u003E-гиперкальциемия и (или) гиперкальциурия;\u003Cbr\u003E-мочекаменная болезнь (образование кальциевых оксалатных камней);\u003Cbr\u003E-гипервитаминоз D;\u003Cbr\u003E-псевдогипопаратиреоз;\u003Cbr\u003E-саркоидоз;\u003Cbr\u003E-активная форма туберкулеза легких;\u003Cbr\u003E-тяжелая почечная недостаточность;\u003Cbr\u003E-беременность и период грудного вскармливания (в данных дозировках);\u003Cbr\u003E-детский возраст до 18 лет."},{"name":"Способ применения и дозы","value":"Капсулы следует принимать внутрь, проглатывая целиком и запивая водой, желательно во время основного приема пищи.\u003Cbr\u003EКапсулы 2000 ME и 4000 ME\u003Cbr\u003E- Лечение дефицита витамина D (уровень 25(OH)D ≤20 нг/мл) у взрослых - 8000 ME (4 капсулы 2000 ME или 2 капсулы 4000 ME) в сутки в течение 8 недель,\u003Cbr\u003E- Лечение недостаточности витамина D (уровень 25(OH)D - 20-29 нг/мл) у взрослых - 8000 ME (4 капсулы 2000 ME или 2 капсулы 4000 ME) в сутки в течение 4 недель,\u003Cbr\u003E- Поддержание нормального уровня витамина D (уровень 25(OH)D ≥30 нг/мл) у взрослых - 2000 ME (1 капсула) в сутки.\u003Cbr\u003EКапсулы 10000 ME\u003Cbr\u003E- Лечение дефицита витамина D (уровень 25(OH)D ≤20 нг/мл) у взрослых - 50 000 ME (5 капсул 10000 ME) 1 раз в неделю в течение 8 недель,\u003Cbr\u003E- Лечение недостаточности витамина D (уровень 25(OH)D - 20-29 нг/мл) у взрослых - 50 000 ME (5 капсул 10000 ME) 1 раз в неделю в течение 4 недель,\u003Cbr\u003E- Поддержание нормального уровня витамина D (уровень 25(OH)D ≥30 нг/мл) у взрослы - 10000 ME (1 капсула) 1 раз в неделю.\u003Cbr\u003EПри длительном лечении следует регулярно определять концентрацию кальция в крови и моче, а также определять функцию почек путем измерения сывороточной концентрации креатинина. При необходимости доза должна быть скорректирована с учетом концентрации кальция в сыворотке крови.\u003Cbr\u003EЗаболевания печени\u003Cbr\u003EКоррекция дозы не требуется.\u003Cbr\u003EНарушение функции почек\u003Cbr\u003EПрепарат не должен назначаться пациентам с тяжелой почечной недостаточностью."},{"name":"Применение при беременности","value":"Применение препарата Фортедетрим в период беременности и грудного вскармливания не рекомендуется в данных дозировках в связи с превышением рекомендуемой суточной дозой 1000 ME. Во время беременности и в период грудного вскармливания рекомендуется применение препаратов колекальциферола в более низких дозах, например, Аквадетрим."},{"name":"Пол","value":"для женщин"},{"name":"Побочные действия","value":"Классификация частоты нежелательных реакций: нечасто (≥1/1000-\u003C1/100), редко (≥1/10000-\u003C1/1000), неизвестно (на основании имеющихся данных определить частоту невозможно).\u003Cbr\u003EЧастота Неблагоприятные реакции\u003Cbr\u003EНарушения со стороны иммунной системы Неизвестно Реакции гиперчувствительности, такие как ангионевротический отек или отек гортани.\u003Cbr\u003EНарушения со стороны обмена веществ и питания Нечасто Гиперкальциемия или гиперкальциурия.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта Неизвестно Запор, вздутие живота, тошнота, абдоминальная боль, диарея.\u003Cbr\u003EНарушения со стороны кожи и подкожной клетчатки Редко Зуд, сыпь, крапивница."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EПорог интоксикации для колекальциферола варьирует между 40 000 и 100 000 ME в сутки в течение 1-2 месяцев у взрослых с нормальной функцией паращитовидных желез. У новорожденных и маленьких детей может отмечаться чувствительность к гораздо более низким концентрациям.\u003Cbr\u003EОстрая и хроническая передозировка может привести к увеличению уровней фосфора в сыворотке крови и моче, и гиперкальциемии, которая может иметь персистирующий характер и потенциально угрожать жизни.\u003Cbr\u003EТипичные изменения биохимических показателей включают гиперкальциемию, гиперкальциурию, а также повышение в сыворотке крови уровня 25-гидроксикальциферола (25(ОН)D3, кальцидиол). Хроническая передозировка колекальциферолом может привести к отложению кальция в тканях и паренхиматозных органах, прежде всего в почках (мочекаменная болезнь, нефрокальциноз) и сосудах.\u003Cbr\u003EСимптомы носят общий характер и проявляются в виде тошноты, рвоты, также первоначально в виде диареи, позже - в виде запора, потери аппетита, слабости, головной боли, боли в мышцах и суставах, мышечной слабости, азотемии, постоянной сонливости, полидипсии и полиурии и, на завершающей стадии, в виде обезвоживания организма. Передозировка колекальциферолом может вызывать изменения ЭКГ, нарушения ритма сердца, панкреатит, почечную недостаточность.\u003Cbr\u003EЛечение передозировки\u003Cbr\u003EПрежде всего необходимо прекратить прием колекальциферола. Для устранения гиперкальциемии, вызванной передозировкой колекальциферолом, требуется несколько недель. В зависимости от степени гиперкальциемии, в качестве мер лечения назначают диету с низким содержанием кальция или полностью без кальция, потребление большого количества жидкости, форсированный диурез с применением фуросемида, а также глюкокортикостероиды и кальцитонин. При сохранной функции почек концентрация кальция может быть значительно снижена путем инфузии изотонического раствора хлорида натрия (3-6 литров в течение 24 часов) с добавлением фуросемида и, в некоторых случаях, также натрия эдетата в дозе 15 мг/кг/ч, при одновременном мониторинге уровня кальция и данных ЭКГ. Не следует применять инфузию фосфатов для уменьшения гиперкальциемии, вызванной передозировкой колекальциферола, в связи с опасностью развития метастатической кальцификации. При олигоанурии следует провести гемодиализ (диализат без кальция).\u003Cbr\u003EСпецифического антидота не существует.\u003Cbr\u003EРекомендуется обращать внимание пациентов на симптомы возможной передозировки при длительном приеме высоких доз препарата (тошнота, рвота, первоначально - диарея, позже - запор, потеря аппетита, слабость, головная боль, боль в мышцах и суставах, мышечная слабость, постоянная сонливость, полидипсия и полиурия)."},{"name":"Условия хранения","value":"Хранить при температуре не выше 30°С, в оригинальной упаковке (блистер в пачке).\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Особые указания","value":"Если одновременно назначены другие препараты, содержащие колекальциферол, следует учитывать дозу колекальциферола, содержащегося в препарате Фортедетрим. Дополнительное применение колекальциферола или кальция следует проводить только под наблюдением врача. В этом случае необходимо контролировать концентрацию кальция в сыворотке крови и моче. У пациентов с почечной недостаточностью, получающих лечение препаратом Фортедетрим, следует контролировать показатели метаболизма кальция и фосфатов. Препарат не следует применять у пациентов с предрасположенностью к кальциевому нефроуролитиазу.\u003Cbr\u003EПрепарат следует применять с осторожностью у пациентов с нарушенной экскрецией кальция и фосфатов с мочой, при лечении производными бензотиазидина и у иммобилизованных пациентов (риск развития гиперкальциемии и гиперкальциурии). У таких пациентов следует контролировать концентрацию кальция в плазме крови и моче.\u003Cbr\u003EПрепарат не следует принимать при псевдогипопаратиреозе, поскольку в фазе нормальной чувствительности к колекальциферолу потребность в колекальцифероле может уменьшаться, что приводит к риску развития отсроченной передозировки. В таких случаях лучше использовать активные метаболиты витамина D, позволяющие более точно регулировать дозировку.\u003Cbr\u003EПри длительном лечении препаратом Фортедетрим следует контролировать концентрацию кальция в плазме крови и моче, а также проводить оценку функции почек путем измерения концентрации сывороточного креатинина. Это особенно важно для пациентов пожилого возраста и при сопутствующем лечении сердечными гликозидами или диуретиками.\u003Cbr\u003EВ случае развития гиперкальциемии на фоне лечения препаратом Фортедетрим (концентрация кальция в крови превышает 7,5 ммоль/24 ч (300 мг/24 ч) или наличия признаков нарушения функции почек дозу препарата необходимо снизить или приостановить лечение.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EПрием дополнительных количеств колекальциферола и кальция (например, в составе других препаратов), при нарушениях экскреции кальция и фосфатов с мочой, при лечении иммобилизованных пациентов, при одновременном приеме тиазидов, сердечных гликозидов (особенно гликозидов наперстянки), производных бензотиадиазина, у пациентов с атеросклерозом."},{"name":"Владелец регистрационного удостоверения","value":"Polpharma"}]}],"transitionId":"tr_808895894196041988"}}}}
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54 ₽/шт

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По сравнению с витамином D2 характеризуется на 25 % более высокой активностью.\u003Cbr\u003EВитамин D связывается со специфическим рецептором витамина D (VDR), который регулирует экспрессию многих генов, включая гены ионного канала TRPV6 (обеспечивает абсорбцию кальция в кишечнике), CALB1 (кальбиндин; обеспечивает транспорт кальция в кровеносное русло), BGLAP (остеокальцин; обеспечивает минерализацию костной ткани и гомеостаз кальция), SPP1 (остеопонтин; регулирует миграцию остеокластов), REN (ренин; обеспечивает регуляцию артериального давления, являясь ключевым элементом ренин-ангиотензин-альдостероновой системы регуляции), IGFBP (связывающий белок инсулинподобного фактора роста; усиливает действие инсулинподобного фактора роста), FGF23 и FGFR23 (фактор роста фибробластов 23; регулируют уровни кальция, фосфат-аниона, процессы клеточного деления фибробластов), TGFB1 (трансформирующий фактор роста бета-1; регулирует процессы клеточного деления и дифференцировки остеоцитов, хондроцитов, фибробластов и кератиноцитов), LRP2 (ЛПНП-рецептор-связанный белок 2; является посредником эндоцитоза липопротеинов низкой плотности), INSR (рецептор инсулина; обеспечивает эффекты инсулина на любые типы клеток).\u003Cbr\u003EВитамин D3 является активным антирахитическим фактором. Самой важной функцией витамина D3 является регулирование метаболизма кальция и фосфатов, что способствует правильной минерализации и росту скелета.\u003Cbr\u003EКолекальциферол играет существенную роль в абсорбции кальция и фосфатов в кишечнике, в транспорте минеральных солей и в процессе кальцификации костей, регулирует также выведение кальция и фосфатов почками.\u003Cbr\u003EКонцентрация ионов кальция в крови обуславливает поддержание тонуса мышц скелетной мускулатуры, функцию миокарда, способствует проведению нервного возбуждения, регулирует процесс свертывания крови.\u003Cbr\u003EНедостаток витамина D в пище, нарушение его всасывания, дефицит кальция, а также недостаточное пребывание на солнце в период быстрого роста ребенка приводит к рахиту, у взрослых - к остеомаляции, у беременных могут возникнуть симптомы тетании, нарушение процессов обызвествления костей новорожденных.\u003Cbr\u003EПовышенная потребность в витамине D возникает у женщин в период менопаузы, поскольку у них часто развивается остеопороз в связи с гормональными нарушениями. Витамин D обладает рядом т. н. внескелетных эффектов.\u003Cbr\u003EВитамин D участвует в функционировании иммунной системы путем модуляции уровней цитокинов и регулирует деление лимфоцитов Т-хелперов и дифференцировку В-лимфоцитов. В ряде исследований отмечено снижение заболеваемости инфекциями дыхательных путей на фоне приема витамина D.\u003Cbr\u003EПоказано, что витамин D является важным звеном гомеостаза иммунной системы: предотвращает аутоиммунные заболевания (сахарный диабет 1 типа, рассеянный склероз, ревматоидный артрит, воспалительные болезни кишечника и др.).\u003Cbr\u003EВитамин D обладает антипролиферативным и продифференцирующим эффектами, которые обуславливают онкопротективное действие витамина D. Отмечено, что частота некоторых опухолей (рак молочной железы, рак толстого кишечника) повышается на фоне низкого уровня витамина D в крови.\u003Cbr\u003EВитамин D участвует в регуляции углеводного и жирового метаболизма путем влияния на синтез IRS1 (субстрат рецептора инсулина 1; участвует во внутриклеточных путях проведения сигнала рецептора инсулина), IGF (инсулинподобный фактор роста; регулирует баланс жировой и мышечной ткани), PPAR-δ (активированный рецептор пролифераторов пероксисом, тип δ; способствует переработке избыточного холестерина).\u003Cbr\u003EПо данным эпидемиологических исследований дефицит витамина D ассоциирован с риском метаболических нарушений (метаболический синдром и сахарный диабет 2 типа). Рецепторы и метаболизирующие ферменты витамина D экспрессируются в артериальных сосудах, сердце и практически всех клетках и тканях, имеющих отношение к патогенезу сердечно-сосудистых заболеваний. На животных моделях показаны антиатеросклеротическое действие, супрессия ренина и предупреждение повреждения миокарда и др. Низкие уровни витамина D у человека связаны с неблагоприятными факторами риска сердечно-сосудистой патологии, такими как сахарный диабет, дислипидемия, артериальная гипертензия, и ассоциированы с риском сердечно-сосудистых катастроф, в т. ч. инсультов. В исследованиях на экспериментальных моделях болезни Альцгеймера показано, что витамин D3 снижал накопление амилоида в мозге и улучшал когнитивную функцию. В неитервенционных исследованиях у человека показано, что частота развития деменции и болезни Альцгеймера увеличивается на фоне низкого уровня витамина D и низкого диетарного потребления витамина D. Отмечалось ухудшение когнитивной функции и заболеваемости болезнью Альцгеймера при низких уровнях витамина D."},{"description":"","filters":[{"id":50921473,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"Препарат Фортедетрим содержит:\u003Cbr\u003EДействующим веществом является колекальциферол.\u003Cbr\u003EФортедетрим, 2000 МЕ, капсулы\u003Cbr\u003EКаждая капсула содержит 2000 МЕ колекальциферола.\u003Cbr\u003EПрочими ингредиентами (вспомогательными веществами) является сафлоровое масло рафинированное. Капсула: желатин, глицерол, вода очищенная.\u003Cbr\u003EФортедетрим, 4000 МЕ, капсулы\u003Cbr\u003EКаждая капсула содержит 4000 МЕ колекальциферола.\u003Cbr\u003EПрочими ингредиентами (вспомогательными веществами) является сафлоровое масло рафинированное. Капсула: желатин, глицерол, вода очищенная.\u003Cbr\u003EФортедетрим, 10000 МЕ, капсулы\u003Cbr\u003EКаждая капсула содержит 10000 МЕ колекальциферола.\u003Cbr\u003EПрочими ингредиентами (вспомогательными веществами) является сафлоровое масло рафинированное. Капсула: желатин, глицерол, вода очищенная."},{"description":"","filters":[{"id":50921347,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Одновременный прием противосудорожных лекарственных препаратов (таких как фенитоин) или барбитуратов (и, возможно, других лекарственных средств, индуцирующих ферменты печени) может снизить эффективность колекальциферола за счет увеличения скорости биотрансформации колекальциферола в неактивные метаболиты.\u003Cbr\u003EСопутствующая терапия препаратами глюкокортикостероидов может снижать эффективность колекальциферола.\u003Cbr\u003EПероральный прием колекальциферола может усилить терапевтический эффект и токсический потенциал наперстянки и других сердечных гликозидов (риск развития аритмии) за счет развития гиперкальциемии. Требуется тщательное медицинское наблюдение, контроль показателей ЭКГ и уровней кальция в плазме крови и моче, и, при необходимости, корректировка дозы сердечных гликозидов.\u003Cbr\u003EВ случае сопутствующей терапии тиазидными диуретиками, которые уменьшают экскрецию кальция с мочой, рекомендуется контролировать содержание кальция в сыворотке крови и моче.\u003Cbr\u003EОдновременное лечение ионообменными смолами (такими как колестирамин), препаратами орлистата или слабительными средствами (такими как парафиновое масло) может уменьшать всасывание колекальциферола в пищеварительном тракте. Одновременный прием рифампицина и изониазида может снизить эффективность препарата из-за увеличения скорости биотрансформации колекальциферола.\u003Cbr\u003EНа фоне одновременного приема антацидов, содержащих магний, и колекальциферола может повышаться концентрация магния в крови.\u003Cbr\u003EНа фоне одновременного приема антацидов, содержащих алюминий, и колекальциферола может повышаться концентрация алюминия в крови, что увеличивает риск токсического воздействия алюминия."},{"description":"","filters":[{"id":50921465,"name":"Показания к применению"}],"isMainProperty":false,"name":"Показания к применению","value":"Лечение и профилактика дефицита и недостаточности витамина D и состояний, вызванных дефицитом витамина D у взрослых."},{"description":"","filters":[{"id":50925451,"name":"Противопоказания"}],"isMainProperty":false,"name":"Противопоказания","value":"-повышенная чувствительность к действующему веществу или любому из вспомогательных веществ, перечисленных в разделе \"Состав\";\u003Cbr\u003E-гиперкальциемия и (или) гиперкальциурия;\u003Cbr\u003E-мочекаменная болезнь (образование кальциевых оксалатных камней);\u003Cbr\u003E-гипервитаминоз D;\u003Cbr\u003E-псевдогипопаратиреоз;\u003Cbr\u003E-саркоидоз;\u003Cbr\u003E-активная форма туберкулеза легких;\u003Cbr\u003E-тяжелая почечная недостаточность;\u003Cbr\u003E-беременность и период грудного вскармливания (в данных дозировках);\u003Cbr\u003E-детский возраст до 18 лет."},{"description":"","filters":[{"id":50921469,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Капсулы следует принимать внутрь, проглатывая целиком и запивая водой, желательно во время основного приема пищи.\u003Cbr\u003EКапсулы 2000 ME и 4000 ME\u003Cbr\u003E- Лечение дефицита витамина D (уровень 25(OH)D ≤20 нг/мл) у взрослых - 8000 ME (4 капсулы 2000 ME или 2 капсулы 4000 ME) в сутки в течение 8 недель,\u003Cbr\u003E- Лечение недостаточности витамина D (уровень 25(OH)D - 20-29 нг/мл) у взрослых - 8000 ME (4 капсулы 2000 ME или 2 капсулы 4000 ME) в сутки в течение 4 недель,\u003Cbr\u003E- Поддержание нормального уровня витамина D (уровень 25(OH)D ≥30 нг/мл) у взрослых - 2000 ME (1 капсула) в сутки.\u003Cbr\u003EКапсулы 10000 ME\u003Cbr\u003E- Лечение дефицита витамина D (уровень 25(OH)D ≤20 нг/мл) у взрослых - 50 000 ME (5 капсул 10000 ME) 1 раз в неделю в течение 8 недель,\u003Cbr\u003E- Лечение недостаточности витамина D (уровень 25(OH)D - 20-29 нг/мл) у взрослых - 50 000 ME (5 капсул 10000 ME) 1 раз в неделю в течение 4 недель,\u003Cbr\u003E- Поддержание нормального уровня витамина D (уровень 25(OH)D ≥30 нг/мл) у взрослы - 10000 ME (1 капсула) 1 раз в неделю.\u003Cbr\u003EПри длительном лечении следует регулярно определять концентрацию кальция в крови и моче, а также определять функцию почек путем измерения сывороточной концентрации креатинина. При необходимости доза должна быть скорректирована с учетом концентрации кальция в сыворотке крови.\u003Cbr\u003EЗаболевания печени\u003Cbr\u003EКоррекция дозы не требуется.\u003Cbr\u003EНарушение функции почек\u003Cbr\u003EПрепарат не должен назначаться пациентам с тяжелой почечной недостаточностью."},{"description":"","filters":[{"id":50921474,"name":"Применение при беременности"}],"isMainProperty":false,"name":"Применение при беременности","value":"Применение препарата Фортедетрим в период беременности и грудного вскармливания не рекомендуется в данных дозировках в связи с превышением рекомендуемой суточной дозой 1000 ME. Во время беременности и в период грудного вскармливания рекомендуется применение препаратов колекальциферола в более низких дозах, например, Аквадетрим."},{"description":"","filters":[{"id":14805991,"name":"Пол"}],"isMainProperty":false,"name":"Пол","value":"для женщин"},{"description":"","filters":[{"id":50921464,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Классификация частоты нежелательных реакций: нечасто (≥1/1000-\u003C1/100), редко (≥1/10000-\u003C1/1000), неизвестно (на основании имеющихся данных определить частоту невозможно).\u003Cbr\u003EЧастота Неблагоприятные реакции\u003Cbr\u003EНарушения со стороны иммунной системы Неизвестно Реакции гиперчувствительности, такие как ангионевротический отек или отек гортани.\u003Cbr\u003EНарушения со стороны обмена веществ и питания Нечасто Гиперкальциемия или гиперкальциурия.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта Неизвестно Запор, вздутие живота, тошнота, абдоминальная боль, диарея.\u003Cbr\u003EНарушения со стороны кожи и подкожной клетчатки Редко Зуд, сыпь, крапивница."},{"description":"","filters":[{"id":50921468,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Симптомы\u003Cbr\u003EПорог интоксикации для колекальциферола варьирует между 40 000 и 100 000 ME в сутки в течение 1-2 месяцев у взрослых с нормальной функцией паращитовидных желез. У новорожденных и маленьких детей может отмечаться чувствительность к гораздо более низким концентрациям.\u003Cbr\u003EОстрая и хроническая передозировка может привести к увеличению уровней фосфора в сыворотке крови и моче, и гиперкальциемии, которая может иметь персистирующий характер и потенциально угрожать жизни.\u003Cbr\u003EТипичные изменения биохимических показателей включают гиперкальциемию, гиперкальциурию, а также повышение в сыворотке крови уровня 25-гидроксикальциферола (25(ОН)D3, кальцидиол). Хроническая передозировка колекальциферолом может привести к отложению кальция в тканях и паренхиматозных органах, прежде всего в почках (мочекаменная болезнь, нефрокальциноз) и сосудах.\u003Cbr\u003EСимптомы носят общий характер и проявляются в виде тошноты, рвоты, также первоначально в виде диареи, позже - в виде запора, потери аппетита, слабости, головной боли, боли в мышцах и суставах, мышечной слабости, азотемии, постоянной сонливости, полидипсии и полиурии и, на завершающей стадии, в виде обезвоживания организма. Передозировка колекальциферолом может вызывать изменения ЭКГ, нарушения ритма сердца, панкреатит, почечную недостаточность.\u003Cbr\u003EЛечение передозировки\u003Cbr\u003EПрежде всего необходимо прекратить прием колекальциферола. Для устранения гиперкальциемии, вызванной передозировкой колекальциферолом, требуется несколько недель. В зависимости от степени гиперкальциемии, в качестве мер лечения назначают диету с низким содержанием кальция или полностью без кальция, потребление большого количества жидкости, форсированный диурез с применением фуросемида, а также глюкокортикостероиды и кальцитонин. При сохранной функции почек концентрация кальция может быть значительно снижена путем инфузии изотонического раствора хлорида натрия (3-6 литров в течение 24 часов) с добавлением фуросемида и, в некоторых случаях, также натрия эдетата в дозе 15 мг/кг/ч, при одновременном мониторинге уровня кальция и данных ЭКГ. Не следует применять инфузию фосфатов для уменьшения гиперкальциемии, вызванной передозировкой колекальциферола, в связи с опасностью развития метастатической кальцификации. При олигоанурии следует провести гемодиализ (диализат без кальция).\u003Cbr\u003EСпецифического антидота не существует.\u003Cbr\u003EРекомендуется обращать внимание пациентов на симптомы возможной передозировки при длительном приеме высоких доз препарата (тошнота, рвота, первоначально - диарея, позже - запор, потеря аппетита, слабость, головная боль, боль в мышцах и суставах, мышечная слабость, постоянная сонливость, полидипсия и полиурия)."},{"description":"","filters":[{"id":50921467,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Хранить при температуре не выше 30°С, в оригинальной упаковке (блистер в пачке).\u003Cbr\u003EХранить в недоступном для детей месте."},{"description":"","filters":[{"id":50921466,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Если одновременно назначены другие препараты, содержащие колекальциферол, следует учитывать дозу колекальциферола, содержащегося в препарате Фортедетрим. Дополнительное применение колекальциферола или кальция следует проводить только под наблюдением врача. В этом случае необходимо контролировать концентрацию кальция в сыворотке крови и моче. У пациентов с почечной недостаточностью, получающих лечение препаратом Фортедетрим, следует контролировать показатели метаболизма кальция и фосфатов. Препарат не следует применять у пациентов с предрасположенностью к кальциевому нефроуролитиазу.\u003Cbr\u003EПрепарат следует применять с осторожностью у пациентов с нарушенной экскрецией кальция и фосфатов с мочой, при лечении производными бензотиазидина и у иммобилизованных пациентов (риск развития гиперкальциемии и гиперкальциурии). 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    Цена 1 563 ₽ вместо 1 979
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  • Аквадетрим капли д/вн.приема фл.-капельница, 1 шт.
    –1 %
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    Аквадетрим капли д/вн.приема фл.-капельница, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 107 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 296 ₽ вместо 299
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  • Вигантол р-р д/вн. приема масл., 1 шт.
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    Вигантол р-р д/вн. приема масл., 1 шт.

    Рейтинг товара: 4.8 из 5
    на основе 99 оценок
    Цена 184 ₽
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  • Аквадетрим капли д/вн. приема фл.-капельница, 1 шт.
    –18 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ivxknq592df/toggleWishlist":{"skuId":"101306990794","productId":226182684,"offerId":"BZ8J7t4uww-I6j2QNwtpfQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCJyM7WsQyoH4svkCGKrGngggnP6jGA==","sign":"6dqxKAV58867R9HGeRiog9QQN0zY+A2Ik8EeqAmf6YY="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ivxknq592df/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Аквадетрим капли д/вн. приема фл.-капельница, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 124 оценки
    Цена 222 ₽ вместо 272
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  • Сорбифер дурулес таб. п/о, 30 шт.
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    Сорбифер дурулес таб. п/о, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 96 оценок
    Цена 701 ₽
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  • Тотема р-р д/вн. приема, 20 шт.
    –21 %
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    Тотема р-р д/вн. приема, 20 шт.

    Рейтинг товара: 4.8 из 5
    на основе 22 оценки
    Цена 708 ₽ вместо 897
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  • Магне B6 таб. п/о, 100 шт.
    –34 %
    ПРОМОКОД –15 %
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    Магне B6 таб. п/о, 100 шт.

    Рейтинг товара: 4.9 из 5
    на основе 176 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 797 ₽ вместо 805
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B6 таб. п/о, 100 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  • Аквадетрим таб. раств., 2000 ME, 60 шт.
    ВАМ–13 %
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    Аквадетрим таб. раств., 2000 ME, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 6 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 637 ₽ вместо 643
    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  • Феррум лек р-р д/ин., 50 мг/мл, 5 шт.
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    Феррум лек р-р д/ин., 50 мг/мл, 5 шт.

    Рейтинг товара: 5 из 5
    на основе 33 оценки
    Цена 1 899 ₽
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  • Супрадин таб. п/о, 30 шт.
    –24 %
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    Супрадин таб. п/о, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 151 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 856 ₽ вместо 865
    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  • Аскорутин таб., 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-foxk8lt8aqq/toggleWishlist":{"skuId":"101300866742","productId":228001838,"offerId":"7GWhH5T5HkIaD4wzW-jntw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIWCK6Q3GwQtp2CsPkCGK7C2QcgnP6jGA==","sign":"Tmf4Y3bjc/8EbIBcqfcXtXZ2cugQcETTaXk9ytfm/Xk="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-foxk8lt8aqq/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Аскорутин таб., 50 шт.

    Рейтинг товара: 4.9 из 5
    на основе 253 оценки
    Цена 49 ₽
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  • Магнелис B6 таб. п/о, 120 шт.
    –1 %
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    Магнелис B6 таб. п/о, 120 шт.

    Рейтинг товара: 5 из 5
    на основе 119 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 954 ₽ вместо 964
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{"widgets":{"@light/ScrollBoxControls":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/controls":{"parentId":"ulczh6gnqc","itemsCount":12,"ratio":[2,13],"withScrollBoxGap":false,"gapWidth":4,"rightButtonOffset":0,"leftButtonOffset":0}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/controls":{"name":"@light/ScrollBoxControls"}}}

Инструкция

Показания к применению

Лечение и профилактика дефицита и недостаточности витамина D и состояний, вызванных дефицитом витамина D у взрослых.

Противопоказания

-повышенная чувствительность к действующему веществу или любому из вспомогательных веществ, перечисленных в разделе "Состав";
-гиперкальциемия и (или) гиперкальциурия;
-мочекаменная болезнь (образование кальциевых оксалатных камней);
-гипервитаминоз D;
-псевдогипопаратиреоз;
-саркоидоз;
-активная форма туберкулеза легких;
-тяжелая почечная недостаточность;
-беременность и период грудного вскармливания (в данных дозировках);
-детский возраст до 18 лет.

Способ применения и дозы

Капсулы следует принимать внутрь, проглатывая целиком и запивая водой, желательно во время основного приема пищи.
Капсулы 2000 ME и 4000 ME
- Лечение дефицита витамина D (уровень 25(OH)D ≤20 нг/мл) у взрослых - 8000 ME (4 капсулы 2000 ME или 2 капсулы 4000 ME) в сутки в течение 8 недель,
- Лечение недостаточности витамина D (уровень 25(OH)D - 20-29 нг/мл) у взрослых - 8000 ME (4 капсулы 2000 ME или 2 капсулы 4000 ME) в сутки в течение 4 недель,
- Поддержание нормального уровня витамина D (уровень 25(OH)D ≥30 нг/мл) у взрослых - 2000 ME (1 капсула) в сутки.
Капсулы 10000 ME
- Лечение дефицита витамина D (уровень 25(OH)D ≤20 нг/мл) у взрослых - 50 000 ME (5 капсул 10000 ME) 1 раз в неделю в течение 8 недель,
- Лечение недостаточности витамина D (уровень 25(OH)D - 20-29 нг/мл) у взрослых - 50 000 ME (5 капсул 10000 ME) 1 раз в неделю в течение 4 недель,
- Поддержание нормального уровня витамина D (уровень 25(OH)D ≥30 нг/мл) у взрослы - 10000 ME (1 капсула) 1 раз в неделю.
При длительном лечении следует регулярно определять концентрацию кальция в крови и моче, а также определять функцию почек путем измерения сывороточной концентрации креатинина. При необходимости доза должна быть скорректирована с учетом концентрации кальция в сыворотке крови.
Заболевания печени
Коррекция дозы не требуется.
Нарушение функции почек
Препарат не должен назначаться пациентам с тяжелой почечной недостаточностью.
Полная инструкция
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Фортедетрим капс.
Фортедетрим капс., 10000 МЕ, 30 шт.
4.8
(77)
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3 вопроса
Инструкция

1 609 ₽/уп

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user avatar
27 апреля • Олеся Кузнецова
Достоинства: ДозировкаНедостатки: Пока не обнзКомментарий: Назначили, посмотрим через три месяца что из этого выйдет
user avatar
23 апреля • Feldposten
Комментарий: Супер
user avatar
5 марта • Игорь Макаров
Достоинства: Мы принимаем его по врачебному предписанию.Недостатки: НЕ заметил.Комментарий: Витамин Д3 поддерживает нас в этот период зимы.
user avatar
22 января • Имя скрыто
Комментарий: Хорошо усваивается.
user avatar
24 декабря 2023 • Мария Н.
Достоинства: ОтличноеНедостатки: НетуКомментарий: Купила по совету врача.Отличное средство и здесь ещё и по скидке купила.Рекомендую.Восполняет дефицит витамина в организме
user avatar
20 декабря 2023 • Алешка
Достоинства: для здоровьяНедостатки: нетКомментарий: прописал врач для моей мамы . так как у неё остопароз и нехватка витамина D. да и в целом много полезных своиств этого препарата.
user avatar
18 декабря 2023 • Оля Т.
Достоинства: Хорошо усваивается. По анализам всё ок.Недостатки: НетКомментарий: Доставили быстро, упаковка целая.
user avatar
16 декабря 2023 • Екатерина Кельина
Достоинства: удобная форма и дозировка. а то постоянно забываю выпить таблетку.
user avatar
16 декабря 2023 • Альбек Абраев
Достоинства: всё пришло вовремя, спасибоНедостатки: нетКомментарий: в аптеке отсутствовал этот препарат,где я живу,а тут прям выручили!!!
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  • Омакор капс., 1000 мг, 28 шт.
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    Омакор капс., 1000 мг, 28 шт.

    Цена 2 098 ₽ вместо 2 358
  • Фортедетрим капс., 10000 МЕ, 30 шт.
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    Фортедетрим капс., 10000 МЕ, 30 шт.

    Цена 1 563 ₽ вместо 1 979
  • Налемарин капс., 65 г, 60 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:968868011_2/content/content/toggleWishlist":{"skuId":"101333033761","productId":968868011,"offerId":"usY737I9vT9j9a5o9QDfNQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFgirgf/NAxChxq2/+QIYutOECyCZwwU=","sign":"Y9/2+wAGwf3pSEO+6RoBdX8RSGRHBucbBeAgtbBhCU0="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:968868011_2/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Налемарин капс., 65 г, 60 шт.

    Цена 1 284 ₽ вместо 1 900
  • Аквадетрим капли д/вн.приема фл.-капельница, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1463723511_3/content/content/gallery":{"title":"Аквадетрим капли д/вн.приема фл.-капельница, 1 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/1928572/img_id8877125424287855599.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1928572/img_id8877125424287855599.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1928572/img_id8877125424287855599.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1928572/img_id8877125424287855599.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1928572/img_id8877125424287855599.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1928572/img_id8877125424287855599.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5214322/img_id7472930258963582332.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5214322/img_id7472930258963582332.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5214322/img_id7472930258963582332.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5214322/img_id7472930258963582332.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5214322/img_id7472930258963582332.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5214322/img_id7472930258963582332.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4441663/img_id2526872256627730415.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4441663/img_id2526872256627730415.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4441663/img_id2526872256627730415.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4441663/img_id2526872256627730415.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4441663/img_id2526872256627730415.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4441663/img_id2526872256627730415.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4547325/img_id8982835078105776713.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4547325/img_id8982835078105776713.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4547325/img_id8982835078105776713.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4547325/img_id8982835078105776713.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4547325/img_id8982835078105776713.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4547325/img_id8982835078105776713.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFwj3y/q5BRCs4q65+wIYud3QByCc/qMY","sign":"xaYYZSl1GtqSv6L5v7+qDHmk8hgtMpzzQsdnAI+S4q4="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1463723511_3/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Аквадетрим капли д/вн.приема фл.-капельница, 1 шт.

    Цена 296 ₽ вместо 299
  • Вигантол р-р д/вн. приема масл., 1 шт.
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    Вигантол р-р д/вн. приема масл., 1 шт.

    Цена 184 ₽
  • Аквадетрим капли д/вн. приема фл.-капельница, 1 шт.
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    Аквадетрим капли д/вн. приема фл.-капельница, 1 шт.

    Цена 222 ₽ вместо 272
  • Омега-3 капс., 1000 мг, 60 г, 60 шт.
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    Омега-3 капс., 1000 мг, 60 г, 60 шт.

    Цена 1 950 ₽ вместо 2 490
  • ВитаФерр капс., 35 г, 30 шт.
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    ВитаФерр капс., 35 г, 30 шт.

    Цена 732 ₽ вместо 739
  • Реклама
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  • Омега-3 Форте капс., 60 шт.
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    Омега-3 Форте капс., 60 шт.

    Цена 2 075 ₽ вместо 3 130
  • Gentle Iron (Iron Bisglycinate) капс., 25 мг, 15 г, 90 шт.
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    Gentle Iron (Iron Bisglycinate) капс., 25 мг, 15 г, 90 шт.

    Цена 1 376 ₽ вместо 1 787
  • Сорбифер дурулес таб. п/о, 30 шт.
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    Сорбифер дурулес таб. п/о, 30 шт.

    Цена 701 ₽
  • Фенибут таб., 250 мг, 20 шт.
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    Фенибут таб., 250 мг, 20 шт.

    Цена 110 ₽
  • Тотема р-р д/вн. приема, 20 шт.
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217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFgipvuBsELj+vq35Ahjm7cIQIJz+oxg=","sign":"CUBTAyPb+O1CdBJwWDjSAaBJrT19h59S8xiAXB3jZiM="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228073257_13/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228073257_13/content/content/toggleWishlist":{"skuId":"101295570744","productId":228073257,"offerId":"DgBaQEHfiWVpajpZcbllcw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFgipvuBsELj+vq35Ahjm7cIQIJz+oxg=","sign":"CUBTAyPb+O1CdBJwWDjSAaBJrT19h59S8xiAXB3jZiM="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228073257_13/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тотема р-р д/вн. приема, 20 шт.

    Цена 708 ₽ вместо 897
  • Магне B6 таб. п/о, 100 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1916604871_14/content/content/toggleWishlist":{"skuId":"102292844752","productId":1916604871,"offerId":"cLCpQ-dHDFQPHXwgcuoPVA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFwjHo/SRBxDQ4YOJ/QIYhob7ESCc/qMY","sign":"0PEFz+t9d+Yj9V48c75ge60X7bAgVkBveKH4tMQ4BL8="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1916604871_14/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Магне B6 таб. п/о, 100 шт.

    Цена 797 ₽ вместо 1 206
  • Folate (Metafoline) таб., 400 мкг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:496792176_15/content/content/toggleWishlist":{"skuId":"101313892748","productId":496792176,"offerId":"0i6c07qFJutGJkxM7nt-wg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFgjw5PHsARCMo522+QIY34bpBiCZwwU=","sign":"J4eG3YK+DrNG1KTDrS0soL5Ydl2/jZta/qRig5wgN0A="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:496792176_15/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Folate (Metafoline) таб., 400 мкг, 50 шт.

    Цена 1 237 ₽ вместо 1 508
  • Аквадетрим таб. раств., 2000 ME, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:961269980_16/content/content/gallery":{"title":"Аквадетрим таб. раств., 2000 ME, 60 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5251330/img_id2203294367998007432.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5251330/img_id2203294367998007432.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5251330/img_id2203294367998007432.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5251330/img_id2203294367998007432.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5251330/img_id2203294367998007432.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5251330/img_id2203294367998007432.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5222168/img_id6736152651554858231.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5222168/img_id6736152651554858231.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5222168/img_id6736152651554858231.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5222168/img_id6736152651554858231.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5222168/img_id6736152651554858231.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5222168/img_id6736152651554858231.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5281727/img_id1975532315550966583.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5281727/img_id1975532315550966583.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5281727/img_id1975532315550966583.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5281727/img_id1975532315550966583.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5281727/img_id1975532315550966583.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5281727/img_id1975532315550966583.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4034173/img_id684104393281503337.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4034173/img_id684104393281503337.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4034173/img_id684104393281503337.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4034173/img_id684104393281503337.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4034173/img_id684104393281503337.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4034173/img_id684104393281503337.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4615588/img_id5828027987316976083.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4615588/img_id5828027987316976083.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4615588/img_id5828027987316976083.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4615588/img_id5828027987316976083.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4615588/img_id5828027987316976083.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4615588/img_id5828027987316976083.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4449143/img_id3900053060675956740.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4449143/img_id3900053060675956740.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4449143/img_id3900053060675956740.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4449143/img_id3900053060675956740.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4449143/img_id3900053060675956740.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4449143/img_id3900053060675956740.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFwjcoa/KAxDYpeaJ+gIYntShBSCc/qMY","sign":"/WPe42e7ALTgjMzYewJbATqix/9lBBKhkuQMctXpq/4="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:961269980_16/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:961269980_16/content/content/toggleWishlist":{"skuId":"101489152728","productId":961269980,"offerId":"s_YO1QZqa2fX83fwPHo7Uw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFwjcoa/KAxDYpeaJ+gIYntShBSCc/qMY","sign":"/WPe42e7ALTgjMzYewJbATqix/9lBBKhkuQMctXpq/4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:961269980_16/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Аквадетрим таб. раств., 2000 ME, 60 шт.

    Цена 637 ₽ вместо 729
  • ЛимфоТранзит концентрат напитка фл., 100 мл
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_17/content/content/gallery":{"title":"ЛимфоТранзит концентрат напитка фл., 100 мл","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFgjA+JbRBhCNiZe8AhjVu6EGINfcwQc=","sign":"q582VGP66pn9KT2LSr7V/+Hze8/o9pYcyoyrBeW4qnQ="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_17/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_17/content/content/toggleWishlist":{"skuId":"663078029","productId":1780857920,"offerId":"sfF41jLd_lfJnq7MPes0zw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQlqXi0cSc1qiGARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFgjA+JbRBhCNiZe8AhjVu6EGINfcwQc=","sign":"q582VGP66pn9KT2LSr7V/+Hze8/o9pYcyoyrBeW4qnQ="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_17/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • Феррум лек р-р д/ин., 50 мг/мл, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228091102_18/content/content/gallery":{"title":"Феррум лек р-р д/ин., 50 мг/мл, 5 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4303439/img_id7908319186242125551.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4303439/img_id7908319186242125551.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4303439/img_id7908319186242125551.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4303439/img_id7908319186242125551.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4303439/img_id7908319186242125551.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4303439/img_id7908319186242125551.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 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    Феррум лек р-р д/ин., 50 мг/мл, 5 шт.

    Цена 1 899 ₽
  • Капсулы NOW Biotin, 100 г, 150 мл, 5000 мкг, 60 шт.
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    Капсулы NOW Biotin, 100 г, 150 мл, 5000 мкг, 60 шт.

    Цена 950 ₽ вместо 1 220
  • Хофитол таб. п/о, 60 шт.
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    Хофитол таб. п/о, 60 шт.

    Цена 559 ₽ вместо 565
  • Реклама
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  • Solgar, Omega-3, EPA & DHA, Triple Strength, 950 mg, омега-3, ЭПК и ДГК, тройной концентрации, 950 мг, 50 капсул
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    Solgar, Omega-3, EPA & DHA, Triple Strength, 950 mg, омега-3, ЭПК и ДГК, тройной концентрации, 950 мг, 50 капсул

    Цена 2 495 ₽ вместо 3 275
  • Супрадин таб. п/о, 30 шт.
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    Супрадин таб. п/о, 30 шт.

    Цена 856 ₽ вместо 1 121
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