Конвулекс капли д/вн. приема

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вспомогательные вещества: натрия сахаринат 8,5 мг, ароматизатор с апельсиновым вкусом 2,0 мг, хлористоводородная кислота (37%) достаточное количество для доведения pH до 9,0, натрия гидроксид достаточное количество для доведения pH до 9,0, вода очищенная до 1,0 мл."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Вальпроевая кислота"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"КОНВУЛЕКС принимают внутрь, 2-3 раза в день, не зависимо от приема пищи, с небольшим количеством жидкости.\u003Cbr\u003EВзрослые - при всех рекомендуемых показаниях. Начальная суточная доза составляет 600 мг, с постепенным увеличением дозы на 150-250 мг каждые три дня до достижения клинического эффекта (исчезновения припадков).\u003Cbr\u003EНачальная доза при монотерапии - 5-15 мг/кг/сут, затем эту дозу постепенно повышают на 5-10 мг/кг/нед. Рекомендованная суточная доза - около 1000-2000 мг в сутки, т.е. 20-25 мг/кг, при необходимости доза может быть увеличена до максимальной дозы 2500 мг в сутки (30 мг/кг массы тела).\u003Cbr\u003EМаксимальная доза 30 мг/кг/сут (у пациентов с ускоренным метаболизмом вальпроевой кислоты, выявленным при контроле за концентрацией вальпроевой кислоты в плазме крови, максимальная доза может быть увеличена до 60 мг/кг/сут).\u003Cbr\u003EПри комбинированной терапии - 10-30 мг/кг/сут с последующим повышением дозы на 5-10 мг/кг/нед.\u003Cbr\u003EДети с массой тела более 25 кг - при всех рекомендуемых показаниях. Начальная суточная доза составляет 300 мг (5-15 мг/кг/cyr), с постепенным увеличением дозы (на 5-10 мг/кг/нед) до достижения клинического эффекта (исчезновения судорожных припадков), что обычно составляет 1000-1500 мг в сутки (20-30 мг/кг/сут). Максимальная доза 30 мг/кг/сут (у пациентов с ускоренным метаболизмом вальпроевой кислоты, выявленным при контроле за концентрацией вальпроевой кислоты в плазме крови, максимальная доза может быть увеличена до 60 мг/кг/сут).\u003Cbr\u003EДети с массой тела 7,5-25 кг - при всех рекомендуемых показаниях. Средняя суточная доза при монотерапии - 15-45 мг/кг, максимальная - 50 мг/кг. При комбинированной терапии - 30-100 мг/кг/сут."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Со стороны ЦНС: возможно дрожание кистей или рук; редко - изменения поведения, настроения или психического состояния, диплопия, нистагм, пятна перед глазами, нарушения координации движений, головокружение, сонливость, головная боль, необычное возбуждение, двигательное беспокойство или раздражительность.\u003Cbr\u003EСо стороны пищеварительной системы: возможны слабые спазмы в животе или в области желудка, потеря аппетита, диарея, нарушения пищеварения, тошнота, рвота; редко - запоры, панкреатит.\u003Cbr\u003EСо стороны системы свертывания крови: тромбоцитопения, удлинение времени кровотечения.\u003Cbr\u003EСо стороны обмена веществ: необычное уменьшение или увеличение массы тела.\u003Cbr\u003EСо стороны гинекологического статуса: нарушения менструального цикла.\u003Cbr\u003EДерматологические реакции: алопеция.\u003Cbr\u003EАллергические реакции: кожная сыпь."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Противоэпилептическое средство. Полагают, что механизм действия связан с повышением содержания GABA в ЦНС, что обусловлено ингибированием GABA-трансаминазы, а также уменьшением обратного захвата GABA в тканях головного мозга. Это, по-видимому, приводит к уменьшению возбудимости и судорожной готовности моторных зон головного мозга. Способствует улучшению психического состояния и настроения больных."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"противоэпилептические средства"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"капли для приема внутрь"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":16382542,"name":"Подробная комплектация"}],"isMainProperty":false,"name":"Комплектация","value":"Дозирующее устройство."}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Капли для приема внутрь следует хранить в защищенном от света месте при температуре не выше 25°С."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Симптомы: тошнота, рвота, головокружение, диарея, нарушение функции дыхания, мышечная гипотония, гипорефлексия, миоз, кома.\u003Cbr\u003EЛечение: промывание желудка (не позже 10-12 ч), прием активированного угля, гемодиализ, форсированный диурез, поддержание жизненно важных функций."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Во время лечения следует предохраняться от беременности. В экспериментах на животных выявлено тератогенное действие вальпроевой кислоты. Частота развития дефектов нервной трубки у детей, рожденных женщинами, принимавшими вальпроаты в первом триместре беременности, составляет 1-2%. Целесообразно в связи с этим применение препаратов фолиевой кислоты. В первом триместре беременности не следует начинать лечения КОНВУЛЕКСОМ®. Если беременная уже получает препарат, то в связи с риском учащения припадков лечение прерывать не следует. Препарат следует применять в наименьших эффективных дозах, избегая сочетания с другими противосудорожными средствами и, по возможности, регулярно контролируя концентрацию вальпроевой кислоты в плазме."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения следует соблюдать осторожность при вождении транспортных средств и других видах деятельности, требующих высокой концентрации внимания и быстрых психомоторных реакций."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"С осторожностью применяют у пациентов с патологическими изменениями крови, при органических заболеваниях мозга, заболеваниях печени в анамнезе, гипопротеинемии, нарушениях функции почек.\u003Cbr\u003EПациентам, которые получают другие противосудорожные средства, лечение вальпроевой кислотой следует начинать постепенно, достигая клинически эффективной дозы через 2 недели. Затем проводят постепенную отмену других противосудорожных средств. У пациентов, не получавших лечения другими противосудорожными средствами, клинически эффективная доза должна быть достигнута через 1 неделю.\u003Cbr\u003EСледует иметь в виду, что риск развития побочных эффектов со стороны печени повышен при проведении комбинированной противосудорожной терапии.\u003Cbr\u003EВ период лечения необходимо регулярно контролировать функцию печени, картину периферической крови, состояние свертывающей системы крови (особенно в течение первых 6 месяцев лечения).\u003Cbr\u003EУ детей повышен риск развития тяжелого или угрожающего жизни гепатотоксического действия. У пациентов в возрасте до 2 лет и у детей, получающих комбинированную терапию, риск еще более высок, но с увеличением возраста он снижается."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"При одновременном применении нейролептиков, антидепрессантов, ингибиторов МАО, производных бензодиазепина, этанола усиливается угнетающее влияние на ЦНС.\u003Cbr\u003EПри одновременном применении средств, обладающих гепатотоксическим действием, возможно усиление гепатотоксического действия.\u003Cbr\u003EПри одновременном применении усиливаются эффекты антиагрегантов (в т.ч. ацетилсалициловой кислоты) и антикоагулянтов.\u003Cbr\u003EПри одновременном применении повышается концентрация зидовудина в плазме крови, что приводит к усилению его токсичности.\u003Cbr\u003EПри одновременном применении с карбамазепином уменьшается концентрация вальпроевой кислоты в плазме крови вследствие повышения скорости ее метаболизма, обусловленного индукцией микросомальных ферментов печени под влиянием карбамазепина. Вальпроевая кислота потенцирует токсическое действие карбамазепина.\u003Cbr\u003EПри одновременном применении замедляется метаболизм ламотриджина и увеличивается его T1/2.\u003Cbr\u003EПри одновременном применении с мефлохином повышается метаболизм вальпроевой кислоты в плазме крови и повышается риск развития судорог.\u003Cbr\u003EПри одновременном применении с меропенемом возможно снижение концентрации вальпроевой кислоты в плазме крови; с примидоном - повышение концентрации примидона в плазме крови; с салицилатами - возможно усиление эффектов вальпроевой кислоты вследствие ее вытеснения салицилатами из связи с белками плазмы крови.\u003Cbr\u003EПри одновременном применении с фелбаматом повышается концентрация вальпроевой кислоты в плазме крови, что сопровождается проявлениями токсического действия (тошнота, сонливость, головная боль, уменьшение количества тромбоцитов, когнитивные нарушения).\u003Cbr\u003EПри одновременном применении с фенитоином в течение нескольких первых недель общая концентрация фенитоина в плазме крови может уменьшаться за счет его вытеснения из мест связывания с белками плазмы вальпроатом натрия, индукции микросомальных ферментов печени и ускорения метаболизма фенитоина. Далее происходит ингибирование метаболизма фенитоина вальпроатом и, вследствие этого, повышение концентрации фенитоина в плазме крови. Фенитоин уменьшает концентрацию вальпроата в плазме крови, вероятно, за счет повышения его метаболизма в печени. Полагают, что фенитоин как индуктор печеночных ферментов, возможно, также повышает образование второстепенного, но обладающего гепатотоксичностью, метаболита вальпроевой кислоты.\u003Cbr\u003EПри одновременном применении вальпроевая кислота вытесняет фенобарбитал из связи с белками плазмы, в результате увеличивается его концентрация в плазме крови. Фенобарбитал повышает скорость метаболизма вальпроевой кислоты, что приводит к уменьшению ее концентрации в плазме крови.\u003Cbr\u003EИмеются сообщения об усилении эффектов флувоксамина и флуоксетина при их одновременном применении с вальпроевой кислотой. 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Конвулекс капли д/вн. приема

3 вопроса

Инструкция

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Товар на Маркете

4.8

24 оценки5 отзывов

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по оценке

по полезности

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Ксения Игнатьева

Добавьте в продажу,конвулекс. Вы понимаете что люди с помощью этого перепората не могут жить! Бога по бойтесь! Что за фигня. Куда делся то!

2 года назад, Москва

Гульназ Гайфуллина

Без этого препарата сын жить не может. Пьёт с детства

Месяц назад

Ольга Ф.

Куплен на Маркете

Товар продавца POLZAru

Опыт использования:: более года

Достоинства:: помогает

3 месяца назад, Екатеринбург

Инкогнито 4816

Куплен на Маркете

Товар продавца POLZAru

Достоинства:: рекомендую.

9 месяцев назад, Ростов-на-Дону

Имя скрыто

Помогает с приступами 5/5 очень хорошая

Отзыв предоставлен партнёром Rate&Goods

5 лет назад

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