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Мелатонин Эвалар таб. п/о плен., 3 мг, 40 шт., 1 уп.

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4.6
(97)
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Количество штук в упаковке, шт.: 40

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Коротко о товаре

Артикул Маркета
3288462223
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"8832884429629011236":{"specItems":[{"name":"Артикул Маркета","value":"3288462223","withCopyValueButton":true},{"name":"тип препарата","value":"лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"десинхроноз, нарушение сна","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["36476390:36618389,36618157"]}}},{"name":"действующее вещество","value":"Мелатонин","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28708746"]}}},{"name":"возраст","value":"от 18 лет"},{"name":"форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"8832884429629011236":{"specItems":[{"name":"Артикул Маркета","value":"3288462223","withCopyValueButton":true},{"name":"Тип препарата","value":"Лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Назначение","value":"Десинхроноз, нарушение сна","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["36476390:36618389,36618157"]}}},{"name":"Действующее вещество","value":"Мелатонин","transition":{"type":"list","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28708746"]}}},{"name":"Возраст","value":"От 18 лет"}]}},"fullSpecs":{"8832884429629011236":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313"]}}},{"name":"Органы и системы","value":"головной мозг, нервная система"},{"name":"Назначение","value":"десинхроноз, нарушение сна","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["36476390:36618389,36618157"]}}},{"name":"Показания к применению","value":"При расстройствах сна, в т.ч. обусловленных нарушением ритма \"сон-бодрствование\", таких как десинхроноз (резкая смена часовых поясов)."},{"name":"Противопоказания","value":"Гиперчувствительность к компонентам препарата, аутоиммунные заболевания, печеночная недостаточность, тяжелая почечная недостаточность, детский возраст до 18 лет, беременность, период грудного вскармливания."},{"name":"Состав","value":"На одну таблетку:\u003Cbr\u003EДействующее вещество: мелатонин - 3,00 мг.\u003Cbr\u003EВспомогательные вещества: целлюлоза микрокристаллическая - 172,72 мг, кальция гидрофосфат - 54,68 мг, кроскармеллоза натрия - 7,20 мг, кремния диоксид коллоидный - 1,20 мг, магния стеарат - 1,20 мг.\u003Cbr\u003EВспомогательные вещества оболочки: гипромеллоза (гидроксипропилметилцеллюлоза) - 4,00 мг, титана диоксид - 2,90 мг, полисорбат 80 - 1,32 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,89 мг, тальк - 0,89 мг."},{"name":"Действующее вещество","value":"Мелатонин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28708746"]}}},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr\u003EПри нарушении сна - по 3 мг один раз в сутки за 30-40 минут до сна.\u003Cbr\u003EПри десинхронозе в качестве адаптогена при смене часовых поясов - за 1 день до перелета и в последующие 2-5 дней - по 3 мг за 30-40 минут до сна.\u003Cbr\u003EМаксимальная суточная доза - 6 мг.\u003Cbr\u003EПожилые пациенты\u003Cbr\u003EС возрастом происходит снижение метаболизма мелатонина, что необходимо учитывать при выборе режима дозирования для пожилых пациентов. С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.\u003Cbr\u003EПациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется."},{"name":"Побочные действия","value":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной Организации Здравоохранения:\u003Cbr\u003EОчень часто (≥1/10), часто (от ≥1/10 до \u003C1/10), нечасто (от ≥1/1000 до \u003C1/100), редко (от ≥1/10000 до \u003C1/1000), очень редко (\u003C1/10000), включая отдельные сообщения; частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможном).\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eредко: опоясывающий герпес.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003Eредко: лейкопения, тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eчастота неизвестна: реакции гиперчувствительности.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eредко: гипертриглицеридемия, гипокалиемия, гипонатриемия.\u003Cbr\u003EНарушение психики:\u003Cbr\u003Eнечасто: раздражительность, нервозность, беспокойство, бессонница, необычные сновидения, ночные кошмары, тревога;\u003Cbr\u003Eредко: перемены настроения, агрессия, ажитация, плаксивость, симптомы стресса, дезориентация, раннее утреннее пробуждение, повышение либидо, сниженное настроение, депрессия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто: мигрень, головная боль, вялость, психомоторная гиперактивность, головокружение, сонливость;\u003Cbr\u003Eредко: обморок, нарушение памяти, нарушение концентрации внимания, делирий, синдром \"беспокойных ног\", сновидное состояние, плохое качество сна, парестезии.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eредко: снижение остроты зрения, нечеткость зрения, повышенное слезотечение.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения:\u003Cbr\u003Eредко: вертиго, позиционное вертиго.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы:\u003Cbr\u003Eнечасто: артериальная гипертензия;\u003Cbr\u003Eредко: стенокардия напряжения, ощущение сердцебиения, приливы.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто: абдоминальная боль, абдоминальная боль в верхней части живота, диспепсия, язвенный стоматит, сухость во рту, тошнота;\u003Cbr\u003Eредко: гастроэзофагеальная болезнь, желудочно-кишечное нарушение или расстройство, буллезный стоматит, язвенный глоссит, рвота, усиление перистальтики, вздутие живота, гиперсекреция слюны, неприятный запах изо рта, абдоминальный дискомфорт, дискинезия желудка, гастрит.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003Eнечасто: гипербилирубинемия.\u003Cbr\u003EНарушение со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто: дерматит, потливость по ночам, зуд и генерализованный зуд, сыпь, сухость кожи;\u003Cbr\u003Eредко: экзема, эритема, дерматит рук, псориаз, генерализованная сыпь, зудящая сыпь, поражение ногтей;\u003Cbr\u003Eчастота неизвестна: отек Квинке, отек слизистой оболочки полости рта, отек языка.\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr\u003Eнечасто: боль в конечностях.\u003Cbr\u003Eредко: артрит, мышечный спазм, боль в шее, ночные судороги.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eнечасто: глюкозурия, протеинурия;\u003Cbr\u003Eредко: полиурия, гематурия, никтурия.\u003Cbr\u003EНарушения со стороны половых органов и грудной железы:\u003Cbr\u003Eнечасто: менопаузальные симптомы;\u003Cbr\u003Eредко: приапизм, простатит; частота неизвестна: галакторея.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто: астения, боль в груди;\u003Cbr\u003Eредко: утомляемость, боль, жажда.\u003Cbr\u003EЛабораторные и инструментальные данные:\u003Cbr\u003Eнечасто: отклонение от нормы лабораторных показателей функции печени, увеличение массы тела;\u003Cbr\u003Eредко: повышение активности \"печеночных\" трансаминаз, отклонение от нормы содержания электролитов в крови, отклонение от нормы результатов лабораторных тестов."},{"name":"Фармакологическое действие","value":"Мелатонин - синтетический аналог гормона шишковидного тела (эпифиза); синтезирован из аминокислот растительного происхождения.\u003Cbr\u003EОказывает адаптогенное, седативное, снотворное действие. Нормализует циркадные ритмы.\u003Cbr\u003EУвеличивает концентрацию гамма-аминомасляной кислоты (ГАМК) и серотонина в среднем мозге и гипоталамусе, изменяет активность пиридоксалькиназы, участвующей в синтезе ГАМК, дофамина и серотонина.\u003Cbr\u003EРегулирует цикл сон-бодрствование, суточные изменения локомоторной активности и температуры тела, положительно влияет на интеллектуально-мнестические функции мозга, на эмоционально-личностную сферу. Способствует организации биологического ритма и нормализации ночного сна, обладает снотворным эффектом. Улучшает качество сна, ускоряет засыпание, снижает число ночных пробуждений, улучшает самочувствие после утреннего пробуждения, не вызывает ощущение вялости, разбитости и усталости при пробуждении. Делает сновидения более яркими и эмоционально насыщенными.\u003Cbr\u003EАдаптирует организм к быстрой смене часовых поясов, снижает стрессовые реакции, регулирует нейроэндокринные функции.\u003Cbr\u003EАдаптирует организм метеочувствительных людей к изменениям погодных условий.\u003Cbr\u003EПроявляет иммуностимулирующие и антиоксидантные свойства.\u003Cbr\u003EНе вызывает привыкания и зависимости."},{"name":"Фармакологическая группа","value":"адаптогенное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С, в оригинальной упаковке.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"По имеющимся литературным данным, применение мелатонина в суточной дозировке до 300 мг не вызывало клинически значимых нежелательных реакций. При приеме мелатонина в дозах от 3000 мг до 6600 мг в течение нескольких недель наблюдались такие симптомы как гиперемия, спазмы в брюшной полости, диарея, головная боль, скотома. При применении очень высоких доз мелатонина (до 1 г) наблюдалась непроизвольная потеря сознания. При передозировке возможно развитие сонливости.\u003Cbr\u003EЛечение - промывание желудка и применение активированного угля, симптоматическая терапия. Клиренс активного вещества предполагается в пределах 12 часов после приема внутрь."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо воздержаться от управления транспортными средствами и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EВлияние различной степени почечной недостаточности на фармакокинетику мелатонина не изучено, поэтому таким пациентам мелатонин нужно применять с осторожностью.\u003Cbr\u003EВ период применения препарата Мелатонин Эвалар рекомендуется избегать пребывания на ярком свету.\u003Cbr\u003EНеобходимо проинформировать женщин, желающих забеременеть, о наличии у препарата слабого контрацептивного действия.\u003Cbr\u003EОтсутствуют клинические данные о применении мелатонина у больных с аутоиммунными заболеваниями, в связи с чем, применение у данной категории пациентов не рекомендуется. \u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих флувоксамин, который повышает концентрацию мелатонина за счет ингибирования его метаболизма изоферментами цитохрома Р450 (CYP): CYP1A2 и CYP2C19. Следует избегать такой комбинации.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих 5- и 8-метоксипсорален, который повышает концентрацию мелатонина вследствие ингибирования его метаболизма.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих циметидин, поскольку он повышает содержание мелатонина в плазме за счет ингибирования последнего.\u003Cbr\u003EКурение способно снизить концентрацию мелатонина за счет индукции изофермента CYP1A2.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих эстрогены (например, контрацептивы или заместительную гормональную терапию), которые увеличивают концентрацию мелатонина путем ингибирования их метаболизма изоферментами CYP1A1 и CYP1А2."},{"name":"Взаимодействие","value":"-Известно, что в концентрациях, значительно превышающих терапевтические, мелатонин индуцирует изофермент CYP3A in vitro. Клиническое значение этого явления до конца не выяснено. В случае развития признаков индукции следует рассмотреть вопрос о снижении дозы одновременно применяемых лекарственных средств.\u003Cbr\u003E- В концентрациях, значительно превышающих терапевтические, мелатонин не индуцирует изоферменты группы CYP1A in vitro. Следовательно, взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1А, по-видимому, незначимо.\u003Cbr\u003E- Метаболизм мелатонина, главным образом, опосредован изоферментами CYP1A. Следовательно, возможно взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1A.\u003Cbr\u003E- Ингибиторы изоферментов CYPA2, например, хинолоны, способны повышать экспозицию мелатонина.\u003Cbr\u003E- Индукторы изофермента CYP1A2, такие как карбамазепин и рифампицин, способны снижать плазменную концентрацию мелатонина.\u003Cbr\u003E- В современной литературе имеется множество данных, касающихся влияния агонистов/антагонистов адренергических и опиоидных рецепторов, антидепрессантов, ингибиторов простагландинов, бензодиазепинов, триптофана и алкоголя на секрецию эндогенного мелатонина. Исследования взаимного влияния этих препаратов на динамику или кинетику мелатонина не проводилось.\u003Cbr\u003EФармакодинамическое взаимодействие\u003Cbr\u003E- Во время приема мелатонина не следует употреблять алкоголь, так как он снижает эффективность препарата.\u003Cbr\u003E- Мелатонин потенцирует седативное действие бензодиазепиновых и небензодиазепиновых снотворных средств, таких как залеплон, золпидем и зопиклон. В ходе клинического исследования наблюдались четкие признаки транзиторного фармакодинамического взаимодействия между мелатонином и золпидемом спустя час после их приема. Комбинированное применение может приводить к прогрессирующему расстройству внимания, памяти и координации в сравнении с монотерапией золпидемом.\u003Cbr\u003E- В ходе исследований мелатонин назначался совместно с тиоридазином и имипрамином, препаратами, которые влияют на центральную нервную систему. Ни в одном из случаев не было выявлено клинически значимого фармакокинетического взаимодействия. Тем не менее, одновременное применение с мелатонином приводило к повышению ощущения спокойствия и к затруднениям в выполнении определенных заданий в сравнении с монотерапией имипрамином, а также к усилению чувства \"помутнения в голове\", в сравнении с монотерапией тиоридазином."},{"name":"Регистрационный номер","value":"ЛП-005295"},{"name":"Дата государственной регистрации","value":"14.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"Эвалар","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:13131221"]}}},{"name":"Изготовитель","value":"Эвалар"},{"name":"Фасовщик","value":"Эвалар"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мелатонин Эвалар","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:26106970"]}}},{"name":"Срок годности","value":"25 мес."}]}},"fullSpecsGrouped":{"8832884429629011236":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"головной мозг, нервная система"},{"name":"Назначение","value":"десинхроноз, нарушение сна"},{"name":"Показания к применению","value":"При расстройствах сна, в т.ч. обусловленных нарушением ритма \"сон-бодрствование\", таких как десинхроноз (резкая смена часовых поясов)."},{"name":"Противопоказания","value":"Гиперчувствительность к компонентам препарата, аутоиммунные заболевания, печеночная недостаточность, тяжелая почечная недостаточность, детский возраст до 18 лет, беременность, период грудного вскармливания."},{"name":"Состав","value":"На одну таблетку:\u003Cbr\u003EДействующее вещество: мелатонин - 3,00 мг.\u003Cbr\u003EВспомогательные вещества: целлюлоза микрокристаллическая - 172,72 мг, кальция гидрофосфат - 54,68 мг, кроскармеллоза натрия - 7,20 мг, кремния диоксид коллоидный - 1,20 мг, магния стеарат - 1,20 мг.\u003Cbr\u003EВспомогательные вещества оболочки: гипромеллоза (гидроксипропилметилцеллюлоза) - 4,00 мг, титана диоксид - 2,90 мг, полисорбат 80 - 1,32 мг, макрогол 4000 (полиэтиленгликоль 4000) - 0,89 мг, тальк - 0,89 мг."},{"name":"Действующее вещество","value":"Мелатонин"},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr\u003EПри нарушении сна - по 3 мг один раз в сутки за 30-40 минут до сна.\u003Cbr\u003EПри десинхронозе в качестве адаптогена при смене часовых поясов - за 1 день до перелета и в последующие 2-5 дней - по 3 мг за 30-40 минут до сна.\u003Cbr\u003EМаксимальная суточная доза - 6 мг.\u003Cbr\u003EПожилые пациенты\u003Cbr\u003EС возрастом происходит снижение метаболизма мелатонина, что необходимо учитывать при выборе режима дозирования для пожилых пациентов. С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.\u003Cbr\u003EПациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется."},{"name":"Побочные действия","value":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной Организации Здравоохранения:\u003Cbr\u003EОчень часто (≥1/10), часто (от ≥1/10 до \u003C1/10), нечасто (от ≥1/1000 до \u003C1/100), редко (от ≥1/10000 до \u003C1/1000), очень редко (\u003C1/10000), включая отдельные сообщения; частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможном).\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eредко: опоясывающий герпес.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003Eредко: лейкопения, тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eчастота неизвестна: реакции гиперчувствительности.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eредко: гипертриглицеридемия, гипокалиемия, гипонатриемия.\u003Cbr\u003EНарушение психики:\u003Cbr\u003Eнечасто: раздражительность, нервозность, беспокойство, бессонница, необычные сновидения, ночные кошмары, тревога;\u003Cbr\u003Eредко: перемены настроения, агрессия, ажитация, плаксивость, симптомы стресса, дезориентация, раннее утреннее пробуждение, повышение либидо, сниженное настроение, депрессия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто: мигрень, головная боль, вялость, психомоторная гиперактивность, головокружение, сонливость;\u003Cbr\u003Eредко: обморок, нарушение памяти, нарушение концентрации внимания, делирий, синдром \"беспокойных ног\", сновидное состояние, плохое качество сна, парестезии.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eредко: снижение остроты зрения, нечеткость зрения, повышенное слезотечение.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения:\u003Cbr\u003Eредко: вертиго, позиционное вертиго.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы:\u003Cbr\u003Eнечасто: артериальная гипертензия;\u003Cbr\u003Eредко: стенокардия напряжения, ощущение сердцебиения, приливы.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто: абдоминальная боль, абдоминальная боль в верхней части живота, диспепсия, язвенный стоматит, сухость во рту, тошнота;\u003Cbr\u003Eредко: гастроэзофагеальная болезнь, желудочно-кишечное нарушение или расстройство, буллезный стоматит, язвенный глоссит, рвота, усиление перистальтики, вздутие живота, гиперсекреция слюны, неприятный запах изо рта, абдоминальный дискомфорт, дискинезия желудка, гастрит.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003Eнечасто: гипербилирубинемия.\u003Cbr\u003EНарушение со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто: дерматит, потливость по ночам, зуд и генерализованный зуд, сыпь, сухость кожи;\u003Cbr\u003Eредко: экзема, эритема, дерматит рук, псориаз, генерализованная сыпь, зудящая сыпь, поражение ногтей;\u003Cbr\u003Eчастота неизвестна: отек Квинке, отек слизистой оболочки полости рта, отек языка.\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr\u003Eнечасто: боль в конечностях.\u003Cbr\u003Eредко: артрит, мышечный спазм, боль в шее, ночные судороги.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eнечасто: глюкозурия, протеинурия;\u003Cbr\u003Eредко: полиурия, гематурия, никтурия.\u003Cbr\u003EНарушения со стороны половых органов и грудной железы:\u003Cbr\u003Eнечасто: менопаузальные симптомы;\u003Cbr\u003Eредко: приапизм, простатит; частота неизвестна: галакторея.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто: астения, боль в груди;\u003Cbr\u003Eредко: утомляемость, боль, жажда.\u003Cbr\u003EЛабораторные и инструментальные данные:\u003Cbr\u003Eнечасто: отклонение от нормы лабораторных показателей функции печени, увеличение массы тела;\u003Cbr\u003Eредко: повышение активности \"печеночных\" трансаминаз, отклонение от нормы содержания электролитов в крови, отклонение от нормы результатов лабораторных тестов."},{"name":"Фармакологическое действие","value":"Мелатонин - синтетический аналог гормона шишковидного тела (эпифиза); синтезирован из аминокислот растительного происхождения.\u003Cbr\u003EОказывает адаптогенное, седативное, снотворное действие. Нормализует циркадные ритмы.\u003Cbr\u003EУвеличивает концентрацию гамма-аминомасляной кислоты (ГАМК) и серотонина в среднем мозге и гипоталамусе, изменяет активность пиридоксалькиназы, участвующей в синтезе ГАМК, дофамина и серотонина.\u003Cbr\u003EРегулирует цикл сон-бодрствование, суточные изменения локомоторной активности и температуры тела, положительно влияет на интеллектуально-мнестические функции мозга, на эмоционально-личностную сферу. Способствует организации биологического ритма и нормализации ночного сна, обладает снотворным эффектом. Улучшает качество сна, ускоряет засыпание, снижает число ночных пробуждений, улучшает самочувствие после утреннего пробуждения, не вызывает ощущение вялости, разбитости и усталости при пробуждении. Делает сновидения более яркими и эмоционально насыщенными.\u003Cbr\u003EАдаптирует организм к быстрой смене часовых поясов, снижает стрессовые реакции, регулирует нейроэндокринные функции.\u003Cbr\u003EАдаптирует организм метеочувствительных людей к изменениям погодных условий.\u003Cbr\u003EПроявляет иммуностимулирующие и антиоксидантные свойства.\u003Cbr\u003EНе вызывает привыкания и зависимости."},{"name":"Фармакологическая группа","value":"адаптогенное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С, в оригинальной упаковке.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"По имеющимся литературным данным, применение мелатонина в суточной дозировке до 300 мг не вызывало клинически значимых нежелательных реакций. При приеме мелатонина в дозах от 3000 мг до 6600 мг в течение нескольких недель наблюдались такие симптомы как гиперемия, спазмы в брюшной полости, диарея, головная боль, скотома. При применении очень высоких доз мелатонина (до 1 г) наблюдалась непроизвольная потеря сознания. При передозировке возможно развитие сонливости.\u003Cbr\u003EЛечение - промывание желудка и применение активированного угля, симптоматическая терапия. Клиренс активного вещества предполагается в пределах 12 часов после приема внутрь."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо воздержаться от управления транспортными средствами и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EВлияние различной степени почечной недостаточности на фармакокинетику мелатонина не изучено, поэтому таким пациентам мелатонин нужно применять с осторожностью.\u003Cbr\u003EВ период применения препарата Мелатонин Эвалар рекомендуется избегать пребывания на ярком свету.\u003Cbr\u003EНеобходимо проинформировать женщин, желающих забеременеть, о наличии у препарата слабого контрацептивного действия.\u003Cbr\u003EОтсутствуют клинические данные о применении мелатонина у больных с аутоиммунными заболеваниями, в связи с чем, применение у данной категории пациентов не рекомендуется. \u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих флувоксамин, который повышает концентрацию мелатонина за счет ингибирования его метаболизма изоферментами цитохрома Р450 (CYP): CYP1A2 и CYP2C19. Следует избегать такой комбинации.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих 5- и 8-метоксипсорален, который повышает концентрацию мелатонина вследствие ингибирования его метаболизма.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих циметидин, поскольку он повышает содержание мелатонина в плазме за счет ингибирования последнего.\u003Cbr\u003EКурение способно снизить концентрацию мелатонина за счет индукции изофермента CYP1A2.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих эстрогены (например, контрацептивы или заместительную гормональную терапию), которые увеличивают концентрацию мелатонина путем ингибирования их метаболизма изоферментами CYP1A1 и CYP1А2."},{"name":"Взаимодействие","value":"-Известно, что в концентрациях, значительно превышающих терапевтические, мелатонин индуцирует изофермент CYP3A in vitro. Клиническое значение этого явления до конца не выяснено. В случае развития признаков индукции следует рассмотреть вопрос о снижении дозы одновременно применяемых лекарственных средств.\u003Cbr\u003E- В концентрациях, значительно превышающих терапевтические, мелатонин не индуцирует изоферменты группы CYP1A in vitro. Следовательно, взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1А, по-видимому, незначимо.\u003Cbr\u003E- Метаболизм мелатонина, главным образом, опосредован изоферментами CYP1A. Следовательно, возможно взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1A.\u003Cbr\u003E- Ингибиторы изоферментов CYPA2, например, хинолоны, способны повышать экспозицию мелатонина.\u003Cbr\u003E- Индукторы изофермента CYP1A2, такие как карбамазепин и рифампицин, способны снижать плазменную концентрацию мелатонина.\u003Cbr\u003E- В современной литературе имеется множество данных, касающихся влияния агонистов/антагонистов адренергических и опиоидных рецепторов, антидепрессантов, ингибиторов простагландинов, бензодиазепинов, триптофана и алкоголя на секрецию эндогенного мелатонина. Исследования взаимного влияния этих препаратов на динамику или кинетику мелатонина не проводилось.\u003Cbr\u003EФармакодинамическое взаимодействие\u003Cbr\u003E- Во время приема мелатонина не следует употреблять алкоголь, так как он снижает эффективность препарата.\u003Cbr\u003E- Мелатонин потенцирует седативное действие бензодиазепиновых и небензодиазепиновых снотворных средств, таких как залеплон, золпидем и зопиклон. В ходе клинического исследования наблюдались четкие признаки транзиторного фармакодинамического взаимодействия между мелатонином и золпидемом спустя час после их приема. Комбинированное применение может приводить к прогрессирующему расстройству внимания, памяти и координации в сравнении с монотерапией золпидемом.\u003Cbr\u003E- В ходе исследований мелатонин назначался совместно с тиоридазином и имипрамином, препаратами, которые влияют на центральную нервную систему. Ни в одном из случаев не было выявлено клинически значимого фармакокинетического взаимодействия. Тем не менее, одновременное применение с мелатонином приводило к повышению ощущения спокойствия и к затруднениям в выполнении определенных заданий в сравнении с монотерапией имипрамином, а также к усилению чувства \"помутнения в голове\", в сравнении с монотерапией тиоридазином."},{"name":"Регистрационный номер","value":"ЛП-005295"},{"name":"Дата государственной регистрации","value":"14.01.2019"},{"name":"Владелец регистрационного удостоверения","value":"Эвалар"},{"name":"Изготовитель","value":"Эвалар"},{"name":"Фасовщик","value":"Эвалар"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мелатонин Эвалар"},{"name":"Срок годности","value":"25 мес."}]}],"transitionId":"tr_5435782739802890788"}}}}
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Цена с картой Яндекс Пэй:701 ₽

Скидка: 2%
–2 %
Вместо: 715 ₽
  • 18 июня, курьер Маркета • 99 ₽
POLZAru
Рейтинг 4.9 из 5
38Котзывов
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  • Сонные+ таб., 30 шт., 1 уп.
    –33 %
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    Сонные+ таб., 30 шт., 1 уп.

    Рейтинг товара: 4.1 из 5
    на основе 149 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 269 ₽ вместо 275
    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  • Формула сна экспресс таб. д/рассас., 40 шт.
    –1 %
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    Формула сна экспресс таб. д/рассас., 40 шт.

    Рейтинг товара: 3.7 из 5
    на основе 3 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 483 ₽ вместо 488
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  • Формула Спокойствия Триптофан капс., 15 шт.
    –1 %
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    Формула Спокойствия Триптофан капс., 15 шт.

    Рейтинг товара: 4.6 из 5
    на основе 29 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 452 ₽ вместо 457
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  • 5-HTP капс., 50 мг, 0.44 г, 30 шт., 1 уп.
    –55 %
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    5-HTP капс., 50 мг, 0.44 г, 30 шт., 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 88 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 689 ₽ вместо 710
    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  • GLS Триптофан капс., 500 мг, 0.25 г, 90 шт.
    –10 %
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    GLS Триптофан капс., 500 мг, 0.25 г, 90 шт.

    Рейтинг товара: 4.8 из 5
    на основе 23 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 540 ₽ вместо 550
    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Триптофан капс., 500 мг, 0.25 г, 90 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  • Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.
    –1 %
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    Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 772 ₽ вместо 780
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  • Формула сна усиленная фито-мелатонином капс., 30 шт.
    –1 %
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    Формула сна усиленная фито-мелатонином капс., 30 шт.

    Рейтинг товара: 4 из 5
    на основе 11 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 613 ₽ вместо 619
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  • Гинкго Билоба Эвалар таб., 0.5 г, 60 шт., 1 уп.
    –2 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-z031wwthq4/toggleWishlist":{"skuId":"455745460","productId":1404748592,"offerId":"NrtZ0X-bEAiaDAoh-xFMww","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6+K+gNy/gpYiEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIsIbrnQUQtL+o2QEY1buhBiDt2cEH","sign":"6HPsApqaOS8N8xb+ZZ4N81T9e9qDgSr+1XnvhY5SRtE="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-z031wwthq4/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гинкго Билоба Эвалар таб., 0.5 г, 60 шт., 1 уп.

    Рейтинг товара: 3 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 507 ₽ вместо 1 537
    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Билоба Эвалар таб., 0.5 г, 60 шт., 1 уп.","label":"08rwg081kcqm","count":0,"features":[],"imageMeta":{"namespace":"mpic","groupId":1715213,"key":"img_id1458619389901826307.png"}},"quantity":{"step":1,"minimum":1,"maximum":999},"cpaUrl":"/safeclick/data=TxNGOK9vJEN7oLFLeCTKEg29zEwz0Mco8qOIZtoU3uCO7NJCFDfKt0NJA58Rz8V22A0DJx1aRh1K8p0SKPmK6eZJSMwuAfqM_vtM8YtxvDP8vKtbvYpe_pvsJ91_0PA5f3GHQ2844VYmRb7iApVy3syQziL5dn3RwLYs43xcmDroiQZK_cjHQ7pj7eB1CkF_KCwLUWINYri9xTADJhr02PtWd95Mt699Rm-1G6hIIZkDcKbz-JIkazwSUCqV3mmNB2BMVULGT6VR7lF91oLXyqCvRKkii-Q3yeOA0WnYSjdWfpLUp1VqrquSqHv4tpAae0rYXBUIGDNaKhqdWhtpGYfp02qgMgTkcY--KDnyVmFthGh_pGh5NALkwLBbMUrIiUYTtyrX4aVEc3O0N6fW8bR3PG4DgwizCTPqpyATVhOIN3uGyXod2pwoFva6P22WvrpIaLtciHKwBgqp9sR5vuSKPiVtE4phevcU4Vz4yrT4LH_rE0DN3ml-7Y8dM2GfgFl_HVRVpvo1hNZWWDHM6zBg6Fi8i3JfyMMQRYaaMd45TtIp5ZEfr1PR-S8Vfy5VSsUO2pb6M32FvFC0FgSWhD-OWOkMgXhFwM7-GpKtTfkDS--UfHw5vhBSajAsoWaWAf1jJc_Qj7Iw299ooATb0cKEiksHmBIFQtRI7yJDKDFGaG15pcgJh5aRM5kAkohWrE3RaJWWMw--CsSrsa5zXw8OIn5Juu73pZ8Zh3GLqUwmpHBJj3bE16ov9XBsRlL9YsxBiUGZz8zjv6j1o61GbGCbgNCEJl2pF2dIbZvjSPHCsW-e50dxdLdpC0OGmfBjCpu50ylIHR7pXUlbcrGPcaYa1g7EQTjAhaV5e3hozGm9NOeUsOwkvQrDhatbRagTwW3TJD0_AlS0lz9gUq-0SrqgG61olV4hdcqhhl_UuQetk6y-bzS-E0xs73bxKI_c-x5pdohb9CBFPkY1q4mVJxX3B1dkbBhtKqGEJ-hjfmIQdcPhwHOjwP5hsvY2Tz8oBOE0xEXW5OFXFy_WA7EDCyFSUHjB0sZvnLt2xWb8J-i4mmI_BxwDKwWWLBHdkN6d4fNZdQ4GgH3AQeoLEejM8H5RntWZ2O0LSN8aZgkLzrREkrFvTqfMI_IOc8RBajcOxac9AjWyfUmwfFX2h36GOfcB-WOufMC_gXrh3Rr2w0VACWlvaZIRw9uZrWn_7XfBzvymMVmFMYEavqFveGnfB4c9DlBbjdPM602Xb7GUU9mCJQMWrXYJLR_2DhF_u-B5Wxlufgn9TmcvoLdH8GmMTACszHXmUNsJjVK_rzhbqHvrw-vf2pgscyHBnK4pE4nZaQSRhGjUifT81GVVQvx9RZY4umlSjRl62dUYvFakLVvkq37zL5NBtqGh3UGRTrxDjbRsO8eWRJuCCpAfOiEtEluHPXXwQEWC3JqdAHM_qe-FzdERidfsQexN91GV6eWl_Zn2-4-i9Mg7c7b0yvyOf7dsmiBxyvdR0cKxBOOGUjyav-xvfbD8joEZH2Gy2ANFkYKeCeaJ8CrRnUW7IbzQt-73BszIO8A5eCG0r2zPbfVwn1mUpNp4owTyDJednSslb0U_eKAObVf6CfMCCM5fbLBTk4CtN0La-JLR_BK_KD-_tbRGMzXq_sFNsyZXkxEzNcSnQB4N88YSwwmujYI8CbFfmmyJFxMi-PBlUzCJeojy51pLL8dNo0LkjZeVFsUFK5BOdI0udpXrPGz5InHwMneliUyYenw4S2vCiPq3bC-iGT5d7WMcuGDR6EuFv4rOqUv0mvLouxqI62aE7gofsfsiJ9XAHYuHr5-UZkCVhyy7StLg2WHBvmaq0u7sxMHss6SNGI201Cz2S6kZMg96aywngHTvogFHfSgQsiorpja26Kto3HDxPRjw7EYXQLxg1VPrgFVhc4JvGI55ywx1rRQc1uZ9Rs2Yldko_Gu3NpTP2zbOS_BN6dC-Vudz-9fhtIQZjto2O5F6i31RwqNk5bF8q7BUSbLMnRA6ckuW5zQmmSg0eEXFZiaG1KWp0Tn-bzBJast6YCrNhmjeV69_C4bbLJNYnpqv1i0c1kR5xDF6RTxIAQ2ZbJ2zX1JxE8tqtwFC5VKxAtk2Nd2T9sBrf7ZcauL2lVAQrLbl5AKqJgN_wCs8t3wInotYZH4JZYXH63koKcGZLw5VugLgSueayPiE9VkQdHR9QHisv9T-rkT2QdYwI72buDjSN8cLH8YBXceAenWW-mQ7Y44jUGcB03hl2L7ftyTPY2O0z-q-3OPwpVm0jipkopO-ScnMN_uL0GC1r9yPla4Rbd-y-X6UtUubOyw_ol3CD6y0dBEuEZL_bAOVWe61CGnjbz6LZ6CAUTgloCOjNMIC9XCCORfY17ulJ1GhsM8u5313awTVRtgRhxOoAVlx1qa39YyfG7g-Z3mXf-W6S34jwmj0f0qhUtpcFuPLt_GIEv7YbdtI70sLYF_c5lmuAXVn79lRyJfVwwMzBTEL0KKtRpETAJVA3HOtjjg8owA3SW_lB_89G8yMz4raCUdY06pCgTC_qFSUhvfF_FQdiiBdL4YaJHGRBTQc_gp7CfzfoGZDd19CqHOVVwgNXWloHd5NJkazctAqBJ69sQ8F5zD_KNyoRmsTBWS3FB7O-ANtbHPiDqtL3bt4bsYt60bP59Fn4_Nuhh0W6fvFMKdekrsMoavzfw_2tiEEu2F8Iim9BrQUmSOwV0FyRBizmR1YSofLgVqQjIoF_tlF5O53SeFX5ud28bIQ90w8PxTVWiVrNlvMh7dkHIn8qINyr56Suwm913tjvCs9-aopMSIqiA9xxxOkRfh9NBpKR8CVYJvgqm5bcxSNuq23qCYkx0wxIWMYV8OQDYLhfRKTEVE5qcUmLZVLLvQMshdyWbViNAj8zojsi0xZ5dVD-H_-tS-L2BP_SJ1jBWVywii_SuyTYv0O0m8aX-OX-2YMziIGGQrkDeeH3h4-bjaE6uZZKjyFEg76SHQGq0QhD-IUZXeRNpSbZ75I-zcVFPstX3ampQco8kOVU4YuJNWqFk63KpL8M7JiPY-9UCt06gULckRaOcu92NB1ckpgv3193HFSXEfk-PERn6lGen0Cdfzskxm_lukvZc3Wn5nPIVTkt5Jzh0i57sB_UoWtoGvUPxP4EIg4jmUZ1GtpaPEPJ49V5yAQCRJjPUaFXrVvCJ0d3sOSwfC11tIVwM3rYRBw_F6qcbmymdnVOXQehavDitGV5q26XGfxODn0XlVD3PztNBdulxT8gHXIBt5jpvV-s02BXZEm5MjXRc4hmp5gAfuxGIjMT4Z6vHFLPqKAYrlFNoRBZ6uv1UAlzN5nyRMhMGY0E3qtRQTdgzk1v_rMeXJwkLA89cf30AMlbHSSYszobBfRIb42KAN_btItuFn4gZH-yrCOckf3aw0Qh65QcqiKZLdVbQw4BXKBmxylE4CcuoBjQcc1f3ogkQmQZt2968dXMl3jsolFHcE_QvjnpRvwOYXcF-57wQvZTscvxI23Pg9nO7v0xhLAeG70NWIHsEEM1GoFThmCSl64jmlC_zHo9LhZYpZ2LCsM50nQJP4hFZke2DK6eGB-_BsunlI7v1OpFBhfoKRqQanjZw0BlWQCtCzW-G_1n78RoL1wpORYvGm3WZ92DPXAPmgIZA3ROFNE26GopN-CyaMsQOeRARHwmZk44Drq_JewV9JBLLaSJI0-eZ9vVeZxpVZ5aw,,/b64e=1/sign=e0ab7d416d6def8ee60b8ac94e65269b/keyno=MARKET_1/*","showUid":"17184485872516337157006009","cartLink":"/my/cart","showNotificationWhenDeleteItem":true,"isLavka":false,"isError":false,"isEats":false,"isCR":false,"isM2bEdoOnlyEnable":false,"isEatsMarketIntegration":true,"isCartButtonNext":false,"isUpsalePopupCRExp":false,"baobabClientDataAdditionToCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6+K+gNy/gpYiEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIsIbrnQUQtL+o2QEY1buhBiDt2cEH","sign":"6HPsApqaOS8N8xb+ZZ4N81T9e9qDgSr+1XnvhY5SRtE="},"target":"cart_addition"},"baobabClientDataDeletionFromCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6+K+gNy/gpYiEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIsIbrnQUQtL+o2QEY1buhBiDt2cEH","sign":"6HPsApqaOS8N8xb+ZZ4N81T9e9qDgSr+1XnvhY5SRtE="},"target":"cart_deletion"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-z031wwthq4/addToCartButton":{"name":"@light/AddToC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  • Релаксозан День таб., 40 шт.
    –2 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-9cm3r7kpzr/toggleWishlist":{"skuId":"662913030","productId":1404748725,"offerId":"vlofFuboBG9cplvDff8e6w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6+K+gNy/gpYiEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYItYfrnQUQhoCNvAIY1buhBiDt2cEH","sign":"bjmDGaoChr5BZb7D9SnA3HaMf+oHItQotsbjGIY5x+M="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-9cm3r7kpzr/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Релаксозан День таб., 40 шт.

    Рейтинг товара: 4.7 из 5
    на основе 124 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 669 ₽ вместо 683
    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День таб., 40 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  • Формула сна таб., 40 шт., 1 уп.
    –1 %
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    Формула сна таб., 40 шт., 1 уп.

    Рейтинг товара: 4.2 из 5
    на основе 21 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 409 ₽ вместо 413
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  • Natrol Melatonin таб., 3 мг, 100 г, 60 шт.
    –28 %
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    Natrol Melatonin таб., 3 мг, 100 г, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 558 ₽ вместо 1 590
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Melatonin таб., 3 мг, 100 г, 60 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Инструкция

Показания к применению

При расстройствах сна, в т.ч. обусловленных нарушением ритма "сон-бодрствование", таких как десинхроноз (резкая смена часовых поясов).

Противопоказания

Гиперчувствительность к компонентам препарата, аутоиммунные заболевания, печеночная недостаточность, тяжелая почечная недостаточность, детский возраст до 18 лет, беременность, период грудного вскармливания.

Способ применения и дозы

Внутрь.
При нарушении сна - по 3 мг один раз в сутки за 30-40 минут до сна.
При десинхронозе в качестве адаптогена при смене часовых поясов - за 1 день до перелета и в последующие 2-5 дней - по 3 мг за 30-40 минут до сна.
Максимальная суточная доза - 6 мг.
Пожилые пациенты
С возрастом происходит снижение метаболизма мелатонина, что необходимо учитывать при выборе режима дозирования для пожилых пациентов. С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.
Пациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется.
Полная инструкция
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Мелатонин Эвалар таб. п/о плен.
Мелатонин Эвалар таб. п/о плен., 3 мг, 40 шт., 1 уп.
4.6
(97)
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13 вопросов
Инструкция

Цена с картой Яндекс Пэй:701 ₽

Скидка: 2%
–2 %
Вместо: 715 ₽
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4.6
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У продавца:97 оценок·25 отзывов
У всех продавцов:708 оценок·294 отзыва
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user avatar
4 месяца назад • Andry Goryachev • Куплен на Маркете
Комментарий: Пользую около года-возраст даёт себя знать. Метода употребления-отбой 21-00,таблетку рассосать за 20 минут до желаемого времени засыпания. Нормальный сон до 7....8 утра. Помогает в 80% случаев.
user avatar
9 месяцев назад • Ольга Т. • Куплен на Маркете
Комментарий: Супер вещь! Выпиваешь и после 30-40 минут обязательно нужно лечь спать, или хотя бы просто полежать закрытыми глазами если не спится, уснëте в любом случае, если соблюдать это правило, тогда действует очень эффективно. Спишь до утра сладким сном и при этом утром чувствуешь себя бодро, наполненным энергией и силами.
user avatar
2 месяца назад • katurs • Куплен на Маркете
Достоинства: Лёгкий снотворный эффект. Препарат не вызывает привыкания. Отпускается без рецепта.
Недостатки: Очевидных не нашел.
Комментарий: Надеюсь и дальше смогу пользоваться при необходимости.
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  • Сонные+ таб., 30 шт., 1 уп.
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    Сонные+ таб., 30 шт., 1 уп.

    Цена 269 ₽ вместо 399
  • Глицин Форте Эвалар таб. д/расс., 500 мг, 60 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748541_4/content/content/toggleWishlist":{"skuId":"641079100","productId":1404748541,"offerId":"T_hRpBrtlyPXN8k84WY0tQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6+K+gNy/gpYiEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCP2F650FELyu2LECGNW7oQYgmcMF","sign":"raEssiNE5eMC/uH4hy2KoACtKd9CZAbBxWJbCclOSKc="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748541_4/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Глицин Форте Эвалар таб. д/расс., 500 мг, 60 шт.

    Цена 487 ₽ вместо 610
  • Уголь активированный таб., 250 мг, 50 шт.
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    Уголь активированный таб., 250 мг, 50 шт.

    Цена 50 ₽
  • Мезим Форте таб. п/о, 20 шт.
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    Мезим Форте таб. п/о, 20 шт.

    Цена 103 ₽ вместо 105
  • Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.
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    Реасон Мелатонин капс., 2 мг, 60 шт., 1 уп.

    Цена 772 ₽ вместо 780
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    Реклама
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  • Панкреатин таб. п/о кш/раств. (блистеры), 25 ЕД, 20 шт.
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    Панкреатин таб. п/о кш/раств. (блистеры), 25 ЕД, 20 шт.

    Цена 35 ₽
  • Формула сна усиленная фито-мелатонином капс., 30 шт.
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    Формула сна усиленная фито-мелатонином капс., 30 шт.

    Цена 613 ₽ вместо 619
  • Эрмиталь капc. кш/раств., 10000 ЕД, 20 шт.
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    Эрмиталь капc. кш/раств., 10000 ЕД, 20 шт.

    Цена 207 ₽ вместо 209
  • Эвалар Витамин Д3 максимум 2000 МЕ 120 капсул
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    Эвалар Витамин Д3 максимум 2000 МЕ 120 капсул

    Цена 531 ₽ вместо 596
  • Витамин Д3 + К2 таб. жев., 1200 МЕ, 0.22 г, 60 шт.
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    Витамин Д3 + К2 таб. жев., 1200 МЕ, 0.22 г, 60 шт.

    Цена 408 ₽ вместо 412
  • Формула сна таб., 40 шт., 1 уп.
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    Формула сна таб., 40 шт., 1 уп.

    Цена 409 ₽ вместо 413
  • GLS Триптофан капс., 500 мг, 0.25 г, 90 шт.
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    GLS Триптофан капс., 500 мг, 0.25 г, 90 шт.

    Цена 540 ₽ вместо 600
  • Гинкго Билоба Эвалар таб., 0.5 г, 40 шт., 1 уп.
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    Гинкго Билоба Эвалар таб., 0.5 г, 40 шт., 1 уп.

    Цена 428 ₽ вместо 432
  • Полисорб МП пор. д/приг. сусп. д/вн. приема, 12 г
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    Полисорб МП пор. д/приг. сусп. д/вн. приема, 12 г

    Цена 274 ₽ вместо 277
  • Снуп спрей наз., 90 мкг/доза, 15 мл
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    Снуп спрей наз., 90 мкг/доза, 15 мл

    Цена 139 ₽ вместо 154
  • Релаксозан День таб., 20 шт.
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    Релаксозан День таб., 20 шт.

    Цена 488 ₽ вместо 493
  • Хлоргексидина биглюконат р-р д/мест. и нар. прим. фл., 0,05%, 100 мл
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857714_20/content/content/toggleWishlist":{"skuId":"649376077","productId":1780857714,"offerId":"EY9WNDmXUKYLoAAvyAYFrA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6+K+gNy/gpYiEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCPL2ltEGEM3i0rUCGI2CzwYg5dnBBw==","sign":"p7odMhjn9ClxxGRZse0ok5OLExHAQyT5JScuVJNzUt0="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857714_20/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Хлоргексидина биглюконат р-р д/мест. и нар. прим. фл., 0,05%, 100 мл

    Цена 17 ₽
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    Реклама
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  • Магний В6 таб., 1.25 г, 60 шт.
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    Магний В6 таб., 1.25 г, 60 шт.

    Цена 382 ₽ вместо 407
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 1 752 ₽ вместо 3 500
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