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Описание

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Листата таб. п/о плен., 120 мг, 80 шт.

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4.7
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Количество штук в упаковке, шт.: 80

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Коротко о товаре

Артикул Маркета
4453139715
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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синдром хронической мальабсорбции; холестаз; беременность, период грудного вскармливания; детский возраст до 12 лет."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой содержит:\u003Cbr /\u003EСостав ядра таблетки:\u003Cbr /\u003EДействующее вещество: орлистат - 120,0 мг;\u003Cbr /\u003EВспомогательные вещества: натрия лаурилсульфат - 12,0 мг; акации камедь - 210,0 мг; маннитол - 580,0 мг; коповидон - 20,0 мг; кросповидон - 50,0 мг; магния стеарат - 8,0 мг.\u003Cbr /\u003EСостав оболочки таблетки:\u003Cbr /\u003EОпадрай II голубой (85F205040) - 34,0 мг (поливиниловый спирт - 40,0%, титана диоксид - 22,48%, макрогол 3350 - 20,20%, тальк - 14,80%, лак алюминиевый голубой - 2,28%, краситель железа оксид желтый - 0,24%).\u003Cbr /\u003E"},{"name":"Действующее вещество","value":"Орлистат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28710734"]}}},{"name":"Способ применения и дозы","value":"Внутрь, запивая водой.\u003Cbr\u003EЛечение пациентов с ожирением при ИМТ не менее 30 кг/м2 или пациентов с избыточной массой тела при ИМТ не менее 28 кг/ м2, в том числе имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно низкокалорийной диетой.\u003Cbr\u003EВзрослые и дети старше 12 лет\u003Cbr\u003EРекомендованная доза препарата Листата - 1 таблетка (120 мг) с каждым основным приемом пищи (во время еды или не позднее чем через 1 час после еды).\u003Cbr\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сулъфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением.\u003Cbr\u003EВзрослые\u003Cbr\u003EРекомендуемая доза препарата Листата 1 таблетка (120 мг) с каждым основным приемом пищи (во время еды или не позднее чем через 1 час после еды).\u003Cbr\u003EЕсли прием пищи пропускают или если пища не содержит жира, то прием препарата Листата также можно пропустить.\u003Cbr\u003EПрепарат Листата следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять между 3 основными приемами пищи.\u003Cbr\u003EУвеличение дозы препарата Листата свыше рекомендованной (120 мг 3 раза в день) не приводит к усилению его терапевтического эффекта.\u003Cbr\u003EЭффективность и безопасность препарата Листата у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого возраста и детей до 12 лет не исследовались."},{"name":"Побочные действия","value":"Побочные действия препарата систематизированы относительно каждой из систем органов в зависимости от частоты встречаемости, с использованием следующей классификации: очень часто (более 1/10); часто (более 1/100, менее 1/10); нечасто (более 1/1000, менее 1/100); редко (более 1/10000, менее 1/1000); очень редко, включая единичные сообщения (менее 1/10000).\u003Cbr\u003EПобочные реакции при применении орлистата возникали, главным образом, со стороны желудочно-кишечного тракта (ЖКТ) и были обусловлены фармакологическим действием орлистата, препятствующего всасыванию жиров пищи. Очень часто отмечались такие явления, как маслянистые выделения из прямой кишки, выделение газов с некоторым количеством отделяемого, императивные позывы на дефекацию, стеаторея, учащение дефекации, жидкий стул, метеоризм, боль или дискомфорт в животе. Их частота увеличивается при повышении содержания жира в пище. Пациентов следует информировать о возможности возникновения побочных реакций со стороны ЖКТ и обучить, как устранять их соблюдением диеты, особенно в отношении количества содержащегося в ней жира. Применение диеты с низким содержанием жира уменьшает вероятность побочных действий со стороны ЖКТ и тем самым помогает пациентам контролировать и регулировать потребление жиров.\u003Cbr\u003EКак правило, указанные побочные реакции являются слабо выраженными и транзиторными. Они возникают на ранних этапах лечения (в первые 3 месяца), причем у большинства пациентов было не более одного эпизода таких реакций.\u003Cbr\u003EПри лечении орлистатом часто возникают следующие нежелательные явления со стороны ЖКТ: \"мягкий\" стул, боль или дискомфорт в прямой кишке, недержание кала, вздутие живота, поражение зубов, поражение десен.\u003Cbr\u003EОтмечались также очень часто: головная боль, инфекции верхних дыхательных путей, грипп; часто: инфекции нижних дыхательных путей, инфекции мочевыводящих путей, дисменорея, тревога, слабость.\u003Cbr\u003EУ пациентов с сахарным диабетом 2 типа характер и частота нежелательных явлений были сопоставимы с таковыми у лиц без сахарного диабета с избыточной массой тела и ожирением.\u003Cbr\u003EЕдинственными новыми побочными явлениями у пациентов с сахарным диабетом 2 типа были гипогликемические состояния, возникавшие с частотой более 2% и инцидентностью не менее 1% по сравнению с плацебо (которые могли возникать в результате улучшения компенсации углеводного обмена), и часто - вздутие живота.\u003Cbr\u003EВ 4-летнем клиническом исследовании общий профиль безопасности не отличался от такового, полученного в 1- и 2-летних исследованиях. При этом общая частота возникновения нежелательных явлений со стороны ЖКТ ежегодно уменьшалась на протяжении 4-летнего периода приема препарата.\u003Cbr\u003EПостмаркетинговое наблюдение\u003Cbr\u003EОписаны редкие случаи аллергических реакций, главными клиническими проявлениями которых были кожная сыпь, зуд, крапивница, ангионевротический отек, бронхоспазм и анафилаксия.\u003Cbr\u003EОписаны очень редкие случаи буллезной сыпи, повышения активности трансаминаз и щелочной фосфатазы, а также отдельные, возможно серьезные, случаи развития гепатита (причинно-следственная связь с приемом орлистата или патофизиологические механизмы развития не установлены).\u003Cbr\u003EПри одновременном применении орлистата с антикоагулянтами непрямого действия зарегистрированы случаи снижения протромбина, увеличение значений международного нормализованного отношения (МНО) и несбалансированной терапии антикоагулянтами, что приводило к изменению гемостатических параметров.\u003Cbr\u003EЗарегистрированы случаи ректального кровотечения, дивертикулита, панкреатита, холелитиаза и оксалатной нефропатии (частота возникновения не известна).\u003Cbr\u003EПри одновременном приеме орлистата и противоэпилептических препаратов наблюдались случаи развития судорог (см. раздел \"Взаимодействие с другими лекарственными средствами\")."},{"name":"Фармакологическое действие","value":"Орлистат - мощный, специфический и обратимый ингибитор желудочно- кишечных липаз, обладающий продолжительным действием. Его терапевтическое действие осуществляется в просвете желудка и тонкого кишечника и заключается в образовании ковалентной связи с активным сериновым участком желудочной и панкреатической липаз.\u003Cbr\u003EИнактивированный фермент при этом теряет способность расщеплять жиры пищи, поступающие в форме триглицеридов, на всасывающиеся свободные жирные кислоты и моноглицериды. Поскольку нерасщепленные триглицериды не всасываются, возникающее вследствие этого уменьшение поступления калорий в организм приводит к уменьшению массы тела. Таким образом, терапевтическое действие препарата осуществляется без всасывания в системный кровоток.\u003Cbr\u003EСудя по результатам содержания жира в кале, действие орлистата начинается через 24-48 часов после приема. После отмены орлистата содержание жира в кале через 48-72 часа обычно возвращается к уровню, имевшему место до начала терапии.\u003Cbr\u003EКлиническая эффективность\u003Cbr\u003EУ пациентов, принимающих орлистат, наблюдается большая потеря массы тела по сравнению с пациентами, находящимися на диетотерапии. Снижение массы тела начинается уже в течение первых 2-х недель после начала лечения и продолжается от 6 до 12 месяцев даже у пациентов с отрицательным ответом на диетотерапию. На протяжении 2-х лет наблюдается статистически значимое улучшение профиля метаболических факторов риска, сопутствующих ожирению. Кроме того, по сравнению с приемом плацебо отмечается значительное уменьшение количества жира в организме. Орлистат эффективен в отношении предотвращения повторной прибавки массы тела. Повторный набор массы тела, не более 25% от потерянной, наблюдается примерно у половины пациентов, а у половины из этих пациентов повторного набора массы тела не наблюдается или даже отмечается дальнейшее ее снижение.\u003Cbr\u003EУ пациентов с избыточной массой тела или ожирением и сахарным диабетом 2 типа, принимающих орлистат в течение от 6 месяцев до 1 года, наблюдается большая потеря массы тела по сравнению с пациентами, получающими только диетотерапию. Потеря массы тела происходит в основном за счет уменьшения количества жира в организме. При проведении терапии орлистатом наблюдается статистически и клинически значимое улучшение контроля гликемии. Кроме того, на фоне терапии орлистатом наблюдается снижение дозы гипогликемических средств, концентрации инсулина, а также уменьшение инсулинорезистентности.\u003Cbr\u003EПри применении орлистата в течение 4 лет значительно снижается риск развития сахарного диабета 2 типа (примерно на 37% по сравнению с плацебо). Степень уменьшения риска даже более значительна у пациентов с исходным нарушением толерантности к глюкозе (приблизительно на 45%).\u003Cbr\u003EПоддержание массы тела на новом уровне наблюдается в течение всего периода применения препарата.\u003Cbr\u003EПри применении орлистата в течение 1 года у подростков с ожирением наблюдается уменьшение индекса массы тела, уменьшение жировой массы, а также окружности талии и бедер по сравнению с группой плацебо. Также у пациентов, получавших терапию орлистатом, отмечается значительное снижение диастолического артериального давления по сравнению с группой плацебо."},{"name":"Фармакологическая группа","value":"ингибиторы липазы ЖКТ"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"У лиц с нормальной массой тела и пациентов с ожирением прием разовых доз 800 мг или многократный прием орлистата по 400 мг 3 раза в сутки в течение 15 дней не сопровождался появлением существенных нежелательных явлений. Кроме того, у пациентов с ожирением есть опыт применения орлистата по 240 мг 3 раза в сутки в течение 6 мес, что не сопровождалось достоверным увеличением частоты нежелательных явлений.\u003Cbr\u003EВ случаях передозировки орлистата сообщалось либо об отсутствии нежелательных явлений, либо нежелательные явления не отличались от тех, которые наблюдаются при приеме орлистата в терапевтических дозах.\u003Cbr\u003EВ случае выраженной передозировки орлистата рекомендуется наблюдать пациента в течение 24 ч. По данным исследований у человека и животных, любые системные эффекты, которые можно было бы связать с липазоингибирующими свойствами орлистата, должны быть быстро обратимы."},{"name":"Применение при беременности и кормлении грудью","value":"В исследованиях репродуктивной токсичности на животных тератогенного и эмбриотоксического эффекта препарата орлистата не наблюдалось. В отсутствие тератогенного эффекта у животных подобный эффект у человека не ожидается. Поскольку отсутствуют клинические данные о применении орлистата во время беременности, применение препарата Листата у беременных женщин противопоказано.\u003Cbr\u003EВ связи с тем, что отсутствуют данные о выделении орлистата с грудным молоком, применение препарата Листата в период грудного вскармливания противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат Листата не влияет на способность управлять транспортными средствами и механизмами. Пациенты с сахарным диабетом 2 типа, применяющие препарат Листата в комбинации с гипогликемическими препаратами, должны соблюдать осторожность при управлении транспортными средствами и механизмами в связи с возможным развитием гипогликемии, сопровождающейся головокружением, нарушением зрения."},{"name":"Особые указания","value":"Препарат Листата эффективен в плане длительного контроля массы тела (снижение массы тела и ее поддержание, предотвращение повторной прибавки массы тела). Лечение препаратом Листата приводит к улучшению профиля факторов риска и заболеваний, сопутствующих ожирению, включая гиперхолестеринемию, сахарный диабет 2 типа, нарушение толерантности к глюкозе, гиперинсулинемию, артериальную гипертензию, и к уменьшению количества висцерального жира.\u003Cbr\u003EПри применении в комбинации с такими гипогликемическими препаратами, как метформин, производные сульфонилмочевины и/или инсулин у пациентов с сахарным диабетом 2 типа с избыточной массой тела (ИМТ не менее 28 кг/м2 ) или ожирением (ИМТ не менее 30 кг/м2), препарат Листата в сочетании с умеренно гипокалорийной диетой способствует дополнительному улучшению компенсации углеводного обмена.\u003Cbr\u003EВ клинических исследованиях у большинства пациентов концентрации витаминов A, D, Е, К и бета-каротина в ходе четырех лет терапии орлистатом оставались в пределах нормы. Для обеспечения адекватного поступления всех минеральных веществ можно применять поливитамины.\u003Cbr\u003EПациент должен получать сбалансированную, умеренно гипокалорийную диету, содержащую не более 30% калоража в виде жиров. Рекомендуется питание, богатое фруктами и овощами. Суточное потребление жиров, углеводов и белков необходимо распределять на три основных приема. Вероятность побочных реакций со стороны ЖКТ может увеличиваться, если препарат Листата принимают на фоне питания, богатого жирами (например, 2000 ккал/сут, из них более 30% в виде жиров, что равняется примерно 67 г жира). Если препарат Листата принимают с пищей, очень богатой жиром, вероятность желудочно-кишечных реакций увеличивается.\u003Cbr\u003EУ пациентов с сахарным диабетом 2 типа уменьшение массы тела при лечении препаратом Листата сопровождается улучшением компенсации углеводного обмена, что может позволить или потребовать снижения дозы гипогликемических препаратов (например, производных сульфонилмочевины)."},{"name":"Взаимодействие","value":"Не выявлено взаимодействия орлистата с амитриптилином, аторвастатином, бигуанидами, дигоксином, фибратами, флуоксетином, лозартаном, фенитоином, пероральными контрацептивами, фентермином, правастатином, варфарином, нифедипином ГИТС (гастро-интестинальная терапевтическая система) и нифедипином с медленным высвобождением, сибутрамином или этанолом (на основании исследований взаимодействий между лекарственными средствами). Однако необходимо следить за показателями МНО при одновременной терапии варфарином или другими антикоагулянтами непрямого действия.\u003Cbr\u003EПри одновременном приеме с орлистатом отмечалось уменьшение всасывания витаминов D, Е и бета-каротина. Если рекомендованы поливитамины, их следует принимать не менее чем через 2 ч после приема орлистата или перед сном.\u003Cbr\u003EПри одновременном приеме орлистата и циклоспорина отмечалось снижение концентрации циклоспорина в плазме крови, поэтому рекомендуется более частое определение концентрации циклоспорина в плазме крови при одновременном приеме циклоспорина и орлистата.\u003Cbr\u003EПри приеме внутрь амиодарона во время терапии орлистатом отмечалось снижение системной экспозиции амиодарона и дезэтиламиодарона (на 25- 30%), однако в связи со сложной фармакокинетикой амиодарона, клиническая значимость этого явления не ясна. Добавление орлистата к длительной терапии амиодароном возможно приведет к снижению терапевтического эффекта амиодарона (исследований не проводилось).\u003Cbr\u003EСледует избегать одновременного приема орлистата и акарбозы из-за отсутствия данных фармакокинетических исследований.\u003Cbr\u003EПри одновременном приеме орлистата и противоэпилептических препаратов наблюдались случаи развития судорог. Причинно-следственная связь между развитием судорог и терапией орлистатом не установлена. Тем не менее следует мониторировать состояние пациентов на предмет возможных изменений частоты и/или тяжести судорожного синдрома."},{"name":"Регистрационный номер","value":"ЛП-002174"},{"name":"Дата государственной регистрации","value":"27.01.2021"},{"name":"Владелец регистрационного удостоверения","value":"Изварино Фарма","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:17847894"]}}},{"name":"Изготовитель","value":"Изварино Фарма"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Листата","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18008610"]}}},{"name":"Срок годности","value":"23 мес."}]}},"fullSpecsGrouped":{"6714919025903106552":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"желудочно-кишечный тракт, пищеварительная система"},{"name":"Назначение","value":"алиментарное ожирение, избыточная масса тела, похудение"},{"name":"Показания к применению","value":"Длительная терапия пациентов с ожирением при индексе массы тела (ИМТ) не менее 30 кг/м2 или пациентов с избыточной массой тела при ИМТ не менее 28 кг/м2 , в том числе имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой.\u003Cbr\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением."},{"name":"Противопоказания","value":"Повышенная чувствительность к орлистату или любым другим компонентам препарата; синдром хронической мальабсорбции; холестаз; беременность, период грудного вскармливания; детский возраст до 12 лет."},{"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой содержит:\u003Cbr /\u003EСостав ядра таблетки:\u003Cbr /\u003EДействующее вещество: орлистат - 120,0 мг;\u003Cbr /\u003EВспомогательные вещества: натрия лаурилсульфат - 12,0 мг; акации камедь - 210,0 мг; маннитол - 580,0 мг; коповидон - 20,0 мг; кросповидон - 50,0 мг; магния стеарат - 8,0 мг.\u003Cbr /\u003EСостав оболочки таблетки:\u003Cbr /\u003EОпадрай II голубой (85F205040) - 34,0 мг (поливиниловый спирт - 40,0%, титана диоксид - 22,48%, макрогол 3350 - 20,20%, тальк - 14,80%, лак алюминиевый голубой - 2,28%, краситель железа оксид желтый - 0,24%).\u003Cbr /\u003E"},{"name":"Действующее вещество","value":"Орлистат"},{"name":"Способ применения и дозы","value":"Внутрь, запивая водой.\u003Cbr\u003EЛечение пациентов с ожирением при ИМТ не менее 30 кг/м2 или пациентов с избыточной массой тела при ИМТ не менее 28 кг/ м2, в том числе имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно низкокалорийной диетой.\u003Cbr\u003EВзрослые и дети старше 12 лет\u003Cbr\u003EРекомендованная доза препарата Листата - 1 таблетка (120 мг) с каждым основным приемом пищи (во время еды или не позднее чем через 1 час после еды).\u003Cbr\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сулъфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением.\u003Cbr\u003EВзрослые\u003Cbr\u003EРекомендуемая доза препарата Листата 1 таблетка (120 мг) с каждым основным приемом пищи (во время еды или не позднее чем через 1 час после еды).\u003Cbr\u003EЕсли прием пищи пропускают или если пища не содержит жира, то прием препарата Листата также можно пропустить.\u003Cbr\u003EПрепарат Листата следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять между 3 основными приемами пищи.\u003Cbr\u003EУвеличение дозы препарата Листата свыше рекомендованной (120 мг 3 раза в день) не приводит к усилению его терапевтического эффекта.\u003Cbr\u003EЭффективность и безопасность препарата Листата у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого возраста и детей до 12 лет не исследовались."},{"name":"Побочные действия","value":"Побочные действия препарата систематизированы относительно каждой из систем органов в зависимости от частоты встречаемости, с использованием следующей классификации: очень часто (более 1/10); часто (более 1/100, менее 1/10); нечасто (более 1/1000, менее 1/100); редко (более 1/10000, менее 1/1000); очень редко, включая единичные сообщения (менее 1/10000).\u003Cbr\u003EПобочные реакции при применении орлистата возникали, главным образом, со стороны желудочно-кишечного тракта (ЖКТ) и были обусловлены фармакологическим действием орлистата, препятствующего всасыванию жиров пищи. Очень часто отмечались такие явления, как маслянистые выделения из прямой кишки, выделение газов с некоторым количеством отделяемого, императивные позывы на дефекацию, стеаторея, учащение дефекации, жидкий стул, метеоризм, боль или дискомфорт в животе. Их частота увеличивается при повышении содержания жира в пище. Пациентов следует информировать о возможности возникновения побочных реакций со стороны ЖКТ и обучить, как устранять их соблюдением диеты, особенно в отношении количества содержащегося в ней жира. Применение диеты с низким содержанием жира уменьшает вероятность побочных действий со стороны ЖКТ и тем самым помогает пациентам контролировать и регулировать потребление жиров.\u003Cbr\u003EКак правило, указанные побочные реакции являются слабо выраженными и транзиторными. Они возникают на ранних этапах лечения (в первые 3 месяца), причем у большинства пациентов было не более одного эпизода таких реакций.\u003Cbr\u003EПри лечении орлистатом часто возникают следующие нежелательные явления со стороны ЖКТ: \"мягкий\" стул, боль или дискомфорт в прямой кишке, недержание кала, вздутие живота, поражение зубов, поражение десен.\u003Cbr\u003EОтмечались также очень часто: головная боль, инфекции верхних дыхательных путей, грипп; часто: инфекции нижних дыхательных путей, инфекции мочевыводящих путей, дисменорея, тревога, слабость.\u003Cbr\u003EУ пациентов с сахарным диабетом 2 типа характер и частота нежелательных явлений были сопоставимы с таковыми у лиц без сахарного диабета с избыточной массой тела и ожирением.\u003Cbr\u003EЕдинственными новыми побочными явлениями у пациентов с сахарным диабетом 2 типа были гипогликемические состояния, возникавшие с частотой более 2% и инцидентностью не менее 1% по сравнению с плацебо (которые могли возникать в результате улучшения компенсации углеводного обмена), и часто - вздутие живота.\u003Cbr\u003EВ 4-летнем клиническом исследовании общий профиль безопасности не отличался от такового, полученного в 1- и 2-летних исследованиях. При этом общая частота возникновения нежелательных явлений со стороны ЖКТ ежегодно уменьшалась на протяжении 4-летнего периода приема препарата.\u003Cbr\u003EПостмаркетинговое наблюдение\u003Cbr\u003EОписаны редкие случаи аллергических реакций, главными клиническими проявлениями которых были кожная сыпь, зуд, крапивница, ангионевротический отек, бронхоспазм и анафилаксия.\u003Cbr\u003EОписаны очень редкие случаи буллезной сыпи, повышения активности трансаминаз и щелочной фосфатазы, а также отдельные, возможно серьезные, случаи развития гепатита (причинно-следственная связь с приемом орлистата или патофизиологические механизмы развития не установлены).\u003Cbr\u003EПри одновременном применении орлистата с антикоагулянтами непрямого действия зарегистрированы случаи снижения протромбина, увеличение значений международного нормализованного отношения (МНО) и несбалансированной терапии антикоагулянтами, что приводило к изменению гемостатических параметров.\u003Cbr\u003EЗарегистрированы случаи ректального кровотечения, дивертикулита, панкреатита, холелитиаза и оксалатной нефропатии (частота возникновения не известна).\u003Cbr\u003EПри одновременном приеме орлистата и противоэпилептических препаратов наблюдались случаи развития судорог (см. раздел \"Взаимодействие с другими лекарственными средствами\")."},{"name":"Фармакологическое действие","value":"Орлистат - мощный, специфический и обратимый ингибитор желудочно- кишечных липаз, обладающий продолжительным действием. Его терапевтическое действие осуществляется в просвете желудка и тонкого кишечника и заключается в образовании ковалентной связи с активным сериновым участком желудочной и панкреатической липаз.\u003Cbr\u003EИнактивированный фермент при этом теряет способность расщеплять жиры пищи, поступающие в форме триглицеридов, на всасывающиеся свободные жирные кислоты и моноглицериды. Поскольку нерасщепленные триглицериды не всасываются, возникающее вследствие этого уменьшение поступления калорий в организм приводит к уменьшению массы тела. Таким образом, терапевтическое действие препарата осуществляется без всасывания в системный кровоток.\u003Cbr\u003EСудя по результатам содержания жира в кале, действие орлистата начинается через 24-48 часов после приема. После отмены орлистата содержание жира в кале через 48-72 часа обычно возвращается к уровню, имевшему место до начала терапии.\u003Cbr\u003EКлиническая эффективность\u003Cbr\u003EУ пациентов, принимающих орлистат, наблюдается большая потеря массы тела по сравнению с пациентами, находящимися на диетотерапии. Снижение массы тела начинается уже в течение первых 2-х недель после начала лечения и продолжается от 6 до 12 месяцев даже у пациентов с отрицательным ответом на диетотерапию. На протяжении 2-х лет наблюдается статистически значимое улучшение профиля метаболических факторов риска, сопутствующих ожирению. Кроме того, по сравнению с приемом плацебо отмечается значительное уменьшение количества жира в организме. Орлистат эффективен в отношении предотвращения повторной прибавки массы тела. Повторный набор массы тела, не более 25% от потерянной, наблюдается примерно у половины пациентов, а у половины из этих пациентов повторного набора массы тела не наблюдается или даже отмечается дальнейшее ее снижение.\u003Cbr\u003EУ пациентов с избыточной массой тела или ожирением и сахарным диабетом 2 типа, принимающих орлистат в течение от 6 месяцев до 1 года, наблюдается большая потеря массы тела по сравнению с пациентами, получающими только диетотерапию. Потеря массы тела происходит в основном за счет уменьшения количества жира в организме. При проведении терапии орлистатом наблюдается статистически и клинически значимое улучшение контроля гликемии. Кроме того, на фоне терапии орлистатом наблюдается снижение дозы гипогликемических средств, концентрации инсулина, а также уменьшение инсулинорезистентности.\u003Cbr\u003EПри применении орлистата в течение 4 лет значительно снижается риск развития сахарного диабета 2 типа (примерно на 37% по сравнению с плацебо). Степень уменьшения риска даже более значительна у пациентов с исходным нарушением толерантности к глюкозе (приблизительно на 45%).\u003Cbr\u003EПоддержание массы тела на новом уровне наблюдается в течение всего периода применения препарата.\u003Cbr\u003EПри применении орлистата в течение 1 года у подростков с ожирением наблюдается уменьшение индекса массы тела, уменьшение жировой массы, а также окружности талии и бедер по сравнению с группой плацебо. Также у пациентов, получавших терапию орлистатом, отмечается значительное снижение диастолического артериального давления по сравнению с группой плацебо."},{"name":"Фармакологическая группа","value":"ингибиторы липазы ЖКТ"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"У лиц с нормальной массой тела и пациентов с ожирением прием разовых доз 800 мг или многократный прием орлистата по 400 мг 3 раза в сутки в течение 15 дней не сопровождался появлением существенных нежелательных явлений. Кроме того, у пациентов с ожирением есть опыт применения орлистата по 240 мг 3 раза в сутки в течение 6 мес, что не сопровождалось достоверным увеличением частоты нежелательных явлений.\u003Cbr\u003EВ случаях передозировки орлистата сообщалось либо об отсутствии нежелательных явлений, либо нежелательные явления не отличались от тех, которые наблюдаются при приеме орлистата в терапевтических дозах.\u003Cbr\u003EВ случае выраженной передозировки орлистата рекомендуется наблюдать пациента в течение 24 ч. По данным исследований у человека и животных, любые системные эффекты, которые можно было бы связать с липазоингибирующими свойствами орлистата, должны быть быстро обратимы."},{"name":"Применение при беременности и кормлении грудью","value":"В исследованиях репродуктивной токсичности на животных тератогенного и эмбриотоксического эффекта препарата орлистата не наблюдалось. В отсутствие тератогенного эффекта у животных подобный эффект у человека не ожидается. Поскольку отсутствуют клинические данные о применении орлистата во время беременности, применение препарата Листата у беременных женщин противопоказано.\u003Cbr\u003EВ связи с тем, что отсутствуют данные о выделении орлистата с грудным молоком, применение препарата Листата в период грудного вскармливания противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат Листата не влияет на способность управлять транспортными средствами и механизмами. Пациенты с сахарным диабетом 2 типа, применяющие препарат Листата в комбинации с гипогликемическими препаратами, должны соблюдать осторожность при управлении транспортными средствами и механизмами в связи с возможным развитием гипогликемии, сопровождающейся головокружением, нарушением зрения."},{"name":"Особые указания","value":"Препарат Листата эффективен в плане длительного контроля массы тела (снижение массы тела и ее поддержание, предотвращение повторной прибавки массы тела). Лечение препаратом Листата приводит к улучшению профиля факторов риска и заболеваний, сопутствующих ожирению, включая гиперхолестеринемию, сахарный диабет 2 типа, нарушение толерантности к глюкозе, гиперинсулинемию, артериальную гипертензию, и к уменьшению количества висцерального жира.\u003Cbr\u003EПри применении в комбинации с такими гипогликемическими препаратами, как метформин, производные сульфонилмочевины и/или инсулин у пациентов с сахарным диабетом 2 типа с избыточной массой тела (ИМТ не менее 28 кг/м2 ) или ожирением (ИМТ не менее 30 кг/м2), препарат Листата в сочетании с умеренно гипокалорийной диетой способствует дополнительному улучшению компенсации углеводного обмена.\u003Cbr\u003EВ клинических исследованиях у большинства пациентов концентрации витаминов A, D, Е, К и бета-каротина в ходе четырех лет терапии орлистатом оставались в пределах нормы. Для обеспечения адекватного поступления всех минеральных веществ можно применять поливитамины.\u003Cbr\u003EПациент должен получать сбалансированную, умеренно гипокалорийную диету, содержащую не более 30% калоража в виде жиров. Рекомендуется питание, богатое фруктами и овощами. Суточное потребление жиров, углеводов и белков необходимо распределять на три основных приема. Вероятность побочных реакций со стороны ЖКТ может увеличиваться, если препарат Листата принимают на фоне питания, богатого жирами (например, 2000 ккал/сут, из них более 30% в виде жиров, что равняется примерно 67 г жира). Если препарат Листата принимают с пищей, очень богатой жиром, вероятность желудочно-кишечных реакций увеличивается.\u003Cbr\u003EУ пациентов с сахарным диабетом 2 типа уменьшение массы тела при лечении препаратом Листата сопровождается улучшением компенсации углеводного обмена, что может позволить или потребовать снижения дозы гипогликемических препаратов (например, производных сульфонилмочевины)."},{"name":"Взаимодействие","value":"Не выявлено взаимодействия орлистата с амитриптилином, аторвастатином, бигуанидами, дигоксином, фибратами, флуоксетином, лозартаном, фенитоином, пероральными контрацептивами, фентермином, правастатином, варфарином, нифедипином ГИТС (гастро-интестинальная терапевтическая система) и нифедипином с медленным высвобождением, сибутрамином или этанолом (на основании исследований взаимодействий между лекарственными средствами). Однако необходимо следить за показателями МНО при одновременной терапии варфарином или другими антикоагулянтами непрямого действия.\u003Cbr\u003EПри одновременном приеме с орлистатом отмечалось уменьшение всасывания витаминов D, Е и бета-каротина. Если рекомендованы поливитамины, их следует принимать не менее чем через 2 ч после приема орлистата или перед сном.\u003Cbr\u003EПри одновременном приеме орлистата и циклоспорина отмечалось снижение концентрации циклоспорина в плазме крови, поэтому рекомендуется более частое определение концентрации циклоспорина в плазме крови при одновременном приеме циклоспорина и орлистата.\u003Cbr\u003EПри приеме внутрь амиодарона во время терапии орлистатом отмечалось снижение системной экспозиции амиодарона и дезэтиламиодарона (на 25- 30%), однако в связи со сложной фармакокинетикой амиодарона, клиническая значимость этого явления не ясна. Добавление орлистата к длительной терапии амиодароном возможно приведет к снижению терапевтического эффекта амиодарона (исследований не проводилось).\u003Cbr\u003EСледует избегать одновременного приема орлистата и акарбозы из-за отсутствия данных фармакокинетических исследований.\u003Cbr\u003EПри одновременном приеме орлистата и противоэпилептических препаратов наблюдались случаи развития судорог. Причинно-следственная связь между развитием судорог и терапией орлистатом не установлена. Тем не менее следует мониторировать состояние пациентов на предмет возможных изменений частоты и/или тяжести судорожного синдрома."},{"name":"Регистрационный номер","value":"ЛП-002174"},{"name":"Дата государственной регистрации","value":"27.01.2021"},{"name":"Владелец регистрационного удостоверения","value":"Изварино Фарма"},{"name":"Изготовитель","value":"Изварино Фарма"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Листата"},{"name":"Срок годности","value":"23 мес."}]}],"transitionId":"tr_16570444397121602682"}}}}
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    С картой  Пэй
    Цена с картой Яндекс Пэй 708 ₽ вместо 715
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  • Голдлайн плюс капс., 15мг+153,5мг, 30 шт., 1 уп.
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    Голдлайн плюс капс., 15мг+153,5мг, 30 шт., 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 257 оценок
    Цена 2 809 ₽
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  • Орсотен Слим капс., 60 мг, 42 шт.
    –2 %
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    Орсотен Слим капс., 60 мг, 42 шт.

    Рейтинг товара: 4.1 из 5
    на основе 17 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 337 ₽ вместо 1 365
    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Слим капс., 60 мг, 42 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  • Орлистат-Акрихин капс., 60 мг, 42 шт.
    –1 %
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    Орлистат-Акрихин капс., 60 мг, 42 шт.

    Рейтинг товара: 4.6 из 5
    на основе 73 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 817 ₽ вместо 825
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  • Орлистат-акрихин капс., 120 мг, 84 шт.
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    Орлистат-акрихин капс., 120 мг, 84 шт.

    Рейтинг товара: 4.9 из 5
    на основе 47 оценок
    Цена 3 185 ₽
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  • Редуксин капс., 10 мг+158.5 мг, 30 шт.
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    Редуксин капс., 10 мг+158.5 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 22 оценки
    Цена 2 749 ₽
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  • Орсотен капс., 120 мг, 21 шт.
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    Орсотен капс., 120 мг, 21 шт.

    Рейтинг товара: 4.7 из 5
    на основе 30 оценок
    Цена 1 035 ₽
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  • Орлистат-акрихин капс., 120 мг, 42 шт.
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    Орлистат-акрихин капс., 120 мг, 42 шт.

    Рейтинг товара: 5 из 5
    на основе 10 оценок
    Цена 1 689 ₽
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  • Редуксин Форте таб. п/о плен., 850 мг+10 мг, 30 шт.
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    Редуксин Форте таб. п/о плен., 850 мг+10 мг, 30 шт.

    Рейтинг товара: 4.3 из 5
    на основе 13 оценок
    Цена 2 679 ₽
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  • Ксеникал капс., 120 мг, 21 шт.
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    Ксеникал капс., 120 мг, 21 шт.

    Рейтинг товара: 4.8 из 5
    на основе 27 оценок
    Цена 1 012 ₽
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  • Ксеникал капс., 120 мг, 84 шт.
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    Ксеникал капс., 120 мг, 84 шт.

    Рейтинг товара: 4.6 из 5
    на основе 33 оценки
    Цена 3 570 ₽
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Инструкция

Показания к применению

Длительная терапия пациентов с ожирением при индексе массы тела (ИМТ) не менее 30 кг/м2 или пациентов с избыточной массой тела при ИМТ не менее 28 кг/м2 , в том числе имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой.
В комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением.

Противопоказания

Повышенная чувствительность к орлистату или любым другим компонентам препарата; синдром хронической мальабсорбции; холестаз; беременность, период грудного вскармливания; детский возраст до 12 лет.

Способ применения и дозы

Внутрь, запивая водой.
Лечение пациентов с ожирением при ИМТ не менее 30 кг/м2 или пациентов с избыточной массой тела при ИМТ не менее 28 кг/ м2, в том числе имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно низкокалорийной диетой.
Взрослые и дети старше 12 лет
Рекомендованная доза препарата Листата - 1 таблетка (120 мг) с каждым основным приемом пищи (во время еды или не позднее чем через 1 час после еды).
В комбинации с гипогликемическими препаратами (метформин, производные сулъфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением.
Взрослые
Рекомендуемая доза препарата Листата 1 таблетка (120 мг) с каждым основным приемом пищи (во время еды или не позднее чем через 1 час после еды).
Если прием пищи пропускают или если пища не содержит жира, то прием препарата Листата также можно пропустить.
Препарат Листата следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять между 3 основными приемами пищи.
Увеличение дозы препарата Листата свыше рекомендованной (120 мг 3 раза в день) не приводит к усилению его терапевтического эффекта.
Эффективность и безопасность препарата Листата у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого возраста и детей до 12 лет не исследовались.
Полная инструкция
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Листата таб. п/о плен.
Листата таб. п/о плен., 120 мг, 80 шт.
4.7
(52)
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6 вопросов
Инструкция

2 909 ₽

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4.7
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У продавца:52 оценки·9 отзывов
У всех продавцов:353 оценки·76 отзывов
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user avatar
3 месяца назад • Имя скрыто • Куплен на Маркете
Достоинства: Таблетки прописаны врачом. Принимаю второй год. Всё особенности приёма подробно описаны в аннотации лекарства, к ним можно приспособиться. Читала комментарии - если кто-то думает, что съел таблетку и похудел, разочарую. Это лекарство, а не волшебство. Таблетки помогают и действуют в комплексе с другими усилиями. Врач прописала Листату-мини, но мне Листа больше подошла.
user avatar
2 месяца назад • Fire Dragon • Куплен на Маркете
Достоинства: Работают
Недостатки: Нет
Комментарий: Принимать нужно только совместно с рекомендациями диетолога, тогда работают
user avatar
4 месяца назад • Анна Галимова • Куплен на Маркете
Достоинства: Мягкое действие, если умеренно питаться.
Недостатки: Пока не нашла, только начала пить.
Комментарий: Подробнее могу сказать через 1-2 месяца.
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  • Орлистат-Акрихин капс., 60 мг, 42 шт.
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    Орлистат-Акрихин капс., 60 мг, 42 шт.

    Цена 817 ₽ вместо 825
  • Vitamin D3, 10000 МЕ, 120 шт.
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    Vitamin D3, 10000 МЕ, 120 шт.

    Цена 1 190 ₽ вместо 2 455
  • ЛимфоТранзит концентрат напитка фл., 100 мл
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_4/content/content/gallery":{"title":"ЛимфоТранзит концентрат напитка фл., 100 мл","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6fLm5feP9fcHEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMD4ltEGEI2Jl7wCGNW7oQYg19zBBw==","sign":"IPaNk8CjSY+1o31jL8WFnlzmfIpNh34xPF0rr2Lx0xM="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_4/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • Орлистат-акрихин капс., 120 мг, 84 шт.
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    Орлистат-акрихин капс., 120 мг, 84 шт.

    Цена 3 185 ₽
  • Жидкий пластырь Fixplast c пантенолом, 60 мл
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    Жидкий пластырь Fixplast c пантенолом, 60 мл

    Цена 333 ₽ вместо 399
  • Редуксин капс., 10 мг+158.5 мг, 30 шт.
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    Редуксин капс., 10 мг+158.5 мг, 30 шт.

    Цена 2 749 ₽
  • Реклама
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  • Орсотен Слим капс., 60 мг, 42 шт.
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    Орсотен Слим капс., 60 мг, 42 шт.

    Цена 1 220 ₽ вместо 1 232
  • Флексотрон Соло импл. вязкоэластич. стер. для в/суст. ин., 22 мг/мл, 2 мл, 1 шт.
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    Флексотрон Соло импл. вязкоэластич. стер. для в/суст. ин., 22 мг/мл, 2 мл, 1 шт.

    Цена 15 939 ₽ вместо 16 100
  • Вата стерильная хирургическая 100 г
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    Вата стерильная хирургическая 100 г

    Цена 173 ₽ вместо 198
  • Орсотен капс., 120 мг, 21 шт.
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    Орсотен капс., 120 мг, 21 шт.

    Цена 1 035 ₽
  • Орлистат-акрихин капс., 120 мг, 42 шт.
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    Орлистат-акрихин капс., 120 мг, 42 шт.

    Цена 1 689 ₽
  • Редуксин Форте таб. п/о плен., 850 мг+10 мг, 30 шт.
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    Редуксин Форте таб. п/о плен., 850 мг+10 мг, 30 шт.

    Цена 2 679 ₽
  • Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.
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    Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.

    Цена 282 ₽ вместо 520
  • Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.
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    Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.

    Цена 421 ₽ вместо 425
  • Ксеникал капс., 120 мг, 21 шт.
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    Ксеникал капс., 120 мг, 21 шт.

    Цена 1 012 ₽
  • Nutridrink (Nutricia) Compact Protein, готовое к употреблению, 500 мл, 500 г, банан, 4 шт.
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    Nutridrink (Nutricia) Compact Protein, готовое к употреблению, 500 мл, 500 г, банан, 4 шт.

    Цена 1 320 ₽ вместо 1 333
  • Ксеникал капс., 120 мг, 84 шт.
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    Ксеникал капс., 120 мг, 84 шт.

    Цена 3 570 ₽
  • Nutrison (Nutricia) Эдванс, сухая смесь, 332 мл, 322 г, нейтральный
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:253165360_20/content/content/toggleWishlist":{"skuId":"100498297658","productId":253165360,"offerId":"BF6ye9_qTCUDA2fU8iH5RQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6fLm5feP9fcHEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCLD+23gQuqapsfYCGOmR2gcgmI/VBw==","sign":"oDjxlCPTTlx2V8xmLHvbZr3ZOTfujaKnHr+qnw+2THE="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:253165360_20/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Nutrison (Nutricia) Эдванс, сухая смесь, 332 мл, 322 г, нейтральный

    Цена 1 114 ₽ вместо 1 125
  • Реклама
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  • Хило-комод р-р увлажняющий офтальмологический конт., 1 мг/мл, 10 мл, 1 шт.
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    Хило-комод р-р увлажняющий офтальмологический конт., 1 мг/мл, 10 мл, 1 шт.

    Цена 754 ₽ вместо 762
  • Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов
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    Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов

    Цена 194 ₽ вместо 224
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