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Описание

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Манинил таб., 1.75 мг, 120 шт.

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Коротко о товаре

Артикул Маркета
3129157933
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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система"},{"name":"Назначение","value":"сахарный диабет 2 типа","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["36476390:36618138"]}}},{"name":"Показания к применению","value":"Сахарный диабет 2 типа в качестве монотерапии или в составе комбинированной терапии с другими пероральными гипогликемическими препаратами, кроме производных сульфонилмочевины и глинидов."},{"name":"Противопоказания","value":"— повышенная чувствительность к глибенкламиду и/или компонентам, входящим в состав препарата;\u003Cbr\u003E— повышенная чувствительность к другим производным сульфонилмочевины, сульфаниламидам, мочегонным (диуретическим) средствам, содержащим в молекуле сульфонамидную группу, и к пробенециду, т. к. могут возникать перекрестные реакции;\u003Cbr\u003E— сахарный диабет типа 1;\u003Cbr\u003E— диабетический кетоацидоз, диабетическая прекома и кома;\u003Cbr\u003E— состояние после резекции поджелудочной железы;\u003Cbr\u003E— тяжелая печеночная недостаточность;\u003Cbr\u003E— почечная недостаточность тяжелой степени (КК менее 30 мл/мин);\u003Cbr\u003E— декомпенсация углеводного обмена при инфекционных заболеваниях, ожогах, травмах или после больших хирургических операций, когда показано проведение инсулинотерапии;\u003Cbr\u003E— лейкопения;\u003Cbr\u003E— кишечная непроходимость, парез желудка;\u003Cbr\u003E— наследственная непереносимость лактозы, дефицит лактазы или синдром мальабсорбции глюкозы и лактозы;\u003Cbr\u003E— дефицит глюкозо-6-фосфатдегидрогеназы;\u003Cbr\u003E— беременность;\u003Cbr\u003E— период лактации (грудного вскармливания);\u003Cbr\u003E— детский и подростковый возраст до 18 лет (эффективности и безопасность не изучены).\u003Cbr\u003EС осторожностью следует назначать препарат при заболеваниях щитовидной железы (с нарушением функции), лихорадочном синдроме, гипофункции передней доли гипофиза или коры надпочечников, хроническом алкоголизме, острой алкогольной интоксикации, у пациентов пожилого возраста (старше 70 лет) из-за опасности развития гипогликемии."},{"name":"Состав","value":"Действующее вещество: глибенкламид (микронизированный) – 1.75 мг\u003Cbr\u003EВспомогательные вещества: лактозы моногидрат – 68.99967 мг, крахмал картофельный – 26 мг, гимэтеллоза – 11 мг, кремния диоксид коллоидный – 2 мг, магния стеарат – 0.25 мг, краситель пунцовый (Понсо 4R) (Е124) – 0.00033 мг."},{"name":"Действующее вещество","value":"Глибенкламид","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["27144131:28708851"]}}},{"name":"Способ применения и дозы","value":"Доза препарата зависит от возраста, тяжести течения диабета, концентрации глюкозы в крови натощак и через 2 ч после еды. \u003Cbr\u003EНачальная доза препарата Манинил 1,75 составляет 1-2 таблетки (1,75 мг - 3,5 мг) 1 раз в сутки. Если начальная доза не приводит к достижению адекватного метаболического контроля, дозу препарата Манинил 1,75 следует поэтапно, под врачебным контролем повысить. Повышение дозы следует производить с интервалами от нескольких дней до одной недели, вплоть до достижения требуемой терапевтической дозы, которая не должна превышать максимальную. \u003Cbr\u003EМаксимальная суточная доза препарата Манинил 1,75-6 таблеток (10,5 мг) в сутки. Если доза препарата превышает 3 таблетки препарата Манинил 1,75 в сутки, рекомендуется использовать препарат Манинил 3,5. \u003Cbr\u003EПрепарат следует принимать перед едой, не разжевывая и запивая небольшим количеством жидкости. Суточные дозы препарата, составляющие до 2 таблеток следует принимать 1 раз в сутки - утром, непосредственно перед завтраком. Более высокие дозы делят на утренний и вечерний прием в соотношении 2:1. \u003Cbr\u003EПри пропуске одного приема препарата, следующую дозу препарата следует принять в обычное время, при этом не разрешается принимать более высокую дозу. \u003Cbr\u003EПожилым, ослабленнъш пациентам или пациентам с пониженным питанием, а также страдающим тяжелыми нарушениями функции почек или печени начальную и поддерживающую дозу необходимо снизить из-за опасности развития гипогликемии. \u003Cbr\u003EПеревод с других гипогликемических средств: \u003Cbr\u003EПереход с других гипогликемических препаратов на препарат Манинил 1,75 следует начинать под наблюдением врача с 1-2 таблеток препарата Манинил 1,75 в сутки (1,75 мг - 3,5 мг), постепенно повышая дозу до необходимой терапевтической."},{"name":"Побочные действия","value":"Определение частоты побочных эффектов: часто (\u003E1/100, \u003C1/10), нечасто (\u003E1/1000, \u003C1/100), редко (\u003E1/10 000, \u003C1/1000), очень редко (\u003C 1/10 000), включая отдельные сообщения.\u003Cbr\u003EСо стороны обмена веществ: часто - гипогликемия (чувство голода, гипертермия, тахикардия, сонливость, слабость, влажность кожных покровов, нарушение координации движений, тремор, общее беспокойство, чувство страха, головная боль, преходящие неврологические нарушения, в т.ч. расстройства зрения и речи, появление парезов или параличей или измененные восприятия ощущений); увеличение массы тела;\u003Cbr\u003EСо стороны пищеварительной системы: нечасто - тошнота, чувство тяжести в желудке, отрыжка, рвота, абдоминальные боли, диарея, металлический привкус во рту.\u003Cbr\u003EСо стороны печени и желчевыводящих путей: очень редко - временное повышение активности печеночных ферментов, внутрипеченочный холестаз, гепатит.\u003Cbr\u003EСо стороны иммунной системы: нечасто - зуд, крапивница, пурпура, петехии, повышенная фотосенсибилизация; очень редко - генерализованные аллергические реакции, сопровождающиеся кожной сыпью, артралгией, лихорадкой, протеинурией и желтухой; аллергический васкулит; анафилактический шок.\u003Cbr\u003EСо стороны системы кроветворения: редко - тромбоцитопения; очень редко: лейкопения, эритропения, агранулоцитоз; в единичных случаях - панцитопения, гемолитическая анемия.\u003Cbr\u003EПрочие: очень редко - нарушение зрения и расстройства аккомодации, усиление диуреза, преходящая протеинурия, гипонатриемия, дисульфирамоподобная реакция при приеме алкоголя (наиболее частые признаки эффекта: тошнота, рвота, боли в животе, ощущение жара кожи лица и верхней части туловища, тахикардия, головокружение, головная боль), перекрестная аллергия на пробенецид, производные сульфонилмочевины, сульфаниламиды, мочегонные (диуретические) средства, содержащие в молекуле сульфонамидную группу."},{"name":"Фармакологическое действие","value":"Глибенкламид стимулирует секрецию инсулина путем снижения порога раздражения глюкозой бета-клеток поджелудочной железы, повышает чувствительность к инсулину и степень его связывания с клетками-мишенями, увеличивает высвобождение инсулина, усиливает действие инсулина на поглощение глюкозы мышцами и печенью, тормозит липолиз в жировой ткани. Действует во второй стадии секреции инсулина. Оказывает гиполипидемическое действие, снижает тромбогенные свойства крови.\u003Cbr\u003EМанинил1,75 в микронизированной форме представляет собой высокотехнологичную, особым образом измельченную форму глибенкламида, позволяющую препарату быстрее абсорбироваться из желудочно-кишечного тракта. В связи с более ранним достижением максимальной концентрации глибенкламида в плазме крови, гипогликемический эффект практически соответствует по времени подъему концентрации глюкозы в плазме крови после еды, что делает действие препарата более мягким и физиологичным. Длительность гипогликемического действия глибенкламида зависти от дозы и может длиться до 24 ч."},{"name":"Фармакологическая группа","value":"гипогликемическое средство для перорального применения группы сульфонилмочевины II поколения"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 30°С."},{"name":"Передозировка","value":"Симптомы: гипогликемия (чувство голода, гипертермия, тахикардия, сонливость, слабость, влажность кожных покровов, нарушение координации движений, тремор, общее беспокойство, чувство страха, головная боль, преходящие неврологические нарушения (например, расстройства зрения и речи, проявления парезов или параличей или измененные восприятия ощущений). При прогрессировании гипогликемии возможна потеря больным самоконтроля и сознания, развитие гипогликемической комы.\u003Cbr\u003EЛечение: при гипогликемии легкой степени пациенту следует принять внутрь кусочек сахара, пищу или напитки с высоким содержанием сахара (варенье, мед, стакан сладкого чая). При потере сознания необходимо ввести в/в глюкозу - 40-80 мл 40% раствора декстрозы (глюкозы), затем инфузия 5-10% раствора декстрозы. Затем можно дополнительно ввести 1 мг глюкагона в/в, в/м или п/к. Если пациент не приходит в сознание, то эту меру можно повторить; далее может потребоваться проведение интенсивной терапии."},{"name":"Применение при беременности и кормлении грудью","value":"Применение препарата Манинил 1,75 при беременности и в период грудного вскармливания противопоказано. При наступлении беременности прием препарата, необходимо прекратить."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Во время лечения необходимо соблюдать осторожность при управлении транспортными средствами и другими потенциально опасными видами деятельности, требующих концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Во время лечения препаратом Манинил необходимо неукоснительно соблюдать рекомендации врача по соблюдению диеты и самоконтролю концентрации глюкозы в крови.\u003Cbr\u003EДлительное воздержание от приема пищи, недостаточное обеспечение организма углеводами, интенсивная физическая нагрузка, диарея или рвота представляют собой риск развития гипогликемии.\u003Cbr\u003EОдновременный прием лекарств, обладающих действием на ЦНС, снижающих АД (в т.ч. бета-адреноблокаторов), а также периферическая невропатия могут маскировать симптомы гипогликемии.\u003Cbr\u003EУ пациентов пожилого возраста риск развития гипогликемии несколько выше, поэтому необходим более тщательный подбор дозы препарата и регулярный контроль концентрации глюкозы в крови натощак и после приема пищи, особенно в начале лечения.\u003Cbr\u003EАлкоголь может провоцировать развитие гипогликемии, а также развитие дисульфирамоподобной реакции (тошнота, рвота, боль в животе, ощущение жара кожи лица и верхней части туловища, тахикардия, головокружение, головная боль), поэтому следует воздерживаться от приема алкоголя во время лечения препаратом Манинил®.\u003Cbr\u003EБольшие хирургические вмешательства и травмы, обширные ожоги, инфекционные заболевания с лихорадочным синдромом могут потребовать отмены пероральных гипогликемических лекарственных средств и назначения инсулина.\u003Cbr\u003EВо время лечения не рекомендуется длительное пребывание на солнце."},{"name":"Взаимодействие","value":"Усиление гипогликемического действия препарата Манинил возможно при одновременном приеме с ингибиторами АПФ, анаболическими средствами и мужскими половыми гормонами, другими пероральными гипогликемическими средствами (например, акарбозой, бигуанидами) и инсулином, азапропазоном, НПВС, бета-адреноблокаторами, производными хинолона, хлорамфениколом, клофибратом и его аналогами, производными кумарина, дизопирамидом, фенфлурамином, противогрибковыми лекарственными средствами (миконазол, флуконазол), флуоксетином, ингибиторами МАО, ПАСК, пентоксифиллином (в высоких доза при парентеральном введении), пергексилином, производными пиразолонов, фосфамидами (например, циклофосфамидом, ифосфамидом, трофосфамидом), пробенецидом, салицилатами, сульфонамидами, тетрациклинами и тритоквалином.\u003Cbr\u003EПодкисляющие мочу средства (аммония хлорид, кальция хлорид) усиливают действие препарата Манинил за счет уменьшения степени его диссоциации и повышения его реабсорбции.\u003Cbr\u003EГипогликемическое действие препарата Манинил может уменьшаться при одновременном применении барбитуратов, изониазида, диазоксида, ГКС, глюкагона, никотинатов (в высоких дозах), фенитоина, фенотиазинов, рифампицина, тиазидных диуретиков, ацетазоламида, пероральными контрацептивами и эстрогенами, препаратами гормонов щитовидной железы, симпатомиметических средств, блокаторами медленных кальциевых каналов, солей лития.\u003Cbr\u003EАнтагонисты Н2-рецепторов могут с одной стороны ослаблять, а с другой усиливать гипогликемическое действие препарата Манинил.\u003Cbr\u003EПентамидин в единичных случаях может вызывать сильное снижение или повышение концентрации глюкозы в крови.\u003Cbr\u003EПри одновременном применении с препаратом Манинил может усиливаться или ослабевать действие производных кумарина.\u003Cbr\u003EНаряду с усилением гипогликемического действия бета-адреноблокаторы, клонидин, гуанетидин и резерпин, а также лекарственные средства с центральным механизмом действия, могут ослаблять ощущение предвестников симптомов гипогликемии."},{"name":"Регистрационный номер","value":"П N012252/01"},{"name":"Дата государственной регистрации","value":"06.06.2019"},{"name":"Владелец регистрационного удостоверения","value":"Berlin-Chemie","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["34324371:35649313","7893318:16002727"]}}},{"name":"Изготовитель","value":"Berlin-Chemie"},{"name":"Фасовщик","value":"Menarini"},{"name":"Страна-производитель","value":"Германия"},{"name":"Название препарата","value":"Манинил","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-sakharnogo-diabeta","categoryId":"15756510","navnodeId":"72472","glfilters":["17796364:18045542"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"6625551510565794828":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"эндокринная система"},{"name":"Назначение","value":"сахарный диабет 2 типа"},{"name":"Показания к применению","value":"Сахарный диабет 2 типа в качестве монотерапии или в составе комбинированной терапии с другими пероральными гипогликемическими препаратами, кроме производных сульфонилмочевины и глинидов."},{"name":"Противопоказания","value":"— повышенная чувствительность к глибенкламиду и/или компонентам, входящим в состав препарата;\u003Cbr\u003E— повышенная чувствительность к другим производным сульфонилмочевины, сульфаниламидам, мочегонным (диуретическим) средствам, содержащим в молекуле сульфонамидную группу, и к пробенециду, т. к. могут возникать перекрестные реакции;\u003Cbr\u003E— сахарный диабет типа 1;\u003Cbr\u003E— диабетический кетоацидоз, диабетическая прекома и кома;\u003Cbr\u003E— состояние после резекции поджелудочной железы;\u003Cbr\u003E— тяжелая печеночная недостаточность;\u003Cbr\u003E— почечная недостаточность тяжелой степени (КК менее 30 мл/мин);\u003Cbr\u003E— декомпенсация углеводного обмена при инфекционных заболеваниях, ожогах, травмах или после больших хирургических операций, когда показано проведение инсулинотерапии;\u003Cbr\u003E— лейкопения;\u003Cbr\u003E— кишечная непроходимость, парез желудка;\u003Cbr\u003E— наследственная непереносимость лактозы, дефицит лактазы или синдром мальабсорбции глюкозы и лактозы;\u003Cbr\u003E— дефицит глюкозо-6-фосфатдегидрогеназы;\u003Cbr\u003E— беременность;\u003Cbr\u003E— период лактации (грудного вскармливания);\u003Cbr\u003E— детский и подростковый возраст до 18 лет (эффективности и безопасность не изучены).\u003Cbr\u003EС осторожностью следует назначать препарат при заболеваниях щитовидной железы (с нарушением функции), лихорадочном синдроме, гипофункции передней доли гипофиза или коры надпочечников, хроническом алкоголизме, острой алкогольной интоксикации, у пациентов пожилого возраста (старше 70 лет) из-за опасности развития гипогликемии."},{"name":"Состав","value":"Действующее вещество: глибенкламид (микронизированный) – 1.75 мг\u003Cbr\u003EВспомогательные вещества: лактозы моногидрат – 68.99967 мг, крахмал картофельный – 26 мг, гимэтеллоза – 11 мг, кремния диоксид коллоидный – 2 мг, магния стеарат – 0.25 мг, краситель пунцовый (Понсо 4R) (Е124) – 0.00033 мг."},{"name":"Действующее вещество","value":"Глибенкламид"},{"name":"Способ применения и дозы","value":"Доза препарата зависит от возраста, тяжести течения диабета, концентрации глюкозы в крови натощак и через 2 ч после еды. \u003Cbr\u003EНачальная доза препарата Манинил 1,75 составляет 1-2 таблетки (1,75 мг - 3,5 мг) 1 раз в сутки. Если начальная доза не приводит к достижению адекватного метаболического контроля, дозу препарата Манинил 1,75 следует поэтапно, под врачебным контролем повысить. Повышение дозы следует производить с интервалами от нескольких дней до одной недели, вплоть до достижения требуемой терапевтической дозы, которая не должна превышать максимальную. \u003Cbr\u003EМаксимальная суточная доза препарата Манинил 1,75-6 таблеток (10,5 мг) в сутки. Если доза препарата превышает 3 таблетки препарата Манинил 1,75 в сутки, рекомендуется использовать препарат Манинил 3,5. \u003Cbr\u003EПрепарат следует принимать перед едой, не разжевывая и запивая небольшим количеством жидкости. Суточные дозы препарата, составляющие до 2 таблеток следует принимать 1 раз в сутки - утром, непосредственно перед завтраком. Более высокие дозы делят на утренний и вечерний прием в соотношении 2:1. \u003Cbr\u003EПри пропуске одного приема препарата, следующую дозу препарата следует принять в обычное время, при этом не разрешается принимать более высокую дозу. \u003Cbr\u003EПожилым, ослабленнъш пациентам или пациентам с пониженным питанием, а также страдающим тяжелыми нарушениями функции почек или печени начальную и поддерживающую дозу необходимо снизить из-за опасности развития гипогликемии. \u003Cbr\u003EПеревод с других гипогликемических средств: \u003Cbr\u003EПереход с других гипогликемических препаратов на препарат Манинил 1,75 следует начинать под наблюдением врача с 1-2 таблеток препарата Манинил 1,75 в сутки (1,75 мг - 3,5 мг), постепенно повышая дозу до необходимой терапевтической."},{"name":"Побочные действия","value":"Определение частоты побочных эффектов: часто (\u003E1/100, \u003C1/10), нечасто (\u003E1/1000, \u003C1/100), редко (\u003E1/10 000, \u003C1/1000), очень редко (\u003C 1/10 000), включая отдельные сообщения.\u003Cbr\u003EСо стороны обмена веществ: часто - гипогликемия (чувство голода, гипертермия, тахикардия, сонливость, слабость, влажность кожных покровов, нарушение координации движений, тремор, общее беспокойство, чувство страха, головная боль, преходящие неврологические нарушения, в т.ч. расстройства зрения и речи, появление парезов или параличей или измененные восприятия ощущений); увеличение массы тела;\u003Cbr\u003EСо стороны пищеварительной системы: нечасто - тошнота, чувство тяжести в желудке, отрыжка, рвота, абдоминальные боли, диарея, металлический привкус во рту.\u003Cbr\u003EСо стороны печени и желчевыводящих путей: очень редко - временное повышение активности печеночных ферментов, внутрипеченочный холестаз, гепатит.\u003Cbr\u003EСо стороны иммунной системы: нечасто - зуд, крапивница, пурпура, петехии, повышенная фотосенсибилизация; очень редко - генерализованные аллергические реакции, сопровождающиеся кожной сыпью, артралгией, лихорадкой, протеинурией и желтухой; аллергический васкулит; анафилактический шок.\u003Cbr\u003EСо стороны системы кроветворения: редко - тромбоцитопения; очень редко: лейкопения, эритропения, агранулоцитоз; в единичных случаях - панцитопения, гемолитическая анемия.\u003Cbr\u003EПрочие: очень редко - нарушение зрения и расстройства аккомодации, усиление диуреза, преходящая протеинурия, гипонатриемия, дисульфирамоподобная реакция при приеме алкоголя (наиболее частые признаки эффекта: тошнота, рвота, боли в животе, ощущение жара кожи лица и верхней части туловища, тахикардия, головокружение, головная боль), перекрестная аллергия на пробенецид, производные сульфонилмочевины, сульфаниламиды, мочегонные (диуретические) средства, содержащие в молекуле сульфонамидную группу."},{"name":"Фармакологическое действие","value":"Глибенкламид стимулирует секрецию инсулина путем снижения порога раздражения глюкозой бета-клеток поджелудочной железы, повышает чувствительность к инсулину и степень его связывания с клетками-мишенями, увеличивает высвобождение инсулина, усиливает действие инсулина на поглощение глюкозы мышцами и печенью, тормозит липолиз в жировой ткани. Действует во второй стадии секреции инсулина. Оказывает гиполипидемическое действие, снижает тромбогенные свойства крови.\u003Cbr\u003EМанинил1,75 в микронизированной форме представляет собой высокотехнологичную, особым образом измельченную форму глибенкламида, позволяющую препарату быстрее абсорбироваться из желудочно-кишечного тракта. В связи с более ранним достижением максимальной концентрации глибенкламида в плазме крови, гипогликемический эффект практически соответствует по времени подъему концентрации глюкозы в плазме крови после еды, что делает действие препарата более мягким и физиологичным. Длительность гипогликемического действия глибенкламида зависти от дозы и может длиться до 24 ч."},{"name":"Фармакологическая группа","value":"гипогликемическое средство для перорального применения группы сульфонилмочевины II поколения"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 30°С."},{"name":"Передозировка","value":"Симптомы: гипогликемия (чувство голода, гипертермия, тахикардия, сонливость, слабость, влажность кожных покровов, нарушение координации движений, тремор, общее беспокойство, чувство страха, головная боль, преходящие неврологические нарушения (например, расстройства зрения и речи, проявления парезов или параличей или измененные восприятия ощущений). При прогрессировании гипогликемии возможна потеря больным самоконтроля и сознания, развитие гипогликемической комы.\u003Cbr\u003EЛечение: при гипогликемии легкой степени пациенту следует принять внутрь кусочек сахара, пищу или напитки с высоким содержанием сахара (варенье, мед, стакан сладкого чая). При потере сознания необходимо ввести в/в глюкозу - 40-80 мл 40% раствора декстрозы (глюкозы), затем инфузия 5-10% раствора декстрозы. Затем можно дополнительно ввести 1 мг глюкагона в/в, в/м или п/к. Если пациент не приходит в сознание, то эту меру можно повторить; далее может потребоваться проведение интенсивной терапии."},{"name":"Применение при беременности и кормлении грудью","value":"Применение препарата Манинил 1,75 при беременности и в период грудного вскармливания противопоказано. При наступлении беременности прием препарата, необходимо прекратить."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Во время лечения необходимо соблюдать осторожность при управлении транспортными средствами и другими потенциально опасными видами деятельности, требующих концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Во время лечения препаратом Манинил необходимо неукоснительно соблюдать рекомендации врача по соблюдению диеты и самоконтролю концентрации глюкозы в крови.\u003Cbr\u003EДлительное воздержание от приема пищи, недостаточное обеспечение организма углеводами, интенсивная физическая нагрузка, диарея или рвота представляют собой риск развития гипогликемии.\u003Cbr\u003EОдновременный прием лекарств, обладающих действием на ЦНС, снижающих АД (в т.ч. бета-адреноблокаторов), а также периферическая невропатия могут маскировать симптомы гипогликемии.\u003Cbr\u003EУ пациентов пожилого возраста риск развития гипогликемии несколько выше, поэтому необходим более тщательный подбор дозы препарата и регулярный контроль концентрации глюкозы в крови натощак и после приема пищи, особенно в начале лечения.\u003Cbr\u003EАлкоголь может провоцировать развитие гипогликемии, а также развитие дисульфирамоподобной реакции (тошнота, рвота, боль в животе, ощущение жара кожи лица и верхней части туловища, тахикардия, головокружение, головная боль), поэтому следует воздерживаться от приема алкоголя во время лечения препаратом Манинил®.\u003Cbr\u003EБольшие хирургические вмешательства и травмы, обширные ожоги, инфекционные заболевания с лихорадочным синдромом могут потребовать отмены пероральных гипогликемических лекарственных средств и назначения инсулина.\u003Cbr\u003EВо время лечения не рекомендуется длительное пребывание на солнце."},{"name":"Взаимодействие","value":"Усиление гипогликемического действия препарата Манинил возможно при одновременном приеме с ингибиторами АПФ, анаболическими средствами и мужскими половыми гормонами, другими пероральными гипогликемическими средствами (например, акарбозой, бигуанидами) и инсулином, азапропазоном, НПВС, бета-адреноблокаторами, производными хинолона, хлорамфениколом, клофибратом и его аналогами, производными кумарина, дизопирамидом, фенфлурамином, противогрибковыми лекарственными средствами (миконазол, флуконазол), флуоксетином, ингибиторами МАО, ПАСК, пентоксифиллином (в высоких доза при парентеральном введении), пергексилином, производными пиразолонов, фосфамидами (например, циклофосфамидом, ифосфамидом, трофосфамидом), пробенецидом, салицилатами, сульфонамидами, тетрациклинами и тритоквалином.\u003Cbr\u003EПодкисляющие мочу средства (аммония хлорид, кальция хлорид) усиливают действие препарата Манинил за счет уменьшения степени его диссоциации и повышения его реабсорбции.\u003Cbr\u003EГипогликемическое действие препарата Манинил может уменьшаться при одновременном применении барбитуратов, изониазида, диазоксида, ГКС, глюкагона, никотинатов (в высоких дозах), фенитоина, фенотиазинов, рифампицина, тиазидных диуретиков, ацетазоламида, пероральными контрацептивами и эстрогенами, препаратами гормонов щитовидной железы, симпатомиметических средств, блокаторами медленных кальциевых каналов, солей лития.\u003Cbr\u003EАнтагонисты Н2-рецепторов могут с одной стороны ослаблять, а с другой усиливать гипогликемическое действие препарата Манинил.\u003Cbr\u003EПентамидин в единичных случаях может вызывать сильное снижение или повышение концентрации глюкозы в крови.\u003Cbr\u003EПри одновременном применении с препаратом Манинил может усиливаться или ослабевать действие производных кумарина.\u003Cbr\u003EНаряду с усилением гипогликемического действия бета-адреноблокаторы, клонидин, гуанетидин и резерпин, а также лекарственные средства с центральным механизмом действия, могут ослаблять ощущение предвестников симптомов гипогликемии."},{"name":"Регистрационный номер","value":"П N012252/01"},{"name":"Дата государственной регистрации","value":"06.06.2019"},{"name":"Владелец регистрационного удостоверения","value":"Berlin-Chemie"},{"name":"Изготовитель","value":"Berlin-Chemie"},{"name":"Фасовщик","value":"Menarini"},{"name":"Страна-производитель","value":"Германия"},{"name":"Название препарата","value":"Манинил"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_6"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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Если начальная доза не приводит к достижению адекватного метаболического контроля, дозу препарата Манинил 1,75 следует поэтапно, под врачебным контролем повысить. Повышение дозы следует производить с интервалами от нескольких дней до одной недели, вплоть до достижения требуемой терапевтической дозы, которая не должна превышать максимальную. \u003Cbr\u003EМаксимальная суточная доза препарата Манинил 1,75-6 таблеток (10,5 мг) в сутки. Если доза препарата превышает 3 таблетки препарата Манинил 1,75 в сутки, рекомендуется использовать препарат Манинил 3,5. \u003Cbr\u003EПрепарат следует принимать перед едой, не разжевывая и запивая небольшим количеством жидкости. Суточные дозы препарата, составляющие до 2 таблеток следует принимать 1 раз в сутки - утром, непосредственно перед завтраком. Более высокие дозы делят на утренний и вечерний прием в соотношении 2:1. \u003Cbr\u003EПри пропуске одного приема препарата, следующую дозу препарата следует принять в обычное время, при этом не разрешается принимать более высокую дозу. \u003Cbr\u003EПожилым, ослабленнъш пациентам или пациентам с пониженным питанием, а также страдающим тяжелыми нарушениями функции почек или печени начальную и поддерживающую дозу необходимо снизить из-за опасности развития гипогликемии. \u003Cbr\u003EПеревод с других гипогликемических средств: \u003Cbr\u003EПереход с других гипогликемических препаратов на препарат Манинил 1,75 следует начинать под наблюдением врача с 1-2 таблеток препарата Манинил 1,75 в сутки (1,75 мг - 3,5 мг), постепенно повышая дозу до необходимой терапевтической."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Определение частоты побочных эффектов: часто (\u003E1/100, \u003C1/10), нечасто (\u003E1/1000, \u003C1/100), редко (\u003E1/10 000, \u003C1/1000), очень редко (\u003C 1/10 000), включая отдельные сообщения.\u003Cbr\u003EСо стороны обмена веществ: часто - гипогликемия (чувство голода, гипертермия, тахикардия, сонливость, слабость, влажность кожных покровов, нарушение координации движений, тремор, общее беспокойство, чувство страха, головная боль, преходящие неврологические нарушения, в т.ч. расстройства зрения и речи, появление парезов или параличей или измененные восприятия ощущений); увеличение массы тела;\u003Cbr\u003EСо стороны пищеварительной системы: нечасто - тошнота, чувство тяжести в желудке, отрыжка, рвота, абдоминальные боли, диарея, металлический привкус во рту.\u003Cbr\u003EСо стороны печени и желчевыводящих путей: очень редко - временное повышение активности печеночных ферментов, внутрипеченочный холестаз, гепатит.\u003Cbr\u003EСо стороны иммунной системы: нечасто - зуд, крапивница, пурпура, петехии, повышенная фотосенсибилизация; очень редко - генерализованные аллергические реакции, сопровождающиеся кожной сыпью, артралгией, лихорадкой, протеинурией и желтухой; аллергический васкулит; анафилактический шок.\u003Cbr\u003EСо стороны системы кроветворения: редко - тромбоцитопения; очень редко: лейкопения, эритропения, агранулоцитоз; в единичных случаях - панцитопения, гемолитическая анемия.\u003Cbr\u003EПрочие: очень редко - нарушение зрения и расстройства аккомодации, усиление диуреза, преходящая протеинурия, гипонатриемия, дисульфирамоподобная реакция при приеме алкоголя (наиболее частые признаки эффекта: тошнота, рвота, боли в животе, ощущение жара кожи лица и верхней части туловища, тахикардия, головокружение, головная боль), перекрестная аллергия на пробенецид, производные сульфонилмочевины, сульфаниламиды, мочегонные (диуретические) средства, содержащие в молекуле сульфонамидную группу."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Глибенкламид стимулирует секрецию инсулина путем снижения порога раздражения глюкозой бета-клеток поджелудочной железы, повышает чувствительность к инсулину и степень его связывания с клетками-мишенями, увеличивает высвобождение инсулина, усиливает действие инсулина на поглощение глюкозы мышцами и печенью, тормозит липолиз в жировой ткани. Действует во второй стадии секреции инсулина. Оказывает гиполипидемическое действие, снижает тромбогенные свойства крови.\u003Cbr\u003EМанинил1,75 в микронизированной форме представляет собой высокотехнологичную, особым образом измельченную форму глибенкламида, позволяющую препарату быстрее абсорбироваться из желудочно-кишечного тракта. В связи с более ранним достижением максимальной концентрации глибенкламида в плазме крови, гипогликемический эффект практически соответствует по времени подъему концентрации глюкозы в плазме крови после еды, что делает действие препарата более мягким и физиологичным. Длительность гипогликемического действия глибенкламида зависти от дозы и может длиться до 24 ч."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"гипогликемическое средство для перорального применения группы сульфонилмочевины II поколения"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Препарат следует хранить в недоступном для детей месте при температуре не выше 30°С."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Симптомы: гипогликемия (чувство голода, гипертермия, тахикардия, сонливость, слабость, влажность кожных покровов, нарушение координации движений, тремор, общее беспокойство, чувство страха, головная боль, преходящие неврологические нарушения (например, расстройства зрения и речи, проявления парезов или параличей или измененные восприятия ощущений). При прогрессировании гипогликемии возможна потеря больным самоконтроля и сознания, развитие гипогликемической комы.\u003Cbr\u003EЛечение: при гипогликемии легкой степени пациенту следует принять внутрь кусочек сахара, пищу или напитки с высоким содержанием сахара (варенье, мед, стакан сладкого чая). При потере сознания необходимо ввести в/в глюкозу - 40-80 мл 40% раствора декстрозы (глюкозы), затем инфузия 5-10% раствора декстрозы. Затем можно дополнительно ввести 1 мг глюкагона в/в, в/м или п/к. Если пациент не приходит в сознание, то эту меру можно повторить; далее может потребоваться проведение интенсивной терапии."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Применение препарата Манинил 1,75 при беременности и в период грудного вскармливания противопоказано. При наступлении беременности прием препарата, необходимо прекратить."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Во время лечения необходимо соблюдать осторожность при управлении транспортными средствами и другими потенциально опасными видами деятельности, требующих концентрации внимания и быстроты психомоторных реакций."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Во время лечения препаратом Манинил необходимо неукоснительно соблюдать рекомендации врача по соблюдению диеты и самоконтролю концентрации глюкозы в крови.\u003Cbr\u003EДлительное воздержание от приема пищи, недостаточное обеспечение организма углеводами, интенсивная физическая нагрузка, диарея или рвота представляют собой риск развития гипогликемии.\u003Cbr\u003EОдновременный прием лекарств, обладающих действием на ЦНС, снижающих АД (в т.ч. бета-адреноблокаторов), а также периферическая невропатия могут маскировать симптомы гипогликемии.\u003Cbr\u003EУ пациентов пожилого возраста риск развития гипогликемии несколько выше, поэтому необходим более тщательный подбор дозы препарата и регулярный контроль концентрации глюкозы в крови натощак и после приема пищи, особенно в начале лечения.\u003Cbr\u003EАлкоголь может провоцировать развитие гипогликемии, а также развитие дисульфирамоподобной реакции (тошнота, рвота, боль в животе, ощущение жара кожи лица и верхней части туловища, тахикардия, головокружение, головная боль), поэтому следует воздерживаться от приема алкоголя во время лечения препаратом Манинил®.\u003Cbr\u003EБольшие хирургические вмешательства и травмы, обширные ожоги, инфекционные заболевания с лихорадочным синдромом могут потребовать отмены пероральных гипогликемических лекарственных средств и назначения инсулина.\u003Cbr\u003EВо время лечения не рекомендуется длительное пребывание на солнце."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Усиление гипогликемического действия препарата Манинил возможно при одновременном приеме с ингибиторами АПФ, анаболическими средствами и мужскими половыми гормонами, другими пероральными гипогликемическими средствами (например, акарбозой, бигуанидами) и инсулином, азапропазоном, НПВС, бета-адреноблокаторами, производными хинолона, хлорамфениколом, клофибратом и его аналогами, производными кумарина, дизопирамидом, фенфлурамином, противогрибковыми лекарственными средствами (миконазол, флуконазол), флуоксетином, ингибиторами МАО, ПАСК, пентоксифиллином (в высоких доза при парентеральном введении), пергексилином, производными пиразолонов, фосфамидами (например, циклофосфамидом, ифосфамидом, трофосфамидом), пробенецидом, салицилатами, сульфонамидами, тетрациклинами и тритоквалином.\u003Cbr\u003EПодкисляющие мочу средства (аммония хлорид, кальция хлорид) усиливают действие препарата Манинил за счет уменьшения степени его диссоциации и повышения его реабсорбции.\u003Cbr\u003EГипогликемическое действие препарата Манинил может уменьшаться при одновременном применении барбитуратов, изониазида, диазоксида, ГКС, глюкагона, никотинатов (в высоких дозах), фенитоина, фенотиазинов, рифампицина, тиазидных диуретиков, ацетазоламида, пероральными контрацептивами и эстрогенами, препаратами гормонов щитовидной железы, симпатомиметических средств, блокаторами медленных кальциевых каналов, солей лития.\u003Cbr\u003EАнтагонисты Н2-рецепторов могут с одной стороны ослаблять, а с другой усиливать гипогликемическое действие препарата Манинил.\u003Cbr\u003EПентамидин в единичных случаях может вызывать сильное снижение или повышение концентрации глюкозы в крови.\u003Cbr\u003EПри одновременном применении с препаратом Манинил может усиливаться или ослабевать действие производных кумарина.\u003Cbr\u003EНаряду с усилением гипогликемического действия бета-адреноблокаторы, клонидин, гуанетидин и резерпин, а также лекарственные средства с центральным механизмом действия, могут ослаблять ощущение предвестников симптомов гипогликемии."},{"description":"","filters":[{"id":16435314,"name":"Регистрационный номер"}],"isMainProperty":false,"name":"Регистрационный номер","value":"П N012252/01"},{"description":"","filters":[{"id":16435315,"name":"Дата государственной регистрации"}],"isMainProperty":false,"name":"Дата государственной регистрации","value":"06.06.2019"},{"description":"","filters":[{"id":34324371,"name":"Тип препарата"},{"id":7893318,"name":"Производитель"}],"isMainProperty":false,"name":"Владелец регистрационного 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    Цена 165 ₽
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  • Сиофор таб. п/о плен., 1000 мг, 60 шт.
    –17 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cnio5ymdyvc/toggleWishlist":{"skuId":"101372395736","productId":656559067,"offerId":"CHfVUpaRDnonKOuJ9LezBA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgkQubm44aLkwmQSMQovQ29tcGV0aXRpdmVBbmFsb2dzX01hcmtldE1vZGVsQ2FyZF9Gcm9udFNuaXBwZXQyFwjbl4m5AhDYgZDS+QIYp93QByDe2cEH","sign":"s6qSU9UPgIurLCnDwxXRFTbS6XuuyFhjkg9QfqbjLF4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cnio5ymdyvc/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Сиофор таб. п/о плен., 1000 мг, 60 шт.

    Рейтинг товара: 4.8 из 5
    на основе 37 оценок
    Цена 209 ₽ вместо 251
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  • Глюконорм таб. п/о плен., 2.5 мг+400 мг, 40 шт.
    –17 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0yl1zwn4bx5d/toggleWishlist":{"skuId":"186887108","productId":1778172429,"offerId":"jxxJ-k606ejrnTKTf5yPNQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgkQubm44aLkwmQSMQovQ29tcGV0aXRpdmVBbmFsb2dzX01hcmtldE1vZGVsQ2FyZF9Gcm9udFNuaXBwZXQyFQiNhPPPBhDE145ZGMei1Qcg3tnBBw==","sign":"KChvf7UGslIPovniP+kxOaRYOEn/HEZ9HUynrgVpXrc="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0yl1zwn4bx5d/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Глюконорм таб. п/о плен., 2.5 мг+400 мг, 40 шт.

    Рейтинг товара: 5 из 5
    на основе 8 оценок
    Цена 249 ₽ вместо 299
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  • Галвус таб., 50 мг, 28 шт.
    –16 %
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    Галвус таб., 50 мг, 28 шт.

    Рейтинг товара: 4.9 из 5
    на основе 42 оценки
    Цена 829 ₽ вместо 987
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  • Диабетон МВ таб. модиф. высвоб., 60 мг, 30 шт.
    –18 %
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    Диабетон МВ таб. модиф. высвоб., 60 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 26 оценок
    Цена 233 ₽ вместо 283
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  • Кселевия таб. п/о плен., 100 мг, 28 шт.
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    Кселевия таб. п/о плен., 100 мг, 28 шт.

    Рейтинг товара: 5 из 5
    на основе 10 оценок
    Цена 1 313 ₽
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  • Глидиаб МВ таб. модиф. высвоб., 30 мг, 60 шт.
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    Глидиаб МВ таб. модиф. высвоб., 30 мг, 60 шт.

    Рейтинг товара: 4.9 из 5
    на основе 15 оценок
    Цена 154 ₽
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  • Форметин таб., 0.5 г, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-iyjkoirkdn/toggleWishlist":{"skuId":"186426328","productId":998360000,"offerId":"F02pNBfSvDwydk_p_wiYoQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgkQubm44aLkwmQSMQovQ29tcGV0aXRpdmVBbmFsb2dzX01hcmtldE1vZGVsQ2FyZF9Gcm9udFNuaXBwZXQyFQjAh4fcAxDYx/JYGI+83gcg3tnBBw==","sign":"Vc1Ly/GiVHgZkz1P1dJKvyeP/x36r8uxYNnfDhEr3ew="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-iyjkoirkdn/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Форметин таб., 0.5 г, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    Цена 117 ₽
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  • Асиглия таб. п/о плен., 100 мг, 28 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-uiaz4hu3p1/toggleWishlist":{"skuId":"101841527736","productId":1775075334,"offerId":"_kQstAbcT9haYxFqtAkIXQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgkQubm44aLkwmQSMQovQ29tcGV0aXRpdmVBbmFsb2dzX01hcmtldE1vZGVsQ2FyZF9Gcm9udFNuaXBwZXQyFwiGgLbOBhC4x+mx+wIYttWHBCDe2cEH","sign":"N1hM2CeJuB7twada4XxLibtLJrGlZ+EVBrp7/D2KBDc="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-uiaz4hu3p1/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Асиглия таб. п/о плен., 100 мг, 28 шт.

    Рейтинг товара: 4.9 из 5
    на основе 52 оценки
    Цена 577 ₽
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  • Глюренорм таб., 30 мг, 60 шт.
    –21 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-nevzv9lesc/toggleWishlist":{"skuId":"227814183","productId":1778172437,"offerId":"kBFzOCJfbgqDjoMCCilpvA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgkQubm44aLkwmQSMQovQ29tcGV0aXRpdmVBbmFsb2dzX01hcmtldE1vZGVsQ2FyZF9Gcm9udFNuaXBwZXQyFQiVhPPPBhCn1tBsGMa03gcg3tnBBw==","sign":"ZbIxa+Hd2sMgk2dmsl5QS3e0qQEKYCraeODtDIehhuA="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-nevzv9lesc/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Глюренорм таб., 30 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 606 ₽ вместо 768
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-nevzv9lesc/addToCartButton":{"offerId":"kBFzOCJfbgqDjoMCCilpvA","skuId":"227814183","pendingCartItem":{"productId":1778172437,"offerId":"kBFzOCJfbgqDjoMCCilpvA","showPlaceId":"OTNDnItfwRMjN9MRHuEMMp3DfjyuEo8q59CiWIE_wguJWkj3THNjePci3gmRKRUPoIII82xQQ1TkZKWXp2JqhovIJfZsdiO7HWsZU4_7Xy1vo2KqJT6u3YHRUI7lron0qOFYRf8W-sEUBPzI_8MgK10WaToLujy-vzWiUiG6bqX527B1oTV7J437zXKo7IU-Pj-3ctpCLzezzy8LWBwdtw,,","feeShow":"OTNDnItfwRMjN9MRHuEMMp3DfjyuEo8q59CiWIE_wguJWkj3THNjePci3gmRKRUPoIII82xQQ1TkZKWXp2JqhovIJfZsdiO7HWsZU4_7Xy1vo2KqJT6u3YHRUI7lron0qOFYRf8W-sEUBPzI_8MgK10WaToLujy-vzWiUiG6bqX527B1oTV7J437zXKo7IU-Pj-3ctpCLzezzy8LWBwdtw,,","skuId":"227814183","shopId":4035369,"price":{"applicablePriceDiscounts":[],"discount":{"oldMin":"768","percent":21},"value":"606","currency":"RUR"},"hid":"15756510","name":"Глюренорм таб., 30 мг, 60 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  • Субетта таб. д/рассас., 100 шт.
    –2 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-yybbtheqxa/toggleWishlist":{"skuId":"265183627","productId":1778172468,"offerId":"PCyGQM237GWf7axwFw5VWw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgkQubm44aLkwmQSMQovQ29tcGV0aXRpdmVBbmFsb2dzX01hcmtldE1vZGVsQ2FyZF9Gcm9udFNuaXBwZXQyFQi0hPPPBhCLw7l+GKrg0Acg3tnBBw==","sign":"u5KaN4GSgo6eAui4DsKXbiidnBVNEaLTELxOIou1Law="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-yybbtheqxa/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Субетта таб. д/рассас., 100 шт.

    Рейтинг товара: 5 из 5
    на основе 11 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 599 ₽ вместо 611
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Инструкция

Показания к применению

Сахарный диабет 2 типа в качестве монотерапии или в составе комбинированной терапии с другими пероральными гипогликемическими препаратами, кроме производных сульфонилмочевины и глинидов.

Противопоказания

— повышенная чувствительность к глибенкламиду и/или компонентам, входящим в состав препарата;
— повышенная чувствительность к другим производным сульфонилмочевины, сульфаниламидам, мочегонным (диуретическим) средствам, содержащим в молекуле сульфонамидную группу, и к пробенециду, т. к. могут возникать перекрестные реакции;
— сахарный диабет типа 1;
— диабетический кетоацидоз, диабетическая прекома и кома;
— состояние после резекции поджелудочной железы;
— тяжелая печеночная недостаточность;
— почечная недостаточность тяжелой степени (КК менее 30 мл/мин);
— декомпенсация углеводного обмена при инфекционных заболеваниях, ожогах, травмах или после больших хирургических операций, когда показано проведение инсулинотерапии;
— лейкопения;
— кишечная непроходимость, парез желудка;
— наследственная непереносимость лактозы, дефицит лактазы или синдром мальабсорбции глюкозы и лактозы;
— дефицит глюкозо-6-фосфатдегидрогеназы;
— беременность;
— период лактации (грудного вскармливания);
— детский и подростковый возраст до 18 лет (эффективности и безопасность не изучены).
С осторожностью следует назначать препарат при заболеваниях щитовидной железы (с нарушением функции), лихорадочном синдроме, гипофункции передней доли гипофиза или коры надпочечников, хроническом алкоголизме, острой алкогольной интоксикации, у пациентов пожилого возраста (старше 70 лет) из-за опасности развития гипогликемии.

Способ применения и дозы

Доза препарата зависит от возраста, тяжести течения диабета, концентрации глюкозы в крови натощак и через 2 ч после еды.
Начальная доза препарата Манинил 1,75 составляет 1-2 таблетки (1,75 мг - 3,5 мг) 1 раз в сутки. Если начальная доза не приводит к достижению адекватного метаболического контроля, дозу препарата Манинил 1,75 следует поэтапно, под врачебным контролем повысить. Повышение дозы следует производить с интервалами от нескольких дней до одной недели, вплоть до достижения требуемой терапевтической дозы, которая не должна превышать максимальную.
Максимальная суточная доза препарата Манинил 1,75-6 таблеток (10,5 мг) в сутки. Если доза препарата превышает 3 таблетки препарата Манинил 1,75 в сутки, рекомендуется использовать препарат Манинил 3,5.
Препарат следует принимать перед едой, не разжевывая и запивая небольшим количеством жидкости. Суточные дозы препарата, составляющие до 2 таблеток следует принимать 1 раз в сутки - утром, непосредственно перед завтраком. Более высокие дозы делят на утренний и вечерний прием в соотношении 2:1.
При пропуске одного приема препарата, следующую дозу препарата следует принять в обычное время, при этом не разрешается принимать более высокую дозу.
Пожилым, ослабленнъш пациентам или пациентам с пониженным питанием, а также страдающим тяжелыми нарушениями функции почек или печени начальную и поддерживающую дозу необходимо снизить из-за опасности развития гипогликемии.
Перевод с других гипогликемических средств:
Переход с других гипогликемических препаратов на препарат Манинил 1,75 следует начинать под наблюдением врача с 1-2 таблеток препарата Манинил 1,75 в сутки (1,75 мг - 3,5 мг), постепенно повышая дозу до необходимой терапевтической.
Полная инструкция
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Манинил таб.
Манинил таб., 1.75 мг, 120 шт.
5.0
(1)
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Инструкция

105 ₽

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user avatar
28 ноября 2023 • Людмила Михайлова
Достоинства: недорогиеНедостатки: нетКомментарий: принимаются комплексно перед едой
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Рекомендуем

  • Манинил таб., 3.5 мг, 120 шт.
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    Манинил таб., 3.5 мг, 120 шт.

    Цена 165 ₽
  • Таблетница из 14 секций на семь дней Утро-вечер
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    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 166 ₽ вместо 190
  • VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер
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    VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер

    Цена 245 ₽ вместо 1 400
  • Сиофор таб. п/о плен., 1000 мг, 60 шт.
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    Сиофор таб. п/о плен., 1000 мг, 60 шт.

    Цена 209 ₽ вместо 251
  • Глюконорм таб. п/о плен., 2.5 мг+400 мг, 40 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172429_4/content/content/gallery":{"title":"Глюконорм таб. п/о плен., 2.5 мг+400 мг, 40 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/1478677/img_id1207674867840240467.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1478677/img_id1207674867840240467.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1478677/img_id1207674867840240467.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1478677/img_id1207674867840240467.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1478677/img_id1207674867840240467.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1478677/img_id1207674867840240467.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5068955/img_id2446691610215028236.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5068955/img_id2446691610215028236.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5068955/img_id2446691610215028236.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5068955/img_id2446691610215028236.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5068955/img_id2446691610215028236.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5068955/img_id2446691610215028236.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgkQubm44aLkwmQSGgoYcmVtaXhfZGVza3RvcF9tb2RlbF9jYXJkMhUIjYTzzwYQxNeOWRjHotUHIN7ZwQc=","sign":"pRhZ1u+1yWtla4wwP0eFSPusfM2xuBI6xx3cegMmpDg="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172429_4/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Глюконорм таб. п/о плен., 2.5 мг+400 мг, 40 шт.

    Цена 249 ₽ вместо 299
  • Галвус таб., 50 мг, 28 шт.
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    Галвус таб., 50 мг, 28 шт.

    Цена 829 ₽ вместо 987
  • Диабетон МВ таб. модиф. высвоб., 60 мг, 30 шт.
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    Диабетон МВ таб. модиф. высвоб., 60 мг, 30 шт.

    Цена 233 ₽ вместо 283
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 1 прием Компактный, Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 1 прием Компактный, Daswerk

    Цена 135 ₽ вместо 428
  • Реклама
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  • Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

    Цена 245 ₽ вместо 599
  • Таблетница на день мини для капсул контейнер для таблеток розовый
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1915570066_10/content/content/toggleWishlist":{"skuId":"102281158229","productId":1915570066,"offerId":"A8h-Dw0vz0G3f2SQ0W_3Xw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgkQubm44aLkwmQSGgoYcmVtaXhfZGVza3RvcF9tb2RlbF9jYXJkMhYIko+1kQcQ1by6g/0CGJL29wcgzc49","sign":"VS59qUhTfGm4sim73neEzRWMZ3waSWeMN7mEKsp3sTY="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1915570066_10/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Таблетница на день мини для капсул контейнер для таблеток розовый

    Цена 282 ₽ вместо 750
  • Кселевия таб. п/о плен., 100 мг, 28 шт.
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    Кселевия таб. п/о плен., 100 мг, 28 шт.

    Цена 1 313 ₽
  • Глидиаб МВ таб. модиф. высвоб., 30 мг, 60 шт.
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    Глидиаб МВ таб. модиф. высвоб., 30 мг, 60 шт.

    Цена 154 ₽
  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 166 ₽ вместо 400
  • Таблетница цилиндрическая вертикальная на 7 дней. Предназначена для упорядоченного и компактного хранения лекарственных средств и витаминов.
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    Таблетница цилиндрическая вертикальная на 7 дней. Предназначена для упорядоченного и компактного хранения лекарственных средств и витаминов.

    Цена 374 ₽ вместо 490
  • Таблетница 4 секции квадратная 5,5*5,5*3 см, пластик, цвет красный
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    Таблетница 4 секции квадратная 5,5*5,5*3 см, пластик, цвет красный

    Цена 108 ₽ вместо 240
  • Форметин таб., 0.5 г, 60 шт.
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    Форметин таб., 0.5 г, 60 шт.

    Цена 117 ₽
  • Асиглия таб. п/о плен., 100 мг, 28 шт.
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    Асиглия таб. п/о плен., 100 мг, 28 шт.

    Цена 577 ₽
  • Таблетница на 7 дней/контейнер для таблеток и витаминов на 7 дней, Immunit
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    Таблетница на 7 дней/контейнер для таблеток и витаминов на 7 дней, Immunit

    Цена 149 ₽ вместо 189
  • Таблетница карманная Folca утро/день/вечер/ночь голубая
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    Таблетница карманная Folca утро/день/вечер/ночь голубая

    Цена 324 ₽ вместо 490
  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 192 ₽ вместо 350
  • Реклама
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  • Глюренорм таб., 30 мг, 60 шт.
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    Глюренорм таб., 30 мг, 60 шт.

    Цена 606 ₽ вместо 768
  • Контейнер для хранения/таблетница/кейс для таблеток
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    Контейнер для хранения/таблетница/кейс для таблеток

    Цена 372 ₽ вместо 699
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