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Описание

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Касодекс таб. п/о плен., 50 мг, 28 шт.

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5.0
(1)
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Дозировка: 50 мг

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Коротко о товаре

Артикул Маркета
3123251015
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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Т1-Т2, N+, М0) в качестве монотерапии или адъювантной терапии в сочетании с радикальной простатэктомией или радиотерапией;\u003Cbr\u003E- Касодекс в дозе 150 мг также показан для лечения местнораспространенного, неметастатического рака предстательной железы в случаях, когда хирургическая кастрация или другие медицинские вмешательства неприемлемы или не подходят пациенту"},{"name":"Противопоказания","value":"- Повышенная чувствительность к бикалутамиду или другим компонентам препарата;\u003Cbr\u003E- одновременный прием с терфенадином, астемизолом и цизапридом;\u003Cbr\u003E- Касодекс не должен назначаться детям и женщинам."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: бикалутамид 150 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат 183,0 мг, карбоксиметилкрахмал натрия 22,5 мг, повидон 15,0 мг, магния стеарат 4,5 мг;\u003Cbr\u003Eсостав оболочки: гипромеллоза 7,5 мг, макрогол 300 1,5 мг, титана диоксид (Е171) 2,3 мг.\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивный ингредиент: бикалутамид 50 мг;\u003Cbr\u003Eвспомогательные ингредиенты: лактозы моногидрат 61 мг, карбоксиметилкрахмал натрия 7,5 мг, повидон 5,0 мг, магния стеарат 1,5 мг;\u003Cbr\u003Eсостав оболочки: гипромеллоза 2,5 мг, макрогол 300 0,5 мг, титана диоксид (Е171) 0,77 мг."},{"name":"Действующее вещество","value":"Бикалутамид","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["27144131:28709949"]}}},{"name":"Способ применения и дозы","value":"Взрослые мужчины (в том числе пожилые):\u003Cbr\u003EПри распространенном раке предстательной железы в комбинации с аналогом ГнРГ или хирургической кастрацией: внутрь по 50 мг один раз в сутки. Лечение препаратом Касодекс необходимо начинать одновременно с началом приема аналога ГнРГ или хирургической кастрацией.\u003Cbr\u003EПри местнораспространенном раке предстательной железы: внутрь по 150 мг один раз в сутки. Касодекс следует принимать длительно, как минимум в течение 2-х лет.\u003Cbr\u003EПри появлении признаков прогрессирования заболевания прием препарата следует прекратить.\u003Cbr\u003EНарушения функции почек: коррекции дозы не требуется.\u003Cbr\u003EНарушения функции печени: при легком нарушении функции печени коррекция дозы не требуется. У пациентов со средним и тяжелым нарушением функции печени может наблюдаться повышенная кумуляция препарата Касодекс."},{"name":"Побочные действия","value":"Касодекс, в целом, обладает хорошей переносимостью, лишь в редких случаях препарат отменяют из-за вызванных побочных эффектов.\u003Cbr\u003EФармакологическое действие бикалутамида может обуславливать следующие побочные эффекты; \u003Cbr\u003E- очень часто (\u003E10%): гинекомастия (может сохраняться даже после прекращения терапии, особенно в случае приема препарата в течение длительного времени), болезненность грудных желез, астения, сыпь. \u003Cbr\u003E- часто (≥1% - \u003C 10%): “приливы” жара, анемия, головокружение, боль в животе, запор, тошнота, периферические отеки, гематурия, гепатотоксичность, транзиторное повышение активности “печеночных” трансаминаз, желтуха (описанные изменения функции печени редко оценивались как серьезные, часто носили транзиторный характер, полностью исчезали или уменьшались при продолжении терапии или после отмены препарата), снижение аппетита, снижение либидо, депрессия, сонливость, диспепсия, метеоризм, алопеция, гирсутизм или восстановление роста волос, сухость кожи, кожный зуд, эректильная дисфункция, боль в груди, увеличение массы тела, инфаркт миокарда (сообщалось о случаях с фатальным исходом), сердечная недостаточность.\u003Cbr\u003E- редко (≥0,1% - \u003C1%): реакции повышенной чувствительности, ангионевротический отек, крапивница, интерстициальные легочные заболевания (сообщалось о случаях с фатальным исходом), реакция фоточувствительности.\u003Cbr\u003E- очень редко (≥0,01% - \u003C0,1 %): печеночная недостаточность (сообщалось о случаях с фатальным исходом)."},{"name":"Фармакологическое действие","value":"Касодекс представляет собой рацемическую смесь с нестероидной антиандрогенной активностью преимущественно (R)-энантиомера, не обладает иной эндокринной активностью. Касодекс связывается с андрогенными рецепторами и, не активируя экспрессию генов, подавляет стимулирующее влияние андрогенов. Результатом этого является регрессия злокачественных новообразований предстательной железы.\u003Cbr\u003EУ некоторых пациентов прекращение приема препарата Касодекс может привести к развитию клинического синдрома \"отмены\" антиандрогенов.\u003Cbr\u003EДля дозировки 150 мг:\u003Cbr\u003EКасодекс представляет собой рацемическую смесь с нестероидной антиандрогенной активностью преимущественно (R)-энантиомера, не обладает иной эндокринной активностью.\u003Cbr\u003EКасодекс связывается с андрогенными рецепторами и, не активируя экспрессию генов, подавляет стимулирующее влияние андрогенов. Результатом этого является регрессия злокачественных новообразований предстательной железы.\u003Cbr\u003EУ некоторых пациентов прекращение приема препарата Касодекс может привести к развитию клинического синдрома “отмены” антиандрогенов.\u003Cbr\u003EПри применении препарата Касодекс в суточной дозе 150 мг ежедневно для лечения пациентов с местнораспространенным (Т3-Т4, любое N, М0 или любое Т, N+, М0) раком предстательной железы, в качестве немедленной гормональной терапии или в качестве адьювантной терапии, значительно снижается риск прогрессирования заболевания и метастазов в кости.\u003Cbr\u003EПри местнораспространенном раке предстательной железы отмечена тенденция к улучшению показателей продолжительности жизни без признаков прогрессирования заболевания в группах пациентов, принимавших Касодекс 150 мг в качестве немедленной терапии или адьювантной терапии, по сравнению со стандартной терапией (хирургическое лечение, лучевая терапия).\u003Cbr\u003EПоказано увеличение продолжительности жизни среди пациентов с местнораспространенным раком предстательной железы, получавших Касодекс в дозе 150 мг в качестве немедленной монотерапии и в качестве адъювантного лечения в комбинации с лучевой терапией.\u003Cbr\u003EПрименение препарата Касодекс в дозе 150 мг по сравнению с хирургической кастрацией у пациентов с местнораспространенным неметастатическим раком предстательной железы не выявило статистически достоверного различия в продолжительности жизни и времени до прогрессирования при статистически достоверном преимуществе сексуальной функции и физического состояния.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"противоопухолевые средства","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34045110:34518988"]}}},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["35947170:36763744"]}}},{"name":"Пол","value":"для мужчин"},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 30°C."},{"name":"Передозировка","value":"Случай передозировки у человека не описаны.\u003Cbr\u003EСпецифического антидота не существует.\u003Cbr\u003EЛечение симптоматическое. Проведение диализа неэффективно, так как бикалутамид прочно связывается с белками и не выводится с мочой в неизмененном виде. Показана общая поддерживающая терапия и мониторинг жизненно важных функций организма."},{"name":"Применение при беременности и кормлении грудью","value":"Касодекс противопоказан женщинам и не должен назначаться беременным или в период лактации."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При применении препарата Касодекс может наблюдаться сонливость и головокружение, в связи с чем следует соблюдать осторожность при управлении автотранспортом или иными движущимися механизмами."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003E- Нарушение функции печени;\u003Cbr\u003E- непереносимость лактозы, дефицит лактазы и глюкозо-галактозная мальабсорбция.\u003Cbr\u003EУчитывая возможность замедления выведения бикалутамида и кумуляции бикалутамида у больных с нарушением функции печени, целесообразно периодически оценивать функцию печени. Большинство изменений функции печени встречаются в течение первых шести месяцев лечения препаратом Касодекс.\u003Cbr\u003EВ случае развития выраженных изменений функции печени прием препарата Касодекс необходимо прекратить.\u003Cbr\u003EУ пациентов с прогрессированием заболевания на фоне повышения концентрации простатспецифического антигена (ПСА) необходимо рассмотреть вопрос о прекращении лечения препаратом Касодекс.\u003Cbr\u003EПри назначении препарата Касодекс пациентам, получающим антикоагулянты кумаринового ряда, рекомендуется регулярно контролировать протромбиновое время.\u003Cbr\u003EУчитывая возможность ингибирования препаратом Касодекс активности цитохрома Р450 (изофермента CYP 3А4), следует проявлять осторожность при одновременном применении препарата Касодекс с препаратами, преимущественно метаболизирующимися с участием изофермента CYP 3А4.\u003Cbr\u003EПациентов с непереносимостью лактозы необходимо проинформировать о том, что каждая таблетка препарата Касодекс 150 мг содержит 183 мг моногидрата лактозы.\u003Cbr\u003EРекомендуется регулярно контролировать протромбиновое время при назначении препарата Касодекс пациентам, получающим непрямые антикоагулянты кумаринового ряда."},{"name":"Взаимодействие","value":"Доказательств фармакокинетического или фармакодинамического взаимодействия между препаратом Касодекс и аналогами ГнРГ не получено. \u003Cbr\u003EВ исследованиях in vitro показано, что (R)-энантиомер бикалутамида является ингибитором изофермента CYP 3А4, в меньшей степени влияя на активность изоферментов CYP 2С9, 2С19 и 2D6. В клинических исследованиях с использованием феназона в качестве маркера активности цитохрома Р450 (CYP) не обнаружено потенциальной способности препарата Касодекс к взаимодействию с другими лекарственными препаратами, однако при применении препарата Касодекс в течение 28 дней на фоне приема мидазолама площадь под кривой “концентрация-время” (AUC) мидазолама увеличивалась на 80%.\u003Cbr\u003EПротивопоказано одновременное применение препарата Касодекс с такими препаратами, как терфенадин, астемизол и цизаприд.\u003Cbr\u003EСледует соблюдать осторожность при применении препарата Касодекс одновременно с циклоспорином или блокаторами “медленных” кальциевых каналов. Возможно, потребуется снижение дозы этих препаратов, особенно в случае развития побочных явлений. После начала применения или отмены препарата Касодекс рекомендуется проводить тщательный мониторинг концентрации циклоспорина в плазме и клинического состояния пациента.\u003Cbr\u003EПроявлять осторожность при одновременном применении препарата Касодекс и препаратов, ингибирующих микросомальные ферменты печени, например, с циметидином или кетоконазолом. Одновременное применение может привести к увеличению концентрации бикалутамида в плазме и, возможно, к увеличению частоты возникновения побочных эффектов.\u003Cbr\u003EУсиливает действие непрямых антикоагулянтов кумаринового ряда, в том числе варфарина (конкуренция за связь с белками). Рекомендуется регулярно контролировать протромбиновое время при назначении препарата Касодекс пациентам, получающим непрямые антикоагулянты кумаринового ряда.\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"П N013043/01\nП N013292/01"},{"name":"Дата государственной регистрации","value":"12.07.2018\n17.07.2018"},{"name":"Владелец регистрационного удостоверения","value":"AstraZeneca","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["34324371:35649313","7893318:16002703"]}}},{"name":"Изготовитель","value":"Corden Pharma GmbH"},{"name":"Страна бренда","value":"Великобритания"},{"name":"Страна-производитель","value":"Германия"},{"name":"Название препарата","value":"Касодекс","transition":{"type":"catalog","params":{"categorySlug":"protivoopukholevye-preparaty-i-immunomoduliatory","categoryId":"15756914","navnodeId":"72508","glfilters":["17796364:18050218"]}}},{"name":"Срок годности","value":"59 мес."}]}},"fullSpecsGrouped":{"7665687251808593834":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"половая система, половые железы"},{"name":"Назначение","value":"рак предстательной железы"},{"name":"Показания к применению","value":"- Касодекс в дозе 50 мг в комбинации с аналогом ГнРГ (гонадотропин-рилизинг гормон) или хирургической кастрацией показан для лечения распространенного рака предстательной железы;\u003Cbr\u003E- Касодекс в дозе 150 мг показан для лечения местнораспространенного рака предстательной железы (Т3-Т4, любая N, М0; Т1-Т2, N+, М0) в качестве монотерапии или адъювантной терапии в сочетании с радикальной простатэктомией или радиотерапией;\u003Cbr\u003E- Касодекс в дозе 150 мг также показан для лечения местнораспространенного, неметастатического рака предстательной железы в случаях, когда хирургическая кастрация или другие медицинские вмешательства неприемлемы или не подходят пациенту"},{"name":"Противопоказания","value":"- Повышенная чувствительность к бикалутамиду или другим компонентам препарата;\u003Cbr\u003E- одновременный прием с терфенадином, астемизолом и цизапридом;\u003Cbr\u003E- Касодекс не должен назначаться детям и женщинам."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: бикалутамид 150 мг;\u003Cbr\u003Eвспомогательные вещества: лактозы моногидрат 183,0 мг, карбоксиметилкрахмал натрия 22,5 мг, повидон 15,0 мг, магния стеарат 4,5 мг;\u003Cbr\u003Eсостав оболочки: гипромеллоза 7,5 мг, макрогол 300 1,5 мг, титана диоксид (Е171) 2,3 мг.\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивный ингредиент: бикалутамид 50 мг;\u003Cbr\u003Eвспомогательные ингредиенты: лактозы моногидрат 61 мг, карбоксиметилкрахмал натрия 7,5 мг, повидон 5,0 мг, магния стеарат 1,5 мг;\u003Cbr\u003Eсостав оболочки: гипромеллоза 2,5 мг, макрогол 300 0,5 мг, титана диоксид (Е171) 0,77 мг."},{"name":"Действующее вещество","value":"Бикалутамид"},{"name":"Способ применения и дозы","value":"Взрослые мужчины (в том числе пожилые):\u003Cbr\u003EПри распространенном раке предстательной железы в комбинации с аналогом ГнРГ или хирургической кастрацией: внутрь по 50 мг один раз в сутки. Лечение препаратом Касодекс необходимо начинать одновременно с началом приема аналога ГнРГ или хирургической кастрацией.\u003Cbr\u003EПри местнораспространенном раке предстательной железы: внутрь по 150 мг один раз в сутки. Касодекс следует принимать длительно, как минимум в течение 2-х лет.\u003Cbr\u003EПри появлении признаков прогрессирования заболевания прием препарата следует прекратить.\u003Cbr\u003EНарушения функции почек: коррекции дозы не требуется.\u003Cbr\u003EНарушения функции печени: при легком нарушении функции печени коррекция дозы не требуется. У пациентов со средним и тяжелым нарушением функции печени может наблюдаться повышенная кумуляция препарата Касодекс."},{"name":"Побочные действия","value":"Касодекс, в целом, обладает хорошей переносимостью, лишь в редких случаях препарат отменяют из-за вызванных побочных эффектов.\u003Cbr\u003EФармакологическое действие бикалутамида может обуславливать следующие побочные эффекты; \u003Cbr\u003E- очень часто (\u003E10%): гинекомастия (может сохраняться даже после прекращения терапии, особенно в случае приема препарата в течение длительного времени), болезненность грудных желез, астения, сыпь. \u003Cbr\u003E- часто (≥1% - \u003C 10%): “приливы” жара, анемия, головокружение, боль в животе, запор, тошнота, периферические отеки, гематурия, гепатотоксичность, транзиторное повышение активности “печеночных” трансаминаз, желтуха (описанные изменения функции печени редко оценивались как серьезные, часто носили транзиторный характер, полностью исчезали или уменьшались при продолжении терапии или после отмены препарата), снижение аппетита, снижение либидо, депрессия, сонливость, диспепсия, метеоризм, алопеция, гирсутизм или восстановление роста волос, сухость кожи, кожный зуд, эректильная дисфункция, боль в груди, увеличение массы тела, инфаркт миокарда (сообщалось о случаях с фатальным исходом), сердечная недостаточность.\u003Cbr\u003E- редко (≥0,1% - \u003C1%): реакции повышенной чувствительности, ангионевротический отек, крапивница, интерстициальные легочные заболевания (сообщалось о случаях с фатальным исходом), реакция фоточувствительности.\u003Cbr\u003E- очень редко (≥0,01% - \u003C0,1 %): печеночная недостаточность (сообщалось о случаях с фатальным исходом)."},{"name":"Фармакологическое действие","value":"Касодекс представляет собой рацемическую смесь с нестероидной антиандрогенной активностью преимущественно (R)-энантиомера, не обладает иной эндокринной активностью. Касодекс связывается с андрогенными рецепторами и, не активируя экспрессию генов, подавляет стимулирующее влияние андрогенов. Результатом этого является регрессия злокачественных новообразований предстательной железы.\u003Cbr\u003EУ некоторых пациентов прекращение приема препарата Касодекс может привести к развитию клинического синдрома \"отмены\" антиандрогенов.\u003Cbr\u003EДля дозировки 150 мг:\u003Cbr\u003EКасодекс представляет собой рацемическую смесь с нестероидной антиандрогенной активностью преимущественно (R)-энантиомера, не обладает иной эндокринной активностью.\u003Cbr\u003EКасодекс связывается с андрогенными рецепторами и, не активируя экспрессию генов, подавляет стимулирующее влияние андрогенов. Результатом этого является регрессия злокачественных новообразований предстательной железы.\u003Cbr\u003EУ некоторых пациентов прекращение приема препарата Касодекс может привести к развитию клинического синдрома “отмены” антиандрогенов.\u003Cbr\u003EПри применении препарата Касодекс в суточной дозе 150 мг ежедневно для лечения пациентов с местнораспространенным (Т3-Т4, любое N, М0 или любое Т, N+, М0) раком предстательной железы, в качестве немедленной гормональной терапии или в качестве адьювантной терапии, значительно снижается риск прогрессирования заболевания и метастазов в кости.\u003Cbr\u003EПри местнораспространенном раке предстательной железы отмечена тенденция к улучшению показателей продолжительности жизни без признаков прогрессирования заболевания в группах пациентов, принимавших Касодекс 150 мг в качестве немедленной терапии или адьювантной терапии, по сравнению со стандартной терапией (хирургическое лечение, лучевая терапия).\u003Cbr\u003EПоказано увеличение продолжительности жизни среди пациентов с местнораспространенным раком предстательной железы, получавших Касодекс в дозе 150 мг в качестве немедленной монотерапии и в качестве адъювантного лечения в комбинации с лучевой терапией.\u003Cbr\u003EПрименение препарата Касодекс в дозе 150 мг по сравнению с хирургической кастрацией у пациентов с местнораспространенным неметастатическим раком предстательной железы не выявило статистически достоверного различия в продолжительности жизни и времени до прогрессирования при статистически достоверном преимуществе сексуальной функции и физического состояния.\u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"противоопухолевые средства"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Пол","value":"для мужчин"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 30°C."},{"name":"Передозировка","value":"Случай передозировки у человека не описаны.\u003Cbr\u003EСпецифического антидота не существует.\u003Cbr\u003EЛечение симптоматическое. Проведение диализа неэффективно, так как бикалутамид прочно связывается с белками и не выводится с мочой в неизмененном виде. Показана общая поддерживающая терапия и мониторинг жизненно важных функций организма."},{"name":"Применение при беременности и кормлении грудью","value":"Касодекс противопоказан женщинам и не должен назначаться беременным или в период лактации."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"При применении препарата Касодекс может наблюдаться сонливость и головокружение, в связи с чем следует соблюдать осторожность при управлении автотранспортом или иными движущимися механизмами."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003E- Нарушение функции печени;\u003Cbr\u003E- непереносимость лактозы, дефицит лактазы и глюкозо-галактозная мальабсорбция.\u003Cbr\u003EУчитывая возможность замедления выведения бикалутамида и кумуляции бикалутамида у больных с нарушением функции печени, целесообразно периодически оценивать функцию печени. Большинство изменений функции печени встречаются в течение первых шести месяцев лечения препаратом Касодекс.\u003Cbr\u003EВ случае развития выраженных изменений функции печени прием препарата Касодекс необходимо прекратить.\u003Cbr\u003EУ пациентов с прогрессированием заболевания на фоне повышения концентрации простатспецифического антигена (ПСА) необходимо рассмотреть вопрос о прекращении лечения препаратом Касодекс.\u003Cbr\u003EПри назначении препарата Касодекс пациентам, получающим антикоагулянты кумаринового ряда, рекомендуется регулярно контролировать протромбиновое время.\u003Cbr\u003EУчитывая возможность ингибирования препаратом Касодекс активности цитохрома Р450 (изофермента CYP 3А4), следует проявлять осторожность при одновременном применении препарата Касодекс с препаратами, преимущественно метаболизирующимися с участием изофермента CYP 3А4.\u003Cbr\u003EПациентов с непереносимостью лактозы необходимо проинформировать о том, что каждая таблетка препарата Касодекс 150 мг содержит 183 мг моногидрата лактозы.\u003Cbr\u003EРекомендуется регулярно контролировать протромбиновое время при назначении препарата Касодекс пациентам, получающим непрямые антикоагулянты кумаринового ряда."},{"name":"Взаимодействие","value":"Доказательств фармакокинетического или фармакодинамического взаимодействия между препаратом Касодекс и аналогами ГнРГ не получено. \u003Cbr\u003EВ исследованиях in vitro показано, что (R)-энантиомер бикалутамида является ингибитором изофермента CYP 3А4, в меньшей степени влияя на активность изоферментов CYP 2С9, 2С19 и 2D6. В клинических исследованиях с использованием феназона в качестве маркера активности цитохрома Р450 (CYP) не обнаружено потенциальной способности препарата Касодекс к взаимодействию с другими лекарственными препаратами, однако при применении препарата Касодекс в течение 28 дней на фоне приема мидазолама площадь под кривой “концентрация-время” (AUC) мидазолама увеличивалась на 80%.\u003Cbr\u003EПротивопоказано одновременное применение препарата Касодекс с такими препаратами, как терфенадин, астемизол и цизаприд.\u003Cbr\u003EСледует соблюдать осторожность при применении препарата Касодекс одновременно с циклоспорином или блокаторами “медленных” кальциевых каналов. Возможно, потребуется снижение дозы этих препаратов, особенно в случае развития побочных явлений. После начала применения или отмены препарата Касодекс рекомендуется проводить тщательный мониторинг концентрации циклоспорина в плазме и клинического состояния пациента.\u003Cbr\u003EПроявлять осторожность при одновременном применении препарата Касодекс и препаратов, ингибирующих микросомальные ферменты печени, например, с циметидином или кетоконазолом. Одновременное применение может привести к увеличению концентрации бикалутамида в плазме и, возможно, к увеличению частоты возникновения побочных эффектов.\u003Cbr\u003EУсиливает действие непрямых антикоагулянтов кумаринового ряда, в том числе варфарина (конкуренция за связь с белками). Рекомендуется регулярно контролировать протромбиновое время при назначении препарата Касодекс пациентам, получающим непрямые антикоагулянты кумаринового ряда.\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"П N013043/01\nП N013292/01"},{"name":"Дата государственной регистрации","value":"12.07.2018\n17.07.2018"},{"name":"Владелец регистрационного удостоверения","value":"AstraZeneca"},{"name":"Изготовитель","value":"Corden Pharma GmbH"},{"name":"Страна бренда","value":"Великобритания"},{"name":"Страна-производитель","value":"Германия"},{"name":"Название препарата","value":"Касодекс"},{"name":"Срок годности","value":"59 мес."}]}],"transitionId":"tr_5687611429047854011"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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титана диоксид (Е171) 2,3 мг.\u003Cbr\u003E1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивный ингредиент: бикалутамид 50 мг;\u003Cbr\u003Eвспомогательные ингредиенты: лактозы моногидрат 61 мг, карбоксиметилкрахмал натрия 7,5 мг, повидон 5,0 мг, магния стеарат 1,5 мг;\u003Cbr\u003Eсостав оболочки: гипромеллоза 2,5 мг, макрогол 300 0,5 мг, титана диоксид (Е171) 0,77 мг."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Бикалутамид"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Взрослые мужчины (в том числе пожилые):\u003Cbr\u003EПри распространенном раке предстательной железы в комбинации с аналогом ГнРГ или хирургической кастрацией: внутрь по 50 мг один раз в сутки. Лечение препаратом Касодекс необходимо начинать одновременно с началом приема аналога ГнРГ или хирургической кастрацией.\u003Cbr\u003EПри местнораспространенном раке предстательной железы: внутрь по 150 мг один раз в сутки. Касодекс следует принимать длительно, как минимум в течение 2-х лет.\u003Cbr\u003EПри появлении признаков прогрессирования заболевания прием препарата следует прекратить.\u003Cbr\u003EНарушения функции почек: коррекции дозы не требуется.\u003Cbr\u003EНарушения функции печени: при легком нарушении функции печени коррекция дозы не требуется. У пациентов со средним и тяжелым нарушением функции печени может наблюдаться повышенная кумуляция препарата Касодекс."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Касодекс, в целом, обладает хорошей переносимостью, лишь в редких случаях препарат отменяют из-за вызванных побочных эффектов.\u003Cbr\u003EФармакологическое действие бикалутамида может обуславливать следующие побочные эффекты; \u003Cbr\u003E- очень часто (\u003E10%): гинекомастия (может сохраняться даже после прекращения терапии, особенно в случае приема препарата в течение длительного времени), болезненность грудных желез, астения, сыпь. \u003Cbr\u003E- часто (≥1% - \u003C 10%): “приливы” жара, анемия, головокружение, боль в животе, запор, тошнота, периферические отеки, гематурия, гепатотоксичность, транзиторное повышение активности “печеночных” трансаминаз, желтуха (описанные изменения функции печени редко оценивались как серьезные, часто носили транзиторный характер, полностью исчезали или уменьшались при продолжении терапии или после отмены препарата), снижение аппетита, снижение либидо, депрессия, сонливость, диспепсия, метеоризм, алопеция, гирсутизм или восстановление роста волос, сухость кожи, кожный зуд, эректильная дисфункция, боль в груди, увеличение массы тела, инфаркт миокарда (сообщалось о случаях с фатальным исходом), сердечная недостаточность.\u003Cbr\u003E- редко (≥0,1% - \u003C1%): реакции повышенной чувствительности, ангионевротический отек, крапивница, интерстициальные легочные заболевания (сообщалось о случаях с фатальным исходом), реакция фоточувствительности.\u003Cbr\u003E- очень редко (≥0,01% - \u003C0,1 %): печеночная недостаточность (сообщалось о случаях с фатальным исходом)."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Касодекс представляет собой рацемическую смесь с нестероидной антиандрогенной активностью преимущественно (R)-энантиомера, не обладает иной эндокринной активностью. Касодекс связывается с андрогенными рецепторами и, не активируя экспрессию генов, подавляет стимулирующее влияние андрогенов. Результатом этого является регрессия злокачественных новообразований предстательной железы.\u003Cbr\u003EУ некоторых пациентов прекращение приема препарата Касодекс может привести к развитию клинического синдрома \"отмены\" антиандрогенов.\u003Cbr\u003EДля дозировки 150 мг:\u003Cbr\u003EКасодекс представляет собой рацемическую смесь с нестероидной антиандрогенной активностью преимущественно (R)-энантиомера, не обладает иной эндокринной активностью.\u003Cbr\u003EКасодекс связывается с андрогенными рецепторами и, не активируя экспрессию генов, подавляет стимулирующее влияние андрогенов. Результатом этого является регрессия злокачественных новообразований предстательной железы.\u003Cbr\u003EУ некоторых пациентов прекращение приема препарата Касодекс может привести к развитию клинического синдрома “отмены” антиандрогенов.\u003Cbr\u003EПри применении препарата Касодекс в суточной дозе 150 мг ежедневно для лечения пациентов с местнораспространенным (Т3-Т4, любое N, М0 или любое Т, N+, М0) раком предстательной железы, в качестве немедленной гормональной терапии или в качестве адьювантной терапии, значительно снижается риск прогрессирования заболевания и метастазов в кости.\u003Cbr\u003EПри местнораспространенном раке предстательной железы отмечена тенденция к улучшению показателей продолжительности жизни без признаков прогрессирования заболевания в группах пациентов, принимавших Касодекс 150 мг в качестве немедленной терапии или адьювантной терапии, по сравнению со стандартной терапией (хирургическое лечение, лучевая терапия).\u003Cbr\u003EПоказано увеличение продолжительности жизни среди пациентов с местнораспространенным раком предстательной железы, получавших Касодекс в дозе 150 мг в качестве немедленной монотерапии и в качестве адъювантного лечения в комбинации с лучевой терапией.\u003Cbr\u003EПрименение препарата Касодекс в дозе 150 мг по сравнению с хирургической кастрацией у пациентов с местнораспространенным неметастатическим раком предстательной железы не выявило статистически достоверного различия в продолжительности жизни и времени до прогрессирования при статистически достоверном преимуществе сексуальной функции и физического состояния.\u003Cbr\u003E"},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"противоопухолевые средства"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":14805991,"name":"Пол"}],"isMainProperty":false,"name":"Пол","value":"для мужчин"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 30°C."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Случай передозировки у человека не описаны.\u003Cbr\u003EСпецифического антидота не существует.\u003Cbr\u003EЛечение симптоматическое. Проведение диализа неэффективно, так как бикалутамид прочно связывается с белками и не выводится с мочой в неизмененном виде. Показана общая поддерживающая терапия и мониторинг жизненно важных функций организма."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Касодекс противопоказан женщинам и не должен назначаться беременным или в период лактации."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"При применении препарата Касодекс может наблюдаться сонливость и головокружение, в связи с чем следует соблюдать осторожность при управлении автотранспортом или иными движущимися механизмами."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003E- Нарушение функции печени;\u003Cbr\u003E- непереносимость лактозы, дефицит лактазы и глюкозо-галактозная мальабсорбция.\u003Cbr\u003EУчитывая возможность замедления выведения бикалутамида и кумуляции бикалутамида у больных с нарушением функции печени, целесообразно периодически оценивать функцию печени. Большинство изменений функции печени встречаются в течение первых шести месяцев лечения препаратом Касодекс.\u003Cbr\u003EВ случае развития выраженных изменений функции печени прием препарата Касодекс необходимо прекратить.\u003Cbr\u003EУ пациентов с прогрессированием заболевания на фоне повышения концентрации простатспецифического антигена (ПСА) необходимо рассмотреть вопрос о прекращении лечения препаратом Касодекс.\u003Cbr\u003EПри назначении препарата Касодекс пациентам, получающим антикоагулянты кумаринового ряда, рекомендуется регулярно контролировать протромбиновое время.\u003Cbr\u003EУчитывая возможность ингибирования препаратом Касодекс активности цитохрома Р450 (изофермента CYP 3А4), следует проявлять осторожность при одновременном применении препарата Касодекс с препаратами, преимущественно метаболизирующимися с участием изофермента CYP 3А4.\u003Cbr\u003EПациентов с непереносимостью лактозы необходимо проинформировать о том, что каждая таблетка препарата Касодекс 150 мг содержит 183 мг моногидрата лактозы.\u003Cbr\u003EРекомендуется регулярно контролировать протромбиновое время при назначении препарата Касодекс пациентам, получающим непрямые антикоагулянты кумаринового ряда."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Доказательств фармакокинетического или фармакодинамического взаимодействия между препаратом Касодекс и аналогами ГнРГ не получено. \u003Cbr\u003EВ исследованиях in vitro показано, что (R)-энантиомер бикалутамида является ингибитором изофермента CYP 3А4, в меньшей степени влияя на активность изоферментов CYP 2С9, 2С19 и 2D6. В клинических исследованиях с использованием феназона в качестве маркера активности цитохрома Р450 (CYP) не обнаружено потенциальной способности препарата Касодекс к взаимодействию с другими лекарственными препаратами, однако при применении препарата Касодекс в течение 28 дней на фоне приема мидазолама площадь под кривой “концентрация-время” (AUC) мидазолама увеличивалась на 80%.\u003Cbr\u003EПротивопоказано одновременное применение препарата Касодекс с такими препаратами, как терфенадин, астемизол и цизаприд.\u003Cbr\u003EСледует соблюдать осторожность при применении препарата Касодекс одновременно с циклоспорином или блокаторами “медленных” кальциевых каналов. Возможно, потребуется снижение дозы этих препаратов, особенно в случае развития побочных явлений. После начала применения или отмены препарата Касодекс рекомендуется проводить тщательный мониторинг концентрации циклоспорина в плазме и клинического состояния пациента.\u003Cbr\u003EПроявлять осторожность при одновременном применении препарата Касодекс и препаратов, ингибирующих микросомальные ферменты печени, например, с циметидином или кетоконазолом. Одновременное применение может привести к увеличению концентрации бикалутамида в плазме и, возможно, к увеличению частоты возникновения побочных эффектов.\u003Cbr\u003EУсиливает действие непрямых антикоагулянтов кумаринового ряда, в том числе варфарина (конкуренция за связь с белками). 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    Рейтинг товара: 5 из 5
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    Цена 312 ₽
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  • Бусерелин-депо лиоф. д/приг. сусп. для в/м введ. пролонг. действ., 3.75 мг, 1 шт.
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    Бусерелин-депо лиоф. д/приг. сусп. для в/м введ. пролонг. действ., 3.75 мг, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 4 061 ₽
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  • Методжект р-р для п/к введ. шприц, 50 мг/мл, 0.2 мл, 1 шт.
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    Методжект р-р для п/к введ. шприц, 50 мг/мл, 0.2 мл, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 10 оценок
    Цена 748 ₽
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  • Абакавир Канон таб. п/о плен., 300 мг, 60 шт.
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    Абакавир Канон таб. п/о плен., 300 мг, 60 шт.

    Цена 3 602 ₽
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  • Лефлуномид таб. п/о плен., 20 мг, 30 шт.
    –21 %
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    Лефлуномид таб. п/о плен., 20 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 8 оценок
    Цена 899 ₽ вместо 1 137
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  • Лорета таб. п/о плен., 2.5 мг, 30 шт.
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    Лорета таб. п/о плен., 2.5 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 1 449 ₽
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  • Кивекса таб. п/о плен., 600 мг+300 мг, 30 шт.
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    Кивекса таб. п/о плен., 600 мг+300 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 3 467 ₽
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Инструкция

Показания к применению

- Касодекс в дозе 50 мг в комбинации с аналогом ГнРГ (гонадотропин-рилизинг гормон) или хирургической кастрацией показан для лечения распространенного рака предстательной железы;
- Касодекс в дозе 150 мг показан для лечения местнораспространенного рака предстательной железы (Т3-Т4, любая N, М0; Т1-Т2, N+, М0) в качестве монотерапии или адъювантной терапии в сочетании с радикальной простатэктомией или радиотерапией;
- Касодекс в дозе 150 мг также показан для лечения местнораспространенного, неметастатического рака предстательной железы в случаях, когда хирургическая кастрация или другие медицинские вмешательства неприемлемы или не подходят пациенту

Противопоказания

- Повышенная чувствительность к бикалутамиду или другим компонентам препарата;
- одновременный прием с терфенадином, астемизолом и цизапридом;
- Касодекс не должен назначаться детям и женщинам.

Способ применения и дозы

Взрослые мужчины (в том числе пожилые):
При распространенном раке предстательной железы в комбинации с аналогом ГнРГ или хирургической кастрацией: внутрь по 50 мг один раз в сутки. Лечение препаратом Касодекс необходимо начинать одновременно с началом приема аналога ГнРГ или хирургической кастрацией.
При местнораспространенном раке предстательной железы: внутрь по 150 мг один раз в сутки. Касодекс следует принимать длительно, как минимум в течение 2-х лет.
При появлении признаков прогрессирования заболевания прием препарата следует прекратить.
Нарушения функции почек: коррекции дозы не требуется.
Нарушения функции печени: при легком нарушении функции печени коррекция дозы не требуется. У пациентов со средним и тяжелым нарушением функции печени может наблюдаться повышенная кумуляция препарата Касодекс.
Полная инструкция
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Касодекс таб. п/о плен.
Касодекс таб. п/о плен., 50 мг, 28 шт.
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    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 166 ₽ вместо 190
  • Золадекс капс. для п/к введ. пролонг. действ. шприц-аппликатор, 3.6 мг, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:186939279_2/content/content/toggleWishlist":{"skuId":"101333037763","productId":186939279,"offerId":"qgJQPEYgQ-JOIY-ARZtT4w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgt7e9NOz8v0kEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCI/vkVkQw+Wtv/kCGI/d0Acg8tzBBw==","sign":"jUYDajticWcfENlKJ6li5eEQ9vlW5NDPSSWldyKpsO4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:186939279_2/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Золадекс капс. для п/к введ. пролонг. действ. шприц-аппликатор, 3.6 мг, 1 шт.

    Цена 4 107 ₽
  • Метотрексат таб. п/о, 2.5 мг, 50 шт.
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    Метотрексат таб. п/о, 2.5 мг, 50 шт.

    Цена 312 ₽
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 684 ₽ вместо 1 890
  • Бусерелин-депо лиоф. д/приг. сусп. для в/м введ. пролонг. действ., 3.75 мг, 1 шт.
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    Бусерелин-депо лиоф. д/приг. сусп. для в/м введ. пролонг. действ., 3.75 мг, 1 шт.

    Цена 4 061 ₽
  • Методжект р-р для п/к введ. шприц, 50 мг/мл, 0.2 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:460219255_6/content/content/gallery":{"title":"Методжект р-р для п/к введ. шприц, 50 мг/мл, 0.2 мл, 1 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5229883/img_id259149262328716717.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5229883/img_id259149262328716717.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5229883/img_id259149262328716717.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5229883/img_id259149262328716717.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5229883/img_id259149262328716717.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5229883/img_id259149262328716717.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1767151/img_id1749807223798047373.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1767151/img_id1749807223798047373.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1767151/img_id1749807223798047373.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1767151/img_id1749807223798047373.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1767151/img_id1749807223798047373.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1767151/img_id1749807223798047373.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgt7e9NOz8v0kEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCPfGudsBELzE18D5AhjewdUHIPLcwQc=","sign":"2l98lTVkmDWyqGL4aGcvpx0OMHKXImmWJ3XjseLNZW8="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:460219255_6/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Методжект р-р для п/к введ. шприц, 50 мг/мл, 0.2 мл, 1 шт.

    Цена 748 ₽
  • Абакавир Канон таб. п/о плен., 300 мг, 60 шт.
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    Абакавир Канон таб. п/о плен., 300 мг, 60 шт.

    Цена 3 602 ₽
  • Реклама
    {"widgets":{"@light/AdLabel":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content/adLabel":{"adLabel":{"adLabelText":"Реклама","advertizer":"АКЦИОНЕРНОЕ ОБЩЕСТВО \"АЛЬФА-БАНК\", ИНН 7728168971, ID #e-1g-105699-VND-ADV","adLabel":1},"advertisementId":1961521,"allowDebug":false,"borderRadius":5,"indents":6}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content/adLabel":{"name":"@light/AdLabel"}}}
    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  • Лефлуномид таб. п/о плен., 20 мг, 30 шт.
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    Лефлуномид таб. п/о плен., 20 мг, 30 шт.

    Цена 899 ₽ вместо 1 137
  • Таблетница на 7 дней 3 приема черная
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    Таблетница на 7 дней 3 приема черная

    Цена 733 ₽ вместо 1 000
  • Контейнер для хранения/таблетница/кейс для таблеток
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    Контейнер для хранения/таблетница/кейс для таблеток

    Цена 372 ₽ вместо 699
  • Лорета таб. п/о плен., 2.5 мг, 30 шт.
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    Лорета таб. п/о плен., 2.5 мг, 30 шт.

    Цена 1 449 ₽
  • Кивекса таб. п/о плен., 600 мг+300 мг, 30 шт.
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    Кивекса таб. п/о плен., 600 мг+300 мг, 30 шт.

    Цена 3 467 ₽
  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (белого цвета)
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    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (белого цвета)

    Цена 264 ₽ вместо 380
  • Таблетница на 7 дней/контейнер для таблеток и витаминов на 7 дней, Immunit
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    Таблетница на 7 дней/контейнер для таблеток и витаминов на 7 дней, Immunit

    Цена 149 ₽ вместо 189
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 166 ₽ вместо 400
  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 202 ₽ вместо 350
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