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Описание

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Орлистат-акрихин капс., 120 мг, 84 шт.

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4.3
(6)
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Коротко о товаре

Артикул Маркета
4403452434
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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\u003Cbr/\u003E-синдром хронической мальабсорбции; \u003Cbr/\u003E-холестаз; \u003Cbr/\u003E-беременность и период грудного вскармливания; \u003Cbr/\u003E-детский возраст до 12 лет."},{"name":"Состав","value":"На 1 капсулу: \u003Cbr/\u003EДействующее вещество: орлистат - 120,00 мг; \u003Cbr/\u003EВспомогательные вещества: целлюлоза микрокристаллическая, карбоксиметилкрахмал натрия, кремния диоксид коллоидный, натрия лаурилсульфат. \u003Cbr/\u003EОболочка капсулы: твердая желатиновая капсула №1: желатин, титана диоксид (Е171), индигокармин (Е132)."},{"name":"Действующее вещество","value":"Орлистат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28710734"]}}},{"name":"Способ применения и дозы","value":"Внутрь, запивая водой, с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды). \u003Cbr/\u003EДлительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м2) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м2), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой: \u003Cbr/\u003Eу взрослых и детей старше 12 лет рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки. \u003Cbr/\u003EВ комбинации с гипогликемическими препаратами (метформин производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением: \u003Cbr/\u003Eу взрослых рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки. \u003Cbr/\u003EЕсли прием пищи пропускают или пища не содержит жира, то прием препарата Орлистат- Акрихин также можно пропустить. \u003Cbr/\u003EПрепарат следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема. \u003Cbr/\u003EУвеличение дозы орлистата свыше рекомендованной (120 мг 3 раза в сутки) не приводит к усилению его терапевтического эффекта. \u003Cbr/\u003EЭффективность и безопасность препарата Орлистат-Акрихин у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого и детского возраста (младше 12 лет не исследовались). \u003Cbr/\u003EУ пожилых пациентов, пациентов с нарушениями функции печени и почек коррекции дозы не требуется."},{"name":"Побочные действия","value":"Для описания частоты побочных реакции используются следующие категории: очень часто (≥ 1/10), часто (≥ 1/100, \u003C 1/10), нечасто (≥ 1/1 000, \u003C 1/100), редко (≥ 1/10 000, \u003C 1/1 000) и очень редко (\u003C1/10 000), включая отдельные случаи. \u003Cbr/\u003EПобочные реакции на орлистат возникали главным образом со стороны желудочно-кишечного тракта и были обусловлены фармакологическим действием препарата, препятствующего всасыванию жиров пищи. Частота развития нежелательных явлений уменьшалась при длительном использовании орлистата. \u003Cbr/\u003EУказанные ниже нежелательные явления возникали с частотой \u003E2% и инцидентностью ≥1% по сравнению с плацебо. \u003Cbr/\u003EИнфекционные и паразитарные заболевания: очень часто - грипп. \u003Cbr/\u003EНарушения со стороны обмена веществ и питания: очень часто - гипогликемия. \u003Cbr/\u003EНарушения психики: часто - тревога. \u003Cbr/\u003EНарушения со стороны нервной системы: очень часто - головная боль. \u003Cbr/\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: очень часто - инфекции верхних дыхательных путей; часто - инфекции нижних дыхательных путей. \u003Cbr/\u003EНарушения со стороны желудочно-кишечного тракта: очень часто - боли или дискомфорт в животе, маслянистые выделения из прямой кишки, выделение газов с некоторым количеством отделяемого, императивные позывы на дефекацию, стеаторея, метеоризм, жидкий стул, учащение дефекации; часто - боли или дискомфорт в прямой кишке, «мягкий» стул, недержание кала, поражение зубов, поражение десен, вздутие живота. \u003Cbr/\u003EНарушения со стороны почек и мочевыводящих путей: часто - инфекции мочевыводящих путей. \u003Cbr/\u003EНарушения со стороны половых органов и молочной железы: часто - нерегулярные менструации. \u003Cbr/\u003EОбщие расстройства и нарушения в месте введения: часто - слабость. \u003Cbr/\u003EУ пациентов с сахарным диабетом 2 типа характер и частота нежелательных явлений были сопоставимы с таковыми у лиц без сахарного диабета с избыточной массой тела и ожирением. \u003Cbr/\u003EЕдинственными новыми побочными явлениями у пациентов с ожирением и сахарным диабетом 2 типа гипогликемические состояния (очень часто) и вздутие живота (часто), возникавшие с частотой \u003E2% и инцидентностью ≥1% по сравнению с плацебо. \u003Cbr/\u003EЧастота нарушений со стороны желудочно-кишечного тракта увеличивается при повышении содержания жира в питании. Пациентов следует информировать о возможности возникновения побочных реакций со стороны желудочно-кишечного тракта и обучить, как устранять их путем лучшего соблюдения диеты, особенно в отношении количества содержащегося в ней жира. Применение диеты с низким содержанием жира уменьшает вероятность побочных действий со стороны желудочно-кишечного тракта и тем самым помогает пациентам контролировать и регулировать потребление жиров. \u003Cbr/\u003EКак правило, указанные побочные реакции являются слабо выраженными и транзиторными. Они возникали на ранних этапах лечения (в первые 3 месяца), причем, у большинства пациентов было не более одного эпизода таких реакций. \u003Cbr/\u003EВ 4-х летнем клиническом исследовании общий профиль безопасности не отличался от такового, полученного в 1- и 2-летних исследованиях. При этом общая частота возникновения нежелательных явлений со стороны желудочно-кишечного тракта ежегодно уменьшалась на протяжении 4-х летнего периода приема препарата. \u003Cbr/\u003EПостмаркетинговое наблюдение\u003Cbr/\u003EПеречисленные ниже нежелательные явления выявлены при спонтанных пострегистрационных сообщениях, частота развития неизвестна. \u003Cbr/\u003EНарушения со стороны иммунной системы: реакции гиперчувствительности, главными клиническими симптомами которых были зуд, сыпь, крапивница, ангионевротический отек, бронхоспазм и анафилаксия. \u003Cbr/\u003EНарушения со стороны желудочно-кишечного тракта: ректальное кровотечение, дивертикулит, панкреатит. \u003Cbr/\u003EНарушения со стороны печени и желчевыводящих путей: холелитиаз, отдельные, возможно серьезные, случаи поражения печени, приводящие к ее трансплантации или летальному исходу. \u003Cbr/\u003EНарушения со стороны кожи и подкожных тканей: буллезная сыпь. \u003Cbr/\u003EНарушения со стороны почек и мочевыводящих путей: оксалатная нефропатия, которая иногда может приводить к развитию почечной недостаточности. \u003Cbr/\u003EЛабораторные и инструментальные данные: повышение активности «печеночных» трансаминаз и щелочной фосфатазы, снижение концентрации протромбина, увеличение значений международного нормализованного отношения (МНО) и случаи несбалансированной терапии антикоагулянтами, что приводило к изменению гемостатических параметров. \u003Cbr/\u003EЗарегистрированы случаи развития гипероксалурии."},{"name":"Фармакологическое действие","value":"Орлистат - специфический ингибитор желудочно-кишечных липаз длительного действия. Действует в просвете желудка и тонкого кишечника, образуя ковалентную связь с активным сериновым участком желудочной и панкреатической липаз. Инактивированный фермент не способен расщеплять жиры пищи, поступающие в виде триглицеридов, до абсорбируемых свободных жирных кислот и моноглицеридов. Нерасщепленные триглицериды не всасываются, в связи с чем уменьшается поступление калорий в организм, что приводит к уменьшению массы тела. Терапевтическое действие препарата осуществляется без всасывания в системный кровоток. Увеличивает концентрацию жира в каловых массах через 24-48 ч после приема. Обеспечивает эффективный контроль массы тела, уменьшение депо жира. \u003Cbr/\u003EЭффективность\u003Cbr/\u003EПациенты с ожирением\u003Cbr/\u003EВ клинических исследованиях у пациентов, принимающих орлистат, наблюдалась большая потеря массы тела по сравнению с пациентами, находящимися на диетотерапии. Снижение массы тела начиналось уже в течение первых 2-х недель после начала лечения и продолжалось от 6 до 12 месяцев даже у пациентов с отрицательным ответом на диетотерапию. На протяжении 2-х лет наблюдалось статистически значимое улучшение профиля метаболических факторов риска, сопутствующих ожирению. Кроме того, по сравнению с приемом плацебо отмечалось значительное уменьшение количества жира в организме. \u003Cbr/\u003EОрлистат эффективен в отношении предотвращения повторной прибавки массы тела. Повторный набор массы тела, не более 25% от потерянного, наблюдался примерно у половины пациентов, а у половины из этих пациентов повторного набора массы тела не наблюдалось или даже отмечалось дальнейшее его снижение. \u003Cbr/\u003EПациенты с ожирением и сахарным диабетом второго типа\u003Cbr/\u003EВ клинических исследованиях длительностью от 6 месяцев до 1 года у пациентов с избыточной массой тела или ожирением и сахарным диабетом 2 типа, принимающих орлистат, наблюдалась большая потеря массы тела по сравнению с пациентами, проходившими лечение только диетотерапией. Потеря массы тела происходила в основном за счет уменьшения количества жира в организме. Следует отметить, что до начала исследования, несмотря на прием гипогликемических средств, у пациентов часто отмечался недостаточный контроль гликемии. Однако при проведении терапии орлистатом наблюдалось статистически и клинически значимое улучшение контроля гликемии. Кроме того, на фоне терапии орлистатом наблюдалось снижение доз гипогликемических средств, концентрации инсулина, а также уменьшение инсулинорезистентности. \u003Cbr/\u003EУменьшение риска развития сахарного диабета 2 типа у пациентов с ожирением\u003Cbr/\u003EВ 4-хлетнем клиническом исследовании было показано, что орлистат значительно снижает риск развития сахарного диабета 2-го типа (примерно на 37% по сравнению с плацебо). Степень уменьшения риска была даже более значительной у пациентов с исходным нарушением толерантности к глюкозе (приблизительно на 45%). В группе терапии орлистатом отмечалась более значительная потеря массы тела по сравнению с группой плацебо. Поддержание массы тела на новом уровне наблюдалось в течение всего периода исследования. Более того, по сравнению с плацебо у пациентов, получавших терапию орлистатом, наблюдалось значительное улучшение профиля метаболических факторов риска. \u003Cbr/\u003EПубертатное ожирение\u003Cbr/\u003EВ клиническом исследовании длительностью 1 год у подростков с ожирением, при приеме орлистата наблюдалось уменьшение индекса массы тела по сравнению с группой плацебо, где отмечалось даже увеличение индекса массы тела. Кроме того, у пациентов группы орлистата отмечалось уменьшение жировой массы, а также окружности талии и бедер по сравнению с группой плацебо. Также у пациентов, получавших терапию орлистатом, отмечалось значительное снижение диастолического артериального давления по сравнению с группой плацебо."},{"name":"Фармакологическая группа","value":"ингибиторы липазы ЖКТ"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"В оригинальной упаковке для защиты от света, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Случаи передозировки не описаны. \u003Cbr/\u003EУ лиц с нормальной массой тела и ожирением прием однократных (800 мг) и многократных доз орлистата (до 400 мг орлистата 3 раза в день на протяжении 15 дней) не вызывал нежелательных явлений. Кроме того, у пациентов с ожирением прием орлистата в дозе 240 мг три раза в день на протяжении 6 месяцев не сопровождался увеличением частоты возникновения нежелательных реакций. \u003Cbr/\u003EВ случае значительной передозировки орлистата рекомендуется наблюдение пациента на протяжении 24 часов. По данным доклинических и клинических исследований, системные эффекты, связанные с липазингибирующими свойствами орлистата, должны быть быстро обратимыми."},{"name":"Применение при беременности и кормлении грудью","value":"Доклинические исследования не выявили тератогенного и эмбриотоксического эффекта орлистата. Однако, в связи с отсутствием клинических данных о применении у беременных, орлистат противопоказан при беременности. \u003Cbr/\u003EПоскольку неизвестно, проникает ли орлистат в грудное молоко, он противопоказан в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не выявлено какого-либо отрицательного влияния орлистата на способность управлять автотранспортными средствами и механизмами."},{"name":"Особые указания","value":"С осторожностью: сопутствующая терапия циклоспорином, варфарином или другими пероральными антикоагулянтами.\u003Cbr\u003E\nОрлистат применяется для длительного контроля массы тела (снижение массы тела, поддержание ее на соответствующем уровне и предотвращение повторного прибавления массы тела).\u003Cbr\u003E\nЗа счет снижения массы тела на фоне приема орлистата, возможно улучшение углеводного обмена у пациентов с сахарным диабетом 2 типа, что может позволить уменьшить дозу гипогликемических препаратов.\u003Cbr\u003E\nПациент должен находиться на сбалансированной умеренно низкокалорийной диете, содержащей не более 30% калорий в виде жиров. Рекомендуется, чтобы такая диета была богата фруктами и овощами. Суточное потребление жиров должно быть распределено между тремя основными приемами пищи. Диета с низким содержанием жиров уменьшает вероятность развития нежелательных явлений со стороны желудочно-кишечного тракта. При применении орлистата наблюдались случаи ректального кровотечения. При появлении тяжелых и/или стойких симптомов кровотечения необходимо провести дополнительное обследование.\u003Cbr\u003E\nЕсли через 12 недель терапии не произошло снижения массы тела, как минимум, на 5%, прием орлистата следует прекратить.\u003Cbr\u003E\nЛечение не должно продолжаться более 2 лет.\u003Cbr\u003E\nПри появлении таких симптомов, как слабость, утомляемость, повышение температуры тела, желтуха и потемнение мочи, необходимо проконсультироваться с врачом для исключения нарушения функции печени.\u003Cbr\u003E\nПрименение орлистата может сопровождаться гипероксалурией и оксалатной нефропатией, которая иногда приводит к почечной недостаточности. Повышенному риску подвергаются пациенты с сопутствующими хроническими заболеваниями почек и/или обезвоживанием.\u003Cbr\u003E\nОрлистат может снижать всасывание антиретровирусных препаратов для лечения ВИЧ и отрицательно сказываться на их эффективности."},{"name":"Взаимодействие","value":"При одновременном применении орлистата и циклоспорина возможно снижение концентрации циклоспорина в плазме крови, что может привести к снижению иммуносупрессивной эффективности циклоспорина. Таким образом, сопутствующее применение орлистата и циклоспорина не рекомендуется. Тем не менее, если такое сопутствующее применение является необходимым, рекомендуется проводить более частый контроль концентрации циклоспорина в плазме крови как при одновременном применении его с орлистатом, так и после прекращения применения орлистата. Концентрацию циклоспорина в плазме крови следует контролировать до ее стабилизации. При одновременном применении орлистата с амиодароном рекомендуется клиническое наблюдение и мониторинг ЭКГ, так как возможно снижение концентрации амиодарона в плазме крови. \u003Cbr/\u003EПри одновременном приеме орлистата и варфарина или других антикоагулянтов, может наблюдаться снижение концентрации протромбина и повышение МНО, что приводит к изменению гемостатических показателей. Необходимо мониторировать показатели МНО при сопутствующей терапии варфарином или другими пероральными антикоагулянтами. Орлистат может уменьшать абсорбцию жирорастворимых витаминов A, D, Е, К и бета-каротина. Если показан прием поливитаминов, то их следует принимать не ранее, чем через 2 часа после приема орлистата или перед сном. \u003Cbr/\u003EОрлистат может снижать всасывание противоэпилептических препаратов, что может привести к возникновению судорог. \u003Cbr/\u003EИмеются сообщения о нескольких случаях снижения эффективности антиретровирусных препаратов для лечения ВИЧ, антидепрессантов, нейролептиков (включая литий) и бензодиазепинов, которое совпадало с началом лечения орлистатом у пациентов с ранее достигнутым адекватным контролем соответствующего состояния. У таких пациентов лечение орлистатом следует начинать после тщательной оценки соотношения польза/риск. \u003Cbr/\u003EС учетом отсутствия исследований фармакокинетического взаимодействия, совместного назначения орлистата и акарбозы необходимо избегать. \u003Cbr/\u003EОрлистат способен опосредованно снижать эффективность пероральных контрацептивов, что в отдельных случаях может привести к незапланированной беременности. Рекомендуется применять дополнительный метод контрацепции также в случае развития тяжелой диареи. \u003Cbr/\u003EПри одновременном приеме с левотироксином натрия, в связи с уменьшением всасывания неорганического йода и/или левотироксина натрия, может развиться гипотиреоз и/или снижение контроля гипотиреоза. \u003Cbr/\u003EНе выявлено лекарственного взаимодействия с амитриптилином, аторвастатином, бигуанидами, дигоксином, фибратами, флуоксетином, лозартаном, фенитоином, фентермином, правастатином, нифедипином, сибутрамином и этанолом."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛП-001455"},{"name":"Дата государственной регистрации","value":"30.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"Polpharma","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:16002745"]}}},{"name":"Изготовитель","value":"Polpharma"},{"name":"Фасовщик","value":"Polpharma"},{"name":"Страна-производитель","value":"Польша"},{"name":"Название препарата","value":"Орлистат","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18014575"]}}},{"name":"Срок годности","value":"24 мес."}]}},"fullSpecsGrouped":{"3654122894848502957":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"пищеварительная система"},{"name":"Назначение","value":"избыточная масса тела, похудение"},{"name":"Показания к применению","value":"Длительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м2) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м2), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой. \u003Cbr/\u003EВ комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением."},{"name":"Противопоказания","value":"-повышенная чувствительность к орлистату или любому из вспомогательных веществ препарата; \u003Cbr/\u003E-синдром хронической мальабсорбции; \u003Cbr/\u003E-холестаз; \u003Cbr/\u003E-беременность и период грудного вскармливания; \u003Cbr/\u003E-детский возраст до 12 лет."},{"name":"Состав","value":"На 1 капсулу: \u003Cbr/\u003EДействующее вещество: орлистат - 120,00 мг; \u003Cbr/\u003EВспомогательные вещества: целлюлоза микрокристаллическая, карбоксиметилкрахмал натрия, кремния диоксид коллоидный, натрия лаурилсульфат. \u003Cbr/\u003EОболочка капсулы: твердая желатиновая капсула №1: желатин, титана диоксид (Е171), индигокармин (Е132)."},{"name":"Действующее вещество","value":"Орлистат"},{"name":"Способ применения и дозы","value":"Внутрь, запивая водой, с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды). \u003Cbr/\u003EДлительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м2) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м2), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой: \u003Cbr/\u003Eу взрослых и детей старше 12 лет рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки. \u003Cbr/\u003EВ комбинации с гипогликемическими препаратами (метформин производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением: \u003Cbr/\u003Eу взрослых рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки. \u003Cbr/\u003EЕсли прием пищи пропускают или пища не содержит жира, то прием препарата Орлистат- Акрихин также можно пропустить. \u003Cbr/\u003EПрепарат следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема. \u003Cbr/\u003EУвеличение дозы орлистата свыше рекомендованной (120 мг 3 раза в сутки) не приводит к усилению его терапевтического эффекта. \u003Cbr/\u003EЭффективность и безопасность препарата Орлистат-Акрихин у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого и детского возраста (младше 12 лет не исследовались). \u003Cbr/\u003EУ пожилых пациентов, пациентов с нарушениями функции печени и почек коррекции дозы не требуется."},{"name":"Побочные действия","value":"Для описания частоты побочных реакции используются следующие категории: очень часто (≥ 1/10), часто (≥ 1/100, \u003C 1/10), нечасто (≥ 1/1 000, \u003C 1/100), редко (≥ 1/10 000, \u003C 1/1 000) и очень редко (\u003C1/10 000), включая отдельные случаи. \u003Cbr/\u003EПобочные реакции на орлистат возникали главным образом со стороны желудочно-кишечного тракта и были обусловлены фармакологическим действием препарата, препятствующего всасыванию жиров пищи. Частота развития нежелательных явлений уменьшалась при длительном использовании орлистата. \u003Cbr/\u003EУказанные ниже нежелательные явления возникали с частотой \u003E2% и инцидентностью ≥1% по сравнению с плацебо. \u003Cbr/\u003EИнфекционные и паразитарные заболевания: очень часто - грипп. \u003Cbr/\u003EНарушения со стороны обмена веществ и питания: очень часто - гипогликемия. \u003Cbr/\u003EНарушения психики: часто - тревога. \u003Cbr/\u003EНарушения со стороны нервной системы: очень часто - головная боль. \u003Cbr/\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения: очень часто - инфекции верхних дыхательных путей; часто - инфекции нижних дыхательных путей. \u003Cbr/\u003EНарушения со стороны желудочно-кишечного тракта: очень часто - боли или дискомфорт в животе, маслянистые выделения из прямой кишки, выделение газов с некоторым количеством отделяемого, императивные позывы на дефекацию, стеаторея, метеоризм, жидкий стул, учащение дефекации; часто - боли или дискомфорт в прямой кишке, «мягкий» стул, недержание кала, поражение зубов, поражение десен, вздутие живота. \u003Cbr/\u003EНарушения со стороны почек и мочевыводящих путей: часто - инфекции мочевыводящих путей. \u003Cbr/\u003EНарушения со стороны половых органов и молочной железы: часто - нерегулярные менструации. \u003Cbr/\u003EОбщие расстройства и нарушения в месте введения: часто - слабость. \u003Cbr/\u003EУ пациентов с сахарным диабетом 2 типа характер и частота нежелательных явлений были сопоставимы с таковыми у лиц без сахарного диабета с избыточной массой тела и ожирением. \u003Cbr/\u003EЕдинственными новыми побочными явлениями у пациентов с ожирением и сахарным диабетом 2 типа гипогликемические состояния (очень часто) и вздутие живота (часто), возникавшие с частотой \u003E2% и инцидентностью ≥1% по сравнению с плацебо. \u003Cbr/\u003EЧастота нарушений со стороны желудочно-кишечного тракта увеличивается при повышении содержания жира в питании. Пациентов следует информировать о возможности возникновения побочных реакций со стороны желудочно-кишечного тракта и обучить, как устранять их путем лучшего соблюдения диеты, особенно в отношении количества содержащегося в ней жира. Применение диеты с низким содержанием жира уменьшает вероятность побочных действий со стороны желудочно-кишечного тракта и тем самым помогает пациентам контролировать и регулировать потребление жиров. \u003Cbr/\u003EКак правило, указанные побочные реакции являются слабо выраженными и транзиторными. Они возникали на ранних этапах лечения (в первые 3 месяца), причем, у большинства пациентов было не более одного эпизода таких реакций. \u003Cbr/\u003EВ 4-х летнем клиническом исследовании общий профиль безопасности не отличался от такового, полученного в 1- и 2-летних исследованиях. При этом общая частота возникновения нежелательных явлений со стороны желудочно-кишечного тракта ежегодно уменьшалась на протяжении 4-х летнего периода приема препарата. \u003Cbr/\u003EПостмаркетинговое наблюдение\u003Cbr/\u003EПеречисленные ниже нежелательные явления выявлены при спонтанных пострегистрационных сообщениях, частота развития неизвестна. \u003Cbr/\u003EНарушения со стороны иммунной системы: реакции гиперчувствительности, главными клиническими симптомами которых были зуд, сыпь, крапивница, ангионевротический отек, бронхоспазм и анафилаксия. \u003Cbr/\u003EНарушения со стороны желудочно-кишечного тракта: ректальное кровотечение, дивертикулит, панкреатит. \u003Cbr/\u003EНарушения со стороны печени и желчевыводящих путей: холелитиаз, отдельные, возможно серьезные, случаи поражения печени, приводящие к ее трансплантации или летальному исходу. \u003Cbr/\u003EНарушения со стороны кожи и подкожных тканей: буллезная сыпь. \u003Cbr/\u003EНарушения со стороны почек и мочевыводящих путей: оксалатная нефропатия, которая иногда может приводить к развитию почечной недостаточности. \u003Cbr/\u003EЛабораторные и инструментальные данные: повышение активности «печеночных» трансаминаз и щелочной фосфатазы, снижение концентрации протромбина, увеличение значений международного нормализованного отношения (МНО) и случаи несбалансированной терапии антикоагулянтами, что приводило к изменению гемостатических параметров. \u003Cbr/\u003EЗарегистрированы случаи развития гипероксалурии."},{"name":"Фармакологическое действие","value":"Орлистат - специфический ингибитор желудочно-кишечных липаз длительного действия. Действует в просвете желудка и тонкого кишечника, образуя ковалентную связь с активным сериновым участком желудочной и панкреатической липаз. Инактивированный фермент не способен расщеплять жиры пищи, поступающие в виде триглицеридов, до абсорбируемых свободных жирных кислот и моноглицеридов. Нерасщепленные триглицериды не всасываются, в связи с чем уменьшается поступление калорий в организм, что приводит к уменьшению массы тела. Терапевтическое действие препарата осуществляется без всасывания в системный кровоток. Увеличивает концентрацию жира в каловых массах через 24-48 ч после приема. Обеспечивает эффективный контроль массы тела, уменьшение депо жира. \u003Cbr/\u003EЭффективность\u003Cbr/\u003EПациенты с ожирением\u003Cbr/\u003EВ клинических исследованиях у пациентов, принимающих орлистат, наблюдалась большая потеря массы тела по сравнению с пациентами, находящимися на диетотерапии. Снижение массы тела начиналось уже в течение первых 2-х недель после начала лечения и продолжалось от 6 до 12 месяцев даже у пациентов с отрицательным ответом на диетотерапию. На протяжении 2-х лет наблюдалось статистически значимое улучшение профиля метаболических факторов риска, сопутствующих ожирению. Кроме того, по сравнению с приемом плацебо отмечалось значительное уменьшение количества жира в организме. \u003Cbr/\u003EОрлистат эффективен в отношении предотвращения повторной прибавки массы тела. Повторный набор массы тела, не более 25% от потерянного, наблюдался примерно у половины пациентов, а у половины из этих пациентов повторного набора массы тела не наблюдалось или даже отмечалось дальнейшее его снижение. \u003Cbr/\u003EПациенты с ожирением и сахарным диабетом второго типа\u003Cbr/\u003EВ клинических исследованиях длительностью от 6 месяцев до 1 года у пациентов с избыточной массой тела или ожирением и сахарным диабетом 2 типа, принимающих орлистат, наблюдалась большая потеря массы тела по сравнению с пациентами, проходившими лечение только диетотерапией. Потеря массы тела происходила в основном за счет уменьшения количества жира в организме. Следует отметить, что до начала исследования, несмотря на прием гипогликемических средств, у пациентов часто отмечался недостаточный контроль гликемии. Однако при проведении терапии орлистатом наблюдалось статистически и клинически значимое улучшение контроля гликемии. Кроме того, на фоне терапии орлистатом наблюдалось снижение доз гипогликемических средств, концентрации инсулина, а также уменьшение инсулинорезистентности. \u003Cbr/\u003EУменьшение риска развития сахарного диабета 2 типа у пациентов с ожирением\u003Cbr/\u003EВ 4-хлетнем клиническом исследовании было показано, что орлистат значительно снижает риск развития сахарного диабета 2-го типа (примерно на 37% по сравнению с плацебо). Степень уменьшения риска была даже более значительной у пациентов с исходным нарушением толерантности к глюкозе (приблизительно на 45%). В группе терапии орлистатом отмечалась более значительная потеря массы тела по сравнению с группой плацебо. Поддержание массы тела на новом уровне наблюдалось в течение всего периода исследования. Более того, по сравнению с плацебо у пациентов, получавших терапию орлистатом, наблюдалось значительное улучшение профиля метаболических факторов риска. \u003Cbr/\u003EПубертатное ожирение\u003Cbr/\u003EВ клиническом исследовании длительностью 1 год у подростков с ожирением, при приеме орлистата наблюдалось уменьшение индекса массы тела по сравнению с группой плацебо, где отмечалось даже увеличение индекса массы тела. Кроме того, у пациентов группы орлистата отмечалось уменьшение жировой массы, а также окружности талии и бедер по сравнению с группой плацебо. Также у пациентов, получавших терапию орлистатом, отмечалось значительное снижение диастолического артериального давления по сравнению с группой плацебо."},{"name":"Фармакологическая группа","value":"ингибиторы липазы ЖКТ"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В оригинальной упаковке для защиты от света, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Случаи передозировки не описаны. \u003Cbr/\u003EУ лиц с нормальной массой тела и ожирением прием однократных (800 мг) и многократных доз орлистата (до 400 мг орлистата 3 раза в день на протяжении 15 дней) не вызывал нежелательных явлений. Кроме того, у пациентов с ожирением прием орлистата в дозе 240 мг три раза в день на протяжении 6 месяцев не сопровождался увеличением частоты возникновения нежелательных реакций. \u003Cbr/\u003EВ случае значительной передозировки орлистата рекомендуется наблюдение пациента на протяжении 24 часов. По данным доклинических и клинических исследований, системные эффекты, связанные с липазингибирующими свойствами орлистата, должны быть быстро обратимыми."},{"name":"Применение при беременности и кормлении грудью","value":"Доклинические исследования не выявили тератогенного и эмбриотоксического эффекта орлистата. Однако, в связи с отсутствием клинических данных о применении у беременных, орлистат противопоказан при беременности. \u003Cbr/\u003EПоскольку неизвестно, проникает ли орлистат в грудное молоко, он противопоказан в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не выявлено какого-либо отрицательного влияния орлистата на способность управлять автотранспортными средствами и механизмами."},{"name":"Особые указания","value":"С осторожностью: сопутствующая терапия циклоспорином, варфарином или другими пероральными антикоагулянтами.\u003Cbr\u003E\nОрлистат применяется для длительного контроля массы тела (снижение массы тела, поддержание ее на соответствующем уровне и предотвращение повторного прибавления массы тела).\u003Cbr\u003E\nЗа счет снижения массы тела на фоне приема орлистата, возможно улучшение углеводного обмена у пациентов с сахарным диабетом 2 типа, что может позволить уменьшить дозу гипогликемических препаратов.\u003Cbr\u003E\nПациент должен находиться на сбалансированной умеренно низкокалорийной диете, содержащей не более 30% калорий в виде жиров. Рекомендуется, чтобы такая диета была богата фруктами и овощами. Суточное потребление жиров должно быть распределено между тремя основными приемами пищи. Диета с низким содержанием жиров уменьшает вероятность развития нежелательных явлений со стороны желудочно-кишечного тракта. При применении орлистата наблюдались случаи ректального кровотечения. При появлении тяжелых и/или стойких симптомов кровотечения необходимо провести дополнительное обследование.\u003Cbr\u003E\nЕсли через 12 недель терапии не произошло снижения массы тела, как минимум, на 5%, прием орлистата следует прекратить.\u003Cbr\u003E\nЛечение не должно продолжаться более 2 лет.\u003Cbr\u003E\nПри появлении таких симптомов, как слабость, утомляемость, повышение температуры тела, желтуха и потемнение мочи, необходимо проконсультироваться с врачом для исключения нарушения функции печени.\u003Cbr\u003E\nПрименение орлистата может сопровождаться гипероксалурией и оксалатной нефропатией, которая иногда приводит к почечной недостаточности. Повышенному риску подвергаются пациенты с сопутствующими хроническими заболеваниями почек и/или обезвоживанием.\u003Cbr\u003E\nОрлистат может снижать всасывание антиретровирусных препаратов для лечения ВИЧ и отрицательно сказываться на их эффективности."},{"name":"Взаимодействие","value":"При одновременном применении орлистата и циклоспорина возможно снижение концентрации циклоспорина в плазме крови, что может привести к снижению иммуносупрессивной эффективности циклоспорина. Таким образом, сопутствующее применение орлистата и циклоспорина не рекомендуется. Тем не менее, если такое сопутствующее применение является необходимым, рекомендуется проводить более частый контроль концентрации циклоспорина в плазме крови как при одновременном применении его с орлистатом, так и после прекращения применения орлистата. Концентрацию циклоспорина в плазме крови следует контролировать до ее стабилизации. При одновременном применении орлистата с амиодароном рекомендуется клиническое наблюдение и мониторинг ЭКГ, так как возможно снижение концентрации амиодарона в плазме крови. \u003Cbr/\u003EПри одновременном приеме орлистата и варфарина или других антикоагулянтов, может наблюдаться снижение концентрации протромбина и повышение МНО, что приводит к изменению гемостатических показателей. Необходимо мониторировать показатели МНО при сопутствующей терапии варфарином или другими пероральными антикоагулянтами. Орлистат может уменьшать абсорбцию жирорастворимых витаминов A, D, Е, К и бета-каротина. Если показан прием поливитаминов, то их следует принимать не ранее, чем через 2 часа после приема орлистата или перед сном. \u003Cbr/\u003EОрлистат может снижать всасывание противоэпилептических препаратов, что может привести к возникновению судорог. \u003Cbr/\u003EИмеются сообщения о нескольких случаях снижения эффективности антиретровирусных препаратов для лечения ВИЧ, антидепрессантов, нейролептиков (включая литий) и бензодиазепинов, которое совпадало с началом лечения орлистатом у пациентов с ранее достигнутым адекватным контролем соответствующего состояния. У таких пациентов лечение орлистатом следует начинать после тщательной оценки соотношения польза/риск. \u003Cbr/\u003EС учетом отсутствия исследований фармакокинетического взаимодействия, совместного назначения орлистата и акарбозы необходимо избегать. \u003Cbr/\u003EОрлистат способен опосредованно снижать эффективность пероральных контрацептивов, что в отдельных случаях может привести к незапланированной беременности. Рекомендуется применять дополнительный метод контрацепции также в случае развития тяжелой диареи. \u003Cbr/\u003EПри одновременном приеме с левотироксином натрия, в связи с уменьшением всасывания неорганического йода и/или левотироксина натрия, может развиться гипотиреоз и/или снижение контроля гипотиреоза. \u003Cbr/\u003EНе выявлено лекарственного взаимодействия с амитриптилином, аторвастатином, бигуанидами, дигоксином, фибратами, флуоксетином, лозартаном, фенитоином, фентермином, правастатином, нифедипином, сибутрамином и этанолом."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛП-001455"},{"name":"Дата государственной регистрации","value":"30.08.2019"},{"name":"Владелец регистрационного удостоверения","value":"Polpharma"},{"name":"Изготовитель","value":"Polpharma"},{"name":"Фасовщик","value":"Polpharma"},{"name":"Страна-производитель","value":"Польша"},{"name":"Название препарата","value":"Орлистат"},{"name":"Срок годности","value":"24 мес."}]}],"transitionId":"tr_14396837498400771095"}}}}
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    Цена с картой Яндекс Пэй 706 ₽ вместо 713
    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  • Гепатрин капс., 120 шт.
    –11 %
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    Гепатрин капс., 120 шт.

    Рейтинг товара: 4.8 из 5
    на основе 882 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 886 ₽ вместо 895
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  • Жиросжигатель таблетки для похудения, витамин С, пиколинат хрома, экстракт зеленого чая, DEM4R Свелтформ-Р, 500 мг, 60 капсул
    –30 %
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    Жиросжигатель таблетки для похудения, витамин С, пиколинат хрома, экстракт зеленого чая, DEM4R Свелтформ-Р, 500 мг, 60 капсул

    Рейтинг товара: 4.4 из 5
    на основе 33 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 450 ₽ вместо 2 500
    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  • Блокатор калорий Три фазы капс., 40 шт., 1 уп.
    –54 %
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    Блокатор калорий Три фазы капс., 40 шт., 1 уп.

    Рейтинг товара: 4 из 5
    на основе 6 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 467 ₽ вместо 508
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  • Редуксин Лайт Усиленная Формула капс., 0.65 г, 30 шт., 1 уп.
    –1 %
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    Редуксин Лайт Усиленная Формула капс., 0.65 г, 30 шт., 1 уп.

    Рейтинг товара: 3.7 из 5
    на основе 23 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 3 316 ₽ вместо 3 349
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  • Редуксин лайт капс., 30 шт.
    –35 %
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    Редуксин лайт капс., 30 шт.

    Рейтинг товара: 4 из 5
    на основе 6 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 142 ₽ вместо 2 164
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  • Тетроген День/Ночь капс., 150 г, 20 шт., нейтральный
    –1 %
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    Тетроген День/Ночь капс., 150 г, 20 шт., нейтральный

    Рейтинг товара: 2 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 480 ₽ вместо 2 505
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  • Пиколинат хрома капли, 50 мл
    –12 %
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    Пиколинат хрома капли, 50 мл

    Рейтинг товара: 4.9 из 5
    на основе 14 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 378 ₽ вместо 382
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  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
    –50 %
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 577 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 752 ₽ вместо 1 770
    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  • Целлюлоза микрокристаллическая МКЦ АНКИР-Б таб., 120 г, 100 шт., нейтральный, 1 уп.
    –1 %
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    Целлюлоза микрокристаллическая МКЦ АНКИР-Б таб., 120 г, 100 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.3 из 5
    на основе 28 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 273 ₽ вместо 276
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Инструкция

Показания к применению

Длительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м2) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м2), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой.
В комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением.

Противопоказания

-повышенная чувствительность к орлистату или любому из вспомогательных веществ препарата;
-синдром хронической мальабсорбции;
-холестаз;
-беременность и период грудного вскармливания;
-детский возраст до 12 лет.

Способ применения и дозы

Внутрь, запивая водой, с каждым основным приемом пищи (непосредственно до еды, во время еды или не позднее чем через 1 час после еды).
Длительная терапия пациентов с ожирением (индекс массы тела ≥30 кг/м2) или пациентов с избыточной массой тела (индекс массы тела ≥28 кг/м2), имеющих ассоциированные с ожирением факторы риска, в сочетании с умеренно гипокалорийной диетой:
у взрослых и детей старше 12 лет рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки.
В комбинации с гипогликемическими препаратами (метформин производные сульфонилмочевины и/или инсулин) и/или умеренно гипокалорийной диетой пациентам с сахарным диабетом 2 типа с избыточной массой тела или ожирением:
у взрослых рекомендованная доза орлистата составляет одну капсулу 120 мг 3 раза в сутки.
Если прием пищи пропускают или пища не содержит жира, то прием препарата Орлистат- Акрихин также можно пропустить.
Препарат следует принимать в сочетании со сбалансированной, умеренно гипокалорийной диетой, содержащей не более 30% калоража в виде жиров. Суточное потребление жиров, углеводов и белков необходимо распределять на три основные приема.
Увеличение дозы орлистата свыше рекомендованной (120 мг 3 раза в сутки) не приводит к усилению его терапевтического эффекта.
Эффективность и безопасность препарата Орлистат-Акрихин у пациентов с нарушением функции печени и/или почек, а также у пациентов пожилого и детского возраста (младше 12 лет не исследовались).
У пожилых пациентов, пациентов с нарушениями функции печени и почек коррекции дозы не требуется.
Полная инструкция
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Орлистат-акрихин капс.
Орлистат-акрихин капс., 120 мг, 84 шт.
4.3
(6)
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5 вопросов
Инструкция

3 224 ₽

Скидка: 11%
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Вместо:3 623 ₽
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4.3
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Рекомендуем

  • Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов
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    Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов

    Цена 194 ₽ вместо 224
  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_1/content/content/gallery":{"title":"Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQrs7fqPTa25YYEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCJ358s8GEP7T0WwY1buhBiDa2cEH","sign":"WukNsP6rMCWj6ZLvyw7PrP6DaLNZVV67hebDWOgclVk="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_1/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_1/content/content/toggleWishlist":{"skuId":"227830270","productId":1778171037,"offerId":"pQcXMJSrQ6Doa9yziMm5Vg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQrs7fqPTa25YYEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCJ358s8GEP7T0WwY1buhBiDa2cEH","sign":"WukNsP6rMCWj6ZLvyw7PrP6DaLNZVV67hebDWOgclVk="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_1/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Цена 706 ₽ вместо 1 039
  • Силденафил-СЗ таб. п/о плен., 25 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1430912451_2/content/content/toggleWishlist":{"skuId":"228067804","productId":1430912451,"offerId":"WnKjPe4purqkQu79aH9XeQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQrs7fqPTa25YYEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCMP7p6oFENyT4GwYrt7QByDu3MEH","sign":"Wjv0bASABXmCtRcFCgZpKlFgDA3Q8PzmyrnHbGHfFns="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1430912451_2/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Силденафил-СЗ таб. п/о плен., 25 мг, 20 шт.

    Цена 219 ₽
  • Блокатор калорий Три фазы капс., 40 шт., 1 уп.
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    Блокатор калорий Три фазы капс., 40 шт., 1 уп.

    Цена 467 ₽ вместо 1 016
  • Редуксин Лайт Усиленная Формула капс., 0.65 г, 30 шт., 1 уп.
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    Редуксин Лайт Усиленная Формула капс., 0.65 г, 30 шт., 1 уп.

    Цена 3 316 ₽ вместо 3 349
  • Редуксин лайт капс., 30 шт.
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    Редуксин лайт капс., 30 шт.

    Цена 2 142 ₽ вместо 3 313
  • Квасцы жженые пор. д/нар. прим., 50 г, 1 уп.
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    Квасцы жженые пор. д/нар. прим., 50 г, 1 уп.

    Цена 167 ₽ вместо 169
  • Тетроген День/Ночь капс., 150 г, 20 шт., нейтральный
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    Тетроген День/Ночь капс., 150 г, 20 шт., нейтральный

    Цена 2 480 ₽ вместо 2 505
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    Реклама
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  • Жиросжигатель таблетки для похудения, витамин С, пиколинат хрома, экстракт зеленого чая, DEM4R Свелтформ-Р, 500 мг, 60 капсул
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    Жиросжигатель таблетки для похудения, витамин С, пиколинат хрома, экстракт зеленого чая, DEM4R Свелтформ-Р, 500 мг, 60 капсул

    Цена 2 450 ₽ вместо 3 500
  • Пиколинат хрома капли, 50 мл
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    Пиколинат хрома капли, 50 мл

    Цена 378 ₽ вместо 428
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 1 752 ₽ вместо 3 500
  • Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.
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    Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.

    Цена 2 005 ₽ вместо 2 800
  • Гепатрин капс., 120 шт.
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    Гепатрин капс., 120 шт.

    Цена 886 ₽ вместо 1 000
  • Тадалафил-СЗ таб. п/о плен., 20 мг, 8 шт.
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    Тадалафил-СЗ таб. п/о плен., 20 мг, 8 шт.

    Цена 341 ₽
  • Жидкий пластырь Fixplast c пантенолом, 60 мл
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:963598113_15/content/content/toggleWishlist":{"skuId":"101326256070","productId":963598113,"offerId":"HjZaXJ5LXqECxLVP3APR5Q","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQrs7fqPTa25YYEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCKGuvcsDEMbvj7z5AhjLrP4HIKDDBQ==","sign":"aV+Qt5PLEwVcWfEIrEEDz8EzwT+p71OSaUK1gMbiCp8="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:963598113_15/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Жидкий пластырь Fixplast c пантенолом, 60 мл

    Цена 355 ₽ вместо 399
  • Фенибут таб., 250 мг, 10 шт.
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    Фенибут таб., 250 мг, 10 шт.

    Цена 92 ₽
  • Целлюлоза микрокристаллическая МКЦ АНКИР-Б таб., 120 г, 100 шт., нейтральный, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778170926_17/content/content/gallery":{"title":"Целлюлоза микрокристаллическая МКЦ АНКИР-Б таб., 120 г, 100 шт., нейтральный, 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/1215212/img_id586846282980247043.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1215212/img_id586846282980247043.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1215212/img_id586846282980247043.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1215212/img_id586846282980247043.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1215212/img_id586846282980247043.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1215212/img_id586846282980247043.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/2016828/img_id142569459651330871.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/2016828/img_id142569459651330871.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/2016828/img_id142569459651330871.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/2016828/img_id142569459651330871.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/2016828/img_id142569459651330871.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/2016828/img_id142569459651330871.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQrs7fqPTa25YYEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCK748s8GEPX93mwY1buhBiDa2cEH","sign":"34S5oGu3W+ODO1vtm6qujFLZHpiumEBiHs1dDpeU/SE="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778170926_17/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Целлюлоза микрокристаллическая МКЦ АНКИР-Б таб., 120 г, 100 шт., нейтральный, 1 уп.

    Цена 273 ₽ вместо 276
  • ЛимфоТранзит концентрат напитка фл., 100 мл
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_18/content/content/toggleWishlist":{"skuId":"663078029","productId":1780857920,"offerId":"vvDuYa1NcTP9g5mBuSRxdg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQrs7fqPTa25YYEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMD4ltEGEI2Jl7wCGNW7oQYg19zBBw==","sign":"apA+cIDFr1LzICuEoPkWn79RuY0MGXGM7O/t+sYeTco="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_18/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 361 ₽ вместо 365
  • Тербинафин крем, 1%, 15 г, 1 шт.
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    Тербинафин крем, 1%, 15 г, 1 шт.

    Цена 79 ₽ вместо 80
  • Салфетка с нашатырем для стимуляции дыхания 3х6, 20 шт
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    Салфетка с нашатырем для стимуляции дыхания 3х6, 20 шт

    Цена 199 ₽ вместо 250
  • Олиджим таб., 30 г, 100 шт.
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    Олиджим таб., 30 г, 100 шт.

    Цена 462 ₽ вместо 599
  • Кетоконазол шампунь лекарственный, 2%, 75 г, 75 мл
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    Кетоконазол шампунь лекарственный, 2%, 75 г, 75 мл

    Цена 296 ₽ вместо 299
  • Марля медицинская повышенной плотности, отрез 3 метра
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    Марля медицинская повышенной плотности, отрез 3 метра

    Цена 157 ₽ вместо 199
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