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Для достижения оптимального увлажнения при ингаляциях препарат смешивают с 0,9 % раствором натрия хлорида в соотношении 1:1. Поскольку при ингаляционной терапии глубокий вдох может спровоцировать кашель, ингаляции следует проводить в режиме обычного дыхания. Перед ингаляцией обычно рекомендуется подогреть ингаляционный раствор до температуры тела. Больным с бронхиальной астмой рекомендуется проводить ингаляцию после приема бронхолитических препаратов, во избежание неспецифического раздражения дыхательных путей и их спазма.\u003Cbr\u003EВ случае сохранения симптомов заболевания в течении 4-5 дней от начала приема рекомендуется обратиться к врачу."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Нарушения со стороны желудочно-кишечного тракта: Часто (1,0 - 10,0 %) - тошнота, снижение чувствительности в полости рта или глотке; Нечасто (0,1 - 1,0 %) - диспепсия, рвота, диарея, абдоминальная боль, сухость во рту; Редко (0,01 - 0,1 %) - сухость в горле.\u003Cbr\u003EРасстройства иммунной системы, поражения кожи и подкожных тканей: Редко (0,01 - 0,1 %) - кожная сыпь, крапивница; анафилактические реакции (включая анафилактический шок), ангионевротический отек, зуд, гиперчувствительность.\u003Cbr\u003EРасстройства со стороны нервной системы: Часто (1,0 - 10,0 %) - дисгевзия (нарушение вкусовых ощущений)."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"В исследованиях показано, что амброксол - активный ингредиент Лазолвана - увеличивает секрецию в дыхательных путях. 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Несмотря на то, что нежелательные эффекты у детей, получающих кормление грудью, не наблюдались, в период лактации не рекомендуется использовать Лазолван раствор для приема внутрь и ингаляций.\u003Cbr\u003EДоклинические исследования амброксола не выявили отрицательного воздействия на фертильность."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Не было выявлено случаев влияния препарата на способность управлять транспортными средствами и механизмами. Исследования по влиянию препарата на способность управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций не проводились."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Не следует комбинировать с противокашлевыми средствами, затрудняющими выведение мокроты.\u003Cbr\u003EРаствор содержит консервант бензалкония хлорид, который при ингаляции может вызвать спазм бронхов у чувствительных пациентов с повышенной реактивностью дыхательных путей.\u003Cbr\u003EЛазолван раствор для приема внутрь и ингаляций не рекомендуется смешивать с кромоглициевой кислотой и щелочными растворами. Повышение значения pH раствора выше 6,3 может вызвать выпадение осадка амброксола гидрохлорида или появление опалесценции.\u003Cbr\u003EПациентам, соблюдающим гипонатриевую диету, необходимо принимать во внимание, что Лазолван раствор для приема внутрь и ингаляций содержит 42,8 мг натрия в рекомендованной суточной дозе (12 мл) для взрослых и детей старше 12 лет.\u003Cbr\u003EИмеются единичные сообщения о тяжелых поражениях кожи, таких как синдром Стивенса-Джонсона и токсический эпидермальный некролиз, совпавшие по времени с назначением отхаркивающих препаратов, таких как амброксола гидрохлорид. В большинстве случаев они могут быть объяснены тяжестью основного заболевания и/или сопутствующей терапией. У пациентов с синдромом Стивенса-Джонсона или токсическим эпидермальным некролизом в ранней фазе могут появляться температура, боль в теле, ринит, кашель и боль в горле. При симптоматическом лечении возможно ошибочное назначение противопростудных средств. При появлении новых поражений кожи и слизистых рекомендуется прекратить лечение амброксолом и немедленно обратиться за медицинской.\u003Cbr\u003EПри нарушении функции почек Лазолван необходимо применять только по рекомендации врача."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"О клинически значимых, нежелательных взаимодействиях с другими лекарственными средствами не сообщалось. 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Он усиливает продукцию легочного сурфактанта и стимулирует цилиарную активность. Эти эффекты приводят к усилению тока и транспорта слизи (мукоцилиарного клиренса). Усиление мукоцилиарного клиренса улучшает отхождение мокроты и облегчает кашель. У пациентов с хронической обструктивной болезнью легких длительная терапия Лазолваном (на протяжении не менее 2 месяцев) приводила к значительному снижению числа обострений. 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Доклинические исследования не выявили прямого или косвенного неблагоприятного влияния на беременность, эмбриональное/фетальное, постнатальное развитие и на родовую деятельность.\u003Cbr\u003EОбширный клинический опыт применения амброксола после 28-ой недели беременности не обнаружил свидетельств отрицательного влияния препарата на плод.\u003Cbr\u003EТем не менее необходимо соблюдать обычные меры предосторожности при использовании лекарства во время беременности. Особенно не рекомендуется принимать Лазолван в I триместре беременности. Во II и III триместрах беременности применение препарата возможно только в том случае, если потенциальная польза для матери превышает потенциальный риск для плода.\u003Cbr\u003EАмброксол может экскретироваться с грудным молоком. Несмотря на то, что нежелательные эффекты у детей, получающих кормление грудью, не наблюдались, в период лактации не рекомендуется использовать Лазолван раствор для приема внутрь и ингаляций.\u003Cbr\u003EДоклинические исследования амброксола не выявили отрицательного воздействия на фертильность."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Не было выявлено случаев влияния препарата на способность управлять транспортными средствами и механизмами. Исследования по влиянию препарата на способность управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций не проводились."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Не следует комбинировать с противокашлевыми средствами, затрудняющими выведение мокроты.\u003Cbr\u003EРаствор содержит консервант бензалкония хлорид, который при ингаляции может вызвать спазм бронхов у чувствительных пациентов с повышенной реактивностью дыхательных путей.\u003Cbr\u003EЛазолван раствор для приема внутрь и ингаляций не рекомендуется смешивать с кромоглициевой кислотой и щелочными растворами. Повышение значения pH раствора выше 6,3 может вызвать выпадение осадка амброксола гидрохлорида или появление опалесценции.\u003Cbr\u003EПациентам, соблюдающим гипонатриевую диету, необходимо принимать во внимание, что Лазолван раствор для приема внутрь и ингаляций содержит 42,8 мг натрия в рекомендованной суточной дозе (12 мл) для взрослых и детей старше 12 лет.\u003Cbr\u003EИмеются единичные сообщения о тяжелых поражениях кожи, таких как синдром Стивенса-Джонсона и токсический эпидермальный некролиз, совпавшие по времени с назначением отхаркивающих препаратов, таких как амброксола гидрохлорид. В большинстве случаев они могут быть объяснены тяжестью основного заболевания и/или сопутствующей терапией. У пациентов с синдромом Стивенса-Джонсона или токсическим эпидермальным некролизом в ранней фазе могут появляться температура, боль в теле, ринит, кашель и боль в горле. При симптоматическом лечении возможно ошибочное назначение противопростудных средств. При появлении новых поражений кожи и слизистых рекомендуется прекратить лечение амброксолом и немедленно обратиться за медицинской.\u003Cbr\u003EПри нарушении функции почек Лазолван необходимо применять только по рекомендации врача."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"О клинически значимых, нежелательных взаимодействиях с другими лекарственными средствами не сообщалось. 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