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Описание

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Клиндовит Комбо гель д/нар.прим, 50 мг+10 мг/г, 15 г

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4.8
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Коротко о товаре

Артикул Маркета
4453223993
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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\u003Cbr\u003E- детский возраст до 12 лет; \u003Cbr\u003E- период грудного вскармливания; \u003Cbr\u003E- болезнь Крона, язвенный колит, псевдомембранозный колит, в том числе в анамнезе."},{"name":"Состав","value":"1 г геля содержит: \u003Cbr\u003Eдействующие вещества: бензоила пероксид водный 77% (в пересчете на бензоила пероксид безводный) - 64,9 мг (50,0 мг), клиндамицина фосфат (в пересчете на клиндамицин) - 11,9 мг (10,0 мг); \u003Cbr\u003Eвспомогательные вещества карбомер (Карбопол 980), диметикон, динатрия лаурил сульфосукцинат, натрия гидроксид, динатрия эдетат, кремния диоксид коллоидный гидратированный, глицерол, полоксамер 182, вода очищенная."},{"name":"Действующее вещество","value":"Бензоила пероксид+Клиндамицин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["27144131:36090458"]}}},{"name":"Способ применения и дозы","value":"Препарат Клиндовит Комбо предназначен только для наружного применения. \u003Cbr\u003EПрепарат следует наносить тонким слоем на всю поражённую область 1 раз в день после тщательного очищения кожи очищающим средством мягкого действия и полного высыхания кожи. \u003Cbr\u003EГель плохо впитывается в случае нанесения на кожу чрезмерного количества препарата. \u003Cbr\u003EПосле нанесения геля следует вымыть руки. \u003Cbr\u003EПри необходимости после впитывания геля можно использовать увлажняющее средство. \u003Cbr\u003EПри возникновении сухости кожи или шелушения следует сократить частоту применения геля либо временно приостановить лечение. \u003Cbr\u003EЭффективность препарата при частоте применения реже 1 раза в день не была изучена. \u003Cbr\u003EБолее частое, чем рекомендуется инструкцией, нанесение геля не повышает эффективность лечения, но может повысить риск возникновения раздражения кожи. \u003Cbr\u003EДлительность курса лечения, необходимая для достижения терапевтического эффекта, составляет от 2 до 5 недель, но не более 12 недель. \u003Cbr\u003EБезопасность и эффективность применения комбинации клиндамицина и бензоила пероксида при лечении акне длительностью более 12 недель не были изучены. Следует тщательно оценить ожидаемую пользу для пациента при назначении лечения длительностью более 12 недель непрерывного использования. \u003Cbr\u003EОсобые группы пациентов \u003Cbr\u003EДети \u003Cbr\u003EБезопасность и эффективность применения комбинации клиндамицина и бензоила пероксида не были изучены для детей младше 12 лет, поэтому в данной популяции использование комбинации клиндамицина и бензоила пероксида не рекомендуется. \u003Cbr\u003EПациенты пожилого возраста \u003Cbr\u003EСпециальные рекомендации для пожилых пациентов отсутствуют. \u003Cbr\u003EПациенты с почечной недостаточностью \u003Cbr\u003EНеобходимость в коррекции дозы отсутствует. \u003Cbr\u003EПоскольку абсорбция клиндамицина и бензоила пероксида через кожу при наружном применении является слабой, маловероятно влияние почечной недостаточности на возникновение клинически значимого системного воздействия. \u003Cbr\u003EПациенты с печеночной недостаточностью \u003Cbr\u003EНеобходимость в коррекции дозы отсутствует. \u003Cbr\u003EПоскольку абсорбция клиндамицина и бензоила пероксида через кожу при наружном применении является слабой, маловероятно влияние печеночной недостаточности на возникновение клинически значимого системного воздействия."},{"name":"Побочные действия","value":"Нежелательные явления, представленные ниже, перечислены в соответствии с поражением органов и систем органов и частотой встречаемости. Частота встречаемости определяется следующим образом: очень часто (≥1/10), часто (≥1/100 и \u003C1/10), нечасто (≥1/1000 и \u003C1/100), редко (≥1/10000 и \u003C1/1000), очень редко (\u003C1/10000, включая отдельные случаи). Категории частоты были сформированы на основании клинических исследований препарата и пострегистрационного наблюдения. \u003Cbr\u003EЧастота встречаемости нежелательных явлений \u003Cbr\u003EНарушения со стороны иммунной системы \u003Cbr\u003EРедко: аллергические реакции, включая гиперчувствительность и анафилактические реакции. \u003Cbr\u003EНарушения со стороны нервной системы \u003Cbr\u003EНечасто: парестезия в области нанесения препарата. \u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта \u003Cbr\u003EРедко: колит (включая псевдомембранозный колит), геморрагическая диарея, диарея, боль в животе. \u003Cbr\u003EНарушения со стороны кожи и подкожных тканей \u003Cbr\u003EОчень часто: чувство жжения, эритема, шелушение, сухость кожи в области нанесения препарата (данные явления в основном слабо выражены). \u003Cbr\u003EЧасто: фотосенсибилизация в области нанесения препарата. \u003Cbr\u003EНечасто: зуд, эритематозная сыпь, дерматит, усугубление акне в области нанесения препарата. \u003Cbr\u003EРедко: крапивница в области нанесения препарата. \u003Cbr\u003EОбщие расстройства и нарушения в области нанесения \u003Cbr\u003EРедко: другие реакции в области нанесения, включая обесцвечивание волос. \u003Cbr\u003EВ исследованиях при местном применении клиндамицина в качестве монотерапии также часто отмечались головная боль и боль в области нанесения препарата."},{"name":"Фармакологическое действие","value":"Клиндамицин является антибиотиком группы линкозамидов, обладающим бактериостатическим действием против грамположительных аэробных микроорганизмов и широкого спектра анаэробных бактерий. Линкозамиды, такие как клиндамицин, связываются с 50S субъединицей рибосом восприимчивых бактерий и, препятствуя транспорту пептидила, предотвращают удлинение пептидных цепей. Действие клиндамицина является в основном бактериостатическим, тем не менее, высокие концентрации могут оказывать медленное бактерицидное воздействие в отношении чувствительных штаммов. \u003Cbr\u003EХотя клиндамицина фосфат является неактивным in vitro, быстрый гидролиз in vivo преобразовывает это соединение в активный клиндамицин. \u003Cbr\u003EБензоила пероксид является высоколипофильным окислителем с бактерицидным и слабым кератолитическим действием. Бензоила пероксид обладает неспецифическим бактерицидным механизмом действия, образуя активные формы кислорода, которые препятствуют появлению резистентных к клиндамицину микроорганизмов. \u003Cbr\u003EФармакодинамические эффекты \u003Cbr\u003EКлиндамицин активен in vitro в отношении Propionibacterium acnes, которые вызывают акне. Существуют данные о возможности развития резистентности Р. acnes к клиндамицину. \u003Cbr\u003EКлиндамицин ингибирует Р. acnes in vitro (минимальная ингибирующая концентрация (МИК) 0,4 мкг/мл). \u003Cbr\u003EПосле нанесения клиндамицин снижает содержание свободных жирных кислот на поверхности кожи приблизительно с 14% до 2%. \u003Cbr\u003EКлиндамицин уменьшает воспаление путем ингибирования хемотаксиса лейкоцитов. Эффективность бензоила пероксида в лечении акне в основном объясняется его бактерицидной активностью, особенно в отношении Р. acnes. Бактерицидная активность бензоила пероксида вызвана высвобождением активных или свободных кислородных радикалов, способных окислять бактериальные белки. Бензоила пероксид эффективен при лечении акне благодаря противовоспалительному и некоторому кератолитическому действию. \u003Cbr\u003EРезистентность и перекрёстная резистентность \u003Cbr\u003EЛечение акне такими антибиотиками, как клиндамицин и эритромицин для местного и перорального применения, в форме монотерапии было связано с развитием антимикробной резистентности у Р. acnes, а также у сапрофитной флоры (например, Staphylococcus aureus, Streptococcus pyogenes). Длительное использование клиндамицина может вызвать развитие резистентности у этих микроорганизмов. \u003Cbr\u003EБензоила пероксид обладает бактерицидным эффектом, и он не вызывал резистентности у Р. acnes. Включение бензоила пероксида в состав комбинированного препарата, содержащего 1% клиндамицина и 5% бензоила пероксида, снижало количество резистентных к клиндамицину организмов Р. acnes. \u003Cbr\u003EУровень приобретенной резистентности для конкретных организмов может варьироваться в зависимости от географического положения и времени. \u003Cbr\u003EЕсли это возможно, следует учитывать местные данные о резистентности, в особенности при лечении серьезных инфекций. \u003Cbr\u003EБыло установлено наличие перекрёстной резистентности между клиндамицином и линкомицином."},{"name":"Фармакологическая группа","value":"средство лечения угревой сыпи"},{"name":"Форма выпуска","value":"гель"},{"name":"Способ применения/введения","value":"наружный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["35947170:36763741"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 8 °С. Не замораживать. \u003Cbr\u003EПосле вскрытия тубы: \u003Cbr\u003EХранить при температуре не выше 25 °С. Не замораживать. \u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы \u003Cbr\u003EНанесение чрезмерного количества препарата может вызывать сильное раздражение. В таких случаях прекращают применение препарата до исчезновения признаков раздражения кожи. При местном применении бензоила пероксид в основном абсорбируется в количестве, недостаточном для возникновения системных эффектов. При местном применении чрезмерного количества клиндамицина может произойти его абсорбция в количестве, способном вызвать системные эффекты. При случайном попадании комбинации клиндамицина и бензоила пероксида внутрь могут возникать нежелательные реакции со стороны желудочно-кишечного тракта, схожие с нежелательными реакциями, возникающими при парентеральном применении клиндамицина. \u003Cbr\u003EЛечение \u003Cbr\u003EПрименяют соответствующее симптоматическое лечение для облегчения раздражения, вызванного нанесением чрезмерного количества препарата. Лечение при случайном попадании препарата внутрь следует проводить, исходя из клинической ситуации, либо в соответствии с рекомендациями местного Национального токсикологического центра при наличии таковых."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность \u003Cbr\u003EКонтролируемых исследований с участием беременных женщин, которые используют гель для наружного применения, содержащий комбинацию клиндамицина и бензоила пероксида, проведено не было. \u003Cbr\u003EДанные по использованию препаратов для наружного применения, содержащих одно из действующих веществ (клиндамицин или бензоила пероксид), у беременных женщин ограничены. Доклинические исследования не подтверждают прямого либо косвенного нежелательного воздействия, которое может быть отнесено к репродуктивной токсичности. \u003Cbr\u003EУчитывая низкий уровень системного воздействия клиндамицина и бензоила пероксида, нежелательное воздействие на развитие беременности является маловероятным. \u003Cbr\u003EТем не менее, комбинацию клиндамицина и бензоила пероксида следует назначать во время беременности только в случае, если ожидаемая польза для матери превышает потенциальный риск для плода. \u003Cbr\u003EГрудное вскармливание \u003Cbr\u003EНет данных о безопасности местного применения комбинации клиндамицина и бензоила пероксида в период кормления грудью. \u003Cbr\u003EКлиндамицин и бензоила пероксид обладают слабой чрескожной абсорбцией, однако данные об экскреции клиндамицина или бензоила пероксида при наружном применении в грудное молоко отсутствуют. Клиндамицин экскретируется в грудное молоко при пероральном и парентеральном применении. \u003Cbr\u003EКомбинацию клиндамицина и бензоила пероксида следует использовать в период лактации только в том случае, если ожидаемая польза для матери превышает потенциальный риск для ребенка. \u003Cbr\u003EВо избежание случайного попадания препарата в организм ребенка при его применении в период лактации препарат не следует наносить на кожу груди."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Негативное влияние препарата на способность управлять транспортными средствами или механизмами является маловероятным."},{"name":"Особые указания","value":"Следует избегать попадания препарата в рот, глаза, на поверхность губ, другие слизистые оболочки, а также на раздраженные поврежденные области кожи. При случайном попадании геля на указанные участки их следует хорошо промыть водой. \u003Cbr\u003EВо время первой недели лечения у большинства пациентов усиливается шелушение и покраснение кожи. В зависимости от тяжести данных побочных эффектов пациенты могут использовать увлажняющие средства, временно снизить частоту применения препарата либо временно прекратить применение. Эффективность препарата при применении с частотой реже одного раза в день не изучалась. \u003Cbr\u003EПри возникновении сильного раздражения кожи (например, сильная эритема, сильная сухость кожи и зуд, сильное покалывание/жжение) применение препарата следует прекратить. \u003Cbr\u003EПоскольку бензоила пероксид может вызывать повышенную чувствительность к солнечному свету, следует избегать длительного воздействия солнечных лучей, а также не посещать солярий в период применения препарата. В случае, если пребывания на солнце нельзя избежать, следует использовать солнцезащитные косметические средства для кожи и одежду, защищающую от солнечных лучей. \u003Cbr\u003EПри наличии у пациента солнечных ожогов следует прекратить применение препарата до излечения ожогов. \u003Cbr\u003EПрепарат способен обесцветить волосы и цветную ткань. Следует избегать попадания препарата на волосы, ткань, мебель или ковровое покрытие. \u003Cbr\u003EПсевдомембранозный колит \u003Cbr\u003EСлучаи псевдомембранозного колита были отмечены при использовании практически всех антибактериальных средств, включая клиндамицин. Степень их выраженности варьирует по тяжести от слабой до опасной для жизни. Псевдомембранозный колит может возникнуть через несколько недель после прекращения терапии. \u003Cbr\u003EНесмотря на то, что возникновение псевдомембранозного колита маловероятно при наружном применении комбинации клиндамицина и бензоила пероксида, в случае возникновения длительной или серьезной диареи либо если пациент страдает коликами в животе, лечение следует немедленно прекратить и обратиться к врачу, поскольку симптомы могут означать присутствие колита, вызванного приемом антибиотика. \u003Cbr\u003EРезистентность к клиндамицину \u003Cbr\u003EБензоила пероксид снижает вероятность появления микроорганизмов, резистентных к клиндамицину. Тем не менее, у пациентов, недавно использовавших клиндамицин или эритромицин для парентерального или наружного применения, более вероятно наличие пропионибактерий и сапрофитной флоры с ранее приобретенной антимикробной резистентностью. \u003Cbr\u003EПерекрёстная резистентность \u003Cbr\u003EБыло установлено наличие перекрёстной резистентности между клиндамицином и линкомицином. Резистентность к клиндамицину часто связана с резистентностью к эритромицину. \u003Cbr\u003EС осторожностью:Одновременное применение с другими местными средствами лечения акне следует проводить с осторожностью по причине возможного возникновения кумулятивного раздражения кожи, которое иногда может быть тяжелым, в особенности при применении средств с отшелушивающим либо абразивным действием. \u003Cbr\u003EПрепарат Клиндовит Комбо следует применять с осторожностью при необходимости одновременного приема с миорелаксантами периферического действия. \u003Cbr\u003EПрепарат Клиндовит Комбо следует применять с осторожностью у пациентов с атопией в связи с возможным усилением сухости кожи."},{"name":"Взаимодействие","value":"Так как клиндамицин проявляет антагонизм с эритромицином, препарат Клиндовит Комбо не следует использовать в комбинации с препаратами, содержащими эритромицин. Установлено, что клиндамицин нарушает нейромышечную передачу и, следовательно, может усиливать действие миорелаксантов периферического действия. \u003Cbr\u003EСледует избегать совместного применения комбинации клиндамицина и бензоила пероксида с третиноином, изотретиноином и тазаротеном, поскольку бензоила пероксид способен снижать их эффективность и усиливать раздражение кожи. При необходимости комбинированного лечения препараты следует применять в разное время дня (например, один препарат утром и другой препарат вечером). \u003Cbr\u003EИспользование препаратов для местного применения, содержащих бензоила пероксид, одновременно с препаратами для местного применения, содержащими сульфонамид, может вызывать временное изменение цвета кожи и волос в месте нанесения препарата (окраска в желтый или оранжевый цвет)."},{"name":"Регистрационный номер","value":"ЛП-№(000122)-(РГ-RU)"},{"name":"Дата государственной регистрации","value":"19.07.2022"},{"name":"Владелец регистрационного удостоверения","value":"АКРИХИН","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["34324371:35649313","7893318:11037214"]}}},{"name":"Изготовитель","value":"Фармаприм"},{"name":"Фасовщик","value":"Фармаприм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Республика Молдова"},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"11107181623722321766":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кожа"},{"name":"Назначение","value":"лечение андрогензависимых форм акне"},{"name":"Показания к применению","value":"Акне (acne vulgaris) легкой и умеренной степени тяжести, особенно с преобладанием воспалительных поражений кожи."},{"name":"Противопоказания","value":"- Повышенная чувствительность к клиндамицину, линкомицину, бензоила пероксиду и/или к любому из компонентов препарата; \u003Cbr\u003E- детский возраст до 12 лет; \u003Cbr\u003E- период грудного вскармливания; \u003Cbr\u003E- болезнь Крона, язвенный колит, псевдомембранозный колит, в том числе в анамнезе."},{"name":"Состав","value":"1 г геля содержит: \u003Cbr\u003Eдействующие вещества: бензоила пероксид водный 77% (в пересчете на бензоила пероксид безводный) - 64,9 мг (50,0 мг), клиндамицина фосфат (в пересчете на клиндамицин) - 11,9 мг (10,0 мг); \u003Cbr\u003Eвспомогательные вещества карбомер (Карбопол 980), диметикон, динатрия лаурил сульфосукцинат, натрия гидроксид, динатрия эдетат, кремния диоксид коллоидный гидратированный, глицерол, полоксамер 182, вода очищенная."},{"name":"Действующее вещество","value":"Бензоила пероксид+Клиндамицин"},{"name":"Способ применения и дозы","value":"Препарат Клиндовит Комбо предназначен только для наружного применения. \u003Cbr\u003EПрепарат следует наносить тонким слоем на всю поражённую область 1 раз в день после тщательного очищения кожи очищающим средством мягкого действия и полного высыхания кожи. \u003Cbr\u003EГель плохо впитывается в случае нанесения на кожу чрезмерного количества препарата. \u003Cbr\u003EПосле нанесения геля следует вымыть руки. \u003Cbr\u003EПри необходимости после впитывания геля можно использовать увлажняющее средство. \u003Cbr\u003EПри возникновении сухости кожи или шелушения следует сократить частоту применения геля либо временно приостановить лечение. \u003Cbr\u003EЭффективность препарата при частоте применения реже 1 раза в день не была изучена. \u003Cbr\u003EБолее частое, чем рекомендуется инструкцией, нанесение геля не повышает эффективность лечения, но может повысить риск возникновения раздражения кожи. \u003Cbr\u003EДлительность курса лечения, необходимая для достижения терапевтического эффекта, составляет от 2 до 5 недель, но не более 12 недель. \u003Cbr\u003EБезопасность и эффективность применения комбинации клиндамицина и бензоила пероксида при лечении акне длительностью более 12 недель не были изучены. Следует тщательно оценить ожидаемую пользу для пациента при назначении лечения длительностью более 12 недель непрерывного использования. \u003Cbr\u003EОсобые группы пациентов \u003Cbr\u003EДети \u003Cbr\u003EБезопасность и эффективность применения комбинации клиндамицина и бензоила пероксида не были изучены для детей младше 12 лет, поэтому в данной популяции использование комбинации клиндамицина и бензоила пероксида не рекомендуется. \u003Cbr\u003EПациенты пожилого возраста \u003Cbr\u003EСпециальные рекомендации для пожилых пациентов отсутствуют. \u003Cbr\u003EПациенты с почечной недостаточностью \u003Cbr\u003EНеобходимость в коррекции дозы отсутствует. \u003Cbr\u003EПоскольку абсорбция клиндамицина и бензоила пероксида через кожу при наружном применении является слабой, маловероятно влияние почечной недостаточности на возникновение клинически значимого системного воздействия. \u003Cbr\u003EПациенты с печеночной недостаточностью \u003Cbr\u003EНеобходимость в коррекции дозы отсутствует. \u003Cbr\u003EПоскольку абсорбция клиндамицина и бензоила пероксида через кожу при наружном применении является слабой, маловероятно влияние печеночной недостаточности на возникновение клинически значимого системного воздействия."},{"name":"Побочные действия","value":"Нежелательные явления, представленные ниже, перечислены в соответствии с поражением органов и систем органов и частотой встречаемости. Частота встречаемости определяется следующим образом: очень часто (≥1/10), часто (≥1/100 и \u003C1/10), нечасто (≥1/1000 и \u003C1/100), редко (≥1/10000 и \u003C1/1000), очень редко (\u003C1/10000, включая отдельные случаи). Категории частоты были сформированы на основании клинических исследований препарата и пострегистрационного наблюдения. \u003Cbr\u003EЧастота встречаемости нежелательных явлений \u003Cbr\u003EНарушения со стороны иммунной системы \u003Cbr\u003EРедко: аллергические реакции, включая гиперчувствительность и анафилактические реакции. \u003Cbr\u003EНарушения со стороны нервной системы \u003Cbr\u003EНечасто: парестезия в области нанесения препарата. \u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта \u003Cbr\u003EРедко: колит (включая псевдомембранозный колит), геморрагическая диарея, диарея, боль в животе. \u003Cbr\u003EНарушения со стороны кожи и подкожных тканей \u003Cbr\u003EОчень часто: чувство жжения, эритема, шелушение, сухость кожи в области нанесения препарата (данные явления в основном слабо выражены). \u003Cbr\u003EЧасто: фотосенсибилизация в области нанесения препарата. \u003Cbr\u003EНечасто: зуд, эритематозная сыпь, дерматит, усугубление акне в области нанесения препарата. \u003Cbr\u003EРедко: крапивница в области нанесения препарата. \u003Cbr\u003EОбщие расстройства и нарушения в области нанесения \u003Cbr\u003EРедко: другие реакции в области нанесения, включая обесцвечивание волос. \u003Cbr\u003EВ исследованиях при местном применении клиндамицина в качестве монотерапии также часто отмечались головная боль и боль в области нанесения препарата."},{"name":"Фармакологическое действие","value":"Клиндамицин является антибиотиком группы линкозамидов, обладающим бактериостатическим действием против грамположительных аэробных микроорганизмов и широкого спектра анаэробных бактерий. Линкозамиды, такие как клиндамицин, связываются с 50S субъединицей рибосом восприимчивых бактерий и, препятствуя транспорту пептидила, предотвращают удлинение пептидных цепей. Действие клиндамицина является в основном бактериостатическим, тем не менее, высокие концентрации могут оказывать медленное бактерицидное воздействие в отношении чувствительных штаммов. \u003Cbr\u003EХотя клиндамицина фосфат является неактивным in vitro, быстрый гидролиз in vivo преобразовывает это соединение в активный клиндамицин. \u003Cbr\u003EБензоила пероксид является высоколипофильным окислителем с бактерицидным и слабым кератолитическим действием. Бензоила пероксид обладает неспецифическим бактерицидным механизмом действия, образуя активные формы кислорода, которые препятствуют появлению резистентных к клиндамицину микроорганизмов. \u003Cbr\u003EФармакодинамические эффекты \u003Cbr\u003EКлиндамицин активен in vitro в отношении Propionibacterium acnes, которые вызывают акне. Существуют данные о возможности развития резистентности Р. acnes к клиндамицину. \u003Cbr\u003EКлиндамицин ингибирует Р. acnes in vitro (минимальная ингибирующая концентрация (МИК) 0,4 мкг/мл). \u003Cbr\u003EПосле нанесения клиндамицин снижает содержание свободных жирных кислот на поверхности кожи приблизительно с 14% до 2%. \u003Cbr\u003EКлиндамицин уменьшает воспаление путем ингибирования хемотаксиса лейкоцитов. Эффективность бензоила пероксида в лечении акне в основном объясняется его бактерицидной активностью, особенно в отношении Р. acnes. Бактерицидная активность бензоила пероксида вызвана высвобождением активных или свободных кислородных радикалов, способных окислять бактериальные белки. Бензоила пероксид эффективен при лечении акне благодаря противовоспалительному и некоторому кератолитическому действию. \u003Cbr\u003EРезистентность и перекрёстная резистентность \u003Cbr\u003EЛечение акне такими антибиотиками, как клиндамицин и эритромицин для местного и перорального применения, в форме монотерапии было связано с развитием антимикробной резистентности у Р. acnes, а также у сапрофитной флоры (например, Staphylococcus aureus, Streptococcus pyogenes). Длительное использование клиндамицина может вызвать развитие резистентности у этих микроорганизмов. \u003Cbr\u003EБензоила пероксид обладает бактерицидным эффектом, и он не вызывал резистентности у Р. acnes. Включение бензоила пероксида в состав комбинированного препарата, содержащего 1% клиндамицина и 5% бензоила пероксида, снижало количество резистентных к клиндамицину организмов Р. acnes. \u003Cbr\u003EУровень приобретенной резистентности для конкретных организмов может варьироваться в зависимости от географического положения и времени. \u003Cbr\u003EЕсли это возможно, следует учитывать местные данные о резистентности, в особенности при лечении серьезных инфекций. \u003Cbr\u003EБыло установлено наличие перекрёстной резистентности между клиндамицином и линкомицином."},{"name":"Фармакологическая группа","value":"средство лечения угревой сыпи"},{"name":"Форма выпуска","value":"гель"},{"name":"Способ применения/введения","value":"наружный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 8 °С. Не замораживать. \u003Cbr\u003EПосле вскрытия тубы: \u003Cbr\u003EХранить при температуре не выше 25 °С. Не замораживать. \u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы \u003Cbr\u003EНанесение чрезмерного количества препарата может вызывать сильное раздражение. В таких случаях прекращают применение препарата до исчезновения признаков раздражения кожи. При местном применении бензоила пероксид в основном абсорбируется в количестве, недостаточном для возникновения системных эффектов. При местном применении чрезмерного количества клиндамицина может произойти его абсорбция в количестве, способном вызвать системные эффекты. При случайном попадании комбинации клиндамицина и бензоила пероксида внутрь могут возникать нежелательные реакции со стороны желудочно-кишечного тракта, схожие с нежелательными реакциями, возникающими при парентеральном применении клиндамицина. \u003Cbr\u003EЛечение \u003Cbr\u003EПрименяют соответствующее симптоматическое лечение для облегчения раздражения, вызванного нанесением чрезмерного количества препарата. Лечение при случайном попадании препарата внутрь следует проводить, исходя из клинической ситуации, либо в соответствии с рекомендациями местного Национального токсикологического центра при наличии таковых."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность \u003Cbr\u003EКонтролируемых исследований с участием беременных женщин, которые используют гель для наружного применения, содержащий комбинацию клиндамицина и бензоила пероксида, проведено не было. \u003Cbr\u003EДанные по использованию препаратов для наружного применения, содержащих одно из действующих веществ (клиндамицин или бензоила пероксид), у беременных женщин ограничены. Доклинические исследования не подтверждают прямого либо косвенного нежелательного воздействия, которое может быть отнесено к репродуктивной токсичности. \u003Cbr\u003EУчитывая низкий уровень системного воздействия клиндамицина и бензоила пероксида, нежелательное воздействие на развитие беременности является маловероятным. \u003Cbr\u003EТем не менее, комбинацию клиндамицина и бензоила пероксида следует назначать во время беременности только в случае, если ожидаемая польза для матери превышает потенциальный риск для плода. \u003Cbr\u003EГрудное вскармливание \u003Cbr\u003EНет данных о безопасности местного применения комбинации клиндамицина и бензоила пероксида в период кормления грудью. \u003Cbr\u003EКлиндамицин и бензоила пероксид обладают слабой чрескожной абсорбцией, однако данные об экскреции клиндамицина или бензоила пероксида при наружном применении в грудное молоко отсутствуют. Клиндамицин экскретируется в грудное молоко при пероральном и парентеральном применении. \u003Cbr\u003EКомбинацию клиндамицина и бензоила пероксида следует использовать в период лактации только в том случае, если ожидаемая польза для матери превышает потенциальный риск для ребенка. \u003Cbr\u003EВо избежание случайного попадания препарата в организм ребенка при его применении в период лактации препарат не следует наносить на кожу груди."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Негативное влияние препарата на способность управлять транспортными средствами или механизмами является маловероятным."},{"name":"Особые указания","value":"Следует избегать попадания препарата в рот, глаза, на поверхность губ, другие слизистые оболочки, а также на раздраженные поврежденные области кожи. При случайном попадании геля на указанные участки их следует хорошо промыть водой. \u003Cbr\u003EВо время первой недели лечения у большинства пациентов усиливается шелушение и покраснение кожи. В зависимости от тяжести данных побочных эффектов пациенты могут использовать увлажняющие средства, временно снизить частоту применения препарата либо временно прекратить применение. Эффективность препарата при применении с частотой реже одного раза в день не изучалась. \u003Cbr\u003EПри возникновении сильного раздражения кожи (например, сильная эритема, сильная сухость кожи и зуд, сильное покалывание/жжение) применение препарата следует прекратить. \u003Cbr\u003EПоскольку бензоила пероксид может вызывать повышенную чувствительность к солнечному свету, следует избегать длительного воздействия солнечных лучей, а также не посещать солярий в период применения препарата. В случае, если пребывания на солнце нельзя избежать, следует использовать солнцезащитные косметические средства для кожи и одежду, защищающую от солнечных лучей. \u003Cbr\u003EПри наличии у пациента солнечных ожогов следует прекратить применение препарата до излечения ожогов. \u003Cbr\u003EПрепарат способен обесцветить волосы и цветную ткань. Следует избегать попадания препарата на волосы, ткань, мебель или ковровое покрытие. \u003Cbr\u003EПсевдомембранозный колит \u003Cbr\u003EСлучаи псевдомембранозного колита были отмечены при использовании практически всех антибактериальных средств, включая клиндамицин. Степень их выраженности варьирует по тяжести от слабой до опасной для жизни. Псевдомембранозный колит может возникнуть через несколько недель после прекращения терапии. \u003Cbr\u003EНесмотря на то, что возникновение псевдомембранозного колита маловероятно при наружном применении комбинации клиндамицина и бензоила пероксида, в случае возникновения длительной или серьезной диареи либо если пациент страдает коликами в животе, лечение следует немедленно прекратить и обратиться к врачу, поскольку симптомы могут означать присутствие колита, вызванного приемом антибиотика. \u003Cbr\u003EРезистентность к клиндамицину \u003Cbr\u003EБензоила пероксид снижает вероятность появления микроорганизмов, резистентных к клиндамицину. Тем не менее, у пациентов, недавно использовавших клиндамицин или эритромицин для парентерального или наружного применения, более вероятно наличие пропионибактерий и сапрофитной флоры с ранее приобретенной антимикробной резистентностью. \u003Cbr\u003EПерекрёстная резистентность \u003Cbr\u003EБыло установлено наличие перекрёстной резистентности между клиндамицином и линкомицином. Резистентность к клиндамицину часто связана с резистентностью к эритромицину. \u003Cbr\u003EС осторожностью:Одновременное применение с другими местными средствами лечения акне следует проводить с осторожностью по причине возможного возникновения кумулятивного раздражения кожи, которое иногда может быть тяжелым, в особенности при применении средств с отшелушивающим либо абразивным действием. \u003Cbr\u003EПрепарат Клиндовит Комбо следует применять с осторожностью при необходимости одновременного приема с миорелаксантами периферического действия. \u003Cbr\u003EПрепарат Клиндовит Комбо следует применять с осторожностью у пациентов с атопией в связи с возможным усилением сухости кожи."},{"name":"Взаимодействие","value":"Так как клиндамицин проявляет антагонизм с эритромицином, препарат Клиндовит Комбо не следует использовать в комбинации с препаратами, содержащими эритромицин. Установлено, что клиндамицин нарушает нейромышечную передачу и, следовательно, может усиливать действие миорелаксантов периферического действия. \u003Cbr\u003EСледует избегать совместного применения комбинации клиндамицина и бензоила пероксида с третиноином, изотретиноином и тазаротеном, поскольку бензоила пероксид способен снижать их эффективность и усиливать раздражение кожи. При необходимости комбинированного лечения препараты следует применять в разное время дня (например, один препарат утром и другой препарат вечером). \u003Cbr\u003EИспользование препаратов для местного применения, содержащих бензоила пероксид, одновременно с препаратами для местного применения, содержащими сульфонамид, может вызывать временное изменение цвета кожи и волос в месте нанесения препарата (окраска в желтый или оранжевый цвет)."},{"name":"Регистрационный номер","value":"ЛП-№(000122)-(РГ-RU)"},{"name":"Дата государственной регистрации","value":"19.07.2022"},{"name":"Владелец регистрационного удостоверения","value":"АКРИХИН"},{"name":"Изготовитель","value":"Фармаприм"},{"name":"Фасовщик","value":"Фармаприм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Республика Молдова"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_16410466296638668084"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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639 ₽

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  • Азелик гель д/нар. прим., 15%, 30 мл, 30 г
    –1 %
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    Азелик гель д/нар. прим., 15%, 30 мл, 30 г

    Рейтинг товара: 4.8 из 5
    на основе 83 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 992 ₽ вместо 1 002
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  • Зеркалин Интенсив гель д/нар. прим., 50 мг+10 мг/г, 30 мл, 25 г
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mhf32exm8lj/toggleWishlist":{"skuId":"101818962483","productId":1770132902,"offerId":"aW-X9d7Bt94j6tiuR4LJjQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQq7H3vsnoyp9EEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIpquIzAYQs6SIp/sCGPbg0Acg5dnBBw==","sign":"mPMYaAuW+UncpgLWQlW7xv/AemIU6yH81gBUGTE2UVI="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-mhf32exm8lj/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Зеркалин Интенсив гель д/нар. прим., 50 мг+10 мг/г, 30 мл, 25 г

    Рейтинг товара: 4.9 из 5
    на основе 25 оценок
    Цена 963 ₽
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  • Скиноклир гель д/нар. прим. туба, 15%, 30 мл, 30 г
    ВАМ–16 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-uuxdomh2rmo/toggleWishlist":{"skuId":"228004394","productId":1780858049,"offerId":"mZXd3d_Rzj7L6xy6HWK4pw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQq7H3vsnoyp9EEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIwfmW0QYQqqTcbBiEqbIIIOXZwQc=","sign":"6Mx4SUF2IaIq/FnSCsT7U0mPvvLsNgJLOuktmlTcYWk="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-uuxdomh2rmo/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Скиноклир гель д/нар. прим. туба, 15%, 30 мл, 30 г

    Рейтинг товара: 4.8 из 5
    на основе 72 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 648 ₽ вместо 655
    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  • Базирон АС гель д/нар. прим., 2,5 %, 40 мл, 40 г
    –1 %
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    Базирон АС гель д/нар. прим., 2,5 %, 40 мл, 40 г

    Рейтинг товара: 4.9 из 5
    на основе 71 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 312 ₽ вместо 1 325
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  • Скиноклир крем д/нар.прим. туба, 20%, 30 г
    ВАМ–16 %
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    Скиноклир крем д/нар.прим. туба, 20%, 30 г

    Рейтинг товара: 4.8 из 5
    на основе 53 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 675 ₽ вместо 682
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  • Клензит-C гель д/нар. прим., 30 г
    –2 %
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    Клензит-C гель д/нар. прим., 30 г

    Рейтинг товара: 4.9 из 5
    на основе 58 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 403 ₽ вместо 1 431
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  • Зеркалин р-р д/нар. прим. фл., 10 мг/мл, 30 мл
    –21 %
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    Зеркалин р-р д/нар. прим. фл., 10 мг/мл, 30 мл

    Рейтинг товара: 4.9 из 5
    на основе 16 оценок
    Цена 579 ₽ вместо 733
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  • Постакнетин гель, 10 мл, 10 г
    –1 %
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    Постакнетин гель, 10 мл, 10 г

    Рейтинг товара: 4.5 из 5
    на основе 21 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 620 ₽ вместо 626
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  • Розамет крем, 1%, 25 мл, 25 г
    ВАМ–7 %
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    Розамет крем, 1%, 25 мл, 25 г

    Рейтинг товара: 4.5 из 5
    на основе 10 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 340 ₽ вместо 343
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  • Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.
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    Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 41 оценка
    Цена 2 078 ₽
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  • Клензит гель д/нар. прим., 15 г
    –1 %
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    Клензит гель д/нар. прим., 15 г

    Рейтинг товара: 5 из 5
    на основе 9 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 751 ₽ вместо 759
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Инструкция

Показания к применению

Акне (acne vulgaris) легкой и умеренной степени тяжести, особенно с преобладанием воспалительных поражений кожи.

Противопоказания

- Повышенная чувствительность к клиндамицину, линкомицину, бензоила пероксиду и/или к любому из компонентов препарата;
- детский возраст до 12 лет;
- период грудного вскармливания;
- болезнь Крона, язвенный колит, псевдомембранозный колит, в том числе в анамнезе.

Способ применения и дозы

Препарат Клиндовит Комбо предназначен только для наружного применения.
Препарат следует наносить тонким слоем на всю поражённую область 1 раз в день после тщательного очищения кожи очищающим средством мягкого действия и полного высыхания кожи.
Гель плохо впитывается в случае нанесения на кожу чрезмерного количества препарата.
После нанесения геля следует вымыть руки.
При необходимости после впитывания геля можно использовать увлажняющее средство.
При возникновении сухости кожи или шелушения следует сократить частоту применения геля либо временно приостановить лечение.
Эффективность препарата при частоте применения реже 1 раза в день не была изучена.
Более частое, чем рекомендуется инструкцией, нанесение геля не повышает эффективность лечения, но может повысить риск возникновения раздражения кожи.
Длительность курса лечения, необходимая для достижения терапевтического эффекта, составляет от 2 до 5 недель, но не более 12 недель.
Безопасность и эффективность применения комбинации клиндамицина и бензоила пероксида при лечении акне длительностью более 12 недель не были изучены. Следует тщательно оценить ожидаемую пользу для пациента при назначении лечения длительностью более 12 недель непрерывного использования.
Особые группы пациентов
Дети
Безопасность и эффективность применения комбинации клиндамицина и бензоила пероксида не были изучены для детей младше 12 лет, поэтому в данной популяции использование комбинации клиндамицина и бензоила пероксида не рекомендуется.
Пациенты пожилого возраста
Специальные рекомендации для пожилых пациентов отсутствуют.
Пациенты с почечной недостаточностью
Необходимость в коррекции дозы отсутствует.
Поскольку абсорбция клиндамицина и бензоила пероксида через кожу при наружном применении является слабой, маловероятно влияние почечной недостаточности на возникновение клинически значимого системного воздействия.
Пациенты с печеночной недостаточностью
Необходимость в коррекции дозы отсутствует.
Поскольку абсорбция клиндамицина и бензоила пероксида через кожу при наружном применении является слабой, маловероятно влияние печеночной недостаточности на возникновение клинически значимого системного воздействия.
Полная инструкция
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Клиндовит Комбо гель д/нар.прим
Клиндовит Комбо гель д/нар.прим, 50 мг+10 мг/г, 15 г
4.8
(4)
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1 вопрос
Инструкция

639 ₽

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4.8
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    Цена 648 ₽ вместо 771
  • Базирон АС гель д/нар. прим., 2,5 %, 40 мл, 40 г
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    Базирон АС гель д/нар. прим., 2,5 %, 40 мл, 40 г

    Цена 1 312 ₽ вместо 1 325
  • Скиноклир крем д/нар.прим. туба, 20%, 30 г
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    Скиноклир крем д/нар.прим. туба, 20%, 30 г

    Цена 675 ₽ вместо 804
  • Клензит-C гель д/нар. прим., 30 г
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    Клензит-C гель д/нар. прим., 30 г

    Цена 1 403 ₽ вместо 1 431
  • Зеркалин р-р д/нар. прим. фл., 10 мг/мл, 30 мл
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    Зеркалин р-р д/нар. прим. фл., 10 мг/мл, 30 мл

    Цена 579 ₽ вместо 733
  • Реклама
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  • Постакнетин гель, 10 мл, 10 г
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    Постакнетин гель, 10 мл, 10 г

    Цена 620 ₽ вместо 626
  • Розамет крем, 1%, 25 мл, 25 г
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    Розамет крем, 1%, 25 мл, 25 г

    Цена 340 ₽ вместо 364
  • Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.
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    Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.

    Цена 2 078 ₽
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