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Описание

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Натрия тиосульфат р-р для в/в введ. амп., 300 мг/мл, 10 мл, 10 шт.

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4.9
(11)
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Коротко о товаре

Артикул Маркета
3123220470
Тип препарата
Рецептурный препарат
Назначение
Действующее вещество
Инструкция
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Лечение следует начинать как можно раньше после установления диагноза.\u003Cbr\u003EВзрослым вводят в разовой дозе 50 мл раствора, детям из расчета 250 мг/кг массы тела.\u003Cbr\u003EВ случае если симптомы отравления цианидами вновь возникают, необходимо повторить введение препарата в дозе, составляющей 50% от первоначальной.\u003Cbr\u003EВо время введения необходимо контролировать артериальное давление: в случае выраженного снижения артериального давления, необходимо уменьшить скорость введения."},{"name":"Побочные действия","value":"Поскольку строго контролируемые исследования по оценке профиля нежелательных явлений натрия тиосульфата отсутствуют, частота представленных побочных эффектов, сообщаемых в медицинской литературе, не может быть оценена.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы: снижение артериального давления.\u003Cbr\u003EНарушения со стороны нервной системы: головная боль, дезориентация, соленый привкус во рту, ощущение тепла по всему телу.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта: тошнота, рвота.\u003Cbr\u003EНарушения со стороны кровеносной системы: удлинение времени кровотечения.\u003Cbr\u003EПрочие: аллергические реакции.\u003Cbr\u003EБыстрое введение или введение больших доз натрия тиосульфата сопровождалось более высокой частотой развития тошноты и рвоты."},{"name":"Фармакологическое действие","value":"Натрия тиосульфат - комплексообразующее средство. При введении в организм оказывает дезинтоксикационное действие. Образует нетоксичные или малотоксичные соединения с цианидами.\u003Cbr\u003EОсновным механизмом детоксикации при отравлении синильной кислотой и ее солями (цианидами) является образование менее ядовитых роданистых соединений (тиоцианат) при участии фермента родоназы - тиосульфатцианидсератрансферазы (обнаружен во многих тканях, но максимальную активность проявляет в печени).\u003Cbr\u003EОрганизм человека обладает способностью к эндогенной детоксикации цианидов, однако родоназная система работает медленно, и при отравлении цианидом ее активности недостаточно для детоксикации, в связи с чем для ускорения реакции, катализируемой родоназой, необходимо введение в организм натрия тиосульфата, который является донатором серы."},{"name":"Фармакологическая группа","value":"комплексообразующее средство"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный","transition":{"type":"catalog","params":{"categorySlug":"vaktsiny-syvorotki-fagi-toksiny","categoryId":"15756921","navnodeId":"72514","glfilters":["35947170:36763748"]}}},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Данные по передозировке натрия тиосульфата ограничены. Пероральный прием 3 г натрия тиосульфата в сутки в течение 1-2 недель у человека сопровождался снижением степени насыщения артериальной крови кислородом ниже 75%, что было связано со сдвигом вправо кривой диссоциации кислорода и гемоглобина. Восстановление степени насыщения артериальной крови кислородом к исходному уровню наблюдалось через 1 неделю после прекращения введения натрия тиосульфата. Сообщалось, что однократное введение 20 мл 20% раствора натрия тиосульфата не изменяло показатели насыщения крови кислородом."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватные и строго контролируемые исследования у беременных женщин отсутствуют. Применение натрия тиосульфата во время беременности возможно, если потенциальная польза для матери превышает потенциальный риск для плода. В проведенных эпидемиологических исследованиях не зарегистрировано врожденных аномалий у детей, рожденных от матерей, принимавших натрия тиосульфат во время беременности.\u003Cbr\u003EНеизвестно, проникает ли натрия тиосульфат в грудное молоко. Поскольку натрия тиосульфат вводят только при жизнеугрожающих состояниях, кормление грудью не является противопоказанием к его применению. В связи с тем, что многие препараты проникают в грудное молоко, следует соблюдать осторожность при применении натрия тиосульфата у кормящих женщин. Отсутствуют какие-либо данные по времени безопасного возобновления грудного вскармливания после введения натрия тиосульфата."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при управлении автомобилем и занятии потенциально опасными видами деятельности, требующими концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"При отравлении цианидами рекомендуется одновременное назначение натрия нитрита, при этом натрия тиосульфат вводится после натрия нитрита.\u003Cbr\u003EПри интоксикации цианидами следует избегать промедления при введении антидота (возможен быстрый летальный исход). Необходимо тщательно наблюдать за пациентом в течение 24-48 ч ввиду возможного возврата симптомов отравления цианидами. В случае возобновления симптомов введение натрия тиосульфата следует повторить в половинной дозе.\u003Cbr\u003EВ период лечения необходимо контролировать показатель гемоглобина и гематокрита.\u003Cbr\u003EПри наличии метгемоглобинемии измерения насыщения кислородом с использованием стандартных методик пульсоксиметрии и расчетных значений насыщения кислородом на основе измеренного РО2 ненадежны.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EПочечная недостаточность (замедленное выведение образующихся соединений), пожилой возраст (вследствие возможного нарушения функции почек), детский возраст до 18 лет (клинические исследования по оценке безопасности и эффективности натрия тиосульфата в педиатрической популяции отсутствуют, однако имеются сообщения в медицинской литературе о применении натрия тиосульфата в сочетании с натрия нитритом у педиатрических пациентов при отравлении цианидами, в связи с чем рекомендации по дозированию для педиатрических пациентов основаны на теоретических расчетах потенциального детоксикационного действия антидота, путем экстраполяции данных из экспериментов на животных, а также небольшого количества историй болезни)."},{"name":"Взаимодействие","value":"Категорически нельзя допускать контакта натрия тиосульфата с нитратами, перманганатом калия.\u003Cbr\u003EХимически несовместим с гидроксикобаламином, ввиду чего, их нельзя вводить через одно и то же устройство для внутривенного введения.\u003Cbr\u003EНе сообщалось о химической несовместимости натрия тиосульфата и натрия нитрита, вводимых последовательно через одну и ту же линию для внутривенного введения.\u003Cbr\u003EИсследования взаимодействия натрия тиосульфата с другими лекарственными средствами не проводились."},{"name":"Регистрационный номер","value":"ЛП-004638"},{"name":"Дата государственной регистрации","value":"17.01.2018"},{"name":"Владелец регистрационного удостоверения","value":"Дальхимфарм","transition":{"type":"catalog","params":{"categorySlug":"vaktsiny-syvorotki-fagi-toksiny","categoryId":"15756921","navnodeId":"72514","glfilters":["34324371:35649313","7893318:13877405"]}}},{"name":"Изготовитель","value":"Дальхимфарм"},{"name":"Фасовщик","value":"Дальхимфарм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Натрия тиосульфат","transition":{"type":"catalog","params":{"categorySlug":"vaktsiny-syvorotki-fagi-toksiny","categoryId":"15756921","navnodeId":"72514","glfilters":["17796364:17879192"]}}},{"name":"Срок годности","value":"48 мес."}]}},"fullSpecsGrouped":{"10544883403955730883":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат, антидот"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кровеносная система"},{"name":"Назначение","value":"интоксикация, острые отравления"},{"name":"Показания к применению","value":"В качестве антидота при отравлении цианидами."},{"name":"Противопоказания","value":"Гиперчувствительность к натрия тиосульфату."},{"name":"Состав","value":"Действующее вещество: натрия тиосульфата пентагидрат - 300 мг;\u003Cbr\u003EВспомогательные вещества: натрия гидрокарбонат - 20,0 мг, вода для инъекций - до 1 мл."},{"name":"Действующее вещество","value":"Натрия тиосульфат"},{"name":"Способ применения и дозы","value":"Внутривенно медленно. Лечение следует начинать как можно раньше после установления диагноза.\u003Cbr\u003EВзрослым вводят в разовой дозе 50 мл раствора, детям из расчета 250 мг/кг массы тела.\u003Cbr\u003EВ случае если симптомы отравления цианидами вновь возникают, необходимо повторить введение препарата в дозе, составляющей 50% от первоначальной.\u003Cbr\u003EВо время введения необходимо контролировать артериальное давление: в случае выраженного снижения артериального давления, необходимо уменьшить скорость введения."},{"name":"Побочные действия","value":"Поскольку строго контролируемые исследования по оценке профиля нежелательных явлений натрия тиосульфата отсутствуют, частота представленных побочных эффектов, сообщаемых в медицинской литературе, не может быть оценена.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы: снижение артериального давления.\u003Cbr\u003EНарушения со стороны нервной системы: головная боль, дезориентация, соленый привкус во рту, ощущение тепла по всему телу.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта: тошнота, рвота.\u003Cbr\u003EНарушения со стороны кровеносной системы: удлинение времени кровотечения.\u003Cbr\u003EПрочие: аллергические реакции.\u003Cbr\u003EБыстрое введение или введение больших доз натрия тиосульфата сопровождалось более высокой частотой развития тошноты и рвоты."},{"name":"Фармакологическое действие","value":"Натрия тиосульфат - комплексообразующее средство. При введении в организм оказывает дезинтоксикационное действие. Образует нетоксичные или малотоксичные соединения с цианидами.\u003Cbr\u003EОсновным механизмом детоксикации при отравлении синильной кислотой и ее солями (цианидами) является образование менее ядовитых роданистых соединений (тиоцианат) при участии фермента родоназы - тиосульфатцианидсератрансферазы (обнаружен во многих тканях, но максимальную активность проявляет в печени).\u003Cbr\u003EОрганизм человека обладает способностью к эндогенной детоксикации цианидов, однако родоназная система работает медленно, и при отравлении цианидом ее активности недостаточно для детоксикации, в связи с чем для ускорения реакции, катализируемой родоназой, необходимо введение в организм натрия тиосульфата, который является донатором серы."},{"name":"Фармакологическая группа","value":"комплексообразующее средство"},{"name":"Форма выпуска","value":"раствор для инъекций"},{"name":"Способ применения/введения","value":"парентеральный"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Данные по передозировке натрия тиосульфата ограничены. Пероральный прием 3 г натрия тиосульфата в сутки в течение 1-2 недель у человека сопровождался снижением степени насыщения артериальной крови кислородом ниже 75%, что было связано со сдвигом вправо кривой диссоциации кислорода и гемоглобина. Восстановление степени насыщения артериальной крови кислородом к исходному уровню наблюдалось через 1 неделю после прекращения введения натрия тиосульфата. Сообщалось, что однократное введение 20 мл 20% раствора натрия тиосульфата не изменяло показатели насыщения крови кислородом."},{"name":"Применение при беременности и кормлении грудью","value":"Адекватные и строго контролируемые исследования у беременных женщин отсутствуют. Применение натрия тиосульфата во время беременности возможно, если потенциальная польза для матери превышает потенциальный риск для плода. В проведенных эпидемиологических исследованиях не зарегистрировано врожденных аномалий у детей, рожденных от матерей, принимавших натрия тиосульфат во время беременности.\u003Cbr\u003EНеизвестно, проникает ли натрия тиосульфат в грудное молоко. Поскольку натрия тиосульфат вводят только при жизнеугрожающих состояниях, кормление грудью не является противопоказанием к его применению. В связи с тем, что многие препараты проникают в грудное молоко, следует соблюдать осторожность при применении натрия тиосульфата у кормящих женщин. Отсутствуют какие-либо данные по времени безопасного возобновления грудного вскармливания после введения натрия тиосульфата."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при управлении автомобилем и занятии потенциально опасными видами деятельности, требующими концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"При отравлении цианидами рекомендуется одновременное назначение натрия нитрита, при этом натрия тиосульфат вводится после натрия нитрита.\u003Cbr\u003EПри интоксикации цианидами следует избегать промедления при введении антидота (возможен быстрый летальный исход). Необходимо тщательно наблюдать за пациентом в течение 24-48 ч ввиду возможного возврата симптомов отравления цианидами. В случае возобновления симптомов введение натрия тиосульфата следует повторить в половинной дозе.\u003Cbr\u003EВ период лечения необходимо контролировать показатель гемоглобина и гематокрита.\u003Cbr\u003EПри наличии метгемоглобинемии измерения насыщения кислородом с использованием стандартных методик пульсоксиметрии и расчетных значений насыщения кислородом на основе измеренного РО2 ненадежны.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EПочечная недостаточность (замедленное выведение образующихся соединений), пожилой возраст (вследствие возможного нарушения функции почек), детский возраст до 18 лет (клинические исследования по оценке безопасности и эффективности натрия тиосульфата в педиатрической популяции отсутствуют, однако имеются сообщения в медицинской литературе о применении натрия тиосульфата в сочетании с натрия нитритом у педиатрических пациентов при отравлении цианидами, в связи с чем рекомендации по дозированию для педиатрических пациентов основаны на теоретических расчетах потенциального детоксикационного действия антидота, путем экстраполяции данных из экспериментов на животных, а также небольшого количества историй болезни)."},{"name":"Взаимодействие","value":"Категорически нельзя допускать контакта натрия тиосульфата с нитратами, перманганатом калия.\u003Cbr\u003EХимически несовместим с гидроксикобаламином, ввиду чего, их нельзя вводить через одно и то же устройство для внутривенного введения.\u003Cbr\u003EНе сообщалось о химической несовместимости натрия тиосульфата и натрия нитрита, вводимых последовательно через одну и ту же линию для внутривенного введения.\u003Cbr\u003EИсследования взаимодействия натрия тиосульфата с другими лекарственными средствами не проводились."},{"name":"Регистрационный номер","value":"ЛП-004638"},{"name":"Дата государственной регистрации","value":"17.01.2018"},{"name":"Владелец регистрационного удостоверения","value":"Дальхимфарм"},{"name":"Изготовитель","value":"Дальхимфарм"},{"name":"Фасовщик","value":"Дальхимфарм"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Натрия тиосульфат"},{"name":"Срок годности","value":"48 мес."}]}],"transitionId":"tr_6"}}}}
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Инструкция

Показания к применению

В качестве антидота при отравлении цианидами.

Противопоказания

Гиперчувствительность к натрия тиосульфату.

Способ применения и дозы

Внутривенно медленно. Лечение следует начинать как можно раньше после установления диагноза.
Взрослым вводят в разовой дозе 50 мл раствора, детям из расчета 250 мг/кг массы тела.
В случае если симптомы отравления цианидами вновь возникают, необходимо повторить введение препарата в дозе, составляющей 50% от первоначальной.
Во время введения необходимо контролировать артериальное давление: в случае выраженного снижения артериального давления, необходимо уменьшить скорость введения.
Полная инструкция
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Натрия тиосульфат р-р для в/в введ. амп.
Натрия тиосульфат р-р для в/в введ. амп., 300 мг/мл, 10 мл, 10 шт.
4.9
(11)
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Инструкция

93 ₽

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4.9
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У продавца:11 оценок·3 отзыва
У всех продавцов:54 оценки·14 отзывов
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user avatar
8 месяцев назад • Юлия Б. • Куплен на Маркете
Достоинства: Идеально для тех,кто борется с обострением псориаза
Недостатки: Пить можно,но не так эффективно
Комментарий: Хватает пяти внутривенных инъекций,чтобы снять сезонное обострение псориаза
user avatar
3 недели назад • Ирина Анисимова • Куплен на Маркете
Достоинства: Не очень приятный раствор на вкус, но ничего не поделаешь. Хотя особого эффекта я не почувствовала
user avatar
8 месяцев назад • Елена Уржунцева • Куплен на Маркете
Достоинства: удобный выбор аптеки,быстрая обработка заказа
Недостатки: нет
Комментарий: соответствует рецептуре
Посмотреть все отзывы на Маркете
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