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Описание

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Налтрексон капс., 50 мг, 10 шт.

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Коротко о товаре

Артикул Маркета
4546398484
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
{"widgets":{"@card/SpecsList":{"/content/page/fancyPage/productSpecsList":{"wrapperProps":{"margins":{"top":4,"bottom":4}},"specsLimit":5,"title":"Коротко о товаре","titleSize":"14","type":"minimal","offset":"s","isHealthCategory":true,"forceShowWidget":true,"withFridge":true}}},"meta":{"/content/page/fancyPage/productSpecsList":{"name":"@card/SpecsList"}},"collections":{"minimalSpecs":{"5776531839556663086":{"specItems":[{"name":"Артикул Маркета","value":"4546398484","withCopyValueButton":true},{"name":"тип препарата","value":"рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"назначение","value":"алкоголизм, предотвращение рецидива опиоидной зависимости","transition":{"type":"list","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["36476390:36618746,36617860"]}}},{"name":"действующее вещество","value":"Налтрексон","transition":{"type":"list","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["27144131:28710395"]}}},{"name":"возраст","value":"от 18 лет"},{"name":"форма выпуска","value":"капсулы"},{"name":"страна-производитель","value":"Россия"}]}},"compactSpecs":{"5776531839556663086":{"specItems":[{"name":"Артикул Маркета","value":"4546398484","withCopyValueButton":true},{"name":"Тип препарата","value":"Рецептурный лекарственный препарат","transition":{"type":"list","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["27272850:1,0","34324371:35649313"]}}},{"name":"Действующее вещество","value":"Налтрексон","transition":{"type":"list","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["27144131:28710395"]}}},{"name":"Возраст","value":"От 18 лет"},{"name":"Форма выпуска","value":"Капсулы"}]}},"fullSpecs":{"5776531839556663086":{"specItems":[{"name":"Тип препарата","value":"лекарственный препарат","transition":{"type":"catalog","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["34324371:35649313"]}}},{"name":"Рецептурный препарат","value":"да","transition":{"type":"catalog","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["27272850:1,0"]}}},{"name":"Назначение","value":"алкоголизм, предотвращение рецидива опиоидной зависимости","transition":{"type":"catalog","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["36476390:36618746,36617860"]}}},{"name":"Показания к применению","value":"Лечение алкогольной зависимости и блокада эффектов экзогенно введенных опиоидов.\u003Cbr\u003EКомплексная терапия опиоидной зависимости с целью поддержания у пациента состояния, при котором опиоиды не смогут оказать характерного действия.\u003Cbr\u003EЛекарственный препарат показан для предотвращения рецидива опиоидной зависимости после опиодной детоксикации.\u003Cbr\u003EКомплексная терапия алкоголизма, в том числе при поддерживающей терапии, в тех же дозировках, что и при героиновой зависимости на фоне психотерапии."},{"name":"Противопоказания","value":"Пациенты, имеющие зависимость от опиоидов, в том числе находящиеся на лечении опиоидными агонистами или частичными агонистами. Положительная налоксоновая проба. Применение опиоидных анальгетиков или положительный анализ на содержание в моче опиоидов. Положительный тест на наличие опиоидов в моче. Опиоидный абстинентный синдром. Гиперчувствительность к компонентам препарата. Острый гепатит или печеночная недостаточность. Дефицит лактазы, непереносимость лактозы. Глюкозо-галактозная мальабсорбция."},{"name":"Состав","value":"Одна капсула содержит:\u003Cbr\u003EДействующее вещество:\u003Cbr\u003Eналтрексона гидрохлорид в пересчете на 100 % вещество - 50,0 мг.\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003Eлактозы моногидрат - 98,5 мг, магния стеарат - 1,5 мг.\u003Cbr\u003EКапсула твердая желатиновая № 4 - 38,0 мг.\u003Cbr\u003EКорпус капсулы:\u003Cbr\u003Eтитана диоксид (Е 171) - 2 %, желатин до 100 %.\u003Cbr\u003EКрышечка капсулы:\u003Cbr\u003Eкраситель железа оксид желтый (Е 172) - 1,7143 %, титана диоксид (Е 171) -1 %, краситель индигокармин (Е 132) - 0,3 %, желатин до 100 %."},{"name":"Действующее вещество","value":"Налтрексон","transition":{"type":"catalog","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["27144131:28710395"]}}},{"name":"Дозировка","value":"50 мг"},{"name":"Способ применения и дозы","value":"Лечение опиоидной зависимости.\u003Cbr\u003EФаза введения в курс терапии налтрексоном.\u003Cbr\u003EЛечение налтрексоном начинают после того, как пациент в течение 7-10 дней воздерживается от приема опиоидов (при отсутствии проявлений синдрома абстиненции). Воздержание от употребления опиоидов идентифицируют по показателям лабораторных исследований мочи на содержание опиоидов.\u003Cbr\u003EЛечение начинают при отрицательной провокационной пробе с 0,5 мг налоксона.\u003Cbr\u003EОписание налоксоновой пробы: пациенту необходимо ввести 0,2-0,4 мг налоксона внутривенно в течение 5 мин или в виде инъекции подкожно либо внутримышечно. Если нет реакции на введение налоксона в течение 15-30 мин, вводят вторую дозу препарата 0,4 мг внутривенно или 0,4-0,8 мг подкожно и наблюдают за реакцией. Проба считается положительной при выраженном мидриазе, изменении аффекта от благодушно-сонливого до дисфорического, поведенческих расстройствах, появлении признаков опийной абстиненции.\u003Cbr\u003EНалоксоновую пробу не проводят пациентам с симптомами абстиненции и при выявлении опиоидов в моче. Налоксоновую пробу можно повторить через 24 ч.\u003Cbr\u003EЛечение налтрексоном начинают с осторожностью, постепенно повышая дозу. Содержимое капсулы растворяют в 50 мл воды. Вначале назначают 25 мг налтрексона внутрь (содержится в 25 мл исходного раствора). Врачу следует контролировать акт проглатывания раствора препарата.\u003Cbr\u003EПоддерживающая терапия налтрексоном.\u003Cbr\u003EНа следующий день после введения начальной дозы налтрексон начинают назначать по 50 мг каждые 24 ч (применения налтрексона в указанной дозе достаточно для блокирования эффектов опиоидов, вводимых парентерально, например, 25 мг героина, введенного внутривенно).\u003Cbr\u003E100 мг налтрексона назначают каждые 2 дня или 150 мг каждые 3 дня.\u003Cbr\u003EЛечение алкоголизма.\u003Cbr\u003EВ составе комбинированной терапии.\u003Cbr\u003EЕжедневный прием 50 мг налтрексона, минимальный курс - 3 месяца. Лечение должно быть частью соответствующей программы устранения алкогольной зависимости. На протяжении курса лечения необходимо отслеживать приверженность всем компонентам лечения алкоголизма, влияющим на благоприятный исход. Медикаментозное лечение рекомендуется сопровождать курсом психотерапии."},{"name":"Побочные действия","value":"Классификация ВОЗ неблагоприятных побочных реакций по частоте развития: очень часто - \u003E1/10; часто - от 1/100 до 1/10; нечасто - от 1/1000 до 1/100; редко - от 1/10000 до 1/1000; очень редко - \u003C1/10000, включая отдельные сообщения.\u003Cbr\u003EВ терапевтических дозах у пациентов, в организме которых не содержаться опиоиды, налтрексон обычно не вызывает серьезных побочных эффектов.\u003Cbr\u003EСо стороны пищеварительной системы: очень часто - тошнота и/или рвота, боль в животе; часто - абдоминальная боль, снижение или повышение аппетита, анорексия, диарея или запоры, сухость слизистой оболочки полости рта, метеоризм, повышение активности \"печеночных\" ферментов, редко - усугубление симптомов геморроя, эрозивно-язвенные поражения желудочно-кишечного тракта.\u003Cbr\u003EСо стороны нервной системы и органов чувств: очень часто - беспокойство, нервозность, необычная усталость, общая слабость, беспокойный сон, \"кошмарные\" сновидения, головная боль; часто - головокружение, нечеткость зрительного восприятия, спутанность сознания, галлюцинации, угнетение центральной нервной системы, редко - депрессия, бред, звон и ощущение заложенности в ушах, боль и чувство жжения в глазах, светобоязнь, раздражительность, сонливость, дезориентация во времени и пространстве, мигрень, обморок, астения, летаргия, тревога.\u003Cbr\u003EСо стороны дыхательной системы: не часто - кашель, охриплость голоса, заложенность носа (гиперемия сосудов носовой полости), затруднение дыхания, зуд в носу, ринорея, чиханье, бронхообструкция, затруднение дыхания, одышка, носовое кровотечение, сухость в горле, повышенное отделение слизистой мокроты, инфекции верхних дыхательных путей, синусит, ларингит, фарингит (в т.ч. стрептококковый), назофарингит, гайморит.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: не часто - боль в груди, повышение артериального давления, тахикардия, сердцебиение, неспецифические изменения на электрокардиограмме, флебит.\u003Cbr\u003EСо стороны органов зрения: редко - конъюнктивит.\u003Cbr\u003EСо стороны мочеполовой системы: часто - сексуальные расстройства у мужчин (задержка эякуляции, снижение потенции), повышение или снижение либидо, не часто - дискомфорт при мочеиспускании, учащение мочеиспускания, отечный синдром (отек лица, пальцев, стоп, голеней).\u003Cbr\u003EАллергические реакции: часто - кожная сыпь, гиперемия кожи (в т.ч. гиперемия лица), гипертермия, кожный зуд, повышение секреции сальных желез, озноб.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: очень часто - боль в спине, скованность суставов, боль в конечностях, спазм, подергивание или скованность мышц; часто - артралгия, миалгия; артрит.\u003Cbr\u003EСо стороны кожных покровов: папулезная сыпь, потница, угри, алопеция. Прочие: сухость во рту или жажда, боль в горле, увеличение или потеря массы тела, боль в паховой области, увеличение лимфатических узлов, лимфо- цитоз; в одном случае описано развитие идиопатической тромбоцитопениче- ской пурпуры на фоне предварительной сенсибилизации к препарату.\u003Cbr\u003EСиндром \"отмены\" опиоидов: абдоминальная боль, спазмы в эпигастральной области, беспокойство, нервозность, усталость, раздражительность, диарея, тахикардия, гипертермия, ринорея, чиханье, \"гусиная кожа\", потливость, зевота, артралгия, тошнота и /или рвота, тремор, общая слабость.\u003Cbr\u003EЕсли любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу.\u003Cbr\u003EПострегистрационный опыт применения\u003Cbr\u003EПо литературным данным описан единичный случай идиопатической тромбо- цитопенической пурпуры у пациента, который возможно, был сенсибилизирован к налтрексону в ходе предыдущего лечения. Выздоровление произошло после отмены препарата и проведения курса кортикостероидной терапии."},{"name":"Фармакологическое действие","value":"Налтрексон является чистым антагонистом опиоидных рецепторов. Конкурентно связывается с опиоидными рецепторами всех типов и предупреждает или устраняет действие как эндогенных опиоидов, так и экзогенных опиоидных препаратов - опиоидных анальгетиков и их суррогатов. Наибольшее сродство имеет к μ- и k-рецепторам. Снижает эффект опиоидных анальгетиков (анальгетический, противодиарейный, противокашлевой); устраняет побочные эффекты опиоидов (в т.ч. эндогенных), за исключением симптомов, обусловленных гистаминовой реакцией. В сравнении с налоксоном действует более сильно и длительно. Может вызвать миоз (механизм неизвестен). Сочетание с опиоидами в больших дозах приводит к повышению высвобождения гистамина с характерной клинической картиной (гиперемия лица, зуд, сыпь). У пациентов с опиоидной зависимостью вызывает приступ абстиненции.\u003Cbr\u003EНалтрексон не вызывает дисульфирам-подобные реакции, как в результате употребления опиоидов и этанола. При алкоголизме связывается с опиоидными рецепторами и блокирует эффекты эндорфинов. Снижает потребность в алкоголе и предотвращает рецидивы в течение 6 месяцев после 12-недельного курса терапии (успех лечения зависит от согласия пациента). Длительное назначение не вызывает толерантности и зависимости.\u003Cbr\u003EПри одновременном длительном назначении предупреждает развитие физической зависимости к морфину, героину и другим опиоидам. В дозе 50 мг блокирует фармакологические эффекты 25 мг внутривенно введенного героина в течение 24 ч, двойная доза (100 мг) - в течение 48 ч, а 150 мг - в течение 3 суток. Конкурентная блокада опиоидных рецепторов может быть преодолена введением более высокой дозы опиоидного анальгетика."},{"name":"Фармакологическая группа","value":"опиоидных рецепторов антагонист"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 25 °С. Хранить в местах, недоступных для детей."},{"name":"Передозировка","value":"Налтрексон является умеренно безопасным препаратом. Согласно исследованиям, даже большие дозы не вызывают серьезных симптомов. При подозрении на интоксикацию следует назначить симптоматическое лечение.\u003Cbr\u003EНа этапе доклинического исследования при повторном введении налтрексона в дозе 100 мг/кг, превышающей максимальную суточную дозу для человека примерно в 35 раз, не выявлено каких-либо существенных изменений в гематологических и биохимических показателях крови, а также в структуре внутренних органов. Местно-раздражающее действие налтрексон также не оказывает."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат по степени токсичности относится к категории С.\u003Cbr\u003EВ экспериментах на крысах (прием в дозах, в 30 раз превышающих рекомендуемые для людей непосредственно перед беременностью и во время беременности) и на кроликах (прием в дозах, в 60 раз превышающих рекомендуемые для людей) установлено наличие тератогенного эффекта.\u003Cbr\u003EПрименение препарата при беременности возможно только в случае, если потенциальная польза от его применения превышает потенциальный риск для плода.\u003Cbr\u003EПри пероральном приеме налтрексона было отмечено выделение налтрексо- на и 6-бета-налтрексола с грудным молоком. Из-за потенциальной канцерогенности и вероятности возникновения у грудных детей серьезных побочных явлений, следует принять решение о прекращении терапии препаратом во время кормления грудью или прекращении грудного вскармливания во время лечения препаратом, в зависимости от степени важности терапии для матери."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Налтрексон эффективен только в составе комплексной терапии зависимости. Перед применением необходимо исключить субклиническую печеночную недостаточность, во время лечения следует периодически контролировать транзиторное повышение активности трансаминаз.\u003Cbr\u003EНалтрексон оказывает гепатотоксическое действие. Поэтому при длительном применении необходимо контролировать функцию печени.\u003Cbr\u003EНалтрексон назначают только после купирования абстинентного синдрома.\u003Cbr\u003EПрепарат начинают принимать только в специализированных учреждениях под контролем врача. Следует внимательно следить за появлением признаков депрессии или суицидальных мыслей у пациентов с алкогольной и/или опиодной зависимостью, в том числе пациентов, получающих лечение нал- трексоном. Членов семей и ухаживающих за пациентами людей следует предупредить о необходимости внимательно следить за возникновением симптомов депрессии или суицидального поведения и немедленно сообщать о возникновении таких симптомов лечащему врачу. Для обеспечения эффективности лечения необходимо проведение комплексной терапии, включающей психологическую поддержку.\u003Cbr\u003EНалтрексон блокирует действие опиоидов. Блокада может быть преодолена повышением доз опиоидов.\u003Cbr\u003EПациента, который получает лечение налтрексоном, следует предупредить о том, что неконтролируемый прием опиоидов в этот период может привести к тяжелому синдрому абстиненции вплоть до развития комы. Существует риск летального исхода.\u003Cbr\u003EНалтрексон оказывает гепатотоксическое действие. Поэтому при длительном применении необходимо контролировать функцию печени.\u003Cbr\u003EНалтрексон необходимо отменить не менее чем за 48 ч до хирургического вмешательства, при котором потребуется применение опиоидных анальгетиков. В случае необходимости проведения экстренной анальгезии с осторожностью назначают опиоиды в повышенной дозе (для преодоления антагонизма), поскольку угнетение дыхания при этом будет более глубоким и продолжительным. Для предотвращения развития острого абстинентного синдрома пациенты должны как минимум за 7-10 дней прекратить прием опиоидов и лекарственных средств, их содержащих, обязательно определение опиоидов в моче и проведение провокационного теста с налоксоном; при несоблюдении этих требований может проявиться абстинентный синдром.\u003Cbr\u003EСтойкое снижение аппетита и прогрессирующее похудание требуют прекращения терапии.\u003Cbr\u003EНеэффективен при лечении кокаиновой, а также неопиоидной лекарственной зависимости.\u003Cbr\u003EВозможно развитие эозинофильной пневмонии, резистентной к антибиотико- терапии; при развитии прогрессирующей одышки и гипоксии необходимо немедленно обратиться к врачу.\u003Cbr\u003EСледует предупреждать пациентов, что:\u003Cbr\u003E- при обращении за медицинской помощью пациенты обязаны информировать медицинских работников о лечении налтрексоном;\u003Cbr\u003E- в случае появления болей в животе, потемнения мочи, пожелтения склер необходимо прекратить прием и обратиться к врачу;\u003Cbr\u003E- при самостоятельном употреблении героина и других опиоидов в малых дозах эффекта от их применения не будет, а дальнейшее увеличение дозы опио- идных средств приведет к летальному исходу (остановка дыхания).\u003Cbr\u003EС осторожностью:\u003Cbr\u003EНарушения функции печени и/или почек."},{"name":"Взаимодействие","value":"Снижает эффективность лекарственных средств, содержащих опиоиды (про- тивокашлевые лекарственные средства, опиоидные анальгетики, противопростудные препараты). Там, где возможно, должны использоваться альтернативные препараты.\u003Cbr\u003EГепатотоксические лекарственные средства увеличивают (взаимно) риск поражения печени.\u003Cbr\u003EДисульфирам ингибирует микросомальное окисление в печени, вследствие чего может вызвать повышение концентрации препаратов в плазме крови, метаболизирующихся в печени (налтрексон), что увеличивает риск интоксикации.\u003Cbr\u003EВозможна летаргия или повышенная сонливость при сочетании с тиоридазином. Ускоряет появление симптомов синдрома \"отмены\" на фоне опиоидной зависимости, характеризующихся стойкостью и трудностью их устранения."},{"name":"Регистрационный номер","value":"ЛП-002591"},{"name":"Дата государственной регистрации","value":"22.11.2021"},{"name":"Владелец регистрационного удостоверения","value":"Московский эндокринный завод","transition":{"type":"catalog","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["34324371:35649313","7893318:16002634"]}}},{"name":"Изготовитель","value":"Московский эндокринный завод"},{"name":"Фасовщик","value":"Московский эндокринный завод"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Налтрексон","transition":{"type":"catalog","params":{"categorySlug":"borba-s-vrednymi-privychkami","categoryId":"15756581","navnodeId":"72484","glfilters":["17796364:17893193"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"5776531839556663086":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Назначение","value":"алкоголизм, предотвращение рецидива опиоидной зависимости"},{"name":"Показания к применению","value":"Лечение алкогольной зависимости и блокада эффектов экзогенно введенных опиоидов.\u003Cbr\u003EКомплексная терапия опиоидной зависимости с целью поддержания у пациента состояния, при котором опиоиды не смогут оказать характерного действия.\u003Cbr\u003EЛекарственный препарат показан для предотвращения рецидива опиоидной зависимости после опиодной детоксикации.\u003Cbr\u003EКомплексная терапия алкоголизма, в том числе при поддерживающей терапии, в тех же дозировках, что и при героиновой зависимости на фоне психотерапии."},{"name":"Противопоказания","value":"Пациенты, имеющие зависимость от опиоидов, в том числе находящиеся на лечении опиоидными агонистами или частичными агонистами. Положительная налоксоновая проба. Применение опиоидных анальгетиков или положительный анализ на содержание в моче опиоидов. Положительный тест на наличие опиоидов в моче. Опиоидный абстинентный синдром. Гиперчувствительность к компонентам препарата. Острый гепатит или печеночная недостаточность. Дефицит лактазы, непереносимость лактозы. Глюкозо-галактозная мальабсорбция."},{"name":"Состав","value":"Одна капсула содержит:\u003Cbr\u003EДействующее вещество:\u003Cbr\u003Eналтрексона гидрохлорид в пересчете на 100 % вещество - 50,0 мг.\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003Eлактозы моногидрат - 98,5 мг, магния стеарат - 1,5 мг.\u003Cbr\u003EКапсула твердая желатиновая № 4 - 38,0 мг.\u003Cbr\u003EКорпус капсулы:\u003Cbr\u003Eтитана диоксид (Е 171) - 2 %, желатин до 100 %.\u003Cbr\u003EКрышечка капсулы:\u003Cbr\u003Eкраситель железа оксид желтый (Е 172) - 1,7143 %, титана диоксид (Е 171) -1 %, краситель индигокармин (Е 132) - 0,3 %, желатин до 100 %."},{"name":"Действующее вещество","value":"Налтрексон"},{"name":"Дозировка","value":"50 мг"},{"name":"Способ применения и дозы","value":"Лечение опиоидной зависимости.\u003Cbr\u003EФаза введения в курс терапии налтрексоном.\u003Cbr\u003EЛечение налтрексоном начинают после того, как пациент в течение 7-10 дней воздерживается от приема опиоидов (при отсутствии проявлений синдрома абстиненции). Воздержание от употребления опиоидов идентифицируют по показателям лабораторных исследований мочи на содержание опиоидов.\u003Cbr\u003EЛечение начинают при отрицательной провокационной пробе с 0,5 мг налоксона.\u003Cbr\u003EОписание налоксоновой пробы: пациенту необходимо ввести 0,2-0,4 мг налоксона внутривенно в течение 5 мин или в виде инъекции подкожно либо внутримышечно. Если нет реакции на введение налоксона в течение 15-30 мин, вводят вторую дозу препарата 0,4 мг внутривенно или 0,4-0,8 мг подкожно и наблюдают за реакцией. Проба считается положительной при выраженном мидриазе, изменении аффекта от благодушно-сонливого до дисфорического, поведенческих расстройствах, появлении признаков опийной абстиненции.\u003Cbr\u003EНалоксоновую пробу не проводят пациентам с симптомами абстиненции и при выявлении опиоидов в моче. Налоксоновую пробу можно повторить через 24 ч.\u003Cbr\u003EЛечение налтрексоном начинают с осторожностью, постепенно повышая дозу. Содержимое капсулы растворяют в 50 мл воды. Вначале назначают 25 мг налтрексона внутрь (содержится в 25 мл исходного раствора). Врачу следует контролировать акт проглатывания раствора препарата.\u003Cbr\u003EПоддерживающая терапия налтрексоном.\u003Cbr\u003EНа следующий день после введения начальной дозы налтрексон начинают назначать по 50 мг каждые 24 ч (применения налтрексона в указанной дозе достаточно для блокирования эффектов опиоидов, вводимых парентерально, например, 25 мг героина, введенного внутривенно).\u003Cbr\u003E100 мг налтрексона назначают каждые 2 дня или 150 мг каждые 3 дня.\u003Cbr\u003EЛечение алкоголизма.\u003Cbr\u003EВ составе комбинированной терапии.\u003Cbr\u003EЕжедневный прием 50 мг налтрексона, минимальный курс - 3 месяца. Лечение должно быть частью соответствующей программы устранения алкогольной зависимости. На протяжении курса лечения необходимо отслеживать приверженность всем компонентам лечения алкоголизма, влияющим на благоприятный исход. Медикаментозное лечение рекомендуется сопровождать курсом психотерапии."},{"name":"Побочные действия","value":"Классификация ВОЗ неблагоприятных побочных реакций по частоте развития: очень часто - \u003E1/10; часто - от 1/100 до 1/10; нечасто - от 1/1000 до 1/100; редко - от 1/10000 до 1/1000; очень редко - \u003C1/10000, включая отдельные сообщения.\u003Cbr\u003EВ терапевтических дозах у пациентов, в организме которых не содержаться опиоиды, налтрексон обычно не вызывает серьезных побочных эффектов.\u003Cbr\u003EСо стороны пищеварительной системы: очень часто - тошнота и/или рвота, боль в животе; часто - абдоминальная боль, снижение или повышение аппетита, анорексия, диарея или запоры, сухость слизистой оболочки полости рта, метеоризм, повышение активности \"печеночных\" ферментов, редко - усугубление симптомов геморроя, эрозивно-язвенные поражения желудочно-кишечного тракта.\u003Cbr\u003EСо стороны нервной системы и органов чувств: очень часто - беспокойство, нервозность, необычная усталость, общая слабость, беспокойный сон, \"кошмарные\" сновидения, головная боль; часто - головокружение, нечеткость зрительного восприятия, спутанность сознания, галлюцинации, угнетение центральной нервной системы, редко - депрессия, бред, звон и ощущение заложенности в ушах, боль и чувство жжения в глазах, светобоязнь, раздражительность, сонливость, дезориентация во времени и пространстве, мигрень, обморок, астения, летаргия, тревога.\u003Cbr\u003EСо стороны дыхательной системы: не часто - кашель, охриплость голоса, заложенность носа (гиперемия сосудов носовой полости), затруднение дыхания, зуд в носу, ринорея, чиханье, бронхообструкция, затруднение дыхания, одышка, носовое кровотечение, сухость в горле, повышенное отделение слизистой мокроты, инфекции верхних дыхательных путей, синусит, ларингит, фарингит (в т.ч. стрептококковый), назофарингит, гайморит.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: не часто - боль в груди, повышение артериального давления, тахикардия, сердцебиение, неспецифические изменения на электрокардиограмме, флебит.\u003Cbr\u003EСо стороны органов зрения: редко - конъюнктивит.\u003Cbr\u003EСо стороны мочеполовой системы: часто - сексуальные расстройства у мужчин (задержка эякуляции, снижение потенции), повышение или снижение либидо, не часто - дискомфорт при мочеиспускании, учащение мочеиспускания, отечный синдром (отек лица, пальцев, стоп, голеней).\u003Cbr\u003EАллергические реакции: часто - кожная сыпь, гиперемия кожи (в т.ч. гиперемия лица), гипертермия, кожный зуд, повышение секреции сальных желез, озноб.\u003Cbr\u003EСо стороны опорно-двигательного аппарата: очень часто - боль в спине, скованность суставов, боль в конечностях, спазм, подергивание или скованность мышц; часто - артралгия, миалгия; артрит.\u003Cbr\u003EСо стороны кожных покровов: папулезная сыпь, потница, угри, алопеция. Прочие: сухость во рту или жажда, боль в горле, увеличение или потеря массы тела, боль в паховой области, увеличение лимфатических узлов, лимфо- цитоз; в одном случае описано развитие идиопатической тромбоцитопениче- ской пурпуры на фоне предварительной сенсибилизации к препарату.\u003Cbr\u003EСиндром \"отмены\" опиоидов: абдоминальная боль, спазмы в эпигастральной области, беспокойство, нервозность, усталость, раздражительность, диарея, тахикардия, гипертермия, ринорея, чиханье, \"гусиная кожа\", потливость, зевота, артралгия, тошнота и /или рвота, тремор, общая слабость.\u003Cbr\u003EЕсли любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу.\u003Cbr\u003EПострегистрационный опыт применения\u003Cbr\u003EПо литературным данным описан единичный случай идиопатической тромбо- цитопенической пурпуры у пациента, который возможно, был сенсибилизирован к налтрексону в ходе предыдущего лечения. Выздоровление произошло после отмены препарата и проведения курса кортикостероидной терапии."},{"name":"Фармакологическое действие","value":"Налтрексон является чистым антагонистом опиоидных рецепторов. Конкурентно связывается с опиоидными рецепторами всех типов и предупреждает или устраняет действие как эндогенных опиоидов, так и экзогенных опиоидных препаратов - опиоидных анальгетиков и их суррогатов. Наибольшее сродство имеет к μ- и k-рецепторам. Снижает эффект опиоидных анальгетиков (анальгетический, противодиарейный, противокашлевой); устраняет побочные эффекты опиоидов (в т.ч. эндогенных), за исключением симптомов, обусловленных гистаминовой реакцией. В сравнении с налоксоном действует более сильно и длительно. Может вызвать миоз (механизм неизвестен). Сочетание с опиоидами в больших дозах приводит к повышению высвобождения гистамина с характерной клинической картиной (гиперемия лица, зуд, сыпь). У пациентов с опиоидной зависимостью вызывает приступ абстиненции.\u003Cbr\u003EНалтрексон не вызывает дисульфирам-подобные реакции, как в результате употребления опиоидов и этанола. При алкоголизме связывается с опиоидными рецепторами и блокирует эффекты эндорфинов. Снижает потребность в алкоголе и предотвращает рецидивы в течение 6 месяцев после 12-недельного курса терапии (успех лечения зависит от согласия пациента). Длительное назначение не вызывает толерантности и зависимости.\u003Cbr\u003EПри одновременном длительном назначении предупреждает развитие физической зависимости к морфину, героину и другим опиоидам. В дозе 50 мг блокирует фармакологические эффекты 25 мг внутривенно введенного героина в течение 24 ч, двойная доза (100 мг) - в течение 48 ч, а 150 мг - в течение 3 суток. Конкурентная блокада опиоидных рецепторов может быть преодолена введением более высокой дозы опиоидного анальгетика."},{"name":"Фармакологическая группа","value":"опиоидных рецепторов антагонист"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте при температуре не выше 25 °С. Хранить в местах, недоступных для детей."},{"name":"Передозировка","value":"Налтрексон является умеренно безопасным препаратом. Согласно исследованиям, даже большие дозы не вызывают серьезных симптомов. При подозрении на интоксикацию следует назначить симптоматическое лечение.\u003Cbr\u003EНа этапе доклинического исследования при повторном введении налтрексона в дозе 100 мг/кг, превышающей максимальную суточную дозу для человека примерно в 35 раз, не выявлено каких-либо существенных изменений в гематологических и биохимических показателях крови, а также в структуре внутренних органов. Местно-раздражающее действие налтрексон также не оказывает."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат по степени токсичности относится к категории С.\u003Cbr\u003EВ экспериментах на крысах (прием в дозах, в 30 раз превышающих рекомендуемые для людей непосредственно перед беременностью и во время беременности) и на кроликах (прием в дозах, в 60 раз превышающих рекомендуемые для людей) установлено наличие тератогенного эффекта.\u003Cbr\u003EПрименение препарата при беременности возможно только в случае, если потенциальная польза от его применения превышает потенциальный риск для плода.\u003Cbr\u003EПри пероральном приеме налтрексона было отмечено выделение налтрексо- на и 6-бета-налтрексола с грудным молоком. Из-за потенциальной канцерогенности и вероятности возникновения у грудных детей серьезных побочных явлений, следует принять решение о прекращении терапии препаратом во время кормления грудью или прекращении грудного вскармливания во время лечения препаратом, в зависимости от степени важности терапии для матери."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"Налтрексон эффективен только в составе комплексной терапии зависимости. Перед применением необходимо исключить субклиническую печеночную недостаточность, во время лечения следует периодически контролировать транзиторное повышение активности трансаминаз.\u003Cbr\u003EНалтрексон оказывает гепатотоксическое действие. Поэтому при длительном применении необходимо контролировать функцию печени.\u003Cbr\u003EНалтрексон назначают только после купирования абстинентного синдрома.\u003Cbr\u003EПрепарат начинают принимать только в специализированных учреждениях под контролем врача. Следует внимательно следить за появлением признаков депрессии или суицидальных мыслей у пациентов с алкогольной и/или опиодной зависимостью, в том числе пациентов, получающих лечение нал- трексоном. Членов семей и ухаживающих за пациентами людей следует предупредить о необходимости внимательно следить за возникновением симптомов депрессии или суицидального поведения и немедленно сообщать о возникновении таких симптомов лечащему врачу. Для обеспечения эффективности лечения необходимо проведение комплексной терапии, включающей психологическую поддержку.\u003Cbr\u003EНалтрексон блокирует действие опиоидов. Блокада может быть преодолена повышением доз опиоидов.\u003Cbr\u003EПациента, который получает лечение налтрексоном, следует предупредить о том, что неконтролируемый прием опиоидов в этот период может привести к тяжелому синдрому абстиненции вплоть до развития комы. Существует риск летального исхода.\u003Cbr\u003EНалтрексон оказывает гепатотоксическое действие. Поэтому при длительном применении необходимо контролировать функцию печени.\u003Cbr\u003EНалтрексон необходимо отменить не менее чем за 48 ч до хирургического вмешательства, при котором потребуется применение опиоидных анальгетиков. В случае необходимости проведения экстренной анальгезии с осторожностью назначают опиоиды в повышенной дозе (для преодоления антагонизма), поскольку угнетение дыхания при этом будет более глубоким и продолжительным. Для предотвращения развития острого абстинентного синдрома пациенты должны как минимум за 7-10 дней прекратить прием опиоидов и лекарственных средств, их содержащих, обязательно определение опиоидов в моче и проведение провокационного теста с налоксоном; при несоблюдении этих требований может проявиться абстинентный синдром.\u003Cbr\u003EСтойкое снижение аппетита и прогрессирующее похудание требуют прекращения терапии.\u003Cbr\u003EНеэффективен при лечении кокаиновой, а также неопиоидной лекарственной зависимости.\u003Cbr\u003EВозможно развитие эозинофильной пневмонии, резистентной к антибиотико- терапии; при развитии прогрессирующей одышки и гипоксии необходимо немедленно обратиться к врачу.\u003Cbr\u003EСледует предупреждать пациентов, что:\u003Cbr\u003E- при обращении за медицинской помощью пациенты обязаны информировать медицинских работников о лечении налтрексоном;\u003Cbr\u003E- в случае появления болей в животе, потемнения мочи, пожелтения склер необходимо прекратить прием и обратиться к врачу;\u003Cbr\u003E- при самостоятельном употреблении героина и других опиоидов в малых дозах эффекта от их применения не будет, а дальнейшее увеличение дозы опио- идных средств приведет к летальному исходу (остановка дыхания).\u003Cbr\u003EС осторожностью:\u003Cbr\u003EНарушения функции печени и/или почек."},{"name":"Взаимодействие","value":"Снижает эффективность лекарственных средств, содержащих опиоиды (про- тивокашлевые лекарственные средства, опиоидные анальгетики, противопростудные препараты). Там, где возможно, должны использоваться альтернативные препараты.\u003Cbr\u003EГепатотоксические лекарственные средства увеличивают (взаимно) риск поражения печени.\u003Cbr\u003EДисульфирам ингибирует микросомальное окисление в печени, вследствие чего может вызвать повышение концентрации препаратов в плазме крови, метаболизирующихся в печени (налтрексон), что увеличивает риск интоксикации.\u003Cbr\u003EВозможна летаргия или повышенная сонливость при сочетании с тиоридазином. Ускоряет появление симптомов синдрома \"отмены\" на фоне опиоидной зависимости, характеризующихся стойкостью и трудностью их устранения."},{"name":"Регистрационный номер","value":"ЛП-002591"},{"name":"Дата государственной регистрации","value":"22.11.2021"},{"name":"Владелец регистрационного удостоверения","value":"Московский эндокринный завод"},{"name":"Изготовитель","value":"Московский эндокринный завод"},{"name":"Фасовщик","value":"Московский эндокринный завод"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Налтрексон"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_10016869577416607800"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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  • Коррида таб., 60 г, 100 шт., 1 уп., нейтральный
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-vyvhvr01028/toggleWishlist":{"skuId":"265133266","productId":1778173855,"offerId":"-6IIuDxBwdOk4LVg9dDAhQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIn4/zzwYQ0rm2fhjVu6EGIKXawQc=","sign":"F35kwEvAJZxKXXMzh3gLqI+7DWLIAeGJcHxAl/Yj/xQ="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-vyvhvr01028/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Коррида таб., 60 г, 100 шт., 1 уп., нейтральный

    Рейтинг товара: 3.9 из 5
    на основе 416 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 428 ₽ вместо 432
    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  • Зиналпро капс., 10 шт.
    –44 %
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    Зиналпро капс., 10 шт.

    Рейтинг товара: 4.6 из 5
    на основе 68 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 336 ₽ вместо 346
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  • Фунго-Ши Копринус капс., 60 шт.
    –1 %
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    Фунго-Ши Копринус капс., 60 шт.

    Рейтинг товара: 4.4 из 5
    на основе 8 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 777 ₽ вместо 785
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  • Мидзо капли д/вн. приема, 60 мг/мл, 15 мл, 4 шт.
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    Мидзо капли д/вн. приема, 60 мг/мл, 15 мл, 4 шт.

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 2 299 ₽
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  • Метадоксил таб., 500 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7xlcrmcikjb/toggleWishlist":{"skuId":"227814297","productId":1778173845,"offerId":"Mjq0Rbxb98CpQqgGg-DsSA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIlY/zzwYQmdfQbBj2w9kHIKXawQc=","sign":"dSjQdPM3L9wcr9g/6sv9TnPRdcPcOMChvGA1FS+8+c8="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-7xlcrmcikjb/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Метадоксил таб., 500 мг, 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 13 оценок
    Цена 2 829 ₽
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  • Тетурам таб., 150 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pb25kow0fei/toggleWishlist":{"skuId":"101635371729","productId":641057654,"offerId":"-8PWBdCN3rNtEgxUq8w0lA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI9obXsQIQ0eXCz/oCGI+83gcgpdrBBw==","sign":"ZxVCr3XYSQK7upPxWfHzb6mDwgPVOUlr/zRUbNswYhQ="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-pb25kow0fei/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тетурам таб., 150 мг, 30 шт.

    Рейтинг товара: 5 из 5
    на основе 17 оценок
    Цена 349 ₽
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  • Тетурам таб., 150 мг, 50 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-smtzuj8xy3/toggleWishlist":{"skuId":"661252007","productId":1436729424,"offerId":"ZHmFKIso4pIDIH0ZOQq-cQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYI0ICLrQUQp8+nuwIY68v1ByCl2sEH","sign":"irBPPeqZNTotMwAyXpC/lcB7V3oTwC6FVYmeDurt8+Y="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-smtzuj8xy3/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тетурам таб., 150 мг, 50 шт.

    Рейтинг товара: 5 из 5
    на основе 9 оценок
    Цена 405 ₽
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  • Табакетте таб. п/о плен., 1.5 мг, 100 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fy11a4g42a/toggleWishlist":{"skuId":"101871454079","productId":1784713457,"offerId":"KMut-8t1z1B2bL1mBDGP8A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI8aGC0wYQ/46MwPsCGK7e0AcgpdrBBw==","sign":"RVx3TExhzx4zgOH7SwSbe/SfaVt59F46ZuKJKHaiOfg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fy11a4g42a/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Табакетте таб. п/о плен., 1.5 мг, 100 шт.

    Рейтинг товара: 4.6 из 5
    на основе 50 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 892 ₽ вместо 901
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fy11a4g42a/addToCartButton":{"offerId":"KMut-8t1z1B2bL1mBDGP8A","skuId":"101871454079","pendingCartItem":{"productId":1784713457,"offerId":"KMut-8t1z1B2bL1mBDGP8A","showPlaceId":"OTNDnItfwRMjN9MRHuEMMnFFQOCMYdRj7nuIfhnzGZCdgFO_uLP6aDo-DqBu7oxw_9c68-RolXsAxG6P1fTSGlBB5xZ2mzihOUd8PdPCyrUFZlL_5Zo4MyxLDMvr__BTDtQu68G93K5uqYeufshIeNQ6cR6SVwhTLTFQ0Iy8GQoiiU6btANYanuYqsWIALcaoNRzpjCsJq3a6XEfBhRI0Q,,","feeShow":"OTNDnItfwRMjN9MRHuEMMnFFQOCMYdRj7nuIfhnzGZCdgFO_uLP6aDo-DqBu7oxw_9c68-RolXsAxG6P1fTSGlBB5xZ2mzihOUd8PdPCyrUFZlL_5Zo4MyxLDMvr__BTDtQu68G93K5uqYeufshIeNQ6cR6SVwhTLTFQ0Iy8GQoiiU6btANYanuYqsWIALcaoNRzpjCsJq3a6XEfBhRI0Q,,","skuId":"101871454079","shopId":431782,"price":{"applicablePriceDiscounts":[{"priceWithDiscount":"892","type":"ya-card","totalPercentWithDiscount":1}],"value":"901","currency":"RUR"},"hid":"15756581","name":"Табакетте таб. п/о плен., 1.5 мг, 100 шт.","label":"yc5sy99wjws","count":0,"features":[],"imageMeta":{"namespace":"mpic","groupId":5288893,"key":"img_id4301233085741360519.jpeg"}},"quantity":{"step":1,"minimum":1,"maximum":999},"cpaUrl":"/safeclick/data=TxNGOK9vJEN7oLFLeCTKEixJYuEMI0EzvZFs82AjjgjhTwweZ7mRXd_AQ0K184sfZmy5nQz7U8xIc-qdVOMFoxnoSww2ObzLEs1KJpltGipDSanCui6QCo8GXRHxAQaqQQZbzp5kb0bdQDXqQiIIDEwL4INEBUjrbUNtjxqZ96WFVmZtSFtMyb3yJJ0vvI_f_VoLwr8_fQB9q2GjoS0PACEDxloPuPS4HgT6tV-a97sPXA05RxbLAEOcuTN7mxJ3kYOjX6kkR_HpALbUnziEtgwSaB2dL3mwO-NNiEzHoalPdS5D9wz_mySoaneDBNgRfkS9RZRZGXGLeHzYhx162ZKKoTx9Pn9YwiUWcyEMZIBKE5A7rdcUvO0UFXnCAK22BjvifBtlcTJUKiN17ySY8QKu9wqgWno1J9xqa3rnp2DNY-MHgZN47v1KS4XFmnM8RFsjRwCeVqaNPG0lbjdDnPaXaID9ESJ6xeLKF22nGB_znClEnPWhiKEM-SKTA-3M-3CfvdVOmtfyTdaCUC1UUu1F_MTDL9Q-T25ezFEI5TtqiXZOdHrrgzFivgS9ZN_TXqcfH9A1fQ7DzAmuaBXt9gf5ijacjRPJl79Hbf9lhAbcb-ATTNnnj9jNDgXHswdeX0PRSRip4zpWOCkCS8QFys-YGH6ubDryz_hOm_mu6AijXU3EMncxlFf6mWDEZslqUV6OkEpMqN0fD6ztKT_UaLHLEcoZO4_RukdGO4vhSXT77t3FHW_x702UZ-5BMQIJQNZtalhVuIoC7X0AsO9A9p2Vo8GltHj6PTnQEAErej5p4cEJmGMKR6J7-Zc4VObCSkHM8YHJOanfVITsGlPd40ukhMc_kdqVC7w_bAn_KV2HgmMMqVY0SyEBXjW53Y65kp7201iHlKrheMHXc0bH6AKsFo1im8tDMorSSXEsRMy4ZBbqymP7SSY9qy1ZXavJRy46e-L3d9mJt4MvOqR_zmWm9-z9jvLu31eCPot9ldcxnww_be8T6aw02aBw5MnfmWBN4SRip8pvWvACPv4HMXOlOOoyLdtXaqx_8LRv7Q1pEFjcKiCgGWhFEXyiT-6bqQz3p8xj79-l017pW5mQEZ1fO4wLtVE8qA2OcWxoDlfnkLRMEwKHE-fvcqGvAAclDy6PWMJAJzwWAzMSm6UvY3TK1mDkpwku8VOumxCQAIM_qacKE_2j3cU64YlfdxryNV9alTkABxRugX3vYrLrOLpY4ksd7Q8I9RYVz5Q763K1d0cj0MxaxeCJWRo1S8szaEzrZ_RUBP-INmetB9nqRgDnwdZiBJzrqWZD-m5E7kZNXGc9W2Mcq0r_WONW5rsWwh9J75ih9Kr8LEWmjL6XUkgPY4usXfXDyOHMdoOQQfk4ggLipWp1EOSX3REerhw04W5roHu0pgdUkNnSrQkxmpkpivA-Sd1rzIqRvpMnDIbMv6tdmA3rr0JBzqHxuBGFRqwmrsTI7IAiCFuFi06hcinwiyzdZ9MFoSf09G-dx8USE-4ZIYHNkuRpNdY2lhf4OiHU124OFTk1LuJRjKja6xRRfC6gO4tWwmqju7kiQxHIxAm5j9OS0I2wz7ftUqg_l3Jmu-M3WpBUKsriBW_vDyY47MwiDfwzq4ZpaLBSp8H1JQK1CJrvpPKoNai-cwqn7krBLkhgoeibIurrGHKoAglKJG6g9PDDICeUNHwbK3BPBMzwLCz1YNsXH5Y3v9q93FQrudxpHkRHOHmM_ykeazfrSjk4NWVw57KP98R8X_GZ6KAUTsaXBAIMVX-3m0ArSRDuITBTEJVWydFVd5siKSqlzd9xkRyDsmN9V8iiHNy-t5K3UEdkhKX8Wxyh8QNzoXemHQlnUH25vWqfmwDFcCRYQVJcbUz0AjvPZB_6T9-bcN2YcBj1Dd26sRkEsF16VxJlEggCowigvEnX5KUjTIDvab1UxDWp1cnrvogZyQ27qocqlEh6iQG8cgGcwZMAJgP1nTRlxAwmiufGO00ce7ZCvS8WQB9RzEgASgmP-mIREdKwq1msOVRK57oBfnfKxvGd11lvHGvRuvaPHGS-9vY_QZBws7wl-jXjGwU9Wrtv-wsnWRmWfzKPQguygk6WuonbU6nQnv0C2cTituqXzt7PLO0OgiBDpwx6f7WaGSpKVcZbe42S-iPluxJw6FriTLVYP_-rnWatThJyXOLC-nCVudc0JmfydPJ5hepZVbl-gvt1EzKCcspGDfOwH15Rjng6ykN_G-O-mlGpZ-8OCqe2ID-VCVh8P5PgJcipSC_4ivYaD1Qzbyz9O-2MzRBRNqBitwCauj4ICTjWG1nUGe6CR6pemB6pekSWbCjog7iPFM01hWj21Q6aA0GsTaCr1Aj_QeIMjJarQM9n-mydD4JNdjxDVt2Q9MfMoVlc53UjQ1XXLAkwQyCwlvaKOhUKQ46IuCvjivELCfo9QKbU_KKVDHKEHBR-oFoqvgyTv1IOENVoHzmiciEtnbNMZnscN6P0yA1Tgbs-IpxmAGEGcCB3gKU-oa2TuAmxQEN_xMkjLwSCHWkJ5wrc_Q4fT0x7qPbEPCz9L-jSc2tLNiPPKXAo1TgKrn5x60DPhfCwPzBylWKSx3MJo0G1ug7uoT15k9_IUcmAkgHRuwcWJqbcgj4orvb2cicyBAvoEBcx7Hncr2x7KRsa7_VypJN9rilg33ayAMgOiR5BoozaoTOqnUXa0qhHoHmBUCQs0OkLeUpv1tYTN1q0cQdahZw81RVxsPuBRm3rCZ5XX1Izi5h4gA-z1FCPu0J8s7zfOr-2EmYCUN94TGK_lqPtTCkrbYx-ISFcdLJV8fEtQ8KDfNft6VAH045nWyrRZnNOHJ2N1J2Vm-gCnq1hOUtWytBKewuykMbnFMb_U4l2UDbXqMij8QK6uVvbHQPrfhm5yO0MSR86Ijy24utM4TmXUq1jLz1Dn79091ErrLtCxv2zYUsgqX7w00zxy7AoeBT2cfQKCogylx-L2GJRd50OXjPHBvucp0eYTdg7tY6ceIEq3noMFLsJ-NN_xxCnWzpNrIEwmFmyYvum0UPBI3F3SRSFm7WFx1ddByc-_x3iFfbnr106Ct8XA3SrnWy5hh6No-dry8VePxY3vBLs824kxzAwN4ITqXL85UILhoXXtfwZjtnP5ZBJ6JV2H6hvMpZB3ity2IIbyOsNv8ii6HAU8-CK6FX5tHXfZHj-x5M5Jb5W0lbRTIkT_O2UPN8pmiyUASOeOVOk7ZSiBLM5TbWxuDq2fwt0rL2IZxGaBH_CoqfHBeixHzDymnWOVXvQxu61GjQiAMh6KCrXjL_jTGt_xD8_-J5udrRfRHchEpqEPeNb4N0VXDMrzrpWdUG0WvCMB9qlbaI,/b64e=1/sign=5bd432ef62ef4c64d4a0a07547742628/keyno=MARKET_1/*","showUid":"17183215883435346835206008","cartLink":"/my/cart","showNotificationWhenDeleteItem":true,"isLavka":false,"isError":false,"isEats":false,"isCR":false,"isM2bEdoOnlyEnable":false,"isEatsMarketIntegration":true,"isCartButtonNext":false,"isUpsalePopupCRExp":false,"baobabClientDataAdditionToCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI8aGC0wYQ/46MwPsCGK7e0AcgpdrBBw==","sign":"RVx3TExhzx4zgOH7SwSbe/SfaVt59F46ZuKJKHaiOfg="},"target":"cart_addition"},"baobabClientDataDeletionFromCart":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI8aGC0wYQ/46MwPsCGK7e0AcgpdrBBw==","sign":"RVx3TExhzx4zgOH7SwSbe/SfaVt59F46ZuKJKHaiOfg="},"target":"cart_deletion"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fy11a4g42a/addToCartButton":{"name":"@light/AddToCartButtonSnippet"}}}
  • Пропротен-100 таб. д/рассас., 20 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-uph26essiud/toggleWishlist":{"skuId":"228071596","productId":1436729422,"offerId":"jZMXSM4f_j7YQWFB5J0qBw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIzoCLrQUQrLHgbBiq4NAHIKXawQc=","sign":"NQwdCMNsYezoamW92n+PB+hFYBfPBN9b3obtxcFISBg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-uph26essiud/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пропротен-100 таб. д/рассас., 20 шт.

    Рейтинг товара: 4.5 из 5
    на основе 32 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 262 ₽ вместо 265
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  • Алкодетокс таб. п/о, 10 шт., 1 уп.
    –1 %
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    Алкодетокс таб. п/о, 10 шт., 1 уп.

    Рейтинг товара: 5 из 5
    на основе 3 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 347 ₽ вместо 350
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  • Табекс таб. п/о плен., 1.5 мг, 100 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-sgp9v7xi1vn/toggleWishlist":{"skuId":"227830474","productId":1776700311,"offerId":"UpufeYN6CNytNQuf_WJUgw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhUIl5eZzwYQytXRbBiG4NAHIKXawQc=","sign":"KiMjmrIYFJTNDXk+jYsI3xzFIs7nRzAtewA30TBzwHk="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-sgp9v7xi1vn/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Табекс таб. п/о плен., 1.5 мг, 100 шт.

    Рейтинг товара: 4.7 из 5
    на основе 635 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 480 ₽ вместо 1 495
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  • Тетурам таб., 150 мг, 50 шт.
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    Тетурам таб., 150 мг, 50 шт.

    Рейтинг товара: 4.5 из 5
    на основе 8 оценок
    Цена 408 ₽
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Инструкция

Показания к применению

Лечение алкогольной зависимости и блокада эффектов экзогенно введенных опиоидов.
Комплексная терапия опиоидной зависимости с целью поддержания у пациента состояния, при котором опиоиды не смогут оказать характерного действия.
Лекарственный препарат показан для предотвращения рецидива опиоидной зависимости после опиодной детоксикации.
Комплексная терапия алкоголизма, в том числе при поддерживающей терапии, в тех же дозировках, что и при героиновой зависимости на фоне психотерапии.

Противопоказания

Пациенты, имеющие зависимость от опиоидов, в том числе находящиеся на лечении опиоидными агонистами или частичными агонистами. Положительная налоксоновая проба. Применение опиоидных анальгетиков или положительный анализ на содержание в моче опиоидов. Положительный тест на наличие опиоидов в моче. Опиоидный абстинентный синдром. Гиперчувствительность к компонентам препарата. Острый гепатит или печеночная недостаточность. Дефицит лактазы, непереносимость лактозы. Глюкозо-галактозная мальабсорбция.

Способ применения и дозы

Лечение опиоидной зависимости.
Фаза введения в курс терапии налтрексоном.
Лечение налтрексоном начинают после того, как пациент в течение 7-10 дней воздерживается от приема опиоидов (при отсутствии проявлений синдрома абстиненции). Воздержание от употребления опиоидов идентифицируют по показателям лабораторных исследований мочи на содержание опиоидов.
Лечение начинают при отрицательной провокационной пробе с 0,5 мг налоксона.
Описание налоксоновой пробы: пациенту необходимо ввести 0,2-0,4 мг налоксона внутривенно в течение 5 мин или в виде инъекции подкожно либо внутримышечно. Если нет реакции на введение налоксона в течение 15-30 мин, вводят вторую дозу препарата 0,4 мг внутривенно или 0,4-0,8 мг подкожно и наблюдают за реакцией. Проба считается положительной при выраженном мидриазе, изменении аффекта от благодушно-сонливого до дисфорического, поведенческих расстройствах, появлении признаков опийной абстиненции.
Налоксоновую пробу не проводят пациентам с симптомами абстиненции и при выявлении опиоидов в моче. Налоксоновую пробу можно повторить через 24 ч.
Лечение налтрексоном начинают с осторожностью, постепенно повышая дозу. Содержимое капсулы растворяют в 50 мл воды. Вначале назначают 25 мг налтрексона внутрь (содержится в 25 мл исходного раствора). Врачу следует контролировать акт проглатывания раствора препарата.
Поддерживающая терапия налтрексоном.
На следующий день после введения начальной дозы налтрексон начинают назначать по 50 мг каждые 24 ч (применения налтрексона в указанной дозе достаточно для блокирования эффектов опиоидов, вводимых парентерально, например, 25 мг героина, введенного внутривенно).
100 мг налтрексона назначают каждые 2 дня или 150 мг каждые 3 дня.
Лечение алкоголизма.
В составе комбинированной терапии.
Ежедневный прием 50 мг налтрексона, минимальный курс - 3 месяца. Лечение должно быть частью соответствующей программы устранения алкогольной зависимости. На протяжении курса лечения необходимо отслеживать приверженность всем компонентам лечения алкоголизма, влияющим на благоприятный исход. Медикаментозное лечение рекомендуется сопровождать курсом психотерапии.
Полная инструкция
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Налтрексон капс.
Налтрексон капс., 50 мг, 10 шт.
5.0
(2)
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3 вопроса
Инструкция

1 196 ₽

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5.0
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    Таблетница, 14 секций (007751)

    Цена 218 ₽ вместо 415
  • Мидзо капли д/вн. приема, 60 мг/мл, 15 мл, 4 шт.
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    Мидзо капли д/вн. приема, 60 мг/мл, 15 мл, 4 шт.

    Цена 2 299 ₽
  • Метадоксил таб., 500 мг, 30 шт.
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    Метадоксил таб., 500 мг, 30 шт.

    Цена 2 829 ₽
  • Таблетница органайзер на неделю, контейнер для таблеток, бокс, на 7 дней, 4 приема, 28 ячеек
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    Таблетница органайзер на неделю, контейнер для таблеток, бокс, на 7 дней, 4 приема, 28 ячеек

    Цена 361 ₽ вместо 690
  • Таблетница на 7 дней Органайзер для лекарств
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    Таблетница на 7 дней Органайзер для лекарств

    Цена 273 ₽ вместо 279
  • Таблетница на день мини для капсул контейнер для таблеток белый
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    Таблетница на день мини для капсул контейнер для таблеток белый

    Цена 282 ₽ вместо 750
  • VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер
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    VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер

    Цена 245 ₽ вместо 1 400
  • Тетурам таб., 150 мг, 30 шт.
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    Тетурам таб., 150 мг, 30 шт.

    Цена 349 ₽
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    Реклама
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  • Тетурам таб., 150 мг, 50 шт.
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    Тетурам таб., 150 мг, 50 шт.

    Цена 405 ₽
  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1697098837_10/content/content/gallery":{"title":"Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5232043/img_id7017230458924859337.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1697098837_10/content/content/toggleWishlist":{"skuId":"101610320198","productId":1697098837,"offerId":"aS77pnTlGEnfCAS-2gxsfg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCNXYnqkGEMbiycP6AhiS9vcHIM3OPQ==","sign":"OAQAzeCVIQ7o1mcZI5X1arR8TJe6c7ZdAku4o2xupAs="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1697098837_10/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)

    Цена 245 ₽ вместо 263
  • Табакетте таб. п/о плен., 1.5 мг, 100 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1784713457_11/content/content/toggleWishlist":{"skuId":"101871454079","productId":1784713457,"offerId":"KMut-8t1z1B2bL1mBDGP8A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzdqgufbHzPc/EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCPGhgtMGEP+OjMD7Ahiu3tAHIKXawQc=","sign":"Dv6sMhCoYJ2cLpG8UC+VxTXc7op+2Fmuxf2zoAyXyOo="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1784713457_11/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Табакетте таб. п/о плен., 1.5 мг, 100 шт.

    Цена 892 ₽ вместо 901
  • Пропротен-100 таб. д/рассас., 20 шт.
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    Пропротен-100 таб. д/рассас., 20 шт.

    Цена 262 ₽ вместо 265
  • Алкодетокс таб. п/о, 10 шт., 1 уп.
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    Алкодетокс таб. п/о, 10 шт., 1 уп.

    Цена 347 ₽ вместо 350
  • Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

    Цена 209 ₽ вместо 599
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 457 ₽ вместо 637
  • Табекс таб. п/о плен., 1.5 мг, 100 шт.
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    Табекс таб. п/о плен., 1.5 мг, 100 шт.

    Цена 1 480 ₽ вместо 1 495
  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 176 ₽ вместо 350
  • Тетурам таб., 150 мг, 50 шт.
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    Тетурам таб., 150 мг, 50 шт.

    Цена 408 ₽
  • Зиналпро капс., 10 шт.
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    Зиналпро капс., 10 шт.

    Цена 336 ₽ вместо 598
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 773 ₽ вместо 1 890
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    Реклама
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  • Фунго-Ши Копринус капс., 60 шт.
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    Фунго-Ши Копринус капс., 60 шт.

    Цена 777 ₽ вместо 785
  • Контейнер для хранения/таблетница/кейс для таблеток
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    Контейнер для хранения/таблетница/кейс для таблеток

    Цена 489 ₽ вместо 699
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