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Описание

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Ирунин капс., 100 мг, 14 шт.

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4.4
(11)
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Количество штук в упаковке, шт.

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Коротко о товаре

Артикул Маркета
2265140230
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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отрубевидный лишай-200 мг 1 раз/сут 7 дней; дерматомикозы гладкой кожи-200 мг 1 раз/сут 7 дней или 100 мг 1 раз/сут 15 дней; грибковый кератит-200 мг 1 раз/сут 21 день; поражения высококератинизированных областей, таких как кисти рук и стоп, требуют дополнительного лечения в течение 15 дней в дозе 100 мг/сут; оральный кандидоз-100 мг 1 раз/сут 15 дней.\u003Cbr\u003EТерапии при онихомикозах: по 200 мг (2 капс.) 2 раза/сут в течение 1 недели потом 3 недели интервал между курсами. При поражении ногтевых пластинок стоп с или бес поражения ногтевых пластинок кистей — 3 курса лечения. При поражении только ногтевых пластинок кистей — 2 курса лечения.\u003Cbr\u003EПри онихомикозах возможно применение непрерывной терапии: по 200 мг (2 капс.) 1 раз/сут в течение 3 месяцев. Выведение итраконазола из кожи и ногтевой пластинки осуществляется медленнее, чем из плазмы. Таким образом, оптимальные клинические и микологические эффекты достигаются через 2-4 нед. после окончания лечения при инфекциях кожи и через 6-9 мес после окончания лечения ногтевых инфекций.\u003Cbr\u003EРекомендуемые дозы при системных микозах в зависимости от вида инфекции: аспергиллез-200 мг 1 раз/сут 2-5 мес (увеличить дозу до 200 мг 2 раза/сут в случае инвазивных или диссеминированных форм); кандидоз-100-200 мг 1 раз/сут от 3 нед до 7 мес (увеличить дозу до 200 мг 2 раза/сут в случае инвазивных или диссеминированных форм); криптококкоз (кроме менингита)-200 мг 1 раз/сут от 2 мес до 1 года; криптококковый менингит-200 мг 2 раза/сут от 2 мес до 1 года; гистоплазмоз-200 мг 1 раз/сут-2 раза/сут 8 мес; споротрихоз-100 мг 1 раз/сут 3 месяцев; паракокцидиомикоз-100 мг 1 раз/сут 6мес; хромомикоз-100-200 мг 1 раз/сут 6мес; бластомикоз-от 100 мг 1 раз/сут до 200 мг 2 раза/сут 6 мес."},{"name":"Побочные действия","value":"Со стороны ЖКТ: диспепсия, тошнота, боль в животе и запор. Анорексия, головная боль, утомляемость, обратимое повышение активности печеночных ферментов, холестатическая желтуха, гепатит, нарушения менструального цикла, головокружение и аллергические реакции (такие как зуд, сыпь, крапивница и ангионевротический отек), периферическая нейропатия, синдром Стивенса-Джонсона, алопеция, гипокалиемия, отеки, застойная сердечная недостаточность и отек легких, окрашивание мочи в темный цвет, гиперкреатининемия.\u003Cbr\u003EВ очень редких случаях развивалось тяжелое токсическое поражение печени, в т.ч. случаи острой печеночной недостаточности с летальным исходом."},{"name":"Фармакологическое действие","value":"Противогрибковое широкого спектра.\u003Cbr\u003EПодавляет синтез эргостерола клеточной мембраны грибов. Активен в отношении дерматофитов (Trichophyton spp., Microsporum spp., Epidermophyton floccosum), дрожжевых грибов Candida spp. (включая Candida albicans, Candida parapsilosis), плесневых грибов (Cryptococcus neoformans, Aspergillus spp., Trichosporon spp., Geotrichum spp., Penicillium marneffei, Pseudallescheria boydii, Histoplasma spp., Coccidioides immitis, Paracoccidioides braziliensis, Sporothrix schenckii, Fonsecaea spp., Cladosporium spp., Blastomyces dermatidis), Malassezia spp.\u003Cbr\u003EНекоторые штаммы могут быть устойчивы: Candida glabrata, Candida krusei, Candida tropicalis, Absidia spp., Fusarium spp., Mucor spp., Rhizomucor spp., Rhizopus spp., Scedosporium proliferans, Scopulariopsis spp.\u003Cbr\u003EЭффективность лечения оценивается через 2-4 нед после прекращения терапии (при микозах), через 6-9 мес - при онихомикозах (по мере смены ногтей)."},{"name":"Фармакологическая группа","value":"противогрибковые средства"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Данные отсутствуют. В течение первого часа провести промывание желудка и, если это необходимо, назначить активированный уголь, симптоматическое лечение. Итраконазол не выводится при гемодиализе. Какого-либо специфического антидота не существует."},{"name":"Применение при беременности и кормлении грудью","value":"Беременным женщинам Ирунин следует назначать только в том случае, если ожидаемая польза для женщины превышает потенциальный риск для плода. Так как небольшое количество итраконазола выделяется с материнским молоком, в период лечения необходимо отказаться от грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не наблюдалось."},{"name":"Особые указания","value":"Итраконазол обладает отрицательным инотропным эффектом. Поэтому препарат не следует назначать пациентам с хронической сердечной недостаточностью (в т.ч. в анамнезе) за исключением случаев, когда ожидаемая польза терапии значительно превосходит потенциальный риск. При этом следует принимать во внимание такие факторы, как серьезность показаний, режим дозирования и индивидуальные факторы риска развития хронической сердечной недостаточности (в т.ч. наличие ИБС, поражений клапанов сердца, ХОБЛ, почечной недостаточности).\u003Cbr\u003EПри пониженной кислотности желудка абсорбция итраконазола нарушается. Пациентам, получающим антацидные препараты (например, алюминия гидроксид), рекомендуется принимать их не ранее чем через 2 ч после приема препарата. Пациентам с ахлоргидрией или применяющим блокаторы гистаминовых Н2-рецепторов или ингибиторы протонового насоса рекомендуется принимать капсулы, запивая колой.\u003Cbr\u003EВ очень редких случаях при применении итраконазола развивалось тяжелое токсическое поражение печени, в т.ч. случаи острой печеночной недостаточности с летальным исходом. В большинстве случаев это наблюдалось у пациентов, у которых уже имелись заболевания печени, а также у пациентов, получавших другие лекарственные средства, обладающие гепатотоксическим действием. В связи с этим рекомендуется регулярно контролировать функцию печени у пациентов, получающих терапию итраконазолом.\u003Cbr\u003EВ случае появления симптомов, предполагающих развитие гепатита, в т.ч. анорексии, тошноты, рвоты, слабости, болей в животе и потемнения мочи, необходимо немедленно прекратить прием препарата и провести исследование функции печени. Пациентам с повышенным уровнем печеночных ферментов или заболеванием печени в активной фазе не следует назначать лечение препаратом за исключением тех случаев, когда ожидаемая польза оправдывает риск поражения печени. В этих случаях необходимо во время лечения контролировать уровень печеночных ферментов.\u003Cbr\u003EВ случае развития невропатии, которая может быть вызвана пероральным приемом итраконазола, лечение следует прекратить.\u003Cbr\u003EНет данных о перекрестной гиперчувствительности к итраконазолу и другим противогрибковым препаратам - производным азола. Препарат в капсулах следует назначать с осторожностью пациентам с гиперчувствительностью к другим азолам.\u003Cbr\u003EС осторожностью: детский возраст; тяжелая сердечная недостаточность; заболевания печени (в том числе сопровождающиеся печеночной недостаточностью)."},{"name":"Взаимодействие","value":"Одновременное применение с индукторами микросомальных ферментов печени. Не рекомендуется одновременное применение с рифампицином, рифабутином и фенитоином , которые являются сильными индукторами микросомальных ферментов печени, т.к. эти препараты могут значительно снижать биодоступность итраконазола и гидроксиитраконазола, что приводит к существенному уменьшению эффективности препарата. Исследования по взаимодействию итраконазола с другими индукторами печеночных ферментов, такими как карбамазепин, фенобарбитал и изониазид, не проводились, однако можно предположить развитие аналогичного эффекта.\u003Cbr\u003EОдновременное применение с ингибитирами цитохрома P450.\u003Cbr\u003EТак как итраконазол в основном метаболизируется при участии изофермента CYP3A4 системы цитохрома P450, сильные ингибиторы этого фермента (в том числе ритонавир, индинавир, кларитромицин и эритромицин) могут увеличивать биодоступность итраконазола.\u003Cbr\u003EИтраконазол может ингибировать метаболизм препаратов, которые биотрансформируются при участии изофермента CYP3A4. Результатом этого может быть усиление или пролонгирование их действия, в том числе и побочных эффектов. После прекращения лечения концентрации итраконазола в плазме снижаются постепенно, в зависимости от дозы и длительности лечения.\u003Cbr\u003EОдновременно с итраконазолом нельзя назначать терфенадин, астемизол, мизоластин, цизаприд, триазолам, мидазолам (внутрь), дофетилид, хинидин, пимозид, метаболизирующиеся изоферментом CYP3A4, ингибиторы ГМГ-КоА-редуктазы (симвастатин и ловастатин).\u003Cbr\u003EОдновременное применение с блокаторами кальциевых каналов. Блокаторы кальциевых каналов обладают отрицательным инотропным эффектом, который может усиливать подобный эффект итраконазола; итраконазол может снижать метаболизм блокаторов кальциевых каналов. Следует с осторожностью применять итраконазол одновременно с блокаторами кальциевых каналов.\u003Cbr\u003EПрепараты, при применении которых требуется контроль концентраций в плазме крови: пероральные антикоагулянты; ингибиторы ВИЧ-протеазы (ритонавир, индинавир, саквинавир); некоторые противоопухолевые препараты (алкалоиды барвинка розового, бусульфан, доцетаксел, триметрексат); блокаторы кальциевых каналов, метаболизирующиеся при участии изофермента CYP3A4 (дигидропиридин иверапамил); некоторые иммунодепрессанты (циклоспорин, такролимус, сиролимус); другие препараты -дигоксин, карбамазепин, буспирон, альфентанил, алпразолам, бротизолам, рифабутин, метилпреднизолон, эбастин, ребоксетин.\u003Cbr\u003EПри одновременном применении с итраконазолом в случае необходимости дозу этих препаратов следует уменьшить.\u003Cbr\u003EПрепараты взаимодействия с которыми не обнаружено: взаимодействия между итраконазолом и зидовудином и флувастатином не обнаружено.\u003Cbr\u003EНе отмечалось влияния итраконазола на метаболизм этинилэстрадиола и норэтистерона.\u003Cbr\u003EИсследования in vitro продемонстрировали отсутствие взаимодействия между итраконазолом и такими препаратами, как имипрамин, пропранолол, диазепам, циметидин, индометацин, толбутамид и сульфаметазин, при связывании с белками плазмы."},{"name":"Регистрационный номер","value":"P N001638/01"},{"name":"Дата государственной регистрации","value":"24.09.2020"},{"name":"Владелец регистрационного удостоверения","value":"ВЕРОФАРМ","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["34324371:35649313","7893318:11037274"]}}},{"name":"Изготовитель","value":"ВЕРОФАРМ"},{"name":"Фасовщик","value":"ВЕРОФАРМ"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Ирунин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-gribka","categoryId":"15756513","navnodeId":"72474","glfilters":["17796364:18038530"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"5369331209865603442":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кожа, ногти, половая система"},{"name":"Назначение","value":"аспергиллез, бластомикоз, вагинальный кандидоз, гистоплазмоз, грибковый кератит, дерматомикозы, кандидоз, криптококкоз, онихомикозы, отрубевидный лишай, споротрихоз"},{"name":"Показания к применению","value":"Дерматомикозы; грибковый кератит; онихомикозы, вызванные дерматофитами и/или дрожжами и плесневыми грибами;\u003Cbr\u003Eсистемные микозы: системный аспергиллез и кандидоз, криптококкоз (включая криптококковый менингит), гистоплазмоз, споротрихоз, паракокцидиоидомикоз, бластомикоз и другие системные или тропические микозы; кандидомикозы с поражением кожи или слизистых, в том числе вульвовагинальный кандидоз; глубокие висцеральные кандидозы; отрубевидный лишай."},{"name":"Противопоказания","value":"Повышенная чувствительность к препарату или его составным частям."},{"name":"Состав","value":"Действующее вещество: итраконазол – 100 мг.\u003Cbr\u003EВспомогательные вещества: гипромеллоза (гидроксипропилметилцеллюлоза) – 130.17 мг, сополимер метакриловой кислоты (эудрагит) – 16.26 мг, метилпарагидроксибензоат (нипагин) – 0.08 мг, пропилпарагидроксибензоат (нипазол) – 0.01 мг, сахарная крупка – 163.17 мг, сахароза (сахар) – 54.31 мг.\u003Cbr/\u003E"},{"name":"Действующее вещество","value":"Итраконазол"},{"name":"Способ применения и дозы","value":"Для оптимальной абсорбции препарата необходимо принимать препарат в капсулах сразу после еды.\u003Cbr\u003EКапсулы следует проглатывать целиком.\u003Cbr\u003EПри различных показаниях: вульвовагинальный кандидоз-200 мг 2 раза/сут 1 день или 200 мг 1 раз/сут 3 дня; отрубевидный лишай-200 мг 1 раз/сут 7 дней; дерматомикозы гладкой кожи-200 мг 1 раз/сут 7 дней или 100 мг 1 раз/сут 15 дней; грибковый кератит-200 мг 1 раз/сут 21 день; поражения высококератинизированных областей, таких как кисти рук и стоп, требуют дополнительного лечения в течение 15 дней в дозе 100 мг/сут; оральный кандидоз-100 мг 1 раз/сут 15 дней.\u003Cbr\u003EТерапии при онихомикозах: по 200 мг (2 капс.) 2 раза/сут в течение 1 недели потом 3 недели интервал между курсами. При поражении ногтевых пластинок стоп с или бес поражения ногтевых пластинок кистей — 3 курса лечения. При поражении только ногтевых пластинок кистей — 2 курса лечения.\u003Cbr\u003EПри онихомикозах возможно применение непрерывной терапии: по 200 мг (2 капс.) 1 раз/сут в течение 3 месяцев. Выведение итраконазола из кожи и ногтевой пластинки осуществляется медленнее, чем из плазмы. Таким образом, оптимальные клинические и микологические эффекты достигаются через 2-4 нед. после окончания лечения при инфекциях кожи и через 6-9 мес после окончания лечения ногтевых инфекций.\u003Cbr\u003EРекомендуемые дозы при системных микозах в зависимости от вида инфекции: аспергиллез-200 мг 1 раз/сут 2-5 мес (увеличить дозу до 200 мг 2 раза/сут в случае инвазивных или диссеминированных форм); кандидоз-100-200 мг 1 раз/сут от 3 нед до 7 мес (увеличить дозу до 200 мг 2 раза/сут в случае инвазивных или диссеминированных форм); криптококкоз (кроме менингита)-200 мг 1 раз/сут от 2 мес до 1 года; криптококковый менингит-200 мг 2 раза/сут от 2 мес до 1 года; гистоплазмоз-200 мг 1 раз/сут-2 раза/сут 8 мес; споротрихоз-100 мг 1 раз/сут 3 месяцев; паракокцидиомикоз-100 мг 1 раз/сут 6мес; хромомикоз-100-200 мг 1 раз/сут 6мес; бластомикоз-от 100 мг 1 раз/сут до 200 мг 2 раза/сут 6 мес."},{"name":"Побочные действия","value":"Со стороны ЖКТ: диспепсия, тошнота, боль в животе и запор. Анорексия, головная боль, утомляемость, обратимое повышение активности печеночных ферментов, холестатическая желтуха, гепатит, нарушения менструального цикла, головокружение и аллергические реакции (такие как зуд, сыпь, крапивница и ангионевротический отек), периферическая нейропатия, синдром Стивенса-Джонсона, алопеция, гипокалиемия, отеки, застойная сердечная недостаточность и отек легких, окрашивание мочи в темный цвет, гиперкреатининемия.\u003Cbr\u003EВ очень редких случаях развивалось тяжелое токсическое поражение печени, в т.ч. случаи острой печеночной недостаточности с летальным исходом."},{"name":"Фармакологическое действие","value":"Противогрибковое широкого спектра.\u003Cbr\u003EПодавляет синтез эргостерола клеточной мембраны грибов. Активен в отношении дерматофитов (Trichophyton spp., Microsporum spp., Epidermophyton floccosum), дрожжевых грибов Candida spp. (включая Candida albicans, Candida parapsilosis), плесневых грибов (Cryptococcus neoformans, Aspergillus spp., Trichosporon spp., Geotrichum spp., Penicillium marneffei, Pseudallescheria boydii, Histoplasma spp., Coccidioides immitis, Paracoccidioides braziliensis, Sporothrix schenckii, Fonsecaea spp., Cladosporium spp., Blastomyces dermatidis), Malassezia spp.\u003Cbr\u003EНекоторые штаммы могут быть устойчивы: Candida glabrata, Candida krusei, Candida tropicalis, Absidia spp., Fusarium spp., Mucor spp., Rhizomucor spp., Rhizopus spp., Scedosporium proliferans, Scopulariopsis spp.\u003Cbr\u003EЭффективность лечения оценивается через 2-4 нед после прекращения терапии (при микозах), через 6-9 мес - при онихомикозах (по мере смены ногтей)."},{"name":"Фармакологическая группа","value":"противогрибковые средства"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Данные отсутствуют. В течение первого часа провести промывание желудка и, если это необходимо, назначить активированный уголь, симптоматическое лечение. Итраконазол не выводится при гемодиализе. Какого-либо специфического антидота не существует."},{"name":"Применение при беременности и кормлении грудью","value":"Беременным женщинам Ирунин следует назначать только в том случае, если ожидаемая польза для женщины превышает потенциальный риск для плода. Так как небольшое количество итраконазола выделяется с материнским молоком, в период лечения необходимо отказаться от грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не наблюдалось."},{"name":"Особые указания","value":"Итраконазол обладает отрицательным инотропным эффектом. Поэтому препарат не следует назначать пациентам с хронической сердечной недостаточностью (в т.ч. в анамнезе) за исключением случаев, когда ожидаемая польза терапии значительно превосходит потенциальный риск. При этом следует принимать во внимание такие факторы, как серьезность показаний, режим дозирования и индивидуальные факторы риска развития хронической сердечной недостаточности (в т.ч. наличие ИБС, поражений клапанов сердца, ХОБЛ, почечной недостаточности).\u003Cbr\u003EПри пониженной кислотности желудка абсорбция итраконазола нарушается. Пациентам, получающим антацидные препараты (например, алюминия гидроксид), рекомендуется принимать их не ранее чем через 2 ч после приема препарата. Пациентам с ахлоргидрией или применяющим блокаторы гистаминовых Н2-рецепторов или ингибиторы протонового насоса рекомендуется принимать капсулы, запивая колой.\u003Cbr\u003EВ очень редких случаях при применении итраконазола развивалось тяжелое токсическое поражение печени, в т.ч. случаи острой печеночной недостаточности с летальным исходом. В большинстве случаев это наблюдалось у пациентов, у которых уже имелись заболевания печени, а также у пациентов, получавших другие лекарственные средства, обладающие гепатотоксическим действием. В связи с этим рекомендуется регулярно контролировать функцию печени у пациентов, получающих терапию итраконазолом.\u003Cbr\u003EВ случае появления симптомов, предполагающих развитие гепатита, в т.ч. анорексии, тошноты, рвоты, слабости, болей в животе и потемнения мочи, необходимо немедленно прекратить прием препарата и провести исследование функции печени. Пациентам с повышенным уровнем печеночных ферментов или заболеванием печени в активной фазе не следует назначать лечение препаратом за исключением тех случаев, когда ожидаемая польза оправдывает риск поражения печени. В этих случаях необходимо во время лечения контролировать уровень печеночных ферментов.\u003Cbr\u003EВ случае развития невропатии, которая может быть вызвана пероральным приемом итраконазола, лечение следует прекратить.\u003Cbr\u003EНет данных о перекрестной гиперчувствительности к итраконазолу и другим противогрибковым препаратам - производным азола. Препарат в капсулах следует назначать с осторожностью пациентам с гиперчувствительностью к другим азолам.\u003Cbr\u003EС осторожностью: детский возраст; тяжелая сердечная недостаточность; заболевания печени (в том числе сопровождающиеся печеночной недостаточностью)."},{"name":"Взаимодействие","value":"Одновременное применение с индукторами микросомальных ферментов печени. Не рекомендуется одновременное применение с рифампицином, рифабутином и фенитоином , которые являются сильными индукторами микросомальных ферментов печени, т.к. эти препараты могут значительно снижать биодоступность итраконазола и гидроксиитраконазола, что приводит к существенному уменьшению эффективности препарата. Исследования по взаимодействию итраконазола с другими индукторами печеночных ферментов, такими как карбамазепин, фенобарбитал и изониазид, не проводились, однако можно предположить развитие аналогичного эффекта.\u003Cbr\u003EОдновременное применение с ингибитирами цитохрома P450.\u003Cbr\u003EТак как итраконазол в основном метаболизируется при участии изофермента CYP3A4 системы цитохрома P450, сильные ингибиторы этого фермента (в том числе ритонавир, индинавир, кларитромицин и эритромицин) могут увеличивать биодоступность итраконазола.\u003Cbr\u003EИтраконазол может ингибировать метаболизм препаратов, которые биотрансформируются при участии изофермента CYP3A4. Результатом этого может быть усиление или пролонгирование их действия, в том числе и побочных эффектов. После прекращения лечения концентрации итраконазола в плазме снижаются постепенно, в зависимости от дозы и длительности лечения.\u003Cbr\u003EОдновременно с итраконазолом нельзя назначать терфенадин, астемизол, мизоластин, цизаприд, триазолам, мидазолам (внутрь), дофетилид, хинидин, пимозид, метаболизирующиеся изоферментом CYP3A4, ингибиторы ГМГ-КоА-редуктазы (симвастатин и ловастатин).\u003Cbr\u003EОдновременное применение с блокаторами кальциевых каналов. Блокаторы кальциевых каналов обладают отрицательным инотропным эффектом, который может усиливать подобный эффект итраконазола; итраконазол может снижать метаболизм блокаторов кальциевых каналов. Следует с осторожностью применять итраконазол одновременно с блокаторами кальциевых каналов.\u003Cbr\u003EПрепараты, при применении которых требуется контроль концентраций в плазме крови: пероральные антикоагулянты; ингибиторы ВИЧ-протеазы (ритонавир, индинавир, саквинавир); некоторые противоопухолевые препараты (алкалоиды барвинка розового, бусульфан, доцетаксел, триметрексат); блокаторы кальциевых каналов, метаболизирующиеся при участии изофермента CYP3A4 (дигидропиридин иверапамил); некоторые иммунодепрессанты (циклоспорин, такролимус, сиролимус); другие препараты -дигоксин, карбамазепин, буспирон, альфентанил, алпразолам, бротизолам, рифабутин, метилпреднизолон, эбастин, ребоксетин.\u003Cbr\u003EПри одновременном применении с итраконазолом в случае необходимости дозу этих препаратов следует уменьшить.\u003Cbr\u003EПрепараты взаимодействия с которыми не обнаружено: взаимодействия между итраконазолом и зидовудином и флувастатином не обнаружено.\u003Cbr\u003EНе отмечалось влияния итраконазола на метаболизм этинилэстрадиола и норэтистерона.\u003Cbr\u003EИсследования in vitro продемонстрировали отсутствие взаимодействия между итраконазолом и такими препаратами, как имипрамин, пропранолол, диазепам, циметидин, индометацин, толбутамид и сульфаметазин, при связывании с белками плазмы."},{"name":"Регистрационный номер","value":"P N001638/01"},{"name":"Дата государственной регистрации","value":"24.09.2020"},{"name":"Владелец регистрационного удостоверения","value":"ВЕРОФАРМ"},{"name":"Изготовитель","value":"ВЕРОФАРМ"},{"name":"Фасовщик","value":"ВЕРОФАРМ"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Ирунин"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_9896387789983059400"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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  • 911+ Ваша служба спасения Ногтимицин крем, 52 г, 30 мл, 1 шт., 1 уп.
    –2 %
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    911+ Ваша служба спасения Ногтимицин крем, 52 г, 30 мл, 1 шт., 1 уп.

    Рейтинг товара: 4.5 из 5
    на основе 60 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 304 ₽ вместо 310
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  • Domix Green средство для ногтей Стоп грибок фл., 250 г, 18 мл, 1 шт.
    –50 %
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    Domix Green средство для ногтей Стоп грибок фл., 250 г, 18 мл, 1 шт.

    Рейтинг товара: 4.6 из 5
    на основе 116 оценок
    Цена 327 ₽ вместо 656
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  • Мизол спрей, 50 мл
    –1 %
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    Мизол спрей, 50 мл

    Рейтинг товара: 4.9 из 5
    на основе 33 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 954 ₽ вместо 964
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  • Миколепт лак, 10 мл
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    Миколепт лак, 10 мл

    Рейтинг товара: 4.7 из 5
    на основе 27 оценок
    Цена 765 ₽
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  • Domix Green лак д/ногтей Стоп грибок, 20 г, 17 мл, 1 уп.
    –50 %
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    Domix Green лак д/ногтей Стоп грибок, 20 г, 17 мл, 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 148 оценок
    Цена 394 ₽ вместо 792
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  • Domix Green средство для ногтей Профессиональный уход фл., 18 мл
    –46 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-famac0im7ca/toggleWishlist":{"skuId":"101905614769","productId":1808599125,"offerId":"bow8kokgsIAhNgJIiTI4rg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ8v2j5fe/iNdEEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI1ZC03gYQsY+x0PsCGM3Cswgg4dnBBw==","sign":"TvNAnIy0mwm2ZWoMZb9JSVvGPFBGl0AvP8cRvpwPbNo="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-famac0im7ca/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Domix Green средство для ногтей Профессиональный уход фл., 18 мл

    Рейтинг товара: 4.8 из 5
    на основе 54 оценки
    Цена 356 ₽ вместо 658
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  • Микостоп крем-паста д/нар. прим. для ногтей, 20 мл, 1 шт.
    –1 %
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    Микостоп крем-паста д/нар. прим. для ногтей, 20 мл, 1 шт.

    Рейтинг товара: 4.2 из 5
    на основе 6 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 324 ₽ вместо 327
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  • Микостоп набор, 15 мл, 1 шт.
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    Микостоп набор, 15 мл, 1 шт.

    Рейтинг товара: 4.7 из 5
    на основе 20 оценок
    Цена 503 ₽
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  • Мизол гель, 10 г
    –1 %
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    Мизол гель, 10 г

    Рейтинг товара: 3.9 из 5
    на основе 15 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 362 ₽ вместо 366
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Инструкция

Показания к применению

Дерматомикозы; грибковый кератит; онихомикозы, вызванные дерматофитами и/или дрожжами и плесневыми грибами;
системные микозы: системный аспергиллез и кандидоз, криптококкоз (включая криптококковый менингит), гистоплазмоз, споротрихоз, паракокцидиоидомикоз, бластомикоз и другие системные или тропические микозы; кандидомикозы с поражением кожи или слизистых, в том числе вульвовагинальный кандидоз; глубокие висцеральные кандидозы; отрубевидный лишай.

Противопоказания

Повышенная чувствительность к препарату или его составным частям.

Способ применения и дозы

Для оптимальной абсорбции препарата необходимо принимать препарат в капсулах сразу после еды.
Капсулы следует проглатывать целиком.
При различных показаниях: вульвовагинальный кандидоз-200 мг 2 раза/сут 1 день или 200 мг 1 раз/сут 3 дня; отрубевидный лишай-200 мг 1 раз/сут 7 дней; дерматомикозы гладкой кожи-200 мг 1 раз/сут 7 дней или 100 мг 1 раз/сут 15 дней; грибковый кератит-200 мг 1 раз/сут 21 день; поражения высококератинизированных областей, таких как кисти рук и стоп, требуют дополнительного лечения в течение 15 дней в дозе 100 мг/сут; оральный кандидоз-100 мг 1 раз/сут 15 дней.
Терапии при онихомикозах: по 200 мг (2 капс.) 2 раза/сут в течение 1 недели потом 3 недели интервал между курсами. При поражении ногтевых пластинок стоп с или бес поражения ногтевых пластинок кистей — 3 курса лечения. При поражении только ногтевых пластинок кистей — 2 курса лечения.
При онихомикозах возможно применение непрерывной терапии: по 200 мг (2 капс.) 1 раз/сут в течение 3 месяцев. Выведение итраконазола из кожи и ногтевой пластинки осуществляется медленнее, чем из плазмы. Таким образом, оптимальные клинические и микологические эффекты достигаются через 2-4 нед. после окончания лечения при инфекциях кожи и через 6-9 мес после окончания лечения ногтевых инфекций.
Рекомендуемые дозы при системных микозах в зависимости от вида инфекции: аспергиллез-200 мг 1 раз/сут 2-5 мес (увеличить дозу до 200 мг 2 раза/сут в случае инвазивных или диссеминированных форм); кандидоз-100-200 мг 1 раз/сут от 3 нед до 7 мес (увеличить дозу до 200 мг 2 раза/сут в случае инвазивных или диссеминированных форм); криптококкоз (кроме менингита)-200 мг 1 раз/сут от 2 мес до 1 года; криптококковый менингит-200 мг 2 раза/сут от 2 мес до 1 года; гистоплазмоз-200 мг 1 раз/сут-2 раза/сут 8 мес; споротрихоз-100 мг 1 раз/сут 3 месяцев; паракокцидиомикоз-100 мг 1 раз/сут 6мес; хромомикоз-100-200 мг 1 раз/сут 6мес; бластомикоз-от 100 мг 1 раз/сут до 200 мг 2 раза/сут 6 мес.
Полная инструкция
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Ирунин капс.
Ирунин капс., 100 мг, 14 шт.
4.4
(11)
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Задать вопрос
Инструкция
Нет в продаже
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4.4
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У продавца:11 оценок·3 отзыва
У всех продавцов:90 оценок·26 отзывов
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user avatar
Год назад • Karine Oganesyan • Куплен на Маркете
Достоинства: Работает и справляется поставленной задачей отлично
Недостатки: Нет
Комментарий: Рекомендую препарат
user avatar
8 месяцев назад • Анна А. • Куплен на Маркете
Достоинства: Эффективное средство
user avatar
Год назад • Valentina Mihailovna • Куплен на Маркете
Достоинства: Ни какого действия.
Посмотреть все отзывы на Маркете
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    Цена 327 ₽ вместо 656
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

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  • Таблетница из 14 секций на семь дней Утро-вечер
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    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 167 ₽ вместо 200
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    Реклама
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  • Миколепт лак, 10 мл
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    Миколепт лак, 10 мл

    Цена 765 ₽
  • Таблетница на неделю AXLER Home контейнер органайзер для таблеток, маленькая таблеточница бокс для лекарств на 7 дней, кейс на 1 прием
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    Таблетница на неделю AXLER Home контейнер органайзер для таблеток, маленькая таблеточница бокс для лекарств на 7 дней, кейс на 1 прием

    Цена 180 ₽ вместо 221
  • Таблетница на день мини для капсул контейнер для таблеток белый
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    Таблетница на день мини для капсул контейнер для таблеток белый

    Цена 282 ₽ вместо 750
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 781 ₽ вместо 1 890
  • Domix Green лак д/ногтей Стоп грибок, 20 г, 17 мл, 1 уп.
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    Domix Green лак д/ногтей Стоп грибок, 20 г, 17 мл, 1 уп.

    Цена 394 ₽ вместо 792
  • Domix Green средство для ногтей Профессиональный уход фл., 18 мл
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    Domix Green средство для ногтей Профессиональный уход фл., 18 мл

    Цена 356 ₽ вместо 658
  • Микостоп крем-паста д/нар. прим. для ногтей, 20 мл, 1 шт.
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    Микостоп крем-паста д/нар. прим. для ногтей, 20 мл, 1 шт.

    Цена 324 ₽ вместо 327
  • Контейнер для хранения/таблетница/кейс для таблеток
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    Контейнер для хранения/таблетница/кейс для таблеток

    Цена 367 ₽ вместо 699
  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)
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    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)

    Цена 245 ₽ вместо 263
  • Мизол гель, 10 г
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    Мизол гель, 10 г

    Цена 362 ₽ вместо 366
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 400 ₽ вместо 637
  • Таблетница на 7 дней Органайзер для лекарств
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    Таблетница на 7 дней Органайзер для лекарств

    Цена 273 ₽ вместо 279
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    Реклама
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  • Микостоп набор, 15 мл, 1 шт.
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    Микостоп набор, 15 мл, 1 шт.

    Цена 503 ₽
  • Таблетница на 7 дней Органайзер для лекарств
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    Таблетница на 7 дней Органайзер для лекарств

    Цена 273 ₽ вместо 279
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