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Фосфоглив Урсо капс., 35 мг+250 мг, 50 шт.

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4.9
(19)
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Коротко о товаре

Артикул Маркета
4453173126
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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Дети старше 12 лет и взрослые с массой тела более 47 кг капсулу про­глатывают целиком. Препарат необходимо принимать регулярно.\u003Cbr /\u003EДля удобства режимы дозирования для разных показаний представлены в пересчете на урсодезоксихолевую кислоту.\u003Cbr /\u003EНеалкогольный стеатогепатит:\u003Cbr /\u003EСредняя суточная доза 10-15 мг/кг в 2-3 приема. Длительность терапии составляет от 6-12 месяцев и более.\u003Cbr /\u003EАлкогольная болезнь печени:\u003Cbr /\u003EСредняя суточная доза 10-15 мг/кг в 2-3 приема. Длительность терапии составляет от 6-12 месяцев и более.\u003Cbr /\u003EСимптоматическое лечение хронических гепатитов различного генеза:\u003Cbr /\u003EСредняя суточная доза 10-15 мг/кг в 2-3 приёма. Длительность терапии 6-12 месяцев и бо­лее.\u003Cbr /\u003EБилиарный рефлюкс-гастрит:\u003Cbr /\u003EПо 1 капсуле препарата ежедневно вечером перед сном. Курс лечения от 10-14 дней до 6 месяцев, при необходимости - до 2 лет.\u003Cbr /\u003EДискинезия желчевыводящих путей:\u003Cbr /\u003EСредняя суточная доза 10 мг/кг в 2 приема в течение от 2 недель до 2 месяцев. При необхо­димости курс лечения рекомендуется повторить.\u003Cbr /\u003EРастворение холестериновых желчных камней:\u003Cbr /\u003EСредняя суточная доза урсодезоксихолевой кислоты составляет 10 мг/кг в сутки, что соот­ветствует:\u003Cbr /\u003EМасса тела\u003Cbr /\u003E\t\u003Cbr /\u003EКоличество капсул\u003Cbr /\u003EДо 60 кг\u003Cbr /\u003E\t\u003Cbr /\u003E2\u003Cbr /\u003E61 - 80 кг\u003Cbr /\u003E\t\u003Cbr /\u003E3\u003Cbr /\u003E81 - 100 кг\u003Cbr /\u003E\t\u003Cbr /\u003E4\u003Cbr /\u003E\u003E 100 кг\u003Cbr /\u003E\t\u003Cbr /\u003E5\u003Cbr /\u003EПрепарат необходимо принимать в суточной дозе однократно ежедневно вечером, перед сном. Для растворения камней обычно требуется 6-24 месяцев. Если после 12 месяцев ле­чения размер камней не уменьшается, то лечение следует прекратить.\u003Cbr /\u003EЭффективность лечения следует оценивать каждые 6 месяцев при ультразвуковом исследо­вании или рентгенографии. В ходе промежуточного обследования следует оценить, не про­изошло ли обызвествление камней за истекший период. В случае обызвествления камней, лечение следует прекратить.\u003Cbr /\u003EПервичный билиарный цирроз:\u003Cbr /\u003EСуточная доза зависит от массы тела и составляет от 2 до 6 капсул (примерно от 10 до 15 мг урсодезоксихолевой кислоты на 1 кг массы тела).\u003Cbr /\u003EВ первые 3 месяца лечения приём препарата следует разделить на несколько приёмов в те­чение дня. После улучшения печёночных показателей суточную дозу препарата можно при­нимать один раз, вечером. Капсулы следует принимать регулярно, не разжёвывая, запивая небольшим количеством воды.\u003Cbr /\u003EПрименение препарата Фосфоглив УРСО для лечения первичного билиарного цирроза может продолжаться в течение неограниченного времени.\u003Cbr /\u003EУ пациентов с первичным билиарным циррозом в редких случаях клинические симптомы могут ухудшаться в начале лечения, например, может участиться зуд. В этом случае лече­ние следует продолжить, принимая по одной капсуле ежедневно, далее следует постепенно повышать дозировку (увеличивая суточную дозу еженедельно на одну капсулу) до тех пор, пока вновь не будет достигнут рекомендованный режим дозирования.\u003Cbr /\u003EПервичный склерозирующий холангит:\u003Cbr /\u003EСуточная доза 12-15 мг/кг; при необходимости доза может быть увеличена до 20 мг/кг в 2-3 приёма. Длительность терапии составляет от 6 месяцев до нескольких лет.\u003Cbr /\u003E"},{"name":"Побочные действия","value":"Оценка нежелательных явлений основана на следующей классификации:\u003Cbr /\u003EОчень часто (≥1/10), часто (≥1/100 - \u003C1/10), нечасто (≥1/1000 - \u003C1/100), редко (≥1/10000 - \u003C1/1000), очень редко (\u003C1/10000).\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr /\u003Eчасто - неоформленный стул или диарея; очень редко - диспепсия (отрыжка, тошнота, вздутие живота), дискомфорт в животе, острые боли в правой верхней части живота.\u003Cbr /\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr /\u003Eочень редко - кальцинирование желчных камней, декомпенсация цирроза печени (при ле­чении развитых стадий первичного билиарного цирроза), которая исчезает после отмены препарата.\u003Cbr /\u003EСо стороны сердечно-сосудистой системы: очень редко - транзиторное повышение арте­риального давления, периферические отеки.\u003Cbr /\u003EАллергические реакции:\u003Cbr /\u003Eочень редко - крапивница, кожная сыпь, затруднение носового дыхания, конъюнктивит, кашель.\u003Cbr /\u003E"},{"name":"Фармакологическое действие","value":"Комбинированный препарат, гепатопротекторное средство, оказывает также желчегонное, холелитолитическое, антиоксидантное, противовоспалительное действие, влияет на фиброгенез.\u003Cbr /\u003EУрсодезоксихолевая кислота\u003Cbr /\u003EУрсодезоксихолевая кислота оказывает желчегонное действие. Уменьшает синтез холесте­рина в печени, всасывание его в кишечнике и концентрацию в желчи, повышает раствори­мость холестерина в желчевыводящей системе, стимулирует образование и выделение желчи. Снижает литогенность желчи, увеличивает в ней содержание желчных кислот; вы­зывает усиление желудочной и панкреатической секреции, усиливает активность липазы, оказывает гипогликемическое действие. Вызывает частичное или полное растворение хо­лестериновых камней при энтеральном применении, уменьшает насыщенность желчи хо­лестерином, что способствует мобилизации холестерина из желчных камней. Оказывает иммуномодулирующее действие, влияет на иммунологические реакции в печени: умень­шает экспрессию некоторых антигенов на мембране гепатоцитов. влияет на количество Т-лимфоцитов, образование интрлейкина-2, уменьшает количество эозинофилов.\u003Cbr /\u003EГлицирризиновая кислота\u003Cbr /\u003EОказывает гепатопротекторное действие за счет антиоксидантного, противовоспалитель­ного эффектов, а также влияния на фиброгенез.\u003Cbr /\u003EГлицирризиновая кислота связывает свободные кислородные радикалы и ингибирует фер­менты, инициирующие перекисное окисление липидов (ПОЛ) в гепатоцитах. Глицирризиновая кислота уменьшает воспаление за счет ингибирующего влияния на NF-kB- и ТLR4-сигнальные пути; угнетения продукции прововоспалительных цитокинов (ФНО α, ИЛ-1, ИЛ-6, ИЛ-8); стимулирования продукции противовоспалительных цитоки­нов (ИЛ-2, ИЛ-10, ИЛ-12). Глицирризиновая кислота ингибирует 11 β-оксистероиддегидрогеназу, что способствует повышению эндогенного кортизола в крови (псевдокортикостероидный эффект).\u003Cbr /\u003EВлияние на фиброгенез связано с уменьшением экспрессии гена коллагена 1-го типа и сни­жением продукции коллагена звездчатыми клетками печени (клетками Ито), а также разру­шением активированных клеток Ито через систему натуральных киллеров, что способ­ствует замедлению прогрессирования фиброза.\u003Cbr /\u003E"},{"name":"Фармакологическая группа","value":"препараты для лечения печени и желчевыводящих путей в комбинации"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"В случае передозировки урсодезоксихолевой кислоты возможна диарея. В целом, другие симптомы передозировки маловероятны, поскольку с увеличением дозы урсодезоксихоле­вой кислоты ее абсорбция снижается, а выведение с каловыми массами увеличивается. По­следствия диареи лечатся симптоматически (восстановление водно-электролитного ба­ланса).\u003Cbr\u003EСлучаи передозировки глицирризиновой кислоты до настоящего времени не выявлены."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан в период беременности и грудного вскармливания (в связи с не­достаточностью данных о применении у данных групп пациентов)."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат не оказывает негативного влияния на способность управлять транспортными средствами или выполнять другую работу, требующую повышенной концентрации внимания и быстроты психомоторных реакций. Или же это влияние минимальное."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr /\u003E- У больных с портальной гипертензией;\u003Cbr /\u003E- у больных с артериальной гипертензией.\u003Cbr /\u003EПриём препарата должен осуществляться под наблюдением врача.\u003Cbr /\u003EВ течение первых 3 месяцев лечения необходим контроль активности \"печеночных\" трансаминаз, щелочной фосфатазы, гамма-глютамилтранспептидазы, концентрации билиру­бина в сыворотке крови каждые 4 недели, а затем каждые 3 месяца. Контроль указанных параметров позволяет выявить нарушения функции печени на ранних стадиях. Также это касается пациентов на поздних стадиях первичного билиарного цирроза. Кроме того, так можно быстро определить, реагирует ли пациент с первичным билиарным циррозом на про­водимое лечение.\u003Cbr /\u003EПри применении для растворения холестериновых желчных камней\u003Cbr /\u003EДля оценки прогресса в лечении и для своевременного выявления признаков кальциноза камней в зависимости от их размера, желчный пузырь следует визуализировать (перораль­ная холецистография) с осмотром затемнений в положении стоя и лёжа на спине (ультра­звуковое исследование) через 6-10 месяцев после начала лечения.\u003Cbr /\u003EЕсли желчный пузырь невозможно визуализировать на рентгеновских снимках или в случае кальциноза камней, слабой сократимости желчного пузыря или частых приступов колик, препарат применять не следует.\u003Cbr /\u003EПри лечении пациентов на поздних стадиях первичного билиарного цирроза\u003Cbr /\u003EКрайне редко отмечались случаи декомпенсации цирроза печени. После прекращения ле­чения отмечалось регрессия проявлений декомпенсации.\u003Cbr /\u003EУ пациентов с первичным билиарным циррозом в редких случаях в начале лечения воз­можно усиление клинических симптомов, например, может усилиться зуд. В этом случае дозу препарата необходимо снизить до 250 мг (в пересчете на урсодезоксихолевую кис­лоту), а затем постепенно вновь увеличивать, как описано в разделе \"Способ применения и дозы\".\u003Cbr /\u003EПри применении пациентов с первичным склерозирующим холангитом\u003Cbr /\u003EДлительная терапия высокими дозами урсодезоксихолевой кислоты (28-30 мг/кг/сут) у па­циентов с данной патологией может вызвать серьезные побочные явления.\u003Cbr /\u003EУ пациентов с диареей следует уменьшить дозировку препарата. При персистирующей диа­рее следует прекратить лечение.\u003Cbr /\u003EЖенщины детородного возраста могут принимать препарат, только если они используют надежные средства контрацепции. Рекомендуется использовать негормональные противо­зачаточные средства, либо пероральные контрацептивы с низким содержанием эстрогенов, поскольку гормональные пероральные контрацептивы могут усиливать камнеобразование в желчном пузыре. До начала лечения следует исключить возможную беременность.\u003Cbr /\u003EВ случае повышения артериального давления лечение препаратом следует прекратить.\u003Cbr /\u003E"},{"name":"Взаимодействие","value":"Урсодезоксихолевая кислота\u003Cbr /\u003EКолестирамин, колестипол и антациды, содержащие алюминия гидроксид или смектит (алюминия оксид), снижают абсорбцию урсодезоксихолевой кислоты в кишечнике и, таким образом, уменьшают ее поглощение и эффективность. Если же использование препаратов, содержащих хотя бы одно из этих веществ, всё же является необходимым, их нужно при­нимать минимум за 2 часа до приёма препарата Фосфоглив УРСО.\u003Cbr /\u003EПри одновременном применении урсодезоксихолевая кислота может увеличить абсорбцию циклоспорина из кишечника. Поэтому у больных, принимающих циклоспорин, необходимо определять концентрацию циклоспорина в крови и в случае необходимости корректировать дозу циклоспорина.\u003Cbr /\u003EУрсодезоксихолевая кислота может снижать всасывание ципрофлоксацина.\u003Cbr /\u003EПри одновременном применении урсодезоксихолевая кислота может вызывать небольшое повышение уровня розувастатина в плазме крови. Клиническая значимость этого взаимо­действия, в том числе, в отношении других статинов не известна.\u003Cbr /\u003EУрсодезоксихолевая кислота снижает концентрацию и площадь под фармакокинетической кривой \"концентрация-время\" блокатора медленных кальциевых каналов нитрендипина. В случае одновременного применения нитрендипина и урсодезоксихолевой кислоты реко­мендуется тщательный мониторинг. Может потребоваться увеличение дозы нитрендипина. Кроме того, сообщалось о снижении терапевтического эффекта дапсона.\u003Cbr /\u003EЭти сведения, а также данные, полученные in vitro, позволяют предположить, что урсодез­оксихолевая кислота может индуцировать изоферменты CYP3A. Тем не менее, результаты контролируемых клинических исследований свидетельствуют о том, что урсодезоксихоле­вая кислота не оказывает выраженного индуцирующего влияния на изофермент CYP3A. Эстрогены, гиполипидемические лекарственные средства, такие как клофибрат, увеличи­вают насыщение желчи холестерином и могут снижать литолитический эффект урсодез­оксихолевой кислоты.\u003Cbr /\u003EГлицирризиновая кислота\u003Cbr /\u003EСлучаев межлекарственных взаимодействий не описано.\u003Cbr /\u003E"},{"name":"Регистрационный номер","value":"ЛП-005964"},{"name":"Дата государственной регистрации","value":"30.12.2020"},{"name":"Владелец регистрационного удостоверения","value":"Фармстандарт-Лексредства","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:16227855"]}}},{"name":"Изготовитель","value":"Фармстандарт-Лексредства"},{"name":"Фасовщик","value":"Фармстандарт-Лексредства"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Фосфоглив","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18020848"]}}},{"name":"Срок годности","value":"25 мес."}]}},"fullSpecsGrouped":{"8259275363864804072":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"печень"},{"name":"Назначение","value":"алкогольная болезнь печени, билиарный рефлюкс-гастрит, билиарный цирроз печени, дискинезия желчевыводящих путей, растворение холестериновых камней, стеатогепатит, холангит, хронические гепатиты, хронический алкогольный гепатит"},{"name":"Показания к применению","value":"- Неалкогольный стеатогепатит;\u003Cbr /\u003E- алкогольная болезнь печени;\u003Cbr /\u003E- хронические гепатиты различного генеза;\u003Cbr /\u003E- билиарный рефлюкс-гастрит;\u003Cbr /\u003E- дискинезия желчевыводящих путей;\u003Cbr /\u003E- растворение холестериновых камней желчного пузыря;\u003Cbr /\u003E- первичный билиарный цирроз печени при отсутствии признаков декомпенсации;\u003Cbr /\u003E- первичный склерозирующий холангит.\u003Cbr /\u003E"},{"name":"Противопоказания","value":"- Повышенная чувствительность к компонентам препарата или другим желчным кислотам;\u003Cbr /\u003E- рентгенположительные (с высоким содержанием кальция) желчные камни;\u003Cbr /\u003E- нарушение сократительной способности желчного пузыря;\u003Cbr /\u003E- частые эпизоды желчной колики;\u003Cbr /\u003E- окклюзия желчевыводящих путей (окклюзия общего желчного или пузырного протоков);\u003Cbr /\u003E- острые воспалительные заболевания желчного пузыря и желчных протоков;\u003Cbr /\u003E- цирроз печени в стадии декомпенсации;\u003Cbr /\u003E- выраженная печеночная недостаточность и/или почечная недостаточность;\u003Cbr /\u003E- беременность;\u003Cbr /\u003E- период грудного вскармливания;\u003Cbr /\u003E- детский возраст до 12 лет;\u003Cbr /\u003E- взрослые и дети с массой тела до 47 кг (для данной лекарственной формы)\u003Cbr /\u003E- неудачно выполненная портоэнтеростомия или случаи отсутствия восстановления нор­мального тока желчи у детей с атрезией желчевыводящих путей.\u003Cbr /\u003E"},{"name":"Состав","value":"Состав на одну капсулу:\u003Cbr /\u003EДействующие вещества: урсодезоксихолевая кислота - 250,0 мг, натрия глицирризинат в пересчете на 100% вещество (тринатриевая соль глицирризиновой кислоты) - 35,0 мг.\u003Cbr /\u003EВспомогательные вещества: целлюлоза микрокристаллическая М 101 - 30,5 мг, натрия кроскармеллоза - 6,6 мг, гипролоза (гидроксипропилцеллюлоза) - 3,3 мг, магния стеарат - 2,8 мг, кремния диоксид коллоидный (аэросил) - 1,8 мг.\u003Cbr /\u003EСостав оболочки капсулы (корпус и крышечка): титана диоксид (Е 171) - 1,92 мг, желатин - 94,08 мг.\u003Cbr /\u003E"},{"name":"Действующее вещество","value":"Глицирризиновая кислота+Урсодезоксихолевая кислота"},{"name":"Способ применения и дозы","value":"Принимать внутрь. Дети старше 12 лет и взрослые с массой тела более 47 кг капсулу про­глатывают целиком. Препарат необходимо принимать регулярно.\u003Cbr /\u003EДля удобства режимы дозирования для разных показаний представлены в пересчете на урсодезоксихолевую кислоту.\u003Cbr /\u003EНеалкогольный стеатогепатит:\u003Cbr /\u003EСредняя суточная доза 10-15 мг/кг в 2-3 приема. Длительность терапии составляет от 6-12 месяцев и более.\u003Cbr /\u003EАлкогольная болезнь печени:\u003Cbr /\u003EСредняя суточная доза 10-15 мг/кг в 2-3 приема. Длительность терапии составляет от 6-12 месяцев и более.\u003Cbr /\u003EСимптоматическое лечение хронических гепатитов различного генеза:\u003Cbr /\u003EСредняя суточная доза 10-15 мг/кг в 2-3 приёма. Длительность терапии 6-12 месяцев и бо­лее.\u003Cbr /\u003EБилиарный рефлюкс-гастрит:\u003Cbr /\u003EПо 1 капсуле препарата ежедневно вечером перед сном. Курс лечения от 10-14 дней до 6 месяцев, при необходимости - до 2 лет.\u003Cbr /\u003EДискинезия желчевыводящих путей:\u003Cbr /\u003EСредняя суточная доза 10 мг/кг в 2 приема в течение от 2 недель до 2 месяцев. При необхо­димости курс лечения рекомендуется повторить.\u003Cbr /\u003EРастворение холестериновых желчных камней:\u003Cbr /\u003EСредняя суточная доза урсодезоксихолевой кислоты составляет 10 мг/кг в сутки, что соот­ветствует:\u003Cbr /\u003EМасса тела\u003Cbr /\u003E\t\u003Cbr /\u003EКоличество капсул\u003Cbr /\u003EДо 60 кг\u003Cbr /\u003E\t\u003Cbr /\u003E2\u003Cbr /\u003E61 - 80 кг\u003Cbr /\u003E\t\u003Cbr /\u003E3\u003Cbr /\u003E81 - 100 кг\u003Cbr /\u003E\t\u003Cbr /\u003E4\u003Cbr /\u003E\u003E 100 кг\u003Cbr /\u003E\t\u003Cbr /\u003E5\u003Cbr /\u003EПрепарат необходимо принимать в суточной дозе однократно ежедневно вечером, перед сном. Для растворения камней обычно требуется 6-24 месяцев. Если после 12 месяцев ле­чения размер камней не уменьшается, то лечение следует прекратить.\u003Cbr /\u003EЭффективность лечения следует оценивать каждые 6 месяцев при ультразвуковом исследо­вании или рентгенографии. В ходе промежуточного обследования следует оценить, не про­изошло ли обызвествление камней за истекший период. В случае обызвествления камней, лечение следует прекратить.\u003Cbr /\u003EПервичный билиарный цирроз:\u003Cbr /\u003EСуточная доза зависит от массы тела и составляет от 2 до 6 капсул (примерно от 10 до 15 мг урсодезоксихолевой кислоты на 1 кг массы тела).\u003Cbr /\u003EВ первые 3 месяца лечения приём препарата следует разделить на несколько приёмов в те­чение дня. После улучшения печёночных показателей суточную дозу препарата можно при­нимать один раз, вечером. Капсулы следует принимать регулярно, не разжёвывая, запивая небольшим количеством воды.\u003Cbr /\u003EПрименение препарата Фосфоглив УРСО для лечения первичного билиарного цирроза может продолжаться в течение неограниченного времени.\u003Cbr /\u003EУ пациентов с первичным билиарным циррозом в редких случаях клинические симптомы могут ухудшаться в начале лечения, например, может участиться зуд. В этом случае лече­ние следует продолжить, принимая по одной капсуле ежедневно, далее следует постепенно повышать дозировку (увеличивая суточную дозу еженедельно на одну капсулу) до тех пор, пока вновь не будет достигнут рекомендованный режим дозирования.\u003Cbr /\u003EПервичный склерозирующий холангит:\u003Cbr /\u003EСуточная доза 12-15 мг/кг; при необходимости доза может быть увеличена до 20 мг/кг в 2-3 приёма. Длительность терапии составляет от 6 месяцев до нескольких лет.\u003Cbr /\u003E"},{"name":"Побочные действия","value":"Оценка нежелательных явлений основана на следующей классификации:\u003Cbr /\u003EОчень часто (≥1/10), часто (≥1/100 - \u003C1/10), нечасто (≥1/1000 - \u003C1/100), редко (≥1/10000 - \u003C1/1000), очень редко (\u003C1/10000).\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr /\u003Eчасто - неоформленный стул или диарея; очень редко - диспепсия (отрыжка, тошнота, вздутие живота), дискомфорт в животе, острые боли в правой верхней части живота.\u003Cbr /\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr /\u003Eочень редко - кальцинирование желчных камней, декомпенсация цирроза печени (при ле­чении развитых стадий первичного билиарного цирроза), которая исчезает после отмены препарата.\u003Cbr /\u003EСо стороны сердечно-сосудистой системы: очень редко - транзиторное повышение арте­риального давления, периферические отеки.\u003Cbr /\u003EАллергические реакции:\u003Cbr /\u003Eочень редко - крапивница, кожная сыпь, затруднение носового дыхания, конъюнктивит, кашель.\u003Cbr /\u003E"},{"name":"Фармакологическое действие","value":"Комбинированный препарат, гепатопротекторное средство, оказывает также желчегонное, холелитолитическое, антиоксидантное, противовоспалительное действие, влияет на фиброгенез.\u003Cbr /\u003EУрсодезоксихолевая кислота\u003Cbr /\u003EУрсодезоксихолевая кислота оказывает желчегонное действие. Уменьшает синтез холесте­рина в печени, всасывание его в кишечнике и концентрацию в желчи, повышает раствори­мость холестерина в желчевыводящей системе, стимулирует образование и выделение желчи. Снижает литогенность желчи, увеличивает в ней содержание желчных кислот; вы­зывает усиление желудочной и панкреатической секреции, усиливает активность липазы, оказывает гипогликемическое действие. Вызывает частичное или полное растворение хо­лестериновых камней при энтеральном применении, уменьшает насыщенность желчи хо­лестерином, что способствует мобилизации холестерина из желчных камней. Оказывает иммуномодулирующее действие, влияет на иммунологические реакции в печени: умень­шает экспрессию некоторых антигенов на мембране гепатоцитов. влияет на количество Т-лимфоцитов, образование интрлейкина-2, уменьшает количество эозинофилов.\u003Cbr /\u003EГлицирризиновая кислота\u003Cbr /\u003EОказывает гепатопротекторное действие за счет антиоксидантного, противовоспалитель­ного эффектов, а также влияния на фиброгенез.\u003Cbr /\u003EГлицирризиновая кислота связывает свободные кислородные радикалы и ингибирует фер­менты, инициирующие перекисное окисление липидов (ПОЛ) в гепатоцитах. Глицирризиновая кислота уменьшает воспаление за счет ингибирующего влияния на NF-kB- и ТLR4-сигнальные пути; угнетения продукции прововоспалительных цитокинов (ФНО α, ИЛ-1, ИЛ-6, ИЛ-8); стимулирования продукции противовоспалительных цитоки­нов (ИЛ-2, ИЛ-10, ИЛ-12). Глицирризиновая кислота ингибирует 11 β-оксистероиддегидрогеназу, что способствует повышению эндогенного кортизола в крови (псевдокортикостероидный эффект).\u003Cbr /\u003EВлияние на фиброгенез связано с уменьшением экспрессии гена коллагена 1-го типа и сни­жением продукции коллагена звездчатыми клетками печени (клетками Ито), а также разру­шением активированных клеток Ито через систему натуральных киллеров, что способ­ствует замедлению прогрессирования фиброза.\u003Cbr /\u003E"},{"name":"Фармакологическая группа","value":"препараты для лечения печени и желчевыводящих путей в комбинации"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"В случае передозировки урсодезоксихолевой кислоты возможна диарея. В целом, другие симптомы передозировки маловероятны, поскольку с увеличением дозы урсодезоксихоле­вой кислоты ее абсорбция снижается, а выведение с каловыми массами увеличивается. По­следствия диареи лечатся симптоматически (восстановление водно-электролитного ба­ланса).\u003Cbr\u003EСлучаи передозировки глицирризиновой кислоты до настоящего времени не выявлены."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан в период беременности и грудного вскармливания (в связи с не­достаточностью данных о применении у данных групп пациентов)."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат не оказывает негативного влияния на способность управлять транспортными средствами или выполнять другую работу, требующую повышенной концентрации внимания и быстроты психомоторных реакций. Или же это влияние минимальное."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr /\u003E- У больных с портальной гипертензией;\u003Cbr /\u003E- у больных с артериальной гипертензией.\u003Cbr /\u003EПриём препарата должен осуществляться под наблюдением врача.\u003Cbr /\u003EВ течение первых 3 месяцев лечения необходим контроль активности \"печеночных\" трансаминаз, щелочной фосфатазы, гамма-глютамилтранспептидазы, концентрации билиру­бина в сыворотке крови каждые 4 недели, а затем каждые 3 месяца. Контроль указанных параметров позволяет выявить нарушения функции печени на ранних стадиях. Также это касается пациентов на поздних стадиях первичного билиарного цирроза. Кроме того, так можно быстро определить, реагирует ли пациент с первичным билиарным циррозом на про­водимое лечение.\u003Cbr /\u003EПри применении для растворения холестериновых желчных камней\u003Cbr /\u003EДля оценки прогресса в лечении и для своевременного выявления признаков кальциноза камней в зависимости от их размера, желчный пузырь следует визуализировать (перораль­ная холецистография) с осмотром затемнений в положении стоя и лёжа на спине (ультра­звуковое исследование) через 6-10 месяцев после начала лечения.\u003Cbr /\u003EЕсли желчный пузырь невозможно визуализировать на рентгеновских снимках или в случае кальциноза камней, слабой сократимости желчного пузыря или частых приступов колик, препарат применять не следует.\u003Cbr /\u003EПри лечении пациентов на поздних стадиях первичного билиарного цирроза\u003Cbr /\u003EКрайне редко отмечались случаи декомпенсации цирроза печени. После прекращения ле­чения отмечалось регрессия проявлений декомпенсации.\u003Cbr /\u003EУ пациентов с первичным билиарным циррозом в редких случаях в начале лечения воз­можно усиление клинических симптомов, например, может усилиться зуд. В этом случае дозу препарата необходимо снизить до 250 мг (в пересчете на урсодезоксихолевую кис­лоту), а затем постепенно вновь увеличивать, как описано в разделе \"Способ применения и дозы\".\u003Cbr /\u003EПри применении пациентов с первичным склерозирующим холангитом\u003Cbr /\u003EДлительная терапия высокими дозами урсодезоксихолевой кислоты (28-30 мг/кг/сут) у па­циентов с данной патологией может вызвать серьезные побочные явления.\u003Cbr /\u003EУ пациентов с диареей следует уменьшить дозировку препарата. При персистирующей диа­рее следует прекратить лечение.\u003Cbr /\u003EЖенщины детородного возраста могут принимать препарат, только если они используют надежные средства контрацепции. Рекомендуется использовать негормональные противо­зачаточные средства, либо пероральные контрацептивы с низким содержанием эстрогенов, поскольку гормональные пероральные контрацептивы могут усиливать камнеобразование в желчном пузыре. До начала лечения следует исключить возможную беременность.\u003Cbr /\u003EВ случае повышения артериального давления лечение препаратом следует прекратить.\u003Cbr /\u003E"},{"name":"Взаимодействие","value":"Урсодезоксихолевая кислота\u003Cbr /\u003EКолестирамин, колестипол и антациды, содержащие алюминия гидроксид или смектит (алюминия оксид), снижают абсорбцию урсодезоксихолевой кислоты в кишечнике и, таким образом, уменьшают ее поглощение и эффективность. Если же использование препаратов, содержащих хотя бы одно из этих веществ, всё же является необходимым, их нужно при­нимать минимум за 2 часа до приёма препарата Фосфоглив УРСО.\u003Cbr /\u003EПри одновременном применении урсодезоксихолевая кислота может увеличить абсорбцию циклоспорина из кишечника. Поэтому у больных, принимающих циклоспорин, необходимо определять концентрацию циклоспорина в крови и в случае необходимости корректировать дозу циклоспорина.\u003Cbr /\u003EУрсодезоксихолевая кислота может снижать всасывание ципрофлоксацина.\u003Cbr /\u003EПри одновременном применении урсодезоксихолевая кислота может вызывать небольшое повышение уровня розувастатина в плазме крови. Клиническая значимость этого взаимо­действия, в том числе, в отношении других статинов не известна.\u003Cbr /\u003EУрсодезоксихолевая кислота снижает концентрацию и площадь под фармакокинетической кривой \"концентрация-время\" блокатора медленных кальциевых каналов нитрендипина. В случае одновременного применения нитрендипина и урсодезоксихолевой кислоты реко­мендуется тщательный мониторинг. Может потребоваться увеличение дозы нитрендипина. Кроме того, сообщалось о снижении терапевтического эффекта дапсона.\u003Cbr /\u003EЭти сведения, а также данные, полученные in vitro, позволяют предположить, что урсодез­оксихолевая кислота может индуцировать изоферменты CYP3A. Тем не менее, результаты контролируемых клинических исследований свидетельствуют о том, что урсодезоксихоле­вая кислота не оказывает выраженного индуцирующего влияния на изофермент CYP3A. Эстрогены, гиполипидемические лекарственные средства, такие как клофибрат, увеличи­вают насыщение желчи холестерином и могут снижать литолитический эффект урсодез­оксихолевой кислоты.\u003Cbr /\u003EГлицирризиновая кислота\u003Cbr /\u003EСлучаев межлекарственных взаимодействий не описано.\u003Cbr /\u003E"},{"name":"Регистрационный номер","value":"ЛП-005964"},{"name":"Дата государственной регистрации","value":"30.12.2020"},{"name":"Владелец регистрационного удостоверения","value":"Фармстандарт-Лексредства"},{"name":"Изготовитель","value":"Фармстандарт-Лексредства"},{"name":"Фасовщик","value":"Фармстандарт-Лексредства"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Фосфоглив"},{"name":"Срок годности","value":"25 мес."}]}],"transitionId":"tr_17672144068775947851"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена с картой Яндекс Пэй 886 ₽ вместо 895
    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  • Эссенциальные фосфолипиды Макси формула капс., 1.4 г, 60 шт., 1 уп.
    ВАМ–44 %
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    Эссенциальные фосфолипиды Макси формула капс., 1.4 г, 60 шт., 1 уп.

    Рейтинг товара: 4.4 из 5
    на основе 86 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 465 ₽ вместо 475
    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фосфолипиды Макси формула капс., 1.4 г, 60 шт., 1 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  • Овесол таб. п/о, 40 шт.
    –2 %
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    Овесол таб. п/о, 40 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 544 ₽ вместо 556
    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таб. п/о, 40 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  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
    –22 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mvwemvv2it/toggleWishlist":{"skuId":"227830270","productId":1778171037,"offerId":"pQcXMJSrQ6Doa9yziMm5Vg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQkrrfrqygl6eFARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIVCJ358s8GEP7T0WwY1buhBiDa2cEH","sign":"/YS9qwWGO0Lusuvfd5kIHipr0VFHoHwm+oiJKO05fKU="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mvwemvv2it/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Рейтинг товара: 4.5 из 5
    на основе 1291 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 812 ₽ вместо 820
    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фактор таб. п/о, 1.2 г, 60 шт., 1 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  • Гепакомб Эссенциальные фосфолипиды капс., 0.43 г, 60 шт., 1 уп.
    ВАМ–6 %
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    Гепакомб Эссенциальные фосфолипиды капс., 0.43 г, 60 шт., 1 уп.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 376 ₽ вместо 380
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Эссенциальные фосфолипиды капс., 0.43 г, 60 шт., 1 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  • Гепатамин таб., 40 шт., 3 уп.
    –17 %
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    Гепатамин таб., 40 шт., 3 уп.

    Рейтинг товара: 4.8 из 5
    на основе 5 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 493 ₽ вместо 2 518
    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  • Эссенциальные фосфолипиды капс., 60 шт.
    –1 %
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    Эссенциальные фосфолипиды капс., 60 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 687 ₽ вместо 694
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  • Фосфосил капс., 30 шт.
    –23 %
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    Фосфосил капс., 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 954 ₽ вместо 974
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  • Лактазар для детей капс., 50 шт., 1 уп.
    –1 %
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    Лактазар для детей капс., 50 шт., 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 77 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 692 ₽ вместо 699
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  • Гепакомб Овелюкс капс., 30 шт.
    –1 %
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    Гепакомб Овелюкс капс., 30 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 248 ₽ вместо 250
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  • ГепаЛанк капс., 0.6 г, 50 шт.
    –28 %
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    ГепаЛанк капс., 0.6 г, 50 шт.

    С картой  Пэй
    Цена с картой Яндекс Пэй 3 960 ₽ вместо 4 000
    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Инструкция

Показания к применению

- Неалкогольный стеатогепатит;
- алкогольная болезнь печени;
- хронические гепатиты различного генеза;
- билиарный рефлюкс-гастрит;
- дискинезия желчевыводящих путей;
- растворение холестериновых камней желчного пузыря;
- первичный билиарный цирроз печени при отсутствии признаков декомпенсации;
- первичный склерозирующий холангит.

Противопоказания

- Повышенная чувствительность к компонентам препарата или другим желчным кислотам;
- рентгенположительные (с высоким содержанием кальция) желчные камни;
- нарушение сократительной способности желчного пузыря;
- частые эпизоды желчной колики;
- окклюзия желчевыводящих путей (окклюзия общего желчного или пузырного протоков);
- острые воспалительные заболевания желчного пузыря и желчных протоков;
- цирроз печени в стадии декомпенсации;
- выраженная печеночная недостаточность и/или почечная недостаточность;
- беременность;
- период грудного вскармливания;
- детский возраст до 12 лет;
- взрослые и дети с массой тела до 47 кг (для данной лекарственной формы)
- неудачно выполненная портоэнтеростомия или случаи отсутствия восстановления нор­мального тока желчи у детей с атрезией желчевыводящих путей.

Способ применения и дозы

Принимать внутрь. Дети старше 12 лет и взрослые с массой тела более 47 кг капсулу про­глатывают целиком. Препарат необходимо принимать регулярно.
Для удобства режимы дозирования для разных показаний представлены в пересчете на урсодезоксихолевую кислоту.
Неалкогольный стеатогепатит:
Средняя суточная доза 10-15 мг/кг в 2-3 приема. Длительность терапии составляет от 6-12 месяцев и более.
Алкогольная болезнь печени:
Средняя суточная доза 10-15 мг/кг в 2-3 приема. Длительность терапии составляет от 6-12 месяцев и более.
Симптоматическое лечение хронических гепатитов различного генеза:
Средняя суточная доза 10-15 мг/кг в 2-3 приёма. Длительность терапии 6-12 месяцев и бо­лее.
Билиарный рефлюкс-гастрит:
По 1 капсуле препарата ежедневно вечером перед сном. Курс лечения от 10-14 дней до 6 месяцев, при необходимости - до 2 лет.
Дискинезия желчевыводящих путей:
Средняя суточная доза 10 мг/кг в 2 приема в течение от 2 недель до 2 месяцев. При необхо­димости курс лечения рекомендуется повторить.
Растворение холестериновых желчных камней:
Средняя суточная доза урсодезоксихолевой кислоты составляет 10 мг/кг в сутки, что соот­ветствует:
Масса тела

Количество капсул
До 60 кг

2
61 - 80 кг

3
81 - 100 кг

4
> 100 кг

5
Препарат необходимо принимать в суточной дозе однократно ежедневно вечером, перед сном. Для растворения камней обычно требуется 6-24 месяцев. Если после 12 месяцев ле­чения размер камней не уменьшается, то лечение следует прекратить.
Эффективность лечения следует оценивать каждые 6 месяцев при ультразвуковом исследо­вании или рентгенографии. В ходе промежуточного обследования следует оценить, не про­изошло ли обызвествление камней за истекший период. В случае обызвествления камней, лечение следует прекратить.
Первичный билиарный цирроз:
Суточная доза зависит от массы тела и составляет от 2 до 6 капсул (примерно от 10 до 15 мг урсодезоксихолевой кислоты на 1 кг массы тела).
В первые 3 месяца лечения приём препарата следует разделить на несколько приёмов в те­чение дня. После улучшения печёночных показателей суточную дозу препарата можно при­нимать один раз, вечером. Капсулы следует принимать регулярно, не разжёвывая, запивая небольшим количеством воды.
Применение препарата Фосфоглив УРСО для лечения первичного билиарного цирроза может продолжаться в течение неограниченного времени.
У пациентов с первичным билиарным циррозом в редких случаях клинические симптомы могут ухудшаться в начале лечения, например, может участиться зуд. В этом случае лече­ние следует продолжить, принимая по одной капсуле ежедневно, далее следует постепенно повышать дозировку (увеличивая суточную дозу еженедельно на одну капсулу) до тех пор, пока вновь не будет достигнут рекомендованный режим дозирования.
Первичный склерозирующий холангит:
Суточная доза 12-15 мг/кг; при необходимости доза может быть увеличена до 20 мг/кг в 2-3 приёма. Длительность терапии составляет от 6 месяцев до нескольких лет.
Полная инструкция
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Фосфоглив Урсо капс.
Фосфоглив Урсо капс., 35 мг+250 мг, 50 шт.
4.9
(19)
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2 вопроса
Инструкция

1 005 ₽

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4.9
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У продавца:19 оценок·4 отзыва
У всех продавцов:120 оценок·30 отзывов
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user avatar
9 месяцев назад • Михаил • Куплен на Маркете
Достоинства: Рабочий препарат. Закрывает вопросы по желчному пузырю и печени сразу
Недостатки: Не замечено, все работает
Комментарий: Принимал раньше и урсосан, и фосфоглив. Теперь нашел вот такое средство, где содержатся оба компонента. Все работает
user avatar
Месяц назад • Денис К • Куплен на Маркете
Достоинства: хороший препарат, за свои деньги !
Недостатки: нету
Комментарий: советую
user avatar
5 месяцев назад • игорь черненко • Куплен на Маркете
Комментарий: Необходимость
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    Гилан ультра комфорт увлажн. гл. р-р, 0.3%, 0.4 мл, 50 г, 10 шт.

    Цена 288 ₽ вместо 331
  • Гепатрин капс., 120 шт.
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    Гепатрин капс., 120 шт.

    Цена 886 ₽ вместо 1 000
  • Вата стерильная хирургическая 100 г
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    Вата стерильная хирургическая 100 г

    Цена 173 ₽ вместо 198
  • Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов
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    Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов

    Цена 194 ₽ вместо 224
  • Эссенциальные фосфолипиды Макси формула капс., 1.4 г, 60 шт., 1 уп.
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    Эссенциальные фосфолипиды Макси формула капс., 1.4 г, 60 шт., 1 уп.

    Цена 465 ₽ вместо 824
  • Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.
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    Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.

    Цена 411 ₽ вместо 443
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    Реклама
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  • Овесол таб. п/о, 40 шт.
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    Овесол таб. п/о, 40 шт.

    Цена 477 ₽ вместо 482
  • Гепакомб Эссенциальные фосфолипиды капс., 0.43 г, 60 шт., 1 уп.
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    Гепакомб Эссенциальные фосфолипиды капс., 0.43 г, 60 шт., 1 уп.

    Цена 376 ₽ вместо 400
  • Кетоконазол шампунь лекарственный, 2%, 75 г, 75 мл
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    Кетоконазол шампунь лекарственный, 2%, 75 г, 75 мл

    Цена 296 ₽ вместо 299
  • Гилан Комфорт увлажн. гл. р-р, 0.18%, 0.4 мл, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1417729452_12/content/content/gallery":{"title":"Гилан Комфорт увлажн. гл. р-р, 0.18%, 0.4 мл, 30 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4932805/img_id8148706369646761136.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4932805/img_id8148706369646761136.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4932805/img_id8148706369646761136.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4932805/img_id8148706369646761136.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4932805/img_id8148706369646761136.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4932805/img_id8148706369646761136.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/11382628/img_id597855710443907940.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/11382628/img_id597855710443907940.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/11382628/img_id597855710443907940.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/11382628/img_id597855710443907940.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/11382628/img_id597855710443907940.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/11382628/img_id597855710443907940.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQkrrfrqygl6eFARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFgisq4OkBRCvu5jbARiH3tAHINzcwQc=","sign":"TkWx2XrupK5VuxNj9VSS4hTpvn1C+hScG/HtLTjO2Bg="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1417729452_12/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Гилан Комфорт увлажн. гл. р-р, 0.18%, 0.4 мл, 30 шт.

    Цена 396 ₽
  • Эссенциальные фосфолипиды капс., 60 шт.
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    Эссенциальные фосфолипиды капс., 60 шт.

    Цена 687 ₽ вместо 694
  • Гепатамин таб., 10 мг, 40 шт., 1 уп.
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    Гепатамин таб., 10 мг, 40 шт., 1 уп.

    Цена 675 ₽ вместо 682
  • IKENA Нафтифин р-р противогрибковый фл., 1%, 37 г, 10 мл, 1 шт., нейтральный, 1 уп.
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    IKENA Нафтифин р-р противогрибковый фл., 1%, 37 г, 10 мл, 1 шт., нейтральный, 1 уп.

    Цена 399 ₽ вместо 480
  • Холисал стомат. гель, 15 г
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1436725414_16/content/content/toggleWishlist":{"skuId":"186571679","productId":1436725414,"offerId":"i94Yw8LXzrxrnvWBloMPfQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQkrrfrqygl6eFARIaChhyZW1peF9kZXNrdG9wX21vZGVsX2NhcmQyFQim4YqtBRCft/tYGLKS2BEgrdrBBw==","sign":"PkHuiCDmOtIzmJa8o19bivGPOyKFjboAucI8mVSRgTw="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1436725414_16/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Холисал стомат. гель, 15 г

    Цена 533 ₽ вместо 538
  • Кленбутерол Софарма таб., 0.02 мг, 50 шт.
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    Кленбутерол Софарма таб., 0.02 мг, 50 шт.

    Цена 686 ₽
  • Симбикорт турбухалер пор. д/инг. дозир., 80 мкг+4.5 мкг/доза, 60 шт.
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    Симбикорт турбухалер пор. д/инг. дозир., 80 мкг+4.5 мкг/доза, 60 шт.

    Цена 1 114 ₽
  • Ревмафлекс капс., 60 шт., нейтральный, 1 уп.
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    Ревмафлекс капс., 60 шт., нейтральный, 1 уп.

    Цена 772 ₽ вместо 950
  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
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    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Цена 812 ₽ вместо 1 039
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    Реклама
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  • Фенибут таб., 250 мг, 10 шт.
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    Фенибут таб., 250 мг, 10 шт.

    Цена 92 ₽
  • Асепта адгезивный бальзам д/десен, 10 мл, 10 г, 1 шт., 1 уп.
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    Асепта адгезивный бальзам д/десен, 10 мл, 10 г, 1 шт., 1 уп.

    Цена 361 ₽ вместо 430
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