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Описание

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Мелатонин Эвалар таб. п/о плен., 3 мг, 20 шт., 1 уп.

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4.6
(95)
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Количество штук в упаковке, шт.: 20

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Коротко о товаре

Артикул Маркета
3288321088
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.\u003Cbr\u003EПациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется."},{"name":"Побочные действия","value":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной Организации Здравоохранения:\u003Cbr\u003EОчень часто (≥1/10), часто (от ≥1/10 до \u003C1/10), нечасто (от ≥1/1000 до \u003C1/100), редко (от ≥1/10000 до \u003C1/1000), очень редко (\u003C1/10000), включая отдельные сообщения; частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможном).\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eредко: опоясывающий герпес.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003Eредко: лейкопения, тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eчастота неизвестна: реакции гиперчувствительности.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eредко: гипертриглицеридемия, гипокалиемия, гипонатриемия.\u003Cbr\u003EНарушение психики:\u003Cbr\u003Eнечасто: раздражительность, нервозность, беспокойство, бессонница, необычные сновидения, ночные кошмары, тревога;\u003Cbr\u003Eредко: перемены настроения, агрессия, ажитация, плаксивость, симптомы стресса, дезориентация, раннее утреннее пробуждение, повышение либидо, сниженное настроение, депрессия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто: мигрень, головная боль, вялость, психомоторная гиперактивность, головокружение, сонливость;\u003Cbr\u003Eредко: обморок, нарушение памяти, нарушение концентрации внимания, делирий, синдром \"беспокойных ног\", сновидное состояние, плохое качество сна, парестезии.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eредко: снижение остроты зрения, нечеткость зрения, повышенное слезотечение.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения:\u003Cbr\u003Eредко: вертиго, позиционное вертиго.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы:\u003Cbr\u003Eнечасто: артериальная гипертензия;\u003Cbr\u003Eредко: стенокардия напряжения, ощущение сердцебиения, приливы.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто: абдоминальная боль, абдоминальная боль в верхней части живота, диспепсия, язвенный стоматит, сухость во рту, тошнота;\u003Cbr\u003Eредко: гастроэзофагеальная болезнь, желудочно-кишечное нарушение или расстройство, буллезный стоматит, язвенный глоссит, рвота, усиление перистальтики, вздутие живота, гиперсекреция слюны, неприятный запах изо рта, абдоминальный дискомфорт, дискинезия желудка, гастрит.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003Eнечасто: гипербилирубинемия.\u003Cbr\u003EНарушение со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто: дерматит, потливость по ночам, зуд и генерализованный зуд, сыпь, сухость кожи;\u003Cbr\u003Eредко: экзема, эритема, дерматит рук, псориаз, генерализованная сыпь, зудящая сыпь, поражение ногтей;\u003Cbr\u003Eчастота неизвестна: отек Квинке, отек слизистой оболочки полости рта, отек языка.\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr\u003Eнечасто: боль в конечностях.\u003Cbr\u003Eредко: артрит, мышечный спазм, боль в шее, ночные судороги.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eнечасто: глюкозурия, протеинурия;\u003Cbr\u003Eредко: полиурия, гематурия, никтурия.\u003Cbr\u003EНарушения со стороны половых органов и грудной железы:\u003Cbr\u003Eнечасто: менопаузальные симптомы;\u003Cbr\u003Eредко: приапизм, простатит; частота неизвестна: галакторея.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто: астения, боль в груди;\u003Cbr\u003Eредко: утомляемость, боль, жажда.\u003Cbr\u003EЛабораторные и инструментальные данные:\u003Cbr\u003Eнечасто: отклонение от нормы лабораторных показателей функции печени, увеличение массы тела;\u003Cbr\u003Eредко: повышение активности \"печеночных\" трансаминаз, отклонение от нормы содержания электролитов в крови, отклонение от нормы результатов лабораторных тестов."},{"name":"Фармакологическое действие","value":"Мелатонин - синтетический аналог гормона шишковидного тела (эпифиза); синтезирован из аминокислот растительного происхождения.\u003Cbr\u003EОказывает адаптогенное, седативное, снотворное действие. Нормализует циркадные ритмы.\u003Cbr\u003EУвеличивает концентрацию гамма-аминомасляной кислоты (ГАМК) и серотонина в среднем мозге и гипоталамусе, изменяет активность пиридоксалькиназы, участвующей в синтезе ГАМК, дофамина и серотонина.\u003Cbr\u003EРегулирует цикл сон-бодрствование, суточные изменения локомоторной активности и температуры тела, положительно влияет на интеллектуально-мнестические функции мозга, на эмоционально-личностную сферу. Способствует организации биологического ритма и нормализации ночного сна, обладает снотворным эффектом. Улучшает качество сна, ускоряет засыпание, снижает число ночных пробуждений, улучшает самочувствие после утреннего пробуждения, не вызывает ощущение вялости, разбитости и усталости при пробуждении. Делает сновидения более яркими и эмоционально насыщенными.\u003Cbr\u003EАдаптирует организм к быстрой смене часовых поясов, снижает стрессовые реакции, регулирует нейроэндокринные функции.\u003Cbr\u003EАдаптирует организм метеочувствительных людей к изменениям погодных условий.\u003Cbr\u003EПроявляет иммуностимулирующие и антиоксидантные свойства.\u003Cbr\u003EНе вызывает привыкания и зависимости."},{"name":"Фармакологическая группа","value":"адаптогенное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С, в оригинальной упаковке.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"По имеющимся литературным данным, применение мелатонина в суточной дозировке до 300 мг не вызывало клинически значимых нежелательных реакций. При приеме мелатонина в дозах от 3000 мг до 6600 мг в течение нескольких недель наблюдались такие симптомы как гиперемия, спазмы в брюшной полости, диарея, головная боль, скотома. При применении очень высоких доз мелатонина (до 1 г) наблюдалась непроизвольная потеря сознания. При передозировке возможно развитие сонливости.\u003Cbr\u003EЛечение - промывание желудка и применение активированного угля, симптоматическая терапия. Клиренс активного вещества предполагается в пределах 12 часов после приема внутрь."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо воздержаться от управления транспортными средствами и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EВлияние различной степени почечной недостаточности на фармакокинетику мелатонина не изучено, поэтому таким пациентам мелатонин нужно применять с осторожностью.\u003Cbr\u003EВ период применения препарата Мелатонин Эвалар рекомендуется избегать пребывания на ярком свету.\u003Cbr\u003EНеобходимо проинформировать женщин, желающих забеременеть, о наличии у препарата слабого контрацептивного действия.\u003Cbr\u003EОтсутствуют клинические данные о применении мелатонина у больных с аутоиммунными заболеваниями, в связи с чем, применение у данной категории пациентов не рекомендуется. \u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих флувоксамин, который повышает концентрацию мелатонина за счет ингибирования его метаболизма изоферментами цитохрома Р450 (CYP): CYP1A2 и CYP2C19. Следует избегать такой комбинации.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих 5- и 8-метоксипсорален, который повышает концентрацию мелатонина вследствие ингибирования его метаболизма.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих циметидин, поскольку он повышает содержание мелатонина в плазме за счет ингибирования последнего.\u003Cbr\u003EКурение способно снизить концентрацию мелатонина за счет индукции изофермента CYP1A2.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих эстрогены (например, контрацептивы или заместительную гормональную терапию), которые увеличивают концентрацию мелатонина путем ингибирования их метаболизма изоферментами CYP1A1 и CYP1А2."},{"name":"Взаимодействие","value":"-Известно, что в концентрациях, значительно превышающих терапевтические, мелатонин индуцирует изофермент CYP3A in vitro. Клиническое значение этого явления до конца не выяснено. В случае развития признаков индукции следует рассмотреть вопрос о снижении дозы одновременно применяемых лекарственных средств.\u003Cbr\u003E- В концентрациях, значительно превышающих терапевтические, мелатонин не индуцирует изоферменты группы CYP1A in vitro. Следовательно, взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1А, по-видимому, незначимо.\u003Cbr\u003E- Метаболизм мелатонина, главным образом, опосредован изоферментами CYP1A. Следовательно, возможно взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1A.\u003Cbr\u003E- Ингибиторы изоферментов CYPA2, например, хинолоны, способны повышать экспозицию мелатонина.\u003Cbr\u003E- Индукторы изофермента CYP1A2, такие как карбамазепин и рифампицин, способны снижать плазменную концентрацию мелатонина.\u003Cbr\u003E- В современной литературе имеется множество данных, касающихся влияния агонистов/антагонистов адренергических и опиоидных рецепторов, антидепрессантов, ингибиторов простагландинов, бензодиазепинов, триптофана и алкоголя на секрецию эндогенного мелатонина. Исследования взаимного влияния этих препаратов на динамику или кинетику мелатонина не проводилось.\u003Cbr\u003EФармакодинамическое взаимодействие\u003Cbr\u003E- Во время приема мелатонина не следует употреблять алкоголь, так как он снижает эффективность препарата.\u003Cbr\u003E- Мелатонин потенцирует седативное действие бензодиазепиновых и небензодиазепиновых снотворных средств, таких как залеплон, золпидем и зопиклон. В ходе клинического исследования наблюдались четкие признаки транзиторного фармакодинамического взаимодействия между мелатонином и золпидемом спустя час после их приема. Комбинированное применение может приводить к прогрессирующему расстройству внимания, памяти и координации в сравнении с монотерапией золпидемом.\u003Cbr\u003E- В ходе исследований мелатонин назначался совместно с тиоридазином и имипрамином, препаратами, которые влияют на центральную нервную систему. Ни в одном из случаев не было выявлено клинически значимого фармакокинетического взаимодействия. Тем не менее, одновременное применение с мелатонином приводило к повышению ощущения спокойствия и к затруднениям в выполнении определенных заданий в сравнении с монотерапией имипрамином, а также к усилению чувства \"помутнения в голове\", в сравнении с монотерапией тиоридазином."},{"name":"Регистрационный номер","value":"ЛП-005295"},{"name":"Дата государственной регистрации","value":"14.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"Эвалар","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:13131221"]}}},{"name":"Изготовитель","value":"Эвалар"},{"name":"Фасовщик","value":"Эвалар"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мелатонин Эвалар","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:26106970"]}}},{"name":"Срок годности","value":"25 мес."}]}},"fullSpecsGrouped":{"14745580884343450704":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"головной мозг, нервная система"},{"name":"Назначение","value":"десинхроноз, нарушение сна"},{"name":"Показания к применению","value":"При расстройствах сна, в т.ч. обусловленных нарушением ритма \"сон-бодрствование\", таких как десинхроноз (резкая смена часовых поясов)."},{"name":"Противопоказания","value":"Гиперчувствительность к компонентам препарата, аутоиммунные заболевания, печеночная недостаточность, тяжелая почечная недостаточность, детский возраст до 18 лет, беременность, период грудного вскармливания."},{"name":"Состав","value":"На одну таблетку:\u003Cbr\u003EДействующее вещество: мелатонин - 3,00 мг.\u003Cbr\u003EВспомогательные вещества: целлюлоза микрокристаллическая - 172,72 мг, кальция гидрофосфат - 54,68 мг, кроскармеллоза натрия - 7,20 мг, кремния диоксид коллоидный - 1,20 мг, магния стеарат - 1,20 мг.\u003Cbr\u003EВспомогательные вещества оболочки: гипромеллоза (гидроксипропилметилцеллюлоза) - 4,00 мг, титана диоксид - 2,90 мг, полисорбат 80 - 1,32 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,89 мг, тальк - 0,89 мг."},{"name":"Действующее вещество","value":"Мелатонин"},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr\u003EПри нарушении сна - по 3 мг один раз в сутки за 30-40 минут до сна.\u003Cbr\u003EПри десинхронозе в качестве адаптогена при смене часовых поясов - за 1 день до перелета и в последующие 2-5 дней - по 3 мг за 30-40 минут до сна.\u003Cbr\u003EМаксимальная суточная доза - 6 мг.\u003Cbr\u003EПожилые пациенты\u003Cbr\u003EС возрастом происходит снижение метаболизма мелатонина, что необходимо учитывать при выборе режима дозирования для пожилых пациентов. С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.\u003Cbr\u003EПациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется."},{"name":"Побочные действия","value":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной Организации Здравоохранения:\u003Cbr\u003EОчень часто (≥1/10), часто (от ≥1/10 до \u003C1/10), нечасто (от ≥1/1000 до \u003C1/100), редко (от ≥1/10000 до \u003C1/1000), очень редко (\u003C1/10000), включая отдельные сообщения; частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможном).\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eредко: опоясывающий герпес.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003Eредко: лейкопения, тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eчастота неизвестна: реакции гиперчувствительности.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eредко: гипертриглицеридемия, гипокалиемия, гипонатриемия.\u003Cbr\u003EНарушение психики:\u003Cbr\u003Eнечасто: раздражительность, нервозность, беспокойство, бессонница, необычные сновидения, ночные кошмары, тревога;\u003Cbr\u003Eредко: перемены настроения, агрессия, ажитация, плаксивость, симптомы стресса, дезориентация, раннее утреннее пробуждение, повышение либидо, сниженное настроение, депрессия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто: мигрень, головная боль, вялость, психомоторная гиперактивность, головокружение, сонливость;\u003Cbr\u003Eредко: обморок, нарушение памяти, нарушение концентрации внимания, делирий, синдром \"беспокойных ног\", сновидное состояние, плохое качество сна, парестезии.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eредко: снижение остроты зрения, нечеткость зрения, повышенное слезотечение.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения:\u003Cbr\u003Eредко: вертиго, позиционное вертиго.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы:\u003Cbr\u003Eнечасто: артериальная гипертензия;\u003Cbr\u003Eредко: стенокардия напряжения, ощущение сердцебиения, приливы.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто: абдоминальная боль, абдоминальная боль в верхней части живота, диспепсия, язвенный стоматит, сухость во рту, тошнота;\u003Cbr\u003Eредко: гастроэзофагеальная болезнь, желудочно-кишечное нарушение или расстройство, буллезный стоматит, язвенный глоссит, рвота, усиление перистальтики, вздутие живота, гиперсекреция слюны, неприятный запах изо рта, абдоминальный дискомфорт, дискинезия желудка, гастрит.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003Eнечасто: гипербилирубинемия.\u003Cbr\u003EНарушение со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто: дерматит, потливость по ночам, зуд и генерализованный зуд, сыпь, сухость кожи;\u003Cbr\u003Eредко: экзема, эритема, дерматит рук, псориаз, генерализованная сыпь, зудящая сыпь, поражение ногтей;\u003Cbr\u003Eчастота неизвестна: отек Квинке, отек слизистой оболочки полости рта, отек языка.\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr\u003Eнечасто: боль в конечностях.\u003Cbr\u003Eредко: артрит, мышечный спазм, боль в шее, ночные судороги.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eнечасто: глюкозурия, протеинурия;\u003Cbr\u003Eредко: полиурия, гематурия, никтурия.\u003Cbr\u003EНарушения со стороны половых органов и грудной железы:\u003Cbr\u003Eнечасто: менопаузальные симптомы;\u003Cbr\u003Eредко: приапизм, простатит; частота неизвестна: галакторея.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто: астения, боль в груди;\u003Cbr\u003Eредко: утомляемость, боль, жажда.\u003Cbr\u003EЛабораторные и инструментальные данные:\u003Cbr\u003Eнечасто: отклонение от нормы лабораторных показателей функции печени, увеличение массы тела;\u003Cbr\u003Eредко: повышение активности \"печеночных\" трансаминаз, отклонение от нормы содержания электролитов в крови, отклонение от нормы результатов лабораторных тестов."},{"name":"Фармакологическое действие","value":"Мелатонин - синтетический аналог гормона шишковидного тела (эпифиза); синтезирован из аминокислот растительного происхождения.\u003Cbr\u003EОказывает адаптогенное, седативное, снотворное действие. Нормализует циркадные ритмы.\u003Cbr\u003EУвеличивает концентрацию гамма-аминомасляной кислоты (ГАМК) и серотонина в среднем мозге и гипоталамусе, изменяет активность пиридоксалькиназы, участвующей в синтезе ГАМК, дофамина и серотонина.\u003Cbr\u003EРегулирует цикл сон-бодрствование, суточные изменения локомоторной активности и температуры тела, положительно влияет на интеллектуально-мнестические функции мозга, на эмоционально-личностную сферу. Способствует организации биологического ритма и нормализации ночного сна, обладает снотворным эффектом. Улучшает качество сна, ускоряет засыпание, снижает число ночных пробуждений, улучшает самочувствие после утреннего пробуждения, не вызывает ощущение вялости, разбитости и усталости при пробуждении. Делает сновидения более яркими и эмоционально насыщенными.\u003Cbr\u003EАдаптирует организм к быстрой смене часовых поясов, снижает стрессовые реакции, регулирует нейроэндокринные функции.\u003Cbr\u003EАдаптирует организм метеочувствительных людей к изменениям погодных условий.\u003Cbr\u003EПроявляет иммуностимулирующие и антиоксидантные свойства.\u003Cbr\u003EНе вызывает привыкания и зависимости."},{"name":"Фармакологическая группа","value":"адаптогенное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С, в оригинальной упаковке.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"По имеющимся литературным данным, применение мелатонина в суточной дозировке до 300 мг не вызывало клинически значимых нежелательных реакций. При приеме мелатонина в дозах от 3000 мг до 6600 мг в течение нескольких недель наблюдались такие симптомы как гиперемия, спазмы в брюшной полости, диарея, головная боль, скотома. При применении очень высоких доз мелатонина (до 1 г) наблюдалась непроизвольная потеря сознания. При передозировке возможно развитие сонливости.\u003Cbr\u003EЛечение - промывание желудка и применение активированного угля, симптоматическая терапия. Клиренс активного вещества предполагается в пределах 12 часов после приема внутрь."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо воздержаться от управления транспортными средствами и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EВлияние различной степени почечной недостаточности на фармакокинетику мелатонина не изучено, поэтому таким пациентам мелатонин нужно применять с осторожностью.\u003Cbr\u003EВ период применения препарата Мелатонин Эвалар рекомендуется избегать пребывания на ярком свету.\u003Cbr\u003EНеобходимо проинформировать женщин, желающих забеременеть, о наличии у препарата слабого контрацептивного действия.\u003Cbr\u003EОтсутствуют клинические данные о применении мелатонина у больных с аутоиммунными заболеваниями, в связи с чем, применение у данной категории пациентов не рекомендуется. \u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих флувоксамин, который повышает концентрацию мелатонина за счет ингибирования его метаболизма изоферментами цитохрома Р450 (CYP): CYP1A2 и CYP2C19. Следует избегать такой комбинации.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих 5- и 8-метоксипсорален, который повышает концентрацию мелатонина вследствие ингибирования его метаболизма.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих циметидин, поскольку он повышает содержание мелатонина в плазме за счет ингибирования последнего.\u003Cbr\u003EКурение способно снизить концентрацию мелатонина за счет индукции изофермента CYP1A2.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих эстрогены (например, контрацептивы или заместительную гормональную терапию), которые увеличивают концентрацию мелатонина путем ингибирования их метаболизма изоферментами CYP1A1 и CYP1А2."},{"name":"Взаимодействие","value":"-Известно, что в концентрациях, значительно превышающих терапевтические, мелатонин индуцирует изофермент CYP3A in vitro. Клиническое значение этого явления до конца не выяснено. В случае развития признаков индукции следует рассмотреть вопрос о снижении дозы одновременно применяемых лекарственных средств.\u003Cbr\u003E- В концентрациях, значительно превышающих терапевтические, мелатонин не индуцирует изоферменты группы CYP1A in vitro. Следовательно, взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1А, по-видимому, незначимо.\u003Cbr\u003E- Метаболизм мелатонина, главным образом, опосредован изоферментами CYP1A. Следовательно, возможно взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1A.\u003Cbr\u003E- Ингибиторы изоферментов CYPA2, например, хинолоны, способны повышать экспозицию мелатонина.\u003Cbr\u003E- Индукторы изофермента CYP1A2, такие как карбамазепин и рифампицин, способны снижать плазменную концентрацию мелатонина.\u003Cbr\u003E- В современной литературе имеется множество данных, касающихся влияния агонистов/антагонистов адренергических и опиоидных рецепторов, антидепрессантов, ингибиторов простагландинов, бензодиазепинов, триптофана и алкоголя на секрецию эндогенного мелатонина. Исследования взаимного влияния этих препаратов на динамику или кинетику мелатонина не проводилось.\u003Cbr\u003EФармакодинамическое взаимодействие\u003Cbr\u003E- Во время приема мелатонина не следует употреблять алкоголь, так как он снижает эффективность препарата.\u003Cbr\u003E- Мелатонин потенцирует седативное действие бензодиазепиновых и небензодиазепиновых снотворных средств, таких как залеплон, золпидем и зопиклон. В ходе клинического исследования наблюдались четкие признаки транзиторного фармакодинамического взаимодействия между мелатонином и золпидемом спустя час после их приема. Комбинированное применение может приводить к прогрессирующему расстройству внимания, памяти и координации в сравнении с монотерапией золпидемом.\u003Cbr\u003E- В ходе исследований мелатонин назначался совместно с тиоридазином и имипрамином, препаратами, которые влияют на центральную нервную систему. Ни в одном из случаев не было выявлено клинически значимого фармакокинетического взаимодействия. Тем не менее, одновременное применение с мелатонином приводило к повышению ощущения спокойствия и к затруднениям в выполнении определенных заданий в сравнении с монотерапией имипрамином, а также к усилению чувства \"помутнения в голове\", в сравнении с монотерапией тиоридазином."},{"name":"Регистрационный номер","value":"ЛП-005295"},{"name":"Дата государственной регистрации","value":"14.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"Эвалар"},{"name":"Изготовитель","value":"Эвалар"},{"name":"Фасовщик","value":"Эвалар"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мелатонин Эвалар"},{"name":"Срок годности","value":"25 мес."}]}],"transitionId":"tr_1195534707891509736"}}}}
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Цена с картой Яндекс Пэй:400 ₽

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  • 7 июня, курьер Маркета • 249 ₽
POLZAru
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  • Глицин+Мелатонин Эвалар таб. п/языч., 20 шт.
    –2 %
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    Глицин+Мелатонин Эвалар таб. п/языч., 20 шт.

    Рейтинг товара: 4.5 из 5
    на основе 52 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 754 ₽ вместо 770
    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Эвалар таб. п/языч., 20 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  • Гармония сна капс., 0.36 г
    –54 %
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    Гармония сна капс., 0.36 г

    Рейтинг товара: 4.4 из 5
    на основе 57 оценок
    Цена 341 ₽ вместо 742
    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  • Формула Спокойствия Триптофан капс., 15 шт.
    –20 %
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    Формула Спокойствия Триптофан капс., 15 шт.

    Рейтинг товара: 4.6 из 5
    на основе 304 оценки
    Цена 338 ₽ вместо 422
    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  • Формула сна экспресс таб. д/рассас., 40 шт.
    –10 %
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    Формула сна экспресс таб. д/рассас., 40 шт.

    Рейтинг товара: 4.4 из 5
    на основе 76 оценок
    Цена 396 ₽ вместо 440
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  • Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.
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    Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.

    Рейтинг товара: 4.5 из 5
    на основе 51 оценка
    Цена 575 ₽
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  • Сонные+ таб., 30 шт., 1 уп.
    –31 %
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    Сонные+ таб., 30 шт., 1 уп.

    Рейтинг товара: 4.1 из 5
    на основе 146 оценок
    Цена 275 ₽ вместо 399
    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таб., 30 шт., 1 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  • Мелаксен таб., 3 мг, 24 шт.
    –21 %
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    Мелаксен таб., 3 мг, 24 шт.

    Рейтинг товара: 4.8 из 5
    на основе 24 оценки
    Цена 757 ₽ вместо 959
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  • Соннован таб. п/о плен., 3 мг, 30 шт.
    –2 %
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    Соннован таб. п/о плен., 3 мг, 30 шт.

    Рейтинг товара: 4.3 из 5
    на основе 3 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 560 ₽ вместо 572
    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таб. п/о плен., 3 мг, 30 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  • Формула сна усиленная фито-мелатонином капс., 30 шт.
    ВАМ–30 %
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    Формула сна усиленная фито-мелатонином капс., 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 34 оценки
    Цена 530 ₽ вместо 760
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  • Велсон таб. п/о плен., 3 мг, 30 шт.
    –21 %
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    Велсон таб. п/о плен., 3 мг, 30 шт.

    Рейтинг товара: 4.3 из 5
    на основе 16 оценок
    Цена 622 ₽ вместо 788
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  • Донормил таб. п/о плен., 15 мг, 30 шт.
    –10 %
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    Донормил таб. п/о плен., 15 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 49 оценок
    Цена 433 ₽ вместо 483
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Инструкция

Показания к применению

При расстройствах сна, в т.ч. обусловленных нарушением ритма "сон-бодрствование", таких как десинхроноз (резкая смена часовых поясов).

Противопоказания

Гиперчувствительность к компонентам препарата, аутоиммунные заболевания, печеночная недостаточность, тяжелая почечная недостаточность, детский возраст до 18 лет, беременность, период грудного вскармливания.

Способ применения и дозы

Внутрь.
При нарушении сна - по 3 мг один раз в сутки за 30-40 минут до сна.
При десинхронозе в качестве адаптогена при смене часовых поясов - за 1 день до перелета и в последующие 2-5 дней - по 3 мг за 30-40 минут до сна.
Максимальная суточная доза - 6 мг.
Пожилые пациенты
С возрастом происходит снижение метаболизма мелатонина, что необходимо учитывать при выборе режима дозирования для пожилых пациентов. С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.
Пациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется.
Полная инструкция
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Мелатонин Эвалар таб. п/о плен.
Мелатонин Эвалар таб. п/о плен., 3 мг, 20 шт., 1 уп.
4.6
(95)
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13 вопросов
Инструкция

Цена с картой Яндекс Пэй:400 ₽

Скидка: 2%
–2 %
Вместо: 408 ₽
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4.6
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У продавца:95 оценок·24 отзыва
У всех продавцов:701 оценка·289 отзывов
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user avatar
4 месяца назад • Andry Goryachev • Куплен на Маркете
Комментарий: Пользую около года-возраст даёт себя знать. Метода употребления-отбой 21-00,таблетку рассосать за 20 минут до желаемого времени засыпания. Нормальный сон до 7....8 утра. Помогает в 80% случаев.
user avatar
9 месяцев назад • Ольга Т. • Куплен на Маркете
Комментарий: Супер вещь! Выпиваешь и после 30-40 минут обязательно нужно лечь спать, или хотя бы просто полежать закрытыми глазами если не спится, уснëте в любом случае, если соблюдать это правило, тогда действует очень эффективно. Спишь до утра сладким сном и при этом утром чувствуешь себя бодро, наполненным энергией и силами.
user avatar
2 месяца назад • katurs • Куплен на Маркете
Достоинства: Лёгкий снотворный эффект. Препарат не вызывает привыкания. Отпускается без рецепта.
Недостатки: Очевидных не нашел.
Комментарий: Надеюсь и дальше смогу пользоваться при необходимости.
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    Цена 430 ₽ вместо 510
  • Глицин+Мелатонин Эвалар таб. п/языч., 20 шт.
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    Глицин+Мелатонин Эвалар таб. п/языч., 20 шт.

    Цена 754 ₽ вместо 770
  • Мелаксен таб., 3 мг, 24 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748522_4/content/content/toggleWishlist":{"skuId":"228007851","productId":1404748522,"offerId":"bfDQE8A51M1eiEUJxXySSw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCOqF650FEKu/3GwY99zQByDt2cEH","sign":"vdqgn2neaSgrS7BmkHBLNOhxRnbBLXl3eOZxdOC+eHo="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748522_4/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Мелаксен таб., 3 мг, 24 шт.

    Цена 757 ₽ вместо 959
  • Эвалар Витамин Д3 максимум 2000 МЕ 120 капсул
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1821930825_5/content/content/gallery":{"title":"Эвалар Витамин Д3 максимум 2000 МЕ 120 капсул","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/11396862/2a0000018c5e293a6ff582a49ff64afc45e1/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/11396862/2a0000018c5e293a6ff582a49ff64afc45e1/120x160 120w, https://avatars.mds.yandex.net/get-mpic/11396862/2a0000018c5e293a6ff582a49ff64afc45e1/180x240 180w, https://avatars.mds.yandex.net/get-mpic/11396862/2a0000018c5e293a6ff582a49ff64afc45e1/240x320 240w, https://avatars.mds.yandex.net/get-mpic/11396862/2a0000018c5e293a6ff582a49ff64afc45e1/300x400 300w, https://avatars.mds.yandex.net/get-mpic/11396862/2a0000018c5e293a6ff582a49ff64afc45e1/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5279099/img_id3016899862245543426.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5279099/img_id3016899862245543426.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5279099/img_id3016899862245543426.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5279099/img_id3016899862245543426.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5279099/img_id3016899862245543426.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5279099/img_id3016899862245543426.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4055688/img_id3564450331745746394.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4055688/img_id3564450331745746394.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4055688/img_id3564450331745746394.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4055688/img_id3564450331745746394.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4055688/img_id3564450331745746394.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4055688/img_id3564450331745746394.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMnq4eQGEJ2Ku+r7AhjVu6EGIJnDBQ==","sign":"M63H6R22pXFGo0LfucT6Zwz56dQqnoDGtx+E13AmJgk="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1821930825_5/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1821930825_5/content/content/toggleWishlist":{"skuId":"101960303901","productId":1821930825,"offerId":"3F5uw7oAP-j4IZvqpoD1_w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMnq4eQGEJ2Ku+r7AhjVu6EGIJnDBQ==","sign":"M63H6R22pXFGo0LfucT6Zwz56dQqnoDGtx+E13AmJgk="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1821930825_5/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эвалар Витамин Д3 максимум 2000 МЕ 120 капсул

    Цена 531 ₽ вместо 596
  • Формула Спокойствия Триптофан капс., 15 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748657_6/content/content/gallery":{"title":"Формула Спокойствия Триптофан капс., 15 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5235242/img_id5941129491281735265.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5235242/img_id5941129491281735265.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5235242/img_id5941129491281735265.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5235242/img_id5941129491281735265.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5235242/img_id5941129491281735265.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5235242/img_id5941129491281735265.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4383514/img_id1277369363911902097.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4383514/img_id1277369363911902097.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4383514/img_id1277369363911902097.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4383514/img_id1277369363911902097.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4383514/img_id1277369363911902097.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4383514/img_id1277369363911902097.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCPGG650FEOH/uH4Y1buhBiDt2cEH","sign":"K4MIlH1gHPO91Q4EHVpLYpqR2VPNxabbkozsz3IMTSo="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748657_6/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748657_6/content/content/toggleWishlist":{"skuId":"265175009","productId":1404748657,"offerId":"W-J_DvDkdHFhyIOsinWsOA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCPGG650FEOH/uH4Y1buhBiDt2cEH","sign":"K4MIlH1gHPO91Q4EHVpLYpqR2VPNxabbkozsz3IMTSo="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748657_6/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Формула Спокойствия Триптофан капс., 15 шт.

    Цена 338 ₽ вместо 422
  • Витамин Д3 + К2 таб. жев., 1200 МЕ, 0.22 г, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:784694470_7/content/content/toggleWishlist":{"skuId":"101321467759","productId":784694470,"offerId":"__0hq5OiCL4bYIYHlYxcEQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMb5lfYCEO/O67n5AhjVu6EGIJnDBQ==","sign":"2zaTjp3VUNrfhGSMo2125EKxDWeGqMy4GG/YY5NU62s="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:784694470_7/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Витамин Д3 + К2 таб. жев., 1200 МЕ, 0.22 г, 60 шт.

    Цена 303 ₽ вместо 340
  • Реклама
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  • Магний хелат таб., 85 мл, 1.4 г, 60 шт.
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    Магний хелат таб., 85 мл, 1.4 г, 60 шт.

    Цена 1 027 ₽ вместо 1 166
  • Соннован таб. п/о плен., 3 мг, 30 шт.
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    Соннован таб. п/о плен., 3 мг, 30 шт.

    Цена 560 ₽ вместо 572
  • Гармония сна капс., 0.36 г
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:668070085_11/content/content/toggleWishlist":{"skuId":"101769018728","productId":668070085,"offerId":"mrKeEQUdw6wLJV5wkePTrQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCMXhx74CEOj6n4/7Ahigu/YFIO3ZwQc=","sign":"qrPGn983NqTXGJaUq05kOBr+xTyG+RUV4kSzlmhNBsU="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:668070085_11/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гармония сна капс., 0.36 г

    Цена 341 ₽ вместо 742
  • Формула сна экспресс таб. д/рассас., 40 шт.
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    Формула сна экспресс таб. д/рассас., 40 шт.

    Цена 396 ₽ вместо 440
  • Сонные+ таб., 30 шт., 1 уп.
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    Сонные+ таб., 30 шт., 1 уп.

    Цена 275 ₽ вместо 399
  • Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.
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    Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.

    Цена 575 ₽
  • Велсон таб. п/о плен., 3 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172995_15/content/content/gallery":{"title":"Велсон таб. п/о плен., 3 мг, 30 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4809526/img_id7855102867179115399.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4809526/img_id7855102867179115399.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4809526/img_id7855102867179115399.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4809526/img_id7855102867179115399.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4809526/img_id7855102867179115399.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4809526/img_id7855102867179115399.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4579830/img_id6290924945144069485.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4579830/img_id6290924945144069485.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4579830/img_id6290924945144069485.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4579830/img_id6290924945144069485.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4579830/img_id6290924945144069485.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4579830/img_id6290924945144069485.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1862611/img_id1509632878502536911.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1862611/img_id1509632878502536911.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1862611/img_id1509632878502536911.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1862611/img_id1509632878502536911.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1862611/img_id1509632878502536911.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1862611/img_id1509632878502536911.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5234569/img_id344547201238160455.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5234569/img_id344547201238160455.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5234569/img_id344547201238160455.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5234569/img_id344547201238160455.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5234569/img_id344547201238160455.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5234569/img_id344547201238160455.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4904293/img_id4224240845710504027.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4904293/img_id4224240845710504027.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4904293/img_id4224240845710504027.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4904293/img_id4224240845710504027.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4904293/img_id4224240845710504027.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4904293/img_id4224240845710504027.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1597983/img_id4718858584295870110.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1597983/img_id4718858584295870110.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1597983/img_id4718858584295870110.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1597983/img_id4718858584295870110.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1597983/img_id4718858584295870110.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1597983/img_id4718858584295870110.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMOI888GEMDZgoACGJ/mowcg7dnBBw==","sign":"Ua++iZJ4r++93HgR7RbBMabzNq43cSRMQqj2PHKbmAY="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172995_15/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172995_15/content/content/toggleWishlist":{"skuId":"536915136","productId":1778172995,"offerId":"UPupH3u-bL4CUojbKhoj7A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMOI888GEMDZgoACGJ/mowcg7dnBBw==","sign":"Ua++iZJ4r++93HgR7RbBMabzNq43cSRMQqj2PHKbmAY="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172995_15/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Велсон таб. п/о плен., 3 мг, 30 шт.

    Цена 622 ₽ вместо 788
  • Формула сна усиленная фито-мелатонином капс., 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172926_16/content/content/gallery":{"title":"Формула сна усиленная фито-мелатонином капс., 30 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCP6H888GEJPFtn4Y1buhBiDt2cEH","sign":"KIASPgFVVIPTsODsxJmJpMLyWhVEWqzFXgw99GOYots="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172926_16/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Формула сна усиленная фито-мелатонином капс., 30 шт.

    Цена 530 ₽ вместо 760
  • Витамин Д3 + К2 / VITAMIN D3+К2 2000 МЕ 250 мг aTech nutrition 120 капсул
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1806227923_17/content/content/toggleWishlist":{"skuId":"101899112874","productId":1806227923,"offerId":"Uz88Osz1nIGXcLF79pHbMg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCNOzo90GEKqjpM37AhiXpekGIJnDBQ==","sign":"r+bXws22PkhiE0nz3S/TtmWKSFhgGjPDJvRuECMnyFs="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1806227923_17/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Витамин Д3 + К2 / VITAMIN D3+К2 2000 МЕ 250 мг aTech nutrition 120 капсул

    Цена 354 ₽ вместо 481
  • Донормил таб. п/о плен., 15 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228046100_18/content/content/toggleWishlist":{"skuId":"101594757795","productId":228046100,"offerId":"v3e4ESNVjMkPMQRRDqpwJA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ3o6Ihary6KACEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCJTq3mwQo/WTvPoCGJ3h0Acg7dnBBw==","sign":"BJWFWuOtUiydZLLRQbtI2ePbTtSoWKCZqCLIVqeOpaw="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228046100_18/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Донормил таб. п/о плен., 15 мг, 30 шт.

    Цена 433 ₽ вместо 483
  • Эвалар Таурин 1000 мг 60 таблеток
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    Эвалар Таурин 1000 мг 60 таблеток

    Цена 621 ₽ вместо 660
  • Панангин таб. п/о плен., 50 шт.
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    Панангин таб. п/о плен., 50 шт.

    Цена 188 ₽ вместо 234
  • Реклама
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  • Витамин С таб. шип., 900 мг, 20 шт., цитрусовый
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    Витамин С таб. шип., 900 мг, 20 шт., цитрусовый

    Цена 469 ₽ вместо 474
  • Эрмиталь капc. кш/раств., 10000 ЕД, 20 шт.
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    Эрмиталь капc. кш/раств., 10000 ЕД, 20 шт.

    Цена 207 ₽ вместо 209
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