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Описание

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Мотилиум таб. п/о плен., 10 мг, 30 шт.

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У продавца: 
нет • На Маркете: 4.9
(19)
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Коротко о товаре

Артикул Маркета
2227830316
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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Рекомендуется принимать таблетки Мотилиум за 15-30 минут до еды, в случае приема препарата после еды абсорбция домперидона может замедляться.\u003Cbr\u003EВзрослые и дети старше 12 лет с массой тела 35 кг и более\u003Cbr\u003EПо 1 таблетке (10 мг) 3 раза в сутки, максимальная суточная доза составляет 3 таблетки (30 мг).\u003Cbr\u003EМаксимальная продолжительность применения препарата не должна превышать 7 дней и определяется назначением лечащего врача.\u003Cbr\u003EПрименение у пациентов с почечной недостаточностью\u003Cbr\u003EПоскольку период полувыведения домперидона при тяжелой почечной недостаточности (при уровне креатинина в сыворотке \u003E 6 мг/100 мл, т. е., \u003E0,6 ммоль/л) увеличивается, частоту приема препарата, следует снизить до 1 или 2 раз в сутки, в зависимости от тяжести недостаточности. 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Очень редко: анафилактические реакции, включая анафилактический шок. \u003Cbr\u003E\nПсихические нарушения. Очень редко: повышенная возбудимость, нервозность, раздражительность. \u003Cbr\u003E\nНарушения со стороны нервной системы. Очень редко: сонливость, головная боль, головокружение, экстрапирамидные расстройства и судороги. \u003Cbr\u003E\nНарушения со стороны сердечно-сосудистой системы. Частота неизвестна: желудочковая аритмия*, желудочковая тахикардия по типу «пируэт», внезапная коронарная смерть*. \u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей. Очень редко: крапивница, ангионевротический отек. \u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей. Очень редко: задержка мочи. \u003Cbr\u003E\nЛабораторные и инструментальные данные. Очень редко: отклонения лабораторных показателей функции печени, гиперпролактинемия. \u003Cbr\u003E\n*В некоторых эпидемиологических исследованиях было показано, что применение домперидона может быть связано с повышением риска развития серьезных желудочковых аритмий или внезапной смерти. Риск возникновения данных явлений более вероятен у пациентов старше 60 лет и у пациентов, принимающих препарат в суточной дозе более 30 мг. Рекомендовано применение домперидона в наименьшей эффективной дозе у взрослых и детей. \u003Cbr\u003E\nНежелательные реакции, выявленные в ходе пострегистрационных клинических исследований \u003Cbr\u003E\nНарушения со стороны иммунной системы. Частота неизвестна: анафилактические реакции, включая анафилактический шок. \u003Cbr\u003E\nПсихические нарушения. Нечасто: повышенная возбудимость, нервозность.\nНарушения со стороны нервной системы. Часто: головокружение. Редко: судороги. Частота неизвестна: экстрапирамидные расстройства. \u003Cbr\u003E\nНарушения со стороны сердечно-сосудистой системы. Частота неизвестна: желудочковая аритмия*, желудочковая тахикардия по типу «пируэт», внезапная коронарная смерть*. \u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта. Частота неизвестна: сухость во рту. \u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей. Частота неизвестна: ангионевротический отек. \u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей. Нечасто: задержка мочи. \u003Cbr\u003E\nЛабораторные и инструментальные данные. Нечасто: отклонения лабораторных показателей функции печени. Редко: гиперпролактинемия. \u003Cbr\u003E\n*В некоторых эпидемиологических исследованиях было показано, что применение домперидона может быть связано с повышением риска развития серьезных желудочковых аритмий или внезапной смерти. Риск возникновения данных явлений более вероятен у пациентов старше 60 лет и у пациентов, принимающих препарат в суточной дозе более 30 мг. Рекомендовано применение домперидона в наименьшей эффективной дозе у взрослых и детей."},{"name":"Фармакологическое действие","value":"Домперидон – антагонист дофамина, обладающий противорвотными свойствами. Домперидон плохо проникает через гематоэнцефалический барьер. Применение домперидона редко сопровождается экстрапирамидными побочными действиями, особенно у взрослых, но домперидон стимулирует выделение пролактина из гипофиза. Его противорвотное действие может быть обусловлено сочетанием периферического (гастрокинетического) действия и антагонизма к рецепторам дофамина в хеморецепторной триггерной зоне, которая находится за пределами гематоэнцефалического барьера. Исследования на животных и низкие концентрации препарата, выявляемые в головном мозге, свидетельствуют о преимущественно периферическом действии домперидона на дофаминовые рецепторы. \u003Cbr\u003E\nПри применении внутрь домперидон увеличивает продолжительность антральных и дуоденальных сокращений, ускоряет опорожнение желудка и повышает давление сфинктера нижнего отдела пищевода. Домперидон не оказывает действия на желудочную секрецию."},{"name":"Фармакологическая группа","value":"противорвотное средство - дофаминовых рецепторов блокатор центральный"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"Хранить при температуре от 15 до 30° С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"\tСимптомы передозировки встречаются чаще всего у младенцев и детей. Признаками передозировки служат ажитация, измененное сознание, судороги, дезориентация, сонливость и экстрапирамидные реакции. \u003Cbr\u003E\nЛечение передозировки: Симптоматическое, специфического антидота нет. Промывание желудка, прием активированного угля, при возникновении экстрапирамидных реакций – антихолинергические, противопаркинсонические средства. Из-за возможного увеличения интервала QT следует мониторировать электрокардиограмму (ЭКГ)."},{"name":"Применение при беременности и кормлении грудью","value":"Мотилиум противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Необходимо соблюдать осторожность при управлении транспортными средствами и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций в связи с риском развития побочных реакций, которые могут влиять на указанные способности."},{"name":"Особые указания","value":"Домперидон не рекомендуется применять для профилактики тошноты и рвоты после наркоза. При длительной терапии препаратом пациенты должны находиться под регулярным наблюдением врача. \u003Cbr\u003E\nДомперидон может вызывать удлинение интервала QT на ЭКГ. В ходе постмаркетинговых исследований у пациентов, принимающих домперидон, в редких случаях отмечалось увеличение интервала QT и возникновение желудочковой тахикардии по типу «пируэт». Данные нежелательные реакции были отмечены, в основном, у пациентов с факторами риска, с выраженными электролитными нарушениями или одновременно принимающих препараты, увеличивающие интервал QT. \u003Cbr\u003E\nВ ходе некоторых исследований было показано, что применение домперидона может привести к увеличению риска желудочковой аритмии или внезапной коронарной смерти (в особенности у пациентов старше 60 лет или при применении разовой дозы более 30 мг, а также у пациентов, одновременно принимающих препараты, увеличивающие интервал QT, или ингибиторы CYP3A4). Домперидон противопоказан при совместном приеме с лекарственными средствами, удлиняющими интервал QT, за исключением апоморфина. Применение совместно с апоморфином возможно только в том случае, если преимущество совместного применения домперидона с апоморфином превышает риски и только если строго соблюдаются рекомендуемые меры предосторожности для совместного применения препаратов, упомянутые в инструкции по медицинскому применению апоморфина. \u003Cbr\u003E\nПрименение домперидона и других препаратов, способных вызвать удлинение интервала QT, не рекомендовано у пациентов с выраженными электролитными нарушениями (гипо- и гиперкалиемия, гипомагнезиемия) или у пациентов с заболеваниями сердца, такими как хроническая сердечная недостаточность. Было показано, что наличие у пациента электролитных нарушений (гипо- и гиперкалиемия, гипомагнезиемия) и брадикардии может увеличить риск развития аритмии. Прием домперидона следует прекратить при возникновении любых симптомов, которые могут быть ассоциированы с нарушением ритма сердца. В этом случае необходимо проконсультироваться с врачом. \u003Cbr\u003E\nПри одновременном применении домперидон усиливает действие нейролептиков. При одновременном применении препарата с агонистами дофаминергических рецепторов (бромокриптин, леводопа) домперидон угнетает нежелательные периферические эффекты последних (такие как нарушение пищеварения, тошнота и рвота), не влияя при этом на их центральные эффекты. Препарат рекомендуется принимать в минимальной эффективной дозе. \u003Cbr\u003E\nЕсли лекарственное средство пришло в негодность или истек срок годности, не выбрасывайте его в сточные воды и на улицу. Поместите лекарственное средство в пакет и положите в мусорный контейнер. Эти меры помогут защитить окружающую среду!"},{"name":"Взаимодействие","value":"Взаимодействие со следующими препаратами может повышать риск увеличения интервала QT. Противопоказанные комбинации – препараты, увеличивающие интервал QT: антиаритмические препараты класса IA (например, дизопирамид, гидрохинидин, хинидин), антиаритмические препараты класса III (например, амиодарон, дофетидил, дронедарон, ибутилид, соталол), антипсихотические средства (например, галоперидол, пимозид, сертиндол), антидепрессанты (например, циталопрам, эсциталопрам), антибиотики (эритромицин, левофлоксацин, моксифлоксацин, спирамицин), противогрибковые препараты (например, пентамидин), антималярийные препараты (в частности, галофантрин, лумефантрин), желудочно-кишечные препараты (например, цизаприд, доласетрон, прукалоприд), антигистаминные препараты (например, мехитазин, мизоластин), противоопухолевые препараты (например, торемифен, вандетаниб, винкамин), другие препараты (например, бепридил, дифеманила метилсульфат, метадон), мощные ингибиторы CYP3A4 (ингибиторы протеазы, противогрибковые средства азолового ряда, некоторые антибиотики из группы макролидов (эритромицин, кларитромицин, телитромицин). Нерекомендованные комбинации: умеренные ингибиторы CYP3A4 (дилтиазем, верапамил, некоторые антибиотики из группы макролидов). Комбинации, которые следует применять с осторожностью: препараты, вызывающие брадикардию и гипокалиемию, а также азитромицин и рокситромицин. Циметидин, натрия гидрокарбонат, другие антацидные и антисекреторные препараты снижают биодоступность домперидона. Повышают концентрацию домперидона в плазме крови: противогрибковые средства азолового ряда, антибиотики из группы макролидов, ингибиторы ВИЧ-протеазы, нефазодон. Домперидон совместим с приемом антипсихотических лекарственных средств (нейролептиков), агонистами дофаминергических рецепторов (бромокриптин, леводопа). Одновременное применение с парацетамолом и дигоксином не оказывает влияния на концентрацию этих лекарственных средств в крови. Применение совместно с апоморфином возможно только в том случае, если преимущество совместного применения превышает риски и только если строго соблюдаются рекомендуемые меры предосторожности для совместного применения препаратов."},{"name":"Регистрационный номер","value":"П N014853/01"},{"name":"Дата государственной регистрации","value":"01.04.2021"},{"name":"Владелец регистрационного удостоверения","value":"Johnson & Johnson","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:10789460"]}}},{"name":"Изготовитель","value":"Janssen-Cilag S.p.A."},{"name":"Фасовщик","value":"Janssen-Cilag S.p.A."},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Мотилиум","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18008590"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"12619006346108874334":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"пищеварительная система"},{"name":"Назначение","value":"диспепсические явления, рвота, тошнота"},{"name":"Показания к применению","value":"Для облегчения симптомов тошноты и рвоты."},{"name":"Противопоказания","value":"- повышенная чувствительность к домперидону или любому другому компоненту препарата;\u003Cbr\u003E- непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция;\u003Cbr\u003E- пролактинома;\u003Cbr\u003E- одновременное применение пероральных форм кетоконазола, эритромицина или других мощных ингибиторов изофермента CYP3A4, вызывающих удлинение интервала QT (таких как кларитромицин, итраконазол, флуконазол, позаконазол, ритонавир, саквинавир, амиодарон, телитромицин, телапревир и вориконазол), за исключением апоморфина (см.разделы \"Взаимодействие с другими лекарственным и средствами\" и \"Особые указания\");\u003Cbr\u003E- выраженные электролитные нарушения или заболевания сердца, такие как хроническая сердечная недостаточность;\u003Cbr\u003E- кровотечения из желудочно-кишечного тракта, механическая кишечная непроходимость, перфорация желудка или кишечника;\u003Cbr\u003E- печеночная недостаточность средней и тяжелой степени тяжести;\u003Cbr\u003E- масса тела менее 35 кг;\u003Cbr\u003E- детский возраст до 12 лет с массой тела менее 35 кг;\u003Cbr\u003E- беременность;\u003Cbr\u003E- период грудного вскармливания."},{"name":"Состав","value":"действующее вещество: домперидон 10 мг;\u003Cbr\u003E\nвспомогательные вещества: лактозы моногидрат 54,2 мг, кукурузный крахмал 20 мг, целлюлоза микрокристаллическая 10 мг, прежелатинизированный крахмал 3 мг, повидон К90 1,5 мг, магния стеарат 0,6 мг, хлопка семян масло гидрогенизированное 0,5 мг, натрия лаурилсульфат 0,15 мг.\u003Cbr\u003E\nПленочная оболочка: гипромеллоза 2910 5 мПахс 2,2 мг, натрия лаурилсульфат 0,05 мг.\n"},{"name":"Действующее вещество","value":"Домперидон"},{"name":"Способ применения и дозы","value":"Внутрь. Рекомендуется принимать таблетки Мотилиум за 15-30 минут до еды, в случае приема препарата после еды абсорбция домперидона может замедляться.\u003Cbr\u003EВзрослые и дети старше 12 лет с массой тела 35 кг и более\u003Cbr\u003EПо 1 таблетке (10 мг) 3 раза в сутки, максимальная суточная доза составляет 3 таблетки (30 мг).\u003Cbr\u003EМаксимальная продолжительность применения препарата не должна превышать 7 дней и определяется назначением лечащего врача.\u003Cbr\u003EПрименение у пациентов с почечной недостаточностью\u003Cbr\u003EПоскольку период полувыведения домперидона при тяжелой почечной недостаточности (при уровне креатинина в сыворотке \u003E 6 мг/100 мл, т. е., \u003E0,6 ммоль/л) увеличивается, частоту приема препарата, следует снизить до 1 или 2 раз в сутки, в зависимости от тяжести недостаточности. Необходимо проводить регулярное обследование пациентов с тяжелой почечной недостаточностью (см. раздел \"Фармакологические свойства\").\u003Cbr\u003EПрименение у пациентов с печеночной недостаточностью\u003Cbr\u003EПрименение препарата противопоказано у пациентов с печеночной недостаточностью средней и тяжелой степени тяжести (см. раздел \"Противопоказания\"). У пациентов с легкой печеночной недостаточностью коррекции дозы препарата не требуется (см. раздел \"Фармакологические свойства\")."},{"name":"Побочные действия","value":"По данным клинических исследований \u003Cbr\u003E\nНежелательные реакции, наблюдавшиеся у ≥ 1% пациентов, принимавших МОТИЛИУМ: депрессия, тревога, снижение или отсутствие либидо, головная боль, сонливость, акатизия, диарея, сыпь, зуд, увеличение молочных желез/гинекомастия, боль и чувствительность в области молочных желез, галакторея, нарушения менструального цикла и аменорея, нарушение лактации, астения. \u003Cbr\u003E\nНежелательные реакции, наблюдавшиеся у \u003C 1% пациентов, принимавших МОТИЛИУМ: гиперчувствительность, крапивница, отек молочных желез, выделения из молочных желез. \u003Cbr\u003E\nПриведенные ниже нежелательные эффекты классифицировали следующим образом: очень часто (≥ 10 %), часто (≥ 1 %, но \u003C 10 %), нечасто (≥ 0,1 %, но \u003C 1 %), редко \n(≥ 0,01 %, но \u003C 0,1 %) и очень редко (\u003C 0,01 %), включая отдельные случаи. \u003Cbr\u003E\nПо данным спонтанных сообщений о нежелательных явлениях \u003Cbr\u003E\nНарушения со стороны иммунной системы. Очень редко: анафилактические реакции, включая анафилактический шок. \u003Cbr\u003E\nПсихические нарушения. Очень редко: повышенная возбудимость, нервозность, раздражительность. \u003Cbr\u003E\nНарушения со стороны нервной системы. Очень редко: сонливость, головная боль, головокружение, экстрапирамидные расстройства и судороги. \u003Cbr\u003E\nНарушения со стороны сердечно-сосудистой системы. Частота неизвестна: желудочковая аритмия*, желудочковая тахикардия по типу «пируэт», внезапная коронарная смерть*. \u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей. Очень редко: крапивница, ангионевротический отек. \u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей. Очень редко: задержка мочи. \u003Cbr\u003E\nЛабораторные и инструментальные данные. Очень редко: отклонения лабораторных показателей функции печени, гиперпролактинемия. \u003Cbr\u003E\n*В некоторых эпидемиологических исследованиях было показано, что применение домперидона может быть связано с повышением риска развития серьезных желудочковых аритмий или внезапной смерти. Риск возникновения данных явлений более вероятен у пациентов старше 60 лет и у пациентов, принимающих препарат в суточной дозе более 30 мг. Рекомендовано применение домперидона в наименьшей эффективной дозе у взрослых и детей. \u003Cbr\u003E\nНежелательные реакции, выявленные в ходе пострегистрационных клинических исследований \u003Cbr\u003E\nНарушения со стороны иммунной системы. Частота неизвестна: анафилактические реакции, включая анафилактический шок. \u003Cbr\u003E\nПсихические нарушения. Нечасто: повышенная возбудимость, нервозность.\nНарушения со стороны нервной системы. Часто: головокружение. Редко: судороги. Частота неизвестна: экстрапирамидные расстройства. \u003Cbr\u003E\nНарушения со стороны сердечно-сосудистой системы. Частота неизвестна: желудочковая аритмия*, желудочковая тахикардия по типу «пируэт», внезапная коронарная смерть*. \u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта. Частота неизвестна: сухость во рту. \u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей. Частота неизвестна: ангионевротический отек. \u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей. Нечасто: задержка мочи. \u003Cbr\u003E\nЛабораторные и инструментальные данные. Нечасто: отклонения лабораторных показателей функции печени. Редко: гиперпролактинемия. \u003Cbr\u003E\n*В некоторых эпидемиологических исследованиях было показано, что применение домперидона может быть связано с повышением риска развития серьезных желудочковых аритмий или внезапной смерти. Риск возникновения данных явлений более вероятен у пациентов старше 60 лет и у пациентов, принимающих препарат в суточной дозе более 30 мг. Рекомендовано применение домперидона в наименьшей эффективной дозе у взрослых и детей."},{"name":"Фармакологическое действие","value":"Домперидон – антагонист дофамина, обладающий противорвотными свойствами. Домперидон плохо проникает через гематоэнцефалический барьер. Применение домперидона редко сопровождается экстрапирамидными побочными действиями, особенно у взрослых, но домперидон стимулирует выделение пролактина из гипофиза. Его противорвотное действие может быть обусловлено сочетанием периферического (гастрокинетического) действия и антагонизма к рецепторам дофамина в хеморецепторной триггерной зоне, которая находится за пределами гематоэнцефалического барьера. Исследования на животных и низкие концентрации препарата, выявляемые в головном мозге, свидетельствуют о преимущественно периферическом действии домперидона на дофаминовые рецепторы. \u003Cbr\u003E\nПри применении внутрь домперидон увеличивает продолжительность антральных и дуоденальных сокращений, ускоряет опорожнение желудка и повышает давление сфинктера нижнего отдела пищевода. Домперидон не оказывает действия на желудочную секрецию."},{"name":"Фармакологическая группа","value":"противорвотное средство - дофаминовых рецепторов блокатор центральный"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре от 15 до 30° С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"\tСимптомы передозировки встречаются чаще всего у младенцев и детей. Признаками передозировки служат ажитация, измененное сознание, судороги, дезориентация, сонливость и экстрапирамидные реакции. \u003Cbr\u003E\nЛечение передозировки: Симптоматическое, специфического антидота нет. Промывание желудка, прием активированного угля, при возникновении экстрапирамидных реакций – антихолинергические, противопаркинсонические средства. Из-за возможного увеличения интервала QT следует мониторировать электрокардиограмму (ЭКГ)."},{"name":"Применение при беременности и кормлении грудью","value":"Мотилиум противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Необходимо соблюдать осторожность при управлении транспортными средствами и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций в связи с риском развития побочных реакций, которые могут влиять на указанные способности."},{"name":"Особые указания","value":"Домперидон не рекомендуется применять для профилактики тошноты и рвоты после наркоза. При длительной терапии препаратом пациенты должны находиться под регулярным наблюдением врача. \u003Cbr\u003E\nДомперидон может вызывать удлинение интервала QT на ЭКГ. В ходе постмаркетинговых исследований у пациентов, принимающих домперидон, в редких случаях отмечалось увеличение интервала QT и возникновение желудочковой тахикардии по типу «пируэт». Данные нежелательные реакции были отмечены, в основном, у пациентов с факторами риска, с выраженными электролитными нарушениями или одновременно принимающих препараты, увеличивающие интервал QT. \u003Cbr\u003E\nВ ходе некоторых исследований было показано, что применение домперидона может привести к увеличению риска желудочковой аритмии или внезапной коронарной смерти (в особенности у пациентов старше 60 лет или при применении разовой дозы более 30 мг, а также у пациентов, одновременно принимающих препараты, увеличивающие интервал QT, или ингибиторы CYP3A4). Домперидон противопоказан при совместном приеме с лекарственными средствами, удлиняющими интервал QT, за исключением апоморфина. Применение совместно с апоморфином возможно только в том случае, если преимущество совместного применения домперидона с апоморфином превышает риски и только если строго соблюдаются рекомендуемые меры предосторожности для совместного применения препаратов, упомянутые в инструкции по медицинскому применению апоморфина. \u003Cbr\u003E\nПрименение домперидона и других препаратов, способных вызвать удлинение интервала QT, не рекомендовано у пациентов с выраженными электролитными нарушениями (гипо- и гиперкалиемия, гипомагнезиемия) или у пациентов с заболеваниями сердца, такими как хроническая сердечная недостаточность. Было показано, что наличие у пациента электролитных нарушений (гипо- и гиперкалиемия, гипомагнезиемия) и брадикардии может увеличить риск развития аритмии. Прием домперидона следует прекратить при возникновении любых симптомов, которые могут быть ассоциированы с нарушением ритма сердца. В этом случае необходимо проконсультироваться с врачом. \u003Cbr\u003E\nПри одновременном применении домперидон усиливает действие нейролептиков. При одновременном применении препарата с агонистами дофаминергических рецепторов (бромокриптин, леводопа) домперидон угнетает нежелательные периферические эффекты последних (такие как нарушение пищеварения, тошнота и рвота), не влияя при этом на их центральные эффекты. Препарат рекомендуется принимать в минимальной эффективной дозе. \u003Cbr\u003E\nЕсли лекарственное средство пришло в негодность или истек срок годности, не выбрасывайте его в сточные воды и на улицу. Поместите лекарственное средство в пакет и положите в мусорный контейнер. Эти меры помогут защитить окружающую среду!"},{"name":"Взаимодействие","value":"Взаимодействие со следующими препаратами может повышать риск увеличения интервала QT. Противопоказанные комбинации – препараты, увеличивающие интервал QT: антиаритмические препараты класса IA (например, дизопирамид, гидрохинидин, хинидин), антиаритмические препараты класса III (например, амиодарон, дофетидил, дронедарон, ибутилид, соталол), антипсихотические средства (например, галоперидол, пимозид, сертиндол), антидепрессанты (например, циталопрам, эсциталопрам), антибиотики (эритромицин, левофлоксацин, моксифлоксацин, спирамицин), противогрибковые препараты (например, пентамидин), антималярийные препараты (в частности, галофантрин, лумефантрин), желудочно-кишечные препараты (например, цизаприд, доласетрон, прукалоприд), антигистаминные препараты (например, мехитазин, мизоластин), противоопухолевые препараты (например, торемифен, вандетаниб, винкамин), другие препараты (например, бепридил, дифеманила метилсульфат, метадон), мощные ингибиторы CYP3A4 (ингибиторы протеазы, противогрибковые средства азолового ряда, некоторые антибиотики из группы макролидов (эритромицин, кларитромицин, телитромицин). Нерекомендованные комбинации: умеренные ингибиторы CYP3A4 (дилтиазем, верапамил, некоторые антибиотики из группы макролидов). Комбинации, которые следует применять с осторожностью: препараты, вызывающие брадикардию и гипокалиемию, а также азитромицин и рокситромицин. Циметидин, натрия гидрокарбонат, другие антацидные и антисекреторные препараты снижают биодоступность домперидона. Повышают концентрацию домперидона в плазме крови: противогрибковые средства азолового ряда, антибиотики из группы макролидов, ингибиторы ВИЧ-протеазы, нефазодон. Домперидон совместим с приемом антипсихотических лекарственных средств (нейролептиков), агонистами дофаминергических рецепторов (бромокриптин, леводопа). Одновременное применение с парацетамолом и дигоксином не оказывает влияния на концентрацию этих лекарственных средств в крови. Применение совместно с апоморфином возможно только в том случае, если преимущество совместного применения превышает риски и только если строго соблюдаются рекомендуемые меры предосторожности для совместного применения препаратов."},{"name":"Регистрационный номер","value":"П N014853/01"},{"name":"Дата государственной регистрации","value":"01.04.2021"},{"name":"Владелец регистрационного удостоверения","value":"Johnson & Johnson"},{"name":"Изготовитель","value":"Janssen-Cilag S.p.A."},{"name":"Фасовщик","value":"Janssen-Cilag S.p.A."},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Мотилиум"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_10910524228245679841"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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  • Гепатрин капс., 120 шт.
    –11 %
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    Гепатрин капс., 120 шт.

    Рейтинг товара: 4.8 из 5
    на основе 889 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 886 ₽ вместо 895
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  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
    ВАМ–32 %
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    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Рейтинг товара: 4.5 из 5
    на основе 1315 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 706 ₽ вместо 713
    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  • ЛактоБаланс капс., 7 шт.
    ВАМ–17 %
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    ЛактоБаланс капс., 7 шт.

    Рейтинг товара: 4.8 из 5
    на основе 266 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 562 ₽ вместо 574
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  • Турбослим день капс. усиленная формула, 30 шт.
    –2 %
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    Турбослим день капс. усиленная формула, 30 шт.

    Рейтинг товара: 3 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 065 ₽ вместо 1 087
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  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
    –46 %
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 596 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 881 ₽ вместо 1 900
    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  • California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.
    –30 %
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    California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 733 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 103 ₽ вместо 1 114
    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Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 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  • Лактосорбин таб.
    –1 %
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    Лактосорбин таб.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 316 ₽ вместо 319
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  • Норлакс таб. жев., 0.5 г, 40 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-lckrebhd0v9/toggleWishlist":{"skuId":"101430671112","productId":1424747478,"offerId":"2MLv5cOajdv8XIkrx3w-Sg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ77Pwr77w9rtoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI1tevpwUQiO707fkCGL+R9wcg2tnBBw==","sign":"N+eHwGnvzmDwML/8BfzMrb0SluT7608mBIniI+8xJcI="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-lckrebhd0v9/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Норлакс таб. жев., 0.5 г, 40 шт.

    Рейтинг товара: 4.8 из 5
    на основе 5 оценок
    Цена 397 ₽
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  • Эркасил Силимарин таб., 35 мг, 100 г, 80 шт., 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0lajnsjlob7/toggleWishlist":{"skuId":"101775299468","productId":1756849884,"offerId":"fIJvnSkxCxzYuo7L_JquSg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ77Pwr77w9rtoEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI3M3dxQYQjKefkvsCGPSP9wcg2tnBBw==","sign":"LbV85RTzy7DoCfQF+cYAkFTUTg0gO6p9DAcN2kLBz54="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-0lajnsjlob7/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эркасил Силимарин таб., 35 мг, 100 г, 80 шт., 1 уп.

    Цена 454 ₽
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Инструкция

Показания к применению

Для облегчения симптомов тошноты и рвоты.

Противопоказания

- повышенная чувствительность к домперидону или любому другому компоненту препарата;
- непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция;
- пролактинома;
- одновременное применение пероральных форм кетоконазола, эритромицина или других мощных ингибиторов изофермента CYP3A4, вызывающих удлинение интервала QT (таких как кларитромицин, итраконазол, флуконазол, позаконазол, ритонавир, саквинавир, амиодарон, телитромицин, телапревир и вориконазол), за исключением апоморфина (см.разделы "Взаимодействие с другими лекарственным и средствами" и "Особые указания");
- выраженные электролитные нарушения или заболевания сердца, такие как хроническая сердечная недостаточность;
- кровотечения из желудочно-кишечного тракта, механическая кишечная непроходимость, перфорация желудка или кишечника;
- печеночная недостаточность средней и тяжелой степени тяжести;
- масса тела менее 35 кг;
- детский возраст до 12 лет с массой тела менее 35 кг;
- беременность;
- период грудного вскармливания.

Способ применения и дозы

Внутрь. Рекомендуется принимать таблетки Мотилиум за 15-30 минут до еды, в случае приема препарата после еды абсорбция домперидона может замедляться.
Взрослые и дети старше 12 лет с массой тела 35 кг и более
По 1 таблетке (10 мг) 3 раза в сутки, максимальная суточная доза составляет 3 таблетки (30 мг).
Максимальная продолжительность применения препарата не должна превышать 7 дней и определяется назначением лечащего врача.
Применение у пациентов с почечной недостаточностью
Поскольку период полувыведения домперидона при тяжелой почечной недостаточности (при уровне креатинина в сыворотке > 6 мг/100 мл, т. е., >0,6 ммоль/л) увеличивается, частоту приема препарата, следует снизить до 1 или 2 раз в сутки, в зависимости от тяжести недостаточности. Необходимо проводить регулярное обследование пациентов с тяжелой почечной недостаточностью (см. раздел "Фармакологические свойства").
Применение у пациентов с печеночной недостаточностью
Применение препарата противопоказано у пациентов с печеночной недостаточностью средней и тяжелой степени тяжести (см. раздел "Противопоказания"). У пациентов с легкой печеночной недостаточностью коррекции дозы препарата не требуется (см. раздел "Фармакологические свойства").
Полная инструкция
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Мотилиум таб. п/о плен.
Мотилиум таб. п/о плен., 10 мг, 30 шт.
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1 вопрос
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    Цена 1 881 ₽ вместо 3 500
  • Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.
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    Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.

    Цена 569 ₽ вместо 616
  • Тербинафин крем, 1%, 15 г, 1 шт.
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    Тербинафин крем, 1%, 15 г, 1 шт.

    Цена 78 ₽ вместо 79
  • Ревмафлекс капс., 60 шт., нейтральный, 1 уп.
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    Ревмафлекс капс., 60 шт., нейтральный, 1 уп.

    Цена 948 ₽ вместо 958
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    Реклама
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  • Силденафил-СЗ таб. п/о плен., 100 мг, 10 шт.
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    Силденафил-СЗ таб. п/о плен., 100 мг, 10 шт.

    Цена 314 ₽
  • California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.
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    California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.

    Цена 1 103 ₽ вместо 1 581
  • Гепатрин капс., 120 шт.
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    Гепатрин капс., 120 шт.

    Цена 886 ₽ вместо 1 000
  • Лактосорбин таб.
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    Лактосорбин таб.

    Цена 316 ₽ вместо 319
  • Жидкий пластырь Fixplast c пантенолом, 60 мл
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    Жидкий пластырь Fixplast c пантенолом, 60 мл

    Цена 318 ₽ вместо 399
  • ЛимфоТранзит концентрат напитка фл., 100 мл
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_14/content/content/gallery":{"title":"ЛимфоТранзит концентрат напитка фл., 100 мл","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ77Pwr77w9rtoEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMD4ltEGEI2Jl7wCGNW7oQYg19zBBw==","sign":"rwzTCYzzIcQpfqanNMx7324u1h4vSSG20FmAjLiFc4c="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_14/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 361 ₽ вместо 365
  • Норлакс таб. жев., 0.5 г, 40 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1424747478_15/content/content/toggleWishlist":{"skuId":"101430671112","productId":1424747478,"offerId":"2MLv5cOajdv8XIkrx3w-Sg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ77Pwr77w9rtoEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCNbXr6cFEIju9O35Ahi/kfcHINrZwQc=","sign":"syFvDN4dz2YTrxiu98ZjqgPPxYLpTg7Orjh4Ht0IBIg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1424747478_15/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Норлакс таб. жев., 0.5 г, 40 шт.

    Цена 397 ₽
  • Нафтизин капли наз. фл.-кап., 0.1%, 10 мл
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    Нафтизин капли наз. фл.-кап., 0.1%, 10 мл

    Цена 18 ₽
  • Бинт когезивный (самофиксирующийся) "Вариант", 4м х 6см , белый, 2 шт. в наборе
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    Бинт когезивный (самофиксирующийся) "Вариант", 4м х 6см , белый, 2 шт. в наборе

    Цена 354 ₽ вместо 389
  • Йодомарин таб., 0.1 мг, 100 шт.
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    Йодомарин таб., 0.1 мг, 100 шт.

    Цена 136 ₽ вместо 152
  • Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.
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    Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.

    Цена 306 ₽ вместо 520
  • Лимфомиозот капли д/вн. приема, 30 мл
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    Лимфомиозот капли д/вн. приема, 30 мл

    Цена 910 ₽ вместо 1 081
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    Реклама
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  • Турбослим день капс. усиленная формула, 30 шт.
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    Турбослим день капс. усиленная формула, 30 шт.

    Цена 1 006 ₽ вместо 1 016
  • Эркасил Силимарин таб., 35 мг, 100 г, 80 шт., 1 уп.
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    Эркасил Силимарин таб., 35 мг, 100 г, 80 шт., 1 уп.

    Цена 454 ₽
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