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Кальций цитрат обеспечивает усвоение кальция вне зависимости от функционального состояния ЖКТ, что применимо для лечения пациентов со сниженной секреторной функцией ЖКТ, а также на фоне лечения препаратами для снижения секреции; снижает уровень маркеров резорбции костной ткани, что свидетельствует о замедлении процессов разрушения костной ткани; регулирует содержание паратиреоидного гормона, что приводит к улучшению регуляции кальциевого гомеостаза; не увеличивает содержание оксалатов и кальция в моче, следовательно не вызывает образования камней в почках; не блокирует усвоение железа, что снижает риск развития железодефицитной анемии.\u003Cbr\u003EКолекальциферол (витамин D3) регулирует обмен кальция и фосфора в организме, участвует в формировании костного скелета, способствует сохранению структуры костей, усиливает всасывание кальция в кишечнике и реабсорбцию фосфора в почечных канальцах.\u003Cbr\u003EЦинк способствует синтезу половых гормонов, что препятствует разрушению костной ткани.\u003Cbr\u003EМарганец участвует в образовании протеогликанов, что улучшает качество костной ткани и формирует протеиновый матрикс костной ткани.\u003Cbr\u003EМедь участвует в синтезе коллагена и эластина, входящего в состав костной и соединительной ткани, что оказывает влияние на процессы образования костной массы.\u003Cbr\u003EБор снижает избыточную активность паратиреоидного гормона, улучшает абсорбцию кальция, уменьшает риск развития дефицита колекальциферола, способствует предотвращению остеопороза."},{"description":"","filters":[{"id":50921473,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"Действующее вещество: кальций (в форме цитрата и карбоната) – 250 мг, колекальциферол (вит. D3) – 50 МЕ, цинк (в форме оксида) – 2 мг, медь (в форме оксида) – 500 мкг, марганец (в форме сульфата) – 500 мкг, бор (в форме натрия бората декагидрата) – 50 мкг.\u003Cbr\u003EВспомогательные вещества: полисахарид сои – 10 мг, натрия лаурилсульфат – 5 мг, кремния диоксид коллоидный – 3.9 мг, кроскармеллоза натрия – 28 мг, целлюлоза микрокристаллическая – 199.45 мг, стеариновая кислота – 35 мг, магния стеарат – 10 мг.\u003Cbr/\u003E"},{"description":"","filters":[{"id":50921347,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"При одновременном применении препарата Кальцемин с витамином А уменьшается токсичность витамина D3.\u003Cbr\u003EФенитоин, барбитураты, глюкокортикоиды уменьшают эффективность витамина D3.\u003Cbr\u003EСлабительные средства снижают абсорбцию витамина D3.\u003Cbr\u003EГлюкокортикоиды, гормональные контрацептивные средства для системного применения, левотироксин ухудшают всасывание ионов кальция.\u003Cbr\u003EПри одновременном применении с тетрациклином интервал между приемами должен составлять не менее 3 ч, с бисфосфонатами и натрия фторидом - не менее 2 ч (нарушается их всасывание).\u003Cbr\u003EПри совместном применении препарата Кальцемин с сердечными гликозидами повышается токсичность последних (необходим контроль ЭКГ и клинического состояния).\u003Cbr\u003EПри одновременном применении с тиазидными диуретиками увеличивается риск развития гиперкальциемии, с фуросемидом и другими \"петлевыми\" диуретиками - увеличивается выведение кальция почками.\u003Cbr\u003EНе следует применять Кальцемин одновременно с блокаторами кальциевых каналов.\u003Cbr\u003EНе рекомендуется одновременное применение препарата с антацидами, которые содержат алюминий, из-за снижения их эффективности."},{"description":"","filters":[{"id":50921465,"name":"Показания к применению"}],"isMainProperty":false,"name":"Показания к применению","value":"— профилактика и комплексное лечение остеопороза различного генеза;\u003Cbr\u003E— восполнение дефицита кальция и микроэлементов у детей и подростков;\u003Cbr\u003E— восполнение дефицита кальция и микроэлементов у женщин при беременности и в период грудного вскармливания."},{"description":"","filters":[{"id":50925451,"name":"Противопоказания"}],"isMainProperty":false,"name":"Противопоказания","value":"— почечная недостаточность тяжелой степени;\u003Cbr\u003E— нефролитиаз;\u003Cbr\u003E— гипервитаминоз витамина D;\u003Cbr\u003E— активная форма туберкулеза;\u003Cbr\u003E— гиперкальциемия;\u003Cbr\u003E— гиперкальциурия;\u003Cbr\u003E— декальцинирующие опухоли (миелома, костные метастазы, саркоидоз);\u003Cbr\u003E— детский возраст до 5 лет;\u003Cbr\u003E— повышенная чувствительность к компонентам препарата.\u003Cbr\u003EС осторожностью следует назначать препарат при доброкачественном гранулематозе, одновременном применении сердечных гликозидов и тиазидных диуретиков, беременности, в период лактации."},{"description":"","filters":[{"id":50921469,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Препарат принимают внутрь.\u003Cbr\u003EВзрослым и детям старше 12 лет назначают по 1 таб. 2 раза/сут во время приема пищи.\u003Cbr\u003EДетям в возрасте от 5 до 12 лет назначают по 1 таб. 1 раз/сут во время приема пищи.\u003Cbr\u003EС 20-й недели беременности и в течение всего периода грудного вскармливания назначают по 1 таб. 2 раза/сут.\u003Cbr\u003EМинимальная продолжительность применения препарата для лечения остеопороза в составе комплексной терапии у взрослых составляет 3 мес, с целью профилактики остеопороза у взрослых - 1 мес, при дефиците кальция и микроэлементов у детей и взрослых - 2-3 мес. Увеличение продолжительности применения препарата возможно только после консультации с врачом.\u003Cbr\u003EПовторный курс приема препарата возможен через 1 мес после окончания лечения."},{"description":"","filters":[{"id":50921474,"name":"Применение при беременности"}],"isMainProperty":false,"name":"Применение при беременности","value":"В период беременности и грудного вскармливания прием препарата следует согласовать с врачом.\n\nСуточная доза не должна превышать 1500 мг кальция и 600 ME витамина D3, гиперкальциемия, развивающаяся на фоне передозировки в период беременности может вызвать дефекты умственного и физического развития у плода. У кормящих женщин следует учитывать, что колекальциферол и его метаболиты проникают в грудное молоко, поэтому необходимо учитывать поступление кальция и витамина D3."},{"description":"","filters":[{"id":14805991,"name":"Пол"}],"isMainProperty":false,"name":"Пол","value":"для женщин"},{"description":"","filters":[{"id":50921464,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Со стороны пищеварительной системы: тошнота, рвота, метеоризм, диарея, запор.\u003Cbr\u003EСо стороны обмена веществ: гиперкальциемия и гиперкальциурия.\u003Cbr\u003EАллергические реакции: зуд, сыпь, крапивница."},{"description":"","filters":[{"id":50921468,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"При передозировке препарата возможно развитие гипервитаминоза D, гиперкальциемии и гиперкальциурии.\u003Cbr\u003EСимптомы: снижение аппетита, жажда, полиурия, головокружение, обморочные состояния, запор, тошнота и рвота. При длительном применении в высоких дозах - кальциноз сосудов и тканей.\u003Cbr\u003EЛечение: необходимо уменьшить дозу или прекратить применение препарата. При случайной передозировке следует вызвать рвоту, промыть желудок. Показано проведение симптоматической терапии."},{"description":"","filters":[{"id":50921467,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 25°C."},{"description":"","filters":[{"id":50921466,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"При применении препарата не следует превышать рекомендуемые дозы, т.к. повышенное потребление кальция может угнетать всасывание в кишечнике железа, цинка и других необходимых минералов"},{"description":"","filters":[{"id":32849454,"name":"Страна бренда"}],"isMainProperty":false,"name":"Страна бренда","value":"США"},{"description":"","filters":[{"id":34362170,"name":"Владелец регистрационного удостоверения"}],"isMainProperty":false,"name":"Владелец регистрационного 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