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Описание

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Мотилиум экспресс таб. д/рассас., 10 мг, 10 шт.

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5.0
(5)
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Количество штук в упаковке, шт.: 10

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Коротко о товаре

Артикул Маркета
3123919935
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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Специфическим показанием является тошнота и рвота, вызванные агонистами дофамина в случае применения при болезни Паркинсона (такими как леводопа и бромокриптин)."},{"name":"Противопоказания","value":"- повышенная чувствительность к домперидону или любому из компонентов препарата;\u003Cbr\u003E- пролактин-секретирующая опухоль гипофиза (пролактинома);\u003Cbr\u003E- одновременное применение пероральных форм кетоконазола,эритромицина или других мощных ингибиторов изофермента CYP3A4, вызывающих удлинение интервала QT (таких как кларитромицин, интраконазол, флуконазол, позаконазол, ритонавир, саквинавир, амиодарон, телитромицин, телапревир и вориконазол), за исключением апоморфина (см. разделы \"Взаимодействие с другими лекарственными средствами\" и \"Особые указания\");\u003Cbr\u003E- желудочно-кишечные кровотечения, механическая непроходимость или перфорация (т.е. когда стимуляция двигательной функции желудка может быть опаной);\u003Cbr\u003E- нарушения функции печени средней и тяжелой степени;\u003Cbr\u003E- фенилкетонурия;\u003Cbr\u003E- масса тела менее 35 кг;\u003Cbr\u003E- детский возраст до 12 лет, при массе тела \u003C 35 кг."},{"name":"Состав","value":"Действующее вещество (на 1 таблетку): домперидон 10 мг.\u003Cbr\u003E\nВспомогательные вещества (на 1 таблетку): желатин 5,513 мг, маннитол \n4,136 мг, аспартам 0,750 мг, мятная эссенция 0,300 мг, полоксамер 188 1,125 мг."},{"name":"Действующее вещество","value":"Домперидон","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28708879"]}}},{"name":"Способ применения и дозы","value":"Внутрь. Рекомендуется принимать таблетки Мотилиум ЭКСПРЕСС за 15 - 30 минут до еды, в случае приема препарата после еды абсорбция домперидона может замедляться.\u003Cbr\u003EВзрослые и дети старше 12 лет с массой тела 35 кг и более\u003Cbr\u003EПо 1 таблетке (10 мг) З раза в сутки, максимальная суточная доза составляет З таблетки (30 мг).\u003Cbr\u003EДети до 12 лет и с массой тела 35 кг и более\u003Cbr\u003EПо 1 таблетке (10 мг) З раза в сутки, максимальная суточная доза составляет З таблетки (30 мг).\u003Cbr\u003EВ детской практике в основном следует использовать суспензию МОТИЛИУМ.\u003Cbr\u003EОбычно для терапии острой тошноты и рвоты максимальная продолжительность непрерывного приема препарата не должна превышать одну неделю. Если тошнота и рвота продолжаются дольше одной недели, пациенту следует повторно проконсультироваться со своим врачом. По другим показаниям продолжительность терапии составляет 4 недели. Если симптомы не исчезают в течение 4 недель, необходимо провести повторное обследование пациента и оценить необходимость в продолжении терапии.\u003Cbr\u003EПрименение у пациентов с почечной недостаточностью\u003Cbr\u003EПоскольку период полувыведения домперидона при тяжелой почечной недостаточности (при уровне креатинина в сыворотке \u003E 6 мг/100 мл, т. е., \u003E 0,6 ммоль/л) увеличивается, частоту приема Мотилиум ЭКСПРЕСС, таблетки, для рассасывания, следует снизить до 1 или 2 раз в сутки, в зависимости от тяжести недостаточности. Необходимо проводить регулярное обследование пациентов с тяжелой почечной недостаточностью (см. раздел \"Фармакологические свойства\").\u003Cbr\u003EПрименение пациентов с печеночной недостаточностью\u003Cbr\u003EПрименение МОТИЛИУМ ЭКСПРЕСС противопоказано у пациентов со среднетяжелой (7 - 9 по классификации Чайлд-Пью) или тяжелой (\u003E 9 по классификации Чайлд-Пью) печеночной недостаточностью (см. раздел «Противопоказания»). У пациентов с легкой (5 - 6 по классификации Чайлд-Пью) печеночной недостаточностью коррекции дозы препарата не требуется (см. раздел\u003Cbr\u003E«Фармакологические свойства»).\u003Cbr\u003EПоскольку таблетки для рассасывания довольно хрупки, во избежание повреждения их не следует продавливать сквозь фольгу. Для того чтобы достать таблетку из блистера необходимо следующее:\u003Cbr\u003E- возьмите фольгу за край и полностью снимите ее с ячейки, в которой находится таблетка;\u003Cbr\u003E- осторожно надавите снизу;\u003Cbr\u003E- извлеките таблетку из упаковки.\u003Cbr\u003EПоложите таблетку на язык. В течение нескольких секунд она распадется на поверхности языка, ее можно будет проглотить со слюной, не запивая водой."},{"name":"Побочные действия","value":"По данным клинических исследований\u003Cbr\u003E\n\tНежелательные реакции, наблюдавшиеся у ≥ 1% пациентов, принимавших Мотилиум® ЭКСПРЕСС: депрессия, тревога, снижение или отсутствие либидо, головная боль, сонливость, акатизия, сухость в полости рта, диарея, сыпь, зуд, увеличение молочных желез/гинекомастия, боль и чувствительность в области молочных желез, галакторея, нарушения менструального цикла и аменорея, нарушение лактации, астения. \u003Cbr\u003E\n\tНежелательные реакции, наблюдавшиеся у \u003C 1% пациентов, принимавших Мотилиум® ЭКСПРЕСС: гиперчувствительность, крапивница, отек молочных желез, выделения из молочных желез. \u003Cbr\u003E\n\tПриведенные ниже нежелательные эффекты классифицировали следующим образом: очень часто (≥ 10 %), часто (≥ 1 %, но \u003C 10 %), нечасто (≥ 0,1%, но \u003C 1 %), редко (≥ 0,01 %, но \u003C 0,1 %) и очень редко (\u003C 0,01 %), включая отдельные случаи. \u003Cbr\u003E\n\tПо данным спонтанных сообщений о нежелательных явлениях\u003Cbr\u003E\n\tНарушения со стороны иммунной системы. Очень редко: анафилактические реакции, включая анафилактический шок. \u003Cbr\u003E\n\tПсихические нарушения. Очень редко: повышенная возбудимость (преимущественно у новорожденных и детей), нервозность. \u003Cbr\u003E\n\tНарушения со стороны нервной системы. Очень редко: головокружение, экстрапирамидные расстройства и судороги (преимущественно у новорожденных и детей). \u003Cbr\u003E\n\tНарушения со стороны сердечно-сосудистой системы. Очень редко: удлинение интервала QT, желудочковая аритмия*, внезапная коронарная смерть*.\u003Cbr\u003E\n\tНарушения со стороны кожи и подкожных тканей. Очень редко: крапивница, ангионевротический отек. \u003Cbr\u003E\n\tНарушения со стороны почек и мочевыводящих путей. Очень редко: задержка мочи. \u003Cbr\u003E\n\tЛабораторные и инструментальные данные. Очень редко: отклонения лабораторных показателей функции печени, повышение уровня пролактина крови. \u003Cbr\u003E\n\tНежелательные реакции, выявленные в ходе пострегистрационных клинических исследований \u003Cbr\u003E\n\tНарушения со стороны иммунной системы. Частота неизвестна: анафилактические реакции, включая анафилактический шок. \u003Cbr\u003E\n\tПсихические нарушения. Нечасто: повышенная возбудимость (преимущественно у новорожденных и детей), нервозность. \u003Cbr\u003E\n\tНарушения со стороны нервной системы. Часто: головокружение. Редко: судороги (преимущественно у новорожденных и детей). Частота неизвестна: экстрапирамидные расстройства (преимущественно у новорожденных и детей). \u003Cbr\u003E\n\tНарушения со стороны сердечно-сосудистой системы. Частота неизвестна: удлинение интервала QT, желудочковая аритмия*, внезапная коронарная смерть*.\u003Cbr\u003E\n\tНарушения со стороны кожи и подкожных тканей. Частота неизвестна: ангионевротический отек. \u003Cbr\u003E\n\tНарушения со стороны почек и мочевыводящих путей. Нечасто: задержка мочи. \u003Cbr\u003E\n\tЛабораторные и инструментальные данные. Нечасто: отклонения лабораторных показателей функции печени. Редко: повышение уровня пролактина крови. \u003Cbr\u003E\n\t*В некоторых эпидемиологических исследованиях было показано, что применение домперидона может быть связано с повышением риска развития серьезных желудочковых аритмий или внезапной смерти. Риск возникновения данных явлений более вероятен у пациентов старше 60 лет и у пациентов, принимающих препарат в суточной дозе более 30 мг. Рекомендовано применение домперидона в наименьшей эффективной дозе у взрослых и детей. \u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Домперидон – антагонист дофамина, обладающий противорвотными свойствами. Домперидон плохо проникает через гематоэнцефалический барьер. Применение домперидона редко сопровождается экстрапирамидными побочными действиями, особенно у взрослых, но домперидон стимулирует выделение пролактина из гипофиза. Его противорвотное действие может быть обусловлено сочетанием периферического (гастрокинетического) действия и антагонизма к рецепторам дофамина в хеморецепторной триггерной зоне, которая находится за пределами гематоэнцефалического барьера. Исследования на животных и низкие концентрации препарата, выявляемые в головном мозге, свидетельствуют о преимущественно периферическом действии домперидона на дофаминовые рецепторы. \u003Cbr\u003E\nПри применении внутрь домперидон увеличивает продолжительность антральных и дуоденальных сокращений, ускоряет опорожнение желудка и повышает давление сфинктера нижнего отдела пищевода. Домперидон не оказывает действия на желудочную секрецию. \u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"противорвотное средство - дофаминовых рецепторов блокатор центральный"},{"name":"Форма выпуска","value":"таблетки для рассасывания"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"Хранить в сухом месте при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте.\u003Cbr\u003EХранить в оригинальной упаковке."},{"name":"Передозировка","value":"\tСимптомы\u003Cbr\u003E\n\tСлучаи передозировки были отмечены, в основном, у грудных детей и детей старшего возраста. Симптомы передозировки могут включать повышенную возбудимость, изменение сознания, судороги, дезориентацию, сонливость и экстрапирамидные реакции. \u003Cbr\u003E\nЛечение \u003Cbr\u003E\nСпецифического антидота домперидона не существует. В случае передозировки рекомендуется промывание желудка в течение одного часа с момента приема препарата и применение активированного угля. Рекомендуется внимательно следить за состоянием пациента и проводить поддерживающую терапию. Антихолинергические средства и препараты, применяемые для лечения паркинсонизма, могут оказаться эффективными для купирования возникших экстрапирамидных реакций."},{"name":"Применение при беременности и кормлении грудью","value":"Применение при беременности\u003Cbr\u003E\nДанных о применении домперидона во время беременности недостаточно. К настоящему времени не имеется данных о повышении риска пороков развития у людей. Тем не менее, Мотилиум® ЭКСПРЕСС следует назначать при беременности только, если его применение оправдано ожидаемой терапевтической пользой.\u003Cbr\u003E\nПрименение во время лактации\u003Cbr\u003E\nКоличество домперидона, которое может попасть в организм ребенка с грудным молоком, является небольшим.\u003Cbr\u003E\nМаксимальная относительная доза для младенцев (%) оценивается на уровне около 0,1% от дозы, принятой матерью в расчете на массу тела. Неизвестно, оказывает ли этот уровень отрицательное воздействие на новорожденных. В связи с этим при применении препарата Мотилиум® ЭКСПРЕСС в период лактации рекомендуется прекратить грудное вскармливание.\n"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Необходимо соблюдать осторожность при управлении транспортными средствами и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций в связи с риском развития побочных реакций, которые могут влиять на указанные способности."},{"name":"Особые указания","value":"\tПри совместном применении препарата Мотилиум® ЭКСПРЕСС с антацидными или антисекреторными препаратами последние следует принимать после еды, а не до еды, т. е., их не следует принимать одновременно с препаратом Мотилиум® ЭКСПРЕСС. \u003Cbr\u003EМотилиум® ЭКСПРЕСС, таблетки для рассасывания, содержат аспартам, поэтому их не следует использовать у пациентов с гиперфенилаланинемией. \u003Cbr\u003EПрименение у детей \u003Cbr\u003EМотилиум® ЭКСПРЕСС в редких случаях может вызывать неврологические побочные эффекты (см. раздел «Побочные действия»). В связи с этим, следует строго придерживаться рекомендованной дозы (см. раздел «Способ применения и дозы»). У подростков неврологические нежелательные эффекты могут быть вызваны передозировкой препарата, но необходимо принимать во внимание и другие возможные причины таких эффектов. \u003Cbr\u003EПрименение при заболеваниях сердечно-сосудистой системы. \u003Cbr\u003EВ некоторых эпидемиологических исследованиях было показано, что применение домперидона может быть связано с повышением риска серьезных желудочковых аритмий или внезапной коронарной смерти (см. раздел «Побочные действия»). Риск может быть более вероятен у пациентов старше 60 лет и у пациентов, принимающих препарат в суточных дозах более 30 мг. Пациенты старше 60 лет должны принимать препарат Мотилиум® ЭКСПРЕСС с осторожностью. \u003Cbr\u003EДомперидон противопоказан при совместном приеме с лекарственными средствами, удлиняющими интервал QT, за исключением апоморфина. Применение совместно с апоморфином возможно только в том случае, если преимущество совместного применения домперидона с апоморфином превышает риски и только если строго соблюдаются рекомендуемые меры предосторожности для совместного применения препаратов, упомянутые в инструкции по медицинскому применению апоморфина. \u003Cbr\u003EПрименение домперидона и прочих препаратов, приводящих к удлинению интервала QT, не рекомендовано у пациентов с имеющимися нарушениями проводимости (в частности, удлинением интервала QT) и у пациентов с выраженными нарушениями электролитного баланса (гипокалиемия, гиперкалиемия, гипомагниемия) или с брадикардией, или у пациентов с сопутствующими заболеваниями сердца (например, застойная сердечная недостаточность). Как известно, на фоне нарушения электролитного равновесия и брадикардии повышается риск возникновения аритмий. \u003Cbr\u003EВ случае появления признаков или симптомов, которые могут быть связаны с сердечной аритмией, терапию препаратом Мотилиум® ЭКСПРЕСС необходимо прекратить и проконсультироваться у врача. \u003Cbr\u003EПрименение при заболеваниях почек. \u003Cbr\u003EВвиду того, что очень небольшой процент препарата выводится почками в неизмененном виде, то коррекция разовой дозы у больных с почечной недостаточностью не требуется. Однако при повторном назначении Мотилиум® ЭКСПРЕСС частота применения должна быть снижена до одного-двух раз в сутки, в зависимости от тяжести нарушений функции почек (см. раздел «Способ применения и дозы»). При длительной терапии пациенты должны находиться под регулярным наблюдением. \u003Cbr\u003EПотенциал лекарственного взаимодействия \u003Cbr\u003EОсновной путь метаболизма домперидона осуществляется посредством изофермента CYP3A4. In vitro данные и результаты исследований у человека показывают, что сопутствующее применение лекарственных средств, в значительной степени ингибирующих этот фермент, может сопровождаться увеличением концентраций домперидона в плазме. Сочетанное применение домперидона с сильнодействующими ингибиторами изофермента CYP3A4, которые, по полученным данным, вызывают удлинение интервала QT, противопоказано (см. раздел «Противопоказания»). \u003Cbr\u003EНеобходимо соблюдать осторожность при совместном применении домперидона с сильнодействующими ингибиторами изофермента CYP3A4, которые не вызывают удлинение интервала QT (такими как индинавир), и необходим тщательный мониторинг пациентов на предмет возникновения признаков или симптомов нежелательных реакций (см. раздел «Взаимодействие с другими лекарственными средствами»).\n\tНеобходимо соблюдать осторожность при сочетанном применении домперидона с лекарственными средствами, которые, по полученным данным, вызывают удлинение интервала QT, и необходим тщательный мониторинг пациентов на предмет возникновения признаков или симптомов сердечно-сосудистых нежелательных реакций. \u003Cbr\u003EПримеры таких лекарственных средств:\n•\tантиаритмические средства класса IA (например, дизопирамид, хинидин); \u003Cbr\u003E\n•\tантиаритмические средства класса III (например, амиодарон, дофетилид, дронедарон, ибутилид, соталол); \u003Cbr\u003E\n•\tопределенные антипсихотики (например, галоперидол, пимозид, сертиндол); \u003Cbr\u003E\n•\tопределенные антидепрессанты (например, циталопрам, эсциталопрам); \u003Cbr\u003E\n•\tопределенные антибиотики (например, левофлоксацин, моксифлоксацин); \u003Cbr\u003E\n•\tопределенные противогрибковые средства (например, пентамидин); \u003Cbr\u003E\n•\tопределенные противомалярийные средства (например, галофантрин);\n•\tопределенные желудочно-кишечные лекарственные средства (например, доласетрон); \u003Cbr\u003E\n•\tопределенные противоопухолевые лекарственные средства (например, торемифен, вандетаниб); \u003Cbr\u003E\n•\tнекоторые другие лекарственные средства (например, бепридил, метадон). \u003Cbr\u003E\nЕсли лекарственное средство пришло в негодность или истек срок годности, не выбрасывайте его в сточные воды и на улицу. Поместите лекарственное средство в пакет и положите в мусорный контейнер. Эти меры помогут защитить окружающую среду!"},{"name":"Взаимодействие","value":"Антихолинергические препараты могут нейтрализовать действие препарата Мотилиум ЭКСПРЕСС. Пероральная биодоступность препарата Мотилиум ЭКСПРЕСС уменьшается после предшествующего приема циметидина или натрия гидрокарбоната. Не следует принимать антацидные и антисекреторные препараты одновременно с домперидоном, так как они снижают его биодоступность после приема внутрь (см. раздел \"Особые указания\").\u003Cbr\u003EГлавную роль в метаболизме домперидона играет изофермент CYP3A4. Результаты исследований in vitro и клинический опыт показывают, что одновременное применение препаратов, которые значительно ингибируют этот изофермент, может вызывать повышение концентраций домперидона в плазме.\u003Cbr\u003EК числу сильных ингибиторов изофермента CYP3A4 относятся:\u003Cbr\u003EАзольные противогрибковые препараты, такие как флуконазол*, итраконазол, кетоконазол* и вориконазол*;\u003Cbr\u003EАнтибиотики-макролиды например, кларитромицин* и эритромицин*;\u003Cbr\u003EИнгибиторы протеазы ВИЧ, например, ампренавир, атазанавир, фосампренавир, индинавир, нелфинавир, ритонавир и саквинавир;\u003Cbr\u003EАнтагонисты кальция, такие как дилтиазем и верапамил;\u003Cbr\u003EАмиодарон*;\u003Cbr\u003EАпрепитант;\u003Cbr\u003EНефазодон;\u003Cbr\u003EТелитромицин*.\u003Cbr\u003E(Препараты, помеченные звездочкой, помимо прочего, удлиняют интервал QT (см. раздел \"Противопоказания\").\u003Cbr\u003EВ ряде исследований фармакокинетических и фармакодинамических взаимодействий домперидона с пероральным кетоконазолом и пероральном эритромицином у здоровых добровольцев было показано, что эти препараты значительно ингибируют первичный метаболизм домперидона, осуществляемый изоферментом CYP3A4.\u003Cbr\u003EПри одновременном приеме 10 мг домперидона 4 раза в сутки и 200 мг кетоконазола 2 раза в сутки отмечалось удлинение интервала QT в среднем на 9,8 мс в течение всего периода наблюдения, в отдельные моменты изменения варьировались от 1,2 до 17,5 мс. При одновременном приеме 10 мг домперидона 4 раза в сутки и 500 мг эритромицина 3 раза в сутки отмечалось удлинение интервала QT в среднем на 9,9 мс в течение всего периода наблюдения, в отдельные моменты изменения варьировали от 1,6 до 14,3 мс. В каждом из этих исследований Сmах и AUC домперидона увеличивались примерно в три раза (см. раздел \"Противопоказания\").\u003Cbr\u003EВ настоящее время неизвестно, какой вклад в изменение интервала QTс вносят повышенные концентрации домперидона в плазме.\u003Cbr\u003EВ этих исследованиях монотерапия домперидоном (10 мг четыре раза в сутки) привела к удлинению интервала QT на 1,6 мс (исследование кетоконазола) и на 2,5 мс (исследование эритромицина), тогда как монотерапия кетоконазолом (200 мг два раза в сутки) и монотерапия эритромицином (500 мг три раза в сутки) привели к удлинению интервала QT на 3,8 и 4,9 мс соответственно, в течение всего периода наблюдения.\u003Cbr\u003EВ другом исследовании с применением многократных доз у здоровых добровольцев не было обнаружено значимого удлинения интервала QT во время стационарной монотерапии домперидоном (40 мг четыре раза в сутки, общая суточная доза 160 мг, что существенно превышает рекомендуемую максимальную суточную дозу). При этом концентрации домперидона в плазме были сходны с таковыми в исследованиях взаимодействия домперидона с другими препаратами. Ввиду того, что Мотилиум ЭКСПРЕСС обладает гастрокинетическим действием, теоретически он мог бы влиять на абсорбцию одновременно применяющихся пероральных препаратов - в частности, препаратов с пролонгированным высвобождением активного вещества, или препаратов, покрытых кишечнорастворимой оболочкой. Однако применение домперидона у пациентов на фоне приема парацетамола или дигоксина не влияло на уровень этих препаратов в крови.\u003Cbr\u003EМотилиум ЭКСПРЕСС можно принимать одновременно с:\u003Cbr\u003Eнейролептиками, действие которых он не усиливает;\u003Cbr\u003Eс агонистами дофаминергических рецепторов (бромокриптин, леводопа), поскольку он угнетает их нежелательные периферические эффекты (такие как нарушения пищеварения, тошнота и рвота), не влияя при этом на их центральные эффекты.\u003Cbr\u003EПрименение совместно с апоморфином возможно только в том случае, если преимущество совместного применения превышает риски и только если строго соблюдаются рекомендуемые меры предосторожности для совместного применения препаратов.\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"П N011655/01"},{"name":"Дата государственной регистрации","value":"22.07.2019"},{"name":"Владелец регистрационного удостоверения","value":"Johnson & Johnson","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:10789460"]}}},{"name":"Изготовитель","value":"Catalent U.K. Swindon Zydis Ltd"},{"name":"Страна-производитель","value":"Великобритания"},{"name":"Название препарата","value":"Мотилиум","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18008590"]}}},{"name":"Срок годности","value":"23 мес."}]}},"fullSpecsGrouped":{"5193186699522982542":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"желудок, желудочно-кишечный тракт, пищеварительная система"},{"name":"Назначение","value":"диспепсические явления, изжога, метеоризм, рвота, рефлюкс-эзофагит, тошнота, тяжесть в эпигастральной области, чувство тяжести в животе"},{"name":"Показания к применению","value":"а) Комплекс диспептических симптомов, часто ассоциирующийся с замедленным опорожнением желудка, желудочно-пищеводным: рефлюксом, эзофагитом:\u003Cbr\u003E- чувство переполнения в эпигастрии, ощущение вздутия живота, боль в верхней части живота;\u003Cbr\u003E- отрыжка, метеоризм;\u003Cbr\u003E- тошнота, рвота;\u003Cbr\u003E- изжога, отрыжка.\u003Cbr\u003Eб) Тошнота и рвота функционального, органического, инфекционного происхождения, а также вызванные радиотерапией, лекарственной терапией или нарушением диеты. Специфическим показанием является тошнота и рвота, вызванные агонистами дофамина в случае применения при болезни Паркинсона (такими как леводопа и бромокриптин)."},{"name":"Противопоказания","value":"- повышенная чувствительность к домперидону или любому из компонентов препарата;\u003Cbr\u003E- пролактин-секретирующая опухоль гипофиза (пролактинома);\u003Cbr\u003E- одновременное применение пероральных форм кетоконазола,эритромицина или других мощных ингибиторов изофермента CYP3A4, вызывающих удлинение интервала QT (таких как кларитромицин, интраконазол, флуконазол, позаконазол, ритонавир, саквинавир, амиодарон, телитромицин, телапревир и вориконазол), за исключением апоморфина (см. разделы \"Взаимодействие с другими лекарственными средствами\" и \"Особые указания\");\u003Cbr\u003E- желудочно-кишечные кровотечения, механическая непроходимость или перфорация (т.е. когда стимуляция двигательной функции желудка может быть опаной);\u003Cbr\u003E- нарушения функции печени средней и тяжелой степени;\u003Cbr\u003E- фенилкетонурия;\u003Cbr\u003E- масса тела менее 35 кг;\u003Cbr\u003E- детский возраст до 12 лет, при массе тела \u003C 35 кг."},{"name":"Состав","value":"Действующее вещество (на 1 таблетку): домперидон 10 мг.\u003Cbr\u003E\nВспомогательные вещества (на 1 таблетку): желатин 5,513 мг, маннитол \n4,136 мг, аспартам 0,750 мг, мятная эссенция 0,300 мг, полоксамер 188 1,125 мг."},{"name":"Действующее вещество","value":"Домперидон"},{"name":"Способ применения и дозы","value":"Внутрь. Рекомендуется принимать таблетки Мотилиум ЭКСПРЕСС за 15 - 30 минут до еды, в случае приема препарата после еды абсорбция домперидона может замедляться.\u003Cbr\u003EВзрослые и дети старше 12 лет с массой тела 35 кг и более\u003Cbr\u003EПо 1 таблетке (10 мг) З раза в сутки, максимальная суточная доза составляет З таблетки (30 мг).\u003Cbr\u003EДети до 12 лет и с массой тела 35 кг и более\u003Cbr\u003EПо 1 таблетке (10 мг) З раза в сутки, максимальная суточная доза составляет З таблетки (30 мг).\u003Cbr\u003EВ детской практике в основном следует использовать суспензию МОТИЛИУМ.\u003Cbr\u003EОбычно для терапии острой тошноты и рвоты максимальная продолжительность непрерывного приема препарата не должна превышать одну неделю. Если тошнота и рвота продолжаются дольше одной недели, пациенту следует повторно проконсультироваться со своим врачом. По другим показаниям продолжительность терапии составляет 4 недели. Если симптомы не исчезают в течение 4 недель, необходимо провести повторное обследование пациента и оценить необходимость в продолжении терапии.\u003Cbr\u003EПрименение у пациентов с почечной недостаточностью\u003Cbr\u003EПоскольку период полувыведения домперидона при тяжелой почечной недостаточности (при уровне креатинина в сыворотке \u003E 6 мг/100 мл, т. е., \u003E 0,6 ммоль/л) увеличивается, частоту приема Мотилиум ЭКСПРЕСС, таблетки, для рассасывания, следует снизить до 1 или 2 раз в сутки, в зависимости от тяжести недостаточности. Необходимо проводить регулярное обследование пациентов с тяжелой почечной недостаточностью (см. раздел \"Фармакологические свойства\").\u003Cbr\u003EПрименение пациентов с печеночной недостаточностью\u003Cbr\u003EПрименение МОТИЛИУМ ЭКСПРЕСС противопоказано у пациентов со среднетяжелой (7 - 9 по классификации Чайлд-Пью) или тяжелой (\u003E 9 по классификации Чайлд-Пью) печеночной недостаточностью (см. раздел «Противопоказания»). У пациентов с легкой (5 - 6 по классификации Чайлд-Пью) печеночной недостаточностью коррекции дозы препарата не требуется (см. раздел\u003Cbr\u003E«Фармакологические свойства»).\u003Cbr\u003EПоскольку таблетки для рассасывания довольно хрупки, во избежание повреждения их не следует продавливать сквозь фольгу. Для того чтобы достать таблетку из блистера необходимо следующее:\u003Cbr\u003E- возьмите фольгу за край и полностью снимите ее с ячейки, в которой находится таблетка;\u003Cbr\u003E- осторожно надавите снизу;\u003Cbr\u003E- извлеките таблетку из упаковки.\u003Cbr\u003EПоложите таблетку на язык. В течение нескольких секунд она распадется на поверхности языка, ее можно будет проглотить со слюной, не запивая водой."},{"name":"Побочные действия","value":"По данным клинических исследований\u003Cbr\u003E\n\tНежелательные реакции, наблюдавшиеся у ≥ 1% пациентов, принимавших Мотилиум® ЭКСПРЕСС: депрессия, тревога, снижение или отсутствие либидо, головная боль, сонливость, акатизия, сухость в полости рта, диарея, сыпь, зуд, увеличение молочных желез/гинекомастия, боль и чувствительность в области молочных желез, галакторея, нарушения менструального цикла и аменорея, нарушение лактации, астения. \u003Cbr\u003E\n\tНежелательные реакции, наблюдавшиеся у \u003C 1% пациентов, принимавших Мотилиум® ЭКСПРЕСС: гиперчувствительность, крапивница, отек молочных желез, выделения из молочных желез. \u003Cbr\u003E\n\tПриведенные ниже нежелательные эффекты классифицировали следующим образом: очень часто (≥ 10 %), часто (≥ 1 %, но \u003C 10 %), нечасто (≥ 0,1%, но \u003C 1 %), редко (≥ 0,01 %, но \u003C 0,1 %) и очень редко (\u003C 0,01 %), включая отдельные случаи. \u003Cbr\u003E\n\tПо данным спонтанных сообщений о нежелательных явлениях\u003Cbr\u003E\n\tНарушения со стороны иммунной системы. Очень редко: анафилактические реакции, включая анафилактический шок. \u003Cbr\u003E\n\tПсихические нарушения. Очень редко: повышенная возбудимость (преимущественно у новорожденных и детей), нервозность. \u003Cbr\u003E\n\tНарушения со стороны нервной системы. Очень редко: головокружение, экстрапирамидные расстройства и судороги (преимущественно у новорожденных и детей). \u003Cbr\u003E\n\tНарушения со стороны сердечно-сосудистой системы. Очень редко: удлинение интервала QT, желудочковая аритмия*, внезапная коронарная смерть*.\u003Cbr\u003E\n\tНарушения со стороны кожи и подкожных тканей. Очень редко: крапивница, ангионевротический отек. \u003Cbr\u003E\n\tНарушения со стороны почек и мочевыводящих путей. Очень редко: задержка мочи. \u003Cbr\u003E\n\tЛабораторные и инструментальные данные. Очень редко: отклонения лабораторных показателей функции печени, повышение уровня пролактина крови. \u003Cbr\u003E\n\tНежелательные реакции, выявленные в ходе пострегистрационных клинических исследований \u003Cbr\u003E\n\tНарушения со стороны иммунной системы. Частота неизвестна: анафилактические реакции, включая анафилактический шок. \u003Cbr\u003E\n\tПсихические нарушения. Нечасто: повышенная возбудимость (преимущественно у новорожденных и детей), нервозность. \u003Cbr\u003E\n\tНарушения со стороны нервной системы. Часто: головокружение. Редко: судороги (преимущественно у новорожденных и детей). Частота неизвестна: экстрапирамидные расстройства (преимущественно у новорожденных и детей). \u003Cbr\u003E\n\tНарушения со стороны сердечно-сосудистой системы. Частота неизвестна: удлинение интервала QT, желудочковая аритмия*, внезапная коронарная смерть*.\u003Cbr\u003E\n\tНарушения со стороны кожи и подкожных тканей. Частота неизвестна: ангионевротический отек. \u003Cbr\u003E\n\tНарушения со стороны почек и мочевыводящих путей. Нечасто: задержка мочи. \u003Cbr\u003E\n\tЛабораторные и инструментальные данные. Нечасто: отклонения лабораторных показателей функции печени. Редко: повышение уровня пролактина крови. \u003Cbr\u003E\n\t*В некоторых эпидемиологических исследованиях было показано, что применение домперидона может быть связано с повышением риска развития серьезных желудочковых аритмий или внезапной смерти. Риск возникновения данных явлений более вероятен у пациентов старше 60 лет и у пациентов, принимающих препарат в суточной дозе более 30 мг. Рекомендовано применение домперидона в наименьшей эффективной дозе у взрослых и детей. \u003Cbr\u003E"},{"name":"Фармакологическое действие","value":"Домперидон – антагонист дофамина, обладающий противорвотными свойствами. Домперидон плохо проникает через гематоэнцефалический барьер. Применение домперидона редко сопровождается экстрапирамидными побочными действиями, особенно у взрослых, но домперидон стимулирует выделение пролактина из гипофиза. Его противорвотное действие может быть обусловлено сочетанием периферического (гастрокинетического) действия и антагонизма к рецепторам дофамина в хеморецепторной триггерной зоне, которая находится за пределами гематоэнцефалического барьера. Исследования на животных и низкие концентрации препарата, выявляемые в головном мозге, свидетельствуют о преимущественно периферическом действии домперидона на дофаминовые рецепторы. \u003Cbr\u003E\nПри применении внутрь домперидон увеличивает продолжительность антральных и дуоденальных сокращений, ускоряет опорожнение желудка и повышает давление сфинктера нижнего отдела пищевода. Домперидон не оказывает действия на желудочную секрецию. \u003Cbr\u003E"},{"name":"Фармакологическая группа","value":"противорвотное средство - дофаминовых рецепторов блокатор центральный"},{"name":"Форма выпуска","value":"таблетки для рассасывания"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить в сухом месте при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте.\u003Cbr\u003EХранить в оригинальной упаковке."},{"name":"Передозировка","value":"\tСимптомы\u003Cbr\u003E\n\tСлучаи передозировки были отмечены, в основном, у грудных детей и детей старшего возраста. Симптомы передозировки могут включать повышенную возбудимость, изменение сознания, судороги, дезориентацию, сонливость и экстрапирамидные реакции. \u003Cbr\u003E\nЛечение \u003Cbr\u003E\nСпецифического антидота домперидона не существует. В случае передозировки рекомендуется промывание желудка в течение одного часа с момента приема препарата и применение активированного угля. Рекомендуется внимательно следить за состоянием пациента и проводить поддерживающую терапию. Антихолинергические средства и препараты, применяемые для лечения паркинсонизма, могут оказаться эффективными для купирования возникших экстрапирамидных реакций."},{"name":"Применение при беременности и кормлении грудью","value":"Применение при беременности\u003Cbr\u003E\nДанных о применении домперидона во время беременности недостаточно. К настоящему времени не имеется данных о повышении риска пороков развития у людей. Тем не менее, Мотилиум® ЭКСПРЕСС следует назначать при беременности только, если его применение оправдано ожидаемой терапевтической пользой.\u003Cbr\u003E\nПрименение во время лактации\u003Cbr\u003E\nКоличество домперидона, которое может попасть в организм ребенка с грудным молоком, является небольшим.\u003Cbr\u003E\nМаксимальная относительная доза для младенцев (%) оценивается на уровне около 0,1% от дозы, принятой матерью в расчете на массу тела. Неизвестно, оказывает ли этот уровень отрицательное воздействие на новорожденных. В связи с этим при применении препарата Мотилиум® ЭКСПРЕСС в период лактации рекомендуется прекратить грудное вскармливание.\n"},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Необходимо соблюдать осторожность при управлении транспортными средствами и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций в связи с риском развития побочных реакций, которые могут влиять на указанные способности."},{"name":"Особые указания","value":"\tПри совместном применении препарата Мотилиум® ЭКСПРЕСС с антацидными или антисекреторными препаратами последние следует принимать после еды, а не до еды, т. е., их не следует принимать одновременно с препаратом Мотилиум® ЭКСПРЕСС. \u003Cbr\u003EМотилиум® ЭКСПРЕСС, таблетки для рассасывания, содержат аспартам, поэтому их не следует использовать у пациентов с гиперфенилаланинемией. \u003Cbr\u003EПрименение у детей \u003Cbr\u003EМотилиум® ЭКСПРЕСС в редких случаях может вызывать неврологические побочные эффекты (см. раздел «Побочные действия»). В связи с этим, следует строго придерживаться рекомендованной дозы (см. раздел «Способ применения и дозы»). У подростков неврологические нежелательные эффекты могут быть вызваны передозировкой препарата, но необходимо принимать во внимание и другие возможные причины таких эффектов. \u003Cbr\u003EПрименение при заболеваниях сердечно-сосудистой системы. \u003Cbr\u003EВ некоторых эпидемиологических исследованиях было показано, что применение домперидона может быть связано с повышением риска серьезных желудочковых аритмий или внезапной коронарной смерти (см. раздел «Побочные действия»). Риск может быть более вероятен у пациентов старше 60 лет и у пациентов, принимающих препарат в суточных дозах более 30 мг. Пациенты старше 60 лет должны принимать препарат Мотилиум® ЭКСПРЕСС с осторожностью. \u003Cbr\u003EДомперидон противопоказан при совместном приеме с лекарственными средствами, удлиняющими интервал QT, за исключением апоморфина. Применение совместно с апоморфином возможно только в том случае, если преимущество совместного применения домперидона с апоморфином превышает риски и только если строго соблюдаются рекомендуемые меры предосторожности для совместного применения препаратов, упомянутые в инструкции по медицинскому применению апоморфина. \u003Cbr\u003EПрименение домперидона и прочих препаратов, приводящих к удлинению интервала QT, не рекомендовано у пациентов с имеющимися нарушениями проводимости (в частности, удлинением интервала QT) и у пациентов с выраженными нарушениями электролитного баланса (гипокалиемия, гиперкалиемия, гипомагниемия) или с брадикардией, или у пациентов с сопутствующими заболеваниями сердца (например, застойная сердечная недостаточность). Как известно, на фоне нарушения электролитного равновесия и брадикардии повышается риск возникновения аритмий. \u003Cbr\u003EВ случае появления признаков или симптомов, которые могут быть связаны с сердечной аритмией, терапию препаратом Мотилиум® ЭКСПРЕСС необходимо прекратить и проконсультироваться у врача. \u003Cbr\u003EПрименение при заболеваниях почек. \u003Cbr\u003EВвиду того, что очень небольшой процент препарата выводится почками в неизмененном виде, то коррекция разовой дозы у больных с почечной недостаточностью не требуется. Однако при повторном назначении Мотилиум® ЭКСПРЕСС частота применения должна быть снижена до одного-двух раз в сутки, в зависимости от тяжести нарушений функции почек (см. раздел «Способ применения и дозы»). При длительной терапии пациенты должны находиться под регулярным наблюдением. \u003Cbr\u003EПотенциал лекарственного взаимодействия \u003Cbr\u003EОсновной путь метаболизма домперидона осуществляется посредством изофермента CYP3A4. In vitro данные и результаты исследований у человека показывают, что сопутствующее применение лекарственных средств, в значительной степени ингибирующих этот фермент, может сопровождаться увеличением концентраций домперидона в плазме. Сочетанное применение домперидона с сильнодействующими ингибиторами изофермента CYP3A4, которые, по полученным данным, вызывают удлинение интервала QT, противопоказано (см. раздел «Противопоказания»). \u003Cbr\u003EНеобходимо соблюдать осторожность при совместном применении домперидона с сильнодействующими ингибиторами изофермента CYP3A4, которые не вызывают удлинение интервала QT (такими как индинавир), и необходим тщательный мониторинг пациентов на предмет возникновения признаков или симптомов нежелательных реакций (см. раздел «Взаимодействие с другими лекарственными средствами»).\n\tНеобходимо соблюдать осторожность при сочетанном применении домперидона с лекарственными средствами, которые, по полученным данным, вызывают удлинение интервала QT, и необходим тщательный мониторинг пациентов на предмет возникновения признаков или симптомов сердечно-сосудистых нежелательных реакций. \u003Cbr\u003EПримеры таких лекарственных средств:\n•\tантиаритмические средства класса IA (например, дизопирамид, хинидин); \u003Cbr\u003E\n•\tантиаритмические средства класса III (например, амиодарон, дофетилид, дронедарон, ибутилид, соталол); \u003Cbr\u003E\n•\tопределенные антипсихотики (например, галоперидол, пимозид, сертиндол); \u003Cbr\u003E\n•\tопределенные антидепрессанты (например, циталопрам, эсциталопрам); \u003Cbr\u003E\n•\tопределенные антибиотики (например, левофлоксацин, моксифлоксацин); \u003Cbr\u003E\n•\tопределенные противогрибковые средства (например, пентамидин); \u003Cbr\u003E\n•\tопределенные противомалярийные средства (например, галофантрин);\n•\tопределенные желудочно-кишечные лекарственные средства (например, доласетрон); \u003Cbr\u003E\n•\tопределенные противоопухолевые лекарственные средства (например, торемифен, вандетаниб); \u003Cbr\u003E\n•\tнекоторые другие лекарственные средства (например, бепридил, метадон). \u003Cbr\u003E\nЕсли лекарственное средство пришло в негодность или истек срок годности, не выбрасывайте его в сточные воды и на улицу. Поместите лекарственное средство в пакет и положите в мусорный контейнер. Эти меры помогут защитить окружающую среду!"},{"name":"Взаимодействие","value":"Антихолинергические препараты могут нейтрализовать действие препарата Мотилиум ЭКСПРЕСС. Пероральная биодоступность препарата Мотилиум ЭКСПРЕСС уменьшается после предшествующего приема циметидина или натрия гидрокарбоната. Не следует принимать антацидные и антисекреторные препараты одновременно с домперидоном, так как они снижают его биодоступность после приема внутрь (см. раздел \"Особые указания\").\u003Cbr\u003EГлавную роль в метаболизме домперидона играет изофермент CYP3A4. Результаты исследований in vitro и клинический опыт показывают, что одновременное применение препаратов, которые значительно ингибируют этот изофермент, может вызывать повышение концентраций домперидона в плазме.\u003Cbr\u003EК числу сильных ингибиторов изофермента CYP3A4 относятся:\u003Cbr\u003EАзольные противогрибковые препараты, такие как флуконазол*, итраконазол, кетоконазол* и вориконазол*;\u003Cbr\u003EАнтибиотики-макролиды например, кларитромицин* и эритромицин*;\u003Cbr\u003EИнгибиторы протеазы ВИЧ, например, ампренавир, атазанавир, фосампренавир, индинавир, нелфинавир, ритонавир и саквинавир;\u003Cbr\u003EАнтагонисты кальция, такие как дилтиазем и верапамил;\u003Cbr\u003EАмиодарон*;\u003Cbr\u003EАпрепитант;\u003Cbr\u003EНефазодон;\u003Cbr\u003EТелитромицин*.\u003Cbr\u003E(Препараты, помеченные звездочкой, помимо прочего, удлиняют интервал QT (см. раздел \"Противопоказания\").\u003Cbr\u003EВ ряде исследований фармакокинетических и фармакодинамических взаимодействий домперидона с пероральным кетоконазолом и пероральном эритромицином у здоровых добровольцев было показано, что эти препараты значительно ингибируют первичный метаболизм домперидона, осуществляемый изоферментом CYP3A4.\u003Cbr\u003EПри одновременном приеме 10 мг домперидона 4 раза в сутки и 200 мг кетоконазола 2 раза в сутки отмечалось удлинение интервала QT в среднем на 9,8 мс в течение всего периода наблюдения, в отдельные моменты изменения варьировались от 1,2 до 17,5 мс. При одновременном приеме 10 мг домперидона 4 раза в сутки и 500 мг эритромицина 3 раза в сутки отмечалось удлинение интервала QT в среднем на 9,9 мс в течение всего периода наблюдения, в отдельные моменты изменения варьировали от 1,6 до 14,3 мс. В каждом из этих исследований Сmах и AUC домперидона увеличивались примерно в три раза (см. раздел \"Противопоказания\").\u003Cbr\u003EВ настоящее время неизвестно, какой вклад в изменение интервала QTс вносят повышенные концентрации домперидона в плазме.\u003Cbr\u003EВ этих исследованиях монотерапия домперидоном (10 мг четыре раза в сутки) привела к удлинению интервала QT на 1,6 мс (исследование кетоконазола) и на 2,5 мс (исследование эритромицина), тогда как монотерапия кетоконазолом (200 мг два раза в сутки) и монотерапия эритромицином (500 мг три раза в сутки) привели к удлинению интервала QT на 3,8 и 4,9 мс соответственно, в течение всего периода наблюдения.\u003Cbr\u003EВ другом исследовании с применением многократных доз у здоровых добровольцев не было обнаружено значимого удлинения интервала QT во время стационарной монотерапии домперидоном (40 мг четыре раза в сутки, общая суточная доза 160 мг, что существенно превышает рекомендуемую максимальную суточную дозу). При этом концентрации домперидона в плазме были сходны с таковыми в исследованиях взаимодействия домперидона с другими препаратами. Ввиду того, что Мотилиум ЭКСПРЕСС обладает гастрокинетическим действием, теоретически он мог бы влиять на абсорбцию одновременно применяющихся пероральных препаратов - в частности, препаратов с пролонгированным высвобождением активного вещества, или препаратов, покрытых кишечнорастворимой оболочкой. Однако применение домперидона у пациентов на фоне приема парацетамола или дигоксина не влияло на уровень этих препаратов в крови.\u003Cbr\u003EМотилиум ЭКСПРЕСС можно принимать одновременно с:\u003Cbr\u003Eнейролептиками, действие которых он не усиливает;\u003Cbr\u003Eс агонистами дофаминергических рецепторов (бромокриптин, леводопа), поскольку он угнетает их нежелательные периферические эффекты (такие как нарушения пищеварения, тошнота и рвота), не влияя при этом на их центральные эффекты.\u003Cbr\u003EПрименение совместно с апоморфином возможно только в том случае, если преимущество совместного применения превышает риски и только если строго соблюдаются рекомендуемые меры предосторожности для совместного применения препаратов.\u003Cbr\u003E"},{"name":"Регистрационный номер","value":"П N011655/01"},{"name":"Дата государственной регистрации","value":"22.07.2019"},{"name":"Владелец регистрационного удостоверения","value":"Johnson & Johnson"},{"name":"Изготовитель","value":"Catalent U.K. Swindon Zydis Ltd"},{"name":"Страна-производитель","value":"Великобритания"},{"name":"Название препарата","value":"Мотилиум"},{"name":"Срок годности","value":"23 мес."}]}],"transitionId":"tr_8021574950691323391"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена с картой Яндекс Пэй 886 ₽ вместо 895
    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  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
    ВАМ–32 %
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    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Рейтинг товара: 4.5 из 5
    на основе 1313 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 706 ₽ вместо 713
    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фактор таб. п/о, 1.2 г, 60 шт., 1 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  • Регидрон Био пор. д/приг. р-ра д/вн. приема саше, 6.4 г, 5 шт.
    –2 %
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    Регидрон Био пор. д/приг. р-ра д/вн. приема саше, 6.4 г, 5 шт.

    Рейтинг товара: 4.8 из 5
    на основе 4 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 644 ₽ вместо 658
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  • Фитомуцил норм пор. саше, 5 г, 10 шт., нейтральный, 1 уп.
    –1 %
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    Фитомуцил норм пор. саше, 5 г, 10 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 48 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 464 ₽ вместо 469
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  • Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.
    –8 %
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    Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 771 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 569 ₽ вместо 575
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  • ЛактоБаланс капс., 7 шт.
    ВАМ–17 %
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    ЛактоБаланс капс., 7 шт.

    Рейтинг товара: 4.8 из 5
    на основе 266 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 562 ₽ вместо 574
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  • Бак-сет форте капс., 10 шт., нейтральный, 1 уп.
    –1 %
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    Бак-сет форте капс., 10 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 165 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 455 ₽ вместо 460
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  • Фитолакс таб. жев., 20 шт., абрикос, 1 уп.
    –2 %
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    Фитолакс таб. жев., 20 шт., абрикос, 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 35 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 350 ₽ вместо 358
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  • Стимбифид таб., 100 г, 80 шт., нейтральный, 1 уп.
    –2 %
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    Стимбифид таб., 100 г, 80 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 7 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 864 ₽ вместо 882
    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  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
    –46 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-81kgwvj9k1b/toggleWishlist":{"skuId":"101370161396","productId":997279548,"offerId":"DNTgLfhb2SFZHNJpMz1ccg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgsQo/rBodj3x8SGARIxCi9Db21wZXRpdGl2ZUFuYWxvZ3NfTWFya2V0TW9kZWxDYXJkX0Zyb250U25pcHBldDIXCLyOxdsDEPTRh9H5Ahj03/kHINrZwQc=","sign":"bj8oHCEB8x/3jmaVn5kvPnKplTMrdRmUWOV0exTkM7I="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-81kgwvj9k1b/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 594 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 881 ₽ вместо 1 900
    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  • Зостерин Ультра 60% пор., 0.5 г, 5 шт., нейтральный, 1 уп.
    –1 %
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    Зостерин Ультра 60% пор., 0.5 г, 5 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 111 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 393 ₽ вместо 397
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Инструкция

Показания к применению

а) Комплекс диспептических симптомов, часто ассоциирующийся с замедленным опорожнением желудка, желудочно-пищеводным: рефлюксом, эзофагитом:
- чувство переполнения в эпигастрии, ощущение вздутия живота, боль в верхней части живота;
- отрыжка, метеоризм;
- тошнота, рвота;
- изжога, отрыжка.
б) Тошнота и рвота функционального, органического, инфекционного происхождения, а также вызванные радиотерапией, лекарственной терапией или нарушением диеты. Специфическим показанием является тошнота и рвота, вызванные агонистами дофамина в случае применения при болезни Паркинсона (такими как леводопа и бромокриптин).

Противопоказания

- повышенная чувствительность к домперидону или любому из компонентов препарата;
- пролактин-секретирующая опухоль гипофиза (пролактинома);
- одновременное применение пероральных форм кетоконазола,эритромицина или других мощных ингибиторов изофермента CYP3A4, вызывающих удлинение интервала QT (таких как кларитромицин, интраконазол, флуконазол, позаконазол, ритонавир, саквинавир, амиодарон, телитромицин, телапревир и вориконазол), за исключением апоморфина (см. разделы "Взаимодействие с другими лекарственными средствами" и "Особые указания");
- желудочно-кишечные кровотечения, механическая непроходимость или перфорация (т.е. когда стимуляция двигательной функции желудка может быть опаной);
- нарушения функции печени средней и тяжелой степени;
- фенилкетонурия;
- масса тела менее 35 кг;
- детский возраст до 12 лет, при массе тела < 35 кг.

Способ применения и дозы

Внутрь. Рекомендуется принимать таблетки Мотилиум ЭКСПРЕСС за 15 - 30 минут до еды, в случае приема препарата после еды абсорбция домперидона может замедляться.
Взрослые и дети старше 12 лет с массой тела 35 кг и более
По 1 таблетке (10 мг) З раза в сутки, максимальная суточная доза составляет З таблетки (30 мг).
Дети до 12 лет и с массой тела 35 кг и более
По 1 таблетке (10 мг) З раза в сутки, максимальная суточная доза составляет З таблетки (30 мг).
В детской практике в основном следует использовать суспензию МОТИЛИУМ.
Обычно для терапии острой тошноты и рвоты максимальная продолжительность непрерывного приема препарата не должна превышать одну неделю. Если тошнота и рвота продолжаются дольше одной недели, пациенту следует повторно проконсультироваться со своим врачом. По другим показаниям продолжительность терапии составляет 4 недели. Если симптомы не исчезают в течение 4 недель, необходимо провести повторное обследование пациента и оценить необходимость в продолжении терапии.
Применение у пациентов с почечной недостаточностью
Поскольку период полувыведения домперидона при тяжелой почечной недостаточности (при уровне креатинина в сыворотке > 6 мг/100 мл, т. е., > 0,6 ммоль/л) увеличивается, частоту приема Мотилиум ЭКСПРЕСС, таблетки, для рассасывания, следует снизить до 1 или 2 раз в сутки, в зависимости от тяжести недостаточности. Необходимо проводить регулярное обследование пациентов с тяжелой почечной недостаточностью (см. раздел "Фармакологические свойства").
Применение пациентов с печеночной недостаточностью
Применение МОТИЛИУМ ЭКСПРЕСС противопоказано у пациентов со среднетяжелой (7 - 9 по классификации Чайлд-Пью) или тяжелой (> 9 по классификации Чайлд-Пью) печеночной недостаточностью (см. раздел «Противопоказания»). У пациентов с легкой (5 - 6 по классификации Чайлд-Пью) печеночной недостаточностью коррекции дозы препарата не требуется (см. раздел
«Фармакологические свойства»).
Поскольку таблетки для рассасывания довольно хрупки, во избежание повреждения их не следует продавливать сквозь фольгу. Для того чтобы достать таблетку из блистера необходимо следующее:
- возьмите фольгу за край и полностью снимите ее с ячейки, в которой находится таблетка;
- осторожно надавите снизу;
- извлеките таблетку из упаковки.
Положите таблетку на язык. В течение нескольких секунд она распадется на поверхности языка, ее можно будет проглотить со слюной, не запивая водой.
Полная инструкция
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Мотилиум экспресс таб. д/рассас.
Мотилиум экспресс таб. д/рассас., 10 мг, 10 шт.
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5.0
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    Таблетница из 14 секций на семь дней Утро-вечер

    Цена 177 ₽ вместо 220
  • Регидрон Био пор. д/приг. р-ра д/вн. приема саше, 6.4 г, 5 шт.
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    Регидрон Био пор. д/приг. р-ра д/вн. приема саше, 6.4 г, 5 шт.

    Цена 644 ₽ вместо 658
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 773 ₽ вместо 1 890
  • Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

    Цена 209 ₽ вместо 599
  • Фитомуцил норм пор. саше, 5 г, 10 шт., нейтральный, 1 уп.
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    Фитомуцил норм пор. саше, 5 г, 10 шт., нейтральный, 1 уп.

    Цена 464 ₽ вместо 469
  • Таблетница на день мини для капсул контейнер для таблеток белый
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    Таблетница на день мини для капсул контейнер для таблеток белый

    Цена 282 ₽ вместо 750
  • Таблетница, 3 секции, цвет микс
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    Таблетница, 3 секции, цвет микс

    Цена 157 ₽ вместо 227
  • Таблетница на день / органайзер для лекарств контейнер
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    Таблетница на день / органайзер для лекарств контейнер

    Цена 411 ₽ вместо 999
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    Реклама
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  • Бак-сет форте капс., 10 шт., нейтральный, 1 уп.
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    Бак-сет форте капс., 10 шт., нейтральный, 1 уп.

    Цена 455 ₽ вместо 460
  • Фитолакс таб. жев., 20 шт., абрикос, 1 уп.
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    Фитолакс таб. жев., 20 шт., абрикос, 1 уп.

    Цена 350 ₽ вместо 358
  • Гепатрин капс., 120 шт.
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    Гепатрин капс., 120 шт.

    Цена 886 ₽ вместо 1 000
  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)
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    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)

    Цена 245 ₽ вместо 263
  • Таблетница, органайзер на день, неделю, контейнер для таблеток, лекарств и витамин
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    Таблетница, органайзер на день, неделю, контейнер для таблеток, лекарств и витамин

    Цена 149 ₽ вместо 470
  • Таблетница на день 3 ячейки Oxitab синяя
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    Таблетница на день 3 ячейки Oxitab синяя

    Цена 241 ₽ вместо 520
  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 168 ₽ вместо 400
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 460 ₽ вместо 637
  • California Gold Nutrition LactoBif капс., 5 млрд КОЕ, 30 г, 10 шт., нейтральный, 1 уп.
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    California Gold Nutrition LactoBif капс., 5 млрд КОЕ, 30 г, 10 шт., нейтральный, 1 уп.

    Цена 1 456 ₽ вместо 2 200
  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
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    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Цена 706 ₽ вместо 1 039
  • Таблетница, 9,7 × 2,7 × 1,7 см, 4 секции, цвет микс
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    Таблетница, 9,7 × 2,7 × 1,7 см, 4 секции, цвет микс

    Цена 269 ₽ вместо 330
  • Таблетница, 9,5 × 5 × 2 см, 3 секции, цвет микс (арт. 3734585)
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    Таблетница, 9,5 × 5 × 2 см, 3 секции, цвет микс (арт. 3734585)

    Цена 287 ₽ вместо 352
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    Реклама
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  • Таблетница «Неделька», английские буквы, 7 секций, цвет прозрачный
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    Таблетница «Неделька», английские буквы, 7 секций, цвет прозрачный

    Цена 351 ₽ вместо 449
  • Таблетница, 3 секции, цвет микс
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    Таблетница, 3 секции, цвет микс

    Цена 327 ₽ вместо 666
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