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Пантопразол-Акрихин таб. п/о кш/раств., 20 мг, 30 шт.

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Коротко о товаре

Артикул Маркета
4547766383
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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22,57 мг (в пересчете на пантопразол - 20 мг);\u003Cbr /\u003Eвспомогательные вещества: натрия карбонат безводный, маннитол, кросповидон, повидон (тип К90), кальция стеарат;\u003Cbr /\u003Eзащитная оболочка: готовая смесь \"ОПАДРАЙ\" бесцветная [гипромеллоза-2910, триацетин, тальк];\u003Cbr /\u003Eкишечнорастворимая оболочка: готовая смесь \"АКРИЛ-ИЗ\" желтого цвета [метакриловой кислоты и этилакрилата сополимер [1:1], тальк, титана диоксид, оксид железа желтый, кремния диоксид коллоидный безводный, натрия гидрокарбонат, натрия лаурилсульфат], триэтилцитрат.\u003Cbr\u003E1 таблетка 40 мг содержит:\u003Cbr\u003Eдействующее вещество: пантопразола натрия сесквигидрат - 45,10 мг (в пересчете на пантопразол - 40 мг);\u003Cbr\u003Eвспомогательные вещества: натрия карбонат безводный, маннитол, кросповидон, повидон (тип К90), кальция стеарат;\u003Cbr\u003Eзащитная оболочка: готовая смесь \"ОПАДРАЙ\" бесцветная [гипромеллоза-2910, триацетин, тальк];\u003Cbr\u003Eкишечнорастворимая оболочка: готовая смесь \"АКРИЛ-ИЗ\" желтого цвета [метакриловой кислоты и этилакрилата сополимер [1:1], тальк, титана диоксид, оксид железа желтый, кремния диоксид коллоидный безводный, натрия гидрокарбонат, натрия лаурилсульфат], триэтилцитрат."},{"name":"Действующее вещество","value":"Пантопразол","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28710341"]}}},{"name":"Способ применения и дозы","value":"для дозировки 20 мг:\u003Cbr\u003EПантопразол-Акрихин принимают внутрь, до еды, не разжевывая и не измельчая, запивая достаточным количеством жидкости по 20 мг в сутки. \u003Cbr\u003EДля достижения положительной динамики в устранении симптомов может потребоваться прием препарата в течение 2-3 дней, однако, для полного устранения симптомов может потребоваться применение препарата в течение 7 дней. При ухудшении состояния в течение первых 3 дней лечения рекомендуется консультация врача. \u003Cbr\u003EПрием препарата следует прекратить сразу после исчезновения симптомов. \u003Cbr\u003EПрием препарата без консультации врача не должен превышать 4 недель. Если в течение 2 недель непрерывного приема препарата положительная динамика отсутствует, необходимо проконсультироваться с врачом. \u003Cbr\u003EНе следует принимать Пантопразол-Акрихин в целях профилактики. \u003Cbr\u003EНе требуется коррекции дозы у пожилых пациентов и пациентов с почечной или печеночной недостаточностью.\u003Cbr\u003Eдля дозировки 40 мг:\u003Cbr\u003EПантопразол-Акрихин принимают внутрь, до еды, не разжевывая и не измельчая, запивая достаточным количеством жидкости.\u003Cbr\u003EЯзвенная болезнь желудка и двенадцатиперстной кишки, эрозивный гастрит (в том числе, связанные с приемом нестероидных противовоспалительных препаратов НПВП)\u003Cbr\u003EПо 40-80 мг в сутки.\u003Cbr\u003EКурс лечения - 2 недели при обострении язвенной болезни двенадцатиперстной кишки, если этого времени недостаточно, то заживление обычно может быть достигнуто в течение последующих 2-х недель терапии. Курс лечения 4-8 недель при обострении язвенной болезни желудка и эрозивном гастрите.\u003Cbr\u003EЭрадикация Helicobacter pylori\u003Cbr\u003EРекомендованы следующие комбинации:\u003Cbr\u003E1. Пантопразол-Акрихин по 40 мг 2 раза в сутки + амоксициллин по 1000 мг 2 раза в сутки + кларитромицин по 500 мг 2 раза в сутки\u003Cbr\u003E2. Пантопразол-Акрихин по 40 мг 2 раза в сутки + метронидазол по 500 мг 2 раза в сутки + кларитромицин по 500 мг 2 раза в сутки\u003Cbr\u003E3. Пантопразол-Акрихин по 40 мг 2 раза в сутки + амоксициллин по 1000 мг 2 раза в сутки + метронидазол по 500 мг 2 раза в сутки.\u003Cbr\u003EКурс лечения - 7-14 дней.\u003Cbr\u003EСиндром Золлингера-Эллисона\u003Cbr\u003EДля длительного лечения синдрома Золлингера-Эллисона и других патологических гиперсекреторных состояний, лечение следует начинать с суточной дозы 80 мг (2 таблетки Пантопразол-Акрихин по 40 мг). Затем, при необходимости, дозу можно повышать или уменьшать, в зависимости от показателей кислотности желудочного сока.\u003Cbr\u003EДозы выше 80 мг в день следует разделять и применять два раза в день. Возможно временное повышение дозы пантопразола выше 160 мг, но оно не должно продолжаться дольше, чем это требуется для достижения контроля кислотности.\u003Cbr\u003EПродолжительность лечения при синдроме Золлингера-Эллисона и при других патологических гиперсекреторных состояниях не ограничена, и сроки терапии могут определяться в зависимости от клинической необходимости.\u003Cbr\u003EУ пациентов с выраженными нарушениями функции печени суточная доза пантопразола не должна превышать 20 мг в сутки (1 таблетка пантопразола 20 мг). В связи с этим, применение пантопразола в дозировке 40 мг у данной группы пациентов не рекомендуется. Следует регулярно контролировать уровень печеночных ферментов во время лечения пантопразолом, особенно при длительном применении препарата. В случае повышения уровня печеночных ферментов лечение следует прекратить.\u003Cbr\u003EНе требуется коррекции дозы у пожилых пациентов и пациентов с почечной недостаточностью.\u003Cbr\u003EВ связи с отсутствием данных о применении препарата Пантопразол-Акрихин в составе комбинированной антимикробной терапии в отношении Helicobacter pylori у пациентов с нарушением функции почек, а также у пациентов со средней и тяжелой степенью печеночной недостаточности, препарат применять не следует."},{"name":"Побочные действия","value":"При приеме препарата Пантопразол-Акрихин в соответствии с показаниями и в рекомендуемых дозах нежелательные реакции возникают крайне редко. Наиболее частыми нежелательными реакциями являются диарея и головная боль - наблюдаются примерно у 1% пациентов.\u003Cbr /\u003EНиже приводятся данные о нежелательных реакциях в зависимости от частоты их возникновения:\u003Cbr /\u003EОчень часто ≥ 1/10\u003Cbr /\u003EЧасто ≥ 1/100 и \u003C 1/10\u003Cbr /\u003EНечасто ≥ 1/1000 и \u003C 1/100\u003Cbr /\u003EРедко≥1/10000 и \u003C 1/1000\u003Cbr /\u003EОчень редко \u003C1/10000, включая отдельные случаи\u003Cbr /\u003EЧастота неизвестна (невозможно оценить на основании имеющихся данных).\u003Cbr /\u003EНарушения со стороны кровеносной и лимфатической системы:\u003Cbr /\u003EРедко: Агранулоцитоз.\u003Cbr /\u003EОчень редко: Тромбоцитопения, лейкопения, панцитопения.\u003Cbr /\u003EНарушения со стороны нервной системы:\u003Cbr /\u003EНечасто: Головная боль, головокружение.\u003Cbr /\u003EРедко: Нарушения вкуса.\u003Cbr /\u003EНарушения со стороны органов зрения:\u003Cbr /\u003EРедко: Нарушение зрения (затуманивание).\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr /\u003EЧасто: Полипы фундальных желез желудка (доброкачественные).\u003Cbr /\u003EНечасто: Диарея, тошнота/рвота, вздутие живота и метеоризм, запор, сухость во рту, дискомфорт и боли в животе.\u003Cbr /\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr /\u003EЧастота неизвестна: Интерстициальный нефрит.\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr /\u003EНечасто: Экзантема/сыпь, зуд, дерматит.\u003Cbr /\u003EРедко: Крапивница, ангионевротический отек.\u003Cbr /\u003EЧастота неизвестна: Злокачественная экссудативная эритема (синдром Стивенса-Джонсона), экссудативная многоформная эритема, токсический эпидермальный некролиз, светочувствительность, подострая кожная красная волчанка.\u003Cbr /\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr /\u003EНечасто: Перелом запястья, бедра и позвоночника.\u003Cbr /\u003EРедко: Артралгия, миалгия.\u003Cbr /\u003EНарушения со стороны обмена веществ:\u003Cbr /\u003EРедко: Гиперлипидемия и повышенная концентрация липидов (триглицеридов, холестерина), изменение массы тела.\u003Cbr /\u003EЧастота неизвестна: Гипонатриемия, гипомагниемия.\u003Cbr /\u003EОбщие расстройства:\u003Cbr /\u003EНечасто: Слабость, утомляемость и недомогание.\u003Cbr /\u003EРедко: Повышение температуры тела, периферические отеки.\u003Cbr /\u003EНарушения со стороны иммунной системы:\u003Cbr /\u003EРедко: Гиперчувствительность (в том числе анафилактические реакции и анафилактический шок).\u003Cbr /\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr /\u003EНечасто: Повышение активности печеночных ферментов (трансаминаз, γ-глутаминтрансферазы).\u003Cbr /\u003EРедко: Повышение уровня билирубина.\u003Cbr /\u003EЧастота неизвестна: Гепатоцеллюлярные повреждения, желтуха, печёночно-клеточная недостаточность.\u003Cbr /\u003EНарушения со стороны половых органов и молочной железы:\u003Cbr /\u003EРедко: Гинекомастия.\u003Cbr /\u003EНечасто: Нарушения сна.\u003Cbr /\u003EНарушения со стороны психики:\u003Cbr /\u003EРедко: Депрессия (включая обострения имеющихся расстройств).\u003Cbr /\u003EОчень редко: Дезориентация (включая обострения имеющихся расстройств).\u003Cbr /\u003EЧастота неизвестна: Галлюцинации, спутанность сознания (в особенности у предрасположенных к этому пациентов), а также возможное обострение симптомов при их существовании до начала терапии."},{"name":"Фармакологическое действие","value":"Ингибитор протонного насоса (Н+ К+ АТФ-азы). Блокирует заключительную стадию секреции соляной кислоты независимо от природы раздражителя.\u003Cbr /\u003EПантопразол является замещенным бензимидазолом, подавляющим секрецию соляной кислоты в желудке путем специфической блокады протонных насосов париетальных клеток. Пантопразол трансформируется в свою активную форму в условиях кислой среды в париетальных клетках, где он подавляет активность фермента Н+ К+ АТФ-азы, т.е. блокирует заключительный этап образования соляной кислоты в желудке. Подавление активности является дозозависимым и, в результате, снижается как базальная, так и стимулированная секреция кислоты.\u003Cbr /\u003EПри лечении пантопразолом, как и при использовании других ингибиторов протонного насоса и блокаторов Н2-рецепторов, снижается кислотность в желудке и, тем самым, повышается уровень гастрина пропорционально снижению кислотности. Повышение уровня гастрина обратимо. Поскольку пантопразол связывает фермент дистально по отношению к клеточному рецептору, он может ингибировать секрецию соляной кислоты независимо от стимуляции другими веществами (ацетилхолин, гистамин, гастрин).\u003Cbr /\u003EТакже повышается содержание хромогранина A (CgA) в сыворотке крови вследствие снижения секреции соляной кислоты. Повышенное содержание CgA может искажать результаты диагностических исследований для выявления нейроэндокринных опухолей.\u003Cbr /\u003EАнтисекреторная активность. После первого перорального приема 20 мг препарата Пантопразол-Акрихин снижение секреции желудочного сока на 24 % наступает через 2,5-3,5 ч и на 26% через 24,5-25,5 ч. После перорального приема пантопразола однократно в сутки в течение 7 дней его антисекреторная активность, измеренная через 2,5-3,5 ч после приема, возрастает до 56%, а спустя 24,5-25,5 ч - до 50%.\u003Cbr /\u003EПри язвенной болезни двенадцатиперстной кишки, ассоциированной с Helicobacter pylori, снижение желудочной секреции повышает чувствительность микроорганизмов к антибиотикам. Не влияет на моторику желудочно-кишечного тракта. Секреторная активность нормализуется через 3-4 дня после окончания приема.\u003Cbr /\u003EПо сравнению с другими ингибиторами протонного насоса Пантопразол-Акрихин имеет большую химическую стабильность при нейтральном pH, и меньший потенциал взаимодействия с оксидазной системой печени, зависящей от цитохрома Р450. Поэтому не наблюдалось клинически значимого взаимодействия между препаратом Пантопразол-Акрихин и многими другими препаратами."},{"name":"Фармакологическая группа","value":"ингибиторы протонного насоса"},{"name":"Форма выпуска","value":"таблетки, покрытые кишечнорастворимой оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"До настоящего времени явлений передозировки в результате применения препаратов пантопразола отмечено не было. Дозы до 240 мг вводились внутривенно в течение 2 минут и переносились хорошо.\u003Cbr\u003EВ случае передозировки при наличии клинических проявлений интоксикации проводится симптоматическая и поддерживающая терапия.\u003Cbr\u003EПантопразол не выводится посредством гемодиализа."},{"name":"Применение при беременности и кормлении грудью","value":"Применение во время беременности\u003Cbr /\u003EВ связи с отсутствием данных о применении пантопразола у беременных женщин, в качестве меры предосторожности, необходимо исключить использование препарата Пантопразол-Акрихин во время беременности.\u003Cbr /\u003EГрудное вскармливание\u003Cbr /\u003EПантопразол и его метаболиты были обнаружены в грудном молоке. Эффект пантопразола на новорожденных/детей грудного возраста неизвестен. Пантопразол-Акрихин не следует применять в период кормления грудью. В случае необходимости применения препарата в период лактации грудное вскармливание следует прекратить.\u003Cbr /\u003EФертильность\u003Cbr /\u003EДанные о воздействии препарата Пантопразол-Акрихин на фертильность у человека отсутствуют. Доклинические исследования показали отсутствие эффекта на мужскую или женскую фертильность."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Следует воздержаться от управления транспортными средствами и другими механизмами, требующими повышенного внимания, из-за вероятности головокружений и нарушения зрения."},{"name":"Особые указания","value":"Перед началом лечения препаратом Пантопразол-Акрихин следует исключить возможность злокачественного новообразования, поскольку препарат может маскировать симптомы и отсрочить правильную постановку диагноза. \u003Cbr\u003EПациенты должны проконсультироваться с врачом, если им предстоит проведение эндоскопии или мочевинного дыхательного теста. \u003Cbr\u003EПациенты должны проконсультироваться с врачом, если имеются следующие случаи: \u003Cbr\u003E-\tнепреднамеренная потеря веса, анемия, желудочно-кишечное кровотечение, расстройство глотания, постоянная рвота или рвота с кровью. В этих случаях прием препарата может частично облегчить симптомы и отсрочить правильную диагностику; \u003Cbr\u003E-\tранее перенесенное хирургическое вмешательство на желудочно-кишечном тракте или язва желудка; \u003Cbr\u003E-\tнепрерывное симптоматическое лечение диспепсии и изжоги в течение 4 недель и бо-лее; \u003Cbr\u003E-\tзаболевания печени, в том числе желтуха и печеночная недостаточность; \u003Cbr\u003E-\tдругие серьезные заболевания, ухудшающие общее состояние здоровья. \u003Cbr\u003EПациенты в возрасте старше 55 лет, при наличии новых или недавно изменившихся симптомов, должны проконсультироваться с врачом. \u003Cbr\u003EПациентам не следует рассчитывать на мгновенное устранение симптомов недомогания. Облегчение симптомов возможно после приблизительно одного дня приема пантопразола, также необходимо учитывать, что для полного устранения изжоги может понадобиться приблизительно 7 дней. \u003Cbr\u003EПри приеме препаратов, снижающих кислотность желудочного сока, незначительно повышается риск желудочно-кишечных инфекций, возбудителями которых являются бактерии рода Salmonella spp., Campylobacter spp. или C. difficile. \u003Cbr\u003EПри лечении ингибиторами протонного насоса очень редко отмечается развитие подо-строй кожной красной волчанки (ПККВ). При возникновении поражений кожи, особенно на участках, подвергшихся воздействию солнечных лучей, а также при наличии сопутствующей артралгии, пациент должен немедленно обратиться за медицинской помощью, и врачу следует оценить необходимость прекращения лечения препаратом Пантопразол-Акрихин. Возникновение ПККВ после предшествующего лечения ингибитором протон-ного насоса может повысить риск развития ПККВ при лечении другими ингибиторами протонного насоса.\u003Cbr\u003EПри проведении лабораторных исследований необходимо учитывать, что повышенное содержание CgA в сыворотке крови может искажать результаты диагностических исследований для выявления нейроэндокринных опухолей. В связи с этим применение препарата Пантопразол-Акрихин следует прекратить не менее чем за 5 дней до проведения исследования содержания CgA. Если содержание CgA и гастрина не возвратилось к нормальным значениям после первого определения, то исследование следует повторить через 14 дней после прекращения приема ингибитора протонного насоса. \u003Cbr\u003EПрепарат предназначен для кратковременного применения (до 4 недель). \u003Cbr\u003EПри длительном приеме препарата могут возникать дополнительные риски, и необходимо обратиться к врачу для назначения препарата с последующим регулярным медицинским наблюдением. \u003Cbr\u003EСледующие дополнительные риски считаются значительными при продолжительном приеме препарата. \u003Cbr\u003EВлияние на абсорбцию Витамина В12 \u003Cbr\u003EПантопразол, как все ингибиторы протонного насоса, может снизить абсорбцию витамина В12 (цианокобаламин) в результате гипо- или ахлоргидрии. Это следует учитывать у пациентов со сниженными запасами в организме или факторами риска снижения абсорбции витамина B12 при длительной терапии или при наличии соответствующих клинических симптомов. \u003Cbr\u003EВлияние на переломы костей \u003Cbr\u003EИнгибиторы протонного насоса, особенно в больших дозах и при продолжительной терапии (\u003E1 года), могут незначительно увеличивать риск перелома бедра, запястья и позвоночника, преимущественно у пожилых людей или при наличии других известных факторов риска. Наблюдения показали, что ингибиторы протонного насоса могут увеличить общий риск переломов на 10 – 40 %. Это увеличение частично может быть обусловлено другими факторами риска. Пациенты с риском развития остеопороза должны получать лечение в соответствии с действующими клиническими рекомендациями, и у них должно быть соответствующее поступление витамина D и кальция в организм. \u003Cbr\u003EГипомагниемия: \u003Cbr\u003EУ пациентов, принимающих ингибиторы протонного насоса (ИПН), в том числе пантопразол, в течение как минимум трех месяцев, и, в большинстве случаев, в течение года наблюдалась тяжелая гипомагниемия. При этом возможно развитие серьезных проявлений гипомагниемии, таких как утомляемость, тетания, бред, судороги, головокружение и желудочковая аритмия, они могут начинаться незаметно и быть пропущены. У большинства пациентов с подобными нарушениями гипомагниемия была скорректирована после заместительной терапии магнием и прекращения приёма ИПН. \u003Cbr\u003EУ пациентов, которым предстоит длительное лечение, или пациентам, принимающим ИПН совместно с дигоксином или другими препаратами, которые могут вызвать гипомагниемию (например, диуретики), следует провести исследование содержания магния в сыворотке крови перед началом лечения ИПН и периодически осуществлять его контроль во время лечения. \u003Cbr\u003E"},{"name":"Взаимодействие","value":"Не рекомендуется одновременное применение других ингибиторов протонного насоса или блокаторов Н2-гистаминовых рецепторов без консультации врача.\u003Cbr /\u003EОдновременное применение препарата Пантопразол-Акрихин может уменьшить всасывание препаратов, биодоступность которых зависит от pH среды желудка (например, кетоконазол, итраконазол, позаконазол и других лекарственных средств, таких, как эрлотиниб).\u003Cbr /\u003EСовместное применение пантопразола и ингибиторов ВИЧ-протеазы, абсорбция которых зависит от кислотности (pH) желудочного сока, таких как атазанавир, нелфинавир, значительно снижает их биодоступность.\u003Cbr /\u003EВо время исследований по изучению лекарственного взаимодействия не было выявлено клинически значимых взаимодействий при применении препаратов пантопразола в следующих случаях:\u003Cbr /\u003E- у пациентов с заболеваниями сердечно-сосудистой системы, принимающих сердечные гликозиды (дигоксин), блокаторы медленных кальциевых каналов (нифедипин), бета- адреноблокаторы (метопролол);\u003Cbr /\u003E- у пациентов с заболеваниями желудочно-кишечного тракта, принимающих антациды, антибиотики (амоксициллин, кларитромицин);\u003Cbr /\u003E- у пациентов, принимающих пероральные контрацептивы, содержащие левоноргестрел и этинилэстрадиол;\u003Cbr /\u003E- у пациентов, принимающих нестероидные противовоспалительные препараты (диклофенак, напроксен, пироксикам);\u003Cbr /\u003E- у пациентов с заболеваниями эндокринной системы, принимающих глибенкламид, лево- тироксин;\u003Cbr /\u003E- у пациентов с тревожными состояниями и расстройствами сна, принимающих диазепам;\u003Cbr /\u003E- у пациентов с эпилепсией, принимающих карбамазепин и фенитоин;\u003Cbr /\u003E- у пациентов, принимающих непрямые антикоагулянты, такие как варфарин и фенпрокумон, под контролем протромбинового времени и МНО в начале и по окончании лечения, а также во время нерегулярного приема пантопразола. Одновременно нужно отметить, что известны случаи увеличения МНО и протромбинового времени у пациентов, получавших ингибиторы протонного насоса вместе с варфарином или с фенпрокумоном. Увеличение МНО и протромбинового времени может приводить к патологическим кровотечениям, опасным для жизни. В связи с этим, такие пациенты должны находиться под наблюдением с целью своевременного выявления увеличения МНО и протромбинового времени.\u003Cbr /\u003EТакже отмечено отсутствие клинически значимого лекарственного взаимодействия с кофеином, этанолом, теофиллином.\u003Cbr /\u003EИмеются сообщения о повышении уровня метотрексата в крови у некоторых пациентов при его совместном применении в высоких дозах (например, 300 мг) с ингибиторами протонного насоса. Поэтому при использовании высоких доз метотрексата, например при раке или псориазе, может возникнуть необходимость в рассмотрении вопроса о временной отмене пантопразола."},{"name":"Регистрационный номер","value":"ЛП-005380"},{"name":"Дата государственной регистрации","value":"28.02.2019"},{"name":"Владелец регистрационного удостоверения","value":"АКРИХИН","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:11037214"]}}},{"name":"Изготовитель","value":"АКРИХИН"},{"name":"Фасовщик","value":"АКРИХИН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Пантопразол-Акрихин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18017907"]}}},{"name":"Срок годности","value":"24 мес."}]}},"fullSpecsGrouped":{"16164119386425689937":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"пищеварительная система"},{"name":"Назначение","value":"гастрит, гастроэзофагиальный рефлюкс, изжога, синдром Золлингера-Эллисона, язвенная болезнь желудка и двенадцатиперстной кишки"},{"name":"Показания к применению","value":"для дозировки 20 мг:\u003Cbr\u003EЛечение симптомов гастроэзофагеальной рефлюксной болезни легкой степени выраженности (таких, как изжога, кислая отрыжка) у взрослых.\u003Cbr\u003Eдля дозировки 40 мг:\u003Cbr\u003E- Язвенная болезнь желудка и двенадцатиперстной кишки (в фазе обострения), эрозивный гастрит (в том числе, связанные с приемом нестероидных противовоспалительных препаратов НПВП);\u003Cbr\u003E- синдром Золлингера-Эллисона;\u003Cbr\u003E- эрадикация Helicobacter pylori в комбинации с антибактериальными средствами."},{"name":"Противопоказания","value":"- Повышенная чувствительность к любому из компонентов препарата, а также к замещенным бензимидазолам;\u003Cbr /\u003E- диспепсия невротического генеза;\u003Cbr /\u003E- прием ингибиторов протеазы ВИЧ, таких как атазанавир и нелфинавир, абсорбция которых зависит от кислотности (pH) желудочного сока;\u003Cbr /\u003E- возраст до 18 лет;\u003Cbr /\u003E- беременность, период грудного вскармливания."},{"name":"Состав","value":"1 таблетка 20 мг содержит:\u003Cbr /\u003Eдействующее вещество: пантопразола натрия сесквигидрат - 22,57 мг (в пересчете на пантопразол - 20 мг);\u003Cbr /\u003Eвспомогательные вещества: натрия карбонат безводный, маннитол, кросповидон, повидон (тип К90), кальция стеарат;\u003Cbr /\u003Eзащитная оболочка: готовая смесь \"ОПАДРАЙ\" бесцветная [гипромеллоза-2910, триацетин, тальк];\u003Cbr /\u003Eкишечнорастворимая оболочка: готовая смесь \"АКРИЛ-ИЗ\" желтого цвета [метакриловой кислоты и этилакрилата сополимер [1:1], тальк, титана диоксид, оксид железа желтый, кремния диоксид коллоидный безводный, натрия гидрокарбонат, натрия лаурилсульфат], триэтилцитрат.\u003Cbr\u003E1 таблетка 40 мг содержит:\u003Cbr\u003Eдействующее вещество: пантопразола натрия сесквигидрат - 45,10 мг (в пересчете на пантопразол - 40 мг);\u003Cbr\u003Eвспомогательные вещества: натрия карбонат безводный, маннитол, кросповидон, повидон (тип К90), кальция стеарат;\u003Cbr\u003Eзащитная оболочка: готовая смесь \"ОПАДРАЙ\" бесцветная [гипромеллоза-2910, триацетин, тальк];\u003Cbr\u003Eкишечнорастворимая оболочка: готовая смесь \"АКРИЛ-ИЗ\" желтого цвета [метакриловой кислоты и этилакрилата сополимер [1:1], тальк, титана диоксид, оксид железа желтый, кремния диоксид коллоидный безводный, натрия гидрокарбонат, натрия лаурилсульфат], триэтилцитрат."},{"name":"Действующее вещество","value":"Пантопразол"},{"name":"Способ применения и дозы","value":"для дозировки 20 мг:\u003Cbr\u003EПантопразол-Акрихин принимают внутрь, до еды, не разжевывая и не измельчая, запивая достаточным количеством жидкости по 20 мг в сутки. \u003Cbr\u003EДля достижения положительной динамики в устранении симптомов может потребоваться прием препарата в течение 2-3 дней, однако, для полного устранения симптомов может потребоваться применение препарата в течение 7 дней. При ухудшении состояния в течение первых 3 дней лечения рекомендуется консультация врача. \u003Cbr\u003EПрием препарата следует прекратить сразу после исчезновения симптомов. \u003Cbr\u003EПрием препарата без консультации врача не должен превышать 4 недель. Если в течение 2 недель непрерывного приема препарата положительная динамика отсутствует, необходимо проконсультироваться с врачом. \u003Cbr\u003EНе следует принимать Пантопразол-Акрихин в целях профилактики. \u003Cbr\u003EНе требуется коррекции дозы у пожилых пациентов и пациентов с почечной или печеночной недостаточностью.\u003Cbr\u003Eдля дозировки 40 мг:\u003Cbr\u003EПантопразол-Акрихин принимают внутрь, до еды, не разжевывая и не измельчая, запивая достаточным количеством жидкости.\u003Cbr\u003EЯзвенная болезнь желудка и двенадцатиперстной кишки, эрозивный гастрит (в том числе, связанные с приемом нестероидных противовоспалительных препаратов НПВП)\u003Cbr\u003EПо 40-80 мг в сутки.\u003Cbr\u003EКурс лечения - 2 недели при обострении язвенной болезни двенадцатиперстной кишки, если этого времени недостаточно, то заживление обычно может быть достигнуто в течение последующих 2-х недель терапии. Курс лечения 4-8 недель при обострении язвенной болезни желудка и эрозивном гастрите.\u003Cbr\u003EЭрадикация Helicobacter pylori\u003Cbr\u003EРекомендованы следующие комбинации:\u003Cbr\u003E1. Пантопразол-Акрихин по 40 мг 2 раза в сутки + амоксициллин по 1000 мг 2 раза в сутки + кларитромицин по 500 мг 2 раза в сутки\u003Cbr\u003E2. Пантопразол-Акрихин по 40 мг 2 раза в сутки + метронидазол по 500 мг 2 раза в сутки + кларитромицин по 500 мг 2 раза в сутки\u003Cbr\u003E3. Пантопразол-Акрихин по 40 мг 2 раза в сутки + амоксициллин по 1000 мг 2 раза в сутки + метронидазол по 500 мг 2 раза в сутки.\u003Cbr\u003EКурс лечения - 7-14 дней.\u003Cbr\u003EСиндром Золлингера-Эллисона\u003Cbr\u003EДля длительного лечения синдрома Золлингера-Эллисона и других патологических гиперсекреторных состояний, лечение следует начинать с суточной дозы 80 мг (2 таблетки Пантопразол-Акрихин по 40 мг). Затем, при необходимости, дозу можно повышать или уменьшать, в зависимости от показателей кислотности желудочного сока.\u003Cbr\u003EДозы выше 80 мг в день следует разделять и применять два раза в день. Возможно временное повышение дозы пантопразола выше 160 мг, но оно не должно продолжаться дольше, чем это требуется для достижения контроля кислотности.\u003Cbr\u003EПродолжительность лечения при синдроме Золлингера-Эллисона и при других патологических гиперсекреторных состояниях не ограничена, и сроки терапии могут определяться в зависимости от клинической необходимости.\u003Cbr\u003EУ пациентов с выраженными нарушениями функции печени суточная доза пантопразола не должна превышать 20 мг в сутки (1 таблетка пантопразола 20 мг). В связи с этим, применение пантопразола в дозировке 40 мг у данной группы пациентов не рекомендуется. Следует регулярно контролировать уровень печеночных ферментов во время лечения пантопразолом, особенно при длительном применении препарата. В случае повышения уровня печеночных ферментов лечение следует прекратить.\u003Cbr\u003EНе требуется коррекции дозы у пожилых пациентов и пациентов с почечной недостаточностью.\u003Cbr\u003EВ связи с отсутствием данных о применении препарата Пантопразол-Акрихин в составе комбинированной антимикробной терапии в отношении Helicobacter pylori у пациентов с нарушением функции почек, а также у пациентов со средней и тяжелой степенью печеночной недостаточности, препарат применять не следует."},{"name":"Побочные действия","value":"При приеме препарата Пантопразол-Акрихин в соответствии с показаниями и в рекомендуемых дозах нежелательные реакции возникают крайне редко. Наиболее частыми нежелательными реакциями являются диарея и головная боль - наблюдаются примерно у 1% пациентов.\u003Cbr /\u003EНиже приводятся данные о нежелательных реакциях в зависимости от частоты их возникновения:\u003Cbr /\u003EОчень часто ≥ 1/10\u003Cbr /\u003EЧасто ≥ 1/100 и \u003C 1/10\u003Cbr /\u003EНечасто ≥ 1/1000 и \u003C 1/100\u003Cbr /\u003EРедко≥1/10000 и \u003C 1/1000\u003Cbr /\u003EОчень редко \u003C1/10000, включая отдельные случаи\u003Cbr /\u003EЧастота неизвестна (невозможно оценить на основании имеющихся данных).\u003Cbr /\u003EНарушения со стороны кровеносной и лимфатической системы:\u003Cbr /\u003EРедко: Агранулоцитоз.\u003Cbr /\u003EОчень редко: Тромбоцитопения, лейкопения, панцитопения.\u003Cbr /\u003EНарушения со стороны нервной системы:\u003Cbr /\u003EНечасто: Головная боль, головокружение.\u003Cbr /\u003EРедко: Нарушения вкуса.\u003Cbr /\u003EНарушения со стороны органов зрения:\u003Cbr /\u003EРедко: Нарушение зрения (затуманивание).\u003Cbr /\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr /\u003EЧасто: Полипы фундальных желез желудка (доброкачественные).\u003Cbr /\u003EНечасто: Диарея, тошнота/рвота, вздутие живота и метеоризм, запор, сухость во рту, дискомфорт и боли в животе.\u003Cbr /\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr /\u003EЧастота неизвестна: Интерстициальный нефрит.\u003Cbr /\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr /\u003EНечасто: Экзантема/сыпь, зуд, дерматит.\u003Cbr /\u003EРедко: Крапивница, ангионевротический отек.\u003Cbr /\u003EЧастота неизвестна: Злокачественная экссудативная эритема (синдром Стивенса-Джонсона), экссудативная многоформная эритема, токсический эпидермальный некролиз, светочувствительность, подострая кожная красная волчанка.\u003Cbr /\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr /\u003EНечасто: Перелом запястья, бедра и позвоночника.\u003Cbr /\u003EРедко: Артралгия, миалгия.\u003Cbr /\u003EНарушения со стороны обмена веществ:\u003Cbr /\u003EРедко: Гиперлипидемия и повышенная концентрация липидов (триглицеридов, холестерина), изменение массы тела.\u003Cbr /\u003EЧастота неизвестна: Гипонатриемия, гипомагниемия.\u003Cbr /\u003EОбщие расстройства:\u003Cbr /\u003EНечасто: Слабость, утомляемость и недомогание.\u003Cbr /\u003EРедко: Повышение температуры тела, периферические отеки.\u003Cbr /\u003EНарушения со стороны иммунной системы:\u003Cbr /\u003EРедко: Гиперчувствительность (в том числе анафилактические реакции и анафилактический шок).\u003Cbr /\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr /\u003EНечасто: Повышение активности печеночных ферментов (трансаминаз, γ-глутаминтрансферазы).\u003Cbr /\u003EРедко: Повышение уровня билирубина.\u003Cbr /\u003EЧастота неизвестна: Гепатоцеллюлярные повреждения, желтуха, печёночно-клеточная недостаточность.\u003Cbr /\u003EНарушения со стороны половых органов и молочной железы:\u003Cbr /\u003EРедко: Гинекомастия.\u003Cbr /\u003EНечасто: Нарушения сна.\u003Cbr /\u003EНарушения со стороны психики:\u003Cbr /\u003EРедко: Депрессия (включая обострения имеющихся расстройств).\u003Cbr /\u003EОчень редко: Дезориентация (включая обострения имеющихся расстройств).\u003Cbr /\u003EЧастота неизвестна: Галлюцинации, спутанность сознания (в особенности у предрасположенных к этому пациентов), а также возможное обострение симптомов при их существовании до начала терапии."},{"name":"Фармакологическое действие","value":"Ингибитор протонного насоса (Н+ К+ АТФ-азы). Блокирует заключительную стадию секреции соляной кислоты независимо от природы раздражителя.\u003Cbr /\u003EПантопразол является замещенным бензимидазолом, подавляющим секрецию соляной кислоты в желудке путем специфической блокады протонных насосов париетальных клеток. Пантопразол трансформируется в свою активную форму в условиях кислой среды в париетальных клетках, где он подавляет активность фермента Н+ К+ АТФ-азы, т.е. блокирует заключительный этап образования соляной кислоты в желудке. Подавление активности является дозозависимым и, в результате, снижается как базальная, так и стимулированная секреция кислоты.\u003Cbr /\u003EПри лечении пантопразолом, как и при использовании других ингибиторов протонного насоса и блокаторов Н2-рецепторов, снижается кислотность в желудке и, тем самым, повышается уровень гастрина пропорционально снижению кислотности. Повышение уровня гастрина обратимо. Поскольку пантопразол связывает фермент дистально по отношению к клеточному рецептору, он может ингибировать секрецию соляной кислоты независимо от стимуляции другими веществами (ацетилхолин, гистамин, гастрин).\u003Cbr /\u003EТакже повышается содержание хромогранина A (CgA) в сыворотке крови вследствие снижения секреции соляной кислоты. Повышенное содержание CgA может искажать результаты диагностических исследований для выявления нейроэндокринных опухолей.\u003Cbr /\u003EАнтисекреторная активность. После первого перорального приема 20 мг препарата Пантопразол-Акрихин снижение секреции желудочного сока на 24 % наступает через 2,5-3,5 ч и на 26% через 24,5-25,5 ч. После перорального приема пантопразола однократно в сутки в течение 7 дней его антисекреторная активность, измеренная через 2,5-3,5 ч после приема, возрастает до 56%, а спустя 24,5-25,5 ч - до 50%.\u003Cbr /\u003EПри язвенной болезни двенадцатиперстной кишки, ассоциированной с Helicobacter pylori, снижение желудочной секреции повышает чувствительность микроорганизмов к антибиотикам. Не влияет на моторику желудочно-кишечного тракта. Секреторная активность нормализуется через 3-4 дня после окончания приема.\u003Cbr /\u003EПо сравнению с другими ингибиторами протонного насоса Пантопразол-Акрихин имеет большую химическую стабильность при нейтральном pH, и меньший потенциал взаимодействия с оксидазной системой печени, зависящей от цитохрома Р450. Поэтому не наблюдалось клинически значимого взаимодействия между препаратом Пантопразол-Акрихин и многими другими препаратами."},{"name":"Фармакологическая группа","value":"ингибиторы протонного насоса"},{"name":"Форма выпуска","value":"таблетки, покрытые кишечнорастворимой оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"До настоящего времени явлений передозировки в результате применения препаратов пантопразола отмечено не было. Дозы до 240 мг вводились внутривенно в течение 2 минут и переносились хорошо.\u003Cbr\u003EВ случае передозировки при наличии клинических проявлений интоксикации проводится симптоматическая и поддерживающая терапия.\u003Cbr\u003EПантопразол не выводится посредством гемодиализа."},{"name":"Применение при беременности и кормлении грудью","value":"Применение во время беременности\u003Cbr /\u003EВ связи с отсутствием данных о применении пантопразола у беременных женщин, в качестве меры предосторожности, необходимо исключить использование препарата Пантопразол-Акрихин во время беременности.\u003Cbr /\u003EГрудное вскармливание\u003Cbr /\u003EПантопразол и его метаболиты были обнаружены в грудном молоке. Эффект пантопразола на новорожденных/детей грудного возраста неизвестен. Пантопразол-Акрихин не следует применять в период кормления грудью. В случае необходимости применения препарата в период лактации грудное вскармливание следует прекратить.\u003Cbr /\u003EФертильность\u003Cbr /\u003EДанные о воздействии препарата Пантопразол-Акрихин на фертильность у человека отсутствуют. Доклинические исследования показали отсутствие эффекта на мужскую или женскую фертильность."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Следует воздержаться от управления транспортными средствами и другими механизмами, требующими повышенного внимания, из-за вероятности головокружений и нарушения зрения."},{"name":"Особые указания","value":"Перед началом лечения препаратом Пантопразол-Акрихин следует исключить возможность злокачественного новообразования, поскольку препарат может маскировать симптомы и отсрочить правильную постановку диагноза. \u003Cbr\u003EПациенты должны проконсультироваться с врачом, если им предстоит проведение эндоскопии или мочевинного дыхательного теста. \u003Cbr\u003EПациенты должны проконсультироваться с врачом, если имеются следующие случаи: \u003Cbr\u003E-\tнепреднамеренная потеря веса, анемия, желудочно-кишечное кровотечение, расстройство глотания, постоянная рвота или рвота с кровью. В этих случаях прием препарата может частично облегчить симптомы и отсрочить правильную диагностику; \u003Cbr\u003E-\tранее перенесенное хирургическое вмешательство на желудочно-кишечном тракте или язва желудка; \u003Cbr\u003E-\tнепрерывное симптоматическое лечение диспепсии и изжоги в течение 4 недель и бо-лее; \u003Cbr\u003E-\tзаболевания печени, в том числе желтуха и печеночная недостаточность; \u003Cbr\u003E-\tдругие серьезные заболевания, ухудшающие общее состояние здоровья. \u003Cbr\u003EПациенты в возрасте старше 55 лет, при наличии новых или недавно изменившихся симптомов, должны проконсультироваться с врачом. \u003Cbr\u003EПациентам не следует рассчитывать на мгновенное устранение симптомов недомогания. Облегчение симптомов возможно после приблизительно одного дня приема пантопразола, также необходимо учитывать, что для полного устранения изжоги может понадобиться приблизительно 7 дней. \u003Cbr\u003EПри приеме препаратов, снижающих кислотность желудочного сока, незначительно повышается риск желудочно-кишечных инфекций, возбудителями которых являются бактерии рода Salmonella spp., Campylobacter spp. или C. difficile. \u003Cbr\u003EПри лечении ингибиторами протонного насоса очень редко отмечается развитие подо-строй кожной красной волчанки (ПККВ). При возникновении поражений кожи, особенно на участках, подвергшихся воздействию солнечных лучей, а также при наличии сопутствующей артралгии, пациент должен немедленно обратиться за медицинской помощью, и врачу следует оценить необходимость прекращения лечения препаратом Пантопразол-Акрихин. Возникновение ПККВ после предшествующего лечения ингибитором протон-ного насоса может повысить риск развития ПККВ при лечении другими ингибиторами протонного насоса.\u003Cbr\u003EПри проведении лабораторных исследований необходимо учитывать, что повышенное содержание CgA в сыворотке крови может искажать результаты диагностических исследований для выявления нейроэндокринных опухолей. В связи с этим применение препарата Пантопразол-Акрихин следует прекратить не менее чем за 5 дней до проведения исследования содержания CgA. Если содержание CgA и гастрина не возвратилось к нормальным значениям после первого определения, то исследование следует повторить через 14 дней после прекращения приема ингибитора протонного насоса. \u003Cbr\u003EПрепарат предназначен для кратковременного применения (до 4 недель). \u003Cbr\u003EПри длительном приеме препарата могут возникать дополнительные риски, и необходимо обратиться к врачу для назначения препарата с последующим регулярным медицинским наблюдением. \u003Cbr\u003EСледующие дополнительные риски считаются значительными при продолжительном приеме препарата. \u003Cbr\u003EВлияние на абсорбцию Витамина В12 \u003Cbr\u003EПантопразол, как все ингибиторы протонного насоса, может снизить абсорбцию витамина В12 (цианокобаламин) в результате гипо- или ахлоргидрии. Это следует учитывать у пациентов со сниженными запасами в организме или факторами риска снижения абсорбции витамина B12 при длительной терапии или при наличии соответствующих клинических симптомов. \u003Cbr\u003EВлияние на переломы костей \u003Cbr\u003EИнгибиторы протонного насоса, особенно в больших дозах и при продолжительной терапии (\u003E1 года), могут незначительно увеличивать риск перелома бедра, запястья и позвоночника, преимущественно у пожилых людей или при наличии других известных факторов риска. Наблюдения показали, что ингибиторы протонного насоса могут увеличить общий риск переломов на 10 – 40 %. Это увеличение частично может быть обусловлено другими факторами риска. Пациенты с риском развития остеопороза должны получать лечение в соответствии с действующими клиническими рекомендациями, и у них должно быть соответствующее поступление витамина D и кальция в организм. \u003Cbr\u003EГипомагниемия: \u003Cbr\u003EУ пациентов, принимающих ингибиторы протонного насоса (ИПН), в том числе пантопразол, в течение как минимум трех месяцев, и, в большинстве случаев, в течение года наблюдалась тяжелая гипомагниемия. При этом возможно развитие серьезных проявлений гипомагниемии, таких как утомляемость, тетания, бред, судороги, головокружение и желудочковая аритмия, они могут начинаться незаметно и быть пропущены. У большинства пациентов с подобными нарушениями гипомагниемия была скорректирована после заместительной терапии магнием и прекращения приёма ИПН. \u003Cbr\u003EУ пациентов, которым предстоит длительное лечение, или пациентам, принимающим ИПН совместно с дигоксином или другими препаратами, которые могут вызвать гипомагниемию (например, диуретики), следует провести исследование содержания магния в сыворотке крови перед началом лечения ИПН и периодически осуществлять его контроль во время лечения. \u003Cbr\u003E"},{"name":"Взаимодействие","value":"Не рекомендуется одновременное применение других ингибиторов протонного насоса или блокаторов Н2-гистаминовых рецепторов без консультации врача.\u003Cbr /\u003EОдновременное применение препарата Пантопразол-Акрихин может уменьшить всасывание препаратов, биодоступность которых зависит от pH среды желудка (например, кетоконазол, итраконазол, позаконазол и других лекарственных средств, таких, как эрлотиниб).\u003Cbr /\u003EСовместное применение пантопразола и ингибиторов ВИЧ-протеазы, абсорбция которых зависит от кислотности (pH) желудочного сока, таких как атазанавир, нелфинавир, значительно снижает их биодоступность.\u003Cbr /\u003EВо время исследований по изучению лекарственного взаимодействия не было выявлено клинически значимых взаимодействий при применении препаратов пантопразола в следующих случаях:\u003Cbr /\u003E- у пациентов с заболеваниями сердечно-сосудистой системы, принимающих сердечные гликозиды (дигоксин), блокаторы медленных кальциевых каналов (нифедипин), бета- адреноблокаторы (метопролол);\u003Cbr /\u003E- у пациентов с заболеваниями желудочно-кишечного тракта, принимающих антациды, антибиотики (амоксициллин, кларитромицин);\u003Cbr /\u003E- у пациентов, принимающих пероральные контрацептивы, содержащие левоноргестрел и этинилэстрадиол;\u003Cbr /\u003E- у пациентов, принимающих нестероидные противовоспалительные препараты (диклофенак, напроксен, пироксикам);\u003Cbr /\u003E- у пациентов с заболеваниями эндокринной системы, принимающих глибенкламид, лево- тироксин;\u003Cbr /\u003E- у пациентов с тревожными состояниями и расстройствами сна, принимающих диазепам;\u003Cbr /\u003E- у пациентов с эпилепсией, принимающих карбамазепин и фенитоин;\u003Cbr /\u003E- у пациентов, принимающих непрямые антикоагулянты, такие как варфарин и фенпрокумон, под контролем протромбинового времени и МНО в начале и по окончании лечения, а также во время нерегулярного приема пантопразола. Одновременно нужно отметить, что известны случаи увеличения МНО и протромбинового времени у пациентов, получавших ингибиторы протонного насоса вместе с варфарином или с фенпрокумоном. Увеличение МНО и протромбинового времени может приводить к патологическим кровотечениям, опасным для жизни. В связи с этим, такие пациенты должны находиться под наблюдением с целью своевременного выявления увеличения МНО и протромбинового времени.\u003Cbr /\u003EТакже отмечено отсутствие клинически значимого лекарственного взаимодействия с кофеином, этанолом, теофиллином.\u003Cbr /\u003EИмеются сообщения о повышении уровня метотрексата в крови у некоторых пациентов при его совместном применении в высоких дозах (например, 300 мг) с ингибиторами протонного насоса. Поэтому при использовании высоких доз метотрексата, например при раке или псориазе, может возникнуть необходимость в рассмотрении вопроса о временной отмене пантопразола."},{"name":"Регистрационный номер","value":"ЛП-005380"},{"name":"Дата государственной регистрации","value":"28.02.2019"},{"name":"Владелец регистрационного удостоверения","value":"АКРИХИН"},{"name":"Изготовитель","value":"АКРИХИН"},{"name":"Фасовщик","value":"АКРИХИН"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Пантопразол-Акрихин"},{"name":"Срок годности","value":"24 мес."}]}],"transitionId":"tr_13084876820371178430"}}}}
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Цена с картой Яндекс Пэй:371 ₽

Скидка: 2%
–2 %
Вместо: 379 ₽
  • 19 июня, курьер Маркета • 249 ₽
POLZAru
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Ещё может подойти

  • Гепатрин капс., 120 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-xzv6uqjpgad/toggleWishlist":{"skuId":"101768642806","productId":1400799509,"offerId":"BEkmqidXLKn-dw6mRLbRjg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvYGVtYHnsokKEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIlYL6mwUQ9oGJj/sCGNW7oQYg2tnBBw==","sign":"6idDRoxa6pSgFuxMTHdMnwMzlQDN/ZCf4dO9FSk0oxY="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-xzv6uqjpgad/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гепатрин капс., 120 шт.

    Рейтинг товара: 4.8 из 5
    на основе 885 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 886 ₽ вместо 895
    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  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
    –22 %
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    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Рейтинг товара: 4.5 из 5
    на основе 1299 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 812 ₽ вместо 820
    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  • Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.
    –8 %
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    Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 765 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 569 ₽ вместо 575
    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  • Стоп-Изжокс таб. жев., 15 шт., малина, 1 уп.
    –1 %
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    Стоп-Изжокс таб. жев., 15 шт., малина, 1 уп.

    Рейтинг товара: 4.5 из 5
    на основе 120 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 176 ₽ вместо 178
    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  • ГепатоЛИПИНТ капс., 60 шт.
    –51 %
    ПРОМОКОД –20 %
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    ГепатоЛИПИНТ капс., 60 шт.

    Рейтинг товара: 4.9 из 5
    на основе 55 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 583 ₽ вместо 595
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  • Фитолакс таб. жев., 20 шт., абрикос, 1 уп.
    –2 %
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    Фитолакс таб. жев., 20 шт., абрикос, 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 35 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 350 ₽ вместо 358
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  • Липроксол форте капс., 0.6 г, 90 шт., нейтральный, 1 уп.
    –24 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ry9w6284dc/toggleWishlist":{"skuId":"101829729883","productId":1772075205,"offerId":"6V1Eww_qCU-VY6WTHOoSZA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQvYGVtYHnsokKEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIxfH+zAYQ27yZrPsCGOzFvAQg2tnBBw==","sign":"eXZyutok61QAhvEYXr+ULFZrAFG6fwXWeqv/Rxg7cFQ="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-ry9w6284dc/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Липроксол форте капс., 0.6 г, 90 шт., нейтральный, 1 уп.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 058 ₽ вместо 2 100
    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  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
    –50 %
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 588 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 752 ₽ вместо 1 770
    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Пробиотик капли детск. фл., 5 мл, 1 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  • California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.
    –30 %
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    California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 727 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 103 ₽ вместо 1 114
    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  • Закофальк NMX таб., 30 шт., нейтральный
    –1 %
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    Закофальк NMX таб., 30 шт., нейтральный

    Рейтинг товара: 4.8 из 5
    на основе 18 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 104 ₽ вместо 1 115
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  • Erkapharm магния сульфат пор. для вн/приема, 25 г, 3 шт.
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    Erkapharm магния сульфат пор. для вн/приема, 25 г, 3 шт.

    Рейтинг товара: 2 из 5
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Инструкция

Показания к применению

для дозировки 20 мг:
Лечение симптомов гастроэзофагеальной рефлюксной болезни легкой степени выраженности (таких, как изжога, кислая отрыжка) у взрослых.
для дозировки 40 мг:
- Язвенная болезнь желудка и двенадцатиперстной кишки (в фазе обострения), эрозивный гастрит (в том числе, связанные с приемом нестероидных противовоспалительных препаратов НПВП);
- синдром Золлингера-Эллисона;
- эрадикация Helicobacter pylori в комбинации с антибактериальными средствами.

Противопоказания

- Повышенная чувствительность к любому из компонентов препарата, а также к замещенным бензимидазолам;
- диспепсия невротического генеза;
- прием ингибиторов протеазы ВИЧ, таких как атазанавир и нелфинавир, абсорбция которых зависит от кислотности (pH) желудочного сока;
- возраст до 18 лет;
- беременность, период грудного вскармливания.

Способ применения и дозы

для дозировки 20 мг:
Пантопразол-Акрихин принимают внутрь, до еды, не разжевывая и не измельчая, запивая достаточным количеством жидкости по 20 мг в сутки.
Для достижения положительной динамики в устранении симптомов может потребоваться прием препарата в течение 2-3 дней, однако, для полного устранения симптомов может потребоваться применение препарата в течение 7 дней. При ухудшении состояния в течение первых 3 дней лечения рекомендуется консультация врача.
Прием препарата следует прекратить сразу после исчезновения симптомов.
Прием препарата без консультации врача не должен превышать 4 недель. Если в течение 2 недель непрерывного приема препарата положительная динамика отсутствует, необходимо проконсультироваться с врачом.
Не следует принимать Пантопразол-Акрихин в целях профилактики.
Не требуется коррекции дозы у пожилых пациентов и пациентов с почечной или печеночной недостаточностью.
для дозировки 40 мг:
Пантопразол-Акрихин принимают внутрь, до еды, не разжевывая и не измельчая, запивая достаточным количеством жидкости.
Язвенная болезнь желудка и двенадцатиперстной кишки, эрозивный гастрит (в том числе, связанные с приемом нестероидных противовоспалительных препаратов НПВП)
По 40-80 мг в сутки.
Курс лечения - 2 недели при обострении язвенной болезни двенадцатиперстной кишки, если этого времени недостаточно, то заживление обычно может быть достигнуто в течение последующих 2-х недель терапии. Курс лечения 4-8 недель при обострении язвенной болезни желудка и эрозивном гастрите.
Эрадикация Helicobacter pylori
Рекомендованы следующие комбинации:
1. Пантопразол-Акрихин по 40 мг 2 раза в сутки + амоксициллин по 1000 мг 2 раза в сутки + кларитромицин по 500 мг 2 раза в сутки
2. Пантопразол-Акрихин по 40 мг 2 раза в сутки + метронидазол по 500 мг 2 раза в сутки + кларитромицин по 500 мг 2 раза в сутки
3. Пантопразол-Акрихин по 40 мг 2 раза в сутки + амоксициллин по 1000 мг 2 раза в сутки + метронидазол по 500 мг 2 раза в сутки.
Курс лечения - 7-14 дней.
Синдром Золлингера-Эллисона
Для длительного лечения синдрома Золлингера-Эллисона и других патологических гиперсекреторных состояний, лечение следует начинать с суточной дозы 80 мг (2 таблетки Пантопразол-Акрихин по 40 мг). Затем, при необходимости, дозу можно повышать или уменьшать, в зависимости от показателей кислотности желудочного сока.
Дозы выше 80 мг в день следует разделять и применять два раза в день. Возможно временное повышение дозы пантопразола выше 160 мг, но оно не должно продолжаться дольше, чем это требуется для достижения контроля кислотности.
Продолжительность лечения при синдроме Золлингера-Эллисона и при других патологических гиперсекреторных состояниях не ограничена, и сроки терапии могут определяться в зависимости от клинической необходимости.
У пациентов с выраженными нарушениями функции печени суточная доза пантопразола не должна превышать 20 мг в сутки (1 таблетка пантопразола 20 мг). В связи с этим, применение пантопразола в дозировке 40 мг у данной группы пациентов не рекомендуется. Следует регулярно контролировать уровень печеночных ферментов во время лечения пантопразолом, особенно при длительном применении препарата. В случае повышения уровня печеночных ферментов лечение следует прекратить.
Не требуется коррекции дозы у пожилых пациентов и пациентов с почечной недостаточностью.
В связи с отсутствием данных о применении препарата Пантопразол-Акрихин в составе комбинированной антимикробной терапии в отношении Helicobacter pylori у пациентов с нарушением функции почек, а также у пациентов со средней и тяжелой степенью печеночной недостаточности, препарат применять не следует.
Полная инструкция
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Пантопразол-Акрихин таб. п/о кш/раств.
Пантопразол-Акрихин таб. п/о кш/раств., 20 мг, 30 шт.
3.0
(1)
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Инструкция

Цена с картой Яндекс Пэй:371 ₽

Скидка: 2%
–2 %
Вместо: 379 ₽
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3.0
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У продавца:1 оценка·1 отзыв
У всех продавцов:25 оценок·12 отзывов
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user avatar
4 дня назад • Евгений Колмычек • Куплен на Маркете
Недостатки: не подходит персонально
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    Таблетница - брелок на день, 1 раздел, контейнер для таблеток металлический маленький (черный матовый)

    Цена 209 ₽ вместо 599
  • Таблетница органайзер на неделю, контейнер для таблеток, бокс, на 7 дней, 4 приема, 28 ячеек
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    Таблетница органайзер на неделю, контейнер для таблеток, бокс, на 7 дней, 4 приема, 28 ячеек

    Цена 361 ₽ вместо 690
  • Таблетница на день 3 ячейки Oxitab синяя
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    Таблетница на день 3 ячейки Oxitab синяя

    Цена 241 ₽ вместо 520
  • Гепатрин капс., 120 шт.
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    Гепатрин капс., 120 шт.

    Цена 886 ₽ вместо 1 000
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 4 приема Clear Daswerk

    Цена 400 ₽ вместо 637
  • Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)
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    Таблетница компактная /органайзер аптечка/ контейнер для таблеток БАД Panda_Home (синего цвета)

    Цена 245 ₽ вместо 263
  • Стоп-Изжокс таб. жев., 15 шт., малина, 1 уп.
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    Стоп-Изжокс таб. жев., 15 шт., малина, 1 уп.

    Цена 176 ₽ вместо 178
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    Реклама
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  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
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    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Цена 812 ₽ вместо 1 039
  • VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер
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    VETTA / Таблетница-органайзер для таблеток аптечка для лекарств карманная в дорогу с разделителем на 14 секций, на неделю 7 дней, утро вечер

    Цена 350 ₽ вместо 950
  • Фитолакс таб. жев., 20 шт., абрикос, 1 уп.
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    Фитолакс таб. жев., 20 шт., абрикос, 1 уп.

    Цена 350 ₽ вместо 358
  • Таблетница на день / контейнер для лекарств
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    Таблетница на день / контейнер для лекарств

    Цена 494 ₽ вместо 999
  • Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка
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    Таблетница органайзер на неделю утро / день / вечер; Органайзер для таблеток на 7 дней; Карманная аптечка

    Цена 781 ₽ вместо 1 890
  • ГепатоЛИПИНТ капс., 60 шт.
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    ГепатоЛИПИНТ капс., 60 шт.

    Цена 583 ₽ вместо 1 190
  • Липроксол форте капс., 0.6 г, 90 шт., нейтральный, 1 уп.
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    Липроксол форте капс., 0.6 г, 90 шт., нейтральный, 1 уп.

    Цена 2 058 ₽ вместо 2 700
  • Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней
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    Таблетница пенал - органайзер ABORNS на неделю 7 ячеек 7 дней

    Цена 176 ₽ вместо 400
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 1 752 ₽ вместо 3 500
  • California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.
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    California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.

    Цена 1 103 ₽ вместо 1 581
  • Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.
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    Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.

    Цена 569 ₽ вместо 616
  • Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 1 прием Компактный, Daswerk
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    Таблетница на 7 дней / органайзер / бокс / контейнер на неделю для хранения таблеток и лекарств 1 прием Компактный, Daswerk

    Цена 127 ₽ вместо 181
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  • Закофальк NMX таб., 30 шт., нейтральный
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    Закофальк NMX таб., 30 шт., нейтральный

    Цена 1 104 ₽ вместо 1 115
  • Таблетница
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    Таблетница

    Цена 198 ₽ вместо 250
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