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Описание

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Мирвазо Дерм гель д/нар. прим., 0,5%, 30 мл, 30 г

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4.6
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Коротко о товаре

Артикул Маркета
3123233493
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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5,0 мг.\u003Cbr /\u003EВспомогательные вещества: карбомер - 12,5 мг, метилпарагидроксибензоат - 1,0 мг, феноксиэтанол - 4,0 мг, глицерол - 55,0 мг, титана диоксид - 0,625 мг, пропиленгликоль - 55,0 мг, натрия гидроксид - до pH 6,0, вода очищенная - до 1000 мг.\u003Cbr /\u003E"},{"name":"Действующее вещество","value":"Бримонидин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["27144131:28709629"]}}},{"name":"Способ применения и дозы","value":"Только для наружного применения.\u003Cbr /\u003EНебольшое количество геля тонким слоем наносят на кожу каждой из 5 зон лица (лоб, подбородок, нос, щеки) 1 раз в сутки при наличии эритемы.\u003Cbr /\u003EПри нанесении на кожу гель Мирвазо Дерм необходимо распределять равномерно тонким слоем по лицу, избегая попадания препарата в глаза, на веки, губы, рот и слизистую оболочку носа.\u003Cbr /\u003EГель следует наносить только на лицо.\u003Cbr /\u003EМаксимальная рекомендуемая суточная доза препарата составляет 1 г (что примерно соответствует размеру 5 спичечных головок).\u003Cbr /\u003EЛечение следует начинать с небольшого количества геля (меньше максимальной суточной дозы) продолжительностью в течение не менее одной недели. Далее количество наносимого препарата может постепенно увеличиваться, в зависимости от его переносимости и эффективности лечения.\u003Cbr /\u003EПосле применения препарата необходимо обязательно вымыть руки.\u003Cbr /\u003E"},{"name":"Побочные действия","value":"Наиболее частые нежелательные реакции, включающие покраснение, зуд, приливы и ощущение жжения кожи, были отмечены у пациентов в 1,2-3,3% случаев при проведении клинических исследований. Как правило, это были реакции легкой или средней степени тяжести, которые не приводили к прекращению лечения.\u003Cbr /\u003EСообщалось о случаях обострения симптомов розацеа у пациентов, получавших лечение препаратом Мирвазо Дерм. Учитывая данные всех проведенных клинических исследований, случаи обострения симптомов были отмечены у 16% пациентов.\u003Cbr /\u003EЗначимого различия в профиле безопасности у пожилых пациентов и пациентов в возрасте от 18 до 65 лет выявлено не было.\u003Cbr /\u003EВ пострегистрационный период были отмечены частые случаи усиления покраснения, приливов, ощущения жжения кожи и побледнение кожи в месте нанесения. В пострегистрационный период были также зарегистрированы нечастые случаи головокружения, а также случаи брадикардии и гипотензии (включая ортостатическую гипотензию) с частотой встречаемости \"Редко\", некоторые из которых привели к госпитализации. В некоторых случаях данные нежелательные реакции возникли вследствие нанесения геля Мирвазо Дерм после проведения лазерной терапии.\u003Cbr /\u003EНежелательные реакции, полученные при проведении клинических исследований и в пострегистрационный период (см. Таблицу 1), классифицированы по системам органов и частоте развития. Частоту побочных реакций классифицировали следующим образом: очень часто (≥1/10), часто (≥1/100 до \u003C1/10), нечасто (≥1/1000 до \u003C1/100), редко (≥1/10000 до \u003C1/1000), очень редко (\u003C1/10000), частота неизвестна (невозможно оценить, исходя из имеющихся данных).\u003Cbr /\u003EТаблица 1\u003Cbr /\u003EКласс систем органов\u003Cbr /\u003E - \u003Cbr /\u003EЧастота встречаемости\u003Cbr /\u003E - \u003Cbr /\u003EНежелательные реакции\u003Cbr /\u003EНарушения со стороны нервной системы\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EГоловная боль, парестезии, головокружение*\u003Cbr /\u003EНарушения со стороны органа зрения\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EОтек век\u003Cbr /\u003EНарушения со стороны сосудов\u003Cbr /\u003E - \u003Cbr /\u003EЧасто\u003Cbr /\u003E - \u003Cbr /\u003EПриливы\u003Cbr /\u003EРедко\u003Cbr /\u003E - \u003Cbr /\u003EГипотензия*, брадикардия*\u003Cbr /\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EЗаложенность носа\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EСухость во рту\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr /\u003E - \u003Cbr /\u003EЧасто\u003Cbr /\u003E - \u003Cbr /\u003EПокраснение, зуд, ощущение жжения кожи, розацеа, побледнение кожи в месте нанесения*\u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EДерматит, раздражение кожи, ощущение тепла, контактный дерматит, аллергический контактный дерматит, сухость кожи, болезненность кожи, кожный дискомфорт, папулезная сыпь, акне, отечность лица*, крапивница*\u003Cbr /\u003EРедко\u003Cbr /\u003E - \u003Cbr /\u003EОтек Квинке*\u003Cbr /\u003EОбщие расстройства и нарушения в месте нанесения\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EЧувство жара, чувство холода в месте нанесения\u003Cbr /\u003E*Данные о побочных действиях, полученные в пострегистрационный период.\u003Cbr /\u003EЕсли любые из указанных в инструкции побочных эффектов усугубляются, или отмечаются любые другие побочные эффекты, не указанные в инструкции, следует немедленно сообщить об этом врачу.\u003Cbr /\u003E"},{"name":"Фармакологическое действие","value":"Бримонидин является высокоселективным агонистом альфа2-адренергических рецепторов: его сродство к альфа2-адренергическим рецепторам в 1000 раз превышает сродство к альфа1-адренергическим рецепторам.\u003Cbr /\u003EНанесение на кожу лица высокоселективного агониста альфа2-адренергических рецепторов приводит к уменьшению эритемы за счет прямой вазоконстрикции мелких кровеносных сосудов дермы.\u003Cbr /\u003E"},{"name":"Фармакологическая группа","value":"альфа-адреномиметики"},{"name":"Форма выпуска","value":"гель"},{"name":"Способ применения/введения","value":"наружный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["35947170:36763741"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 30 °С. Не замораживать. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Информация о передозировке бримонидином при наружном применении у взрослых пациентов отсутствует.\u003Cbr /\u003EПри случайном применении препарата внутрь возможны такие явления передозировки агонистами альфа2-рецепторов, как гипотензия, слабость, рвота, сонливость, заторможенность, брадикардия, аритмия, миоз, апноэ, гипотония, гипотермия, угнетение дыхания и судороги.\u003Cbr /\u003EВ ходе клинического исследования было отмечено 2 случая серьезных нежелательных явлений, вызванных случайным проглатыванием Мирвазо Дерм детьми младшего возраста. Наблюдаемые у детей симптомы соответствовали известным симптомам передозировки агонистов альфаг-рецепторов у детей младшего возраста и в течение 24 часов полностью исчезли.\u003Cbr /\u003EЛечение передозировки при приеме препарата внутрь включает поддерживающую и симптоматическую терапию, необходимо поддерживать проходимость дыхательных путей.\u003Cbr /\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Данные о применении бримонидина при беременности ограничены или отсутствуют.\u003Cbr\u003E Исследования репродуктивной токсичности на животных не выявили прямых или косвенных неблагоприятных эффектов препарата. В качестве меры предосторожности рекомендуется избегать применения препарата Мирвазо Дерм при беременности.\u003Cbr\u003E Неизвестно, выделяются ли бримонидин и его метаболиты с грудным молоком. В связи с этим невозможно исключить риск для новорожденных и грудных детей. Решение о прекращении грудного вскармливания или применения препарата Мирвазо Дерм должно быть принято, принимая во внимание важность применения препарата для матери."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат не влияет или незначительно влияет на способность управлять транспортными средствами или заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr /\u003E- Беременность;\u003Cbr /\u003E- Нарушение функции печени и почек (исследования применения препарата Мирвазо® Дерм у данной категории пациентов не проводились).\u003Cbr /\u003EПрепарат Мирвазо Дерм не следует наносить на раздраженную кожу (в том числе после проведения лазерной терапии) или открытые раны, на область вокруг глаз. В случае выраженного раздражения или аллергии необходимо прервать лечение препаратом.\u003Cbr /\u003EПрепарат Мирвазо Дерм возможно использовать совместно с другими для лечения воспалительных элементов при розацеа, и косметическими средствами. Они могут быть нанесены на кожу только после высыхания препарата Мирвазо Дерм, а не непосредственно перед ним.\u003Cbr /\u003EЭритема и приливы\u003Cbr /\u003EДействие препарата Мирвазо Дерм начинает ослабевать через несколько часов после нанесения. У некоторых пациентов было описано возобновление эритемы и приливов в более тяжелой форме, чем наблюдалось до лечения. Большинство таких случаев отмечалось в течение первых 2 недель после начала лечения.\u003Cbr /\u003EУ некоторых пациентов, получавших терапию Мирвазо Дерм, наблюдались приливы. Время начала их развития варьировало от 30 минут до нескольких часов после нанесения геля.\u003Cbr /\u003EВ большинстве случаев эритема и приливы проходили после отмены препарата.\u003Cbr /\u003EВ случае усугубления эритемы применение Мирвазо Дерм следует приостановить. Симптоматические меры, например, охлаждающие примочки, прием нестероидных противовоспалительных и антигистаминных препаратов, могут облегчить симптомы.\u003Cbr /\u003EПосле возобновления применения препарата Мирвазо Дерм отмечались случаи обострения эритемы и приливов в усугубленной форме. После временного перерыва в лечении возобновление применения Мирвазо Дерм необходимо начинать с пробного нанесения препарата на небольшой участок кожи лица не менее чем за 1 день до перехода к лечению препаратом при его нанесении на всю поверхность кожи лица.\u003Cbr /\u003EСледует строго соблюдать рекомендованную дозу и частоту нанесения: один раз в день, очень тонким слоем.\u003Cbr /\u003EНеобходимо избегать увеличения максимальной суточной дозы и/ или частоты применения, так как безопасность повышенных суточных доз или многократного ежедневного применения не установлена.\u003Cbr /\u003EОдновременное применение с системными агонистами альфа-адренергических рецепторов может усиливать побочные эффекты данного класса лекарственных препаратов у пациентов с:\u003Cbr /\u003E- тяжелыми или неконтролируемыми, или нестабильными сердечно-сосудистыми заболеваниями;\u003Cbr /\u003E- депрессией, недостаточностью мозгового или коронарного кровообращения, болезнью Рейно, ортостатической гипотензией, облитерирующими тромбоангиитами, склеродермией или синдромом Шегрена.\u003Cbr /\u003EВ состав препарата Мирвазо Дерм входит метилпарагидроксибензоат, который может вызвать аллергические реакции (возможно, замедленного типа), а также пропиленгликоль, который может привести к раздражению кожи.\u003Cbr /\u003E"},{"name":"Взаимодействие","value":"Исследований по изучению взаимодействий препарата с другими лекарственными средствами не проводилось.\u003Cbr /\u003EИнгибиторы моноаминоксидазы (МАО) могут теоритически препятствовать усвоению бримонидина и потенциально приводить к увеличению системных побочных действий, таких как гипотензия, а также оказывать влияние на метаболический процесс и усвоение циркулирующих аминов.\u003Cbr /\u003EНеобходимо учитывать возможность добавочного или потенцирующего действия при совместном применении бримонидина с препаратами, угнетающими центральную нервную систему (алкоголь, барбитураты, опиаты, седативные препараты или анестетики).\u003Cbr /\u003EДанные о влиянии бримонидина на уровень циркулирующих катехоламинов отсутствуют. Тем не менее рекомендуется соблюдать осторожность при назначении бримонидина пациентам, получающим препараты, которые способны влиять на метаболизм аминов и повышать их концентрацию в крови, такие как хлорпромазин, метилфенидат, резерпин.\u003Cbr /\u003EРекомендуется соблюдать осторожность в начале лечения или изменении дозы совместно назначаемых системных препаратов (независимо от их лекарственной формы), которые могут взаимодействовать с агонистами альфа-адренергических рецепторов или влиять на их действия, т.е. являются агонистами или антагонистами адренергических рецепторов (например, изопреналин, празозин).\u003Cbr /\u003EУ некоторых пациентов бримонидин способен вызывать клинически незначимое снижение артериального давления, поэтому следует соблюдать осторожность при применении таких препаратов, как гипотензивные средства и/или сердечные гликозиды, одновременно с препаратом Мирвазо Дерм.\u003Cbr /\u003E"},{"name":"Регистрационный номер","value":"ЛП-003563"},{"name":"Дата государственной регистрации","value":"12.04.2016"},{"name":"Владелец регистрационного удостоверения","value":"Galderma","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["34324371:35649313","7893318:11906575"]}}},{"name":"Изготовитель","value":"Galderma"},{"name":"Фасовщик","value":"Galderma"},{"name":"Страна бренда","value":"Швейцария"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Мирвазо дерм","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["17796364:17879611"]}}},{"name":"Срок годности","value":"24 мес."}]}},"fullSpecsGrouped":{"9432209103114963014":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кожа"},{"name":"Назначение","value":"розацеа"},{"name":"Показания к применению","value":"Лечение эритемы лица при розацеа."},{"name":"Противопоказания","value":"- Повышенная чувствительность к бримонидину или к любому из вспомогательных веществ;\u003Cbr /\u003E- Детский возраст до 2 лет (из-за серьезного системного риска);\u003Cbr /\u003E- Детский возраст от 2 до 18 лет (безопасность и эффективность препарата для данной возрастной категории не установлена);\u003Cbr /\u003E- Одновременный прием с ингибиторами моноаминоксидазы (МАО) (например, селегилин или моклобемид), и трициклическими (имипрамин) и тетрациклическими (мапротилин, миансерин и миртазапин) антидепрессантами, оказывающими влияние на норадренергическую передачу.\u003Cbr /\u003E"},{"name":"Состав","value":"1 г геля содержит:\u003Cbr /\u003EДействующее вещество:\u003Cbr /\u003EБримонидина тартрат - 5,0 мг.\u003Cbr /\u003EВспомогательные вещества: карбомер - 12,5 мг, метилпарагидроксибензоат - 1,0 мг, феноксиэтанол - 4,0 мг, глицерол - 55,0 мг, титана диоксид - 0,625 мг, пропиленгликоль - 55,0 мг, натрия гидроксид - до pH 6,0, вода очищенная - до 1000 мг.\u003Cbr /\u003E"},{"name":"Действующее вещество","value":"Бримонидин"},{"name":"Способ применения и дозы","value":"Только для наружного применения.\u003Cbr /\u003EНебольшое количество геля тонким слоем наносят на кожу каждой из 5 зон лица (лоб, подбородок, нос, щеки) 1 раз в сутки при наличии эритемы.\u003Cbr /\u003EПри нанесении на кожу гель Мирвазо Дерм необходимо распределять равномерно тонким слоем по лицу, избегая попадания препарата в глаза, на веки, губы, рот и слизистую оболочку носа.\u003Cbr /\u003EГель следует наносить только на лицо.\u003Cbr /\u003EМаксимальная рекомендуемая суточная доза препарата составляет 1 г (что примерно соответствует размеру 5 спичечных головок).\u003Cbr /\u003EЛечение следует начинать с небольшого количества геля (меньше максимальной суточной дозы) продолжительностью в течение не менее одной недели. Далее количество наносимого препарата может постепенно увеличиваться, в зависимости от его переносимости и эффективности лечения.\u003Cbr /\u003EПосле применения препарата необходимо обязательно вымыть руки.\u003Cbr /\u003E"},{"name":"Побочные действия","value":"Наиболее частые нежелательные реакции, включающие покраснение, зуд, приливы и ощущение жжения кожи, были отмечены у пациентов в 1,2-3,3% случаев при проведении клинических исследований. Как правило, это были реакции легкой или средней степени тяжести, которые не приводили к прекращению лечения.\u003Cbr /\u003EСообщалось о случаях обострения симптомов розацеа у пациентов, получавших лечение препаратом Мирвазо Дерм. Учитывая данные всех проведенных клинических исследований, случаи обострения симптомов были отмечены у 16% пациентов.\u003Cbr /\u003EЗначимого различия в профиле безопасности у пожилых пациентов и пациентов в возрасте от 18 до 65 лет выявлено не было.\u003Cbr /\u003EВ пострегистрационный период были отмечены частые случаи усиления покраснения, приливов, ощущения жжения кожи и побледнение кожи в месте нанесения. В пострегистрационный период были также зарегистрированы нечастые случаи головокружения, а также случаи брадикардии и гипотензии (включая ортостатическую гипотензию) с частотой встречаемости \"Редко\", некоторые из которых привели к госпитализации. В некоторых случаях данные нежелательные реакции возникли вследствие нанесения геля Мирвазо Дерм после проведения лазерной терапии.\u003Cbr /\u003EНежелательные реакции, полученные при проведении клинических исследований и в пострегистрационный период (см. Таблицу 1), классифицированы по системам органов и частоте развития. Частоту побочных реакций классифицировали следующим образом: очень часто (≥1/10), часто (≥1/100 до \u003C1/10), нечасто (≥1/1000 до \u003C1/100), редко (≥1/10000 до \u003C1/1000), очень редко (\u003C1/10000), частота неизвестна (невозможно оценить, исходя из имеющихся данных).\u003Cbr /\u003EТаблица 1\u003Cbr /\u003EКласс систем органов\u003Cbr /\u003E - \u003Cbr /\u003EЧастота встречаемости\u003Cbr /\u003E - \u003Cbr /\u003EНежелательные реакции\u003Cbr /\u003EНарушения со стороны нервной системы\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EГоловная боль, парестезии, головокружение*\u003Cbr /\u003EНарушения со стороны органа зрения\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EОтек век\u003Cbr /\u003EНарушения со стороны сосудов\u003Cbr /\u003E - \u003Cbr /\u003EЧасто\u003Cbr /\u003E - \u003Cbr /\u003EПриливы\u003Cbr /\u003EРедко\u003Cbr /\u003E - \u003Cbr /\u003EГипотензия*, брадикардия*\u003Cbr /\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EЗаложенность носа\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EСухость во рту\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr /\u003E - \u003Cbr /\u003EЧасто\u003Cbr /\u003E - \u003Cbr /\u003EПокраснение, зуд, ощущение жжения кожи, розацеа, побледнение кожи в месте нанесения*\u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EДерматит, раздражение кожи, ощущение тепла, контактный дерматит, аллергический контактный дерматит, сухость кожи, болезненность кожи, кожный дискомфорт, папулезная сыпь, акне, отечность лица*, крапивница*\u003Cbr /\u003EРедко\u003Cbr /\u003E - \u003Cbr /\u003EОтек Квинке*\u003Cbr /\u003EОбщие расстройства и нарушения в месте нанесения\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EЧувство жара, чувство холода в месте нанесения\u003Cbr /\u003E*Данные о побочных действиях, полученные в пострегистрационный период.\u003Cbr /\u003EЕсли любые из указанных в инструкции побочных эффектов усугубляются, или отмечаются любые другие побочные эффекты, не указанные в инструкции, следует немедленно сообщить об этом врачу.\u003Cbr /\u003E"},{"name":"Фармакологическое действие","value":"Бримонидин является высокоселективным агонистом альфа2-адренергических рецепторов: его сродство к альфа2-адренергическим рецепторам в 1000 раз превышает сродство к альфа1-адренергическим рецепторам.\u003Cbr /\u003EНанесение на кожу лица высокоселективного агониста альфа2-адренергических рецепторов приводит к уменьшению эритемы за счет прямой вазоконстрикции мелких кровеносных сосудов дермы.\u003Cbr /\u003E"},{"name":"Фармакологическая группа","value":"альфа-адреномиметики"},{"name":"Форма выпуска","value":"гель"},{"name":"Способ применения/введения","value":"наружный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 30 °С. Не замораживать. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Информация о передозировке бримонидином при наружном применении у взрослых пациентов отсутствует.\u003Cbr /\u003EПри случайном применении препарата внутрь возможны такие явления передозировки агонистами альфа2-рецепторов, как гипотензия, слабость, рвота, сонливость, заторможенность, брадикардия, аритмия, миоз, апноэ, гипотония, гипотермия, угнетение дыхания и судороги.\u003Cbr /\u003EВ ходе клинического исследования было отмечено 2 случая серьезных нежелательных явлений, вызванных случайным проглатыванием Мирвазо Дерм детьми младшего возраста. Наблюдаемые у детей симптомы соответствовали известным симптомам передозировки агонистов альфаг-рецепторов у детей младшего возраста и в течение 24 часов полностью исчезли.\u003Cbr /\u003EЛечение передозировки при приеме препарата внутрь включает поддерживающую и симптоматическую терапию, необходимо поддерживать проходимость дыхательных путей.\u003Cbr /\u003E"},{"name":"Применение при беременности и кормлении грудью","value":"Данные о применении бримонидина при беременности ограничены или отсутствуют.\u003Cbr\u003E Исследования репродуктивной токсичности на животных не выявили прямых или косвенных неблагоприятных эффектов препарата. В качестве меры предосторожности рекомендуется избегать применения препарата Мирвазо Дерм при беременности.\u003Cbr\u003E Неизвестно, выделяются ли бримонидин и его метаболиты с грудным молоком. В связи с этим невозможно исключить риск для новорожденных и грудных детей. Решение о прекращении грудного вскармливания или применения препарата Мирвазо Дерм должно быть принято, принимая во внимание важность применения препарата для матери."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат не влияет или незначительно влияет на способность управлять транспортными средствами или заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr /\u003E- Беременность;\u003Cbr /\u003E- Нарушение функции печени и почек (исследования применения препарата Мирвазо® Дерм у данной категории пациентов не проводились).\u003Cbr /\u003EПрепарат Мирвазо Дерм не следует наносить на раздраженную кожу (в том числе после проведения лазерной терапии) или открытые раны, на область вокруг глаз. В случае выраженного раздражения или аллергии необходимо прервать лечение препаратом.\u003Cbr /\u003EПрепарат Мирвазо Дерм возможно использовать совместно с другими для лечения воспалительных элементов при розацеа, и косметическими средствами. Они могут быть нанесены на кожу только после высыхания препарата Мирвазо Дерм, а не непосредственно перед ним.\u003Cbr /\u003EЭритема и приливы\u003Cbr /\u003EДействие препарата Мирвазо Дерм начинает ослабевать через несколько часов после нанесения. У некоторых пациентов было описано возобновление эритемы и приливов в более тяжелой форме, чем наблюдалось до лечения. Большинство таких случаев отмечалось в течение первых 2 недель после начала лечения.\u003Cbr /\u003EУ некоторых пациентов, получавших терапию Мирвазо Дерм, наблюдались приливы. Время начала их развития варьировало от 30 минут до нескольких часов после нанесения геля.\u003Cbr /\u003EВ большинстве случаев эритема и приливы проходили после отмены препарата.\u003Cbr /\u003EВ случае усугубления эритемы применение Мирвазо Дерм следует приостановить. Симптоматические меры, например, охлаждающие примочки, прием нестероидных противовоспалительных и антигистаминных препаратов, могут облегчить симптомы.\u003Cbr /\u003EПосле возобновления применения препарата Мирвазо Дерм отмечались случаи обострения эритемы и приливов в усугубленной форме. После временного перерыва в лечении возобновление применения Мирвазо Дерм необходимо начинать с пробного нанесения препарата на небольшой участок кожи лица не менее чем за 1 день до перехода к лечению препаратом при его нанесении на всю поверхность кожи лица.\u003Cbr /\u003EСледует строго соблюдать рекомендованную дозу и частоту нанесения: один раз в день, очень тонким слоем.\u003Cbr /\u003EНеобходимо избегать увеличения максимальной суточной дозы и/ или частоты применения, так как безопасность повышенных суточных доз или многократного ежедневного применения не установлена.\u003Cbr /\u003EОдновременное применение с системными агонистами альфа-адренергических рецепторов может усиливать побочные эффекты данного класса лекарственных препаратов у пациентов с:\u003Cbr /\u003E- тяжелыми или неконтролируемыми, или нестабильными сердечно-сосудистыми заболеваниями;\u003Cbr /\u003E- депрессией, недостаточностью мозгового или коронарного кровообращения, болезнью Рейно, ортостатической гипотензией, облитерирующими тромбоангиитами, склеродермией или синдромом Шегрена.\u003Cbr /\u003EВ состав препарата Мирвазо Дерм входит метилпарагидроксибензоат, который может вызвать аллергические реакции (возможно, замедленного типа), а также пропиленгликоль, который может привести к раздражению кожи.\u003Cbr /\u003E"},{"name":"Взаимодействие","value":"Исследований по изучению взаимодействий препарата с другими лекарственными средствами не проводилось.\u003Cbr /\u003EИнгибиторы моноаминоксидазы (МАО) могут теоритически препятствовать усвоению бримонидина и потенциально приводить к увеличению системных побочных действий, таких как гипотензия, а также оказывать влияние на метаболический процесс и усвоение циркулирующих аминов.\u003Cbr /\u003EНеобходимо учитывать возможность добавочного или потенцирующего действия при совместном применении бримонидина с препаратами, угнетающими центральную нервную систему (алкоголь, барбитураты, опиаты, седативные препараты или анестетики).\u003Cbr /\u003EДанные о влиянии бримонидина на уровень циркулирующих катехоламинов отсутствуют. Тем не менее рекомендуется соблюдать осторожность при назначении бримонидина пациентам, получающим препараты, которые способны влиять на метаболизм аминов и повышать их концентрацию в крови, такие как хлорпромазин, метилфенидат, резерпин.\u003Cbr /\u003EРекомендуется соблюдать осторожность в начале лечения или изменении дозы совместно назначаемых системных препаратов (независимо от их лекарственной формы), которые могут взаимодействовать с агонистами альфа-адренергических рецепторов или влиять на их действия, т.е. являются агонистами или антагонистами адренергических рецепторов (например, изопреналин, празозин).\u003Cbr /\u003EУ некоторых пациентов бримонидин способен вызывать клинически незначимое снижение артериального давления, поэтому следует соблюдать осторожность при применении таких препаратов, как гипотензивные средства и/или сердечные гликозиды, одновременно с препаратом Мирвазо Дерм.\u003Cbr /\u003E"},{"name":"Регистрационный номер","value":"ЛП-003563"},{"name":"Дата государственной регистрации","value":"12.04.2016"},{"name":"Владелец регистрационного удостоверения","value":"Galderma"},{"name":"Изготовитель","value":"Galderma"},{"name":"Фасовщик","value":"Galderma"},{"name":"Страна бренда","value":"Швейцария"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Мирвазо дерм"},{"name":"Срок годности","value":"24 мес."}]}],"transitionId":"tr_5"}}}}
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Далее количество наносимого препарата может постепенно увеличиваться, в зависимости от его переносимости и эффективности лечения.\u003Cbr /\u003EПосле применения препарата необходимо обязательно вымыть руки.\u003Cbr /\u003E"},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Наиболее частые нежелательные реакции, включающие покраснение, зуд, приливы и ощущение жжения кожи, были отмечены у пациентов в 1,2-3,3% случаев при проведении клинических исследований. Как правило, это были реакции легкой или средней степени тяжести, которые не приводили к прекращению лечения.\u003Cbr /\u003EСообщалось о случаях обострения симптомов розацеа у пациентов, получавших лечение препаратом Мирвазо Дерм. Учитывая данные всех проведенных клинических исследований, случаи обострения симптомов были отмечены у 16% пациентов.\u003Cbr /\u003EЗначимого различия в профиле безопасности у пожилых пациентов и пациентов в возрасте от 18 до 65 лет выявлено не было.\u003Cbr /\u003EВ пострегистрационный период были отмечены частые случаи усиления покраснения, приливов, ощущения жжения кожи и побледнение кожи в месте нанесения. В пострегистрационный период были также зарегистрированы нечастые случаи головокружения, а также случаи брадикардии и гипотензии (включая ортостатическую гипотензию) с частотой встречаемости \"Редко\", некоторые из которых привели к госпитализации. В некоторых случаях данные нежелательные реакции возникли вследствие нанесения геля Мирвазо Дерм после проведения лазерной терапии.\u003Cbr /\u003EНежелательные реакции, полученные при проведении клинических исследований и в пострегистрационный период (см. Таблицу 1), классифицированы по системам органов и частоте развития. Частоту побочных реакций классифицировали следующим образом: очень часто (≥1/10), часто (≥1/100 до \u003C1/10), нечасто (≥1/1000 до \u003C1/100), редко (≥1/10000 до \u003C1/1000), очень редко (\u003C1/10000), частота неизвестна (невозможно оценить, исходя из имеющихся данных).\u003Cbr /\u003EТаблица 1\u003Cbr /\u003EКласс систем органов\u003Cbr /\u003E - \u003Cbr /\u003EЧастота встречаемости\u003Cbr /\u003E - \u003Cbr /\u003EНежелательные реакции\u003Cbr /\u003EНарушения со стороны нервной системы\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EГоловная боль, парестезии, головокружение*\u003Cbr /\u003EНарушения со стороны органа зрения\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EОтек век\u003Cbr /\u003EНарушения со стороны сосудов\u003Cbr /\u003E - \u003Cbr /\u003EЧасто\u003Cbr /\u003E - \u003Cbr /\u003EПриливы\u003Cbr /\u003EРедко\u003Cbr /\u003E - \u003Cbr /\u003EГипотензия*, брадикардия*\u003Cbr /\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EЗаложенность носа\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EСухость во рту\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr /\u003E - \u003Cbr /\u003EЧасто\u003Cbr /\u003E - \u003Cbr /\u003EПокраснение, зуд, ощущение жжения кожи, розацеа, побледнение кожи в месте нанесения*\u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EДерматит, раздражение кожи, ощущение тепла, контактный дерматит, аллергический контактный дерматит, сухость кожи, болезненность кожи, кожный дискомфорт, папулезная сыпь, акне, отечность лица*, крапивница*\u003Cbr /\u003EРедко\u003Cbr /\u003E - \u003Cbr /\u003EОтек Квинке*\u003Cbr /\u003EОбщие расстройства и нарушения в месте нанесения\u003Cbr /\u003E - \u003Cbr /\u003EНечасто\u003Cbr /\u003E - \u003Cbr /\u003EЧувство жара, чувство холода в месте нанесения\u003Cbr /\u003E*Данные о побочных действиях, полученные в пострегистрационный период.\u003Cbr /\u003EЕсли любые из указанных в инструкции побочных эффектов усугубляются, или отмечаются любые другие побочные эффекты, не указанные в инструкции, следует немедленно сообщить об этом врачу.\u003Cbr /\u003E"},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Бримонидин является высокоселективным агонистом альфа2-адренергических рецепторов: его сродство к альфа2-адренергическим рецепторам в 1000 раз превышает сродство к альфа1-адренергическим рецепторам.\u003Cbr /\u003EНанесение на кожу лица высокоселективного агониста альфа2-адренергических рецепторов приводит к уменьшению эритемы за счет прямой вазоконстрикции мелких кровеносных сосудов дермы.\u003Cbr /\u003E"},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"альфа-адреномиметики"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"гель"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"наружный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"При температуре не выше 30 °С. Не замораживать. Хранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Информация о передозировке бримонидином при наружном применении у взрослых пациентов отсутствует.\u003Cbr /\u003EПри случайном применении препарата внутрь возможны такие явления передозировки агонистами альфа2-рецепторов, как гипотензия, слабость, рвота, сонливость, заторможенность, брадикардия, аритмия, миоз, апноэ, гипотония, гипотермия, угнетение дыхания и судороги.\u003Cbr /\u003EВ ходе клинического исследования было отмечено 2 случая серьезных нежелательных явлений, вызванных случайным проглатыванием Мирвазо Дерм детьми младшего возраста. Наблюдаемые у детей симптомы соответствовали известным симптомам передозировки агонистов альфаг-рецепторов у детей младшего возраста и в течение 24 часов полностью исчезли.\u003Cbr /\u003EЛечение передозировки при приеме препарата внутрь включает поддерживающую и симптоматическую терапию, необходимо поддерживать проходимость дыхательных путей.\u003Cbr /\u003E"},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Данные о применении бримонидина при беременности ограничены или отсутствуют.\u003Cbr\u003E Исследования репродуктивной токсичности на животных не выявили прямых или косвенных неблагоприятных эффектов препарата. В качестве меры предосторожности рекомендуется избегать применения препарата Мирвазо Дерм при беременности.\u003Cbr\u003E Неизвестно, выделяются ли бримонидин и его метаболиты с грудным молоком. В связи с этим невозможно исключить риск для новорожденных и грудных детей. Решение о прекращении грудного вскармливания или применения препарата Мирвазо Дерм должно быть принято, принимая во внимание важность применения препарата для матери."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат не влияет или незначительно влияет на способность управлять транспортными средствами или заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"С осторожностью:\u003Cbr /\u003E- Беременность;\u003Cbr /\u003E- Нарушение функции печени и почек (исследования применения препарата Мирвазо® Дерм у данной категории пациентов не проводились).\u003Cbr /\u003EПрепарат Мирвазо Дерм не следует наносить на раздраженную кожу (в том числе после проведения лазерной терапии) или открытые раны, на область вокруг глаз. В случае выраженного раздражения или аллергии необходимо прервать лечение препаратом.\u003Cbr /\u003EПрепарат Мирвазо Дерм возможно использовать совместно с другими для лечения воспалительных элементов при розацеа, и косметическими средствами. Они могут быть нанесены на кожу только после высыхания препарата Мирвазо Дерм, а не непосредственно перед ним.\u003Cbr /\u003EЭритема и приливы\u003Cbr /\u003EДействие препарата Мирвазо Дерм начинает ослабевать через несколько часов после нанесения. У некоторых пациентов было описано возобновление эритемы и приливов в более тяжелой форме, чем наблюдалось до лечения. Большинство таких случаев отмечалось в течение первых 2 недель после начала лечения.\u003Cbr /\u003EУ некоторых пациентов, получавших терапию Мирвазо Дерм, наблюдались приливы. Время начала их развития варьировало от 30 минут до нескольких часов после нанесения геля.\u003Cbr /\u003EВ большинстве случаев эритема и приливы проходили после отмены препарата.\u003Cbr /\u003EВ случае усугубления эритемы применение Мирвазо Дерм следует приостановить. Симптоматические меры, например, охлаждающие примочки, прием нестероидных противовоспалительных и антигистаминных препаратов, могут облегчить симптомы.\u003Cbr /\u003EПосле возобновления применения препарата Мирвазо Дерм отмечались случаи обострения эритемы и приливов в усугубленной форме. После временного перерыва в лечении возобновление применения Мирвазо Дерм необходимо начинать с пробного нанесения препарата на небольшой участок кожи лица не менее чем за 1 день до перехода к лечению препаратом при его нанесении на всю поверхность кожи лица.\u003Cbr /\u003EСледует строго соблюдать рекомендованную дозу и частоту нанесения: один раз в день, очень тонким слоем.\u003Cbr /\u003EНеобходимо избегать увеличения максимальной суточной дозы и/ или частоты применения, так как безопасность повышенных суточных доз или многократного ежедневного применения не установлена.\u003Cbr /\u003EОдновременное применение с системными агонистами альфа-адренергических рецепторов может усиливать побочные эффекты данного класса лекарственных препаратов у пациентов с:\u003Cbr /\u003E- тяжелыми или неконтролируемыми, или нестабильными сердечно-сосудистыми заболеваниями;\u003Cbr /\u003E- депрессией, недостаточностью мозгового или коронарного кровообращения, болезнью Рейно, ортостатической гипотензией, облитерирующими тромбоангиитами, склеродермией или синдромом Шегрена.\u003Cbr /\u003EВ состав препарата Мирвазо Дерм входит метилпарагидроксибензоат, который может вызвать аллергические реакции (возможно, замедленного типа), а также пропиленгликоль, который может привести к раздражению кожи.\u003Cbr /\u003E"},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Исследований по изучению взаимодействий препарата с другими лекарственными средствами не проводилось.\u003Cbr /\u003EИнгибиторы моноаминоксидазы (МАО) могут теоритически препятствовать усвоению бримонидина и потенциально приводить к увеличению системных побочных действий, таких как гипотензия, а также оказывать влияние на метаболический процесс и усвоение циркулирующих аминов.\u003Cbr /\u003EНеобходимо учитывать возможность добавочного или потенцирующего действия при совместном применении бримонидина с препаратами, угнетающими центральную нервную систему (алкоголь, барбитураты, опиаты, седативные препараты или анестетики).\u003Cbr /\u003EДанные о влиянии бримонидина на уровень циркулирующих катехоламинов отсутствуют. Тем не менее рекомендуется соблюдать осторожность при назначении бримонидина пациентам, получающим препараты, которые способны влиять на метаболизм аминов и повышать их концентрацию в крови, такие как хлорпромазин, метилфенидат, резерпин.\u003Cbr /\u003EРекомендуется соблюдать осторожность в начале лечения или изменении дозы совместно назначаемых системных препаратов (независимо от их лекарственной формы), которые могут взаимодействовать с агонистами альфа-адренергических рецепторов или влиять на их действия, т.е. являются агонистами или антагонистами адренергических рецепторов (например, изопреналин, празозин).\u003Cbr /\u003EУ некоторых пациентов бримонидин способен вызывать клинически незначимое снижение артериального давления, поэтому следует соблюдать осторожность при применении таких препаратов, как гипотензивные средства и/или сердечные гликозиды, одновременно с препаратом Мирвазо Дерм.\u003Cbr /\u003E"},{"description":"","filters":[{"id":16435314,"name":"Регистрационный 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    Цена с картой Яндекс Пэй 1 452 ₽ вместо 1 482
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  • Солантра крем д/нар. прим. туба, 1%, 30 мл, 30 г, 1 шт.
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    Солантра крем д/нар. прим. туба, 1%, 30 мл, 30 г, 1 шт.

    Рейтинг товара: 5 из 5
    на основе 44 оценки
    Цена 2 469 ₽
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  • Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.
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    Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 37 оценок
    Цена 2 246 ₽
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  • Розамет крем, 1%, 25 мл, 25 г
    –1 %
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    Розамет крем, 1%, 25 мл, 25 г

    Рейтинг товара: 4.3 из 5
    на основе 7 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 358 ₽ вместо 362
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  • Набор гелей для коррекции стрий Ферменкол S, Элактин, 15 мл, 2 шт.
    –22 %
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    Набор гелей для коррекции стрий Ферменкол S, Элактин, 15 мл, 2 шт.

    Рейтинг товара: 4 из 5
    на основе 12 оценок
    Цена 4 308 ₽ вместо 5 500
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  • Ферменкол гель косметической линии EnTher, 30 мл, 30 г
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    Ферменкол гель косметической линии EnTher, 30 мл, 30 г

    Рейтинг товара: 4.8 из 5
    на основе 171 оценка
    Цена 1 890 ₽
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  • Вартоцид крем д/нар. прим., 5%, 5 г
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-1koxomvq74z/toggleWishlist":{"skuId":"227812404","productId":1780858021,"offerId":"BDyrJVvEvNV1jAbdo2zU5g","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsJnaq/uPkuBLEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIpfmW0QYQtMjQbBj/3tAHIOXZwQc=","sign":"zKsDK4ypJIFqPrg7HmXl6Y3ztngoauaViSgo8wwUcvE="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-1koxomvq74z/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Вартоцид крем д/нар. прим., 5%, 5 г

    Рейтинг товара: 4.9 из 5
    на основе 8 оценок
    Цена 2 629 ₽
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  • Элидел крем д/нар. прим., 1%, 15 г
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    Элидел крем д/нар. прим., 1%, 15 г

    Рейтинг товара: 4.9 из 5
    на основе 33 оценки
    Цена 1 002 ₽
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  • Протопик мазь д/нар.прим., 0.03%, 30 г
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-snsipkx0j7/toggleWishlist":{"skuId":"228071602","productId":1430987456,"offerId":"HAztyNsf8VYtPth1aR9hsg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsJnaq/uPkuBLEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIwMWsqgUQsrHgbBja2NoIIOXZwQc=","sign":"j1HrCvxi/Ak2Vj+vcycvnSrKE22agX2cHDl3XwSv1BU="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-snsipkx0j7/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Протопик мазь д/нар.прим., 0.03%, 30 г

    Рейтинг товара: 5 из 5
    на основе 17 оценок
    Цена 1 096 ₽
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  • Контрактубекс гель, 20 мл, 20 г
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ld0wx40wbj/toggleWishlist":{"skuId":"265144746","productId":1430987474,"offerId":"QiAahpEONkpPbNrRclZcMg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsJnaq/uPkuBLEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI0sWsqgUQqpO3fhixxNkHIOXZwQc=","sign":"DEGx7A+QwLTW8I+rfr5uk7RiJAz6f/MjKk0zydbVfpw="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ld0wx40wbj/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Контрактубекс гель, 20 мл, 20 г

    Рейтинг товара: 4.9 из 5
    на основе 49 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 946 ₽ вместо 956
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  • Ферменкол гель косметической линии enther туба, 10 мл, 10 г
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0vuk83scc83/toggleWishlist":{"skuId":"265149914","productId":1778172661,"offerId":"lgbOM7NLlq0ATamztOpcEg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsJnaq/uPkuBLEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUI9YXzzwYQ2ru3fhiuoNkHIOXZwQc=","sign":"Pqo60TxACgWp0Ch7rCz+RPyMj6WM47igbN6J0z8YxYs="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0vuk83scc83/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Ферменкол гель косметической линии enther туба, 10 мл, 10 г

    Рейтинг товара: 4.8 из 5
    на основе 24 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 201 ₽ вместо 1 213
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Инструкция

Показания к применению

Лечение эритемы лица при розацеа.

Противопоказания

- Повышенная чувствительность к бримонидину или к любому из вспомогательных веществ;
- Детский возраст до 2 лет (из-за серьезного системного риска);
- Детский возраст от 2 до 18 лет (безопасность и эффективность препарата для данной возрастной категории не установлена);
- Одновременный прием с ингибиторами моноаминоксидазы (МАО) (например, селегилин или моклобемид), и трициклическими (имипрамин) и тетрациклическими (мапротилин, миансерин и миртазапин) антидепрессантами, оказывающими влияние на норадренергическую передачу.

Способ применения и дозы

Только для наружного применения.
Небольшое количество геля тонким слоем наносят на кожу каждой из 5 зон лица (лоб, подбородок, нос, щеки) 1 раз в сутки при наличии эритемы.
При нанесении на кожу гель Мирвазо Дерм необходимо распределять равномерно тонким слоем по лицу, избегая попадания препарата в глаза, на веки, губы, рот и слизистую оболочку носа.
Гель следует наносить только на лицо.
Максимальная рекомендуемая суточная доза препарата составляет 1 г (что примерно соответствует размеру 5 спичечных головок).
Лечение следует начинать с небольшого количества геля (меньше максимальной суточной дозы) продолжительностью в течение не менее одной недели. Далее количество наносимого препарата может постепенно увеличиваться, в зависимости от его переносимости и эффективности лечения.
После применения препарата необходимо обязательно вымыть руки.
Полная инструкция
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Мирвазо Дерм гель д/нар. прим.
Мирвазо Дерм гель д/нар. прим., 0,5%, 30 мл, 30 г
4.6
(10)
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Задать вопрос
Инструкция

3 009 ₽

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4.6
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У продавца:10 оценок·2 отзыва
У всех продавцов:68 оценок·23 отзыва
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user avatar
4 месяца назад • Людмила М.
Достоинства: цена
Недостатки: нет
Комментарий: пользуюсь им уже 3 года, к сожалению, других действенных средств для себя не нашла. это моё спасение при моём ярко выраженном куперозе. очень дорого, конечно, но ничего не поделаешь, здесь вышло дешевле с учётом промо-кода, чем в аптеках города. хватает тюбика на 2-2.5 месяца ежедневного использования.
user avatar
4 месяца назад • Елена Рощупкина
Достоинства: работает как надо, результат уже заметно
Недостатки: цена, очень дорого
Комментарий: косметолог выписал, пришлось приобрести, но чуть худшее финансовое состояние точно ликвидировало возможность приобретения
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    Крем для лица и тела после загара MIXIT "BACK TO SUN" защитный, увлажняющий, с пантенолом и алоэ вера, 150 мл

    Цена 194 ₽ вместо 218
  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
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    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Цена 861 ₽ вместо 1 148
  • Акриол Про крем д/мест. и нар. прим., 2,5%+2,5%, 5 г
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    Акриол Про крем д/мест. и нар. прим., 2,5%+2,5%, 5 г

    Цена 300 ₽ вместо 303
  • Солантра крем д/нар. прим. туба, 1%, 30 мл, 30 г, 1 шт.
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    Солантра крем д/нар. прим. туба, 1%, 30 мл, 30 г, 1 шт.

    Цена 2 469 ₽
  • Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.
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    Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.

    Цена 9 356 ₽ вместо 9 450
  • Кето плюс шампунь, 60 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:995921001_6/content/content/gallery":{"title":"Кето плюс шампунь, 60 мл, 1 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4120567/img_id2239139175136606667.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4120567/img_id2239139175136606667.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4120567/img_id2239139175136606667.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4120567/img_id2239139175136606667.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4120567/img_id2239139175136606667.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4120567/img_id2239139175136606667.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5236204/img_id7821389917234363030.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5236204/img_id7821389917234363030.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5236204/img_id7821389917234363030.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5236204/img_id7821389917234363030.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5236204/img_id7821389917234363030.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5236204/img_id7821389917234363030.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsJnaq/uPkuBLEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCOmY8toDEI2ft34Y/dzQByDh2cEH","sign":"QQNL6KBmfO+B7nuew5WzJICxvGSwTGYJ+39Q16v3d1Y="},"target":"model_card"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:995921001_6/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Кето плюс шампунь, 60 мл, 1 шт.

    Цена 973 ₽ вместо 983
  • Детралекс таб. п/о плен., 500 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1417728424_7/content/content/gallery":{"title":"Детралекс таб. п/о плен., 500 мг, 30 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4012462/img_id232200739689604500.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012462/img_id232200739689604500.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012462/img_id232200739689604500.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012462/img_id232200739689604500.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012462/img_id232200739689604500.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012462/img_id232200739689604500.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 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    Детралекс таб. п/о плен., 500 мг, 30 шт.

    Цена 999 ₽ вместо 1 009
  • Реклама
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  • Фенибут таб., 250 мг, 20 шт.
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    Фенибут таб., 250 мг, 20 шт.

    Цена 110 ₽
  • Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.
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    Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.

    Цена 2 246 ₽
  • ЛимфоТранзит концентрат напитка фл., 100 мл
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • Розамет крем, 1%, 25 мл, 25 г
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    Розамет крем, 1%, 25 мл, 25 г

    Цена 358 ₽ вместо 362
  • Набор гелей для коррекции стрий Ферменкол S, Элактин, 15 мл, 2 шт.
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    Набор гелей для коррекции стрий Ферменкол S, Элактин, 15 мл, 2 шт.

    Цена 4 308 ₽ вместо 5 500
  • Ферменкол гель косметической линии EnTher, 30 мл, 30 г
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    Ферменкол гель косметической линии EnTher, 30 мл, 30 г

    Цена 1 890 ₽
  • Вартоцид крем д/нар. прим., 5%, 5 г
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    Вартоцид крем д/нар. прим., 5%, 5 г

    Цена 2 629 ₽
  • Базирон АС гель д/нар. прим., 5%, 40 мл, 40 г
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    Базирон АС гель д/нар. прим., 5%, 40 мл, 40 г

    Цена 1 286 ₽ вместо 1 299
  • Холисал стомат. гель, 15 г
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    Холисал стомат. гель, 15 г

    Цена 635 ₽ вместо 647
  • Кетоконазол шампунь лекарственный, 2%, 75 г
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    Кетоконазол шампунь лекарственный, 2%, 75 г

    Цена 352 ₽ вместо 360
  • Элидел крем д/нар. прим., 1%, 15 г
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    Элидел крем д/нар. прим., 1%, 15 г

    Цена 1 002 ₽
  • Блефарогель 1 гель для век фл., 15 мл, 15 г, 1 шт.
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    Блефарогель 1 гель для век фл., 15 мл, 15 г, 1 шт.

    Цена 310 ₽ вместо 390
  • Реклама
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  • Метрогил Дента стомат. гель туба, 20 г
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    Метрогил Дента стомат. гель туба, 20 г

    Цена 413 ₽ вместо 417
  • Тербинафин крем, 1%, 15 г, 1 шт.
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    Тербинафин крем, 1%, 15 г, 1 шт.

    Цена 215 ₽ вместо 219
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