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ЯндексЯндекс
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Описание
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Курантил N25 таблетки покрыт. плен. об. 25 мг 120 шт

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Артикул Маркета
103544037275
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Рецептурный препарат
Тип препарата
Назначение
Действующее вещество
Инструкция
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом
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959 ₽
 
1 122 ₽
 
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Курантил N25 таб. п/о плен.
Курантил N25 таблетки покрыт. плен. об. 25 мг 120 шт
Задать вопрос
959 ₽
Скидка: 15%
–15 %
Вместо:1 122 ₽
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Войдите, и станет дешевлеВ аккаунте больше скидок
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Доставка магазина
5 – 6 августа, самовывоз из аптеки  0 ₽
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ЕАПТЕКА
ЕАПТЕКА
Магазин•4.8 141.9K оценок
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Инструкция
Артикул Маркета
103544037275
Бренд
Берлин-Фарма/Берлин-Хеми АГ
Количество штук в упаковке
120 шт.
Тип препарата
лекарственный препарат
Рецептурный препарат
да
Органы и системы
кровеносная система, кровеносные сосуды, сердце
Назначение
лечение и профилактика нарушений мозгового кровообращения, постинсультные состояния, профилактика венозной тромбоэмболии, профилактика инсульта, профилактика тромбоза глубоких вен и тромбоэмболии легочной артерии и ее ветвей, профилактика тромбоэмболии
Показания к применению
– Вторичная профилактика ишемического инсульта и транзиторной ишемической атаки (в сочетании с ацетилсалициловой кислотой в низких дозах или в виде монотерапии при непереносимости ацетилсалициловой кислоты). – В качестве дополнения к пероральным антикоагулянтам непрямого действия для профилактики послеоперационных тромбоэмболических осложнений после замены сердечного клапана.
Противопоказания
– повышенная чувствительность к компонентам препарата; – наследственная непереносимость галактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция; – острый инфаркт миокарда; – нестабильная стенокардия; – распространенный стенозирующий атеросклероз коронарных артерий; – субаортальный стеноз; – декомпенсированная сердечная недостаточность; – выраженная артериальная гипотензия; – коллапс; – тяжелая артериальная гипертензия; – тяжелые нарушения сердечного ритма; – геморрагические диатезы; – заболевания со склонностью к кровотечениям (язвенная болезнь желудка и двенадцатиперстной кишки и др.); – детский возраст до 18 лет (эффективность и безопасность не установлены).
Состав
Ядро: Действующее вещество: дипиридамол – 25,00 мг. Вспомогательные вещества: крахмал кукурузный, лактозы моногидрат, карбоксиметилкрахмал натрия (тип А), желатин, кремния диоксид коллоидный безводный, магния стеарат. Пленочная оболочка: гипромеллоза, тальк, макрогол 6000, титана диоксид, Е 171, краситель хинолиновый желтый, Е 104, симетикона эмульсия.
Действующее вещество
Дипиридамол
Способ применения и дозы
Внутрь, натощак, запивая небольшим количеством воды, не разламывая и не разжевывая. Доза препарата подбирается в зависимости от показаний, тяжести заболевания и реакции пациента на лечение. Длительность курса лечения определяется врачом. Вторичная профилактика ишемического инсульта и транзиторной ишемической атаки (в сочетании с ацетилсалициловой кислотой в низких дозах или в виде монотерапии при непереносимости ацетилсалициловой кислоты) Рекомендуемая доза дипиридамола составляет 300-600 мг в сутки, разделенная на 3 или 4 приема. В качестве дополнения к пероральным антикоагулянтам непрямого действия для профилактики послеоперационных тромбоэмболических осложнений после замены сердечного клапана. Рекомендуемая доза дипиридамола составляет 300-600 мг в сутки, разделенная на 3 или 4 приема. Особые группы пациентов Пожилой возраст Коррекции режима дозирования не требуется. Дети Безопасность и эффективность применения препарата у детей в возрасте до 18 лет не установлены. Данные отсутствуют. Препарат подходит для проведения длительного курса лечения.
Побочные действия
При применении препарата в терапевтических дозах побочные эффекты обычно не выражены и носят преходящий характер. Возможные побочные эффекты при применении препарата Курантил приведены ниже по нисходящей частоте возникновения: часто (> 1/100, < 1/10), нечасто (> 1/1000, < 1/100), редко (> 1/10000, < 1/1000), очень редко (< 1/10000), частота неизвестна (невозможно оценить частоту, исходя из имеющихся данных). Нарушения со стороны крови и лимфатической системы Частота неизвестна: тромбоцитопения. Нарушения со стороны иммунной системы Редко: аллергические реакции, такие как преходящая кожная сыпь, крапивница; Нарушения со стороны нервной системы Нечасто: головокружение. Нарушения со стороны сердца Нечасто: тахикардия, снижение артериального давления (особенно при одновременном применении с другими вазодилататорами); Частота неизвестна: усиление проявлений ишемической болезни сердца, стенокардия, инфаркт миокарда. Нарушения со стороны сосудов Нечасто: ощущение жара (особенно у пациентов, принимающих другие сосудорасширяющие средства), головная боль, в том числе головная боль сосудистого происхождения; Частота неизвестна: повышение склонности к кровотечениям во время или после хирургических вмешательств. Нарушения со стороны дыхательной системы, органов грудной клетки и средостения Частота неизвестна: бронхоспазм. Нарушения со стороны желудочно-кишечного тракта Нечасто: рвота, диарея, тошнота. Нарушения со стороны печени и желчевыводящих путей Частота неизвестна: дипиридамол может входить в состав камней желчного пузыря. Нарушения со стороны скелетно-мышечной системы и соединительной ткани Нечасто: мышечная боль.
Фармакологическое действие
Дипиридамол подавляет агрегацию тромбоцитов, оказывает сосудорасширяющее действие, улучшает микроциркуляцию. Дипиридамол in vitro и in vivo тормозит поглощение аденозина эндотелиальными клетками, эритроцитами и тромбоцитами. Ингибирование захвата аденозина наблюдается при терапевтических концентрациях дипиридамола и носит дозозависимый характер. Возникающая при применении дипиридамола повышенная концентрация аденозина в плазме крови воздействует на А2-рецепторы тромбоцитов и стимулирует аденилатциклазу, тем самым повышая содержание в тромбоцитах циклического аденозинмонофосфата (цАМФ). В результате снижается агрегация тромбоцитов в ответ на различные стимулы (такие как фактор активации тромбоцитов, коллаген и АДФ) и уменьшается тромбообразование. Кроме того, аденозин воздействует на аденозиновые рецепторы сосудистой стенки и вызывает расширение сосудов (один из механизмов сосудорасширяющего действия дипиридамола). Дипиридамол ингибирует фосфодиэстеразы (ФДЭ) в различных тканях. Ингибирование цАМФ-ФДЭ является слабым, однако дипиридамол в терапевтических концентрациях ингибирует цГМФ-ФДЭ, тем самым увеличивая содержание в клетках циклического гуанозинмонофосфата (цГМФ), продуцируемого эндотелиальным релаксирующим фактором (идентифицированный как оксид азота [NO]). Дипиридамол также стимулирует биосинтез и высвобождение простациклина (PgI₂) эндотелием и снижает тромбогенность субэндотелиальных тканей за счет увеличения концентрации защитного медиатора 13-HODE (13-гидроксиоктадекадиеновая кислота). Было установлено, что дипиридамол нормализует сокращенное время жизни тромбоцитов. Дипиридамол не влияет на время кровотечения. Фармакокинетика Абсорбция При приеме внутрь дипиридамол быстро всасывается в желудочно-кишечном тракте: большая часть в желудке и частично в тонкой кишке. Биодоступность составляет 37-66%, время достижения максимальной концентрации в плазме крови около 2 часов. Распределение Дипиридамол почти полностью связывается с белками плазмы крови. После приема внутрь наблюдается двухфазный характер уменьшения концентрации дипиридамола в плазме крови. Метаболизм Дипиридамол метаболизируется в печени путем связывания с глюкуроновой кислотой. Выведение Период полувыведения в начальной фазе составляет 20-30 минут, а в конечной фазе выведения – 10 - 12 часов. Выделяется преимущественно в желчь и выводится через кишечник в виде моноглюкуронида. Наибольшее количество дипиридамола (1-3%) выводится почками.
Фармакологическая группа
антитромботическое средство
Форма выпуска
таблетки
Способ применения/введения
пероральный
Условия хранения
При температуре не выше 25 °С.Лекарственное средство хранить в недоступном для детей месте!
Передозировка
Симптомы: генерализованное расширение сосудов, сопровождающееся снижением артериального давления, жалобы, характерные для приступа стенокардии, тахикардия, чувство жара, ощущение «приливов», слабость, беспокойство и головокружение. Лечение: симптоматическая терапия, применяемая при пероральном отравлении: вызывание рвоты, промывание желудка, меры для уменьшения всасывания. Нежелательное вазодилатирующее действие препарата можно купировать медленным (50-100 мг/мин) внутривенным введением аминофиллина. В случае если жалобы, характерные для стенокардии, сохраняются, возможно применение нитроглицерина сублингвально.
Применение при беременности и кормлении грудью
Беременность Адекватных и хорошо контролируемых исследований у беременных не проводилось. Исследования на животных не выявили тератогенного или фетотоксического эффекта дипиридамола. Применение препарата во время беременности, особенно в первом триместре, возможно только в том случае, если ожидаемая польза для матери превышает возможный риск для плода. Период грудного вскармливания Исследования на животных показали, что дипиридамол в небольших количествах выделяется с грудным молоком. Применение препарата в период грудного вскармливания возможно только в том случае, если ожидаемая польза для матери превышает возможный риск для ребенка. Фертильность Исследования влияния дипиридамола на фертильность человека не проводились. Доклинические исследования не выявили прямого или косвенного вредного воздействия дипиридамола на фертильность животных.
Влияние на способность управлять транспортом и механизмами
При применении препарата Курантил® N 25 снижение артериального давления может приводить к изменению психомоторной реакции и нарушению способности к вождению транспортных средств и обслуживанию механизмов.
Особые указания
С осторожностью: Артериальная гипотензия, ишемическая болезнь сердца, бронхиальная астма, хроническая обструктивная болезнь легких, пациенты пожилого возраста (дипиридамол может вызвать артериальную гипотензию).
Взаимодействие
Производные ксантина (например, аминофиллин, теофиллин, кофеин, кофе, чай) могут ослаблять сосудорасширяющее действие дипиридамола. Дипиридамол при одновременном применении может усиливать действие антикоагулянтов и тромболитических препаратов и увеличивать риск кровотечений. Установлено аддитивное влияние ацетилсалициловой кислоты и дипиридамола на функцию тромбоцитов. Одновременное применение дипиридамола с ацетилсалициловой кислотой не увеличивает частоту кровотечений. Дипиридамол может усиливать действие лекарственных препаратов, снижающих артериальное давление. Дипиридамол может ослаблять действие ингибиторов холинэстеразы. Это следует принимать во внимание при лечении пациентов с миастенией gravis. Применение дипиридамола в сочетании с индометацином может привести к задержке жидкости. Дипиридамол ингибирует обратный захват аденозина клетками, вызывая увеличение концентрации аденозина в плазме и усиление сердечно-сосудистых эффектов (риск возникновения АВ-блокады, брадикардии и желудочковых экстрасистол). Фармакокинетические взаимодействия Антациды снижают максимальную концентрацию дипиридамола из-за снижения абсорбции и могут уменьшать эффекты дипиридамола. Индукторы ферментов микросомального окисления, такие как фенитоин, могут увеличивать клиренс дипиридамола. Дипиридамол может снижать всасывание флударабина и снижать его эффективность. Дипиридамол может незначительно повышать всасывание дигоксина.
Регистрационный номер
П N013897/01
Дата государственной регистрации
30.03.2021
Бренд
Берлин-Фарма/Берлин-Хеми АГ
Изготовитель
Berlin-Chemie
Страна бренда
Россия
Страна-производитель
Германия
Название препарата
Курантил
Срок годности
36 мес.
Сертификат лекарственного препарата
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– Вторичная профилактика ишемического инсульта и транзиторной ишемической атаки (в сочетании с ацетилсалициловой кислотой в низких дозах или в виде монотерапии при непереносимости ацетилсалициловой кислоты). – В качестве дополнения к пероральным антикоагулянтам непрямого действия для профилактики послеоперационных тромбоэмболических осложнений после замены сердечного клапана.
– повышенная чувствительность к компонентам препарата;
– наследственная непереносимость галактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция;
– острый инфаркт миокарда;
– нестабильная стенокардия;
– распространенный стенозирующий атеросклероз коронарных артерий;
– субаортальный стеноз;
– декомпенсированная сердечная недостаточность;
– выраженная артериальная гипотензия;
– коллапс;
– тяжелая артериальная гипертензия;
– тяжелые нарушения сердечного ритма;
– геморрагические диатезы;
– заболевания со склонностью к кровотечениям (язвенная болезнь желудка и двенадцатиперстной кишки и др.);
– детский возраст до 18 лет (эффективность и безопасность не установлены).
Внутрь, натощак, запивая небольшим количеством воды, не разламывая и не разжевывая. Доза препарата подбирается в зависимости от показаний, тяжести заболевания и реакции пациента на лечение. Длительность курса лечения определяется врачом.
Вторичная профилактика ишемического инсульта и транзиторной ишемической атаки (в сочетании с ацетилсалициловой кислотой в низких дозах или в виде монотерапии при непереносимости ацетилсалициловой кислоты)
Рекомендуемая доза дипиридамола составляет 300-600 мг в сутки, разделенная на 3 или 4 приема.
В качестве дополнения к пероральным антикоагулянтам непрямого действия для профилактики послеоперационных тромбоэмболических осложнений после замены сердечного клапана.
Рекомендуемая доза дипиридамола составляет 300-600 мг в сутки, разделенная на 3 или 4 приема.
Особые группы пациентов
Пожилой возраст
Коррекции режима дозирования не требуется.
Дети
Безопасность и эффективность применения препарата у детей в возрасте до 18 лет не установлены. Данные отсутствуют.
Препарат подходит для проведения длительного курса лечения.

Отзывы

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Покупатели пока не оставили отзывы
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Войдите в аккаунтИ тогда откроется корзина, а цены на Маркете могут стать ниже
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