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4.6
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Коротко о товаре

Артикул Маркета
4111758819
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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Оболочка: зеин 2,45 мг, триэтилцитрат 0,25 мг, Оболочка кишечнорастворимая: метакриловой кислоты и этилакрилата сополимер [1:1](метакриловой кислоты сополимер (тип С)) 12,05 мг, триэтилцитрат 1,20 мг, тальк 0,65 мг. Оболочка: Опадрай розовый О3В54475 2,70 мг (гипромеллоза 6сР 62,50%, титана диоксид (Е171) 28,70%, макрогол-400 6,25%, краситель железа оксид красный (Е172) 2,55%)."},{"name":"Действующее вещество","value":"Рабепразол","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28709641"]}}},{"name":"Способ применения и дозы","value":"Таблетки принимают внутрь целиком, не разжевывая и не измельчая. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола.\u003Cbr\u003E\nПри язвенной болезни желудка в стадии обострения и язве анастомоза рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Обычно излечение наступает после 6 недель терапии, однако в некоторых случаях длительность лечения может быть увеличена еще на 6 недель. \u003Cbr\u003E\nПри язвенной болезни двенадцатиперстной кишки в стадии обострения рекомендуется принимать внутрь по 20 мг один раз в день. В некоторых случаях лечебный эффект наступает при приеме 10 мг один раз в день. Длительность лечения составляет от 2 до 4 недель. В случае необходимости длительность лечения может быть увеличена еще на 4 недели. \u003Cbr\u003E\nПри лечении эрозивной гастроэзофагеальной рефлюксной болезни или рефлюкс-эзофагите рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения составляет от 4 до 8 недель. В случае необходимости длительность лечения может быть увеличена еще на 8 недель. \u003Cbr\u003E\nПри поддерживающей терапии гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения зависит от состояния пациента. \u003Cbr\u003E\nПри неэрозивной гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Если после четырех недель лечения симптомы не исчезают, следует провести дополнительное исследование пациента. После купирования симптомов для предупреждения их последующего возникновения следует принимать препарат внутрь в дозе 10 мг один раз в день. \u003Cbr\u003E\nДля лечения синдрома Золлингера-Эллисона и других состояний, характеризующихся патологической гиперсекрецией дозу подбирают индивидуально. Начальная доза - 60 мг в день, затем дозу повышают и назначают препарат в дозе до 100 мг в день при однократном приеме или по 60 мг два раза в день. Для некоторых пациентов дробное дозирование препарата является предпочтительным. Лечение должно продолжаться по мере клинической необходимости. У некоторых больных с синдромом Золлингера-Эллисона длительность лечения рабепразолом может составлять до одного года. \u003Cbr\u003E\nДля эрадикации Helicobacter pylori рекомендуется принимать внутрь по 20 мг два раза в день по определенной схеме с соответствующей комбинацией антибиотиков. Длительность лечения составляет 7 дней. \u003Cbr\u003E\nПациенты с почечной и печеночной недостаточностью. Коррекция дозы пациентам с почечной недостаточностью не требуется. У пациентов с легкой и умеренной степенью печеночной недостаточности концентрация рабепразола в крови обычно выше, чем у здоровых пациентов. При назначении препарата Разо пациентам с тяжелой степенью печеночной недостаточности следует соблюдать осторожность. \u003Cbr\u003E\nДети. Безопасность и эффективность применения рабепразола у детей в возрасте 12 лет и старше установлена для краткосрочного (до 8 недель) лечения ГЭРБ. Рекомендуемая доза для детей в возрасте 12 лет и старше составляет 20 мг 1 раз в день продолжительностью до 8 недель. Безопасность и эффективность рабепразола для применения по другим показаниям не установлена для пациентов детского возраста."},{"name":"Побочные действия","value":"Нарушения со стороны нервной системы: нечасто - головная боль, головокружение. \u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта: часто - запор, диарея, боль в животе, сухость слизистой оболочки полости рта, метеоризм; редко - гепатит, желтуха; у пациентов с циррозом печени - печеночная энцефалопатия. \u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей: редко - крапивница, буллезные высыпания, синдром Лайелла (токсический эпидермальный некролиз), синдром Стивенса-Джонсона (тяжелая многоформная эритема, характеризующаяся появлением пятен и пузырей на коже и слизистых оболочках на фоне высокой температуры и боли в суставах). \u003Cbr\u003E\nНарушения со стороны скелетно-мышечной и соединительной ткани: редко - миалгия, артралгия. \u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей: очень редко - интерстициальный нефрит. \u003Cbr\u003E\nЛабораторные и инструментальные данные: редко - тромбоцитопения, нейтропения, лейкопения, лейкоцитоз, повышение активности \"печеночных\" ферментов (трансаминаз), гипомагниемия. Возможно увеличение риска возникновения переломов костей"},{"name":"Фармакологическое действие","value":"Механизм действия. Рабепразол относится к классу антисекреторных соединений, которые в химическом отношении являются замещенными бензимидазолами. Препарат угнетает активность фермента H+/К+АТФ-азы (\"протонный насос\"), блокируя тем самым заключительную стадию синтеза соляной кислоты. Этот эффект носит дозозависимый характер и приводит к угнетению как базальной, так и стимулированной секреции соляной кислоты независимо от раздражителя. Как слабое основание рабепразол в любых дозах быстро абсорбируется и концентрируется в кислой среде париетальных клеток. Антисекреторная активность. После приема внутрь 20 мг рабепразола антисекреторный эффект возникает в течение одного часа. Угнетение базальной и стимулированной секреции соляной кислоты через 23 часа после приема первой дозы рабепразола натрия составляет 62 и 82%, соответственно, и продолжается до 48 часов. Такая продолжительность фармакокинетического действия намного превышает предсказуемое по периоду полувыведения (примерно на 1 час). Данный эффект может быть объяснен продолжительным связыванием лекарственного вещества с Н+/К+АТФ-азой париетальных клеток желудка. Величина ингибирующего действия рабепразола натрия на секрецию кислоты достигает плато после трех дней приема рабепразола натрия. При прекращении приема секреторная активность восстанавливается в течение 142 дней. Влияние на концентрацию гастрина в сыворотке. В начале терапии рабепразолом концентрация гастрина в сыворотке крови увеличивается, что является отражением ингибирующего влияния на секрецию соляной кислоты. Концентрация гастрина возвращается к исходному уровню обычно в течение 1~2 недель после прекращения лечения.\u003Cbr\u003E\nВлияние на энтерохромафинноподобные клетки. Изучение биоптатов дна и антрального отдела желудка более чем у 500 пациентов, получавших рабепразол натрия или препарат сравнения продолжительностью до 8 недель, не выявило изменений в морфологической структуре энтерохромафинноподобных (ЕСL) клеток, степени выраженности гастрита,частоте атрофического гастрита, кишечной метаплазии или распространенности инфекции Неlicоbactet pуlоri. В исследовании с участием более 400 пациентов, получавших рабепразол в дозе 10 мг/день или 20 мг/день, продолжительностью до 1 года, частота гиперплазии была низкой и сравнимой с таковой для пациентов, получавших омепразол в дозе 20 мг/день. Не был зарегистрирован ни один случай аденоматозных изменений или карциноидных опухолей, наблюдавшихся у крыс. \u003Cbr\u003E\nДругие эффекты.В настоящее время нет данных о том, что рабепразол вызывает системные эффекты со стороны центральной нервной системы (ЦНС), сердечно-сосудистой и дыхательной систем. При пероральном приеме в дозе 20 мг в течение 2 недель рабепразол не оказывал влияния на функцию щитовидной железы, метаболизм углеводов, а также на концентрации в крови паратиреоидного гормона, кортизола, эстрогенов, тестостерона, пролактина, секретина,глюкагона, фолликулостимулирующего гормона, лютеинизирующего гормона, ренина, альдостерона и соматотропного гормона."},{"name":"Фармакологическая группа","value":"ингибиторы протонного насоса"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы. Данные о намеренной или случайной передозировке минимальны. Сообщалось о приеме препарата в дозе 60 мг 2 раза в день или 160 мг однократно, при этом побочные эффекты были минимальны и обратимы и не требовали медицинского вмешательства. Лечение. Специфический антидот для препарата Разо неизвестен. Рабепразол хорошо связывается с белками плазмы, поэтому слабо выводится при диализе. При передозировке необходимо проводить симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Данных по безопасности применения рабепразола во время беременности нет. Исследования репродуктивности на крысах и кроликах не выявили признаков нарушения фертильности или дефектов развития плода, обусловленных рабепразолом; однако у крыс в небольших количествах препарат проникает через плацентарный барьер. Рабепразол не следует применять при беременности. Неизвестно, выделяется ли рабепразол с грудным молоком. Соответствующие исследования у кормящих женщин не проводились. Вместе с тем рабепразол обнаружен в молоке лактирующих крыс, поэтому препарат нельзя применять в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исходя из особенностей фармакодинамики рабепразола и его профиля нежелательных эффектов, маловероятно, что препарат Разо оказывает влияние на способность управлять транспортными средствами и выполнять другие виды деятельности, требующие концентрации внимания и быстроты психомоторных реакций. Однако в случае появления сонливости, головокружения следует избегать этих видов деятельности."},{"name":"Особые указания","value":"Ответ пациента на терапию рабепразолом натрия не исключает наличие злокачественных новообразований в желудке.\u003Cbr\u003E\nДо и после лечения обязателен эндоскопический контроль для исключения злокачественного новообразования, так как лечение может замаскировать симптоматику и отстрочить правильную диагностику. \u003Cbr\u003E\nРекомендуется соблюдать осторожность при первом назначении препарата Разо пациентам с тяжелыми нарушениями функции печени. \u003Cbr\u003E\nПациентам с нарушениями функции почек или печени корректировка дозы препарата Разо не требуется. AUC рабепразола натрия у пациентов с тяжелым нарушением функции печени примерно в два раза выше, чем у здоровых пациентов. \u003Cbr\u003E\nПрепарат не оказывает влияния на функцию щитовидной железы, метаболизм углеводов, на концентрацию в крови паратиреоидного гормона, кортизола, эстрогена, тестостерона, пролактина, холецистокинина, секретина, глюкагона, фолликулостимулирующего гормона, лютеинизирующего гормона, ренина, альдостерона и соматотропного гормона. \u003Cbr\u003E\nСогласно данным наблюдательных исследований терапия ингибиторами протонной помпы может привести к возрастанию риска связанных с остеопорозом переломов бедра, запястья, позвоночника. Риск переломов был увеличен у пациентов, получавших высокие дозы ингибиторов протонной помпы год и более."},{"name":"Взаимодействие","value":"В исследованиях in vitro на микросомах печени человека было показано, что рабепразолметаболизируется в печени изоферментами CYP2C19 и CYP3A4.\u003Cbr\u003E\nРабепразол не вступает в клинически значимые взаимодействия с амоксициллином и с другими лекарственными средствами, метаболизируемыми изоферментами системы цитохрома Р450 в печени: варфарином, фенитоином, теофиллином и диазепамом. \u003Cbr\u003E\nВ связи с тем, что рабепразол вызывает выраженное и длительное снижение выработки соляной кислоты, отмечалось взаимодействие при одновременном приеме с препаратами, абсорбция которых зависит от кислотности содержимого желудка. У здоровых добровольцев прием рабепразола вызывал снижение концентрации кетоконазола в плазме крови на 30% и повышение минимальной концентрации дигоксина на 22%. При одновременном приеме рабепразола с кетоконазолом или дигоксином необходимо корректировать их дозы. \u003Cbr\u003E\nПри одновременном приеме атазанавира 300 мг / ритонавира 100 мг с омепразолом (40 мг 1 раз в день) или с атазанавира 400 мг с лансопразолом (60 мг 1 раз в день) здоровыми добровольцами наблюдалось существенное снижение воздействия атазанавира. Абсорбция атазанавира зависит от pH. Таким образом, не рекомендуется одновременный прием атазанавира с ингибиторами протонного насоса, включая рабепразол. \u003Cbr\u003E\nКонцентрации рабепразола и активного метаболита кларитромицина в плазме крови при одновременном приеме увеличиваются на 24% и 50%, соответственно. Данный эффект используется при проведении эрадикации Helicobacter pylori. \u003Cbr\u003E\nОдновременный прием рабепразола и метотрексата может привести к повышению концентрации метотрексата и его метаболита гидроксиметотрексата и увеличить время их выведения. \u003Cbr\u003E\nНе обнаружено взаимодействия рабепразола с жидкими антацидными препаратами. \u003Cbr\u003E\nНе выявлено клинически значимого взаимодействия рабепразола с пищей."},{"name":"Регистрационный номер","value":"ЛП-002666"},{"name":"Дата государственной регистрации","value":"30.05.2018"},{"name":"Владелец регистрационного удостоверения","value":"Dr. Reddy's Laboratories","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:16077120"]}}},{"name":"Изготовитель","value":"Dr. Reddy's"},{"name":"Фасовщик","value":"Dr. Reddy's"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Разо","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18008653"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"7169844028213231039":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"желудок, пищеварительная система"},{"name":"Назначение","value":"гастроэзофагиальный рефлюкс, язвенная болезнь желудка и двенадцатиперстной кишки"},{"name":"Показания к применению","value":"- язвенная болезнь желудка в стадии обострения и язва анастомоза;\u003Cbr\u003E\n- язвенная болезнь двенадцатиперстной кишки в стадии обострения;\u003Cbr\u003E\n- эрозивная и язвенная гастроэзофагеальная рефлтоксная болезнь или рефлюкс-эзофагит;\u003Cbr\u003E\n- поддерживающая терапия гастроэзофагеальной рефлюксной болезни;\u003Cbr\u003E\n- неэрозивная гастроэзофагеальная рефлюксная болезнь;\u003Cbr\u003E\n- синдром Золлингера-Эллисона и другие состояния, характеризующиеся патологической гиперсекрецией.\u003Cbr\u003E\nВ составе комбинированной терапии:\u003Cbr\u003E\n- эрадикация Helicobacter pylori у пациентов с язвенной болезнью желудка и двенадцатиперстной кишки или хроническим гастритом."},{"name":"Противопоказания","value":"Повышенная чувствительность к рабепразолу, замещенным бензимидазолам или к вспомогательным компонентам препарата; беременность; период грудного вскармливания (лактации); детский возраст до 12 лет."},{"name":"Состав","value":"Каждая таблетка, покрытая кишечнорастворимой оболочкой, 10 мг содержит: действующее вещество: рабепразол натрия 10 мг; вспомогательные вещества: маннитол 48,505 мг, гипролоза низкозамещенная 7,20 мг,магния оксид тяжелый 20,00 мг, гипромеллоза (5срs) 1,50 мг, натрия лаурилсульфат 0,90мг,тальк 0,77 мг, магния стеарат 1,125 мг. Оболочка: зеин 2,45 мг, триэтилцитрат 0,25 мг, Оболочка кишечнорастворимая: метакриловой кислоты и этилакрилата сополимер [1:1](метакриловой кислоты сополимер (тип С)) 12,05 мг, триэтилцитрат 1,20 мг, тальк 0,65 мг. Оболочка: Опадрай розовый О3В54475 2,70 мг (гипромеллоза 6сР 62,50%, титана диоксид (Е171) 28,70%, макрогол-400 6,25%, краситель железа оксид красный (Е172) 2,55%)."},{"name":"Действующее вещество","value":"Рабепразол"},{"name":"Способ применения и дозы","value":"Таблетки принимают внутрь целиком, не разжевывая и не измельчая. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола.\u003Cbr\u003E\nПри язвенной болезни желудка в стадии обострения и язве анастомоза рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Обычно излечение наступает после 6 недель терапии, однако в некоторых случаях длительность лечения может быть увеличена еще на 6 недель. \u003Cbr\u003E\nПри язвенной болезни двенадцатиперстной кишки в стадии обострения рекомендуется принимать внутрь по 20 мг один раз в день. В некоторых случаях лечебный эффект наступает при приеме 10 мг один раз в день. Длительность лечения составляет от 2 до 4 недель. В случае необходимости длительность лечения может быть увеличена еще на 4 недели. \u003Cbr\u003E\nПри лечении эрозивной гастроэзофагеальной рефлюксной болезни или рефлюкс-эзофагите рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения составляет от 4 до 8 недель. В случае необходимости длительность лечения может быть увеличена еще на 8 недель. \u003Cbr\u003E\nПри поддерживающей терапии гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения зависит от состояния пациента. \u003Cbr\u003E\nПри неэрозивной гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Если после четырех недель лечения симптомы не исчезают, следует провести дополнительное исследование пациента. После купирования симптомов для предупреждения их последующего возникновения следует принимать препарат внутрь в дозе 10 мг один раз в день. \u003Cbr\u003E\nДля лечения синдрома Золлингера-Эллисона и других состояний, характеризующихся патологической гиперсекрецией дозу подбирают индивидуально. Начальная доза - 60 мг в день, затем дозу повышают и назначают препарат в дозе до 100 мг в день при однократном приеме или по 60 мг два раза в день. Для некоторых пациентов дробное дозирование препарата является предпочтительным. Лечение должно продолжаться по мере клинической необходимости. У некоторых больных с синдромом Золлингера-Эллисона длительность лечения рабепразолом может составлять до одного года. \u003Cbr\u003E\nДля эрадикации Helicobacter pylori рекомендуется принимать внутрь по 20 мг два раза в день по определенной схеме с соответствующей комбинацией антибиотиков. Длительность лечения составляет 7 дней. \u003Cbr\u003E\nПациенты с почечной и печеночной недостаточностью. Коррекция дозы пациентам с почечной недостаточностью не требуется. У пациентов с легкой и умеренной степенью печеночной недостаточности концентрация рабепразола в крови обычно выше, чем у здоровых пациентов. При назначении препарата Разо пациентам с тяжелой степенью печеночной недостаточности следует соблюдать осторожность. \u003Cbr\u003E\nДети. Безопасность и эффективность применения рабепразола у детей в возрасте 12 лет и старше установлена для краткосрочного (до 8 недель) лечения ГЭРБ. Рекомендуемая доза для детей в возрасте 12 лет и старше составляет 20 мг 1 раз в день продолжительностью до 8 недель. Безопасность и эффективность рабепразола для применения по другим показаниям не установлена для пациентов детского возраста."},{"name":"Побочные действия","value":"Нарушения со стороны нервной системы: нечасто - головная боль, головокружение. \u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта: часто - запор, диарея, боль в животе, сухость слизистой оболочки полости рта, метеоризм; редко - гепатит, желтуха; у пациентов с циррозом печени - печеночная энцефалопатия. \u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей: редко - крапивница, буллезные высыпания, синдром Лайелла (токсический эпидермальный некролиз), синдром Стивенса-Джонсона (тяжелая многоформная эритема, характеризующаяся появлением пятен и пузырей на коже и слизистых оболочках на фоне высокой температуры и боли в суставах). \u003Cbr\u003E\nНарушения со стороны скелетно-мышечной и соединительной ткани: редко - миалгия, артралгия. \u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей: очень редко - интерстициальный нефрит. \u003Cbr\u003E\nЛабораторные и инструментальные данные: редко - тромбоцитопения, нейтропения, лейкопения, лейкоцитоз, повышение активности \"печеночных\" ферментов (трансаминаз), гипомагниемия. Возможно увеличение риска возникновения переломов костей"},{"name":"Фармакологическое действие","value":"Механизм действия. Рабепразол относится к классу антисекреторных соединений, которые в химическом отношении являются замещенными бензимидазолами. Препарат угнетает активность фермента H+/К+АТФ-азы (\"протонный насос\"), блокируя тем самым заключительную стадию синтеза соляной кислоты. Этот эффект носит дозозависимый характер и приводит к угнетению как базальной, так и стимулированной секреции соляной кислоты независимо от раздражителя. Как слабое основание рабепразол в любых дозах быстро абсорбируется и концентрируется в кислой среде париетальных клеток. Антисекреторная активность. После приема внутрь 20 мг рабепразола антисекреторный эффект возникает в течение одного часа. Угнетение базальной и стимулированной секреции соляной кислоты через 23 часа после приема первой дозы рабепразола натрия составляет 62 и 82%, соответственно, и продолжается до 48 часов. Такая продолжительность фармакокинетического действия намного превышает предсказуемое по периоду полувыведения (примерно на 1 час). Данный эффект может быть объяснен продолжительным связыванием лекарственного вещества с Н+/К+АТФ-азой париетальных клеток желудка. Величина ингибирующего действия рабепразола натрия на секрецию кислоты достигает плато после трех дней приема рабепразола натрия. При прекращении приема секреторная активность восстанавливается в течение 142 дней. Влияние на концентрацию гастрина в сыворотке. В начале терапии рабепразолом концентрация гастрина в сыворотке крови увеличивается, что является отражением ингибирующего влияния на секрецию соляной кислоты. Концентрация гастрина возвращается к исходному уровню обычно в течение 1~2 недель после прекращения лечения.\u003Cbr\u003E\nВлияние на энтерохромафинноподобные клетки. Изучение биоптатов дна и антрального отдела желудка более чем у 500 пациентов, получавших рабепразол натрия или препарат сравнения продолжительностью до 8 недель, не выявило изменений в морфологической структуре энтерохромафинноподобных (ЕСL) клеток, степени выраженности гастрита,частоте атрофического гастрита, кишечной метаплазии или распространенности инфекции Неlicоbactet pуlоri. В исследовании с участием более 400 пациентов, получавших рабепразол в дозе 10 мг/день или 20 мг/день, продолжительностью до 1 года, частота гиперплазии была низкой и сравнимой с таковой для пациентов, получавших омепразол в дозе 20 мг/день. Не был зарегистрирован ни один случай аденоматозных изменений или карциноидных опухолей, наблюдавшихся у крыс. \u003Cbr\u003E\nДругие эффекты.В настоящее время нет данных о том, что рабепразол вызывает системные эффекты со стороны центральной нервной системы (ЦНС), сердечно-сосудистой и дыхательной систем. При пероральном приеме в дозе 20 мг в течение 2 недель рабепразол не оказывал влияния на функцию щитовидной железы, метаболизм углеводов, а также на концентрации в крови паратиреоидного гормона, кортизола, эстрогенов, тестостерона, пролактина, секретина,глюкагона, фолликулостимулирующего гормона, лютеинизирующего гормона, ренина, альдостерона и соматотропного гормона."},{"name":"Фармакологическая группа","value":"ингибиторы протонного насоса"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы. Данные о намеренной или случайной передозировке минимальны. Сообщалось о приеме препарата в дозе 60 мг 2 раза в день или 160 мг однократно, при этом побочные эффекты были минимальны и обратимы и не требовали медицинского вмешательства. Лечение. Специфический антидот для препарата Разо неизвестен. Рабепразол хорошо связывается с белками плазмы, поэтому слабо выводится при диализе. При передозировке необходимо проводить симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Данных по безопасности применения рабепразола во время беременности нет. Исследования репродуктивности на крысах и кроликах не выявили признаков нарушения фертильности или дефектов развития плода, обусловленных рабепразолом; однако у крыс в небольших количествах препарат проникает через плацентарный барьер. Рабепразол не следует применять при беременности. Неизвестно, выделяется ли рабепразол с грудным молоком. Соответствующие исследования у кормящих женщин не проводились. Вместе с тем рабепразол обнаружен в молоке лактирующих крыс, поэтому препарат нельзя применять в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исходя из особенностей фармакодинамики рабепразола и его профиля нежелательных эффектов, маловероятно, что препарат Разо оказывает влияние на способность управлять транспортными средствами и выполнять другие виды деятельности, требующие концентрации внимания и быстроты психомоторных реакций. Однако в случае появления сонливости, головокружения следует избегать этих видов деятельности."},{"name":"Особые указания","value":"Ответ пациента на терапию рабепразолом натрия не исключает наличие злокачественных новообразований в желудке.\u003Cbr\u003E\nДо и после лечения обязателен эндоскопический контроль для исключения злокачественного новообразования, так как лечение может замаскировать симптоматику и отстрочить правильную диагностику. \u003Cbr\u003E\nРекомендуется соблюдать осторожность при первом назначении препарата Разо пациентам с тяжелыми нарушениями функции печени. \u003Cbr\u003E\nПациентам с нарушениями функции почек или печени корректировка дозы препарата Разо не требуется. AUC рабепразола натрия у пациентов с тяжелым нарушением функции печени примерно в два раза выше, чем у здоровых пациентов. \u003Cbr\u003E\nПрепарат не оказывает влияния на функцию щитовидной железы, метаболизм углеводов, на концентрацию в крови паратиреоидного гормона, кортизола, эстрогена, тестостерона, пролактина, холецистокинина, секретина, глюкагона, фолликулостимулирующего гормона, лютеинизирующего гормона, ренина, альдостерона и соматотропного гормона. \u003Cbr\u003E\nСогласно данным наблюдательных исследований терапия ингибиторами протонной помпы может привести к возрастанию риска связанных с остеопорозом переломов бедра, запястья, позвоночника. Риск переломов был увеличен у пациентов, получавших высокие дозы ингибиторов протонной помпы год и более."},{"name":"Взаимодействие","value":"В исследованиях in vitro на микросомах печени человека было показано, что рабепразолметаболизируется в печени изоферментами CYP2C19 и CYP3A4.\u003Cbr\u003E\nРабепразол не вступает в клинически значимые взаимодействия с амоксициллином и с другими лекарственными средствами, метаболизируемыми изоферментами системы цитохрома Р450 в печени: варфарином, фенитоином, теофиллином и диазепамом. \u003Cbr\u003E\nВ связи с тем, что рабепразол вызывает выраженное и длительное снижение выработки соляной кислоты, отмечалось взаимодействие при одновременном приеме с препаратами, абсорбция которых зависит от кислотности содержимого желудка. У здоровых добровольцев прием рабепразола вызывал снижение концентрации кетоконазола в плазме крови на 30% и повышение минимальной концентрации дигоксина на 22%. При одновременном приеме рабепразола с кетоконазолом или дигоксином необходимо корректировать их дозы. \u003Cbr\u003E\nПри одновременном приеме атазанавира 300 мг / ритонавира 100 мг с омепразолом (40 мг 1 раз в день) или с атазанавира 400 мг с лансопразолом (60 мг 1 раз в день) здоровыми добровольцами наблюдалось существенное снижение воздействия атазанавира. Абсорбция атазанавира зависит от pH. Таким образом, не рекомендуется одновременный прием атазанавира с ингибиторами протонного насоса, включая рабепразол. \u003Cbr\u003E\nКонцентрации рабепразола и активного метаболита кларитромицина в плазме крови при одновременном приеме увеличиваются на 24% и 50%, соответственно. Данный эффект используется при проведении эрадикации Helicobacter pylori. \u003Cbr\u003E\nОдновременный прием рабепразола и метотрексата может привести к повышению концентрации метотрексата и его метаболита гидроксиметотрексата и увеличить время их выведения. \u003Cbr\u003E\nНе обнаружено взаимодействия рабепразола с жидкими антацидными препаратами. \u003Cbr\u003E\nНе выявлено клинически значимого взаимодействия рабепразола с пищей."},{"name":"Регистрационный номер","value":"ЛП-002666"},{"name":"Дата государственной регистрации","value":"30.05.2018"},{"name":"Владелец регистрационного удостоверения","value":"Dr. Reddy's Laboratories"},{"name":"Изготовитель","value":"Dr. Reddy's"},{"name":"Фасовщик","value":"Dr. Reddy's"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Разо"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_12364481733647844529"}}}}
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  • Гепатрин капс., 120 шт.
    –11 %
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    Гепатрин капс., 120 шт.

    Рейтинг товара: 4.8 из 5
    на основе 885 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 886 ₽ вместо 895
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  • Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.
    –8 %
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    Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 765 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 569 ₽ вместо 575
    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  • Геварус Про Гастро капс., 102 мл, 20 г, 10 шт., нейтральный, 1 уп.
    –41 %
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    Геварус Про Гастро капс., 102 мл, 20 г, 10 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 17 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 415 ₽ вместо 423
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Про Гастро капс., 102 мл, 20 г, 10 шт., нейтральный, 1 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  • California Gold Nutrition LactoBif капс., 5 млрд КОЕ, 30 г, 10 шт., нейтральный, 1 уп.
    –34 %
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    California Gold Nutrition LactoBif капс., 5 млрд КОЕ, 30 г, 10 шт., нейтральный, 1 уп.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 456 ₽ вместо 1 486
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  • Альфазокс р-р д/вн прим. саше, 10 мл, 20 шт., 1 уп.
    –1 %
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    Альфазокс р-р д/вн прим. саше, 10 мл, 20 шт., 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 155 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 153 ₽ вместо 1 165
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  • Фитолакс таб. жев., 20 шт., абрикос, 1 уп.
    –2 %
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    Фитолакс таб. жев., 20 шт., абрикос, 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 35 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 350 ₽ вместо 358
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  • California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.
    –30 %
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    California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.8 из 5
    на основе 727 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 103 ₽ вместо 1 114
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  • Хелинорм капс., 28 шт., 1 уп.
    –2 %
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    Хелинорм капс., 28 шт., 1 уп.

    Рейтинг товара: 5 из 5
    на основе 8 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 134 ₽ вместо 2 178
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  • Бак-сет форте капс., 210 г, 20 шт., 1 уп.
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    Бак-сет форте капс., 210 г, 20 шт., 1 уп.

    Цена 870 ₽
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  • Бифидумбактерин-1000 таб., 30 шт., 1 уп.
    –16 %
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    Бифидумбактерин-1000 таб., 30 шт., 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 50 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 188 ₽ вместо 190
    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таб., 30 шт., 1 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  • California Gold Nutrition LactoBif капс., 30 млрд КОЕ, 130 г, 60 шт., нейтральный, 1 уп.
    –38 %
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    California Gold Nutrition LactoBif капс., 30 млрд КОЕ, 130 г, 60 шт., нейтральный, 1 уп.

    Рейтинг товара: 4.9 из 5
    на основе 1000 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 3 714 ₽ вместо 3 790
    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Gold Nutrition LactoBif капс., 30 млрд КОЕ, 130 г, 60 шт., нейтральный, 1 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Инструкция

Показания к применению

- язвенная болезнь желудка в стадии обострения и язва анастомоза;
- язвенная болезнь двенадцатиперстной кишки в стадии обострения;
- эрозивная и язвенная гастроэзофагеальная рефлтоксная болезнь или рефлюкс-эзофагит;
- поддерживающая терапия гастроэзофагеальной рефлюксной болезни;
- неэрозивная гастроэзофагеальная рефлюксная болезнь;
- синдром Золлингера-Эллисона и другие состояния, характеризующиеся патологической гиперсекрецией.
В составе комбинированной терапии:
- эрадикация Helicobacter pylori у пациентов с язвенной болезнью желудка и двенадцатиперстной кишки или хроническим гастритом.

Противопоказания

Повышенная чувствительность к рабепразолу, замещенным бензимидазолам или к вспомогательным компонентам препарата; беременность; период грудного вскармливания (лактации); детский возраст до 12 лет.

Способ применения и дозы

Таблетки принимают внутрь целиком, не разжевывая и не измельчая. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола.
При язвенной болезни желудка в стадии обострения и язве анастомоза рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Обычно излечение наступает после 6 недель терапии, однако в некоторых случаях длительность лечения может быть увеличена еще на 6 недель.
При язвенной болезни двенадцатиперстной кишки в стадии обострения рекомендуется принимать внутрь по 20 мг один раз в день. В некоторых случаях лечебный эффект наступает при приеме 10 мг один раз в день. Длительность лечения составляет от 2 до 4 недель. В случае необходимости длительность лечения может быть увеличена еще на 4 недели.
При лечении эрозивной гастроэзофагеальной рефлюксной болезни или рефлюкс-эзофагите рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения составляет от 4 до 8 недель. В случае необходимости длительность лечения может быть увеличена еще на 8 недель.
При поддерживающей терапии гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения зависит от состояния пациента.
При неэрозивной гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Если после четырех недель лечения симптомы не исчезают, следует провести дополнительное исследование пациента. После купирования симптомов для предупреждения их последующего возникновения следует принимать препарат внутрь в дозе 10 мг один раз в день.
Для лечения синдрома Золлингера-Эллисона и других состояний, характеризующихся патологической гиперсекрецией дозу подбирают индивидуально. Начальная доза - 60 мг в день, затем дозу повышают и назначают препарат в дозе до 100 мг в день при однократном приеме или по 60 мг два раза в день. Для некоторых пациентов дробное дозирование препарата является предпочтительным. Лечение должно продолжаться по мере клинической необходимости. У некоторых больных с синдромом Золлингера-Эллисона длительность лечения рабепразолом может составлять до одного года.
Для эрадикации Helicobacter pylori рекомендуется принимать внутрь по 20 мг два раза в день по определенной схеме с соответствующей комбинацией антибиотиков. Длительность лечения составляет 7 дней.
Пациенты с почечной и печеночной недостаточностью. Коррекция дозы пациентам с почечной недостаточностью не требуется. У пациентов с легкой и умеренной степенью печеночной недостаточности концентрация рабепразола в крови обычно выше, чем у здоровых пациентов. При назначении препарата Разо пациентам с тяжелой степенью печеночной недостаточности следует соблюдать осторожность.
Дети. Безопасность и эффективность применения рабепразола у детей в возрасте 12 лет и старше установлена для краткосрочного (до 8 недель) лечения ГЭРБ. Рекомендуемая доза для детей в возрасте 12 лет и старше составляет 20 мг 1 раз в день продолжительностью до 8 недель. Безопасность и эффективность рабепразола для применения по другим показаниям не установлена для пациентов детского возраста.
Полная инструкция
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Разо таб. п/о кш/раств.
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4.6
(20)
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Инструкция

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4.6
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У продавца:20 оценок·8 отзывов
У всех продавцов:81 оценка·37 отзывов
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user avatar
9 месяцев назад • Ирина Николаева • Куплен на Маркете
Достоинства: Помогают, небольшие (легко запиваются), нет аллергической реакции.
Недостатки: Не обнаружены.
Комментарий: Отличные таблетки, помогают при заболеваниях ЖКТ. Гастроэнтеролог прописал годовой курс с перерывом в 2-3 месяца, и данные таблетки входят в каждый курс и всегда помогают, аллергической реакции не выявлено.
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2 месяца назад • Наталья Черепанова • Куплен на Маркете
Достоинства: Срок годности хороший, упаковка целая
Недостатки: нет
Комментарий: Был назначен как поддерживающая терапия гастроэзофагеальной рефлюксной болезни, со своей задачей справился
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6 месяцев назад • Сергей С. • Куплен на Маркете
Достоинства: Хороший препарат при ГЭРБ. Но использовать надо с умом и по назначению врача.
Недостатки: По хорошему надо пить за 10 минут до еды. Если изжога уже случилась, то эффективность ниже, чем выпив таблетку заранее.
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Рекомендуем

  • Тербинафин крем, 1%, 15 г, 1 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172509_0/content/content/toggleWishlist":{"skuId":"186426317","productId":1778172509,"offerId":"mrIf_QBYVgDHPb47RI8xeg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCN2E888GEM3H8lgY4tzQByDh2cEH","sign":"rIbHzhCBgPNzXi169NEQLKi5xJ8mR08XBsTTqBI1dXU="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778172509_0/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Тербинафин крем, 1%, 15 г, 1 шт.

    Цена 79 ₽ вместо 80
  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_1/content/content/gallery":{"title":"Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCJ358s8GEP7T0WwY1buhBiDa2cEH","sign":"gceEjpFsGJFr8ZMK7jpfBwpCF5NxZXznVotPX6ADATs="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_1/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_1/content/content/toggleWishlist":{"skuId":"227830270","productId":1778171037,"offerId":"pQcXMJSrQ6Doa9yziMm5Vg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCJ358s8GEP7T0WwY1buhBiDa2cEH","sign":"gceEjpFsGJFr8ZMK7jpfBwpCF5NxZXznVotPX6ADATs="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_1/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Цена 812 ₽ вместо 1 039
  • Фенибут таб., 250 мг, 10 шт.
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    Фенибут таб., 250 мг, 10 шт.

    Цена 92 ₽
  • California Gold Nutrition LactoBif капс., 5 млрд КОЕ, 30 г, 10 шт., нейтральный, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1409950470_3/content/content/gallery":{"title":"California Gold Nutrition LactoBif капс., 5 млрд КОЕ, 30 г, 10 шт., нейтральный, 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5268639/img_id5066936962070598270.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5268639/img_id5066936962070598270.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5268639/img_id5066936962070598270.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5268639/img_id5066936962070598270.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5268639/img_id5066936962070598270.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5268639/img_id5066936962070598270.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5233785/img_id4129762596357765591.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5233785/img_id4129762596357765591.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5233785/img_id4129762596357765591.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5233785/img_id4129762596357765591.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5233785/img_id4129762596357765591.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5233785/img_id4129762596357765591.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCIbGqKAFEIqE6ob6AhiSl4AOINrZwQc=","sign":"3cF5H8rgS+a9fBhnkQ5O4WjijqQzPyHD93PQpeEKRS4="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1409950470_3/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1409950470_3/content/content/toggleWishlist":{"skuId":"101482922506","productId":1409950470,"offerId":"AI75dBVhDAiVhhfyKFzJ4w","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCIbGqKAFEIqE6ob6AhiSl4AOINrZwQc=","sign":"3cF5H8rgS+a9fBhnkQ5O4WjijqQzPyHD93PQpeEKRS4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1409950470_3/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    California Gold Nutrition LactoBif капс., 5 млрд КОЕ, 30 г, 10 шт., нейтральный, 1 уп.

    Цена 1 456 ₽ вместо 2 200
  • Альфазокс р-р д/вн прим. саше, 10 мл, 20 шт., 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:649931041_4/content/content/gallery":{"title":"Альфазокс р-р д/вн прим. саше, 10 мл, 20 шт., 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5363625/img_id7212356403706494930.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5363625/img_id7212356403706494930.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5363625/img_id7212356403706494930.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5363625/img_id7212356403706494930.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5363625/img_id7212356403706494930.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5363625/img_id7212356403706494930.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/11404302/img_id3888527542129616675.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/11404302/img_id3888527542129616675.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/11404302/img_id3888527542129616675.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/11404302/img_id3888527542129616675.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/11404302/img_id3888527542129616675.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/11404302/img_id3888527542129616675.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCKHS9LUCEPqE++n5Ahjp9PYHINrZwQc=","sign":"X6nhnvTfqNlH4QflRfJmSS7rqwU827e7CUhWGmE/x6I="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:649931041_4/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:649931041_4/content/content/toggleWishlist":{"skuId":"101422383738","productId":649931041,"offerId":"kUhs-GtA30OSl8gr3iJvNQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCKHS9LUCEPqE++n5Ahjp9PYHINrZwQc=","sign":"X6nhnvTfqNlH4QflRfJmSS7rqwU827e7CUhWGmE/x6I="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:649931041_4/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Альфазокс р-р д/вн прим. саше, 10 мл, 20 шт., 1 уп.

    Цена 1 153 ₽ вместо 1 165
  • Фитолакс таб. жев., 20 шт., абрикос, 1 уп.
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    Фитолакс таб. жев., 20 шт., абрикос, 1 уп.

    Цена 350 ₽ вместо 358
  • Лимфомиозот капли д/вн. приема, 30 мл
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    Лимфомиозот капли д/вн. приема, 30 мл

    Цена 910 ₽ вместо 1 081
  • California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.
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    California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.

    Цена 1 103 ₽ вместо 1 581
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    Реклама
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  • Марля медицинская повышенной плотности, отрез 3 метра
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    Марля медицинская повышенной плотности, отрез 3 метра

    Цена 157 ₽ вместо 199
  • Хелинорм капс., 28 шт., 1 уп.
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    Хелинорм капс., 28 шт., 1 уп.

    Цена 2 134 ₽ вместо 2 178
  • Гепатрин капс., 120 шт.
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    Гепатрин капс., 120 шт.

    Цена 886 ₽ вместо 1 000
  • Бак-сет форте капс., 210 г, 20 шт., 1 уп.
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    Бак-сет форте капс., 210 г, 20 шт., 1 уп.

    Цена 870 ₽
  • Силденафил-СЗ таб. п/о плен., 100 мг, 10 шт.
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    Силденафил-СЗ таб. п/о плен., 100 мг, 10 шт.

    Цена 314 ₽
  • Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов
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    Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов

    Цена 194 ₽ вместо 224
  • Бифидумбактерин-1000 таб., 30 шт., 1 уп.
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    Бифидумбактерин-1000 таб., 30 шт., 1 уп.

    Цена 188 ₽ вместо 224
  • California Gold Nutrition LactoBif капс., 30 млрд КОЕ, 130 г, 60 шт., нейтральный, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1398090366_16/content/content/gallery":{"title":"California Gold Nutrition LactoBif капс., 30 млрд КОЕ, 130 г, 60 шт., нейтральный, 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5235182/img_id4495031649943492108.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5235182/img_id4495031649943492108.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5235182/img_id4495031649943492108.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5235182/img_id4495031649943492108.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5235182/img_id4495031649943492108.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5235182/img_id4495031649943492108.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5312584/img_id5448387915762100663.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5312584/img_id5448387915762100663.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5312584/img_id5448387915762100663.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5312584/img_id5448387915762100663.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5312584/img_id5448387915762100663.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5312584/img_id5448387915762100663.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCP7U1JoFELC3vMT6AhiSl4AOINrZwQc=","sign":"STG7dEnEEr/gVdnMJhRgo4nDQDmGdUg9DBbAA1JuzXo="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1398090366_16/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    California Gold Nutrition LactoBif капс., 30 млрд КОЕ, 130 г, 60 шт., нейтральный, 1 уп.

    Цена 3 714 ₽ вместо 6 000
  • Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1465757417_17/content/content/gallery":{"title":"Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5323357/img_id1050711991017123368.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5323357/img_id1050711991017123368.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5323357/img_id1050711991017123368.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5323357/img_id1050711991017123368.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5323357/img_id1050711991017123368.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5323357/img_id1050711991017123368.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5213758/img_id7364880641001109389.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5213758/img_id7364880641001109389.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5213758/img_id7364880641001109389.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5213758/img_id7364880641001109389.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5213758/img_id7364880641001109389.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5213758/img_id7364880641001109389.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5234463/img_id8161358201927858249.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5234463/img_id8161358201927858249.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5234463/img_id8161358201927858249.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5234463/img_id8161358201927858249.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5234463/img_id8161358201927858249.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5234463/img_id8161358201927858249.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4429951/img_id4975230452539849615.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4429951/img_id4975230452539849615.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4429951/img_id4975230452539849615.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4429951/img_id4975230452539849615.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4429951/img_id4975230452539849615.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4429951/img_id4975230452539849615.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5235448/img_id7764124425624270441.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5235448/img_id7764124425624270441.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5235448/img_id7764124425624270441.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5235448/img_id7764124425624270441.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5235448/img_id7764124425624270441.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5235448/img_id7764124425624270441.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5235101/img_id6707772831601574391.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5235101/img_id6707772831601574391.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5235101/img_id6707772831601574391.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5235101/img_id6707772831601574391.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5235101/img_id6707772831601574391.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5235101/img_id6707772831601574391.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCOnd9roFEOXA84b6AhjVu6EGINrZwQc=","sign":"0lctZQ9amwFHVTOhxx2AzKEIBv/Nrw8W0Qs3dVbFA8o="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1465757417_17/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Фитолакс ягоды мармеладные (на основе сенны) пастилки жев., 4 г, 30 шт., клубника, 1 уп.

    Цена 569 ₽ вместо 616
  • Геварус Про Гастро капс., 102 мл, 20 г, 10 шт., нейтральный, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1942447640_18/content/content/toggleWishlist":{"skuId":"102441219730","productId":1942447640,"offerId":"8xyC-8BlMJVQzHjFkfkAnA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCJjMnZ4HEJLt48/9AhjcpYURINrZwQc=","sign":"A9JpAuAIrxhHXXj78QaFj9xSrtC8ZVwBDVw0ZXrZNew="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1942447640_18/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Геварус Про Гастро капс., 102 мл, 20 г, 10 шт., нейтральный, 1 уп.

    Цена 415 ₽ вместо 699
  • Гилан ультра комфорт увлажн. гл. р-р, 0.3%, 0.4 мл, 50 г, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1417729433_19/content/content/gallery":{"title":"Гилан ультра комфорт увлажн. гл. р-р, 0.3%, 0.4 мл, 50 г, 10 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCJmrg6QFEKucmNsBGIfe0Acg3NzBBw==","sign":"O6GMcYyCxjWGrrcMNvJOUGu3Po/H9EuxuWeb/8m5uM8="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1417729433_19/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Гилан ультра комфорт увлажн. гл. р-р, 0.3%, 0.4 мл, 50 г, 10 шт.

    Цена 288 ₽ вместо 331
  • Нафтизин капли наз. фл.-кап., 0.1%, 10 мл
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:227814328_20/content/content/gallery":{"title":"Нафтизин капли наз. фл.-кап., 0.1%, 10 мл","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5236584/img_id7142322021083763096.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5236584/img_id7142322021083763096.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5236584/img_id7142322021083763096.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5236584/img_id7142322021083763096.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5236584/img_id7142322021083763096.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5236584/img_id7142322021083763096.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1603927/img_id8507873811429377341.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1603927/img_id8507873811429377341.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1603927/img_id8507873811429377341.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1603927/img_id8507873811429377341.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1603927/img_id8507873811429377341.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1603927/img_id8507873811429377341.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/7978910/img_id2773560666949528115.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/7978910/img_id2773560666949528115.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/7978910/img_id2773560666949528115.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/7978910/img_id2773560666949528115.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/7978910/img_id2773560666949528115.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/7978910/img_id2773560666949528115.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQsNPTycqVkcN2EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCLjX0GwQ6v3bpvkCGITU0AcgxdjBBw==","sign":"Ap0Mx7cOUz09kPkltr873I1mSzLAkBrSbLvGxZjbwOA="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:227814328_20/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Нафтизин капли наз. фл.-кап., 0.1%, 10 мл

    Цена 18 ₽
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    Реклама
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  • Гилан Комфорт увлажн. гл. р-р, 0.18%, 0.4 мл, 30 шт.
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    Гилан Комфорт увлажн. гл. р-р, 0.18%, 0.4 мл, 30 шт.

    Цена 563 ₽ вместо 569
  • Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.
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    Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.

    Цена 306 ₽ вместо 520
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