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Описание

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Мидокалм-Рихтер р-р для в/м введ. амп., 100 мг+2.5 мг/мл, 1 мл, 5 шт.

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4.8
(12)
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Коротко о товаре

Артикул Маркета
2186847726
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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Поэтому пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции почек. При тяжелом поражении почек назначение толперизона не рекомендуется.\u003Cbr /\u003EПациенты с печеночной недостаточностью\u003Cbr /\u003EОпыт применения толперизона у пациентов с печеночной недостаточностью ограничен, данной категории пациентов чаще возникали нежелательные реакции. Поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелом поражении печени назначение\tтолперизона не рекомендуется.\u003Cbr /\u003EПрименение у Детей\u003Cbr /\u003EПрепарат Мидокалм-Рихтер не предназначен для применения у детей и подростков в возрасте до 18 лет."},{"name":"Побочные действия","value":"Профиль безопасности толперизона оценивался по данным постмаркетингового применения более чем у 12000 пациентов.\u003Cbr /\u003EВ соответствии с этими данными, наиболее частыми были нарушения со стороны кожи и подкожных тканей, общие расстройства, нарушения со стороны нервной системы и желудочно-кишечного тракта.\u003Cbr /\u003EПри постмаркетинговом применении реакции повышенной чувствительности составили 50— 6094 всех побочных реакций. Большинство побочных реакций не были серьезными и проходили самостоятельно. Жизнеугрожающие реакции повышенной чувствительности регистрировались очень редко.\u003Cbr /\u003EПобочные реакции приведены ниже в соответствии с классификацией MedDRA и Частотой:\u003Cbr /\u003Eнечасто (от 21/1000 до \u003Cl/l()()); редко (от \u003E1/10000 до очень редко (\u003C1/10000); частота неизвестна (невозможно оценить на основании имеющихся данных).\u003Cbr /\u003EНарушения со стороны крови и лимфатической системы\u003Cbr /\u003EОчень редко: анемия, лимфаденопатия.\u003Cbr /\u003EНарушения со стороны иммунной системы\u003Cbr /\u003EРедко: реакция повышенной чувствительности, анафилактическая реакция.\u003Cbr /\u003EОчень редко: анафилактический шок.\u003Cbr /\u003EЧастота неизвестна: ангионевротический отек, включая отек лица, губ.\u003Cbr /\u003EНарушения со стороны обмена веществ и питания\u003Cbr /\u003EНечасто: анорексия.\u003Cbr /\u003EОчень редко: полидипсия.\u003Cbr /\u003EНарушения психики\u003Cbr /\u003EНечасто: бессонница, нарушения сна.\u003Cbr /\u003EРедко: снижение активности, депрессия.\u003Cbr /\u003EОчень редко: спутанность сознания.\u003Cbr /\u003EНарушения со стороны нервной системы\u003Cbr /\u003EНечасто: головная боль, головокружение, сонливость.\u003Cbr /\u003EРедко: нарушение внимания, тремор, эпилепсия, гипестезия, парестезия, летаргия.\u003Cbr /\u003EНарушения со стороны органа зрения\u003Cbr /\u003EРедко: нечеткость зрения.\u003Cbr /\u003EНарушения со стороны органа слуха и лабиринтные нарушения\u003Cbr /\u003EРедко: шум в ушах, вертиго.\u003Cbr /\u003EНарушения со стороны сердца\u003Cbr /\u003EРедко: стенокардия, тахикардия, ощущение сердцебиения.\u003Cbr /\u003EОчень редко: брадикардия.\u003Cbr /\u003EНарушения со стороны сосудов\u003Cbr /\u003EНечасто: артериальная гипотензия.\u003Cbr /\u003E \nРедко: «приливы».\u003Cbr /\u003EНарушения со стороны дыхательной системы. органов грудной клетки и средостения\u003Cbr /\u003EРедко: одышка, носовое кровотечение, учащенное дыхание.\u003Cbr /\u003EНарушения со стороны жедудочно-кишечного щракта\u003Cbr /\u003EНечасто: дискомфорт в животе, диарея, сухость во рту, диспепсия, тошнота.\u003Cbr /\u003EРедко: боль в эпигастральной области, запор, метеоризм, рвота.\u003Cbr /\u003EНарушения со стороны печени и желчевыводящих путей\u003Cbr /\u003EРедко: печеночная недостаточность легкой степени.\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr /\u003EРедко: аллергический дерматит, повышенная потливость, зуд, крапивница, сыпь.\u003Cbr /\u003EНарушения со стороны почек и мочевыводдгцих путей\u003Cbr /\u003EРедко: энурез, протеинурия.\u003Cbr /\u003EНарушения со стороны скелетно-мышечной и соединительной ткани\u003Cbr /\u003EНечасто: мышечная слабость, миалгия, боль в конечностях.\u003Cbr /\u003EРедко: дискомфорт в конечностях.\u003Cbr /\u003EОчень редко: остеопения.\u003Cbr /\u003EОбщие расстройства и нарушения в месте введения\u003Cbr /\u003EНечасто: астения, дискомфорт, усталость.\u003Cbr /\u003EРедко: чувство опьянения, чувство жара, раздражительность, жажда.\u003Cbr /\u003EОчень редко: дискомфорт в грудной клетке.\u003Cbr /\u003EЛабораторные и инструментальные данные\u003Cbr /\u003EРедко: снижение артериального давления, гипербилирубинемия, изменение активности печеночных ферментов, тромбоцитопения, лейкоцитоз.\u003Cbr /\u003EОчень редко: увеличение концентрации креатинина в плазме крови."},{"name":"Фармакологическое действие","value":"Фармакодинамика\u003Cbr /\u003EТолперизона гидрохлорид миорелаксант центрального действия. Оказывает мембраностабилизирующее, местноанестезирующее действие, тормозит проведение нервных импульсов в первичных афферентных волокнах и двигательных нейронах, что приводит к блокированию спинномозговых моно- и полисинаптических рефлексов. Предположительно, толперизон опосредует блокирование выделения медиаторов путем торможения поступления ионов кальция в синапсы. Тормозит проведение возбуждения по ретикулоспинальному пути в стволе головного мозга.\u003Cbr /\u003EНезависимо от влияния на центральную нервную систему усиливает периферическое кровообращение. Это действие не связано с воздействием препарата на центральную нервную систему и может быть обусловлено слабым спазмолитическим и антиадренергическим действием толперизона.\u003Cbr /\u003EЛидокаина гидрохлорид обладает местноанестезирующим действием и при дозировании согласно инструкции системного действия не оказывает."},{"name":"Фармакологическая группа","value":"миорелаксант центрального действия"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["35947170:36763748"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Условия хранения\u003Cbr /\u003EПри температуре от 8 до 15 ос в оригинальной упаковке (картонной пачке) для того, чтобы защитить от света.\u003Cbr /\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы передозировки чаще всего включают: сонливость, желудочно-кишечные нарушения (тошнота, рвота, боль в эпигастрии), тахикардия, повышение артериального давления, брадикинезия и вертиго. В тяжелых случаях судороги, угнетение дыхания, апноэ и кома. Лечение: специфического антидота нет, рекомендована симптоматическая терапия."},{"name":"Применение при беременности и кормлении грудью","value":"В экспериментальных исследованиях на животных не выявлено тератогенного действия толперизона. По причине отсутствия значимых клинических данных толперизон не следует применять при беременности, за исключением случаев, когда ожидаемая польза определенно оправдывает потенциальный риск для плода.\u003Cbr /\u003EПериод грудного вскармливания\u003Cbr /\u003EПоскольку данные о выделении толперизона с грудным молоком отсутствуют, то его применение в период кормления грудью противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Толперизон не оказывает влияния на способность управлять транспортными средствами и механизмами. Пациентам, у которых есть головокружение, сонливость, нарушение внимания, эпилепсия, нечеткость зрения или мышечная слабость во время применения толперизона, следует проконсультироваться с врачом."},{"name":"Особые указания","value":"Наиболее частыми нежелательными реакциями при применении толперизона в пострегистрационном периоде были реакции повышенной чувствительности. Их выраженность варьирует от легких кожных реакций до тяжелых системных реакций, включая анафилактический шок. Симптомами реакций повышенной чувствительности могут быть эритема, сыпь, крапивница, зуд, ангионевротический отек, тахикардия, артериальная гипотензия или одышка.\u003Cbr /\u003EЖенщины и пациенты с повышенной чувствительностью к другим препаратам или с аллергией в анамнезе могут быть подвержены более высокому риску повышенной чувствительности к толперизону.\u003Cbr /\u003EВ случае известной повышенной чувствительности к лидокаину при применении толперизона следует соблюдать повышенную осторожность из-за возможных перекрестных реакций.\u003Cbr /\u003EПациентам следует быть внимательными в отношении любых симптомов повышенной чувствительности. При возникновении симптомов следует немедленно прекратить прием препарата и незамедлительно обратиться к врачу. Не следует повторно назначать толперизон после эпизода повышенной чувствительности к лекарственному препарату, его содержащему.\u003Cbr /\u003EВспомогательные вещества\u003Cbr /\u003EПрепарат содержит метилпарагидроксибензоат, который может вызывать аллергические реакции (возможно, отсроченные) и, в исключительных случаях, бронхоспазм.\u003Cbr\u003EС осторожностью\u003Cbr /\u003EПрепарат следует применять с осторожностью у женщин, пациентов с повышенной чувствительностью к другим препаратам или с аллергией в анамнезе, у пациентов с почечной и печеночной недостаточностью."},{"name":"Взаимодействие","value":"Исследования фармакокинетического лекарственного взаимодействия с маркерным субстратом изофермента CYP2D6 декстраметорфаном показали, что одновременное применение толперизона может повысить содержание в крови лекарственных средств, которые метаболизируются преимущественно изоферментом CYP2D6 (тиоридазин, толтеродин, венлафаксин, атомоксетин, дезипрамин, декстрометорфан, метопролол, небиволол, перфеназин).\u003Cbr /\u003EВ лабораторных экспериментах на микросомах печени человека и гепатоцитах человека значительного ингибирования или индукции других изоферментов СУР (СУР2В6, СУР2С8, СУР2С9, СУР2С19, СУРIА2, СУРЗА4) не обнаружено.\u003Cbr /\u003EВ связи с разнообразием метаболических путей толперизона повышение экспозиции толперизона при одновременном применении субстратов изофермента CYP2D6 ИЛЛИ других препаратов не ожидается.\u003Cbr /\u003EНесмотря на то, что толперизон является препаратом центрального действия, седативный эффект его очень низкий. При одновременном применении с другими миорелаксантами центрального действия дозу толперизона следует уменьшить.\u003Cbr /\u003EТолперизон усиливает действие нифлумовой кислоты, поэтому при одновременном применении следует рассмотреть уменьшение дозы нифлумовой кислоты или других нестероидных противовоспалительных препаратов (НПВП)."},{"name":"Регистрационный номер","value":"ЛП-№(000473)-(РГ-RU); П N014846/01"},{"name":"Дата государственной регистрации","value":"22.12.2021; 04.06.2021"},{"name":"Владелец регистрационного удостоверения","value":"Гедеон Рихтер ОАО","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["34324371:35649313","7893318:17672958"]}}},{"name":"Изготовитель","value":"Гедеон Рихтер"},{"name":"Страна бренда","value":"Венгрия"},{"name":"Страна-производитель","value":"Венгрия"},{"name":"Название препарата","value":"Мидокалм-Рихтер","transition":{"type":"catalog","params":{"categorySlug":"sredstva-ot-travm-boli-v-myshtsakh-i-sustavakh","categoryId":"15756903","navnodeId":"25542230","glfilters":["17796364:18035368"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"1165401046845916701":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"опорно-двигательная система"},{"name":"Назначение","value":"спастичность скелетных мышц"},{"name":"Показания к применению","value":"Симптоматическое лечение спастичности у взрослых, обусловленной инсультом.\u003Cbr /\u003EМиофасциальный болевой синдром средней и тяжелой степени (в том числе мышечный спазм при дорсопатиях)."},{"name":"Противопоказания","value":"Повышенная чувствительность к толперизону или химически сходному эперизону или к любому из компонентов препарата (включая лидокаин).\u003Cbr /\u003EМиастения gravis.\u003Cbr /\u003EБеременность и период грудного вскармливания.\u003Cbr /\u003E Дети и подростки до 1 8 лет.\u003Cbr /\u003E"},{"name":"Состав","value":"Одна ампула содержит:\u003Cbr /\u003EДействующие вещества: толперизона гидрохлорид — 100 мг, лидокаина гидрохлорид 2,5 мг.\u003Cbr /\u003EВспомогательные вещества: метилпарагидроксибензоат, диэтиленгликоля моноэтиловый эфир, вода для инъекций."},{"name":"Действующее вещество","value":"Толперизон+Лидокаин"},{"name":"Способ применения и дозы","value":"Взрослым ежедневно по 1 мл (100 мг толперизона) 2 раза в сутки, внутримышечно.\u003Cbr /\u003EПациенты с почечнои недостаточностью Опыт применения толперизона у пациентов с почечной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции почек. При тяжелом поражении почек назначение толперизона не рекомендуется.\u003Cbr /\u003EПациенты с печеночной недостаточностью\u003Cbr /\u003EОпыт применения толперизона у пациентов с печеночной недостаточностью ограничен, данной категории пациентов чаще возникали нежелательные реакции. Поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелом поражении печени назначение\tтолперизона не рекомендуется.\u003Cbr /\u003EПрименение у Детей\u003Cbr /\u003EПрепарат Мидокалм-Рихтер не предназначен для применения у детей и подростков в возрасте до 18 лет."},{"name":"Побочные действия","value":"Профиль безопасности толперизона оценивался по данным постмаркетингового применения более чем у 12000 пациентов.\u003Cbr /\u003EВ соответствии с этими данными, наиболее частыми были нарушения со стороны кожи и подкожных тканей, общие расстройства, нарушения со стороны нервной системы и желудочно-кишечного тракта.\u003Cbr /\u003EПри постмаркетинговом применении реакции повышенной чувствительности составили 50— 6094 всех побочных реакций. Большинство побочных реакций не были серьезными и проходили самостоятельно. Жизнеугрожающие реакции повышенной чувствительности регистрировались очень редко.\u003Cbr /\u003EПобочные реакции приведены ниже в соответствии с классификацией MedDRA и Частотой:\u003Cbr /\u003Eнечасто (от 21/1000 до \u003Cl/l()()); редко (от \u003E1/10000 до очень редко (\u003C1/10000); частота неизвестна (невозможно оценить на основании имеющихся данных).\u003Cbr /\u003EНарушения со стороны крови и лимфатической системы\u003Cbr /\u003EОчень редко: анемия, лимфаденопатия.\u003Cbr /\u003EНарушения со стороны иммунной системы\u003Cbr /\u003EРедко: реакция повышенной чувствительности, анафилактическая реакция.\u003Cbr /\u003EОчень редко: анафилактический шок.\u003Cbr /\u003EЧастота неизвестна: ангионевротический отек, включая отек лица, губ.\u003Cbr /\u003EНарушения со стороны обмена веществ и питания\u003Cbr /\u003EНечасто: анорексия.\u003Cbr /\u003EОчень редко: полидипсия.\u003Cbr /\u003EНарушения психики\u003Cbr /\u003EНечасто: бессонница, нарушения сна.\u003Cbr /\u003EРедко: снижение активности, депрессия.\u003Cbr /\u003EОчень редко: спутанность сознания.\u003Cbr /\u003EНарушения со стороны нервной системы\u003Cbr /\u003EНечасто: головная боль, головокружение, сонливость.\u003Cbr /\u003EРедко: нарушение внимания, тремор, эпилепсия, гипестезия, парестезия, летаргия.\u003Cbr /\u003EНарушения со стороны органа зрения\u003Cbr /\u003EРедко: нечеткость зрения.\u003Cbr /\u003EНарушения со стороны органа слуха и лабиринтные нарушения\u003Cbr /\u003EРедко: шум в ушах, вертиго.\u003Cbr /\u003EНарушения со стороны сердца\u003Cbr /\u003EРедко: стенокардия, тахикардия, ощущение сердцебиения.\u003Cbr /\u003EОчень редко: брадикардия.\u003Cbr /\u003EНарушения со стороны сосудов\u003Cbr /\u003EНечасто: артериальная гипотензия.\u003Cbr /\u003E \nРедко: «приливы».\u003Cbr /\u003EНарушения со стороны дыхательной системы. органов грудной клетки и средостения\u003Cbr /\u003EРедко: одышка, носовое кровотечение, учащенное дыхание.\u003Cbr /\u003EНарушения со стороны жедудочно-кишечного щракта\u003Cbr /\u003EНечасто: дискомфорт в животе, диарея, сухость во рту, диспепсия, тошнота.\u003Cbr /\u003EРедко: боль в эпигастральной области, запор, метеоризм, рвота.\u003Cbr /\u003EНарушения со стороны печени и желчевыводящих путей\u003Cbr /\u003EРедко: печеночная недостаточность легкой степени.\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr /\u003EРедко: аллергический дерматит, повышенная потливость, зуд, крапивница, сыпь.\u003Cbr /\u003EНарушения со стороны почек и мочевыводдгцих путей\u003Cbr /\u003EРедко: энурез, протеинурия.\u003Cbr /\u003EНарушения со стороны скелетно-мышечной и соединительной ткани\u003Cbr /\u003EНечасто: мышечная слабость, миалгия, боль в конечностях.\u003Cbr /\u003EРедко: дискомфорт в конечностях.\u003Cbr /\u003EОчень редко: остеопения.\u003Cbr /\u003EОбщие расстройства и нарушения в месте введения\u003Cbr /\u003EНечасто: астения, дискомфорт, усталость.\u003Cbr /\u003EРедко: чувство опьянения, чувство жара, раздражительность, жажда.\u003Cbr /\u003EОчень редко: дискомфорт в грудной клетке.\u003Cbr /\u003EЛабораторные и инструментальные данные\u003Cbr /\u003EРедко: снижение артериального давления, гипербилирубинемия, изменение активности печеночных ферментов, тромбоцитопения, лейкоцитоз.\u003Cbr /\u003EОчень редко: увеличение концентрации креатинина в плазме крови."},{"name":"Фармакологическое действие","value":"Фармакодинамика\u003Cbr /\u003EТолперизона гидрохлорид миорелаксант центрального действия. Оказывает мембраностабилизирующее, местноанестезирующее действие, тормозит проведение нервных импульсов в первичных афферентных волокнах и двигательных нейронах, что приводит к блокированию спинномозговых моно- и полисинаптических рефлексов. Предположительно, толперизон опосредует блокирование выделения медиаторов путем торможения поступления ионов кальция в синапсы. Тормозит проведение возбуждения по ретикулоспинальному пути в стволе головного мозга.\u003Cbr /\u003EНезависимо от влияния на центральную нервную систему усиливает периферическое кровообращение. Это действие не связано с воздействием препарата на центральную нервную систему и может быть обусловлено слабым спазмолитическим и антиадренергическим действием толперизона.\u003Cbr /\u003EЛидокаина гидрохлорид обладает местноанестезирующим действием и при дозировании согласно инструкции системного действия не оказывает."},{"name":"Фармакологическая группа","value":"миорелаксант центрального действия"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Условия хранения\u003Cbr /\u003EПри температуре от 8 до 15 ос в оригинальной упаковке (картонной пачке) для того, чтобы защитить от света.\u003Cbr /\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы передозировки чаще всего включают: сонливость, желудочно-кишечные нарушения (тошнота, рвота, боль в эпигастрии), тахикардия, повышение артериального давления, брадикинезия и вертиго. В тяжелых случаях судороги, угнетение дыхания, апноэ и кома. Лечение: специфического антидота нет, рекомендована симптоматическая терапия."},{"name":"Применение при беременности и кормлении грудью","value":"В экспериментальных исследованиях на животных не выявлено тератогенного действия толперизона. По причине отсутствия значимых клинических данных толперизон не следует применять при беременности, за исключением случаев, когда ожидаемая польза определенно оправдывает потенциальный риск для плода.\u003Cbr /\u003EПериод грудного вскармливания\u003Cbr /\u003EПоскольку данные о выделении толперизона с грудным молоком отсутствуют, то его применение в период кормления грудью противопоказано."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Толперизон не оказывает влияния на способность управлять транспортными средствами и механизмами. Пациентам, у которых есть головокружение, сонливость, нарушение внимания, эпилепсия, нечеткость зрения или мышечная слабость во время применения толперизона, следует проконсультироваться с врачом."},{"name":"Особые указания","value":"Наиболее частыми нежелательными реакциями при применении толперизона в пострегистрационном периоде были реакции повышенной чувствительности. Их выраженность варьирует от легких кожных реакций до тяжелых системных реакций, включая анафилактический шок. Симптомами реакций повышенной чувствительности могут быть эритема, сыпь, крапивница, зуд, ангионевротический отек, тахикардия, артериальная гипотензия или одышка.\u003Cbr /\u003EЖенщины и пациенты с повышенной чувствительностью к другим препаратам или с аллергией в анамнезе могут быть подвержены более высокому риску повышенной чувствительности к толперизону.\u003Cbr /\u003EВ случае известной повышенной чувствительности к лидокаину при применении толперизона следует соблюдать повышенную осторожность из-за возможных перекрестных реакций.\u003Cbr /\u003EПациентам следует быть внимательными в отношении любых симптомов повышенной чувствительности. При возникновении симптомов следует немедленно прекратить прием препарата и незамедлительно обратиться к врачу. Не следует повторно назначать толперизон после эпизода повышенной чувствительности к лекарственному препарату, его содержащему.\u003Cbr /\u003EВспомогательные вещества\u003Cbr /\u003EПрепарат содержит метилпарагидроксибензоат, который может вызывать аллергические реакции (возможно, отсроченные) и, в исключительных случаях, бронхоспазм.\u003Cbr\u003EС осторожностью\u003Cbr /\u003EПрепарат следует применять с осторожностью у женщин, пациентов с повышенной чувствительностью к другим препаратам или с аллергией в анамнезе, у пациентов с почечной и печеночной недостаточностью."},{"name":"Взаимодействие","value":"Исследования фармакокинетического лекарственного взаимодействия с маркерным субстратом изофермента CYP2D6 декстраметорфаном показали, что одновременное применение толперизона может повысить содержание в крови лекарственных средств, которые метаболизируются преимущественно изоферментом CYP2D6 (тиоридазин, толтеродин, венлафаксин, атомоксетин, дезипрамин, декстрометорфан, метопролол, небиволол, перфеназин).\u003Cbr /\u003EВ лабораторных экспериментах на микросомах печени человека и гепатоцитах человека значительного ингибирования или индукции других изоферментов СУР (СУР2В6, СУР2С8, СУР2С9, СУР2С19, СУРIА2, СУРЗА4) не обнаружено.\u003Cbr /\u003EВ связи с разнообразием метаболических путей толперизона повышение экспозиции толперизона при одновременном применении субстратов изофермента CYP2D6 ИЛЛИ других препаратов не ожидается.\u003Cbr /\u003EНесмотря на то, что толперизон является препаратом центрального действия, седативный эффект его очень низкий. При одновременном применении с другими миорелаксантами центрального действия дозу толперизона следует уменьшить.\u003Cbr /\u003EТолперизон усиливает действие нифлумовой кислоты, поэтому при одновременном применении следует рассмотреть уменьшение дозы нифлумовой кислоты или других нестероидных противовоспалительных препаратов (НПВП)."},{"name":"Регистрационный номер","value":"ЛП-№(000473)-(РГ-RU); П N014846/01"},{"name":"Дата государственной регистрации","value":"22.12.2021; 04.06.2021"},{"name":"Владелец регистрационного удостоверения","value":"Гедеон Рихтер ОАО"},{"name":"Изготовитель","value":"Гедеон Рихтер"},{"name":"Страна бренда","value":"Венгрия"},{"name":"Страна-производитель","value":"Венгрия"},{"name":"Название препарата","value":"Мидокалм-Рихтер"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_17880752415233582653"}}}}
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Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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Ещё может подойти

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Инструкция

Показания к применению

Симптоматическое лечение спастичности у взрослых, обусловленной инсультом.
Миофасциальный болевой синдром средней и тяжелой степени (в том числе мышечный спазм при дорсопатиях).

Противопоказания

Повышенная чувствительность к толперизону или химически сходному эперизону или к любому из компонентов препарата (включая лидокаин).
Миастения gravis.
Беременность и период грудного вскармливания.
Дети и подростки до 1 8 лет.

Способ применения и дозы

Взрослым ежедневно по 1 мл (100 мг толперизона) 2 раза в сутки, внутримышечно.
Пациенты с почечнои недостаточностью Опыт применения толперизона у пациентов с почечной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции почек. При тяжелом поражении почек назначение толперизона не рекомендуется.
Пациенты с печеночной недостаточностью
Опыт применения толперизона у пациентов с печеночной недостаточностью ограничен, данной категории пациентов чаще возникали нежелательные реакции. Поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелом поражении печени назначение толперизона не рекомендуется.
Применение у Детей
Препарат Мидокалм-Рихтер не предназначен для применения у детей и подростков в возрасте до 18 лет.
Полная инструкция
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Мидокалм-Рихтер р-р для в/м введ. амп.
Мидокалм-Рихтер р-р для в/м введ. амп., 100 мг+2.5 мг/мл, 1 мл, 5 шт.
4.8
(12)
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5 вопросов
Инструкция
Нет в продаже
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4.8
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У продавца:12 оценок·5 отзывов
У всех продавцов:91 оценка·28 отзывов
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user avatar
Месяц назад • Иван М. • Куплен на Маркете
Достоинства: помогает и облегчает состояние
Недостатки: нет
Комментарий: лучшее
user avatar
4 дня назад • Ольга Макаренкова • Куплен на Маркете
Достоинства: помогает
Недостатки: нет
user avatar
6 месяцев назад • Сергей Полосков • Куплен на Маркете
Недостатки: нет
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Рекомендуем

  • Мидокалм таб. п/о плен., 50 мг, 30 шт.
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    Мидокалм таб. п/о плен., 50 мг, 30 шт.

    Цена 523 ₽ вместо 633
  • Мидокалм Лонг таб. пролонг. высвоб. п/о плен., 450 мг, 10 шт.
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    Мидокалм Лонг таб. пролонг. высвоб. п/о плен., 450 мг, 10 шт.

    Цена 544 ₽
  • Мовалис р-р для в/м введ., 15 мг/1.5 мл, 1.5 мл, 3 шт.
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    Комбилипен р-р д/ин., 5 шт.

    Цена 337 ₽
  • Мильгамма р-р для в/м введ., 5 шт.
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    Мильгамма р-р для в/м введ., 5 шт.

    Цена 596 ₽ вместо 739
  • Нейромультивит р-р для в/м введ. амп., 5 шт.
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    Нейромультивит р-р для в/м введ. амп., 5 шт.

    Цена 512 ₽
  • Артрозан р-р для в/м введ., 6 мг/мл, 2.5 мл, 3 шт.
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    Артрозан р-р для в/м введ., 6 мг/мл, 2.5 мл, 3 шт.

    Цена 415 ₽
  • Vitamin D3, 10000 МЕ, 120 шт.
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    Vitamin D3, 10000 МЕ, 120 шт.

    Цена 1 209 ₽ вместо 2 455
  • Реклама
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  • ЛимфоТранзит концентрат напитка фл., 100 мл
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.
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    Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.

    Цена 421 ₽ вместо 425
  • Мелоксикам р-р для в/м введ., 10 мг/мл, 1.5 мл, 3 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228004251_11/content/content/gallery":{"title":"Мелоксикам р-р для в/м введ., 10 мг/мл, 1.5 мл, 3 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/331398/img_id1854155186917984635.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/331398/img_id1854155186917984635.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/331398/img_id1854155186917984635.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/331398/img_id1854155186917984635.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/331398/img_id1854155186917984635.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/331398/img_id1854155186917984635.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5226473/img_id2234415219123589058.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5226473/img_id2234415219123589058.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5226473/img_id2234415219123589058.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5226473/img_id2234415219123589058.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5226473/img_id2234415219123589058.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5226473/img_id2234415219123589058.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQmbrRq43AgYVXEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCJuj3GwQ+dyZnfsCGMWp6AYg59zBBw==","sign":"/fbWhZiBAnU2K9KdComxAlPFZyvPOEMHdGtVbaPmUjs="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:228004251_11/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Мелоксикам р-р для в/м введ., 10 мг/мл, 1.5 мл, 3 шт.

    Цена 118 ₽
  • Жидкий пластырь Fixplast c пантенолом, 60 мл
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    Жидкий пластырь Fixplast c пантенолом, 60 мл

    Цена 355 ₽ вместо 399
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 2 025 ₽ вместо 3 500
  • Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов
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    Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов

    Цена 194 ₽ вместо 224
  • Амелотекс р-р для в/м введ., 10 мг/мл, 1.5 мл, 3 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1422663435_15/content/content/toggleWishlist":{"skuId":"186854014","productId":1422663435,"offerId":"nJk6BGm14ZbOt-PfhsYV8A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQmbrRq43AgYVXEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCIu+sKYFEP7UjFkYoOqQByDn3MEH","sign":"5i5/UflvxSRlQ9yBFyS9CHEpRD1/ybBAOgDB5FOUNU4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1422663435_15/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Амелотекс р-р для в/м введ., 10 мг/мл, 1.5 мл, 3 шт.

    Цена 490 ₽
  • Хило-комод р-р увлажняющий офтальмологический конт., 1 мг/мл, 10 мл, 1 шт.
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    Хило-комод р-р увлажняющий офтальмологический конт., 1 мг/мл, 10 мл, 1 шт.

    Цена 754 ₽ вместо 762
  • Салфетка с нашатырем для стимуляции дыхания 3х6, 20 шт
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    Салфетка с нашатырем для стимуляции дыхания 3х6, 20 шт

    Цена 199 ₽ вместо 250
  • Калмирекс р-р для в/в введ. и в/м введ. амп., 100 мг/мл+2.5 мг/мл, 1 мл, 5 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:265134753_18/content/content/gallery":{"title":"Калмирекс р-р для в/в введ. и в/м введ. амп., 100 мг/мл+2.5 мг/мл, 1 мл, 5 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5221441/img_id8696455395400999269.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5221441/img_id8696455395400999269.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5221441/img_id8696455395400999269.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5221441/img_id8696455395400999269.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5221441/img_id8696455395400999269.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5221441/img_id8696455395400999269.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1539743/img_id7733964316075389433.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1539743/img_id7733964316075389433.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1539743/img_id7733964316075389433.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1539743/img_id7733964316075389433.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1539743/img_id7733964316075389433.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1539743/img_id7733964316075389433.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQmbrRq43AgYVXEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCKHFtn4Qucjd2/kCGKDqkAcg59zBBw==","sign":"lD5ojIp1m0XoXXsFZ5nszT6A0xl2LGQGiJa0Xj+4lDg="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:265134753_18/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Калмирекс р-р для в/в введ. и в/м введ. амп., 100 мг/мл+2.5 мг/мл, 1 мл, 5 шт.

    Цена 552 ₽
  • Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1767665215_19/content/content/gallery":{"title":"Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5220188/img_id8950206855638525611.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5220188/img_id8950206855638525611.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5220188/img_id8950206855638525611.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5220188/img_id8950206855638525611.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5220188/img_id8950206855638525611.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5220188/img_id8950206855638525611.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4370207/img_id2444190599973659561.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4370207/img_id2444190599973659561.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4370207/img_id2444190599973659561.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4370207/img_id2444190599973659561.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4370207/img_id2444190599973659561.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4370207/img_id2444190599973659561.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4345877/img_id5133760612892526506.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4345877/img_id5133760612892526506.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4345877/img_id5133760612892526506.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4345877/img_id5133760612892526506.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4345877/img_id5133760612892526506.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4345877/img_id5133760612892526506.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5232557/img_id3396566504635398323.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5232557/img_id3396566504635398323.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5232557/img_id3396566504635398323.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5232557/img_id3396566504635398323.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5232557/img_id3396566504635398323.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5232557/img_id3396566504635398323.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/7388241/img_id3853740688187439600.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/7388241/img_id3853740688187439600.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/7388241/img_id3853740688187439600.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/7388241/img_id3853740688187439600.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/7388241/img_id3853740688187439600.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/7388241/img_id3853740688187439600.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQmbrRq43AgYVXEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCL/c8coGENym2KH7AhjV1M8GIMXYwQc=","sign":"cZj9LfHG49/W6E7d2NbRjAmmWsP+erUYOjWw0B9Ny40="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1767665215_19/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.

    Цена 285 ₽ вместо 520
  • Алфлутоп р-р д/ин. амп., 1 мл, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1422663437_20/content/content/gallery":{"title":"Алфлутоп р-р д/ин. амп., 1 мл, 10 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4393885/img_id7509663343783934238.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4393885/img_id7509663343783934238.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4393885/img_id7509663343783934238.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4393885/img_id7509663343783934238.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4393885/img_id7509663343783934238.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4393885/img_id7509663343783934238.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4408567/img_id4470688463255491926.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4408567/img_id4470688463255491926.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id4470688463255491926.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id4470688463255491926.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id4470688463255491926.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id4470688463255491926.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQmbrRq43AgYVXEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCI2+sKYFEKKh3GwY8MLVByDn3MEH","sign":"djaGFZdAkUN62LMjqQjpkkPhjFgI+g9Mju6iC/QS4gY="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1422663437_20/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Алфлутоп р-р д/ин. амп., 1 мл, 10 шт.

    Цена 2 366 ₽ вместо 2 697
  • Реклама
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  • Хондрогард р-р для в/м и в/суст. введ., 100 мг/мл, 1 мл, 10 шт.
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    Хондрогард р-р для в/м и в/суст. введ., 100 мг/мл, 1 мл, 10 шт.

    Цена 1 795 ₽
  • Кетоконазол шампунь лекарственный, 2%, 150 г
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    Кетоконазол шампунь лекарственный, 2%, 150 г

    Цена 457 ₽ вместо 462
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