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Описание

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Рабепразол-СЗ капс. кш/раств., 10 мг, 28 шт.

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У продавца: 
нет • На Маркете: 4.8
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Коротко о товаре

Артикул Маркета
2228066510
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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118 мг, 236 мг\u003Cbr\u003Eв пересчете на рабепразол натрия - 10 мг, 20 мг\u003Cbr\u003E[ядро пеллет: Рабепразол натрия - 10,00 мг, 20,00 мг, сахарная крупка (сахароза, патока крахмальная) - 71,47 мг, 142,94 мг, натрия карбонат - 1,65 мг, 3,30 мг, тальк - 1,77 мг, 3,54 мг, титана диоксид - 0,83 мг, 1,66 мг, гипромеллоза (гидроксиметилцеллюлоза) - 14,75 мг, 29,50 мг;\u003Cbr\u003Eоболочка пеллет: гипромеллозы фталат (гидроксипропилметилфталатцеллюлоза)- 15,93 мг, 31,86 мг, цетиловый спирт - 1,60 мг, 3,20 мг].\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003EКапсулы твердые желатиновые № 3 (дозировка 10 мг):\u003Cbr\u003Eкорпус: титана диоксид - 2,0%, желатин - до 100%;\u003Cbr\u003Eкрышечка: краситель азорубин (краситель кармазин) - 0,6619%, индигокармин - 0,0286%, титана диоксид - 0,6666%, желатин - до 100%.\u003Cbr\u003EКапсулы твердые желатиновые № 1 (дозировка 20 мг):\u003Cbr\u003Eкорпус: титана диоксид - 1,0%, железа оксид желтый - 0,192% желатин - до 100%;\u003Cbr\u003Eкрышечка: железа оксид черный - 0,53%, железа оксид красный - 0,93%, титана диоксид - 0,3333%, железа оксид желтый - 0,20%, желатин - до 100%."},{"name":"Действующее вещество","value":"Рабепразол","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28709641"]}}},{"name":"Способ применения и дозы","value":"Внутрь, в дозе 10 мг один раз в сутки.\nКапсулы препарата Рабепразол-СЗ следует глотать целиком. Рекомендуется прием препарата утром, перед приемом пищи. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола натрия, но рекомендуемое время приема капсул Рабепразол-СЗ способствует лучшему соблюдению пациентами схемы лечения.\nПри отсутствии эффекта в течение первых трех дней лечения необходим осмотр специалиста. Максимальный курс лечения без консультации врача - 14 дней."},{"name":"Побочные действия","value":"Исходя из опыта клинических исследований, можно сделать вывод, что препарат Рабепразол-СЗ обычно хорошо переносится пациентами. Побочные эффекты, в целом слабо выраженные или умеренные, носят преходящий характер.\u003Cbr\u003E\nВ ходе клинических исследований отмечались следующие побочные реакции при приеме рабепразола: головная боль, боль в животе, диарея, метеоризм, запор, сухость во рту, головокружение, сыпь, периферический отек.\u003Cbr\u003E\nНарушения со стороны крови и лимфатической системы: редко - тромбоцитопения, нейтропения, лейкопения;\u003Cbr\u003E\nНарушения со стороны иммунной системы: редко - острые системные\u003Cbr\u003E\nаллергические реакции;\u003Cbr\u003E\nНарушения со стороны обмена веществ и питания: редко - гипомагниемия;\u003Cbr\u003E\nНарушения со стороны печени и желчевыводящих путей: повышение\u003Cbr\u003E\nактивности печеночных ферментов, редко - гепатит, желтуха, печеночная энцефалопатия;\u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей: редко - буллезные высыпания, крапивница; очень редко - мультиформная эритема, токсический эпидермальный некролиз, синдром Стивенса-Джонсона;\u003Cbr\u003E\nНарушения со стороны скелетно-мышечной и соединительной ткани: редко - миалгия, артралгия;\u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей: очень редко - интерстициальный нефрит;\u003Cbr\u003E\nНарушения со стороны половых органов и молочной железы: очень редко -\u003Cbr\u003E\nгинекомастия.\u003Cbr\u003E\nИзменений других лабораторных показателей в ходе приема рабепразола натрия не наблюдалось.\u003Cbr\u003E\nСогласно данным постмаркетинговых наблюдений при приеме ингибиторов протонной помпы (ИПП) возможно увеличение риска возникновения переломов, подострой кожной красной волчанки и железистых полипов дна желудка (см. раздел «Особые указания»). Редкие сообщения о печеночной энцефалопатии были получены у пациентов с циррозом."},{"name":"Фармакологическое действие","value":"Рабепразол натрия относится к классу антисекреторных веществ, производных бензимидазола. Подавляет секрецию желудочного сока путем специфического ингибирования Н+/К+-АТФ-азы на секреторной поверхности париетальных клеток желудка. Н+/К+-АТФ-аза представляет собой белковый комплекс, который функционирует, как протонная помпа, таким образом, рабепразол натрия является ингибитором протонной помпы в желудке и блокирует финальную стадию продукции кислоты. Данный эффект является дозозависимым и приводит к подавлению как базальной, так и стимулированной секреции кислоты независимо от раздражителя. Рабепразол натрия не обладает антихолинергическими свойствами.\u003Cbr\u003E\nАнтисекреторное действие\u003Cbr\u003E\nПосле перорального приема 20 мг рабепразола натрия антисекреторный эффект развивается в течение часа. Ингибирование базальной и стимулируемой секреции кислоты через 23 часа после приема первой дозы рабепразола натрия составляет 69 % и 82 % соответственно и продолжается до 48 часов. Такая продолжительность фармакодинамического действия намного превышает предсказуемое по периоду полувыведения (примерно один час). Данный эффект может быть объяснен продолжительным связыванием лекарственного вещества с Н+/К+-АТФ-азой париетальных клеток желудка. Величина ингибирующего действия рабепразола натрия на секрецию кислоты достигает плато после трех дней приема рабепразола натрия. При прекращении приема, секреторная активность восстанавливается в течение 1-2 дней.\u003Cbr\u003E\nВлияние на уровень гастрина в плазме\u003Cbr\u003E\nВ ходе клинических исследований пациенты принимали 10 или 20 мг рабепразола натрия ежедневно при продолжительности лечения до 43 месяцев. Уровень гастрина в плазме был повышен первые 2-8 недель, что отражает ингибирующее действие на секрецию кислоты. Концентрация гастрина возвращалась к исходному уровню обычно в течение 1-2 недель после прекращения лечения.\u003Cbr\u003E\nВлияние на энтерохромафинно-подобные клетки\u003Cbr\u003E\nПри исследовании образцов биопсии желудка человека из области антрума и дна желудка 500 пациентов, получавших рабепразол натрия или препарат сравнения в течение 8 недель, устойчивые изменения в морфологической структуре энтерохромафинно-подобных клеток, степени выраженности гастрита, частоте атрофического гастрита, кишечной метаплазии или распространении инфекции Helicobacter pylori не были обнаружены.\u003Cbr\u003E\nВ исследовании с участием более 400 пациентов, получавших рабепразол натрия (10 мг/день или 20 мг/день) продолжительностью до 1 года, частота гиперплазии была низкой и сравнимой с таковой для омепразола (20 мг/кг).\u003Cbr\u003E\nНе был зарегистрирован ни один случай аденоматозных изменений или карциноидных опухолей, наблюдавшихся у крыс.\u003Cbr\u003E\nДругие эффекты\u003Cbr\u003E\nСистемные эффекты рабепразола натрия в отношении центральной нервной системы, сердечно-сосудистой или дыхательной систем в настоящий момент не обнаружены. Было показано, что рабепразол натрия при пероральном приеме в дозе 20 мг в течение 2 недель не оказывает влияние на функцию щитовидной железы, углеводный обмен, уровень паратиреоидного гормона в крови, а также на уровень кортизола, эстрогенов, тестостерона, пролактина, глюкагона, фолликулостимулирующего гормона (ФСГ), лютеинизирующего гормона (ЛГ), ренина, альдостерона и соматотропного гормона."},{"name":"Фармакологическая группа","value":"ингибиторы протонного насоса"},{"name":"Форма выпуска","value":"капсулы кишечнорастворимые"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"В сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EДанные о намеренной или случайной передозировке минимальны.\u003Cbr\u003EЛечение\u003Cbr\u003EСпецифический антидот для рабепразола неизвестен. Рабепразол хорошо связывается с белками плазмы, и поэтому слабо выводится при диализе. При передозировке необходимо проводить симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Данных по безопасности применения рабепразола во время беременности нет.\u003Cbr\u003EИсследования репродуктивности на крысах и кроликах не выявили признаков нарушения фертильности или дефектов развития плода, обусловленных рабепразолом; однако у крыс в небольших количествах препарат проникает через плацентарный барьер. Рабепразол не следует применять при беременности.\u003Cbr\u003EНеизвестно, выделяется ли рабепразол с грудным молоком. Соответствующие исследования по применению препарата в период грудного вскармливания не проводились. Вместе с тем рабепразол обнаружен в молоке лактирующих крыс, и поэтому Рабепразол нельзя применять женщинам в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исходя из особенностей фармакодинамики рабепразола и его профиля нежелательных эффектов, маловероятно, что Рабепразол-СЗ оказывает влияние на способность к вождению автотранспорта и управлению механизмами. Однако в случае появления сонливости следует избегать этих видов деятельности."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003E\n- тяжелая почечная недостаточность;\u003Cbr\u003E\n- тяжелая печеночная недостаточность.\u003Cbr\u003E\nОсобые указания:\u003Cbr\u003E\nОтвет пациента на терапию рабепразолом не исключает наличие злокачественных новообразований в желудке.\u003Cbr\u003E\nКапсулы препарата Рабепразол-СЗ следует глотать целиком. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола натрия.\u003Cbr\u003E\nВ специальном исследовании у пациентов с легкими или умеренными нарушениями функции печени не было обнаружено значимого отличия частоты побочных эффектов рабепразола натрия от таковой у подобранных по полу и возрасту здоровых лиц, но, несмотря на это, рекомендуется соблюдать осторожность при первом назначении препарата Рабепразол-СЗ пациентам с тяжелыми нарушениями функции печени. AUC рабепразола натрия у пациентов с тяжелым нарушением функции печени примерно в два раза выше, чем у здоровых пациентов.\u003Cbr\u003E\nПациентам с нарушениями функции почек или печени корректировка дозы препарата Рабепразол-СЗ не требуется.\u003Cbr\u003E\nГипомагниемия\u003Cbr\u003E\nПри лечении ИПП на протяжении по крайней мере 3 месяцев в редких случаях были отмечены случаи симптоматической или асимптоматической гипомагниемии. В большинстве случаев эти сообщения поступали через год после проведения терапии. Серьезными побочными явлениями были тетания, аритмия и судороги. Большинству пациентов требовалось лечение гипомагниемии, включающей замещение магния и отмены терапии ИПП. У пациентов, которые будут получать длительное лечение или которые принимают ИПП с препаратами, такими как дигоксин или препаратами, которые могут вызвать гипомагниемию (например, диуретики), медицинские работники должны контролировать содержание магния до начала лечения ИПП и в период лечения.\u003Cbr\u003E\nПациенты не должны принимать одновременно с препаратом Рабепразол-СЗ другие средства, снижающие кислотность, например блокаторы Н2- рецепторов или ингибиторы протонной помпы.\u003Cbr\u003E\nПереломы костей\u003Cbr\u003E\nСогласно данным наблюдательных исследований можно предположить, что терапия ингибиторами протонной помпы (ИПП) может привести к возрастанию риска связанных с остеопорозом переломов бедра, запястья или позвоночника. Риск переломов был увеличен у пациентов, получавших высокие дозы ИПП длительно (год и более).\u003Cbr\u003E\nОдновременное применение рабепразола с метотрексатом\u003Cbr\u003E\nСогласно литературным данным, одновременный прием ИПП с метотрексатом (прежде всего в высоких дозах) может привести к повышению концентрации метотрексата и/или его метаболита С гидроксиметотрексата и увеличить период полувыведения, что может привести к проявлению токсичности метотрексата. При необходимости применения высоких доз метотрексата, может быть рассмотрена возможность временного прекращения терапии ИПП.\u003Cbr\u003E\nClostridium difficile.\u003Cbr\u003E\nТерапия ИПП может приводить к возрастанию риска желудочно-кишечных инфекций, таких как Clostridium difficile.\u003Cbr\u003E\nПодострая кожная красная волчанка (ПККВ)\u003Cbr\u003E\nИмеются сообщения о случаях ПККВ при терапии ИПП. Если поражения кожи появляются, особенно на участках кожи, подвергшихся воздействию прямых солнечных лучей, и сопровождаются артралгией, пациенту необходимо немедленно обратиться за медицинской помощью, медицинский работник должен принять решение о прекращении терапии рабепразолом. Возникновение ПККВ при предыдущей терапии ИПП может увеличить риск возникновения ПККВ при приеме других ИПП.\u003Cbr\u003E\nЖелезистые полипы дня желудка\u003Cbr\u003E\nДлительное использование ИПП, включая рабепразол, по всей видимости, связано с повышенным риском возникновения железистых полипов дна желудка. Большинство железистых полипов дна желудка бессимптомны. Пациенты с крупными или изъязвленными полипами могут подвергаться риску желудочно-кишечных кровотечений или тонкокишечной непроходимости. Дозировка и продолжительность терапии ИПП для таких пациентов должны быть минимальными.\u003Cbr\u003E\nПациентам, принимающим препарат Рабепразол-СЗ для кратковременного симптоматического лечения проявлений ГЭРБ и НЭРБ (например, изжоги) без рецепта, следует обратиться к врачу в следующих случаях:\u003Cbr\u003E\n- применение средств для снятия симптомов изжоги и нарушения пищеварения в течение 4 недель и более;\u003Cbr\u003E\n- появление новых симптомов или изменение ранее наблюдавшихся симптомов у пациентов в возрасте более 55 лет;\u003Cbr\u003E\n- случаи ненамеренного уменьшения массы тела, анемии, кровотечений в желудочно-кишечном тракте, дисфагии, боли при глотании, постоянной рвоты или рвоты с кровью и содержимым эпигастрия, случаи язвы желудка или операций на желудке в анамнезе, желтухи и т.д. (в т.ч. нарушение функции печени и почек).\u003Cbr\u003E\nПациенты, длительное время страдающие от повторяющихся симптомов нарушения пищеварения или изжоги, должны регулярно наблюдаться у врача. Пациенты в возрасте более 55 лет, ежедневно принимающие безрецептурные препараты для снятия симптомов изжоги и нарушения пищеварения, должны проинформировать об этом своего лечащего врача.\u003Cbr\u003E\nПациенты не должны принимать одновременно с препаратом Рабепразол-СЗ другие средства, снижающие кислотность, например блокаторы Н2-рецепторов или ингибиторы протонной помпы.\u003Cbr\u003E\nПри применении других препаратов пациентам следует проконсультироваться с фармацевтом или лечащим врачом перед началом терапии препаратом Рабепразол-СЗ, отпускаемым без рецепта.\u003Cbr\u003E\nПациенты должны сообщить врачу перед началом применения препарата Рабепразол-СЗ без рецепта, если им назначено эндоскопическое исследование.\u003Cbr\u003E\nСледует избегать прием препарата Рабепразол-СЗ перед проведением мочевинного дыхательного теста.\u003Cbr\u003E\nПациенты с тяжелыми нарушениями функции печени должны обратиться к врачу перед началом терапии препаратом Рабепразол-СЗ, отпускаемым без рецепта, для кратковременного симптоматического лечения проявлений ГЭРБ и НЭРБ (например, изжоги)."},{"name":"Взаимодействие","value":"Система цитохрома 450\u003Cbr\u003E\nРабепразол натрия, как и другие ингибиторы протонной помпы (ИПП), метаболизируется с участием системы цитохрома Р450 (СYР450) в печени. В исследованиях in vitro на микросомах печени человека было показано, что рабепразол натрия метаболизируется изоферментами СYР2С19 и СYР3А4.\u003Cbr\u003E\nИсследования на здоровых добровольцах показали, что рабепразол натрия не имеет фармакокинетических или клинически значимых взаимодействий с лекарственными веществами, которые метаболизируются системой цитохрома Р450 - варфарином, фенитоином, теофиллином и диазепамом (независимо от того, метаболизируют ли пациенты диазепам усиленно или слабо).\u003Cbr\u003E\nБыло проведено исследование комбинированной терапии с антибактериальными препаратами. В данном четырехстороннем перекрестном исследовании участвовали 16 здоровых добровольцев, которые получали 20 мг рабепразола, 1000 мг амоксициллина, 500 мг кларитромицина или комбинацию этих трех препаратов (РАК - рабепразол, амоксициллин, кларитромицин). Показатели AUC и Сmах для кларитромицина и амоксициллина были схожими при сравнении комбинированной терапии с монотерапией. Показатели AUC и Сmах для рабепразола увеличились на 11 % и 34 % соответственно, а для 14-гидроксикларитромицина (активного метаболита кларитромицина) AUC и Сmах увеличились на 42 % и 46 % соответственно для комбинированной терапии в сравнении с монотерапией. Данное увеличение показателей воздействия для рабепразола и кларитромицина не было признано клинически значимым.\u003Cbr\u003E\nВзаимодействия вследствие ингибирования секреции желудочного сока\u003Cbr\u003E\nРабепразол натрия осуществляет устойчивое и продолжительное подавление секреции желудочного сока. Таким образом, может происходить взаимодействие с веществами, для которых абсорбция зависит от рН. При одновременном приеме с рабепразолом натрия абсорбция кетоконазола уменьшается на 30 %, а абсорбция дигоксина увеличивается на 22 %. Следовательно, для некоторых пациентов должно проводиться наблюдение для решения вопроса о необходимости корректировки дозы при одновременном приеме рабепразола натрия с кетоконазолом, дигоксином или другими лекарственными препаратами, для которых абсорбция зависит от рН.\u003Cbr\u003E\nАтазанавир\u003Cbr\u003E\nПри одновременном приеме атазанавира 300 мг/ритонавира 100 мг с омепразолом (40 мг 1 раз в день) или атазанавира 400 мг с лансопразолом (60 мг 1 раз в день) здоровыми добровольцами наблюдалось существенное снижение воздействия атазанавира. Абсорбция атазанавира зависит от рН. Хотя одновременный прием с рабепразолом не изучался, схожие результаты ожидаются также для других ингибиторов протонного насоса. Таким образом, не рекомендуется одновременный прием атазанавира с ингибиторами протонного насоса, включая рабепразол.\u003Cbr\u003E\nАнтацидные средства\u003Cbr\u003E\nВ клинических исследованиях антацидные вещества применялись совместно с рабепразолом натрия. Клинически значимые взаимодействия рабепразола натрия с гелем гидроксида алюминия или с гидроксидом магния не наблюдались.\u003Cbr\u003E\nПрием пищи\u003Cbr\u003E\nВ клиническом исследовании в ходе приема рабепразола натрия с обедненной жирами пищи клинически значимых взаимодействий не наблюдалось. Прием рабепразола натрия одновременно с обогащенной жирами пищей может замедлить всасывание рабепразола до 4 часов и более, однако, Сmах и AUC не изменяются.\u003Cbr\u003E\nЦиклоспорин\u003Cbr\u003E\nЭксперименты in vitro с использованием микросом печени человека показали, что рабепразол ингибирует метаболизм циклоспорина с IC50 62 мкмоль, т.е. в концентрации, в 50 раз превышающей Сmах для здоровых добровольцев после 14 дней приема 20 мг рабепразола. Степень ингибирования схожа с таковой для омепразола для эквивалентных концентраций.\u003Cbr\u003E\nМетотрексат\u003Cbr\u003E\nСогласно данным сообщений о нежелательных явлениях, данным опубликованных фармакокинетических исследований и данным ретроспективного анализа можно предположить, что одновременный прием ИПП и метотрексата (прежде всего в высоких дозах) может привести к повышению концентрации метотрексата и/или его метаболита гидроксиметотрексата и увеличить период полувыведения. Тем не менее специальных исследований лекарственного взаимодействия метотрексата с ИПП не проводилось.\u003Cbr\u003E\nВлияние на результаты лабораторных исследований\u003Cbr\u003E\nПрименение ИПП приводит к снижению кислотности желудочного сока, что может привести к увеличению содержания хромогранина А (CgA) в сыворотке крови. Повышенный уровень CgA может привести к ошибочной интерпретации результатов лабораторных исследований на наличие нейроэндокринной опухоли. Во избежание этого влияния применение препарата Рабепразол-СЗ должно быть временно прекращено, по крайней мере за 14 дней до оценки уровня CgA; повторение теста следует рассмотреть в случае, если исходный уровень CgA является высоким."},{"name":"Регистрационный номер","value":"ЛП-003466"},{"name":"Дата государственной регистрации","value":"18.02.2021"},{"name":"Владелец регистрационного удостоверения","value":"Северная Звезда","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:16002862"]}}},{"name":"Изготовитель","value":"Северная Звезда"},{"name":"Фасовщик","value":"Северная Звезда"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Рабепразол","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18008599"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"808835634883279253":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"желудочно-кишечный тракт, пищеварительная система"},{"name":"Назначение","value":"гастроэзофагиальный рефлюкс, диспепсические явления, язвенная болезнь желудка и двенадцатиперстной кишки"},{"name":"Показания к применению","value":"Симптомы диспепсии, связанной с повышенной кислотностью желудочного сока, в т.ч. симптомы гастроэзофагеальной рефлюксной болезни (изжога, кислая отрыжка)."},{"name":"Противопоказания","value":"- гиперчувствительность к рабепразолу, замещенным бензимидазолам или к вспомогательным компонентам препарата;\u003Cbr\u003E\n- дефицит сахаразы/изомальтазы, непереносимость фруктозы, глюкозо-галактозная недостаточность;\u003Cbr\u003E\n- беременность;\u003Cbr\u003E\n- период грудного вскармливания;\u003Cbr\u003E\n- детский возраст до 18 лет."},{"name":"Состав","value":"1 капсула содержит:\u003Cbr\u003EАктивного вещества:\u003Cbr\u003Eрабепразол пеллеты - 118 мг, 236 мг\u003Cbr\u003Eв пересчете на рабепразол натрия - 10 мг, 20 мг\u003Cbr\u003E[ядро пеллет: Рабепразол натрия - 10,00 мг, 20,00 мг, сахарная крупка (сахароза, патока крахмальная) - 71,47 мг, 142,94 мг, натрия карбонат - 1,65 мг, 3,30 мг, тальк - 1,77 мг, 3,54 мг, титана диоксид - 0,83 мг, 1,66 мг, гипромеллоза (гидроксиметилцеллюлоза) - 14,75 мг, 29,50 мг;\u003Cbr\u003Eоболочка пеллет: гипромеллозы фталат (гидроксипропилметилфталатцеллюлоза)- 15,93 мг, 31,86 мг, цетиловый спирт - 1,60 мг, 3,20 мг].\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003EКапсулы твердые желатиновые № 3 (дозировка 10 мг):\u003Cbr\u003Eкорпус: титана диоксид - 2,0%, желатин - до 100%;\u003Cbr\u003Eкрышечка: краситель азорубин (краситель кармазин) - 0,6619%, индигокармин - 0,0286%, титана диоксид - 0,6666%, желатин - до 100%.\u003Cbr\u003EКапсулы твердые желатиновые № 1 (дозировка 20 мг):\u003Cbr\u003Eкорпус: титана диоксид - 1,0%, железа оксид желтый - 0,192% желатин - до 100%;\u003Cbr\u003Eкрышечка: железа оксид черный - 0,53%, железа оксид красный - 0,93%, титана диоксид - 0,3333%, железа оксид желтый - 0,20%, желатин - до 100%."},{"name":"Действующее вещество","value":"Рабепразол"},{"name":"Способ применения и дозы","value":"Внутрь, в дозе 10 мг один раз в сутки.\nКапсулы препарата Рабепразол-СЗ следует глотать целиком. Рекомендуется прием препарата утром, перед приемом пищи. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола натрия, но рекомендуемое время приема капсул Рабепразол-СЗ способствует лучшему соблюдению пациентами схемы лечения.\nПри отсутствии эффекта в течение первых трех дней лечения необходим осмотр специалиста. Максимальный курс лечения без консультации врача - 14 дней."},{"name":"Побочные действия","value":"Исходя из опыта клинических исследований, можно сделать вывод, что препарат Рабепразол-СЗ обычно хорошо переносится пациентами. Побочные эффекты, в целом слабо выраженные или умеренные, носят преходящий характер.\u003Cbr\u003E\nВ ходе клинических исследований отмечались следующие побочные реакции при приеме рабепразола: головная боль, боль в животе, диарея, метеоризм, запор, сухость во рту, головокружение, сыпь, периферический отек.\u003Cbr\u003E\nНарушения со стороны крови и лимфатической системы: редко - тромбоцитопения, нейтропения, лейкопения;\u003Cbr\u003E\nНарушения со стороны иммунной системы: редко - острые системные\u003Cbr\u003E\nаллергические реакции;\u003Cbr\u003E\nНарушения со стороны обмена веществ и питания: редко - гипомагниемия;\u003Cbr\u003E\nНарушения со стороны печени и желчевыводящих путей: повышение\u003Cbr\u003E\nактивности печеночных ферментов, редко - гепатит, желтуха, печеночная энцефалопатия;\u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей: редко - буллезные высыпания, крапивница; очень редко - мультиформная эритема, токсический эпидермальный некролиз, синдром Стивенса-Джонсона;\u003Cbr\u003E\nНарушения со стороны скелетно-мышечной и соединительной ткани: редко - миалгия, артралгия;\u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей: очень редко - интерстициальный нефрит;\u003Cbr\u003E\nНарушения со стороны половых органов и молочной железы: очень редко -\u003Cbr\u003E\nгинекомастия.\u003Cbr\u003E\nИзменений других лабораторных показателей в ходе приема рабепразола натрия не наблюдалось.\u003Cbr\u003E\nСогласно данным постмаркетинговых наблюдений при приеме ингибиторов протонной помпы (ИПП) возможно увеличение риска возникновения переломов, подострой кожной красной волчанки и железистых полипов дна желудка (см. раздел «Особые указания»). Редкие сообщения о печеночной энцефалопатии были получены у пациентов с циррозом."},{"name":"Фармакологическое действие","value":"Рабепразол натрия относится к классу антисекреторных веществ, производных бензимидазола. Подавляет секрецию желудочного сока путем специфического ингибирования Н+/К+-АТФ-азы на секреторной поверхности париетальных клеток желудка. Н+/К+-АТФ-аза представляет собой белковый комплекс, который функционирует, как протонная помпа, таким образом, рабепразол натрия является ингибитором протонной помпы в желудке и блокирует финальную стадию продукции кислоты. Данный эффект является дозозависимым и приводит к подавлению как базальной, так и стимулированной секреции кислоты независимо от раздражителя. Рабепразол натрия не обладает антихолинергическими свойствами.\u003Cbr\u003E\nАнтисекреторное действие\u003Cbr\u003E\nПосле перорального приема 20 мг рабепразола натрия антисекреторный эффект развивается в течение часа. Ингибирование базальной и стимулируемой секреции кислоты через 23 часа после приема первой дозы рабепразола натрия составляет 69 % и 82 % соответственно и продолжается до 48 часов. Такая продолжительность фармакодинамического действия намного превышает предсказуемое по периоду полувыведения (примерно один час). Данный эффект может быть объяснен продолжительным связыванием лекарственного вещества с Н+/К+-АТФ-азой париетальных клеток желудка. Величина ингибирующего действия рабепразола натрия на секрецию кислоты достигает плато после трех дней приема рабепразола натрия. При прекращении приема, секреторная активность восстанавливается в течение 1-2 дней.\u003Cbr\u003E\nВлияние на уровень гастрина в плазме\u003Cbr\u003E\nВ ходе клинических исследований пациенты принимали 10 или 20 мг рабепразола натрия ежедневно при продолжительности лечения до 43 месяцев. Уровень гастрина в плазме был повышен первые 2-8 недель, что отражает ингибирующее действие на секрецию кислоты. Концентрация гастрина возвращалась к исходному уровню обычно в течение 1-2 недель после прекращения лечения.\u003Cbr\u003E\nВлияние на энтерохромафинно-подобные клетки\u003Cbr\u003E\nПри исследовании образцов биопсии желудка человека из области антрума и дна желудка 500 пациентов, получавших рабепразол натрия или препарат сравнения в течение 8 недель, устойчивые изменения в морфологической структуре энтерохромафинно-подобных клеток, степени выраженности гастрита, частоте атрофического гастрита, кишечной метаплазии или распространении инфекции Helicobacter pylori не были обнаружены.\u003Cbr\u003E\nВ исследовании с участием более 400 пациентов, получавших рабепразол натрия (10 мг/день или 20 мг/день) продолжительностью до 1 года, частота гиперплазии была низкой и сравнимой с таковой для омепразола (20 мг/кг).\u003Cbr\u003E\nНе был зарегистрирован ни один случай аденоматозных изменений или карциноидных опухолей, наблюдавшихся у крыс.\u003Cbr\u003E\nДругие эффекты\u003Cbr\u003E\nСистемные эффекты рабепразола натрия в отношении центральной нервной системы, сердечно-сосудистой или дыхательной систем в настоящий момент не обнаружены. Было показано, что рабепразол натрия при пероральном приеме в дозе 20 мг в течение 2 недель не оказывает влияние на функцию щитовидной железы, углеводный обмен, уровень паратиреоидного гормона в крови, а также на уровень кортизола, эстрогенов, тестостерона, пролактина, глюкагона, фолликулостимулирующего гормона (ФСГ), лютеинизирующего гормона (ЛГ), ренина, альдостерона и соматотропного гормона."},{"name":"Фармакологическая группа","value":"ингибиторы протонного насоса"},{"name":"Форма выпуска","value":"капсулы кишечнорастворимые"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В сухом, защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EДанные о намеренной или случайной передозировке минимальны.\u003Cbr\u003EЛечение\u003Cbr\u003EСпецифический антидот для рабепразола неизвестен. Рабепразол хорошо связывается с белками плазмы, и поэтому слабо выводится при диализе. При передозировке необходимо проводить симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Данных по безопасности применения рабепразола во время беременности нет.\u003Cbr\u003EИсследования репродуктивности на крысах и кроликах не выявили признаков нарушения фертильности или дефектов развития плода, обусловленных рабепразолом; однако у крыс в небольших количествах препарат проникает через плацентарный барьер. Рабепразол не следует применять при беременности.\u003Cbr\u003EНеизвестно, выделяется ли рабепразол с грудным молоком. Соответствующие исследования по применению препарата в период грудного вскармливания не проводились. Вместе с тем рабепразол обнаружен в молоке лактирующих крыс, и поэтому Рабепразол нельзя применять женщинам в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исходя из особенностей фармакодинамики рабепразола и его профиля нежелательных эффектов, маловероятно, что Рабепразол-СЗ оказывает влияние на способность к вождению автотранспорта и управлению механизмами. Однако в случае появления сонливости следует избегать этих видов деятельности."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003E\n- тяжелая почечная недостаточность;\u003Cbr\u003E\n- тяжелая печеночная недостаточность.\u003Cbr\u003E\nОсобые указания:\u003Cbr\u003E\nОтвет пациента на терапию рабепразолом не исключает наличие злокачественных новообразований в желудке.\u003Cbr\u003E\nКапсулы препарата Рабепразол-СЗ следует глотать целиком. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола натрия.\u003Cbr\u003E\nВ специальном исследовании у пациентов с легкими или умеренными нарушениями функции печени не было обнаружено значимого отличия частоты побочных эффектов рабепразола натрия от таковой у подобранных по полу и возрасту здоровых лиц, но, несмотря на это, рекомендуется соблюдать осторожность при первом назначении препарата Рабепразол-СЗ пациентам с тяжелыми нарушениями функции печени. AUC рабепразола натрия у пациентов с тяжелым нарушением функции печени примерно в два раза выше, чем у здоровых пациентов.\u003Cbr\u003E\nПациентам с нарушениями функции почек или печени корректировка дозы препарата Рабепразол-СЗ не требуется.\u003Cbr\u003E\nГипомагниемия\u003Cbr\u003E\nПри лечении ИПП на протяжении по крайней мере 3 месяцев в редких случаях были отмечены случаи симптоматической или асимптоматической гипомагниемии. В большинстве случаев эти сообщения поступали через год после проведения терапии. Серьезными побочными явлениями были тетания, аритмия и судороги. Большинству пациентов требовалось лечение гипомагниемии, включающей замещение магния и отмены терапии ИПП. У пациентов, которые будут получать длительное лечение или которые принимают ИПП с препаратами, такими как дигоксин или препаратами, которые могут вызвать гипомагниемию (например, диуретики), медицинские работники должны контролировать содержание магния до начала лечения ИПП и в период лечения.\u003Cbr\u003E\nПациенты не должны принимать одновременно с препаратом Рабепразол-СЗ другие средства, снижающие кислотность, например блокаторы Н2- рецепторов или ингибиторы протонной помпы.\u003Cbr\u003E\nПереломы костей\u003Cbr\u003E\nСогласно данным наблюдательных исследований можно предположить, что терапия ингибиторами протонной помпы (ИПП) может привести к возрастанию риска связанных с остеопорозом переломов бедра, запястья или позвоночника. Риск переломов был увеличен у пациентов, получавших высокие дозы ИПП длительно (год и более).\u003Cbr\u003E\nОдновременное применение рабепразола с метотрексатом\u003Cbr\u003E\nСогласно литературным данным, одновременный прием ИПП с метотрексатом (прежде всего в высоких дозах) может привести к повышению концентрации метотрексата и/или его метаболита С гидроксиметотрексата и увеличить период полувыведения, что может привести к проявлению токсичности метотрексата. При необходимости применения высоких доз метотрексата, может быть рассмотрена возможность временного прекращения терапии ИПП.\u003Cbr\u003E\nClostridium difficile.\u003Cbr\u003E\nТерапия ИПП может приводить к возрастанию риска желудочно-кишечных инфекций, таких как Clostridium difficile.\u003Cbr\u003E\nПодострая кожная красная волчанка (ПККВ)\u003Cbr\u003E\nИмеются сообщения о случаях ПККВ при терапии ИПП. Если поражения кожи появляются, особенно на участках кожи, подвергшихся воздействию прямых солнечных лучей, и сопровождаются артралгией, пациенту необходимо немедленно обратиться за медицинской помощью, медицинский работник должен принять решение о прекращении терапии рабепразолом. Возникновение ПККВ при предыдущей терапии ИПП может увеличить риск возникновения ПККВ при приеме других ИПП.\u003Cbr\u003E\nЖелезистые полипы дня желудка\u003Cbr\u003E\nДлительное использование ИПП, включая рабепразол, по всей видимости, связано с повышенным риском возникновения железистых полипов дна желудка. Большинство железистых полипов дна желудка бессимптомны. Пациенты с крупными или изъязвленными полипами могут подвергаться риску желудочно-кишечных кровотечений или тонкокишечной непроходимости. Дозировка и продолжительность терапии ИПП для таких пациентов должны быть минимальными.\u003Cbr\u003E\nПациентам, принимающим препарат Рабепразол-СЗ для кратковременного симптоматического лечения проявлений ГЭРБ и НЭРБ (например, изжоги) без рецепта, следует обратиться к врачу в следующих случаях:\u003Cbr\u003E\n- применение средств для снятия симптомов изжоги и нарушения пищеварения в течение 4 недель и более;\u003Cbr\u003E\n- появление новых симптомов или изменение ранее наблюдавшихся симптомов у пациентов в возрасте более 55 лет;\u003Cbr\u003E\n- случаи ненамеренного уменьшения массы тела, анемии, кровотечений в желудочно-кишечном тракте, дисфагии, боли при глотании, постоянной рвоты или рвоты с кровью и содержимым эпигастрия, случаи язвы желудка или операций на желудке в анамнезе, желтухи и т.д. (в т.ч. нарушение функции печени и почек).\u003Cbr\u003E\nПациенты, длительное время страдающие от повторяющихся симптомов нарушения пищеварения или изжоги, должны регулярно наблюдаться у врача. Пациенты в возрасте более 55 лет, ежедневно принимающие безрецептурные препараты для снятия симптомов изжоги и нарушения пищеварения, должны проинформировать об этом своего лечащего врача.\u003Cbr\u003E\nПациенты не должны принимать одновременно с препаратом Рабепразол-СЗ другие средства, снижающие кислотность, например блокаторы Н2-рецепторов или ингибиторы протонной помпы.\u003Cbr\u003E\nПри применении других препаратов пациентам следует проконсультироваться с фармацевтом или лечащим врачом перед началом терапии препаратом Рабепразол-СЗ, отпускаемым без рецепта.\u003Cbr\u003E\nПациенты должны сообщить врачу перед началом применения препарата Рабепразол-СЗ без рецепта, если им назначено эндоскопическое исследование.\u003Cbr\u003E\nСледует избегать прием препарата Рабепразол-СЗ перед проведением мочевинного дыхательного теста.\u003Cbr\u003E\nПациенты с тяжелыми нарушениями функции печени должны обратиться к врачу перед началом терапии препаратом Рабепразол-СЗ, отпускаемым без рецепта, для кратковременного симптоматического лечения проявлений ГЭРБ и НЭРБ (например, изжоги)."},{"name":"Взаимодействие","value":"Система цитохрома 450\u003Cbr\u003E\nРабепразол натрия, как и другие ингибиторы протонной помпы (ИПП), метаболизируется с участием системы цитохрома Р450 (СYР450) в печени. В исследованиях in vitro на микросомах печени человека было показано, что рабепразол натрия метаболизируется изоферментами СYР2С19 и СYР3А4.\u003Cbr\u003E\nИсследования на здоровых добровольцах показали, что рабепразол натрия не имеет фармакокинетических или клинически значимых взаимодействий с лекарственными веществами, которые метаболизируются системой цитохрома Р450 - варфарином, фенитоином, теофиллином и диазепамом (независимо от того, метаболизируют ли пациенты диазепам усиленно или слабо).\u003Cbr\u003E\nБыло проведено исследование комбинированной терапии с антибактериальными препаратами. В данном четырехстороннем перекрестном исследовании участвовали 16 здоровых добровольцев, которые получали 20 мг рабепразола, 1000 мг амоксициллина, 500 мг кларитромицина или комбинацию этих трех препаратов (РАК - рабепразол, амоксициллин, кларитромицин). Показатели AUC и Сmах для кларитромицина и амоксициллина были схожими при сравнении комбинированной терапии с монотерапией. Показатели AUC и Сmах для рабепразола увеличились на 11 % и 34 % соответственно, а для 14-гидроксикларитромицина (активного метаболита кларитромицина) AUC и Сmах увеличились на 42 % и 46 % соответственно для комбинированной терапии в сравнении с монотерапией. Данное увеличение показателей воздействия для рабепразола и кларитромицина не было признано клинически значимым.\u003Cbr\u003E\nВзаимодействия вследствие ингибирования секреции желудочного сока\u003Cbr\u003E\nРабепразол натрия осуществляет устойчивое и продолжительное подавление секреции желудочного сока. Таким образом, может происходить взаимодействие с веществами, для которых абсорбция зависит от рН. При одновременном приеме с рабепразолом натрия абсорбция кетоконазола уменьшается на 30 %, а абсорбция дигоксина увеличивается на 22 %. Следовательно, для некоторых пациентов должно проводиться наблюдение для решения вопроса о необходимости корректировки дозы при одновременном приеме рабепразола натрия с кетоконазолом, дигоксином или другими лекарственными препаратами, для которых абсорбция зависит от рН.\u003Cbr\u003E\nАтазанавир\u003Cbr\u003E\nПри одновременном приеме атазанавира 300 мг/ритонавира 100 мг с омепразолом (40 мг 1 раз в день) или атазанавира 400 мг с лансопразолом (60 мг 1 раз в день) здоровыми добровольцами наблюдалось существенное снижение воздействия атазанавира. Абсорбция атазанавира зависит от рН. Хотя одновременный прием с рабепразолом не изучался, схожие результаты ожидаются также для других ингибиторов протонного насоса. Таким образом, не рекомендуется одновременный прием атазанавира с ингибиторами протонного насоса, включая рабепразол.\u003Cbr\u003E\nАнтацидные средства\u003Cbr\u003E\nВ клинических исследованиях антацидные вещества применялись совместно с рабепразолом натрия. Клинически значимые взаимодействия рабепразола натрия с гелем гидроксида алюминия или с гидроксидом магния не наблюдались.\u003Cbr\u003E\nПрием пищи\u003Cbr\u003E\nВ клиническом исследовании в ходе приема рабепразола натрия с обедненной жирами пищи клинически значимых взаимодействий не наблюдалось. Прием рабепразола натрия одновременно с обогащенной жирами пищей может замедлить всасывание рабепразола до 4 часов и более, однако, Сmах и AUC не изменяются.\u003Cbr\u003E\nЦиклоспорин\u003Cbr\u003E\nЭксперименты in vitro с использованием микросом печени человека показали, что рабепразол ингибирует метаболизм циклоспорина с IC50 62 мкмоль, т.е. в концентрации, в 50 раз превышающей Сmах для здоровых добровольцев после 14 дней приема 20 мг рабепразола. Степень ингибирования схожа с таковой для омепразола для эквивалентных концентраций.\u003Cbr\u003E\nМетотрексат\u003Cbr\u003E\nСогласно данным сообщений о нежелательных явлениях, данным опубликованных фармакокинетических исследований и данным ретроспективного анализа можно предположить, что одновременный прием ИПП и метотрексата (прежде всего в высоких дозах) может привести к повышению концентрации метотрексата и/или его метаболита гидроксиметотрексата и увеличить период полувыведения. Тем не менее специальных исследований лекарственного взаимодействия метотрексата с ИПП не проводилось.\u003Cbr\u003E\nВлияние на результаты лабораторных исследований\u003Cbr\u003E\nПрименение ИПП приводит к снижению кислотности желудочного сока, что может привести к увеличению содержания хромогранина А (CgA) в сыворотке крови. Повышенный уровень CgA может привести к ошибочной интерпретации результатов лабораторных исследований на наличие нейроэндокринной опухоли. Во избежание этого влияния применение препарата Рабепразол-СЗ должно быть временно прекращено, по крайней мере за 14 дней до оценки уровня CgA; повторение теста следует рассмотреть в случае, если исходный уровень CgA является высоким."},{"name":"Регистрационный номер","value":"ЛП-003466"},{"name":"Дата государственной регистрации","value":"18.02.2021"},{"name":"Владелец регистрационного удостоверения","value":"Северная Звезда"},{"name":"Изготовитель","value":"Северная Звезда"},{"name":"Фасовщик","value":"Северная Звезда"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Рабепразол"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_8094337042350719885"}}}}
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Ещё может подойти

  • Альфазокс р-р д/вн прим. саше, 10 мл, 20 шт., 1 уп.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-syrfaw4gc2/toggleWishlist":{"skuId":"101422383738","productId":649931041,"offerId":"kUhs-GtA30OSl8gr3iJvNQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIodL0tQIQ+oT76fkCGOn09gcg2tnBBw==","sign":"vJQnt5FznfnlEc7USrlYwAhOX59q0JxCgs4YWbdUW9U="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-syrfaw4gc2/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Альфазокс р-р д/вн прим. саше, 10 мл, 20 шт., 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 155 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 153 ₽ вместо 1 165
    {"widgets":{"@light/AddToCartButtonSnippet":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-syrfaw4gc2/addToCartButton":{"offerId":"kUhs-GtA30OSl8gr3iJvNQ","skuId":"101422383738","pendingCartItem":{"productId":649931041,"offerId":"kUhs-GtA30OSl8gr3iJvNQ","showPlaceId":"OTNDnItfwRMjN9MRHuEMMtg-QGx4Bfwc_Wk0pmCbJ-75uAzJk__zd-APenbXYg_QD7GGPk8jrAyW5blx_TRZmYEgyIEB3anCr94AfxAJYs0OfpJrBA5BznXtjF1beniVJq8r1pZT3JUbs6KCPH0V7PoIAnQbbWLRl0aI5xC-rNNLnVUjg8wfiPQZ4ZAth5_pzP9_gFqDMdM9myaROoun6Q,,","feeShow":"OTNDnItfwRMjN9MRHuEMMtg-QGx4Bfwc_Wk0pmCbJ-75uAzJk__zd-APenbXYg_QD7GGPk8jrAyW5blx_TRZmYEgyIEB3anCr94AfxAJYs0OfpJrBA5BznXtjF1beniVJq8r1pZT3JUbs6KCPH0V7PoIAnQbbWLRl0aI5xC-rNNLnVUjg8wfiPQZ4ZAth5_pzP9_gFqDMdM9myaROoun6Q,,","skuId":"101422383738","shopId":11693184,"price":{"applicablePriceDiscounts":[{"priceWithDiscount":"1153","type":"ya-card","totalPercentWithDiscount":1}],"value":"1165","currency":"RUR"},"hid":"15756506","name":"Альфазокс р-р д/вн прим. саше, 10 мл, 20 шт., 1 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  • Гепатрин капс., 120 шт.
    –11 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-rox5thrdb4j/toggleWishlist":{"skuId":"101768642806","productId":1400799509,"offerId":"BEkmqidXLKn-dw6mRLbRjg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcIlYL6mwUQ9oGJj/sCGNW7oQYg2tnBBw==","sign":"Bpd141l7w2gxdtY4SBcDaxTPh/DiEAUF2Fm1w7+QyGw="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-rox5thrdb4j/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гепатрин капс., 120 шт.

    Рейтинг товара: 4.8 из 5
    на основе 881 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 886 ₽ вместо 895
    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  • Симетикон с фенхелем капс., 300 мг, 60 шт.
    –6 %
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    Симетикон с фенхелем капс., 300 мг, 60 шт.

    Рейтинг товара: 4.7 из 5
    на основе 418 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 822 ₽ вместо 830
    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  • Хелинорм капс., 28 шт., 1 уп.
    –2 %
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    Хелинорм капс., 28 шт., 1 уп.

    Рейтинг товара: 5 из 5
    на основе 8 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 134 ₽ вместо 2 178
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  • Овесол таб. п/о, 40 шт.
    –2 %
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    Овесол таб. п/о, 40 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 544 ₽ вместо 556
    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таб. п/о, 40 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  • Гастрарекс Нео капс., 30 шт., 1 уп.
    –31 %
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    Гастрарекс Нео капс., 30 шт., 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 183 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 011 ₽ вместо 1 021
    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  • Синбиотик Мax капс., 10 шт.
    –2 %
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    Синбиотик Мax капс., 10 шт.

    Рейтинг товара: 4.8 из 5
    на основе 135 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 273 ₽ вместо 279
    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  • Бак-сет форте капс., 20 шт., 1 уп.
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    Бак-сет форте капс., 20 шт., 1 уп.

    Цена 870 ₽
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  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
    –50 %
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 574 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 752 ₽ вместо 1 770
    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Пробиотик капли детск. фл., 5 мл, 1 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  • Бифидумбактерин-1000 таб., 30 шт., 1 уп.
    –16 %
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    Бифидумбактерин-1000 таб., 30 шт., 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 49 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 188 ₽ вместо 190
    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  • Пепидол ПЭГ для взрослых р-р д/вн. приема, 5%, 250 мл, 1 уп.
    –10 %
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    Пепидол ПЭГ для взрослых р-р д/вн. приема, 5%, 250 мл, 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 29 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 584 ₽ вместо 590
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Инструкция

Показания к применению

Симптомы диспепсии, связанной с повышенной кислотностью желудочного сока, в т.ч. симптомы гастроэзофагеальной рефлюксной болезни (изжога, кислая отрыжка).

Противопоказания

- гиперчувствительность к рабепразолу, замещенным бензимидазолам или к вспомогательным компонентам препарата;
- дефицит сахаразы/изомальтазы, непереносимость фруктозы, глюкозо-галактозная недостаточность;
- беременность;
- период грудного вскармливания;
- детский возраст до 18 лет.

Способ применения и дозы

Внутрь, в дозе 10 мг один раз в сутки. Капсулы препарата Рабепразол-СЗ следует глотать целиком. Рекомендуется прием препарата утром, перед приемом пищи. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола натрия, но рекомендуемое время приема капсул Рабепразол-СЗ способствует лучшему соблюдению пациентами схемы лечения. При отсутствии эффекта в течение первых трех дней лечения необходим осмотр специалиста. Максимальный курс лечения без консультации врача - 14 дней.
Полная инструкция
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Рабепразол-СЗ капс. кш/раств.
Рабепразол-СЗ капс. кш/раств., 10 мг, 28 шт.
У продавца: 
нет • На Маркете: 4.8
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    Цена 2 134 ₽ вместо 2 178
  • Кларитромицин таб. п/о плен., 250 мг, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1434054534_2/content/content/gallery":{"title":"Кларитромицин таб. п/о плен., 250 мг, 10 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id5591300220180474006.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id5591300220180474006.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id5591300220180474006.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id5591300220180474006.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id5591300220180474006.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id5591300220180474006.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5236045/img_id3373670622561367433.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5236045/img_id3373670622561367433.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5236045/img_id3373670622561367433.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5236045/img_id3373670622561367433.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5236045/img_id3373670622561367433.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5236045/img_id3373670622561367433.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCIbf56sFEPqFntgBGJaD2Acg99zBBw==","sign":"XZZhlT7410Q/F6hZ1rbnAdbMggMv5PYds1Oa6uNf3fI="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1434054534_2/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Кларитромицин таб. п/о плен., 250 мг, 10 шт.

    Цена 224 ₽
  • Бак-сет форте капс., 20 шт., 1 уп.
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    Бак-сет форте капс., 20 шт., 1 уп.

    Цена 870 ₽
  • Гепатрин капс., 120 шт.
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    Гепатрин капс., 120 шт.

    Цена 886 ₽ вместо 1 000
  • Жидкий пластырь Fixplast c пантенолом, 60 мл
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:963598113_5/content/content/gallery":{"title":"Жидкий пластырь Fixplast c пантенолом, 60 мл","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/12387925/2a0000018d4428f3eddc678971ad9112f525/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/12387925/2a0000018d4428f3eddc678971ad9112f525/120x160 120w, https://avatars.mds.yandex.net/get-mpic/12387925/2a0000018d4428f3eddc678971ad9112f525/180x240 180w, https://avatars.mds.yandex.net/get-mpic/12387925/2a0000018d4428f3eddc678971ad9112f525/240x320 240w, https://avatars.mds.yandex.net/get-mpic/12387925/2a0000018d4428f3eddc678971ad9112f525/300x400 300w, https://avatars.mds.yandex.net/get-mpic/12387925/2a0000018d4428f3eddc678971ad9112f525/600x800 600w","sizes":"(max-width: 1456px) 15vw, 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    Жидкий пластырь Fixplast c пантенолом, 60 мл

    Цена 355 ₽ вместо 399
  • Vitamin D3, 50000 МЕ, 50 мл, 50 шт.
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    Vitamin D3, 50000 МЕ, 50 мл, 50 шт.

    Цена 1 355 ₽ вместо 1 940
  • Тетрациклин таб. п/о плен., 100 мг, 20 шт.
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    Тетрациклин таб. п/о плен., 100 мг, 20 шт.

    Цена 138 ₽
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    Реклама
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  • Гастрарекс Нео капс., 30 шт., 1 уп.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1775167564_9/content/content/toggleWishlist":{"skuId":"101841746550","productId":1775167564,"offerId":"MhJb4u7-PZ2VJt6cGeKxhQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCMzQu84GEPb09rH7Ahj33NAHINrZwQc=","sign":"iXb8h5rHKUneXUonHnUU4QemaCgKQQnsNMU0+cAnl/s="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1775167564_9/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гастрарекс Нео капс., 30 шт., 1 уп.

    Цена 1 011 ₽ вместо 1 459
  • Амоксициллин Диспертаб таб., 125 мг, 20 шт.
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    Амоксициллин Диспертаб таб., 125 мг, 20 шт.

    Цена 214 ₽
  • Симетикон с фенхелем капс., 80 мг, 25 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400530495_11/content/content/gallery":{"title":"Симетикон с фенхелем капс., 80 мг, 25 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/8139064/img_id2705691524376382817.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/8139064/img_id2705691524376382817.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/8139064/img_id2705691524376382817.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/8139064/img_id2705691524376382817.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/8139064/img_id2705691524376382817.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/8139064/img_id2705691524376382817.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5314345/img_id3750522423575695352.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5314345/img_id3750522423575695352.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5314345/img_id3750522423575695352.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5314345/img_id3750522423575695352.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5314345/img_id3750522423575695352.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5314345/img_id3750522423575695352.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCL/M6ZsFEMbX+sv6AhjVu6EGINrZwQc=","sign":"68nmvDcgu8S1GothJ8uEj1230XcT6ZDh4Vm5qjJ+W0s="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400530495_11/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Симетикон с фенхелем капс., 80 мг, 25 шт.

    Цена 464 ₽ вместо 469
  • Овесол таб. п/о, 40 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:265146315_12/content/content/gallery":{"title":"Овесол таб. п/о, 40 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5236698/img_id1387505575400981091.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5236698/img_id1387505575400981091.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5236698/img_id1387505575400981091.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5236698/img_id1387505575400981091.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5236698/img_id1387505575400981091.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5236698/img_id1387505575400981091.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1521939/img_id3889216527551462908.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1521939/img_id3889216527551462908.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1521939/img_id3889216527551462908.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1521939/img_id3889216527551462908.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1521939/img_id3889216527551462908.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1521939/img_id3889216527551462908.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5235907/img_id4844923768706176602.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5235907/img_id4844923768706176602.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5235907/img_id4844923768706176602.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5235907/img_id4844923768706176602.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5235907/img_id4844923768706176602.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5235907/img_id4844923768706176602.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5242010/img_id2727451308730251725.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5242010/img_id2727451308730251725.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5242010/img_id2727451308730251725.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5242010/img_id2727451308730251725.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5242010/img_id2727451308730251725.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5242010/img_id2727451308730251725.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5255164/img_id706070053355706819.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5255164/img_id706070053355706819.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5255164/img_id706070053355706819.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5255164/img_id706070053355706819.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5255164/img_id706070053355706819.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5255164/img_id706070053355706819.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMuft34Q5ZKbufoCGNW7oQYg2tnBBw==","sign":"CF8FtyOy4JkH4jd/Ts/1AgqWWBjQAVk89Py3J/Hncg8="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:265146315_12/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Овесол таб. п/о, 40 шт.

    Цена 477 ₽ вместо 482
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:997279548_13/content/content/gallery":{"title":"БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCLyOxdsDEPTRh9H5Ahj03/kHINrZwQc=","sign":"K7lLMJ6dgx2kRJD8OG2dYqqnUOS2tyt61lIQpZbkCwk="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:997279548_13/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 1 752 ₽ вместо 3 500
  • Нимесил гран. д/приг. сусп. д/вн. приема пак., 100 мг, 2 г, 9 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:537870049_14/content/content/gallery":{"title":"Нимесил гран. д/приг. сусп. д/вн. приема пак., 100 мг, 2 г, 9 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4450422/img_id1999195994763970345.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4450422/img_id1999195994763970345.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4450422/img_id1999195994763970345.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4450422/img_id1999195994763970345.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4450422/img_id1999195994763970345.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4450422/img_id1999195994763970345.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4399094/img_id126938949737733374.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4399094/img_id126938949737733374.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4399094/img_id126938949737733374.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4399094/img_id126938949737733374.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4399094/img_id126938949737733374.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4399094/img_id126938949737733374.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4887676/img_id819731785687532554.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4887676/img_id819731785687532554.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4887676/img_id819731785687532554.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4887676/img_id819731785687532554.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4887676/img_id819731785687532554.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4887676/img_id819731785687532554.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCOH9vIACEMSHq8v5AhiOhIoRIOfcwQc=","sign":"tH2F9wAUVO91DJq5i95mLjKKUQcDuDc7uazULCHWSSo="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:537870049_14/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Нимесил гран. д/приг. сусп. д/вн. приема пак., 100 мг, 2 г, 9 шт.

    Цена 438 ₽
  • Бифидумбактерин-1000 таб., 30 шт., 1 уп.
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    Бифидумбактерин-1000 таб., 30 шт., 1 уп.

    Цена 188 ₽ вместо 224
  • Пепидол ПЭГ для взрослых р-р д/вн. приема, 5%, 250 мл, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799663_16/content/content/gallery":{"title":"Пепидол ПЭГ для взрослых р-р д/вн. приема, 5%, 250 мл, 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4591438/img_id2381043978361456350.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4591438/img_id2381043978361456350.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4591438/img_id2381043978361456350.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4591438/img_id2381043978361456350.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4591438/img_id2381043978361456350.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4591438/img_id2381043978361456350.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5232180/img_id3887185731663749476.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5232180/img_id3887185731663749476.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5232180/img_id3887185731663749476.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5232180/img_id3887185731663749476.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5232180/img_id3887185731663749476.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5232180/img_id3887185731663749476.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCK+D+psFEOOCyMkCGOKI3wYg2tnBBw==","sign":"FIxt9DQWAf0FKPYmrJGhgOyNJpG8NLUXF8+E03vR1OA="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799663_16/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Пепидол ПЭГ для взрослых р-р д/вн. приема, 5%, 250 мл, 1 уп.

    Цена 584 ₽ вместо 649
  • Синбиотик Мax капс., 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857432_17/content/content/gallery":{"title":"Синбиотик Мax капс., 10 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4355034/img_id2525393190476102753.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4355034/img_id2525393190476102753.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4355034/img_id2525393190476102753.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4355034/img_id2525393190476102753.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4355034/img_id2525393190476102753.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4355034/img_id2525393190476102753.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/7179065/img_id6156889551370604076.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/7179065/img_id6156889551370604076.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/7179065/img_id6156889551370604076.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/7179065/img_id6156889551370604076.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/7179065/img_id6156889551370604076.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/7179065/img_id6156889551370604076.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5277040/img_id6403689681369488285.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5277040/img_id6403689681369488285.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5277040/img_id6403689681369488285.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5277040/img_id6403689681369488285.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5277040/img_id6403689681369488285.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5277040/img_id6403689681369488285.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5315102/img_id4823766322253410072.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5315102/img_id4823766322253410072.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5315102/img_id4823766322253410072.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5315102/img_id4823766322253410072.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5315102/img_id4823766322253410072.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5315102/img_id4823766322253410072.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCNj0ltEGENa1i8ICGKC79gUg2tnBBw==","sign":"jKX9Ws1e0Am71yh3WejGz+6RFtj7LM6iPfiWwHwsolA="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857432_17/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857432_17/content/content/toggleWishlist":{"skuId":"675470038","productId":1780857432,"offerId":"HhjlsO5Bb8v_Tr-nUUwAdQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCNj0ltEGENa1i8ICGKC79gUg2tnBBw==","sign":"jKX9Ws1e0Am71yh3WejGz+6RFtj7LM6iPfiWwHwsolA="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857432_17/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Синбиотик Мax капс., 10 шт.

    Цена 242 ₽ вместо 246
  • Амоксициллин Экспресс таб. дисперг., 250 мг, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1434054586_18/content/content/toggleWishlist":{"skuId":"661793004","productId":1434054586,"offerId":"ij7eRVxe1Ji2L6S1RjM4xA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQhdiQ5+WL+LdaEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCLrf56sFEOzRyLsCGITU0Acg99zBBw==","sign":"OtrJOZgMnDERshPxBNe8XORNpK/leru/8i6wj/MgJbE="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1434054586_18/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Амоксициллин Экспресс таб. дисперг., 250 мг, 20 шт.

    Цена 276 ₽
  • Метронидазол таб., 250 мг, 20 шт.
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    Метронидазол таб., 250 мг, 20 шт.

    Цена 44 ₽
  • Флемоксин Солютаб.таб. дисперг., 125 мг, 20 шт.
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    Флемоксин Солютаб.таб. дисперг., 125 мг, 20 шт.

    Цена 233 ₽
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    Реклама
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  • Амоксициллин Сандоз таб. п/о плен., 1 г, 12 шт.
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    Амоксициллин Сандоз таб. п/о плен., 1 г, 12 шт.

    Цена 236 ₽
  • Макмирор таб. п/о, 200 мг, 20 шт.
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    Макмирор таб. п/о, 200 мг, 20 шт.

    Цена 1 495 ₽ вместо 1 689
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