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Метопролол ретард-Акрихин таб. пролонг. действ. п/о плен., 50 мг, 30 шт.

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5.0
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Дозировка: 50 мг

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Коротко о товаре

Артикул Маркета
3288420984
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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мм рт. ст.), период грудного вскармливания, одновременный прием ингибиторов моноаминоксидазы (МАО) или одновременное в/в введение верапамила, феохромоцитома (без одновременного приема альфа-адреноблокаторов), возраст до 18 лет (эффективность и безопасность не установлены), дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция, тяжелая бронхиальная астма, тяжелые нарушения периферического кровообращения."},{"name":"Состав","value":"Одна таблетка содержит:\u003Cbr\u003Eдействующее вещество: метопролола сукцинат 23,83 мг, 47,66 мг и 95,32 мг, что эквивалентно 25 мг, 50 мг и 100 мг метопролола тартрата соответственно;\u003Cbr\u003Eвспомогательные вещества: гипромеллоза 155,96 мг, 161,92 мг и 184,84 мг; лудипресс ЛЦЕ [лактозы моногидрат 94,7-98,3 %, повидон 3-4 %] 117,21 мг, 87,42 мг или 412,84 мг; кремния диоксид коллоидный 1,5 мг, 1,5 мг или 3,5 мг; магния стеарат 1,5 мг, 1,5 мг или 3,5 мг соответственно.\u003Cbr\u003EСостав оболочки:\u003Cbr\u003EДля таблеток с дозировками 25 мг и 100 мг - готовая смесь \"Опадрай II\" оранжевого цвета (поливиниловый спирт 6 мг или 14 мг, тальк 2,22 мг или 5,18 мг, макрогол 3,03 мг или 7,07 мг, титана диоксид 3,36 мг или 7,84 мг, краситель железа оксид красный 0,009 мг или 0,021 мг, краситель железа оксид желтый 0,378 мг или 0,882 мг, краситель железа оксид черный 0,003 мг или 0,007 мг) 15 мг или 35 мг соответственно.\u003Cbr\u003EДля таблеток с дозировкой 50 мг - готовая смесь \"Опадрай II\" зеленого цвета (поливиниловый спирт 6 мг, тальк 2,22 мг, макрогол 3,03 мг, титана диоксид 2,925 мг, краситель хинолиновый желтый (алюминиевый лак) 0,268 мг, краситель железа оксид черный 0,015 мг, краситель индигокармин (алюминиевый лак) 0,542 мг) 15 мг."},{"name":"Действующее вещество","value":"Метопролол","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["27144131:28710777"]}}},{"name":"Способ применения и дозы","value":"Препарат Метопролол ретард-Акрихин принимают внутрь 1 раз/сут. Таблетки рекомендуется принимать утром, не разжевывая, запивая водой. Метопролол ретард-Акрихин можно принимать независимо от приема пищи.\u003Cbr\u003EС целью предотвращения брадикардии дозу подбирают индивидуально и увеличивают постепенно.\u003Cbr\u003EПри артериальной гипертензии и стенокардии начальная доза - 50 мг 1 раз/сут, при недостаточном терапевтическом эффекте суточная доза может быть увеличена до 100-200 мг/сут. При артериальной гипертензии при неэффективности препарата в дозе 100-200 мг/сут можно добавить другое гипотензивное средство.\u003Cbr\u003EПри хронической сердечной недостаточности II функционального класса по классификации NYHA (без обострений последние 6 недель и без изменения в комплексной терапии в течение последних 2 недель) рекомендуемая начальная доза - 25 мг 1 раз/сут. Через 2 недели суточную дозу можно повысить до 50 мг, затем через 2 недели - до 100 мг, еще через 2 недели - до 200 мг.\u003Cbr\u003EПри хронической сердечной недостаточности III-IV функционального класса по классификации NYHA рекомендуемая начальная доза - первые 2 недели 12.5 мг 1 раз/сут. Возможно применение метопролола в другой лекарственной форме, например, таблетки по 25 мг с риской. В период увеличения дозы пациент должен находиться под наблюдением, т.к. у некоторых пациентов симптомы сердечной недостаточности могут ухудшиться.\u003Cbr\u003EЧерез 1-2 недели доза может быть увеличена до 25 мг 1 раз/сут. Затем через 2 недели доза может быть увеличена до 50 мг 1 раз/сут. Пациентам, которые хорошо переносят препарат, можно удваивать дозу каждые 2 недели до достижения максимальной дозы 200 мг 1 раз/сут.\u003Cbr\u003EПри вторичной профилактике инфаркта миокарда и нарушений сердечного ритма начальная доза составляет 100 мг 1 раз/сут.\u003Cbr\u003EПри функциональных нарушениях сердечной деятельности, сопровождающихся тахикардией, назначают по 50 мг/сут, при необходимости дозу можно увеличить до 200 мг/сут. \u003Cbr\u003EДля профилактики приступов мигрени назначают по 100-200 мг 1 раз/сут.\u003Cbr\u003EПациентам пожилого возраста, пациентам с почечной недостаточностью или пациентам, находящимся на гемодиализе, коррекции дозы не требуется.\u003Cbr\u003EНарушения функции печени влияют на выведение метопролола, поэтому может потребоваться коррекция дозы в зависимости от клинического состояния.\u003Cbr\u003E"},{"name":"Побочные действия","value":"Частота побочных эффектов: очень часто - более 1/10, часто - более 1/100 и менее 1/10, нечасто - более 1/1000 и менее 1/100, редко - более 1/10000 и менее 1/1000, очень редко - менее 1/10000, включая отдельные сообщения.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: часто - брадикардия, ортостатическая гипотензия (в т.ч. с обмороком), похолодание нижних конечностей, ощущение сердцебиения; нечасто - временное усиление симптомов сердечной недостаточности, кардиогенный шок у пациентов с инфарктом миокарда, AV блокада I степени; редко - нарушения проводимости миокарда, аритмия; очень редко - гангрена (у пациентов с нарушениями периферического кровообращения).\u003Cbr\u003EСо стороны центральной нервной системы: очень часто - повышенная утомляемость, снижение скорости психических и двигательных реакций; часто - головокружение, головная боль; нечасто - парестезии, судороги, депрессия, снижение концентрации внимания, сонливость, бессонница, \"кошмарные\" сновидения; редко - астения, тремор, повышенная нервная возбудимость, тревога; очень редко - амнезия/нарушение памяти, подавленность, галлюцинации, миастения.\u003Cbr\u003EСо стороны органов чувств: редко - нарушение зрения, сухость и/или раздражение глаз, конъюнктивит; очень редко - звон в ушах, нарушение вкусовых ощущений.\u003Cbr\u003EСо стороны пищеварительной системы: часто - тошнота, боль в животе, запор или диарея; нечасто - рвота; редко - сухость слизистой оболочки полости рта, нарушение функции печени, гепатит.\u003Cbr\u003EСо стороны кожных покровов: нечасто - крапивница, усиление потоотделения; редко - алопеция; очень редко - фотосенсибилизация, обострение течения псориаза, псориазоподобные кожные реакции.\u003Cbr\u003EСо стороны дыхательной системы: часто - одышка; нечасто - бронхоспазм у пациентов с бронхиальной астмой; редко - ринит.\u003Cbr\u003EЛабораторные показатели: очень редко - тромбоцитопения (необычные кровотечения и кровоизлияния), агранулоцитоз, лейкопения, повышение активности \"печеночных\" ферментов, гипербилирубинемия.\u003Cbr\u003EСо стороны эндокринной системы: часто - гипогликемия (у пациентов с сахарным диабетом I типа), редко - гипергликемия (у пациентов с сахарным диабетом II типа), гипотиреоидное состояние.\u003Cbr\u003EПрочие: нечасто - увеличение массы тела; редко - импотенция/сексуальная дисфункция; очень редко - артралгия, тромбоцитопения."},{"name":"Фармакологическое действие","value":"Кардиоселективный бета1-адреноблокатор. Не оказывает мембраностабилизирующего действия и не обладает внутренней симпатомиметической активностью. Обладает антигипертензивным, антиангинальным и антиаритмическим действием.\u003Cbr\u003EБлокируя в невысоких дозах бета1-адренорецепторы сердца, уменьшает стимулированное катехоламинами образование циклического аденозинмонофосфата (цАМФ) из аденозинтрифосфата (АТФ), снижает внутриклеточный ток ионов кальция, оказывает отрицательное хроно-, дромо-, батмо- и инотропное действие (урежает частоту сердечных сокращений (ЧСС), угнетает проводимость и возбудимость, снижает сократимость миокарда).\u003Cbr\u003EОбщее периферическое сосудистое сопротивление (ОПСС) в начале применения бета-адреноблокаторов (в первые 24 ч после перорального приема) увеличивается (в результате реципрокного возрастания активности альфа-адренорецепторов и устранения стимуляции бета2-адренорецепторов), которое через 1-3 дня возвращается к исходному, а при длительном назначении снижается.\u003Cbr\u003EАнтигипертензивное действие обусловлено уменьшением минутного объема кровотока и синтеза ренина, угнетением активности ренин-ангиотензин-альдостероновой системы (имеет большее значение у пациентов с исходной гиперсекрецией ренина) и центральной нервной системы, восстановлением чувствительности барорецепторов дуги аорты (не происходит усиления их активности в ответ на снижение артериального давления (АД) и в итоге уменьшением периферических симпатических влияний. Снижает повышенное АД в покое, при физическом напряжении и стрессе. Антигипертензивный эффект длится более 24 часов.\u003Cbr\u003EАнтиангинальный эффект определяется снижением потребности миокарда в кислороде в результате уменьшения ЧСС (удлинение диастолы и улучшение перфузии миокарда) и сократимости, а также снижением чувствительности миокарда к воздействию симпатической иннервации.\u003Cbr\u003EУменьшает число и тяжесть приступов стенокардии и повышает переносимость физической нагрузки. За счет повышения конечного диастолического давления в левом желудочке и увеличения растяжения мышечных волокон желудочков может повышать потребность в кислороде, особенно у пациентов с хронической сердечной недостаточностью (ХСН).\u003Cbr\u003EАнтиаритмический эффект обусловлен устранением аритмогенных факторов (тахикардии, повышенной активности симпатической нервной системы, увеличенного содержания цАМФ, артериальной гипертензии), уменьшением скорости спонтанного возбуждения синусного и эктопического водителей ритма и замедлением атриовентрикулярного (AV) проведения (преимущественно в антеградном и в меньшей степени в ретроградном направлениях через AV узел) и по дополнительным путям.\u003Cbr\u003EПри суправентрикулярной тахикардии, мерцании предсердий, синусовой тахикардии при функциональных заболеваниях сердца и тиреотоксикозе урежает ЧСС или даже может привести к восстановлению синусного ритма.\u003Cbr\u003EПредупреждает развитие мигрени.\u003Cbr\u003EВ отличие от неселективных бета-адреноблокаторов при назначении в средних терапевтических дозах оказывает менее выраженное влияние на органы, содержащие бета2-адренорецепторы (поджелудочная железа, скелетные мышцы, гладкая мускулатура периферических артерий, бронхов и матки) и на углеводный обмен; выраженность атерогенного действия не отличается от действия пропранолола.\u003Cbr\u003EПри многолетнем приеме снижает концентрацию холестерина в крови. При применении в больших дозах (более 100 мг/сут) оказывает блокирующий эффект на оба подтипа бета-адренорецепторов."},{"name":"Фармакологическая группа","value":"бета1-адреноблокатор селективный"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Токсичность: метопролол в дозе 7,5 г у взрослого вызвал интоксикацию с летальным исходом. У 5-ти летнего ребенка, принявшего 100 мг метопролола, после промывания желудка не отмечалось признаков интоксикации. Прием 450 мг метопролола подростком 12 лет привел к умеренной интоксикации. Прием 1,4 г и 2,5 г метопролола взрослыми вызвал умеренную и тяжелую интоксикацию, соответственно. Прием 7,5 г взрослым привел к крайне тяжелой интоксикации.\u003Cbr\u003EСимптомы: выраженная брадикардия, AV блокада (вплоть до развития полной поперечной блокады и остановки сердца), выраженное снижение АД, нарушение периферического кровообращения, усиление симптомов сердечной недостаточности, кардиогенный шок, угнетение дыхания, апноэ, цианоз, повышенная утомляемость, головокружение, потеря сознания, кома, тремор, судороги, повышение потоотделения, парестезии, бронхоспазм, тошнота, рвота, возможно развитие эзофагоспазма, гипогликемия или гипергликемия, гиперкалиемия, преходящая миастения. Первые признаки передозировки проявляются через 20 мин-2 ч после приема препарата.\u003Cbr\u003EЛечение: Если препарат принят недавно - промывание желудка и прием адсорбирующих средств; Атропин (0,25-0,5 мг в/в для взрослых, 10-20 мкг/кг для детей) должен быть назначен до промывания желудка (риск стимуляции блуждающего нерва). При нарушении атриовентрикулярной проводимости и/или брадикардии - в/в введение 1-2 мг атропина, эпинефрина (адреналина) или постановка временного кардиостимулятора; при снижении артериального давления - пациент должен находиться в положении Тренделенбурга. Если нет признаков отека легких - в/в плазмозамещающие растворы, при неэффективности - введение эпинефрина, допамина, добутамина. Можно также применять глюкагон 50-150 мкг/кг в/в с интервалом в 1 минуту (оказывает положительное инотропное и хронотропное действие на миокард); при острой сердечной недостаточности - сердечные гликозиды, диуретики; при судорогах - в/в диазепам; при бронхоспазме - ингаляционно или парентерально бета2-адреномиметики."},{"name":"Применение при беременности и кормлении грудью","value":"Как и большинство бета-адреноблокаторов, препарат Метопролол ретард-Акрихин не следует применять при беременности и в период грудного вскармливания, за исключением тех случаев, когда ожидаемая польза для матери превышает потенциальный риск для плода и/или ребенка. Как и другие гипотензивные средства, бета-адреноблокаторы могут вызывать побочные эффекты, например, брадикардию у плода, новорожденных или детей, находящихся на грудном вскармливании.\u003Cbr\u003EКоличество метопролола, которое проникает в грудное молоко, и бета-адреноблокирующее действие метопролола у ребенка, находящегося на грудном вскармливании (при приеме матерью метопролола в терапевтических дозах), являются незначительными. Рекомендуется следить за появлением признаков блокады бета-адренергических рецепторов у грудных детей (в случае, если кормящая мать получает терапию препаратом)."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Контроль больных, принимающих бета-адреноблокаторы, включает регулярное наблюдение за ЧСС и АД. Следует обучить больного методике подсчета ЧСС и проинструктировать о необходимости врачебной консультации при ЧСС менее 50 уд./мин.\u003Cbr\u003EВозможно усиление выраженности аллергических реакций (на фоне отягощенного аллергологического анамнеза) и отсутствие эффекта от введения обычных доз эпинефрина (адреналина).\u003Cbr\u003EУ пожилых пациентов рекомендуется осуществлять контроль функции почек (1 раз в 4-5 мес). \u003Cbr\u003EПрием препарата Метопролол ретард-Акрихин может усилить симптомы нарушения периферического артериального кровообращения.\u003Cbr\u003EПри стенокардии напряжения подобранная доза препарата должна обеспечивать ЧСС в покое в пределах 55-60 уд./мин, при нагрузке - не более 110 уд./мин. \u003Cbr\u003EУ курящих пациентов эффективность бета-адреноблокаторов ниже.\u003Cbr\u003EМетопролол ретард-Акрихин может маскировать некоторые клинические проявления тиреотоксикоза (например, тахикардию). Резкая отмена препарата у больных с тиреотоксикозом противопоказана, поскольку способна усилить симптоматику.\u003Cbr\u003EПри сахарном диабете прием препарата Метопролол ретард-Акрихин может маскировать тахикардию, вызванную гипогликемией. \u003Cbr\u003EПри необходимости назначения пациентам с бронхиальной астмой в качестве сопутствующей терапии используют бета2-адреномиметики; при феохромоцитоме - альфа-адреноблокаторы.\u003Cbr\u003EПри необходимости проведения хирургического вмешательства необходимо предупредить врача-анестезиолога о приеме препарата Метопролол ретард-Акрихин (необходим выбор средства для общей анестезии с минимальным отрицательным инотропным действием), отмена препарата не рекомендуется.\u003Cbr\u003EРеципрокную активацию блуждающего нерва можно устранить в/в введением атропина (1-2 мг).\u003Cbr\u003EВ случае появления нарастающей брадикардии (менее 50 уд/мин), артериальной гипотензии (систолическое АД ниже 100 мм рт.ст.), AV-блокады, бронхоспазма, желудочковых аритмий, тяжелых нарушений функции печени и почек необходимо уменьшить дозу или прекратить лечение.\u003Cbr\u003EРекомендуется прекращать терапию при появлении кожных высыпаний и развитии депрессии, вызванной приемом бета-адреноблокаторов.\u003Cbr\u003EПри резкой отмене клонидина может резко повышаться АД, при одновременном приеме бета-адреноблокаторов. В случае отмены клонидина, прекращение приема бета-адреноблокаторов следует начинать за несколько дней до отмены клонидина. \u003Cbr\u003EПрепараты, снижающие запасы катехоламинов (например, резерпин), могут усилить действие бета-адреноблокаторов, поэтому пациенты, принимающие такие сочетания препаратов, должны находиться под постоянным медицинским наблюдением на предмет выявления чрезмерного снижения АД или брадикардии.\u003Cbr\u003EПри резком прекращении лечения может возникнуть синдром отмены (усиление приступов стенокардии, повышение АД). Особое внимание при отмене препарата необходимо уделять больным стенокардией, хронической сердечной недостаточностью, после перенесенного инфаркта миокарда. Отмену препарата Метопролол ретард-Акрихин проводят постепенно, сокращая дозу в течение 10 дней. \u003Cbr\u003EПациенты, пользующиеся контактными линзами, должны учитывать, что на фоне лечения бета-адреноблокаторами возможно уменьшение продукции слезной жидкости."},{"name":"Взаимодействие","value":"Средства, снижающие запасы катехоламинов, (например, резерпин, ингибиторы МАО) при одновременном применении с метопрололом могут усилить гипотензивное действие или вызвать выраженную брадикардию. Перерыв в лечении между приемом ингибиторов МАО и метопролола должен составлять не менее 14 дней.\u003Cbr\u003E\nМетопролол является субстратом изофермента CYP2D6. Лекарственные средства, которые ингибируют или индуцируют активность CYP2D6, могут влиять на плазменную концентрацию метопролола. \u003Cbr\u003E\nИнгибиторы CYP2D6 (некоторые антидепрессанты и нейролептики, хинидин, тербинафин, целекоксиб, пропафенон, дифенгидрамин, гидроксихлорин, циметидин) повышают концентрацию метопролола в плазме крови. \u003Cbr\u003E\nИндукторы CYP2D6 (производные барбитуровой кислоты, рифампицин) снижают концентрацию метопролола в плазме крови.\u003Cbr\u003E\nОдновременный прием метопролола с сердечными гликозидами, клонидином, блокаторами медленных кальциевых каналов (верапамил, дилтиазем), амиодароном, антиаритмическими средствами I класса, средствами для общей анестезии, метилдопой, гуанфацином может привести к снижению АД и выраженной брадикардии.\u003Cbr\u003E\nСредства для ингаляционного наркоза (производные углеводородов) при одновременном применении с метопрололом повышают риск угнетения функции миокарда и развития артериальной гипотензии.\nОдновременное в/в введение верапамила может спровоцировать остановку сердца.\u003Cbr\u003E\nНПВС и бета-адреномиметики ослабляют антигипертензивный эффект бета-адреноблокаторов.\u003Cbr\u003E\nАлкалоиды спорыньи при одновременном применении с метопрололом повышают риск нарушений периферического кровообращения.\u003Cbr\u003E\nПри совместном приеме метопролола с пероральными гипогликемическими препаратами возможно снижение их эффекта; с инсулином - повышение риска развития гипогликемии, удлинение и усиление ее выраженности, маскировка некоторых симптомов гипогликемии (тахикардия, потливость, повышение АД).\u003Cbr\u003E\nМетопролол снижает клиренс ксантинов (кроме диафиллина), особенно у больных с исходно повышенным клиренсом теофиллина под влиянием курения.\u003Cbr\u003E\nМетопролол снижает клиренс лидокаина, повышает концентрацию лидокаина в плазме.\u003Cbr\u003E\nМетопролол усиливает и пролонгирует действие недеполяризующих миорелаксантов; удлиняет антикоагулянтный эффект кумаринов.\u003Cbr\u003E\nПри одновременном приеме эпинефрина (адреналина) с бета-адреноблокаторами возможно повышение АД и брадикардия.\u003Cbr\u003E\nФенилпропаноламин (норэфедрин) при одновременном применении с метопрололом может повышать диастолическое АД. \u003Cbr\u003E\nАллергены, используемые для иммунотерапии, или экстракты аллергенов для кожных проб при совместном применении с метопрололом повышают риск возникновения системных аллергических реакций или анафилаксии.\u003Cbr\u003E\nЙодсодержащие рентгеноконтрастные средства для в/в введения при совместном применении с метопрололом повышают риск развития анафилактических реакций.\u003Cbr\u003E\nПри совместном применении метопролола с этанолом увеличивается риск выраженного снижения АД."},{"name":"Регистрационный номер","value":"ЛП-000570"},{"name":"Дата государственной регистрации","value":"13.12.2016"},{"name":"Владелец регистрационного удостоверения","value":"АКРИХИН","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["34324371:35649313","7893318:11037214"]}}},{"name":"Изготовитель","value":"АКРИХИН"},{"name":"Фасовщик","value":"АКРИХИН"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Метопролол ретард-Акрихин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-serdtsa-i-sosudov","categoryId":"15756887","navnodeId":"72494","glfilters":["17796364:17998908"]}}},{"name":"Срок годности","value":"24 мес."}]}},"fullSpecsGrouped":{"17188644763695072044":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кровеносные сосуды, сердце"},{"name":"Назначение","value":"артериальная гипертензия, наджелудочковая тахикардия, нарушение ритма сердца, профилактика приступов мигрени, стенокардия, функциональные нарушения сердечной деятельности, сопровождающиеся тахикардией, хроническая сердечная недостаточность"},{"name":"Показания к применению","value":"- артериальная гипертензия;\u003Cbr\u003E- стенокардия;\u003Cbr\u003E- стабильная симптоматическая хроническая сердечная недостаточность с нарушением систолической функции левого желудочка (в качестве вспомогательной терапии к основному лечению хронической сердечной недостаточности);\u003Cbr\u003E- снижение смертности и частоты повторного инфаркта миокарда после острой фазы инфаркта миокарда;\u003Cbr\u003E- нарушения сердечного ритма, включая наджелудочковую тахикардию, снижение частоты сокращения желудочков при фибрилляции предсердий и желудочковых экстрасистолах;\u003Cbr\u003E- функциональные нарушения сердечной деятельности, сопровождающиеся тахикардией;\u003Cbr\u003E- профилактика приступов мигрени."},{"name":"Противопоказания","value":"повышенная чувствительность к метопрололу и другим бета-адреноблокаторам, кардиогенный шок, AV блокада II-III степени, синоатриальная блокада, синдром слабости синусового узла, выраженная брадикардия (ЧСС менее 50 уд/мин), острая сердечная недостаточность или ХСН в стадии декомпенсации, артериальная гипотензия (систолическое АД менее 90 мм рт. ст.), острый инфаркт миокарда (ЧСС менее 45 уд/мин, интервал PQ более 0,24 с, систолическое АД менее 100 мм рт. ст.), период грудного вскармливания, одновременный прием ингибиторов моноаминоксидазы (МАО) или одновременное в/в введение верапамила, феохромоцитома (без одновременного приема альфа-адреноблокаторов), возраст до 18 лет (эффективность и безопасность не установлены), дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция, тяжелая бронхиальная астма, тяжелые нарушения периферического кровообращения."},{"name":"Состав","value":"Одна таблетка содержит:\u003Cbr\u003Eдействующее вещество: метопролола сукцинат 23,83 мг, 47,66 мг и 95,32 мг, что эквивалентно 25 мг, 50 мг и 100 мг метопролола тартрата соответственно;\u003Cbr\u003Eвспомогательные вещества: гипромеллоза 155,96 мг, 161,92 мг и 184,84 мг; лудипресс ЛЦЕ [лактозы моногидрат 94,7-98,3 %, повидон 3-4 %] 117,21 мг, 87,42 мг или 412,84 мг; кремния диоксид коллоидный 1,5 мг, 1,5 мг или 3,5 мг; магния стеарат 1,5 мг, 1,5 мг или 3,5 мг соответственно.\u003Cbr\u003EСостав оболочки:\u003Cbr\u003EДля таблеток с дозировками 25 мг и 100 мг - готовая смесь \"Опадрай II\" оранжевого цвета (поливиниловый спирт 6 мг или 14 мг, тальк 2,22 мг или 5,18 мг, макрогол 3,03 мг или 7,07 мг, титана диоксид 3,36 мг или 7,84 мг, краситель железа оксид красный 0,009 мг или 0,021 мг, краситель железа оксид желтый 0,378 мг или 0,882 мг, краситель железа оксид черный 0,003 мг или 0,007 мг) 15 мг или 35 мг соответственно.\u003Cbr\u003EДля таблеток с дозировкой 50 мг - готовая смесь \"Опадрай II\" зеленого цвета (поливиниловый спирт 6 мг, тальк 2,22 мг, макрогол 3,03 мг, титана диоксид 2,925 мг, краситель хинолиновый желтый (алюминиевый лак) 0,268 мг, краситель железа оксид черный 0,015 мг, краситель индигокармин (алюминиевый лак) 0,542 мг) 15 мг."},{"name":"Действующее вещество","value":"Метопролол"},{"name":"Способ применения и дозы","value":"Препарат Метопролол ретард-Акрихин принимают внутрь 1 раз/сут. Таблетки рекомендуется принимать утром, не разжевывая, запивая водой. Метопролол ретард-Акрихин можно принимать независимо от приема пищи.\u003Cbr\u003EС целью предотвращения брадикардии дозу подбирают индивидуально и увеличивают постепенно.\u003Cbr\u003EПри артериальной гипертензии и стенокардии начальная доза - 50 мг 1 раз/сут, при недостаточном терапевтическом эффекте суточная доза может быть увеличена до 100-200 мг/сут. При артериальной гипертензии при неэффективности препарата в дозе 100-200 мг/сут можно добавить другое гипотензивное средство.\u003Cbr\u003EПри хронической сердечной недостаточности II функционального класса по классификации NYHA (без обострений последние 6 недель и без изменения в комплексной терапии в течение последних 2 недель) рекомендуемая начальная доза - 25 мг 1 раз/сут. Через 2 недели суточную дозу можно повысить до 50 мг, затем через 2 недели - до 100 мг, еще через 2 недели - до 200 мг.\u003Cbr\u003EПри хронической сердечной недостаточности III-IV функционального класса по классификации NYHA рекомендуемая начальная доза - первые 2 недели 12.5 мг 1 раз/сут. Возможно применение метопролола в другой лекарственной форме, например, таблетки по 25 мг с риской. В период увеличения дозы пациент должен находиться под наблюдением, т.к. у некоторых пациентов симптомы сердечной недостаточности могут ухудшиться.\u003Cbr\u003EЧерез 1-2 недели доза может быть увеличена до 25 мг 1 раз/сут. Затем через 2 недели доза может быть увеличена до 50 мг 1 раз/сут. Пациентам, которые хорошо переносят препарат, можно удваивать дозу каждые 2 недели до достижения максимальной дозы 200 мг 1 раз/сут.\u003Cbr\u003EПри вторичной профилактике инфаркта миокарда и нарушений сердечного ритма начальная доза составляет 100 мг 1 раз/сут.\u003Cbr\u003EПри функциональных нарушениях сердечной деятельности, сопровождающихся тахикардией, назначают по 50 мг/сут, при необходимости дозу можно увеличить до 200 мг/сут. \u003Cbr\u003EДля профилактики приступов мигрени назначают по 100-200 мг 1 раз/сут.\u003Cbr\u003EПациентам пожилого возраста, пациентам с почечной недостаточностью или пациентам, находящимся на гемодиализе, коррекции дозы не требуется.\u003Cbr\u003EНарушения функции печени влияют на выведение метопролола, поэтому может потребоваться коррекция дозы в зависимости от клинического состояния.\u003Cbr\u003E"},{"name":"Побочные действия","value":"Частота побочных эффектов: очень часто - более 1/10, часто - более 1/100 и менее 1/10, нечасто - более 1/1000 и менее 1/100, редко - более 1/10000 и менее 1/1000, очень редко - менее 1/10000, включая отдельные сообщения.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: часто - брадикардия, ортостатическая гипотензия (в т.ч. с обмороком), похолодание нижних конечностей, ощущение сердцебиения; нечасто - временное усиление симптомов сердечной недостаточности, кардиогенный шок у пациентов с инфарктом миокарда, AV блокада I степени; редко - нарушения проводимости миокарда, аритмия; очень редко - гангрена (у пациентов с нарушениями периферического кровообращения).\u003Cbr\u003EСо стороны центральной нервной системы: очень часто - повышенная утомляемость, снижение скорости психических и двигательных реакций; часто - головокружение, головная боль; нечасто - парестезии, судороги, депрессия, снижение концентрации внимания, сонливость, бессонница, \"кошмарные\" сновидения; редко - астения, тремор, повышенная нервная возбудимость, тревога; очень редко - амнезия/нарушение памяти, подавленность, галлюцинации, миастения.\u003Cbr\u003EСо стороны органов чувств: редко - нарушение зрения, сухость и/или раздражение глаз, конъюнктивит; очень редко - звон в ушах, нарушение вкусовых ощущений.\u003Cbr\u003EСо стороны пищеварительной системы: часто - тошнота, боль в животе, запор или диарея; нечасто - рвота; редко - сухость слизистой оболочки полости рта, нарушение функции печени, гепатит.\u003Cbr\u003EСо стороны кожных покровов: нечасто - крапивница, усиление потоотделения; редко - алопеция; очень редко - фотосенсибилизация, обострение течения псориаза, псориазоподобные кожные реакции.\u003Cbr\u003EСо стороны дыхательной системы: часто - одышка; нечасто - бронхоспазм у пациентов с бронхиальной астмой; редко - ринит.\u003Cbr\u003EЛабораторные показатели: очень редко - тромбоцитопения (необычные кровотечения и кровоизлияния), агранулоцитоз, лейкопения, повышение активности \"печеночных\" ферментов, гипербилирубинемия.\u003Cbr\u003EСо стороны эндокринной системы: часто - гипогликемия (у пациентов с сахарным диабетом I типа), редко - гипергликемия (у пациентов с сахарным диабетом II типа), гипотиреоидное состояние.\u003Cbr\u003EПрочие: нечасто - увеличение массы тела; редко - импотенция/сексуальная дисфункция; очень редко - артралгия, тромбоцитопения."},{"name":"Фармакологическое действие","value":"Кардиоселективный бета1-адреноблокатор. Не оказывает мембраностабилизирующего действия и не обладает внутренней симпатомиметической активностью. Обладает антигипертензивным, антиангинальным и антиаритмическим действием.\u003Cbr\u003EБлокируя в невысоких дозах бета1-адренорецепторы сердца, уменьшает стимулированное катехоламинами образование циклического аденозинмонофосфата (цАМФ) из аденозинтрифосфата (АТФ), снижает внутриклеточный ток ионов кальция, оказывает отрицательное хроно-, дромо-, батмо- и инотропное действие (урежает частоту сердечных сокращений (ЧСС), угнетает проводимость и возбудимость, снижает сократимость миокарда).\u003Cbr\u003EОбщее периферическое сосудистое сопротивление (ОПСС) в начале применения бета-адреноблокаторов (в первые 24 ч после перорального приема) увеличивается (в результате реципрокного возрастания активности альфа-адренорецепторов и устранения стимуляции бета2-адренорецепторов), которое через 1-3 дня возвращается к исходному, а при длительном назначении снижается.\u003Cbr\u003EАнтигипертензивное действие обусловлено уменьшением минутного объема кровотока и синтеза ренина, угнетением активности ренин-ангиотензин-альдостероновой системы (имеет большее значение у пациентов с исходной гиперсекрецией ренина) и центральной нервной системы, восстановлением чувствительности барорецепторов дуги аорты (не происходит усиления их активности в ответ на снижение артериального давления (АД) и в итоге уменьшением периферических симпатических влияний. Снижает повышенное АД в покое, при физическом напряжении и стрессе. Антигипертензивный эффект длится более 24 часов.\u003Cbr\u003EАнтиангинальный эффект определяется снижением потребности миокарда в кислороде в результате уменьшения ЧСС (удлинение диастолы и улучшение перфузии миокарда) и сократимости, а также снижением чувствительности миокарда к воздействию симпатической иннервации.\u003Cbr\u003EУменьшает число и тяжесть приступов стенокардии и повышает переносимость физической нагрузки. За счет повышения конечного диастолического давления в левом желудочке и увеличения растяжения мышечных волокон желудочков может повышать потребность в кислороде, особенно у пациентов с хронической сердечной недостаточностью (ХСН).\u003Cbr\u003EАнтиаритмический эффект обусловлен устранением аритмогенных факторов (тахикардии, повышенной активности симпатической нервной системы, увеличенного содержания цАМФ, артериальной гипертензии), уменьшением скорости спонтанного возбуждения синусного и эктопического водителей ритма и замедлением атриовентрикулярного (AV) проведения (преимущественно в антеградном и в меньшей степени в ретроградном направлениях через AV узел) и по дополнительным путям.\u003Cbr\u003EПри суправентрикулярной тахикардии, мерцании предсердий, синусовой тахикардии при функциональных заболеваниях сердца и тиреотоксикозе урежает ЧСС или даже может привести к восстановлению синусного ритма.\u003Cbr\u003EПредупреждает развитие мигрени.\u003Cbr\u003EВ отличие от неселективных бета-адреноблокаторов при назначении в средних терапевтических дозах оказывает менее выраженное влияние на органы, содержащие бета2-адренорецепторы (поджелудочная железа, скелетные мышцы, гладкая мускулатура периферических артерий, бронхов и матки) и на углеводный обмен; выраженность атерогенного действия не отличается от действия пропранолола.\u003Cbr\u003EПри многолетнем приеме снижает концентрацию холестерина в крови. При применении в больших дозах (более 100 мг/сут) оказывает блокирующий эффект на оба подтипа бета-адренорецепторов."},{"name":"Фармакологическая группа","value":"бета1-адреноблокатор селективный"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Токсичность: метопролол в дозе 7,5 г у взрослого вызвал интоксикацию с летальным исходом. У 5-ти летнего ребенка, принявшего 100 мг метопролола, после промывания желудка не отмечалось признаков интоксикации. Прием 450 мг метопролола подростком 12 лет привел к умеренной интоксикации. Прием 1,4 г и 2,5 г метопролола взрослыми вызвал умеренную и тяжелую интоксикацию, соответственно. Прием 7,5 г взрослым привел к крайне тяжелой интоксикации.\u003Cbr\u003EСимптомы: выраженная брадикардия, AV блокада (вплоть до развития полной поперечной блокады и остановки сердца), выраженное снижение АД, нарушение периферического кровообращения, усиление симптомов сердечной недостаточности, кардиогенный шок, угнетение дыхания, апноэ, цианоз, повышенная утомляемость, головокружение, потеря сознания, кома, тремор, судороги, повышение потоотделения, парестезии, бронхоспазм, тошнота, рвота, возможно развитие эзофагоспазма, гипогликемия или гипергликемия, гиперкалиемия, преходящая миастения. Первые признаки передозировки проявляются через 20 мин-2 ч после приема препарата.\u003Cbr\u003EЛечение: Если препарат принят недавно - промывание желудка и прием адсорбирующих средств; Атропин (0,25-0,5 мг в/в для взрослых, 10-20 мкг/кг для детей) должен быть назначен до промывания желудка (риск стимуляции блуждающего нерва). При нарушении атриовентрикулярной проводимости и/или брадикардии - в/в введение 1-2 мг атропина, эпинефрина (адреналина) или постановка временного кардиостимулятора; при снижении артериального давления - пациент должен находиться в положении Тренделенбурга. Если нет признаков отека легких - в/в плазмозамещающие растворы, при неэффективности - введение эпинефрина, допамина, добутамина. Можно также применять глюкагон 50-150 мкг/кг в/в с интервалом в 1 минуту (оказывает положительное инотропное и хронотропное действие на миокард); при острой сердечной недостаточности - сердечные гликозиды, диуретики; при судорогах - в/в диазепам; при бронхоспазме - ингаляционно или парентерально бета2-адреномиметики."},{"name":"Применение при беременности и кормлении грудью","value":"Как и большинство бета-адреноблокаторов, препарат Метопролол ретард-Акрихин не следует применять при беременности и в период грудного вскармливания, за исключением тех случаев, когда ожидаемая польза для матери превышает потенциальный риск для плода и/или ребенка. Как и другие гипотензивные средства, бета-адреноблокаторы могут вызывать побочные эффекты, например, брадикардию у плода, новорожденных или детей, находящихся на грудном вскармливании.\u003Cbr\u003EКоличество метопролола, которое проникает в грудное молоко, и бета-адреноблокирующее действие метопролола у ребенка, находящегося на грудном вскармливании (при приеме матерью метопролола в терапевтических дозах), являются незначительными. Рекомендуется следить за появлением признаков блокады бета-адренергических рецепторов у грудных детей (в случае, если кормящая мать получает терапию препаратом)."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Контроль больных, принимающих бета-адреноблокаторы, включает регулярное наблюдение за ЧСС и АД. Следует обучить больного методике подсчета ЧСС и проинструктировать о необходимости врачебной консультации при ЧСС менее 50 уд./мин.\u003Cbr\u003EВозможно усиление выраженности аллергических реакций (на фоне отягощенного аллергологического анамнеза) и отсутствие эффекта от введения обычных доз эпинефрина (адреналина).\u003Cbr\u003EУ пожилых пациентов рекомендуется осуществлять контроль функции почек (1 раз в 4-5 мес). \u003Cbr\u003EПрием препарата Метопролол ретард-Акрихин может усилить симптомы нарушения периферического артериального кровообращения.\u003Cbr\u003EПри стенокардии напряжения подобранная доза препарата должна обеспечивать ЧСС в покое в пределах 55-60 уд./мин, при нагрузке - не более 110 уд./мин. \u003Cbr\u003EУ курящих пациентов эффективность бета-адреноблокаторов ниже.\u003Cbr\u003EМетопролол ретард-Акрихин может маскировать некоторые клинические проявления тиреотоксикоза (например, тахикардию). Резкая отмена препарата у больных с тиреотоксикозом противопоказана, поскольку способна усилить симптоматику.\u003Cbr\u003EПри сахарном диабете прием препарата Метопролол ретард-Акрихин может маскировать тахикардию, вызванную гипогликемией. \u003Cbr\u003EПри необходимости назначения пациентам с бронхиальной астмой в качестве сопутствующей терапии используют бета2-адреномиметики; при феохромоцитоме - альфа-адреноблокаторы.\u003Cbr\u003EПри необходимости проведения хирургического вмешательства необходимо предупредить врача-анестезиолога о приеме препарата Метопролол ретард-Акрихин (необходим выбор средства для общей анестезии с минимальным отрицательным инотропным действием), отмена препарата не рекомендуется.\u003Cbr\u003EРеципрокную активацию блуждающего нерва можно устранить в/в введением атропина (1-2 мг).\u003Cbr\u003EВ случае появления нарастающей брадикардии (менее 50 уд/мин), артериальной гипотензии (систолическое АД ниже 100 мм рт.ст.), AV-блокады, бронхоспазма, желудочковых аритмий, тяжелых нарушений функции печени и почек необходимо уменьшить дозу или прекратить лечение.\u003Cbr\u003EРекомендуется прекращать терапию при появлении кожных высыпаний и развитии депрессии, вызванной приемом бета-адреноблокаторов.\u003Cbr\u003EПри резкой отмене клонидина может резко повышаться АД, при одновременном приеме бета-адреноблокаторов. В случае отмены клонидина, прекращение приема бета-адреноблокаторов следует начинать за несколько дней до отмены клонидина. \u003Cbr\u003EПрепараты, снижающие запасы катехоламинов (например, резерпин), могут усилить действие бета-адреноблокаторов, поэтому пациенты, принимающие такие сочетания препаратов, должны находиться под постоянным медицинским наблюдением на предмет выявления чрезмерного снижения АД или брадикардии.\u003Cbr\u003EПри резком прекращении лечения может возникнуть синдром отмены (усиление приступов стенокардии, повышение АД). Особое внимание при отмене препарата необходимо уделять больным стенокардией, хронической сердечной недостаточностью, после перенесенного инфаркта миокарда. Отмену препарата Метопролол ретард-Акрихин проводят постепенно, сокращая дозу в течение 10 дней. \u003Cbr\u003EПациенты, пользующиеся контактными линзами, должны учитывать, что на фоне лечения бета-адреноблокаторами возможно уменьшение продукции слезной жидкости."},{"name":"Взаимодействие","value":"Средства, снижающие запасы катехоламинов, (например, резерпин, ингибиторы МАО) при одновременном применении с метопрололом могут усилить гипотензивное действие или вызвать выраженную брадикардию. Перерыв в лечении между приемом ингибиторов МАО и метопролола должен составлять не менее 14 дней.\u003Cbr\u003E\nМетопролол является субстратом изофермента CYP2D6. Лекарственные средства, которые ингибируют или индуцируют активность CYP2D6, могут влиять на плазменную концентрацию метопролола. \u003Cbr\u003E\nИнгибиторы CYP2D6 (некоторые антидепрессанты и нейролептики, хинидин, тербинафин, целекоксиб, пропафенон, дифенгидрамин, гидроксихлорин, циметидин) повышают концентрацию метопролола в плазме крови. \u003Cbr\u003E\nИндукторы CYP2D6 (производные барбитуровой кислоты, рифампицин) снижают концентрацию метопролола в плазме крови.\u003Cbr\u003E\nОдновременный прием метопролола с сердечными гликозидами, клонидином, блокаторами медленных кальциевых каналов (верапамил, дилтиазем), амиодароном, антиаритмическими средствами I класса, средствами для общей анестезии, метилдопой, гуанфацином может привести к снижению АД и выраженной брадикардии.\u003Cbr\u003E\nСредства для ингаляционного наркоза (производные углеводородов) при одновременном применении с метопрололом повышают риск угнетения функции миокарда и развития артериальной гипотензии.\nОдновременное в/в введение верапамила может спровоцировать остановку сердца.\u003Cbr\u003E\nНПВС и бета-адреномиметики ослабляют антигипертензивный эффект бета-адреноблокаторов.\u003Cbr\u003E\nАлкалоиды спорыньи при одновременном применении с метопрололом повышают риск нарушений периферического кровообращения.\u003Cbr\u003E\nПри совместном приеме метопролола с пероральными гипогликемическими препаратами возможно снижение их эффекта; с инсулином - повышение риска развития гипогликемии, удлинение и усиление ее выраженности, маскировка некоторых симптомов гипогликемии (тахикардия, потливость, повышение АД).\u003Cbr\u003E\nМетопролол снижает клиренс ксантинов (кроме диафиллина), особенно у больных с исходно повышенным клиренсом теофиллина под влиянием курения.\u003Cbr\u003E\nМетопролол снижает клиренс лидокаина, повышает концентрацию лидокаина в плазме.\u003Cbr\u003E\nМетопролол усиливает и пролонгирует действие недеполяризующих миорелаксантов; удлиняет антикоагулянтный эффект кумаринов.\u003Cbr\u003E\nПри одновременном приеме эпинефрина (адреналина) с бета-адреноблокаторами возможно повышение АД и брадикардия.\u003Cbr\u003E\nФенилпропаноламин (норэфедрин) при одновременном применении с метопрололом может повышать диастолическое АД. \u003Cbr\u003E\nАллергены, используемые для иммунотерапии, или экстракты аллергенов для кожных проб при совместном применении с метопрололом повышают риск возникновения системных аллергических реакций или анафилаксии.\u003Cbr\u003E\nЙодсодержащие рентгеноконтрастные средства для в/в введения при совместном применении с метопрололом повышают риск развития анафилактических реакций.\u003Cbr\u003E\nПри совместном применении метопролола с этанолом увеличивается риск выраженного снижения АД."},{"name":"Регистрационный номер","value":"ЛП-000570"},{"name":"Дата государственной регистрации","value":"13.12.2016"},{"name":"Владелец регистрационного удостоверения","value":"АКРИХИН"},{"name":"Изготовитель","value":"АКРИХИН"},{"name":"Фасовщик","value":"АКРИХИН"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Метопролол ретард-Акрихин"},{"name":"Срок годности","value":"24 мес."}]}],"transitionId":"tr_111237645114258585"}}}}
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    Цена 76 ₽
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  • Метопролол таб., 25 мг, 60 шт.
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    Метопролол таб., 25 мг, 60 шт.

    Рейтинг товара: 4.8 из 5
    на основе 9 оценок
    Цена 70 ₽
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  • Метопролол-акрихин таб., 50 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fnos7srkai/toggleWishlist":{"skuId":"228004260","productId":1778173671,"offerId":"Ke6AQlLZS4aMD7H4rl9rWg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvqz44/+y16FNEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI543zzwYQpKPcbBie1KEFINfcwQc=","sign":"vKlrSYBKZG0UgxRz1tMKaVfzT9SgbBILv4QZd8Z/FUE="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fnos7srkai/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метопролол-акрихин таб., 50 мг, 60 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 172 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fnos7srkai/addToCartButton":{"offerId":"Ke6AQlLZS4aMD7H4rl9rWg","skuId":"228004260","pendingCartItem":{"productId":1778173671,"offerId":"Ke6AQlLZS4aMD7H4rl9rWg","showPlaceId":"OTNDnItfwRMjN9MRHuEMMmhPhP22dfm_aLK5AXIdcpmt6Teze8J3p2UpXkD6jJ4YQ9riLTqyFsFODMXSPFufPI_nEOAe9v-M_xZ3ujDWbzHSgytWDH-ENGj4awQlifz9kSiDo3r6iaCUhyEp73EZ-TVixiUgNaNCXskDh1kdf5GQrVryqsuoteN_jGjmFV2LU7M7PYGX1OndZuIkx5TMiw,,","feeShow":"OTNDnItfwRMjN9MRHuEMMmhPhP22dfm_aLK5AXIdcpmt6Teze8J3p2UpXkD6jJ4YQ9riLTqyFsFODMXSPFufPI_nEOAe9v-M_xZ3ujDWbzHSgytWDH-ENGj4awQlifz9kSiDo3r6iaCUhyEp73EZ-TVixiUgNaNCXskDh1kdf5GQrVryqsuoteN_jGjmFV2LU7M7PYGX1OndZuIkx5TMiw,,","skuId":"228004260","shopId":77075781,"price":{"applicablePriceDiscounts":[],"value":"172","currency":"RUR"},"hid":"15756887","name":"Метопролол-акрихин таб., 50 мг, 60 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  • Метопролол таб. пролонг. высвоб. п/о плен., 25 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fzfngyjl07v/toggleWishlist":{"skuId":"101454666851","productId":1401075932,"offerId":"ZxYrF6aMQy0Ip2IooF2UaA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvqz44/+y16FNEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI3PGKnAUQ47it+fkCGLTVhwQg19zBBw==","sign":"ay1nh7kqK1F6WIfUTkRW0hT+iDi4vUoT88vZ0diPfIA="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fzfngyjl07v/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метопролол таб. пролонг. высвоб. п/о плен., 25 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 10 оценок
    Цена 138 ₽
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  • Метопролол-Акрихин таб., 50 мг, 30 шт.
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    Метопролол-Акрихин таб., 50 мг, 30 шт.

    Рейтинг товара: 3 из 5
    на основе 2 оценки
    Цена 90 ₽
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  • Эгилок таб., 25 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-tjqf20er7pg/toggleWishlist":{"skuId":"227814603","productId":1401075630,"offerId":"sR7D5jAQBihSmDEFS-X4Yw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvqz44/+y16FNEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIru+KnAUQy9nQbBiS3dAHINfcwQc=","sign":"vYlLZp2As+d+xZdOqV2w6IORM+60BEIKOWqXNiijeUg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-tjqf20er7pg/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эгилок таб., 25 мг, 60 шт.

    Рейтинг товара: 4.9 из 5
    на основе 12 оценок
    Цена 79 ₽
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-tjqf20er7pg/addToCartButton":{"offerId":"sR7D5jAQBihSmDEFS-X4Yw","skuId":"227814603","pendingCartItem":{"productId":1401075630,"offerId":"sR7D5jAQBihSmDEFS-X4Yw","showPlaceId":"OTNDnItfwRMjN9MRHuEMMmhPhP22dfm_SNfEF-KWNSzs6Pi4IkzWDd9YqBOxMoWgQM2qSJgNesU_0v2sMpvj0X8Qc0tHp0eCPhrzlswQOjAEN81COZS9pvE3NiqFPZFJ1K3B98bqyQ3rXjIUojFMYdPcS4Afx2BnCcO3uzOS2UNO9bQM4d7DaBipoL3Uh_TgXxUZc2uLanJmRhlsXT_onw,,","feeShow":"OTNDnItfwRMjN9MRHuEMMmhPhP22dfm_SNfEF-KWNSzs6Pi4IkzWDd9YqBOxMoWgQM2qSJgNesU_0v2sMpvj0X8Qc0tHp0eCPhrzlswQOjAEN81COZS9pvE3NiqFPZFJ1K3B98bqyQ3rXjIUojFMYdPcS4Afx2BnCcO3uzOS2UNO9bQM4d7DaBipoL3Uh_TgXxUZc2uLanJmRhlsXT_onw,,","skuId":"227814603","shopId":55106433,"price":{"applicablePriceDiscounts":[],"value":"79","currency":"RUR"},"hid":"15756887","name":"Эгилок таб., 25 мг, 60 шт.","label":"8abdss1r2pd","count":0,"features":[],"imageMeta":{"namespace":"mpic","groupId":1514097,"key":"img_id2148949371878906087.jpeg"}},"quantity":{"step":1,"minimum":1,"maximum":999},"cpaUrl":"/safeclick/data=TxNGOK9vJEN7oLFLeCTKEixJYuEMI0EzvZFs82AjjgjhTwweZ7mRXd_AQ0K184sfZmy5nQz7U8xIc-qdVOMFoxnoSww2ObzLEs1KJpltGipDSanCui6QCo8GXRHxAQaqQQZbzp5kb0bdQDXqQiIIDEwL4INEBUjrbUNtjxqZ96WFVmZtSFtMyb3yJJ0vvI_f_VoLwr8_fQDSzGtzWieo5034SbicIgx0aRbUDt3Utb0GGORtVWyDf00DS9UqxUVy3KHcWRnbme4i9q9VI21D3BD2o9DZLShTUxAZ6a2OnsxSlrVDejygifQnqhz6gk39RVpaCr-nNWs_GNc9sONc4-bLOgCIFKc6O33hyrxmBy2jbGMPWdJPleO4gFakuftbaE-fD7BUQhj6yit0sf8nNCrLLrdi382YmV6lTqyFbxVcFEs0XO5xClVvcasO81FR0n75DOTKPbhXGlIphkquqPKDrgUlzxL5ZJya_OnCquYJK_rHxV4k6CxEiTEBIK2z9-Fz5JSLGNQN2nToPXEZXz4b1jx9PNmZLpbCca5B4_sD-1Q9DlVzFjVfIn9oCh7vZPBr1R7RTzXv1FoG_zytwks1xdOS_-zKOqfVV8nnd7--FVM-OfJCFci6GDOYeSqXrpr1BTxZ5u4n2Zxs_UadArMBTpI32Zb7e1XKqgC-AKLAS4P9zoXB0lKDURm1Xq4b86UbMs-BU2JCGcGdfOEGHcJLEOymFn7xVmO5lbf1OTuQRYC5Lh9Xy_BKbl0zK4HS6m73d_bUklZAkP6YUFjGxCQkBgZwvfyWfJ-x9z0JhIxJiAD8Rxhd7QmdqOo47FmVdqFo6J9hx23JHR7z4X54quHLBjYHI-9gXtogt2sHKVcX14MNZuVJidGHjC_ODchcoiAAg1uU7-8L3I6s6nE6ZfLHIllkHmwPzZM3U7ho_c7hu_1zsAv57_3jx5nFhyQyTArNwc7xwX5snNjkj6pOqtnK5uO9wSrm5frjTaqX261GsPOLYiHHv-O1ebZTHPQoPuoRFixA1f0LfBDMuKwm4lpstdA_7E-fq4xxJRF9zQ4zy1yYFMvBDHQCzTfc_tkLlO3cgoXBvrLslx1vnZ98Fmxve3L0Wjmad7NRj2_yYbt3GTbkixQaTYARsIe6p9YAoolbROaIFO9RROKpqASa8PXOj2xdam9gbc0vRCnFlxFeT-1fy67HiSbTd0kLt9Zp__sn_h5Oo3AuT1xA1nv5xajlzfx5IIPnkWOH2OAxnFXahZjrQ0fVtvHgY76R3zaxFBAHz-9rUeK7hTkl3Dw2SKP2YijAPQm5h3372uuLJE6cR_wYAPRAZCVOb4mkdIAn0COIPisso5ZcWMRAQEiZrNSTjPuNKhXgOa9qVgARZjGZv7mwlcC1-tw5XySSdQsgbGev403LxUrIibqyLoDgrE-PvhtbjlgZi1u591H_YM_QZFF8dCmuOWdqFZacjbx-YQzw7bxZ9dS07wqav49XtEV-2tSwMTahYhZHfhB_gOLKGPnNxgzAM2QgwNT2A3B7wWQdsxUKWWAMKffFCddErcdCawOxaIOCsYdf5LCuXPqSn_ZT0aYa1Y5DIdBzfb0fXzq_8xC4JLkyJeMIIcRgjqz1njYwrg1YocnQR5CJgBSf87ktyGwEmNY1V_J0cZvWRoN67erN9a6--QX7dpV7PFtUMSxg4ZafyWE1cr3f3LGGG0CwS9i8QF8tamZa9njPmTkSXvKNO_RrSNWEmsIQFr5LmRFmlTvwYu6raZ7SunT59pdBqLECCXg5JIduM1_Ha0P5OpsJN-TrMC-4deLdZgncBT7f1U328G2Jri6cs_Z4yXs_J78X_yEbHELTpxmBcnWtCahhSFYEQefAelZsdYCcUUG-JTu-i3P2Xh9guZENYBX4qIxnLzSmT7G2GSJw7REjDt_Zwxg-LaD5Nyto_5yHiRJjDWn9eV5Ts91UfWfVTB7pkT7vcBJkGqKjlfiJi4pSrHQ1BvQ5mbwJsCy8f3NkBHgl3R3xwwpcBgweXKkYeDl2X5bVbCIUAllNXHJCQJucF7yEFBIuSsxBTLGsz-mrw73mygsmaXy33uwpBNwqu3I3OHeiKbVc5iXDMXpkRuhWmDthgOtgnZrc1CX3-f_8G52eKDXHhyMzOECOYBFmWA3gplXdFLHLR91WN4_l253-4fGg_s7kozcKUIcksarUmd21UESQqEVimOSKG-LGekz_IG2rusz8x_G6l5Y5auqfDg0jjV5460boCATJPFdVDPgF-SZhmw2z6R9D4NSvHVU4NzlqAvYW4_DLew-8o6uvZMU7tZpu66J-YJARJuyUwjF2E1_nbUtG7FODp-n-Pu9gvjtrrjhi49yUgk20QTWG0xzv6Fn3A8pSycgZSRal96Diza-t8lNx9H2vGqg9tMz6oQtHPnXnDU8UFgE6fqSIY-DjEKBmvlniCUONNGi7S5G-mzMBF-ZLsdR5tjQLbzBeqlXNNZCg5-9Rw6I395JAbAvPu_gABZ5001Bgn0JeYvtvsGbiNw2t3N0LXfmEXF1ymXxSZ9rBzqvAjNuPg3G-YxEAEHtPwF7LLtoyVaczGEtqtQmz2991x2NAN-GlUPjwp0um6dSav6Lmqi87poFd6Jlw7CZv0ImIsI6tAPua-XC8z0caII_LQb4r3FSyKhGfu53JWHnNAXbgyQuAMMdMomca6QEACnU1_ZUhFOtSGGE418OdcJ-g2q-OORzNIofffcQx_KKa5zoPiglk7EqLuobED6krPNmhKyXr1ESxDYg6o6t7y82IJJw31_R2SXFf5YbvCjSXrCK4gU_Ojayk0XVdH1mp_VxU_Ycnc8XTKuM7pBBMqo46pKqlE1Fe3knkqdjGAtEOWBomT70gzCudmRDlWHPw8OO104UX6GNGeZEnnziQ1WqhobTXhlo7AB0T8PDYH-Hg9OxwPX0HD1lVgIIV8pZpw5zKFCAc8YaeDWwMaKrvnUS_pOYP4tpGH2ssFHCADpsVS9NkBoMgLJqsAsG0sRtwVelLmEppJGKYKdbnR6wDUSDWrb1uE0Hq7OhWbv_QgX19buY-qr-rtDbSn6drovf5Dax6ESmfkZXPdlhXT5UoV7_2dNz2N97YYk9RFWy4CEjVSw_LrUKkxH0UFNZzpRlxD6Um7yAFphviTDIDQP6ilAowRAmiuj2cwW9rL7CGdrAzVZL9gkovzv9hlYqBjRRyyIIti_xZeWUxFg3g5dXYUepRWXNexUkFMBIal_n4rudFXy0rLUAvMFtiXTasY-UHEN5HVdgW3WdbZ7FNvBU3UxoZejfLqsifb_16wB65RGjwI56YoIHNL0sfGI5c4osB8_Br8GKLvRr3o-dzTuRUQ6NFuHz6C_GrmotK0rGc5m060UR1O3shu-z9km8zox64YGVmJhqIbCyeDqcVL-zzyhNGENeSGTwLitTUkNrQh4OcwBo8P2z9Eg8L2HIbG2RPiCOELsv61Kc13sGtUYszW6Bq1iiy4z_24n8JrxqsCqTGJTCGr2tDc8WYuYOJGzGqZ61OSV7pw3n7JyUhHVUqBvIG-1Uf6rI7cGPa78qm3Q,,/b64e=1/sign=0fdcd162268b942791c434b892cbc785/keyno=MARKET_1/*","showUid":"17176315512411437895606006","cartLink":"/my/cart","showNotificationWhenDeleteItem":true,"isLavka":false,"isError":false,"isEats":false,"isCR":false,"isM2bEdoOnlyEnable":false,"isEatsMarketIntegration":true,"isCartButtonNext":false,"isUpsalePopupCRExp":false,"baobabClientDataAdditionToCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvqz44/+y16FNEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIru+KnAUQy9nQbBiS3dAHINfcwQc=","sign":"vYlLZp2As+d+xZdOqV2w6IORM+60BEIKOWqXNiijeUg="},"target":"cart_addition"},"baobabClientDataDeletionFromCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvqz44/+y16FNEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIru+KnAUQy9nQbBiS3dAHINfcwQc=","sign":"vYlLZp2As+d+xZdOqV2w6IORM+60BEIKOWqXNiijeUg="},"target":"cart_deletion"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-tjqf20er7pg/addToCartButton":{"name":"@light/AddToCartButtonSnippet"}}}
  • Метопролол Реневал таб., 50 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-tp56ho1srur/toggleWishlist":{"skuId":"101541597026","productId":1493954584,"offerId":"s7xHYsl4kGILMxZeD7CYZQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvqz44/+y16FNEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcImOCvyAUQ4p7novoCGPKsgggg19zBBw==","sign":"Yksz4FbiFiB+BaUAQx3U903o5bplIOgSaYZy032gHlI="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-tp56ho1srur/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метопролол Реневал таб., 50 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 82 ₽
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  • Метопролол Органика таб., 50 мг, 30 шт.
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    Метопролол Органика таб., 50 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 14 оценок
    Цена 54 ₽
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  • Беталок Зок таб. с замедл. высвоб. п/о, 50 мг, 30 шт.
    –9 %
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    Беталок Зок таб. с замедл. высвоб. п/о, 50 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 43 оценки
    Цена 319 ₽ вместо 351
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  • Карведилол-Акрихин таб., 6.25 мг, 30 шт.
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    Карведилол-Акрихин таб., 6.25 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 6 оценок
    Цена 204 ₽
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  • Клопидогрел-Акрихин таб. п/о плен., 75 мг, 30 шт.
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    Клопидогрел-Акрихин таб. п/о плен., 75 мг, 30 шт.

    Рейтинг товара: 4.7 из 5
    на основе 3 оценки
    Цена 470 ₽
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  • Беталок зок таб. с замедл. высвоб. п/о, 50 мг, 30 шт.
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    Беталок зок таб. с замедл. высвоб. п/о, 50 мг, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 54 оценки
    Цена 296 ₽
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Инструкция

Показания к применению

- артериальная гипертензия;
- стенокардия;
- стабильная симптоматическая хроническая сердечная недостаточность с нарушением систолической функции левого желудочка (в качестве вспомогательной терапии к основному лечению хронической сердечной недостаточности);
- снижение смертности и частоты повторного инфаркта миокарда после острой фазы инфаркта миокарда;
- нарушения сердечного ритма, включая наджелудочковую тахикардию, снижение частоты сокращения желудочков при фибрилляции предсердий и желудочковых экстрасистолах;
- функциональные нарушения сердечной деятельности, сопровождающиеся тахикардией;
- профилактика приступов мигрени.

Противопоказания

повышенная чувствительность к метопрололу и другим бета-адреноблокаторам, кардиогенный шок, AV блокада II-III степени, синоатриальная блокада, синдром слабости синусового узла, выраженная брадикардия (ЧСС менее 50 уд/мин), острая сердечная недостаточность или ХСН в стадии декомпенсации, артериальная гипотензия (систолическое АД менее 90 мм рт. ст.), острый инфаркт миокарда (ЧСС менее 45 уд/мин, интервал PQ более 0,24 с, систолическое АД менее 100 мм рт. ст.), период грудного вскармливания, одновременный прием ингибиторов моноаминоксидазы (МАО) или одновременное в/в введение верапамила, феохромоцитома (без одновременного приема альфа-адреноблокаторов), возраст до 18 лет (эффективность и безопасность не установлены), дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция, тяжелая бронхиальная астма, тяжелые нарушения периферического кровообращения.

Способ применения и дозы

Препарат Метопролол ретард-Акрихин принимают внутрь 1 раз/сут. Таблетки рекомендуется принимать утром, не разжевывая, запивая водой. Метопролол ретард-Акрихин можно принимать независимо от приема пищи.
С целью предотвращения брадикардии дозу подбирают индивидуально и увеличивают постепенно.
При артериальной гипертензии и стенокардии начальная доза - 50 мг 1 раз/сут, при недостаточном терапевтическом эффекте суточная доза может быть увеличена до 100-200 мг/сут. При артериальной гипертензии при неэффективности препарата в дозе 100-200 мг/сут можно добавить другое гипотензивное средство.
При хронической сердечной недостаточности II функционального класса по классификации NYHA (без обострений последние 6 недель и без изменения в комплексной терапии в течение последних 2 недель) рекомендуемая начальная доза - 25 мг 1 раз/сут. Через 2 недели суточную дозу можно повысить до 50 мг, затем через 2 недели - до 100 мг, еще через 2 недели - до 200 мг.
При хронической сердечной недостаточности III-IV функционального класса по классификации NYHA рекомендуемая начальная доза - первые 2 недели 12.5 мг 1 раз/сут. Возможно применение метопролола в другой лекарственной форме, например, таблетки по 25 мг с риской. В период увеличения дозы пациент должен находиться под наблюдением, т.к. у некоторых пациентов симптомы сердечной недостаточности могут ухудшиться.
Через 1-2 недели доза может быть увеличена до 25 мг 1 раз/сут. Затем через 2 недели доза может быть увеличена до 50 мг 1 раз/сут. Пациентам, которые хорошо переносят препарат, можно удваивать дозу каждые 2 недели до достижения максимальной дозы 200 мг 1 раз/сут.
При вторичной профилактике инфаркта миокарда и нарушений сердечного ритма начальная доза составляет 100 мг 1 раз/сут.
При функциональных нарушениях сердечной деятельности, сопровождающихся тахикардией, назначают по 50 мг/сут, при необходимости дозу можно увеличить до 200 мг/сут.
Для профилактики приступов мигрени назначают по 100-200 мг 1 раз/сут.
Пациентам пожилого возраста, пациентам с почечной недостаточностью или пациентам, находящимся на гемодиализе, коррекции дозы не требуется.
Нарушения функции печени влияют на выведение метопролола, поэтому может потребоваться коррекция дозы в зависимости от клинического состояния.
Полная инструкция
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Метопролол ретард-Акрихин таб. пролонг. действ. п/о плен.
Метопролол ретард-Акрихин таб. пролонг. действ. п/о плен., 50 мг, 30 шт.
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    Таблетница органайзер на неделю, контейнер для таблеток, бокс, на 7 дней, 4 приема, 28 ячеек

    Цена 361 ₽ вместо 690
  • Таблетница из 14 секций на семь дней Утро-вечер
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    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 167 ₽ вместо 200
  • Таблетница утро день вечер. На русском языке. 7 дней. Контейнер для таблеток на неделю. С названиями.
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    Таблетница утро день вечер. На русском языке. 7 дней. Контейнер для таблеток на неделю. С названиями.

    Цена 309 ₽ вместо 660
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 773 ₽ вместо 1 890
  • Контейнер для таблеток Таблетон макси 7 на 7 дней (4 приема в день)
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    Контейнер для таблеток Таблетон макси 7 на 7 дней (4 приема в день)

    Цена 569 ₽ вместо 575
  • Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

    Цена 223 ₽ вместо 599
  • Метопролол таб., 25 мг, 60 шт.
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    Метопролол таб., 25 мг, 60 шт.

    Цена 76 ₽
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 418 ₽ вместо 637
  • Реклама
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  • Метопролол таб., 25 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401076020_9/content/content/toggleWishlist":{"skuId":"862510031","productId":1401076020,"offerId":"_uR8XJRmRjBQpIe6hsvkNg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvqz44/+y16FNEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCLTyipwFEM+3o5sDGJe2+wUg19zBBw==","sign":"zKasQRxko0q/qMPWVXOkzMWdof3tBG8n1ZzRFdvIzGI="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401076020_9/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метопролол таб., 25 мг, 60 шт.

    Цена 70 ₽
  • Пилюля Таблетница на неделю Дорожная ( 7 дней по 4 отделения)
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1777978314_10/content/content/toggleWishlist":{"skuId":"623087054","productId":1777978314,"offerId":"4kXQxGFOBYPQgU1oTP9CeA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvqz44/+y16FNEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCMqX588GEM6bjqkCGMOLkAcgzc49","sign":"c0AfyZbzBhlR1YiHeQA9HF3UIGiOvt1XWZAhxLGn42U="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1777978314_10/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пилюля Таблетница на неделю Дорожная ( 7 дней по 4 отделения)

    Цена 587 ₽ вместо 799
  • Метопролол-акрихин таб., 50 мг, 60 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778173671_11/content/content/toggleWishlist":{"skuId":"228004260","productId":1778173671,"offerId":"Ke6AQlLZS4aMD7H4rl9rWg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvqz44/+y16FNEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCOeN888GEKSj3GwYntShBSDX3MEH","sign":"IGvOv0bGfc9ypXV08uNy8RRDa4Cd0+19uZfePgxpbwk="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778173671_11/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метопролол-акрихин таб., 50 мг, 60 шт.

    Цена 172 ₽
  • Контейнер для хранения/таблетница/кейс для таблеток
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    Контейнер для хранения/таблетница/кейс для таблеток

    Цена 365 ₽ вместо 699
  • Метопролол таб. пролонг. высвоб. п/о плен., 25 мг, 30 шт.
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    Метопролол таб. пролонг. высвоб. п/о плен., 25 мг, 30 шт.

    Цена 138 ₽
  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)
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    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)

    Цена 245 ₽ вместо 263
  • Пилюля Таблетница, с делителем ( 2 отделения )
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    Пилюля Таблетница, с делителем ( 2 отделения )

    Цена 201 ₽ вместо 291
  • Метопролол-Акрихин таб., 50 мг, 30 шт.
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    Метопролол-Акрихин таб., 50 мг, 30 шт.

    Цена 90 ₽
  • Эгилок таб., 25 мг, 60 шт.
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    Эгилок таб., 25 мг, 60 шт.

    Цена 79 ₽
  • Таблетница на день мини для капсул контейнер для таблеток белый
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    Таблетница на день мини для капсул контейнер для таблеток белый

    Цена 282 ₽ вместо 750
  • Метопролол Реневал таб., 50 мг, 30 шт.
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    Метопролол Реневал таб., 50 мг, 30 шт.

    Цена 82 ₽
  • Таблетница для лекарств и витаминов
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    Таблетница для лекарств и витаминов

    Цена 540 ₽ вместо 874
  • Реклама
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  • Метопролол Органика таб., 50 мг, 30 шт.
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    Метопролол Органика таб., 50 мг, 30 шт.

    Цена 54 ₽
  • Беталок Зок таб. с замедл. высвоб. п/о, 50 мг, 30 шт.
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    Беталок Зок таб. с замедл. высвоб. п/о, 50 мг, 30 шт.

    Цена 319 ₽ вместо 351
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