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Ксеникал капс., 120 мг, 21 шт.

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4.8
(28)
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Количество штук в упаковке, шт.: 21

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Коротко о товаре

Артикул Маркета
3123148682
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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вспомогательные вещества: тальк - 0.24 мг;"},{"name":"Действующее вещество","value":"Орлистат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28710734"]}}},{"name":"Способ применения и дозы","value":"Длительная терапия пациентов с ожирением или пациентов с избыточной массой тела, имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой:\u003Cbr /\u003Eу взрослых и детей старше 12 лет рекомендованная доза орлистата составляет одну капсулу 120 мг с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).\u003Cbr /\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением:\u003Cbr /\u003Eу взрослых рекомендованная доза орлистата составляет одну капсулу 120 мг с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).\u003Cbr /\u003EЕсли прием пищи пропускают или если пища не содержит жира, то прием препарата Ксеникал также можно пропустить.\u003Cbr /\u003EПрепарат следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема.\u003Cbr /\u003EУвеличение дозы орлистата свыше рекомендованной (120 мг 3 раза в сутки) не приводит к усилению его терапевтического эффекта.\u003Cbr /\u003EЭффективность и безопасность препарата Ксеникал у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого и детского возраста (младше 12 лет) не исследовались."},{"name":"Побочные действия","value":"Данные клинических исследований\u003Cbr\u003EДля описания частоты побочных реакций используются следующие категории: очень часто (\u003E1/10), часто (\u003E1/100, \u003C1/10), нечасто (\u003E1/1000, \u003C1/100), редко (\u003E1/10000, \u003C1/1000) и очень редко (\u003C1/10000), включая отдельные случаи.\u003Cbr\u003EПобочные реакции на орлистат возникали главным образом со стороны желудочно- кишечного тракта и были обусловлены фармакологическим действием препарата, препятствующего всасыванию жиров пищи. Очень часто отмечались такие явления, как маслянистые выделения из прямой кишки, выделение газов с некоторым количеством отделяемого, императивные позывы на дефекацию, стеаторея, учащение дефекации, жидкий стул, метеоризм, боли или дискомфорт в животе.\u003Cbr\u003EИх частота увеличивается при повышении содержания жира в питании. Больных следует информировать о возможности возникновения побочных реакций со стороны желудочно- кишечного тракта и обучить, как устранять их путем лучшего соблюдения диеты, особенно в отношении количества содержащегося в ней жира. Применение диеты с низким содержанием жира уменьшает вероятность побочных действий со стороны желудочно-кишечного тракта и тем самым помогает пациентам контролировать и регулировать потребление жиров.\u003Cbr\u003EКак правило, указанные побочные реакции являются слабо выраженными и транзиторными. Они возникали на ранних этапах лечения (в первые 3 месяца), причем у большинства больных было не более одного эпизода таких реакций.\u003Cbr\u003EПри лечении препаратом Ксеникал часто возникают следующие нежелательные явления со стороны желудочно-кишечного тракта: \"мягкий\" стул, боли или дискомфорт в прямой кишке, недержание кала, вздутие живота, поражение зубов, поражение десен.\u003Cbr\u003EОтмечались также очень часто: головные боли, инфекции верхних дыхательных путей, грипп; часто: инфекции нижних дыхательных путей, инфекции мочевыводящих путей, дисменорея, тревога, слабость.\u003Cbr\u003EУ больных с сахарным диабетом 2 типа характер и частота нежелательных явлений были сопоставимы с таковыми у лиц без сахарного диабета с избыточной массой тела и ожирением. Единственными новыми побочными явлениями у пациентов с сахарным диабетом 2 типа были гипогликемические состояния, возникавшие с частотой \u003E2% и инцидентностью \u003E1% по сравнению с плацебо (которые могли возникать в результате улучшения компенсации углеводного обмена), и часто - вздутие живота.\u003Cbr\u003EВ 4-х летнем клиническом исследовании общий профиль безопасности не отличался от такового, полученного в 1- и 2-летних исследованиях. При этом общая частота возникновения нежелательных явлений со стороны желудочно-кишечного тракта ежегодно уменьшалась на протяжении 4-х летнего периода приема препарата.\u003Cbr\u003EПостмаркетинговое наблюдение\u003Cbr\u003EОписаны редкие случаи аллергических реакций, главными клиническими симптомами которых были зуд, сыпь, крапивница, ангионевротический отек, бронхоспазм и анафилаксия.Описаны очень редкие случаи буллезной сыпи, повышения активности трансаминаз и щелочной фосфатазы, а также отдельные, возможно серьезные, случаи развития гепатита (причинно-следственная связь с приемом препарата Ксеникал или патофизиологические механизмы развития не установлены).\u003Cbr\u003EПри одновременном назначении препарата Ксеникал и антикоагулянтов зарегистрированы случаи снижения протромбина, увеличение значений международного нормализованного отношения (МНО) и несбалансированной терапии антикоагулянтами, что приводило к изменению гемостатических параметров.\u003Cbr\u003EЗарегистрированы случаи ректального кровотечения, дивертикулита, панкреатита, холелитиаза и оксалатной нефропатии (частота возникновения не известна).\u003Cbr\u003EПри одновременном приеме орлистата и противоэпилептических препаратов наблюдались случаи развития судорог (см. раздел \"Взаимодействие с другими лекарственными средствами\")."},{"name":"Фармакологическое действие","value":"Ксеникал - мощный, специфический и обратимый ингибитор желудочно-кишечных липаз, обладающий продолжительным действием. Его терапевтическое действие осуществляется в просвете желудка и тонкого кишечника и заключается в образовании ковалентной связи с активным сериновым участком желудочной и панкреатической липаз. Инактивированный фермент при этом теряет способность расщеплять жиры пищи, поступающие в форме триглицеридов, на всасывающиеся свободные жирные кислоты и моноглицериды. Поскольку нерасщепленные триглицериды не всасываются, возникающее вследствие этого уменьшение поступления калорий в организм приводит к уменьшению массы тела. Таким образом, терапевтическое действие препарата осуществляется без всасывания в системный кровоток.\u003Cbr\u003EСудя по результатам содержания жира в кале, действие орлистата начинается через 24-48 часов после приема. После отмены препарата содержание жира в кале через 48-72 часа обычно возвращается к уровню, имевшему место до начала терапии."},{"name":"Фармакологическая группа","value":"ингибиторы липазы ЖКТ"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25°С, в оригинальной упаковке. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"В клинических исследованиях у лиц с нормальной массой тела и больных ожирением прием разовых доз 800 мг или многократный прием препарата по 400 мг 3 раза в сутки в течение 15 дней не сопровождался появлением существенных нежелательных явлений. Кроме того, у больных ожирением есть опыт применения орлистата по 240 мг 3 раза в сутки в течение 6 месяцев, что не сопровождалось достоверным увеличением частоты нежелательных явлений.\u003Cbr\u003EВ случаях передозировки препарата Ксеникал сообщалось либо об отсутствии . нежелательных явлений, либо нежелательные явления не отличались от тех, которые наблюдаются при приеме препарата в терапевтических дозах.\u003Cbr\u003EВ случае выраженной передозировки препарата Ксеникал рекомендуется наблюдать пациента в течение 24 часов. По данным исследований у человека и животных, любые системные эффекты, которые можно было бы связать с липазоингибирующими свойствами орлистата, должны быть быстро обратимы."},{"name":"Применение при беременности и кормлении грудью","value":"В исследованиях репродуктивной токсичности на животных тератогенного и эмбриотоксического эффекта препарата не наблюдалось. В отсутствие тератогенного эффекта у животных ожидать подобного эффекта у человека не следует. Однако из-за отсутствия клинических данных Ксеникал не следует назначать беременным.\u003Cbr /\u003EНеизвестно, проникает ли орлистат в грудное молоко, поэтому его применение в период грудного вскармливания противопоказано.\u003Cbr /\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат Ксеникал не влияет на способность управлять транспортными средствами и механизмами."},{"name":"Особые указания","value":"Ксеникал эффективен в плане длительного контроля массы тела (снижение массы тела и ее поддержание на новом уровне, предотвращение повторной прибавки массы тела).\u003Cbr\u003EЛечение препаратом Ксеникал приводит к улучшению профиля факторов риска и заболеваний, сопутствующих ожирению, включая гиперхолестеринемию, сахарный диабет 2 типа, нарушение толерантности к глюкозе, гиперинсулинемию, артериальную гипертензию, и к уменьшению количества висцерального жира.\u003Cbr\u003EПри использовании в комбинации с такими гипогликемическими препаратами, как метформин, производные сульфонилмочевины и/или инсулин у больных сахарным диабетом 2 типа с избыточной массой тела (индекс массы тела (ИМТ) \u003E 28 кг/м2) или ожирением (ИМТ \u003E30 кг/м2), Ксеникал в сочетании с умеренно гипокалорийной диетой дает дополнительное улучшение компенсации углеводного обмена.\u003Cbr\u003EВ клинических исследованиях у большинства больных концентрации витаминов A, D, Е, К и бета-каротина в ходе четырех лет терапии орлистатом оставались в пределах нормы.\u003Cbr\u003EДля обеспечения адекватного поступления всех питательных веществ можно назначить поливитамины.\u003Cbr\u003EПациент должен получать сбалансированную, умеренно гипокалорийную диету, содержащую не более 30% калоража в виде жиров. Рекомендуется питание, богатое фруктами и овощами. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема.\u003Cbr\u003EВероятность побочных реакций со стороны желудочно-кишечного тракта может увеличиваться, если Ксеникал принимают на фоне питания, богатого жирами (например, 2000 ккал/сутки, из них более 30% в виде жиров, что равняется примерно 67 г жира).\u003Cbr\u003EСуточное потребление жиров должно быть распределено на три основных приема. Если Ксеникал принимают с пищей, очень богатой жиром, вероятность желудочно-кишечных реакций увеличивается.\u003Cbr\u003EУ больных сахарным диабетом 2 типа уменьшение массы тела при лечении препаратом Ксеникал сопровождается улучшением компенсации углеводного обмена, что может позволить или потребовать снижения дозы гипогликемических препаратов (например, производных сульфонилмочевины)."},{"name":"Взаимодействие","value":"Не выявлено взаимодействия с амитриптилином, аторвастатином, бигуанидами, дигоксином, фибратами, флуоксетином, лозартаном, фенитоином, пероральными контрацептивами, фентермином, правастатином, варфарином, нифедипином ГИТС (гастро-интестинальная терапевтическая система) и нифедипином с медленным высвобождением, сибутрамином или алкоголем (на основании исследований. взаимодействий между лекарственными средствами). Однако необходимо следить за показателями МНО при сопутствующей терапии варфарином или другими пероральными антикоагулянтами.\u003Cbr\u003EПри одновременном приеме с препаратом Ксеникал отмечалось уменьшение всасывания витаминов D, Е и бета-каротина. Если рекомендованы поливитамины, их следует принимать не менее чем через 2 часа после приема препарата Ксеникал или перед сном. При одновременном приеме препарата Ксеникал и циклоспорина отмечалось снижение плазменных концентраций циклоспорина, поэтому рекомендуется более частое определение концентраций циклоспорина в плазме при одновременном приеме циклоспорина и препарата Ксеникал.\u003Cbr\u003EПри пероральном назначении амиодарона во время терапии препаратом Ксеникал отмечалось снижение системной экспозиции амиодарона и дезэтиламиодарона (на 25-30%), однако в связи со сложной фармакокинетикой амиодарона, клиническая значимость этого явления не ясна. Добавление препарата Ксеникал к длительной терапии амиодароном возможно приведет к снижению терапевтического эффекта амиодарона (исследований не проводилось).\u003Cbr\u003EСледует избегать одновременного приема препарата Ксеникал и акарбозы, из-за отсутствия данных фармакокинетических исследований.\u003Cbr\u003EПри одновременном приеме орлистата и противоэпилептических препаратов наблюдались случаи развития судорог. Причинно-следственная связь между развитием судорог и терапией орлистатом не установлена. Тем не менее, следует мониторировать состояние пациентов на предмет возможных изменений в частоте и/или тяжести судорожного синдрома."},{"name":"Регистрационный номер","value":"П N014903/01"},{"name":"Дата государственной регистрации","value":"15.08.2019; 21.12.22"},{"name":"Владелец регистрационного удостоверения","value":"Cheplapharm Arzneimittel","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:35810530"]}}},{"name":"Страна-производитель","value":"Италия"},{"name":"Название препарата","value":"Ксеникал","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18008472"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"1909478034280709381":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кишечник, пищеварительная система"},{"name":"Назначение","value":"избыточная масса тела"},{"name":"Показания к применению","value":"Длительная терапия пациентов с ожирением (индекс массы тела (ИМТ) ≥30 кг/м2) или пациентов с избыточной массой тела (ИМТ \u003E28 кг/м2), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой.\u003Cbr /\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением."},{"name":"Противопоказания","value":"Синдром хронической мальабсорбции, холестаз, повышенная чувствительность к препарату или любым другим компонентам, содержащимся в капсуле.\u003Cbr /\u003EДетский возраст до 12 лет.\u003Cbr /\u003EБеременность, период грудного вскармливания."},{"name":"Состав","value":"Одна капсула содержит: активное вещество: орлистат 120 мг (в виде пеллет 240 мг);\u003Cbr\u003E состав пеллет: орлистат - 120 мг, целлюлоза микрокристаллическая - 93.60 мг, карбоксиметилкрахмал натрия (примогель) - 7.20 мг, повидон К-30 - 12.00 мг, натрия лаурилсульфат-7.20 мг; вспомогательные вещества: тальк - 0.24 мг;"},{"name":"Действующее вещество","value":"Орлистат"},{"name":"Способ применения и дозы","value":"Длительная терапия пациентов с ожирением или пациентов с избыточной массой тела, имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой:\u003Cbr /\u003Eу взрослых и детей старше 12 лет рекомендованная доза орлистата составляет одну капсулу 120 мг с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).\u003Cbr /\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением:\u003Cbr /\u003Eу взрослых рекомендованная доза орлистата составляет одну капсулу 120 мг с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).\u003Cbr /\u003EЕсли прием пищи пропускают или если пища не содержит жира, то прием препарата Ксеникал также можно пропустить.\u003Cbr /\u003EПрепарат следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема.\u003Cbr /\u003EУвеличение дозы орлистата свыше рекомендованной (120 мг 3 раза в сутки) не приводит к усилению его терапевтического эффекта.\u003Cbr /\u003EЭффективность и безопасность препарата Ксеникал у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого и детского возраста (младше 12 лет) не исследовались."},{"name":"Побочные действия","value":"Данные клинических исследований\u003Cbr\u003EДля описания частоты побочных реакций используются следующие категории: очень часто (\u003E1/10), часто (\u003E1/100, \u003C1/10), нечасто (\u003E1/1000, \u003C1/100), редко (\u003E1/10000, \u003C1/1000) и очень редко (\u003C1/10000), включая отдельные случаи.\u003Cbr\u003EПобочные реакции на орлистат возникали главным образом со стороны желудочно- кишечного тракта и были обусловлены фармакологическим действием препарата, препятствующего всасыванию жиров пищи. Очень часто отмечались такие явления, как маслянистые выделения из прямой кишки, выделение газов с некоторым количеством отделяемого, императивные позывы на дефекацию, стеаторея, учащение дефекации, жидкий стул, метеоризм, боли или дискомфорт в животе.\u003Cbr\u003EИх частота увеличивается при повышении содержания жира в питании. Больных следует информировать о возможности возникновения побочных реакций со стороны желудочно- кишечного тракта и обучить, как устранять их путем лучшего соблюдения диеты, особенно в отношении количества содержащегося в ней жира. Применение диеты с низким содержанием жира уменьшает вероятность побочных действий со стороны желудочно-кишечного тракта и тем самым помогает пациентам контролировать и регулировать потребление жиров.\u003Cbr\u003EКак правило, указанные побочные реакции являются слабо выраженными и транзиторными. Они возникали на ранних этапах лечения (в первые 3 месяца), причем у большинства больных было не более одного эпизода таких реакций.\u003Cbr\u003EПри лечении препаратом Ксеникал часто возникают следующие нежелательные явления со стороны желудочно-кишечного тракта: \"мягкий\" стул, боли или дискомфорт в прямой кишке, недержание кала, вздутие живота, поражение зубов, поражение десен.\u003Cbr\u003EОтмечались также очень часто: головные боли, инфекции верхних дыхательных путей, грипп; часто: инфекции нижних дыхательных путей, инфекции мочевыводящих путей, дисменорея, тревога, слабость.\u003Cbr\u003EУ больных с сахарным диабетом 2 типа характер и частота нежелательных явлений были сопоставимы с таковыми у лиц без сахарного диабета с избыточной массой тела и ожирением. Единственными новыми побочными явлениями у пациентов с сахарным диабетом 2 типа были гипогликемические состояния, возникавшие с частотой \u003E2% и инцидентностью \u003E1% по сравнению с плацебо (которые могли возникать в результате улучшения компенсации углеводного обмена), и часто - вздутие живота.\u003Cbr\u003EВ 4-х летнем клиническом исследовании общий профиль безопасности не отличался от такового, полученного в 1- и 2-летних исследованиях. При этом общая частота возникновения нежелательных явлений со стороны желудочно-кишечного тракта ежегодно уменьшалась на протяжении 4-х летнего периода приема препарата.\u003Cbr\u003EПостмаркетинговое наблюдение\u003Cbr\u003EОписаны редкие случаи аллергических реакций, главными клиническими симптомами которых были зуд, сыпь, крапивница, ангионевротический отек, бронхоспазм и анафилаксия.Описаны очень редкие случаи буллезной сыпи, повышения активности трансаминаз и щелочной фосфатазы, а также отдельные, возможно серьезные, случаи развития гепатита (причинно-следственная связь с приемом препарата Ксеникал или патофизиологические механизмы развития не установлены).\u003Cbr\u003EПри одновременном назначении препарата Ксеникал и антикоагулянтов зарегистрированы случаи снижения протромбина, увеличение значений международного нормализованного отношения (МНО) и несбалансированной терапии антикоагулянтами, что приводило к изменению гемостатических параметров.\u003Cbr\u003EЗарегистрированы случаи ректального кровотечения, дивертикулита, панкреатита, холелитиаза и оксалатной нефропатии (частота возникновения не известна).\u003Cbr\u003EПри одновременном приеме орлистата и противоэпилептических препаратов наблюдались случаи развития судорог (см. раздел \"Взаимодействие с другими лекарственными средствами\")."},{"name":"Фармакологическое действие","value":"Ксеникал - мощный, специфический и обратимый ингибитор желудочно-кишечных липаз, обладающий продолжительным действием. Его терапевтическое действие осуществляется в просвете желудка и тонкого кишечника и заключается в образовании ковалентной связи с активным сериновым участком желудочной и панкреатической липаз. Инактивированный фермент при этом теряет способность расщеплять жиры пищи, поступающие в форме триглицеридов, на всасывающиеся свободные жирные кислоты и моноглицериды. Поскольку нерасщепленные триглицериды не всасываются, возникающее вследствие этого уменьшение поступления калорий в организм приводит к уменьшению массы тела. Таким образом, терапевтическое действие препарата осуществляется без всасывания в системный кровоток.\u003Cbr\u003EСудя по результатам содержания жира в кале, действие орлистата начинается через 24-48 часов после приема. После отмены препарата содержание жира в кале через 48-72 часа обычно возвращается к уровню, имевшему место до начала терапии."},{"name":"Фармакологическая группа","value":"ингибиторы липазы ЖКТ"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25°С, в оригинальной упаковке. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"В клинических исследованиях у лиц с нормальной массой тела и больных ожирением прием разовых доз 800 мг или многократный прием препарата по 400 мг 3 раза в сутки в течение 15 дней не сопровождался появлением существенных нежелательных явлений. Кроме того, у больных ожирением есть опыт применения орлистата по 240 мг 3 раза в сутки в течение 6 месяцев, что не сопровождалось достоверным увеличением частоты нежелательных явлений.\u003Cbr\u003EВ случаях передозировки препарата Ксеникал сообщалось либо об отсутствии . нежелательных явлений, либо нежелательные явления не отличались от тех, которые наблюдаются при приеме препарата в терапевтических дозах.\u003Cbr\u003EВ случае выраженной передозировки препарата Ксеникал рекомендуется наблюдать пациента в течение 24 часов. По данным исследований у человека и животных, любые системные эффекты, которые можно было бы связать с липазоингибирующими свойствами орлистата, должны быть быстро обратимы."},{"name":"Применение при беременности и кормлении грудью","value":"В исследованиях репродуктивной токсичности на животных тератогенного и эмбриотоксического эффекта препарата не наблюдалось. В отсутствие тератогенного эффекта у животных ожидать подобного эффекта у человека не следует. Однако из-за отсутствия клинических данных Ксеникал не следует назначать беременным.\u003Cbr /\u003EНеизвестно, проникает ли орлистат в грудное молоко, поэтому его применение в период грудного вскармливания противопоказано.\u003Cbr /\u003E"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат Ксеникал не влияет на способность управлять транспортными средствами и механизмами."},{"name":"Особые указания","value":"Ксеникал эффективен в плане длительного контроля массы тела (снижение массы тела и ее поддержание на новом уровне, предотвращение повторной прибавки массы тела).\u003Cbr\u003EЛечение препаратом Ксеникал приводит к улучшению профиля факторов риска и заболеваний, сопутствующих ожирению, включая гиперхолестеринемию, сахарный диабет 2 типа, нарушение толерантности к глюкозе, гиперинсулинемию, артериальную гипертензию, и к уменьшению количества висцерального жира.\u003Cbr\u003EПри использовании в комбинации с такими гипогликемическими препаратами, как метформин, производные сульфонилмочевины и/или инсулин у больных сахарным диабетом 2 типа с избыточной массой тела (индекс массы тела (ИМТ) \u003E 28 кг/м2) или ожирением (ИМТ \u003E30 кг/м2), Ксеникал в сочетании с умеренно гипокалорийной диетой дает дополнительное улучшение компенсации углеводного обмена.\u003Cbr\u003EВ клинических исследованиях у большинства больных концентрации витаминов A, D, Е, К и бета-каротина в ходе четырех лет терапии орлистатом оставались в пределах нормы.\u003Cbr\u003EДля обеспечения адекватного поступления всех питательных веществ можно назначить поливитамины.\u003Cbr\u003EПациент должен получать сбалансированную, умеренно гипокалорийную диету, содержащую не более 30% калоража в виде жиров. Рекомендуется питание, богатое фруктами и овощами. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема.\u003Cbr\u003EВероятность побочных реакций со стороны желудочно-кишечного тракта может увеличиваться, если Ксеникал принимают на фоне питания, богатого жирами (например, 2000 ккал/сутки, из них более 30% в виде жиров, что равняется примерно 67 г жира).\u003Cbr\u003EСуточное потребление жиров должно быть распределено на три основных приема. Если Ксеникал принимают с пищей, очень богатой жиром, вероятность желудочно-кишечных реакций увеличивается.\u003Cbr\u003EУ больных сахарным диабетом 2 типа уменьшение массы тела при лечении препаратом Ксеникал сопровождается улучшением компенсации углеводного обмена, что может позволить или потребовать снижения дозы гипогликемических препаратов (например, производных сульфонилмочевины)."},{"name":"Взаимодействие","value":"Не выявлено взаимодействия с амитриптилином, аторвастатином, бигуанидами, дигоксином, фибратами, флуоксетином, лозартаном, фенитоином, пероральными контрацептивами, фентермином, правастатином, варфарином, нифедипином ГИТС (гастро-интестинальная терапевтическая система) и нифедипином с медленным высвобождением, сибутрамином или алкоголем (на основании исследований. взаимодействий между лекарственными средствами). Однако необходимо следить за показателями МНО при сопутствующей терапии варфарином или другими пероральными антикоагулянтами.\u003Cbr\u003EПри одновременном приеме с препаратом Ксеникал отмечалось уменьшение всасывания витаминов D, Е и бета-каротина. Если рекомендованы поливитамины, их следует принимать не менее чем через 2 часа после приема препарата Ксеникал или перед сном. При одновременном приеме препарата Ксеникал и циклоспорина отмечалось снижение плазменных концентраций циклоспорина, поэтому рекомендуется более частое определение концентраций циклоспорина в плазме при одновременном приеме циклоспорина и препарата Ксеникал.\u003Cbr\u003EПри пероральном назначении амиодарона во время терапии препаратом Ксеникал отмечалось снижение системной экспозиции амиодарона и дезэтиламиодарона (на 25-30%), однако в связи со сложной фармакокинетикой амиодарона, клиническая значимость этого явления не ясна. Добавление препарата Ксеникал к длительной терапии амиодароном возможно приведет к снижению терапевтического эффекта амиодарона (исследований не проводилось).\u003Cbr\u003EСледует избегать одновременного приема препарата Ксеникал и акарбозы, из-за отсутствия данных фармакокинетических исследований.\u003Cbr\u003EПри одновременном приеме орлистата и противоэпилептических препаратов наблюдались случаи развития судорог. Причинно-следственная связь между развитием судорог и терапией орлистатом не установлена. Тем не менее, следует мониторировать состояние пациентов на предмет возможных изменений в частоте и/или тяжести судорожного синдрома."},{"name":"Регистрационный номер","value":"П N014903/01"},{"name":"Дата государственной регистрации","value":"15.08.2019; 21.12.22"},{"name":"Владелец регистрационного удостоверения","value":"Cheplapharm Arzneimittel"},{"name":"Страна-производитель","value":"Италия"},{"name":"Название препарата","value":"Ксеникал"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_13562485229709460710"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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  • Блокатор калорий Три фазы капс., 40 шт., 1 уп.
    –54 %
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    Блокатор калорий Три фазы капс., 40 шт., 1 уп.

    Рейтинг товара: 4 из 5
    на основе 6 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 467 ₽ вместо 508
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  • Жиросжигатель таблетки для похудения, витамин С, пиколинат хрома, экстракт зеленого чая, DEM4R Свелтформ-Р, 500 мг, 60 капсул
    –30 %
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    Жиросжигатель таблетки для похудения, витамин С, пиколинат хрома, экстракт зеленого чая, DEM4R Свелтформ-Р, 500 мг, 60 капсул

    Рейтинг товара: 4.4 из 5
    на основе 33 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 450 ₽ вместо 2 500
    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  • Турбослим усиленная формула набор День+Ночь капс., 0.3 г, 120 шт., 1 уп.
    ВАМ–25 %
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    Турбослим усиленная формула набор День+Ночь капс., 0.3 г, 120 шт., 1 уп.

    Рейтинг товара: 4.4 из 5
    на основе 544 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 797 ₽ вместо 1 815
    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  • Редуксин лайт капс., 30 шт.
    –35 %
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    Редуксин лайт капс., 30 шт.

    Рейтинг товара: 4 из 5
    на основе 6 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 142 ₽ вместо 2 164
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  • Ночь комплекс для похудения капс., 450 мг, 30 шт.
    –54 %
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    Ночь комплекс для похудения капс., 450 мг, 30 шт.

    Рейтинг товара: 4.3 из 5
    на основе 7 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 598 ₽ вместо 651
    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  • Редуксин Лайт Усиленная Формула капс., 0.65 г, 30 шт., 1 уп.
    –1 %
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    Редуксин Лайт Усиленная Формула капс., 0.65 г, 30 шт., 1 уп.

    Рейтинг товара: 3.7 из 5
    на основе 23 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 3 316 ₽ вместо 3 349
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  • Целлюлоза микрокристаллическая МКЦ АНКИР-Б таб., 120 г, 100 шт., нейтральный, 1 уп.
    –1 %
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    Целлюлоза микрокристаллическая МКЦ АНКИР-Б таб., 120 г, 100 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.3 из 5
    на основе 28 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 273 ₽ вместо 276
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  • Турбослим блокатор калорий таб., 40 шт.
    –1 %
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    Турбослим блокатор калорий таб., 40 шт.

    Рейтинг товара: 4.3 из 5
    на основе 4 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 764 ₽ вместо 772
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  • Турбослим экспресс-похудение капс., саше, 21 шт.
    –1 %
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    Турбослим экспресс-похудение капс., саше, 21 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 075 ₽ вместо 1 086
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  • Турбослим контроль аппетита таб., 20 шт.
    –1 %
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    Турбослим контроль аппетита таб., 20 шт.

    Рейтинг товара: 4.1 из 5
    на основе 128 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 506 ₽ вместо 511
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Инструкция

Показания к применению

Длительная терапия пациентов с ожирением (индекс массы тела (ИМТ) ≥30 кг/м2) или пациентов с избыточной массой тела (ИМТ >28 кг/м2), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой.
В комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением.

Противопоказания

Синдром хронической мальабсорбции, холестаз, повышенная чувствительность к препарату или любым другим компонентам, содержащимся в капсуле.
Детский возраст до 12 лет.
Беременность, период грудного вскармливания.

Способ применения и дозы

Длительная терапия пациентов с ожирением или пациентов с избыточной массой тела, имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой:
у взрослых и детей старше 12 лет рекомендованная доза орлистата составляет одну капсулу 120 мг с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).
В комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением:
у взрослых рекомендованная доза орлистата составляет одну капсулу 120 мг с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).
Если прием пищи пропускают или если пища не содержит жира, то прием препарата Ксеникал также можно пропустить.
Препарат следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема.
Увеличение дозы орлистата свыше рекомендованной (120 мг 3 раза в сутки) не приводит к усилению его терапевтического эффекта.
Эффективность и безопасность препарата Ксеникал у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого и детского возраста (младше 12 лет) не исследовались.
Полная инструкция
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Ксеникал капс.
Ксеникал капс., 120 мг, 21 шт.
4.8
(28)
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6 вопросов
Инструкция

1 012 ₽

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4.8
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У продавца:28 оценок·5 отзывов
У всех продавцов:95 оценок·26 отзывов
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user avatar
4 месяца назад • Natalia Frantsuzova • Куплен на Маркете
Достоинства: соответствует информации инструкции. снижает вес при правильном применении. Лучший на рынке лекарств
Недостатки: ценовая политика. цена могла бы быть и пониже
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3 недели назад • 263277 каоашник • Куплен на Маркете
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Месяц назад • Светлана Балацкая • Куплен на Маркете
Достоинства: единственный препарат который работает 👌
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    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 167 ₽ вместо 200
  • Таблетница Пилюля "Аптечка" ( 6 отделений)
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    Таблетница Пилюля "Аптечка" ( 6 отделений)

    Цена 145 ₽ вместо 201
  • Таблетница органайзер на неделю, контейнер для таблеток, бокс, на 7 дней, 4 приема, 28 ячеек
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    Таблетница органайзер на неделю, контейнер для таблеток, бокс, на 7 дней, 4 приема, 28 ячеек

    Цена 361 ₽ вместо 690
  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
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    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Цена 812 ₽ вместо 1 039
  • Блокатор калорий Три фазы капс., 40 шт., 1 уп.
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    Блокатор калорий Три фазы капс., 40 шт., 1 уп.

    Цена 467 ₽ вместо 1 016
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    Реклама
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  • Редуксин Лайт Усиленная Формула капс., 0.65 г, 30 шт., 1 уп.
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    Редуксин Лайт Усиленная Формула капс., 0.65 г, 30 шт., 1 уп.

    Цена 3 316 ₽ вместо 3 349
  • Целлюлоза микрокристаллическая МКЦ АНКИР-Б таб., 120 г, 100 шт., нейтральный, 1 уп.
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    Целлюлоза микрокристаллическая МКЦ АНКИР-Б таб., 120 г, 100 шт., нейтральный, 1 уп.

    Цена 273 ₽ вместо 276
  • Турбослим блокатор калорий таб., 40 шт.
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    Турбослим блокатор калорий таб., 40 шт.

    Цена 764 ₽ вместо 772
  • Ночь комплекс для похудения капс., 450 мг, 30 шт.
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    Ночь комплекс для похудения капс., 450 мг, 30 шт.

    Цена 598 ₽ вместо 1 302
  • Таблетница на семь дней для упорядоченного и компактного хранения лекарственных средств и витаминов
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    Таблетница на семь дней для упорядоченного и компактного хранения лекарственных средств и витаминов

    Цена 373 ₽ вместо 490
  • Турбослим усиленная формула набор День+Ночь капс., 0.3 г, 120 шт., 1 уп.
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    Турбослим усиленная формула набор День+Ночь капс., 0.3 г, 120 шт., 1 уп.

    Цена 1 797 ₽ вместо 2 393
  • Турбослим экспресс-похудение капс., саше, 21 шт.
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    Турбослим экспресс-похудение капс., саше, 21 шт.

    Цена 1 075 ₽ вместо 1 086
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 400 ₽ вместо 637
  • VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер
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    VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер

    Цена 245 ₽ вместо 1 400
  • Турбослим контроль аппетита таб., 20 шт.
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    Турбослим контроль аппетита таб., 20 шт.

    Цена 506 ₽ вместо 511
  • Таблетница карманная, дорожная- органайзер-шкатулка на 4 секции для таблеток, витаминов, мелочей, украшений - "Синий сапфир"
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    Таблетница карманная, дорожная- органайзер-шкатулка на 4 секции для таблеток, витаминов, мелочей, украшений - "Синий сапфир"

    Цена 782 ₽ вместо 1 140
  • Таблетница на неделю FUS-250
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    Таблетница на неделю FUS-250

    Цена 1 392 ₽ вместо 2 260
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    Реклама
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  • Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

    Цена 209 ₽ вместо 599
  • Таблетница на неделю, органайзер для лекарств, зеленый, WellMe
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    Таблетница на неделю, органайзер для лекарств, зеленый, WellMe

    Цена 473 ₽ вместо 750
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