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Мелатонин Эвалар таб. п/о плен., 3 мг, 20 шт., 1 уп.

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4.6
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Количество штук в упаковке, шт.: 20

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Коротко о товаре

Артикул Маркета
3288321088
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.\u003Cbr\u003EПациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется."},{"name":"Побочные действия","value":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной Организации Здравоохранения:\u003Cbr\u003EОчень часто (≥1/10), часто (от ≥1/10 до \u003C1/10), нечасто (от ≥1/1000 до \u003C1/100), редко (от ≥1/10000 до \u003C1/1000), очень редко (\u003C1/10000), включая отдельные сообщения; частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможном).\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eредко: опоясывающий герпес.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003Eредко: лейкопения, тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eчастота неизвестна: реакции гиперчувствительности.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eредко: гипертриглицеридемия, гипокалиемия, гипонатриемия.\u003Cbr\u003EНарушение психики:\u003Cbr\u003Eнечасто: раздражительность, нервозность, беспокойство, бессонница, необычные сновидения, ночные кошмары, тревога;\u003Cbr\u003Eредко: перемены настроения, агрессия, ажитация, плаксивость, симптомы стресса, дезориентация, раннее утреннее пробуждение, повышение либидо, сниженное настроение, депрессия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто: мигрень, головная боль, вялость, психомоторная гиперактивность, головокружение, сонливость;\u003Cbr\u003Eредко: обморок, нарушение памяти, нарушение концентрации внимания, делирий, синдром \"беспокойных ног\", сновидное состояние, плохое качество сна, парестезии.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eредко: снижение остроты зрения, нечеткость зрения, повышенное слезотечение.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения:\u003Cbr\u003Eредко: вертиго, позиционное вертиго.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы:\u003Cbr\u003Eнечасто: артериальная гипертензия;\u003Cbr\u003Eредко: стенокардия напряжения, ощущение сердцебиения, приливы.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто: абдоминальная боль, абдоминальная боль в верхней части живота, диспепсия, язвенный стоматит, сухость во рту, тошнота;\u003Cbr\u003Eредко: гастроэзофагеальная болезнь, желудочно-кишечное нарушение или расстройство, буллезный стоматит, язвенный глоссит, рвота, усиление перистальтики, вздутие живота, гиперсекреция слюны, неприятный запах изо рта, абдоминальный дискомфорт, дискинезия желудка, гастрит.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003Eнечасто: гипербилирубинемия.\u003Cbr\u003EНарушение со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто: дерматит, потливость по ночам, зуд и генерализованный зуд, сыпь, сухость кожи;\u003Cbr\u003Eредко: экзема, эритема, дерматит рук, псориаз, генерализованная сыпь, зудящая сыпь, поражение ногтей;\u003Cbr\u003Eчастота неизвестна: отек Квинке, отек слизистой оболочки полости рта, отек языка.\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr\u003Eнечасто: боль в конечностях.\u003Cbr\u003Eредко: артрит, мышечный спазм, боль в шее, ночные судороги.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eнечасто: глюкозурия, протеинурия;\u003Cbr\u003Eредко: полиурия, гематурия, никтурия.\u003Cbr\u003EНарушения со стороны половых органов и грудной железы:\u003Cbr\u003Eнечасто: менопаузальные симптомы;\u003Cbr\u003Eредко: приапизм, простатит; частота неизвестна: галакторея.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто: астения, боль в груди;\u003Cbr\u003Eредко: утомляемость, боль, жажда.\u003Cbr\u003EЛабораторные и инструментальные данные:\u003Cbr\u003Eнечасто: отклонение от нормы лабораторных показателей функции печени, увеличение массы тела;\u003Cbr\u003Eредко: повышение активности \"печеночных\" трансаминаз, отклонение от нормы содержания электролитов в крови, отклонение от нормы результатов лабораторных тестов."},{"name":"Фармакологическое действие","value":"Мелатонин - синтетический аналог гормона шишковидного тела (эпифиза); синтезирован из аминокислот растительного происхождения.\u003Cbr\u003EОказывает адаптогенное, седативное, снотворное действие. Нормализует циркадные ритмы.\u003Cbr\u003EУвеличивает концентрацию гамма-аминомасляной кислоты (ГАМК) и серотонина в среднем мозге и гипоталамусе, изменяет активность пиридоксалькиназы, участвующей в синтезе ГАМК, дофамина и серотонина.\u003Cbr\u003EРегулирует цикл сон-бодрствование, суточные изменения локомоторной активности и температуры тела, положительно влияет на интеллектуально-мнестические функции мозга, на эмоционально-личностную сферу. Способствует организации биологического ритма и нормализации ночного сна, обладает снотворным эффектом. Улучшает качество сна, ускоряет засыпание, снижает число ночных пробуждений, улучшает самочувствие после утреннего пробуждения, не вызывает ощущение вялости, разбитости и усталости при пробуждении. Делает сновидения более яркими и эмоционально насыщенными.\u003Cbr\u003EАдаптирует организм к быстрой смене часовых поясов, снижает стрессовые реакции, регулирует нейроэндокринные функции.\u003Cbr\u003EАдаптирует организм метеочувствительных людей к изменениям погодных условий.\u003Cbr\u003EПроявляет иммуностимулирующие и антиоксидантные свойства.\u003Cbr\u003EНе вызывает привыкания и зависимости."},{"name":"Фармакологическая группа","value":"адаптогенное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С, в оригинальной упаковке.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"По имеющимся литературным данным, применение мелатонина в суточной дозировке до 300 мг не вызывало клинически значимых нежелательных реакций. При приеме мелатонина в дозах от 3000 мг до 6600 мг в течение нескольких недель наблюдались такие симптомы как гиперемия, спазмы в брюшной полости, диарея, головная боль, скотома. При применении очень высоких доз мелатонина (до 1 г) наблюдалась непроизвольная потеря сознания. При передозировке возможно развитие сонливости.\u003Cbr\u003EЛечение - промывание желудка и применение активированного угля, симптоматическая терапия. Клиренс активного вещества предполагается в пределах 12 часов после приема внутрь."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо воздержаться от управления транспортными средствами и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EВлияние различной степени почечной недостаточности на фармакокинетику мелатонина не изучено, поэтому таким пациентам мелатонин нужно применять с осторожностью.\u003Cbr\u003EВ период применения препарата Мелатонин Эвалар рекомендуется избегать пребывания на ярком свету.\u003Cbr\u003EНеобходимо проинформировать женщин, желающих забеременеть, о наличии у препарата слабого контрацептивного действия.\u003Cbr\u003EОтсутствуют клинические данные о применении мелатонина у больных с аутоиммунными заболеваниями, в связи с чем, применение у данной категории пациентов не рекомендуется. \u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих флувоксамин, который повышает концентрацию мелатонина за счет ингибирования его метаболизма изоферментами цитохрома Р450 (CYP): CYP1A2 и CYP2C19. Следует избегать такой комбинации.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих 5- и 8-метоксипсорален, который повышает концентрацию мелатонина вследствие ингибирования его метаболизма.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих циметидин, поскольку он повышает содержание мелатонина в плазме за счет ингибирования последнего.\u003Cbr\u003EКурение способно снизить концентрацию мелатонина за счет индукции изофермента CYP1A2.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих эстрогены (например, контрацептивы или заместительную гормональную терапию), которые увеличивают концентрацию мелатонина путем ингибирования их метаболизма изоферментами CYP1A1 и CYP1А2."},{"name":"Взаимодействие","value":"-Известно, что в концентрациях, значительно превышающих терапевтические, мелатонин индуцирует изофермент CYP3A in vitro. Клиническое значение этого явления до конца не выяснено. В случае развития признаков индукции следует рассмотреть вопрос о снижении дозы одновременно применяемых лекарственных средств.\u003Cbr\u003E- В концентрациях, значительно превышающих терапевтические, мелатонин не индуцирует изоферменты группы CYP1A in vitro. Следовательно, взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1А, по-видимому, незначимо.\u003Cbr\u003E- Метаболизм мелатонина, главным образом, опосредован изоферментами CYP1A. Следовательно, возможно взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1A.\u003Cbr\u003E- Ингибиторы изоферментов CYPA2, например, хинолоны, способны повышать экспозицию мелатонина.\u003Cbr\u003E- Индукторы изофермента CYP1A2, такие как карбамазепин и рифампицин, способны снижать плазменную концентрацию мелатонина.\u003Cbr\u003E- В современной литературе имеется множество данных, касающихся влияния агонистов/антагонистов адренергических и опиоидных рецепторов, антидепрессантов, ингибиторов простагландинов, бензодиазепинов, триптофана и алкоголя на секрецию эндогенного мелатонина. Исследования взаимного влияния этих препаратов на динамику или кинетику мелатонина не проводилось.\u003Cbr\u003EФармакодинамическое взаимодействие\u003Cbr\u003E- Во время приема мелатонина не следует употреблять алкоголь, так как он снижает эффективность препарата.\u003Cbr\u003E- Мелатонин потенцирует седативное действие бензодиазепиновых и небензодиазепиновых снотворных средств, таких как залеплон, золпидем и зопиклон. В ходе клинического исследования наблюдались четкие признаки транзиторного фармакодинамического взаимодействия между мелатонином и золпидемом спустя час после их приема. Комбинированное применение может приводить к прогрессирующему расстройству внимания, памяти и координации в сравнении с монотерапией золпидемом.\u003Cbr\u003E- В ходе исследований мелатонин назначался совместно с тиоридазином и имипрамином, препаратами, которые влияют на центральную нервную систему. Ни в одном из случаев не было выявлено клинически значимого фармакокинетического взаимодействия. Тем не менее, одновременное применение с мелатонином приводило к повышению ощущения спокойствия и к затруднениям в выполнении определенных заданий в сравнении с монотерапией имипрамином, а также к усилению чувства \"помутнения в голове\", в сравнении с монотерапией тиоридазином."},{"name":"Регистрационный номер","value":"ЛП-005295"},{"name":"Дата государственной регистрации","value":"14.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"Эвалар","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:13131221"]}}},{"name":"Изготовитель","value":"Эвалар"},{"name":"Фасовщик","value":"Эвалар"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мелатонин Эвалар","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:26106970"]}}},{"name":"Срок годности","value":"25 мес."}]}},"fullSpecsGrouped":{"14745580884343450704":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"головной мозг, нервная система"},{"name":"Назначение","value":"десинхроноз, нарушение сна"},{"name":"Показания к применению","value":"При расстройствах сна, в т.ч. обусловленных нарушением ритма \"сон-бодрствование\", таких как десинхроноз (резкая смена часовых поясов)."},{"name":"Противопоказания","value":"Гиперчувствительность к компонентам препарата, аутоиммунные заболевания, печеночная недостаточность, тяжелая почечная недостаточность, детский возраст до 18 лет, беременность, период грудного вскармливания."},{"name":"Состав","value":"На одну таблетку:\u003Cbr\u003EДействующее вещество: мелатонин - 3,00 мг.\u003Cbr\u003EВспомогательные вещества: целлюлоза микрокристаллическая - 172,72 мг, кальция гидрофосфат - 54,68 мг, кроскармеллоза натрия - 7,20 мг, кремния диоксид коллоидный - 1,20 мг, магния стеарат - 1,20 мг.\u003Cbr\u003EВспомогательные вещества оболочки: гипромеллоза (гидроксипропилметилцеллюлоза) - 4,00 мг, титана диоксид - 2,90 мг, полисорбат 80 - 1,32 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,89 мг, тальк - 0,89 мг."},{"name":"Действующее вещество","value":"Мелатонин"},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr\u003EПри нарушении сна - по 3 мг один раз в сутки за 30-40 минут до сна.\u003Cbr\u003EПри десинхронозе в качестве адаптогена при смене часовых поясов - за 1 день до перелета и в последующие 2-5 дней - по 3 мг за 30-40 минут до сна.\u003Cbr\u003EМаксимальная суточная доза - 6 мг.\u003Cbr\u003EПожилые пациенты\u003Cbr\u003EС возрастом происходит снижение метаболизма мелатонина, что необходимо учитывать при выборе режима дозирования для пожилых пациентов. С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.\u003Cbr\u003EПациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется."},{"name":"Побочные действия","value":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной Организации Здравоохранения:\u003Cbr\u003EОчень часто (≥1/10), часто (от ≥1/10 до \u003C1/10), нечасто (от ≥1/1000 до \u003C1/100), редко (от ≥1/10000 до \u003C1/1000), очень редко (\u003C1/10000), включая отдельные сообщения; частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможном).\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eредко: опоясывающий герпес.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003Eредко: лейкопения, тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eчастота неизвестна: реакции гиперчувствительности.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eредко: гипертриглицеридемия, гипокалиемия, гипонатриемия.\u003Cbr\u003EНарушение психики:\u003Cbr\u003Eнечасто: раздражительность, нервозность, беспокойство, бессонница, необычные сновидения, ночные кошмары, тревога;\u003Cbr\u003Eредко: перемены настроения, агрессия, ажитация, плаксивость, симптомы стресса, дезориентация, раннее утреннее пробуждение, повышение либидо, сниженное настроение, депрессия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто: мигрень, головная боль, вялость, психомоторная гиперактивность, головокружение, сонливость;\u003Cbr\u003Eредко: обморок, нарушение памяти, нарушение концентрации внимания, делирий, синдром \"беспокойных ног\", сновидное состояние, плохое качество сна, парестезии.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eредко: снижение остроты зрения, нечеткость зрения, повышенное слезотечение.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения:\u003Cbr\u003Eредко: вертиго, позиционное вертиго.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы:\u003Cbr\u003Eнечасто: артериальная гипертензия;\u003Cbr\u003Eредко: стенокардия напряжения, ощущение сердцебиения, приливы.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто: абдоминальная боль, абдоминальная боль в верхней части живота, диспепсия, язвенный стоматит, сухость во рту, тошнота;\u003Cbr\u003Eредко: гастроэзофагеальная болезнь, желудочно-кишечное нарушение или расстройство, буллезный стоматит, язвенный глоссит, рвота, усиление перистальтики, вздутие живота, гиперсекреция слюны, неприятный запах изо рта, абдоминальный дискомфорт, дискинезия желудка, гастрит.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003Eнечасто: гипербилирубинемия.\u003Cbr\u003EНарушение со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто: дерматит, потливость по ночам, зуд и генерализованный зуд, сыпь, сухость кожи;\u003Cbr\u003Eредко: экзема, эритема, дерматит рук, псориаз, генерализованная сыпь, зудящая сыпь, поражение ногтей;\u003Cbr\u003Eчастота неизвестна: отек Квинке, отек слизистой оболочки полости рта, отек языка.\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr\u003Eнечасто: боль в конечностях.\u003Cbr\u003Eредко: артрит, мышечный спазм, боль в шее, ночные судороги.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eнечасто: глюкозурия, протеинурия;\u003Cbr\u003Eредко: полиурия, гематурия, никтурия.\u003Cbr\u003EНарушения со стороны половых органов и грудной железы:\u003Cbr\u003Eнечасто: менопаузальные симптомы;\u003Cbr\u003Eредко: приапизм, простатит; частота неизвестна: галакторея.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто: астения, боль в груди;\u003Cbr\u003Eредко: утомляемость, боль, жажда.\u003Cbr\u003EЛабораторные и инструментальные данные:\u003Cbr\u003Eнечасто: отклонение от нормы лабораторных показателей функции печени, увеличение массы тела;\u003Cbr\u003Eредко: повышение активности \"печеночных\" трансаминаз, отклонение от нормы содержания электролитов в крови, отклонение от нормы результатов лабораторных тестов."},{"name":"Фармакологическое действие","value":"Мелатонин - синтетический аналог гормона шишковидного тела (эпифиза); синтезирован из аминокислот растительного происхождения.\u003Cbr\u003EОказывает адаптогенное, седативное, снотворное действие. Нормализует циркадные ритмы.\u003Cbr\u003EУвеличивает концентрацию гамма-аминомасляной кислоты (ГАМК) и серотонина в среднем мозге и гипоталамусе, изменяет активность пиридоксалькиназы, участвующей в синтезе ГАМК, дофамина и серотонина.\u003Cbr\u003EРегулирует цикл сон-бодрствование, суточные изменения локомоторной активности и температуры тела, положительно влияет на интеллектуально-мнестические функции мозга, на эмоционально-личностную сферу. Способствует организации биологического ритма и нормализации ночного сна, обладает снотворным эффектом. Улучшает качество сна, ускоряет засыпание, снижает число ночных пробуждений, улучшает самочувствие после утреннего пробуждения, не вызывает ощущение вялости, разбитости и усталости при пробуждении. Делает сновидения более яркими и эмоционально насыщенными.\u003Cbr\u003EАдаптирует организм к быстрой смене часовых поясов, снижает стрессовые реакции, регулирует нейроэндокринные функции.\u003Cbr\u003EАдаптирует организм метеочувствительных людей к изменениям погодных условий.\u003Cbr\u003EПроявляет иммуностимулирующие и антиоксидантные свойства.\u003Cbr\u003EНе вызывает привыкания и зависимости."},{"name":"Фармакологическая группа","value":"адаптогенное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С, в оригинальной упаковке.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"По имеющимся литературным данным, применение мелатонина в суточной дозировке до 300 мг не вызывало клинически значимых нежелательных реакций. При приеме мелатонина в дозах от 3000 мг до 6600 мг в течение нескольких недель наблюдались такие симптомы как гиперемия, спазмы в брюшной полости, диарея, головная боль, скотома. При применении очень высоких доз мелатонина (до 1 г) наблюдалась непроизвольная потеря сознания. При передозировке возможно развитие сонливости.\u003Cbr\u003EЛечение - промывание желудка и применение активированного угля, симптоматическая терапия. Клиренс активного вещества предполагается в пределах 12 часов после приема внутрь."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо воздержаться от управления транспортными средствами и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EВлияние различной степени почечной недостаточности на фармакокинетику мелатонина не изучено, поэтому таким пациентам мелатонин нужно применять с осторожностью.\u003Cbr\u003EВ период применения препарата Мелатонин Эвалар рекомендуется избегать пребывания на ярком свету.\u003Cbr\u003EНеобходимо проинформировать женщин, желающих забеременеть, о наличии у препарата слабого контрацептивного действия.\u003Cbr\u003EОтсутствуют клинические данные о применении мелатонина у больных с аутоиммунными заболеваниями, в связи с чем, применение у данной категории пациентов не рекомендуется. \u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих флувоксамин, который повышает концентрацию мелатонина за счет ингибирования его метаболизма изоферментами цитохрома Р450 (CYP): CYP1A2 и CYP2C19. Следует избегать такой комбинации.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих 5- и 8-метоксипсорален, который повышает концентрацию мелатонина вследствие ингибирования его метаболизма.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих циметидин, поскольку он повышает содержание мелатонина в плазме за счет ингибирования последнего.\u003Cbr\u003EКурение способно снизить концентрацию мелатонина за счет индукции изофермента CYP1A2.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих эстрогены (например, контрацептивы или заместительную гормональную терапию), которые увеличивают концентрацию мелатонина путем ингибирования их метаболизма изоферментами CYP1A1 и CYP1А2."},{"name":"Взаимодействие","value":"-Известно, что в концентрациях, значительно превышающих терапевтические, мелатонин индуцирует изофермент CYP3A in vitro. Клиническое значение этого явления до конца не выяснено. В случае развития признаков индукции следует рассмотреть вопрос о снижении дозы одновременно применяемых лекарственных средств.\u003Cbr\u003E- В концентрациях, значительно превышающих терапевтические, мелатонин не индуцирует изоферменты группы CYP1A in vitro. Следовательно, взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1А, по-видимому, незначимо.\u003Cbr\u003E- Метаболизм мелатонина, главным образом, опосредован изоферментами CYP1A. Следовательно, возможно взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1A.\u003Cbr\u003E- Ингибиторы изоферментов CYPA2, например, хинолоны, способны повышать экспозицию мелатонина.\u003Cbr\u003E- Индукторы изофермента CYP1A2, такие как карбамазепин и рифампицин, способны снижать плазменную концентрацию мелатонина.\u003Cbr\u003E- В современной литературе имеется множество данных, касающихся влияния агонистов/антагонистов адренергических и опиоидных рецепторов, антидепрессантов, ингибиторов простагландинов, бензодиазепинов, триптофана и алкоголя на секрецию эндогенного мелатонина. Исследования взаимного влияния этих препаратов на динамику или кинетику мелатонина не проводилось.\u003Cbr\u003EФармакодинамическое взаимодействие\u003Cbr\u003E- Во время приема мелатонина не следует употреблять алкоголь, так как он снижает эффективность препарата.\u003Cbr\u003E- Мелатонин потенцирует седативное действие бензодиазепиновых и небензодиазепиновых снотворных средств, таких как залеплон, золпидем и зопиклон. В ходе клинического исследования наблюдались четкие признаки транзиторного фармакодинамического взаимодействия между мелатонином и золпидемом спустя час после их приема. Комбинированное применение может приводить к прогрессирующему расстройству внимания, памяти и координации в сравнении с монотерапией золпидемом.\u003Cbr\u003E- В ходе исследований мелатонин назначался совместно с тиоридазином и имипрамином, препаратами, которые влияют на центральную нервную систему. Ни в одном из случаев не было выявлено клинически значимого фармакокинетического взаимодействия. Тем не менее, одновременное применение с мелатонином приводило к повышению ощущения спокойствия и к затруднениям в выполнении определенных заданий в сравнении с монотерапией имипрамином, а также к усилению чувства \"помутнения в голове\", в сравнении с монотерапией тиоридазином."},{"name":"Регистрационный номер","value":"ЛП-005295"},{"name":"Дата государственной регистрации","value":"14.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"Эвалар"},{"name":"Изготовитель","value":"Эвалар"},{"name":"Фасовщик","value":"Эвалар"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мелатонин Эвалар"},{"name":"Срок годности","value":"25 мес."}]}],"transitionId":"tr_10841397211662293304"}}}}
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Цена с картой Яндекс Пэй:400 ₽

Скидка: 2%
–2 %
Вместо: 408 ₽
  • 19 июня, курьер Маркета • 249 ₽
POLZAru
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  • Сонные+ таб., 30 шт., 1 уп.
    –33 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-q8ay6vkw7b/toggleWishlist":{"skuId":"101770175736","productId":265134488,"offerId":"wMgsDsk8DTmbDPDBVvo17Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYImMO2fhD4yeaP+wIYudaSBiDt2cEH","sign":"ObgN4YvUdFI9joIF2QEXjs8MUq+US5KbpX0JNL+JK9o="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-q8ay6vkw7b/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Сонные+ таб., 30 шт., 1 уп.

    Рейтинг товара: 4.1 из 5
    на основе 149 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 269 ₽ вместо 275
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-q8ay6vkw7b/addToCartButton":{"offerId":"wMgsDsk8DTmbDPDBVvo17Q","skuId":"101770175736","pendingCartItem":{"productId":265134488,"offerId":"wMgsDsk8DTmbDPDBVvo17Q","showPlaceId":"EpLBQl1u2TQuefeIEzEyjFzstXJGCezszT3QIz2QmqkBaBHhdhxwI7uKv6Yr5mE1APepKDKfCociTNswiMY2NcA9W-0A-U_tSpNXecygf0oy_QbvRQp0dt43sK2_Lvrj5hxoNoxgOrdY5XR8aD4md53U2M97fDyiJdzYRYk1gZjwxaJeUll5AyB_QD5vm1PAxxlU2YpI_DBPQdytssG54Pm6aX-AIwj8EUZg2XDZpAqLGfBPgmdHcnTb4HAL21x0","feeShow":"EpLBQl1u2TQuefeIEzEyjFzstXJGCezszT3QIz2QmqkBaBHhdhxwI7uKv6Yr5mE1APepKDKfCociTNswiMY2NcA9W-0A-U_tSpNXecygf0oy_QbvRQp0dt43sK2_Lvrj5hxoNoxgOrdY5XR8aD4md53U2M97fDyiJdzYRYk1gZjwxaJeUll5AyB_QD5vm1PAxxlU2YpI_DBPQdytssG54Pm6aX-AIwj8EUZg2XDZpAqLGfBPgmdHcnTb4HAL21x0","skuId":"101770175736","shopId":431782,"price":{"applicablePriceDiscounts":[{"priceWithDiscount":"269","type":"ya-card","totalPercentWithDiscount":33}],"discount":{"oldMin":"399","percent":31},"value":"275","currency":"RUR"},"hid":"15756525","name":"Сонные+ таб., 30 шт., 1 уп.","label":"p6zem1b0ken","count":0,"features":[],"imageMeta":{"namespace":"mpic","groupId":5274753,"key":"img_id6965893740203970582.jpeg"}},"quantity":{"step":1,"minimum":1,"maximum":999},"cpaUrl":"/safeclick/data=TxNGOK9vJEN7oLFLeCTKEkrTZoQadGRtjQLqzTxCAYEl31AulbEt2pVFWa6imKCCLcWYzeFXsf7X5Xg6iCXE4w8LXxgtwjlyU6A3PlLdu3smxgOlcqrGDLV3XjkPgX7we4vjWFo0nJzmlHPBMGZ3-auI-hC-czSmqsOfo_jpOJPONqg3-wqUF_TM6zY_dcaxvpfW6mKzwlvsdbDD3d864eP1Agn9lc8r6EmlcyPcAUiWGOXPXi4AAiVzgNsT4hYh9DjQLxPcHqx9638cJuTNXjJ7FGNQeAqCoM1gklO7IaFMTvNCZj201M7KlEmapw8vocHafvVMvavVgmHGKT2vpz3R3qKT2jevEYt7EYE3r0AbsM7xUnzNP7tOMvYea5vhoDwcFDQJf4smNOjC9m2_zAmiRSEybxmCuSVswIEnYQPebi1q-WLfExCFvMt--Zape2dFc3kNwDBnr3qveJWTX7PbOn6vmcdbgFNyp9HasX7O7UVi3I656sm0XFV626BaoUeWJhnB87SzXwrbvpAmQYVm2LZmRf4YyPIrOAr9XviujScpIh19dOdazba_wvgXr7fgkWjhobncKAZv4GVTtEMLe7gfrWe-d2TVdFAfGG7K41NJrZoHvnaHJg-gINQrTo-_2xUPmAt-ZExdBvdELFN7xxCJlSKuwffgFDURTru0K3UPh3wh4bInPZmhTpsdtkbqfzdeVrT0cbC-9MOF2Knm6Ts8ry0CNp_Xbk1yMVk5_ipgsUcTcWpnaXjPblBot-L4KytNREXOkuwTHsHODtRhgdMQf3l_oLpbTFKRhbP_F2dqboJUqY-ROLfJ9GuQImTJrbz7p_jl7nFoTzcWvSEXMVBWIGr5yxRNyAKAXQjvodU-ykDTr1SyAdlr7VkfcnwcjVhdpAVbL8eEKJLHe4z78RiS3eVbJ5hIioRZs3R0uU96uL_52qyUBOgtvYxiJXOk_cJ-ECU1xS1ChMsFJWpfdRwT0sG-3VMgt8TbmlstaHL6HO0y2LlY2n5omqDZofu5NRedhD8aHNEJJe3_18PDXM1EWc1X9zBfJzPdngzbFhJ2QFX6UZ2xUw9lsKkJnKY0rnx-BtvBcCszrwTc87Oxy5BZbbrLMstw5EMTHAYCrKBLYNKqiSxSDeW_ALLTkKTrBUbtAyffrLRqFK7ozizisTaOdYHTbW96weYmkco3MShXkSZFfiOFzFqcvGyWg4DaDiSewdshGJQB5t9LiEn1EnOGCIwsP-ryeQGLDg7SpYunD4jRCco-tcGHd7kDr9Dc_jTY8FK-ILOJIbXM1QiMMAgY5NsxJYMmIX8DNbPSJMDZWTKIYX_MNu57vUFPOclvhOwoS59X7rLaLXsBENF2tnTh3Gd9hMv0EMKvHAfGfoCruDK9JxjJemGrukCNBN4OXDXFhY4ZUmPIPyepbNfAGNg73IBf0b2LW_Jw0RenrFW9Ipgsisl3TjXSIqDfXfTXoCxxNY7mcmjFqzK0DNqrwx9knK85v1g6IctCQuuaNaMUVHOY8q37WeXUpaaxcA2INoPSQUBteOKZdOvWmFxrOUDZjWDDCUzAZotVKq-Y5ssG6rdv-DeCELNGJ5e9QxcbeY750GoE8pLKBazoulstRTf03q3yKjW8COnO_9jPAHGrBSGhUsq_fjVSHCDtLOkl29M8c4lzHo7TQS0IO3TXzRUytKesSV9TKNCa7qgZbiknXfW_glXnpKsHJvYc620Y9xqkToRcN10kmJ4Fkfmlt6RoECU7rOmCilJJd1mmT_W-drellQSnnSJbO94byL5P_xnFFptJ7qo8hyBfhAc6RGgTQplUXXicEmUFca58dKuhU_eMssJc_LusnXzIl8m5W7sRtXY4GKf-0RLRUY1al1YYWxrdrlsUJGxN7GILnJ6Vjbuhy8seaJ01GrH-Cwpj2QpwS7Tv5sIRFMhRLcfEUvThYvdmEfFyoW8tlOXHJtTg0Y7sNmaswpkGBpK7fQ0sl1LvhKNnSW79j7fjXcjqlOqJx2ttX7YTFUz3F-wAcRYSilAWOloa79oBPyWtV8FcJ-9s99Nuq1e9Seorss2h2V_e9gKMpHAfQsLTRznh7sSSUPw9Z9-b91PtOIUCkp0mCT7YNv3ChHY41KkYJ6s4fnB8T8aow-yGahm9qHVNPnWyXKN18oSL0XT3G2TGImdYhioMupfQdWxm48soQctMqjMRRhhMlebOgOP-pVEHSIxKOGZbbgmhgjV4TNRj0JHlvxPPe6cVu3IM-c-hTfdO3gHrrX8-kv6EIqdiAVIa8M10bEQrVjQxbBZLaIXKcxcXn-gtPhJTUPHKjA_j5jiNjgfppggTaaTM7Yh-EfsJ6yD8zdM8NJbm8q6p5X1Gnrf_taIhXLuxZ1mHyMEiSWhoO12MH34nAsa3zJOpUoJ-Emdk1-HbRdZSRpc7K8ONg5jfaUPtdzvCyK-FvRsFgoLfSh7Xl09_uixuzIj1brWVVMnlfwIDzifDf4xvlnNHS3lYuRGga0RFIbFzAamn9oA4_QQTk87YUMf0yXNOlilfEqK_pH6GzQZ99zUdGsHeP1TfaWZFcgPDyLWRWFuqvKF3vg_k5Yoyid4xb1uCRFyAOLwsm4t2hPXwgsdDIC0xsjQ5MPXbvRwe-TL34x4U2szgnVKHbpe1GBxdebbKXh27aU3fFNKdXafk_DBoA75tz0ZKEbkVfud9CmRWtZJmBpE_7DV1QBw1o1o-dPwBUGdKzHmblbTEpk_6VyhvkNs9rmDImR6C8AGlwE5qU94xVT2ebH_9R9Os6-_uvYw8RTysH46IpAG1JDtyGMSdrCev_dBo6173bzxGNBt0tM-TNmmx_Iw369PQgcQscz8rsghKbBX0m5fUuenYDbpSNyYLCHVfYLDP0watBDasyxqVeKwvr4vNrP1piLvZF23dQb6RVTlyPuxgPayMYxgUa1ztewnKjNE4NrEStWvauH8ihIK4jR8JyuZb-h3ARkAK3y3T8ZeBFUFVPTlQfAOr1QsEnA1VcXMBuuHnb1GleBCIfb4rGd_9Avm9YaEcmLUW7MAor2LKHG8pBOzIdcRTDawUk7PVZRFSOFcV7IrwiP7eTmH8jp59lx7YY3UjQ9b500-v_JbZBcgB8xHdow9po1g3e9ZH_NSw3gmIAIUNEBPUpQbwCck85XCQb5eC0amHe4LRqhvu0J_K1V6LMemMnG3MLRX0ZmXUU2jJfjawTsCKq-wEMyk78ufo0uzg4j7sF4VzL7FCmXBUh18iKXfPIhSbrx6kHLjUYo1jrgpGkAxaf4rYCv2dJM8JRIyz0tH5hKWhxLXepvESIehOZZhJvLmy25kfe8RnbAvSAotz25IEk4_uifNXJ1PJdXh4gHeLPUigjz8NObO6CleXPv2rTeeZPjWapjdp87kxY5oqfYV_i1yymVJ633SOJXjCnP1wg_6SJbXzCla-O8CCNi-DryEwfcAEVvnFPMhxk7mDLrjTVnXyrCWfIp5zRqE3TZ2Ze_2QwGOcX1HymUWKVGwqLYoOa4eVRaICwgF9_WCbUh3xDQ,,/b64e=1/sign=11305491acc11cbc26650dd0bd84dc61/keyno=MARKET_1/*","showUid":"17185449046336300275606002","cartLink":"/my/cart","showNotificationWhenDeleteItem":true,"isLavka":false,"isError":false,"isEats":false,"isCR":false,"isM2bEdoOnlyEnable":false,"isEatsMarketIntegration":true,"isCartButtonNext":false,"isUpsalePopupCRExp":false,"baobabClientDataAdditionToCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYImMO2fhD4yeaP+wIYudaSBiDt2cEH","sign":"ObgN4YvUdFI9joIF2QEXjs8MUq+US5KbpX0JNL+JK9o="},"target":"cart_addition"},"baobabClientDataDeletionFromCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYImMO2fhD4yeaP+wIYudaSBiDt2cEH","sign":"ObgN4YvUdFI9joIF2QEXjs8MUq+US5KbpX0JNL+JK9o="},"target":"cart_deletion"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-q8ay6vkw7b/addToCartButton":{"name":"@light/AddToCartButtonSnippet"}}}
  • Формула Спокойствия Триптофан капс., 15 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dum8x5qjwfr/toggleWishlist":{"skuId":"265175009","productId":1404748657,"offerId":"Rz_3euGCZiSuied3sBRffA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI8YbrnQUQ4f+4fhjVu6EGIO3ZwQc=","sign":"Jz4irTa6Ew8zeCQUiwT2dMiFKCywzNdWIXa6ISjfML4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-dum8x5qjwfr/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Формула Спокойствия Триптофан капс., 15 шт.

    Рейтинг товара: 4.6 из 5
    на основе 29 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 452 ₽ вместо 457
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  • Формула сна экспресс таб. д/рассас., 40 шт.
    –1 %
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    Формула сна экспресс таб. д/рассас., 40 шт.

    Рейтинг товара: 3.7 из 5
    на основе 3 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 483 ₽ вместо 488
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  • Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ii13fimaaun/toggleWishlist":{"skuId":"101967576139","productId":1823829062,"offerId":"3eS3wriM-RxhFnzr7m6jyQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIxtjV5QYQy/j27fsCGNW7oQYg7dnBBw==","sign":"//Gb1kLVyDeLsDmRyyOyfiHl8l9r86J2sQgOQkVWy6E="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ii13fimaaun/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 772 ₽ вместо 780
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  • Гинкго Билоба Эвалар таб., 0.5 г, 100 шт., 1 уп.
    –11 %
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    Гинкго Билоба Эвалар таб., 0.5 г, 100 шт., 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 339 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 296 ₽ вместо 1 309
    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Билоба Эвалар таб., 0.5 г, 100 шт., 1 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  • Формула сна усиленная фито-мелатонином капс., 30 шт.
    –1 %
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    Формула сна усиленная фито-мелатонином капс., 30 шт.

    Рейтинг товара: 4 из 5
    на основе 11 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 613 ₽ вместо 619
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  • GLS Триптофан капс., 500 мг, 0.25 г, 90 шт.
    –10 %
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    GLS Триптофан капс., 500 мг, 0.25 г, 90 шт.

    Рейтинг товара: 4.8 из 5
    на основе 24 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 540 ₽ вместо 550
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Триптофан капс., 500 мг, 0.25 г, 90 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  • Good Sleep спрей фл., 30 мл, 10 г, 1 шт., мятный, 1 уп.
    –34 %
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    Good Sleep спрей фл., 30 мл, 10 г, 1 шт., мятный, 1 уп.

    Рейтинг товара: 4.6 из 5
    на основе 223 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 185 ₽ вместо 1 209
    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  • Формула сна таб., 40 шт., 1 уп.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fmacsjcgrji/toggleWishlist":{"skuId":"101826746755","productId":265154706,"offerId":"6iMLtFvWYt_I5w6OMptjCQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIkuG3fhCDs+Oq+wIY1buhBiDt2cEH","sign":"OtPdUcAIEdOPxRlY6rQtdA0NmlLHaG2xuBaF71f03eE="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fmacsjcgrji/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Формула сна таб., 40 шт., 1 уп.

    Рейтинг товара: 4.2 из 5
    на основе 21 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 409 ₽ вместо 413
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fmacsjcgrji/addToCartButton":{"offerId":"6iMLtFvWYt_I5w6OMptjCQ","skuId":"101826746755","pendingCartItem":{"productId":265154706,"offerId":"6iMLtFvWYt_I5w6OMptjCQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMoD5uVlEiKa1-dfj8pPxl1qgOwQxzXeOfXVIbEXYP0XYf1s_HwsGF6-DbQr6uGaLorLAT-ETSwoLYBTjRyq-EoLKnZ7wmGAvMKtoOGicddjKZJCJ4fgLgu89fUBz6_UIIZZepozcW30IL5cs4ioMdLU52jC93v77aKDpHP7pZy7kpKphn6RZJK_ZB8tDk-EA6A,,","feeShow":"OTNDnItfwRMjN9MRHuEMMoD5uVlEiKa1-dfj8pPxl1qgOwQxzXeOfXVIbEXYP0XYf1s_HwsGF6-DbQr6uGaLorLAT-ETSwoLYBTjRyq-EoLKnZ7wmGAvMKtoOGicddjKZJCJ4fgLgu89fUBz6_UIIZZepozcW30IL5cs4ioMdLU52jC93v77aKDpHP7pZy7kpKphn6RZJK_ZB8tDk-EA6A,,","skuId":"101826746755","shopId":431782,"price":{"applicablePriceDiscounts":[{"priceWithDiscount":"409","type":"ya-card","totalPercentWithDiscount":1}],"value":"413","currency":"RUR"},"hid":"15756525","name":"Формула сна таб., 40 шт., 1 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  • Релаксозан День таб., 40 шт.
    –2 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cfq1bxo40t/toggleWishlist":{"skuId":"662913030","productId":1404748725,"offerId":"vlofFuboBG9cplvDff8e6w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYItYfrnQUQhoCNvAIY1buhBiDt2cEH","sign":"K4dqP0epooMcTK5BcTFFKYkInlduoVK7GbY0UFV/8Tg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-cfq1bxo40t/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Релаксозан День таб., 40 шт.

    Рейтинг товара: 4.7 из 5
    на основе 124 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 669 ₽ вместо 683
    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День таб., 40 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  • Natrol Melatonin таб., 3 мг, 100 г, 60 шт.
    –28 %
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    Natrol Melatonin таб., 3 мг, 100 г, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 558 ₽ вместо 1 590
    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Melatonin таб., 3 мг, 100 г, 60 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Инструкция

Показания к применению

При расстройствах сна, в т.ч. обусловленных нарушением ритма "сон-бодрствование", таких как десинхроноз (резкая смена часовых поясов).

Противопоказания

Гиперчувствительность к компонентам препарата, аутоиммунные заболевания, печеночная недостаточность, тяжелая почечная недостаточность, детский возраст до 18 лет, беременность, период грудного вскармливания.

Способ применения и дозы

Внутрь.
При нарушении сна - по 3 мг один раз в сутки за 30-40 минут до сна.
При десинхронозе в качестве адаптогена при смене часовых поясов - за 1 день до перелета и в последующие 2-5 дней - по 3 мг за 30-40 минут до сна.
Максимальная суточная доза - 6 мг.
Пожилые пациенты
С возрастом происходит снижение метаболизма мелатонина, что необходимо учитывать при выборе режима дозирования для пожилых пациентов. С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.
Пациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется.
Полная инструкция
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Мелатонин Эвалар таб. п/о плен.
Мелатонин Эвалар таб. п/о плен., 3 мг, 20 шт., 1 уп.
4.6
(97)
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13 вопросов
Инструкция

Цена с картой Яндекс Пэй:400 ₽

Скидка: 2%
–2 %
Вместо: 408 ₽
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4.6
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У продавца:97 оценок·25 отзывов
У всех продавцов:710 оценок·295 отзывов
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user avatar
4 месяца назад • Andry Goryachev • Куплен на Маркете
Комментарий: Пользую около года-возраст даёт себя знать. Метода употребления-отбой 21-00,таблетку рассосать за 20 минут до желаемого времени засыпания. Нормальный сон до 7....8 утра. Помогает в 80% случаев.
user avatar
10 месяцев назад • Ольга Т. • Куплен на Маркете
Комментарий: Супер вещь! Выпиваешь и после 30-40 минут обязательно нужно лечь спать, или хотя бы просто полежать закрытыми глазами если не спится, уснëте в любом случае, если соблюдать это правило, тогда действует очень эффективно. Спишь до утра сладким сном и при этом утром чувствуешь себя бодро, наполненным энергией и силами.
user avatar
2 месяца назад • katurs • Куплен на Маркете
Достоинства: Лёгкий снотворный эффект. Препарат не вызывает привыкания. Отпускается без рецепта.
Недостатки: Очевидных не нашел.
Комментарий: Надеюсь и дальше смогу пользоваться при необходимости.
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    Цена 452 ₽ вместо 457
  • Глицин Форте Эвалар таб. д/расс., 500 мг, 60 шт.
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    Глицин Форте Эвалар таб. д/расс., 500 мг, 60 шт.

    Цена 487 ₽ вместо 610
  • Уголь активированный таб., 250 мг, 50 шт.
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    Уголь активированный таб., 250 мг, 50 шт.

    Цена 50 ₽
  • Гармония сна капс., 0.36 г
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:668070085_3/content/content/toggleWishlist":{"skuId":"101769018728","productId":668070085,"offerId":"mrKeEQUdw6wLJV5wkePTrQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCMXhx74CEOj6n4/7Ahigu/YFIO3ZwQc=","sign":"XrsB91GyLDGlw1ImScgmzUNwlL82VraR2SKSC962ILg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:668070085_3/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гармония сна капс., 0.36 г

    Цена 311 ₽ вместо 742
  • Магний В6 таб., 1.25 г, 30 шт.
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    Магний В6 таб., 1.25 г, 30 шт.

    Цена 454 ₽ вместо 464
  • Формула сна экспресс таб. д/рассас., 40 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778173019_5/content/content/toggleWishlist":{"skuId":"641533148","productId":1778173019,"offerId":"gDF6ysrOQpJ4tTa5OA8_cw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCNuI888GENyJ9LECGNW7oQYg7dnBBw==","sign":"P0JYCHdTWayAiA4Bp3WqPzGj/IFdfgtKjJLxnSALafk="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778173019_5/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Формула сна экспресс таб. д/рассас., 40 шт.

    Цена 483 ₽ вместо 488
  • Витамин Д3 + К2 таб. жев., 1200 МЕ, 0.22 г, 60 шт.
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    Витамин Д3 + К2 таб. жев., 1200 МЕ, 0.22 г, 60 шт.

    Цена 408 ₽ вместо 412
  • Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.
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    Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.

    Цена 772 ₽ вместо 780
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    Реклама
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  • Сонные+ таб., 30 шт., 1 уп.
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    Сонные+ таб., 30 шт., 1 уп.

    Цена 269 ₽ вместо 399
  • Магний хелат таб., 1.4 г, 120 шт.
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    Магний хелат таб., 1.4 г, 120 шт.

    Цена 1 465 ₽ вместо 1 892
  • Формула сна усиленная фито-мелатонином капс., 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172926_11/content/content/gallery":{"title":"Формула сна усиленная фито-мелатонином капс., 30 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id3889967145932192887.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5150634/img_id8335402938133673091.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5219059/img_id2403905036614165736.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCP6H888GEJPFtn4Y1buhBiDt2cEH","sign":"w/HZZXFCTsZmuaD4zLTLtz/HEwKP4OPoZhVSEruFT1I="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172926_11/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Формула сна усиленная фито-мелатонином капс., 30 шт.

    Цена 613 ₽ вместо 619
  • Формула сна таб., 40 шт., 1 уп.
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    Формула сна таб., 40 шт., 1 уп.

    Цена 409 ₽ вместо 413
  • GLS Триптофан капс., 500 мг, 0.25 г, 90 шт.
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    GLS Триптофан капс., 500 мг, 0.25 г, 90 шт.

    Цена 540 ₽ вместо 600
  • Эвалар Витамин Д3 максимум 2000 МЕ 120 капсул
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    Эвалар Витамин Д3 максимум 2000 МЕ 120 капсул

    Цена 531 ₽ вместо 596
  • Панкреатин таб. п/о кш/раств. (блистеры), 25 ЕД, 20 шт.
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    Панкреатин таб. п/о кш/раств. (блистеры), 25 ЕД, 20 шт.

    Цена 35 ₽
  • Эвалар Таурин 1000 мг 60 таблеток
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    Эвалар Таурин 1000 мг 60 таблеток

    Цена 621 ₽ вместо 660
  • Панангин таб. п/о плен., 50 шт.
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    Панангин таб. п/о плен., 50 шт.

    Цена 183 ₽ вместо 185
  • Цинк хелат таб. п/о плен., 25 мг, 200 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:662907025_18/content/content/toggleWishlist":{"skuId":"101870504751","productId":662907025,"offerId":"hYRqPnuFL3Rgy6N3hNaqLQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQiIzBruf8o+sTEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCJHRjLwCEK+W0r/7AhjVu6EGIJnDBQ==","sign":"23cJWE/HNyLDgnmZt2Y4QttnkvZ16a0PgYFy+sxR9T4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:662907025_18/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Цинк хелат таб. п/о плен., 25 мг, 200 шт.

    Цена 703 ₽ вместо 865
  • Эвалар Тройная Омега-3 950 мг 120 капсул
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    Эвалар Тройная Омега-3 950 мг 120 капсул

    Цена 2 584 ₽ вместо 3 292
  • Гинкго Билоба Эвалар таб., 0.5 г, 40 шт., 1 уп.
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    Гинкго Билоба Эвалар таб., 0.5 г, 40 шт., 1 уп.

    Цена 428 ₽ вместо 432
  • Хлоргексидина биглюконат р-р д/мест. и нар. прим. фл., 0,05%, 100 мл
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    Хлоргексидина биглюконат р-р д/мест. и нар. прим. фл., 0,05%, 100 мл

    Цена 17 ₽
  • Дигидрокверцетин таб., 25 мг, 20 шт.
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    Дигидрокверцетин таб., 25 мг, 20 шт.

    Цена 289 ₽ вместо 292
  • Релаксозан День таб., 20 шт.
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    Релаксозан День таб., 20 шт.

    Цена 488 ₽ вместо 493
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