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Описание

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Овестин супп. ваг., 0.5 мг, 15 шт.

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Коротко о товаре

Артикул Маркета
3672108555
Тип препарата
Назначение
Действующее вещество
Форма выпуска
суппозитории вагинальные
Инструкция
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состояния, предшествующие тромбозу (в т.ч. транзиторные ишемические атаки, стенокардия) в настоящее время или в анамнезе;\u003Cbr\u003E- заболевание печени в острой стадии или заболевание печени в анамнезе, после которого показатели функции печени не вернулись к норме;\u003Cbr\u003E- установленная повышенная чувствительность к активному веществу или к любому из вспомогательных веществ препарата;\u003Cbr\u003E- порфирия.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EС осторожностью (под тщательным наблюдением врача) препарат Овестин следует применять, если присутствуют любые из нижеперечисленных заболеваний или состояний, или эти заболевания или состояния отмечались ранее и/или ухудшались во время предшествующих беременностей или проводимого ранее гормонального лечения (т.к. они могут рецидивировать или ухудшиться во время лечения препаратом Овестин):\u003Cbr\u003E- лейомиома (фибромы матки) или эндометриоз;\u003Cbr\u003E- факторы риска тромбоэмболий (см. раздел \"Особые указания\");\u003Cbr\u003E- факторы риска эстрогенозависимых опухолей, например, 1-ая степень наследственности для рака молочной железы;\u003Cbr\u003E- артериальная гипертензия;\u003Cbr\u003E- доброкачественные опухоли печени (например, аденома печени);\u003Cbr\u003E- сахарный диабет с диабетической ангиопатией или без нее;\u003Cbr\u003E- желчекаменная болезнь;\u003Cbr\u003E- желтуха (в т.ч. в анамнезе во время предшествующей беременности);\u003Cbr\u003E- печеночная недостаточность;\u003Cbr\u003E- мигрень или (тяжёлая) головная боль;\u003Cbr\u003E- системная красная волчанка;\u003Cbr\u003E- гиперплазия эндометрия в анамнезе (см. раздел \"Особые указания\");\u003Cbr\u003E- эпилепсия;\u003Cbr\u003E- бронхиальная астма;\u003Cbr\u003E- отосклероз;\u003Cbr\u003E- семейная гиперлипопротеинемия;\u003Cbr\u003E- панкреатит."},{"name":"Состав","value":"Активное вещество: эстриол 0,5 мг.\u003Cbr\u003EВспомогательные вещества: витепсол S58 2,4995 г."},{"name":"Действующее вещество","value":"Эстриол","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["27144131:28708433"]}}},{"name":"Способ применения и дозы","value":"Овестин суппозитории следует вводить во влагалище на ночь перед сном.\u003Cbr\u003E- При лечении атрофии слизистой оболочки нижних отделов мочеполового тракта:\u003Cbr\u003E1 суппозиторий в сутки в течение первых недель с последующим постепенным снижением дозы, основываясь на облегчении симптомов, до достижения поддерживающей дозы (т.е. 1 суппозиторий дважды в неделю).\u003Cbr\u003E- Пред- и послеоперационная терапия женщин в постменопаузальном периоде, при хирургических вмешательствах влагалищным доступом:\u003Cbr\u003E1 суппозиторий в сутки в течение 2 недель перед операцией; 1 суппозиторий дважды в неделю в течение 2 недель после операции.\u003Cbr\u003E- С диагностической целью при неясных результатах цитологического исследования шейки матки:\u003Cbr\u003E1 суппозиторий через день в течение недели перед взятием следующего мазка. Пропущенную дозу необходимо ввести в этот же день как только больная вспомнит об этом (доза не должна вводиться дважды в день). В дальнейшем аппликации проводят в соответствии с обычной схемой дозирования.\u003Cbr\u003EПри начале или при продолжении лечения постменопаузальных симптомов необходимо применять наименьшую эффективную дозу в течение наиболее короткого промежутка времени.\u003Cbr\u003EУ женщин, не получающих ЗГТ, или женщин, которые переводятся с непрерывного перорального приёма комбинированного препарата для ЗГТ, лечение препаратом Овестин можно начинать в любой день. Женщины, которые переходят с циклического режима приёма препаратов для ЗГТ, должны начинать лечение препаратом Овестин через одну неделю после отмены препаратов ЗГТ."},{"name":"Побочные действия","value":"Как и в случае применения любого другого препарата, который наносится на поверхности слизистых оболочек, суппозитории Овестин® могут иногда вызывать местное раздражение или зуд. Иногда может отмечаться чувствительность, напряжённость, болезненность, увеличение размеров молочных желез. Эти нежелательные реакции обычно бывают непродолжительными и проходящими, но в то же время могут свидетельствовать о применении слишком высокой дозы.\u003Cbr\u003EТакже встречаются: ациклические кровянистые выделения, кровотечения \"прорыва\", метроррагия.\u003Cbr\u003EСообщается о других нежелательных реакциях, возникших на фоне монотерапии эстрогенами или комбинированной терапии эстрогенами и прогестагенами.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003E- Желчекаменная болезнь.\u003Cbr\u003EДоброкачественные, злокачественные и неуточненные новообразования (включая кисты и полипы):\u003Cbr\u003E- Доброкачественные и злокачественные эстрогенозависимые неоплазии, в т.ч. рак эндометрия (дополнительную информацию см. в разделах \"Противопоказания\" и \"Особые указания\").\u003Cbr\u003EНарушения психики:\u003Cbr\u003E- Деменция при начале ЗГТ в непрерывном режиме после 65 лет (см. раздел \"Особые указания\").\u003Cbr\u003EНарушения со стороны половых органов и молочной железы:\u003Cbr\u003E- Повышение либидо.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003E- Хлоазма, мультиформная эритема, узловатая эритема, геморрагическая пурпура.\u003Cbr\u003EСуществуют данные о развитии риска рака молочной железы, рака яичников, риска венозной тромбоэмболии, риска ишемической болезни сердца, риска ишемического инсульта (подробная информация представлена в разделе \"Особые указания\")."},{"name":"Фармакологическое действие","value":"Препарат Овестин содержит эстриол - аналог естественного женского гормона. Он восполняет дефицит эстрогенов у женщин в постменопаузальном периоде и ослабляет симптомы постменопаузы. Наиболее эффективен эстрирол в лечении мочеполовых расстройств. В случае атрофии слизистой оболочки нижних отделов мочеполового тракта эстриол способствует нормализации эпителия мочеполового тракта и способствует восстановлению нормальной микрофлоры и физиологического pH во влагалище. В результате он повышает сопротивляемость эпителиальных клеток мочеполового тракта к инфекции и к воспалению, снижая такие жалобы, как болезненность при половом акте, сухость, зуд во влагалище, уменьшает вероятность возникновения вагинальных инфекций и инфекций мочевого тракта, способствует нормализации мочеиспускания, и предотвращает недержание мочи.\u003Cbr\u003EВ отличие от других эстрогенов, эстриол обладает коротким периодом действия, поскольку в ядрах клеток эндометрия он удерживается в течение короткого промежутка времени. Предполагается, что одноразовое введение суточной дозы не вызывает пролиферации эндометрия. Поэтому не требуется циклического введения прогестагена и не возникает кровотечений отмены. Кроме того, показано, что эстриол не увеличивает маммографической плотности."},{"name":"Фармакологическая группа","value":"эстроген"},{"name":"Форма выпуска","value":"суппозитории вагинальные"},{"name":"Способ применения/введения","value":"интравагинально, местный","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["35947170:36763743,36763736"]}}},{"name":"Пол","value":"для женщин","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["14805991:14805993"]}}},{"name":"Условия хранения","value":"При температуре 2-25 °С в сухом, защищённом от света и недоступном для детей месте."},{"name":"Передозировка","value":"Острая токсичность эстриола у животных очень низкая. Передозировка препаратом Овестин® при вагинальном введении маловероятна. Однако в случае попадания больших количеств в желудочно-кишечный тракт может развиться тошнота, рвота и прекращение кровотечений у женщин.\u003Cbr\u003EСпецифический антидот не известен. При необходимости следует проводить симптоматическое лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат Овестин противопоказан во время беременности. В случае возникновения беременности во время терапии препаратом Овестин, лечение необходимо немедленно отменить. Результаты большинства эпидемиологических исследований, проведённых к настоящему времени относительно непреднамеренного воздействия эстрогенов на плод, свидетельствуют об отсутствии тератогенных или фетотоксических эффектов.\u003Cbr\u003EПрепарат Овестин не рекомендован во время кормления грудью. Эстриол выводится с грудным молоком и может уменьшать образование молока."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияния препарата Овестин на концентрацию и внимание не отмечено."},{"name":"Особые указания","value":"- Для лечения климактерических симптомов ЗГТ необходимо начинать только в отношении симптомов, которые неблагоприятно влияют на качество жизни. Во всех случаях необходимо не менее одного раза в год проводить тщательную оценку риска и пользы лечения и ЗГТ следует продолжать только в течение времени, пока польза превышает риск.\u003Cbr\u003E- Существуют ограниченные доказательства развития риска ЗГТ при лечении преждевременной менопаузы. Ввиду низкого абсолютного риска у более молодых женщин соотношение польза-риск у них благоприятнее, чем у более пожилых.\u003Cbr\u003EМедицинское обследование/наблюдение\u003Cbr\u003E- Перед началом или возобновлением ЗГТ необходимо собрать подробный индивидуальный и семейный анамнез. Руководствуясь полученным анамнезом, противопоказаниями и предупреждениями по применению препарата, необходимо провести клиническое обследование, включая обследование органов малого таза и молочных желёз. Во время лечения рекомендуется проводить периодические медицинские осмотры, частота и характер которых индивидуальны. Женщины должны быть информированы о необходимости сообщения врачу об изменениях в молочных железах (см. ниже подраздел \"Рак молочной железы\"). Исследования, включая соответствующие методы визуализации, например маммографию, необходимо проводить в соответствии с принятыми в настоящее время стандартами обследования и в зависимости от каждого конкретного случая.\u003Cbr\u003EПричины для немедленной отмены терапии\u003Cbr\u003EТерапию следует прекратить в случае выявления противопоказания и при возникновении следующих состояний:\u003Cbr\u003E- Желтуха или ухудшение функции печени;\u003Cbr\u003E- Значительное повышение артериального давления;\u003Cbr\u003E- Возникновение головной боли по типу мигрени;\u003Cbr\u003E- Беременность.\u003Cbr\u003EГиперплазия эндометрия и карцинома\u003Cbr\u003E- Для предупреждения стимуляции эндометрия суточная доза препарата не должна превышать 1 суппозитория (0,5 мг эстриола). Не следует применять эту максимальную дозу в течение более 4 недель. Кроме того, в одном эпидемиологическом исследовании было выявлено, что длительный приём эстриола в низких дозах, применяемого перорально, но не интравагинально, может повышать риск рака эндометрия. Риск возрастает по мере увеличения продолжительности лечения и возвращается к исходным значениям через год после отмены препарата. В основном повышается риск малоинвазивных и высокодифференцированных опухолей. Вагинальные кровотечения во всех случаях требуют обследования. Пациентка должна быть информирована о необходимости связаться с лечащим врачом в случае начала вагинального кровотечения.\u003Cbr\u003EРак молочной железы\u003Cbr\u003E- Заместительная гормональная терапия может увеличивать маммографическую плотность. Это может усложнять радиологическое обнаружение рака молочной железы. Клинические исследования показали, что вероятность увеличения маммографической плотности ниже у женщин, получающих лечение эстриолом, чем у женщин, получающих лечение другими эстрогенами.\u003Cbr\u003E- Обобщённые доказательства свидетельствуют об увеличенном риске рака молочной железы у женщин, получающих комбинированную терапию эстрогенами и прогестагенами и, возможно, монотерапию эстрогенами.\u003Cbr\u003E- У женщин, получающих комбинированную терапию эстрогенами и прогестагенами более 5 лет, отмечено увеличение риска рака молочной железы в 2 раза.\u003Cbr\u003E- При монотерапии эстрогенами увеличение риска существенно ниже, чем при их сочетании с прогестагенами.\u003Cbr\u003E- Уровень риска зависит от длительности ЗГТ.\u003Cbr\u003E- Неизвестно, представляет ли препарат Овестин® такой же риск. В недавно проведённом популяционном исследовании случай-контроль с участием 3345 женщин с инвазивным раком молочной железы и 3454 женщин в контрольной группе показано, что применение эстриола, в отличие от других эстрогенов, не было связано с повышенным риском развития рака молочной железы. Поэтому важно, чтобы риск развития рака молочной железы был обсужден с пациенткой и соотнесен с известной пользой ЗГТ.\u003Cbr\u003EРак яичников\u003Cbr\u003E- Рак яичников развивается значительно реже, чем рак молочной железы. Длительная монотерапия эстрогенами (по крайней мере, 5-10 лет) была сопряжена с небольшим увеличением риска рака яичников. Результаты некоторых исследований свидетельствуют о том, что комбинированная ЗГТ может повышать риск рака яичников сходным образом либо незначительно. Неизвестно, отличается ли риск при длительном приёме низкоактивных эстрогенов (таких, как Овестин®) от такового при монотерапии другими эстрогенами.\u003Cbr\u003EВенозные тромбоэмболии\u003Cbr\u003E- ЗГТ связана с увеличением риска развития венозной тромбоэмболии (ВТЭ), т.е. тромбоза глубоких вен или эмболии легочной артерии, в 1,3-3 раза. Вероятность развития ВТЭ выше в течение первого года применения ЗГТ, чем в более поздние сроки. Неизвестно, имеет ли препарат Овестин® такой же риск.\u003Cbr\u003E- У пациенток с подтверждённой тромбофилией риск ВТЭ высокий, а ЗГТ может дополнительно его увеличивать. В связи с этим таким женщинам ЗГТ противопоказана (см. раздел \"Противопоказания\").\u003Cbr\u003E- Обычно признанными факторами риска ВТЭ является прием эстрогенов, пожилой возраст, обширные хирургические вмешательства, длительная иммобилизация, ожирение (ИМТ \u003E30 кг/м2), беременность/послеродовый период, системная красная волчанка и рак. Не существует единого мнения относительно возможной роли варикозного расширения вен в развитии ВТЭ. После любого хирургического вмешательства необходимо проводить профилактику ВТЭ. Если длительная иммобилизация связана с плановой операцией, необходимо временно отменить ЗГТ за 4-6 недель до операции. Лечение следует возобновить после того, как женщина начнёт ходить.\u003Cbr\u003E- В отношении женщин, которые уже получают лечение антикоагулянтами, требуется тщательное рассмотрение соотношения польза-риск ЗГТ.\u003Cbr\u003E- Если Овестин® назначен в качестве \"пред- и послеоперационного лечения...\", следует рассмотреть вопрос о профилактике тромбозов.\u003Cbr\u003E- При отсутствии ВТЭ в анамнезе, но при наличии тромбоза в молодом возрасте у ближайших родственников пациентки ей можно предложить провести скрининговое обследование, предварительно обсудив все его ограничения (скрининг позволяет выявить только ряд тромбофилических нарушений). При выявлении тромбофилического дефекта, не соответствующего заболеванию у родственников, либо при обнаружении \"тяжёлого\" дефекта (например, дефицита антитромбина, протеина S или протеина С, либо сочетания этих дефектов) ЗГТ противопоказана.\u003Cbr\u003E- Если после начала лечения препаратом Овестин® развивается ВТЭ, то лечение необходимо прекратить. Пациентки должны быть информированы о необходимости немедленного обращения к врачу, если они почувствуют возможные признаки тромбоэмболии (например, болезненный отёк ноги, внезапная боль в груди, одышка).\u003Cbr\u003EИшемическая болезнь сердца (ИБС)\u003Cbr\u003E- В рандомизированных контролируемых исследованиях не получено результатов, которые свидетельствовали бы о том, что комбинированная терапия эстрогенами и прогестагенами и монотерапия эстрогенами могут предупреждать развитие инфаркта миокарда у женщин с ИБС и без неё.\u003Cbr\u003EМонотерапия эстрогенами\u003Cbr\u003E- По данным рандомизированных контролируемых исследований у женщин с удаленной маткой риск ИБС при монотерапии эстрогенами не увеличивается.\u003Cbr\u003E- Риск ишемической болезни сердца несколько увеличивается при комбинированной ЗГТ эстрогенами и прогестагенами у пациенток старше 60 лет.\u003Cbr\u003EИшемический инсульт\u003Cbr\u003E- Комбинированная терапия эстрогенами и прогестагенами и монотерапия эстрогенами сопряжены с увеличением риска ишемического инсульта в 1,5 раза. Относительный риск с возрастом и со временем после наступления менопаузы не меняется. Однако исходный риск инсульта в большой степени зависит от возраста, и общий риск инсульта на фоне ЗГТ с возрастом увеличивается. Риск геморрагического инсульта при ЗГТ не увеличивается.\u003Cbr\u003EДругие состояния\u003Cbr\u003E- Эстрогены могут вызывать задержку жидкости, и поэтому пациентки с нарушением функции почек и сердечно-сосудистой недостаточностью должны находиться под тщательным контролем.\u003Cbr\u003E- Эстриол является слабым антагонистом гонадотропина и не оказывает других значимых влияний на эндокринную систему.\u003Cbr\u003E- Когнитивная функция на фоне ЗГТ не улучшается. Получено свидетельство о повышенном риске развития деменции у женщин, начавших применять комбинированную терапию или монотерапию в непрерывном режиме после 65 лет."},{"name":"Взаимодействие","value":"В клинической практике не отмечено взаимодействия между препаратом Овестин и другими лекарственными средствами.\u003Cbr\u003EМетаболизм эстрогенов может усиливаться при их применении в сочетании с соединениями, которые индуцируют ферменты, участвующие в метаболизме лекарственных средств, в особенности, ферменты цитохрома Р450, например, такие как противосудорожные средства (например, фенобарбитал, фенитоин, карбамазепин) и противомикробные средства (например, рифампицин, рифабутин, невирапин, эфавиренц). Ритонавир и нелфинавир проявляют индуцирующие свойства при применении в сочетании со стероидными гормонами.\u003Cbr\u003EРастительные препараты, содержащие зверобой (Hypericum Perforatum), могут индуцировать метаболизм эстрогенов.\u003Cbr\u003EПовышенный метаболизм эстрогенов может привести к снижению их клинического эффекта.\u003Cbr\u003EЭстриол усиливает действие гиполипидемических лекарственных средств; ослабляет эффекты мужских половых гормонов, антикоагулянтов, антидепрессантов, диуретических, гипотензивных, гипогликемических лекарственных средств.\u003Cbr\u003EЛекарственные средства для общей анестезии, наркотические анальгетики, анксиолитики, некоторые гипотензивные лекарственные средства, этанол снижают эффективность препарата.\u003Cbr\u003EФолиевая кислота и препараты щитовидной железы усиливают действия эстриола."},{"name":"Регистрационный номер","value":"П N013327/01"},{"name":"Дата государственной регистрации","value":"10.01.2017"},{"name":"Владелец регистрационного удостоверения","value":"Аспен Фарма Трейдинг Лимитед","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["34324371:35649313","7893318:36062970"]}}},{"name":"Страна бренда","value":"Ирландия"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Овестин","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["17796364:18031651"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"4378199729043304028":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"выделительная система, половая система"},{"name":"Назначение","value":"атрофический вульвовагинит, заместительная гормональная терапия при дефиците эстрогенов, эстрогенная недостаточность в постменопаузе"},{"name":"Показания к применению","value":"- Заместительная гормональная терапия (ЗГТ) для лечения атрофии слизистой оболочки нижних отделов мочеполового тракта, связанной с эстрогеновой недостаточностью у женщин в постменопаузе;\u003Cbr\u003E- пред- и послеоперационная терапия женщин в постменопаузальном периоде, при хирургических вмешательствах при влагалищном доступе;\u003Cbr\u003E- как вспомогательное средство диагностики при получении атрофической картины цервикального мазка."},{"name":"Противопоказания","value":"- Установленный, имеющийся в анамнезе или подозреваемый рак молочной железы;\u003Cbr\u003E- диагностированные эстрогенозависимые опухоли или подозрение на них (например, рак эндометрия);\u003Cbr\u003E- кровотечение из влагалища неясной этиологии;\u003Cbr\u003E- нелеченная гиперплазия эндометрия;\u003Cbr\u003E- наличие венозных тромбозов в настоящее время и в анамнезе (тромбоз глубоких вен, легочная тромбоэмболия);\u003Cbr\u003E- подтвержденные тромбофилии (например, дефицит протеина С, протеина S или антитромбина (см. раздел \"Особые указания\"));\u003Cbr\u003E- тромбозы (венозные и артериальные) и тромбоэмболии в настоящее время или в анамнезе (в т.ч. тромбоз глубоких вен, тромбоэмболия легочной артерии, инфаркт миокарда, инсульт), цереброваскулярные нарушения; состояния, предшествующие тромбозу (в т.ч. транзиторные ишемические атаки, стенокардия) в настоящее время или в анамнезе;\u003Cbr\u003E- заболевание печени в острой стадии или заболевание печени в анамнезе, после которого показатели функции печени не вернулись к норме;\u003Cbr\u003E- установленная повышенная чувствительность к активному веществу или к любому из вспомогательных веществ препарата;\u003Cbr\u003E- порфирия.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EС осторожностью (под тщательным наблюдением врача) препарат Овестин следует применять, если присутствуют любые из нижеперечисленных заболеваний или состояний, или эти заболевания или состояния отмечались ранее и/или ухудшались во время предшествующих беременностей или проводимого ранее гормонального лечения (т.к. они могут рецидивировать или ухудшиться во время лечения препаратом Овестин):\u003Cbr\u003E- лейомиома (фибромы матки) или эндометриоз;\u003Cbr\u003E- факторы риска тромбоэмболий (см. раздел \"Особые указания\");\u003Cbr\u003E- факторы риска эстрогенозависимых опухолей, например, 1-ая степень наследственности для рака молочной железы;\u003Cbr\u003E- артериальная гипертензия;\u003Cbr\u003E- доброкачественные опухоли печени (например, аденома печени);\u003Cbr\u003E- сахарный диабет с диабетической ангиопатией или без нее;\u003Cbr\u003E- желчекаменная болезнь;\u003Cbr\u003E- желтуха (в т.ч. в анамнезе во время предшествующей беременности);\u003Cbr\u003E- печеночная недостаточность;\u003Cbr\u003E- мигрень или (тяжёлая) головная боль;\u003Cbr\u003E- системная красная волчанка;\u003Cbr\u003E- гиперплазия эндометрия в анамнезе (см. раздел \"Особые указания\");\u003Cbr\u003E- эпилепсия;\u003Cbr\u003E- бронхиальная астма;\u003Cbr\u003E- отосклероз;\u003Cbr\u003E- семейная гиперлипопротеинемия;\u003Cbr\u003E- панкреатит."},{"name":"Состав","value":"Активное вещество: эстриол 0,5 мг.\u003Cbr\u003EВспомогательные вещества: витепсол S58 2,4995 г."},{"name":"Действующее вещество","value":"Эстриол"},{"name":"Способ применения и дозы","value":"Овестин суппозитории следует вводить во влагалище на ночь перед сном.\u003Cbr\u003E- При лечении атрофии слизистой оболочки нижних отделов мочеполового тракта:\u003Cbr\u003E1 суппозиторий в сутки в течение первых недель с последующим постепенным снижением дозы, основываясь на облегчении симптомов, до достижения поддерживающей дозы (т.е. 1 суппозиторий дважды в неделю).\u003Cbr\u003E- Пред- и послеоперационная терапия женщин в постменопаузальном периоде, при хирургических вмешательствах влагалищным доступом:\u003Cbr\u003E1 суппозиторий в сутки в течение 2 недель перед операцией; 1 суппозиторий дважды в неделю в течение 2 недель после операции.\u003Cbr\u003E- С диагностической целью при неясных результатах цитологического исследования шейки матки:\u003Cbr\u003E1 суппозиторий через день в течение недели перед взятием следующего мазка. Пропущенную дозу необходимо ввести в этот же день как только больная вспомнит об этом (доза не должна вводиться дважды в день). В дальнейшем аппликации проводят в соответствии с обычной схемой дозирования.\u003Cbr\u003EПри начале или при продолжении лечения постменопаузальных симптомов необходимо применять наименьшую эффективную дозу в течение наиболее короткого промежутка времени.\u003Cbr\u003EУ женщин, не получающих ЗГТ, или женщин, которые переводятся с непрерывного перорального приёма комбинированного препарата для ЗГТ, лечение препаратом Овестин можно начинать в любой день. Женщины, которые переходят с циклического режима приёма препаратов для ЗГТ, должны начинать лечение препаратом Овестин через одну неделю после отмены препаратов ЗГТ."},{"name":"Побочные действия","value":"Как и в случае применения любого другого препарата, который наносится на поверхности слизистых оболочек, суппозитории Овестин® могут иногда вызывать местное раздражение или зуд. Иногда может отмечаться чувствительность, напряжённость, болезненность, увеличение размеров молочных желез. Эти нежелательные реакции обычно бывают непродолжительными и проходящими, но в то же время могут свидетельствовать о применении слишком высокой дозы.\u003Cbr\u003EТакже встречаются: ациклические кровянистые выделения, кровотечения \"прорыва\", метроррагия.\u003Cbr\u003EСообщается о других нежелательных реакциях, возникших на фоне монотерапии эстрогенами или комбинированной терапии эстрогенами и прогестагенами.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003E- Желчекаменная болезнь.\u003Cbr\u003EДоброкачественные, злокачественные и неуточненные новообразования (включая кисты и полипы):\u003Cbr\u003E- Доброкачественные и злокачественные эстрогенозависимые неоплазии, в т.ч. рак эндометрия (дополнительную информацию см. в разделах \"Противопоказания\" и \"Особые указания\").\u003Cbr\u003EНарушения психики:\u003Cbr\u003E- Деменция при начале ЗГТ в непрерывном режиме после 65 лет (см. раздел \"Особые указания\").\u003Cbr\u003EНарушения со стороны половых органов и молочной железы:\u003Cbr\u003E- Повышение либидо.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003E- Хлоазма, мультиформная эритема, узловатая эритема, геморрагическая пурпура.\u003Cbr\u003EСуществуют данные о развитии риска рака молочной железы, рака яичников, риска венозной тромбоэмболии, риска ишемической болезни сердца, риска ишемического инсульта (подробная информация представлена в разделе \"Особые указания\")."},{"name":"Фармакологическое действие","value":"Препарат Овестин содержит эстриол - аналог естественного женского гормона. Он восполняет дефицит эстрогенов у женщин в постменопаузальном периоде и ослабляет симптомы постменопаузы. Наиболее эффективен эстрирол в лечении мочеполовых расстройств. В случае атрофии слизистой оболочки нижних отделов мочеполового тракта эстриол способствует нормализации эпителия мочеполового тракта и способствует восстановлению нормальной микрофлоры и физиологического pH во влагалище. В результате он повышает сопротивляемость эпителиальных клеток мочеполового тракта к инфекции и к воспалению, снижая такие жалобы, как болезненность при половом акте, сухость, зуд во влагалище, уменьшает вероятность возникновения вагинальных инфекций и инфекций мочевого тракта, способствует нормализации мочеиспускания, и предотвращает недержание мочи.\u003Cbr\u003EВ отличие от других эстрогенов, эстриол обладает коротким периодом действия, поскольку в ядрах клеток эндометрия он удерживается в течение короткого промежутка времени. Предполагается, что одноразовое введение суточной дозы не вызывает пролиферации эндометрия. Поэтому не требуется циклического введения прогестагена и не возникает кровотечений отмены. Кроме того, показано, что эстриол не увеличивает маммографической плотности."},{"name":"Фармакологическая группа","value":"эстроген"},{"name":"Форма выпуска","value":"суппозитории вагинальные"},{"name":"Способ применения/введения","value":"интравагинально, местный"},{"name":"Пол","value":"для женщин"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре 2-25 °С в сухом, защищённом от света и недоступном для детей месте."},{"name":"Передозировка","value":"Острая токсичность эстриола у животных очень низкая. Передозировка препаратом Овестин® при вагинальном введении маловероятна. Однако в случае попадания больших количеств в желудочно-кишечный тракт может развиться тошнота, рвота и прекращение кровотечений у женщин.\u003Cbr\u003EСпецифический антидот не известен. При необходимости следует проводить симптоматическое лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат Овестин противопоказан во время беременности. В случае возникновения беременности во время терапии препаратом Овестин, лечение необходимо немедленно отменить. Результаты большинства эпидемиологических исследований, проведённых к настоящему времени относительно непреднамеренного воздействия эстрогенов на плод, свидетельствуют об отсутствии тератогенных или фетотоксических эффектов.\u003Cbr\u003EПрепарат Овестин не рекомендован во время кормления грудью. Эстриол выводится с грудным молоком и может уменьшать образование молока."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияния препарата Овестин на концентрацию и внимание не отмечено."},{"name":"Особые указания","value":"- Для лечения климактерических симптомов ЗГТ необходимо начинать только в отношении симптомов, которые неблагоприятно влияют на качество жизни. Во всех случаях необходимо не менее одного раза в год проводить тщательную оценку риска и пользы лечения и ЗГТ следует продолжать только в течение времени, пока польза превышает риск.\u003Cbr\u003E- Существуют ограниченные доказательства развития риска ЗГТ при лечении преждевременной менопаузы. Ввиду низкого абсолютного риска у более молодых женщин соотношение польза-риск у них благоприятнее, чем у более пожилых.\u003Cbr\u003EМедицинское обследование/наблюдение\u003Cbr\u003E- Перед началом или возобновлением ЗГТ необходимо собрать подробный индивидуальный и семейный анамнез. Руководствуясь полученным анамнезом, противопоказаниями и предупреждениями по применению препарата, необходимо провести клиническое обследование, включая обследование органов малого таза и молочных желёз. Во время лечения рекомендуется проводить периодические медицинские осмотры, частота и характер которых индивидуальны. Женщины должны быть информированы о необходимости сообщения врачу об изменениях в молочных железах (см. ниже подраздел \"Рак молочной железы\"). Исследования, включая соответствующие методы визуализации, например маммографию, необходимо проводить в соответствии с принятыми в настоящее время стандартами обследования и в зависимости от каждого конкретного случая.\u003Cbr\u003EПричины для немедленной отмены терапии\u003Cbr\u003EТерапию следует прекратить в случае выявления противопоказания и при возникновении следующих состояний:\u003Cbr\u003E- Желтуха или ухудшение функции печени;\u003Cbr\u003E- Значительное повышение артериального давления;\u003Cbr\u003E- Возникновение головной боли по типу мигрени;\u003Cbr\u003E- Беременность.\u003Cbr\u003EГиперплазия эндометрия и карцинома\u003Cbr\u003E- Для предупреждения стимуляции эндометрия суточная доза препарата не должна превышать 1 суппозитория (0,5 мг эстриола). Не следует применять эту максимальную дозу в течение более 4 недель. Кроме того, в одном эпидемиологическом исследовании было выявлено, что длительный приём эстриола в низких дозах, применяемого перорально, но не интравагинально, может повышать риск рака эндометрия. Риск возрастает по мере увеличения продолжительности лечения и возвращается к исходным значениям через год после отмены препарата. В основном повышается риск малоинвазивных и высокодифференцированных опухолей. Вагинальные кровотечения во всех случаях требуют обследования. Пациентка должна быть информирована о необходимости связаться с лечащим врачом в случае начала вагинального кровотечения.\u003Cbr\u003EРак молочной железы\u003Cbr\u003E- Заместительная гормональная терапия может увеличивать маммографическую плотность. Это может усложнять радиологическое обнаружение рака молочной железы. Клинические исследования показали, что вероятность увеличения маммографической плотности ниже у женщин, получающих лечение эстриолом, чем у женщин, получающих лечение другими эстрогенами.\u003Cbr\u003E- Обобщённые доказательства свидетельствуют об увеличенном риске рака молочной железы у женщин, получающих комбинированную терапию эстрогенами и прогестагенами и, возможно, монотерапию эстрогенами.\u003Cbr\u003E- У женщин, получающих комбинированную терапию эстрогенами и прогестагенами более 5 лет, отмечено увеличение риска рака молочной железы в 2 раза.\u003Cbr\u003E- При монотерапии эстрогенами увеличение риска существенно ниже, чем при их сочетании с прогестагенами.\u003Cbr\u003E- Уровень риска зависит от длительности ЗГТ.\u003Cbr\u003E- Неизвестно, представляет ли препарат Овестин® такой же риск. В недавно проведённом популяционном исследовании случай-контроль с участием 3345 женщин с инвазивным раком молочной железы и 3454 женщин в контрольной группе показано, что применение эстриола, в отличие от других эстрогенов, не было связано с повышенным риском развития рака молочной железы. Поэтому важно, чтобы риск развития рака молочной железы был обсужден с пациенткой и соотнесен с известной пользой ЗГТ.\u003Cbr\u003EРак яичников\u003Cbr\u003E- Рак яичников развивается значительно реже, чем рак молочной железы. Длительная монотерапия эстрогенами (по крайней мере, 5-10 лет) была сопряжена с небольшим увеличением риска рака яичников. Результаты некоторых исследований свидетельствуют о том, что комбинированная ЗГТ может повышать риск рака яичников сходным образом либо незначительно. Неизвестно, отличается ли риск при длительном приёме низкоактивных эстрогенов (таких, как Овестин®) от такового при монотерапии другими эстрогенами.\u003Cbr\u003EВенозные тромбоэмболии\u003Cbr\u003E- ЗГТ связана с увеличением риска развития венозной тромбоэмболии (ВТЭ), т.е. тромбоза глубоких вен или эмболии легочной артерии, в 1,3-3 раза. Вероятность развития ВТЭ выше в течение первого года применения ЗГТ, чем в более поздние сроки. Неизвестно, имеет ли препарат Овестин® такой же риск.\u003Cbr\u003E- У пациенток с подтверждённой тромбофилией риск ВТЭ высокий, а ЗГТ может дополнительно его увеличивать. В связи с этим таким женщинам ЗГТ противопоказана (см. раздел \"Противопоказания\").\u003Cbr\u003E- Обычно признанными факторами риска ВТЭ является прием эстрогенов, пожилой возраст, обширные хирургические вмешательства, длительная иммобилизация, ожирение (ИМТ \u003E30 кг/м2), беременность/послеродовый период, системная красная волчанка и рак. Не существует единого мнения относительно возможной роли варикозного расширения вен в развитии ВТЭ. После любого хирургического вмешательства необходимо проводить профилактику ВТЭ. Если длительная иммобилизация связана с плановой операцией, необходимо временно отменить ЗГТ за 4-6 недель до операции. Лечение следует возобновить после того, как женщина начнёт ходить.\u003Cbr\u003E- В отношении женщин, которые уже получают лечение антикоагулянтами, требуется тщательное рассмотрение соотношения польза-риск ЗГТ.\u003Cbr\u003E- Если Овестин® назначен в качестве \"пред- и послеоперационного лечения...\", следует рассмотреть вопрос о профилактике тромбозов.\u003Cbr\u003E- При отсутствии ВТЭ в анамнезе, но при наличии тромбоза в молодом возрасте у ближайших родственников пациентки ей можно предложить провести скрининговое обследование, предварительно обсудив все его ограничения (скрининг позволяет выявить только ряд тромбофилических нарушений). При выявлении тромбофилического дефекта, не соответствующего заболеванию у родственников, либо при обнаружении \"тяжёлого\" дефекта (например, дефицита антитромбина, протеина S или протеина С, либо сочетания этих дефектов) ЗГТ противопоказана.\u003Cbr\u003E- Если после начала лечения препаратом Овестин® развивается ВТЭ, то лечение необходимо прекратить. Пациентки должны быть информированы о необходимости немедленного обращения к врачу, если они почувствуют возможные признаки тромбоэмболии (например, болезненный отёк ноги, внезапная боль в груди, одышка).\u003Cbr\u003EИшемическая болезнь сердца (ИБС)\u003Cbr\u003E- В рандомизированных контролируемых исследованиях не получено результатов, которые свидетельствовали бы о том, что комбинированная терапия эстрогенами и прогестагенами и монотерапия эстрогенами могут предупреждать развитие инфаркта миокарда у женщин с ИБС и без неё.\u003Cbr\u003EМонотерапия эстрогенами\u003Cbr\u003E- По данным рандомизированных контролируемых исследований у женщин с удаленной маткой риск ИБС при монотерапии эстрогенами не увеличивается.\u003Cbr\u003E- Риск ишемической болезни сердца несколько увеличивается при комбинированной ЗГТ эстрогенами и прогестагенами у пациенток старше 60 лет.\u003Cbr\u003EИшемический инсульт\u003Cbr\u003E- Комбинированная терапия эстрогенами и прогестагенами и монотерапия эстрогенами сопряжены с увеличением риска ишемического инсульта в 1,5 раза. Относительный риск с возрастом и со временем после наступления менопаузы не меняется. Однако исходный риск инсульта в большой степени зависит от возраста, и общий риск инсульта на фоне ЗГТ с возрастом увеличивается. Риск геморрагического инсульта при ЗГТ не увеличивается.\u003Cbr\u003EДругие состояния\u003Cbr\u003E- Эстрогены могут вызывать задержку жидкости, и поэтому пациентки с нарушением функции почек и сердечно-сосудистой недостаточностью должны находиться под тщательным контролем.\u003Cbr\u003E- Эстриол является слабым антагонистом гонадотропина и не оказывает других значимых влияний на эндокринную систему.\u003Cbr\u003E- Когнитивная функция на фоне ЗГТ не улучшается. Получено свидетельство о повышенном риске развития деменции у женщин, начавших применять комбинированную терапию или монотерапию в непрерывном режиме после 65 лет."},{"name":"Взаимодействие","value":"В клинической практике не отмечено взаимодействия между препаратом Овестин и другими лекарственными средствами.\u003Cbr\u003EМетаболизм эстрогенов может усиливаться при их применении в сочетании с соединениями, которые индуцируют ферменты, участвующие в метаболизме лекарственных средств, в особенности, ферменты цитохрома Р450, например, такие как противосудорожные средства (например, фенобарбитал, фенитоин, карбамазепин) и противомикробные средства (например, рифампицин, рифабутин, невирапин, эфавиренц). Ритонавир и нелфинавир проявляют индуцирующие свойства при применении в сочетании со стероидными гормонами.\u003Cbr\u003EРастительные препараты, содержащие зверобой (Hypericum Perforatum), могут индуцировать метаболизм эстрогенов.\u003Cbr\u003EПовышенный метаболизм эстрогенов может привести к снижению их клинического эффекта.\u003Cbr\u003EЭстриол усиливает действие гиполипидемических лекарственных средств; ослабляет эффекты мужских половых гормонов, антикоагулянтов, антидепрессантов, диуретических, гипотензивных, гипогликемических лекарственных средств.\u003Cbr\u003EЛекарственные средства для общей анестезии, наркотические анальгетики, анксиолитики, некоторые гипотензивные лекарственные средства, этанол снижают эффективность препарата.\u003Cbr\u003EФолиевая кислота и препараты щитовидной железы усиливают действия эстриола."},{"name":"Регистрационный номер","value":"П N013327/01"},{"name":"Дата государственной регистрации","value":"10.01.2017"},{"name":"Владелец регистрационного удостоверения","value":"Аспен Фарма Трейдинг Лимитед"},{"name":"Страна бренда","value":"Ирландия"},{"name":"Страна-производитель","value":"Франция"},{"name":"Название препарата","value":"Овестин"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_2257828225689540965"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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1 699 ₽

  • Сегодня, самовывоз • 0 ₽
ЕАПТЕКА
Рейтинг 5 из 5
99Котзывов
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  • ФитоЭстрогены кш/раств. капс., 160 г, 30 шт.
    –31 %
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    ФитоЭстрогены кш/раств. капс., 160 г, 30 шт.

    Рейтинг товара: 4.8 из 5
    на основе 294 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 659 ₽ вместо 1 676
    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  • Бонисан капс., 60 шт., 1 уп.
    –51 %
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    Бонисан капс., 60 шт., 1 уп.

    Рейтинг товара: 4.6 из 5
    на основе 34 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 733 ₽ вместо 747
    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  • Дуожиналь капс., 0.4 г, 20 шт.
    –2 %
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    Дуожиналь капс., 0.4 г, 20 шт.

    Рейтинг товара: 4.7 из 5
    на основе 52 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 338 ₽ вместо 1 366
    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  • Эстрогиал Крем, 50 г, 10 шт., 1 уп.
    –2 %
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    Эстрогиал Крем, 50 г, 10 шт., 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 30 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 811 ₽ вместо 827
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  • Эстрогиал гель, 15 мл
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-j0v1bxyfb9h/toggleWishlist":{"skuId":"101992115032","productId":1763249269,"offerId":"5DA6mJ0pDwnqcYatQ-tkGw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQzMKI2rLyv+N+EjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcI9ZjkyAYQ2NbQ+fsCGIjE2Qcg7tzBBw==","sign":"XlW/Dqls26GJAEt29v1UbOkpHbAVgQFt1HIEErJrwr4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-j0v1bxyfb9h/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Эстрогиал гель, 15 мл

    Рейтинг товара: 4.8 из 5
    на основе 52 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 369 ₽ вместо 373
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  • Вагилак гель для интимной гигиены, 50 мл, 50 г
    –2 %
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    Вагилак гель для интимной гигиены, 50 мл, 50 г

    Рейтинг товара: 5 из 5
    на основе 32 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 820 ₽ вместо 836
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  • Эстрогиал Плюс крем, 1.2 г, 10 шт.
    –1 %
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    Эстрогиал Плюс крем, 1.2 г, 10 шт.

    Рейтинг товара: 4.6 из 5
    на основе 16 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 733 ₽ вместо 740
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  • Эстровэл капс., 30 шт.
    –2 %
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    Эстровэл капс., 30 шт.

    Рейтинг товара: 4.9 из 5
    на основе 36 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 807 ₽ вместо 823
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  • Менсе капс., 40 шт.
    –1 %
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    Менсе капс., 40 шт.

    Рейтинг товара: 4.6 из 5
    на основе 1057 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 891 ₽ вместо 900
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  • Нерей для женщин форте пантовые супп., 15 шт.
    ВАМ–35 %
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    Нерей для женщин форте пантовые супп., 15 шт.

    Рейтинг товара: 4.9 из 5
    на основе 15 оценок
    Цена 1 370 ₽ вместо 2 100
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  • Эпиген интим гель д/нар. прим. фл., 250 мл, 300 г, 1 шт., 1 уп.
    –22 %
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    Эпиген интим гель д/нар. прим. фл., 250 мл, 300 г, 1 шт., 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 1114 оценок
    Цена 1 620 ₽ вместо 2 090
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Инструкция

Показания к применению

- Заместительная гормональная терапия (ЗГТ) для лечения атрофии слизистой оболочки нижних отделов мочеполового тракта, связанной с эстрогеновой недостаточностью у женщин в постменопаузе;
- пред- и послеоперационная терапия женщин в постменопаузальном периоде, при хирургических вмешательствах при влагалищном доступе;
- как вспомогательное средство диагностики при получении атрофической картины цервикального мазка.

Противопоказания

- Установленный, имеющийся в анамнезе или подозреваемый рак молочной железы;
- диагностированные эстрогенозависимые опухоли или подозрение на них (например, рак эндометрия);
- кровотечение из влагалища неясной этиологии;
- нелеченная гиперплазия эндометрия;
- наличие венозных тромбозов в настоящее время и в анамнезе (тромбоз глубоких вен, легочная тромбоэмболия);
- подтвержденные тромбофилии (например, дефицит протеина С, протеина S или антитромбина (см. раздел "Особые указания"));
- тромбозы (венозные и артериальные) и тромбоэмболии в настоящее время или в анамнезе (в т.ч. тромбоз глубоких вен, тромбоэмболия легочной артерии, инфаркт миокарда, инсульт), цереброваскулярные нарушения; состояния, предшествующие тромбозу (в т.ч. транзиторные ишемические атаки, стенокардия) в настоящее время или в анамнезе;
- заболевание печени в острой стадии или заболевание печени в анамнезе, после которого показатели функции печени не вернулись к норме;
- установленная повышенная чувствительность к активному веществу или к любому из вспомогательных веществ препарата;
- порфирия.
С осторожностью:
С осторожностью (под тщательным наблюдением врача) препарат Овестин следует применять, если присутствуют любые из нижеперечисленных заболеваний или состояний, или эти заболевания или состояния отмечались ранее и/или ухудшались во время предшествующих беременностей или проводимого ранее гормонального лечения (т.к. они могут рецидивировать или ухудшиться во время лечения препаратом Овестин):
- лейомиома (фибромы матки) или эндометриоз;
- факторы риска тромбоэмболий (см. раздел "Особые указания");
- факторы риска эстрогенозависимых опухолей, например, 1-ая степень наследственности для рака молочной железы;
- артериальная гипертензия;
- доброкачественные опухоли печени (например, аденома печени);
- сахарный диабет с диабетической ангиопатией или без нее;
- желчекаменная болезнь;
- желтуха (в т.ч. в анамнезе во время предшествующей беременности);
- печеночная недостаточность;
- мигрень или (тяжёлая) головная боль;
- системная красная волчанка;
- гиперплазия эндометрия в анамнезе (см. раздел "Особые указания");
- эпилепсия;
- бронхиальная астма;
- отосклероз;
- семейная гиперлипопротеинемия;
- панкреатит.

Способ применения и дозы

Овестин суппозитории следует вводить во влагалище на ночь перед сном.
- При лечении атрофии слизистой оболочки нижних отделов мочеполового тракта:
1 суппозиторий в сутки в течение первых недель с последующим постепенным снижением дозы, основываясь на облегчении симптомов, до достижения поддерживающей дозы (т.е. 1 суппозиторий дважды в неделю).
- Пред- и послеоперационная терапия женщин в постменопаузальном периоде, при хирургических вмешательствах влагалищным доступом:
1 суппозиторий в сутки в течение 2 недель перед операцией; 1 суппозиторий дважды в неделю в течение 2 недель после операции.
- С диагностической целью при неясных результатах цитологического исследования шейки матки:
1 суппозиторий через день в течение недели перед взятием следующего мазка. Пропущенную дозу необходимо ввести в этот же день как только больная вспомнит об этом (доза не должна вводиться дважды в день). В дальнейшем аппликации проводят в соответствии с обычной схемой дозирования.
При начале или при продолжении лечения постменопаузальных симптомов необходимо применять наименьшую эффективную дозу в течение наиболее короткого промежутка времени.
У женщин, не получающих ЗГТ, или женщин, которые переводятся с непрерывного перорального приёма комбинированного препарата для ЗГТ, лечение препаратом Овестин можно начинать в любой день. Женщины, которые переходят с циклического режима приёма препаратов для ЗГТ, должны начинать лечение препаратом Овестин через одну неделю после отмены препаратов ЗГТ.
Полная инструкция
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Овестин супп. ваг.
Овестин супп. ваг., 0.5 мг, 15 шт.
5.0
(4)
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1 вопрос
Инструкция

1 699 ₽

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5.0
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  • Тукофитомол флюид CO2 супп. ваг. и рект., 2 г, 10 шт.
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    Тукофитомол флюид CO2 супп. ваг. и рект., 2 г, 10 шт.

    Цена 782 ₽ вместо 1 000
  • Тербинафин крем, 1%, 15 г, 1 шт.
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    Тербинафин крем, 1%, 15 г, 1 шт.

    Цена 79 ₽ вместо 80
  • ФитоЭстрогены кш/раств. капс., 160 г, 30 шт.
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    ФитоЭстрогены кш/раств. капс., 160 г, 30 шт.

    Цена 1 659 ₽ вместо 2 394
  • Эстрогиал Плюс крем, 1.2 г, 10 шт.
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    Эстрогиал Плюс крем, 1.2 г, 10 шт.

    Цена 733 ₽ вместо 740
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    Реклама
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  • Вагилак гель для интимной гигиены, 50 мл, 50 г
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    Вагилак гель для интимной гигиены, 50 мл, 50 г

    Цена 820 ₽ вместо 836
  • Дуожиналь капс., 0.4 г, 20 шт.
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    Дуожиналь капс., 0.4 г, 20 шт.

    Цена 1 204 ₽ вместо 1 228
  • Дипроспан сусп. д/ин., 2мг+5мг/мл, 1 мл, 1 шт.
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    Дипроспан сусп. д/ин., 2мг+5мг/мл, 1 мл, 1 шт.

    Цена 796 ₽
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 1 752 ₽ вместо 3 500
  • Эстровэл капс., 30 шт.
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    Эстровэл капс., 30 шт.

    Цена 807 ₽ вместо 823
  • Менсе капс., 40 шт.
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    Менсе капс., 40 шт.

    Цена 891 ₽ вместо 900
  • California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.
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    California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.

    Цена 1 103 ₽ вместо 1 581
  • Бонисан капс., 60 шт., 1 уп.
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    Бонисан капс., 60 шт., 1 уп.

    Цена 733 ₽ вместо 1 500
  • Лимфомиозот капли д/вн. приема, 30 мл
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    Лимфомиозот капли д/вн. приема, 30 мл

    Цена 910 ₽ вместо 1 081
  • Нерей для женщин форте пантовые супп., 15 шт.
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    Нерей для женщин форте пантовые супп., 15 шт.

    Цена 1 370 ₽ вместо 2 100
  • ЛимфоТранзит концентрат напитка фл., 100 мл
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 361 ₽ вместо 365
  • Пантенол скорая помощь д/лица и тела спрей, 130 мл, 130 г, 1 шт., 1 уп.
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    Пантенол скорая помощь д/лица и тела спрей, 130 мл, 130 г, 1 шт., 1 уп.

    Цена 250 ₽ вместо 253
  • {"widgets":{"@light/BannerCurtain":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_102_21/content/content/content/bannerCurtain":{"advertisementId":1641961,"impression":"/safeclick/data=SpQw45JhDGE6zDtOdUQO_JjcJ7QsILsk737E2y-zeNqtQEbko6PDDz5UEKtNQImnf2zRnFenePzvGB-HZaSSEzEJUtllP6Ag5Vgh_xpO405cSsRRX2K5N64487iaPd_WB8YeDzC6hF7k5pr2Ad4n439yi_muOyQPuxhKZh9w1BqeQ8P-hcTtafVv0QBG9G3KscJsUtr7JgxheESp-HInWAPTmNUfQzU6QbCRDckz9vMeXmwBz4ByCUNHjR889BlHVutoSGL3JVihBptwnFTMu76fcEAOu5oBEAj-RJEw-2WuNH5mb9PjG1JI1CKfJzWEIYF4uMcLzXpfCD8f-Oq3Lr3ToofOl3pP9uBOwA_2dZTueQHLnVYXndTKiOr_zBl828aNuzZ-NOdHr71sckY_0ben0TGAS-VkE10uTQblblLxX1K3hhcmm_KtdtyCMPGw6k5nrae0leXyzCO9t_06xN_kK7-i-_ljSvMhFauBLOXhukKmAtKOuqvdeSlHPeIKvqi95AOLqEs2YKJRzq4d8QvwCeKULU7bs2vaZkKvi0rz2hQT4vGQOoSZfFRp9ynlmXL2UURX-x2Fuzc9jisGcfeiCMYTt3928SlOO0h4SPJdUd6Xd-6WLeaaGXtdkDEdinuwzpL0WU05v7KWruCnUFpG49uI7okHibfPG3Otj9hjuSiKzzpJwzFDPcY9GaDsQ7_5uGzxpJnfOpGAhHwVEX4i-Hboo1fdvGOmmN7q8bDUn3dfSE0bY0pl5fMqZ-kEOpAQjG1Wcagrcj3m7pcZwTV8Qs8N-KOneyLEcqeGDd5sTATXgTToD834YqE_NsUWt-pf_SNe7rvhVO5YJUkmsc4S8h0fwzOVZhw-Y_fzaUnf6RhpFJEPsLzSCpQfIPCHMLtof2V1fkoSqiTmsEtAYjD4Rr3fs50q3ysXKpK93UgJ9T2qOZDnNR8RuRPlImgRcf1b3FXIS1kBzPzMm_vVjT0Cg08UylD2Y1g4nGVI7jeOI4hENwiXUc2433bPOnhC0gAZFk2oKXaPn7yGbB5z419_AjMgCgQnHGyWqQCYfdpR9Lpcikv6fXwd4PwMM-btghO407vTrIE,/b64e=1/sign=b11eec4f54365549b40b22bdd4dc0f4f/keyno=MARKET_1/*"}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_102_21/content/content/content/bannerCurtain":{"name":"@light/BannerCurtain"}}}
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    Реклама
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  • Argitos Коллоидное серебро спрей д/мест. прим. фл., 30 мл, 40 г, нейтральный
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    Argitos Коллоидное серебро спрей д/мест. прим. фл., 30 мл, 40 г, нейтральный

    Цена 365 ₽ вместо 395
  • Эпиген интим гель д/нар. прим. фл., 250 мл, 300 г, 1 шт., 1 уп.
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    Эпиген интим гель д/нар. прим. фл., 250 мл, 300 г, 1 шт., 1 уп.

    Цена 1 620 ₽ вместо 2 090
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