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Описание

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Сиофор таб. п/о плен., 1000 мг, 60 шт.

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4.8

(38)

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Коротко о товаре

Артикул Маркета

3123137288

Тип препарата

рецептурный лекарственный препарат

Назначение

сахарный диабет 2 типа

Действующее вещество

Метформин

Возраст

от 10 лет

Инструкция

Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.

Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

Где купить

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209 ₽

Скидка: 13%

–13 %

Вместо:240 ₽

Сегодня, самовывоз • 0 ₽

ЕАПТЕКА

Рейтинг 5 из 5

98Котзывов

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противопоказаний).\u003Cbr\u003E"},{"description":"","filters":[{"id":15768002,"name":"Противопоказания"}],"isMainProperty":false,"name":"Противопоказания","value":"- гиперчувствительность к метформину или вспомогательным веществам препарата;\u003Cbr\u003E- диабетический кетоацидоз, диабетическая прекома, кома;\u003Cbr\u003E- нарушение функции почек (клиренс креатинина \u003C 60 мл/мин);\u003Cbr\u003E- острые состояния, протекающие с риском развития нарушения функции почек: дегидратация (например, при диарее, рвоте), тяжелые инфекционные заболевания, шок;\u003Cbr\u003E- острые или хронические состояния, сопровождающиеся гипоксией тканей (сердечная или дыхательная недостаточность, недавно перенесенный инфаркт миокарда, шок);\u003Cbr\u003E- период в течение 48 ч до начала и 48 ч после проведения радиоизотопных или рентгенологических исследований с введением йодсодержащих рентгеноконтрастных средств (в т.ч. ангиография или урография) (внутривенное введение йодсодержащих рентгеноконтрастных средств может приводить к нарушению функции почек);\u003Cbr\u003E- период в течение 48 ч до начала и 48 ч после проведения хирургических вмешательств;\u003Cbr\u003E- печеночная недостаточность, нарушение функции печени;\u003Cbr\u003E- лактоацидоз (в том числе, в анамнезе);\u003Cbr\u003E- острая алкогольная интоксикация, хронический алкоголизм;\u003Cbr\u003E- соблюдение низкокалорийной диеты (менее 1000 ккал в сутки);\u003Cbr\u003E- детский возраст до 10 лет;\u003Cbr\u003E- беременность."},{"description":"","filters":[{"id":15768292,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"На 1 таблетку:\u003Cbr\u003EЯдро:\u003Cbr\u003EДействующее вещество: метформина гидрохлорид - 500,0 мг, 850,0 мг, 1000,0 мг;\u003Cbr\u003EВспомогательные вещества: гипромеллоза, повидон (значение К = 25), магния стеарат.\u003Cbr\u003EПленочная оболочка: гипромеллоза, макрогол 6000, титана диоксид, Е171."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Метформин"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"(определение концентрации креатинина в плазме крови не менее 2-4 раз в год).\u003Cbr\u003EПациенты с нарушением функции почек\u003Cbr\u003EМетформин может применяться у пациентов с почечной недостаточностью средней степени тяжести (КК 30-59 мл/мин) только в случае отсутствия состояний/факторов риска, которые могут увеличивать риск развития лактоацидоза.\u003Cbr\u003EПациенты с КК 30-44 мл/мин: начальная доза составляет 500 мг 1 раз в сутки.\u003Cbr\u003EМаксимальная суточная доза составляет 1000 мг, разделенная на 2 приема. Для пациентов ' с КК 45-59 мл/мин максимальная суточная доза составляет 2000 мг, разделенная на 2-3 приема, а начальная доза в большинстве случаев - в 2 раза меньше максимальной дозы.\u003Cbr\u003EФункция почек (определение КК) должна оцениваться до начала терапии метформином, а затем не реже 1 раза в год. У пациентов с повышенным риском прогрессирования почечной недостаточности и у пожилых пациентов функцию почек следует контролировать чаще (каждые 3-6 месяцев).\u003Cbr\u003EЕсли КК ниже 30 мл/мин, прием метформина должен быть немедленно прекращен.\u003Cbr\u003E(КК. мл/мин)/ Максимальная суточная доза (разделенная на 2-3 приема)/ Комментарии\u003Cbr\u003E60-89/ 3000 мг/ Доза может быть уменьшена при снижении функции почек.\u003Cbr\u003E45-59/ 2000 мг/ Перед началом терапии метформином следует учесть все увеличивающие риск лактоацидоза. Начальная доза не должна составлять более половины суточной дозы.\u003Cbr\u003E30-44 /1000 мг / Перед началом терапии метформином следует учесть все увеличивающие риск лактоацидоза. Начальная доза не должна составлять более половины суточной дозы.\u003Cbr\u003E\u003C30 - Прием метформина проти зопоказан.\u003Cbr\u003EПродолжительность лечения\u003Cbr\u003EПрепарат Сиофорк 500 следует принимать ежедневно, без перерыва. В случае прекращения лечения пациент должен сообщить об этом врачу.\u003Cbr\u003E"},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Нежелательные реакции, возможные на фоне терапии метформином распределены по системно-органным классам с указанием частоты их возникновения согласно рекомендациям ВОЗ: очень часто (\u003E1/10), часто (\u003E1/100, \u003C1/10), нечасто (\u003E1/1000, \u003C1/100), редко (\u003E1/10000, \u003C1/1000), очень редко (\u003C1/10000), включая отдельные сообщения.\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003EЧасто: нарушение вкуса (металлический привкус во рту).\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr\u003EОчень часто: тошнота, рвота, диарея, боль в животе, отсутствие аппетита.\u003Cbr\u003EЭти нежелательные реакции часто возникают в начале терапии и в большинстве случаев проходят самопроизвольно. Для предотвращения симптомов дозу препарата рекомендуется распределять на 2 -3 приема во время или после основных приемов пищи.\u003Cbr\u003EПостепенное увеличение дозы улучшает переносимость препарата со стороны ЖКТ.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr\u003EОчень редко: кожные реакции, например, эритема, зуд, кожная сыпь.\u003Cbr\u003EНарушения со стороны обмена веществ и питания\u003Cbr\u003EОчень редко: лактоацидоз (требует прекращения лечения). Симптомы лактоацидоза (см. раздел «Особые указания»).\u003Cbr\u003EПри длительном применении наблюдается уменьшение всасывания витамина В12 и снижение его концентрации в плазме крови. Это следует учитывать при наличии у пациента мегалобластной анемии.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей\u003Cbr\u003EОчень редко: обратимые нарушения функции печени, выражающиеся в повышении активности «печеночных» трансаминаз, или гепатит, проходящие после прекращения приема метформина.\u003Cbr\u003EДетский возраст\u003Cbr\u003EСогласно данным, полученым в ходе пострегистрационного применения и результатам контролируемых клинических исследований, при применении метформина в течение 1 года у детей в возрасте 10-16 лет характер и выраженность нежелательных реакций сопоставима с таковыми для взрослых.\u003Cbr\u003E"},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Метформин снижает гипергликемию, не приводя к развитию гипогликемии. В отличие от производных сульфонилмочевины, не стимулирует секрецию инсулийа и не оказывает гипогликемического эффекта у здоровых людей. Повышает чувствительность периферических рецепторов к инсулину и утилизацию глюкозы клетками (особенно в мышечной ткани). Снижает выработку глюкозы печенью за счет ингибирования глюконеогенеза и гликогенолиза. Задерживает всасывание глюкозы в кишечнике.\u003Cbr\u003EМетформин стимулирует синтез гликогена, воздействуя на гликогенсинтетазу.\u003Cbr\u003EУвеличивает транспортную емкость нескольких типов мембранных переносчиков глюкозы. Кроме того, оказывает благоприятный эффект на метаболизм липидов: снижает концентрацию общего холестерина, липопротеинов низкой плотности и триглицеридов.\u003Cbr\u003EНа фоне приема метформина масса тела пациента либо остается стабильной, либо умеренно снижается. Клинические исследования показали также эффективность метформина для профилактики сахарного диабета у пациентов с предиабетом с дополнительными факторами риска развития явного сахарного диабета 2 типа, у которых изменение образа жизни не позволило достичь адекватного гликемического контроля.\u003Cbr\u003E"},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"гипогликемическое средство для перорального применения группы бигуанидов"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 10 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"При температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"При применении метформина в дозе до 85 г (в 42,5 раза превышающей максимальную суточную дозу) развития гипогликемии не наблюдалось. Однако в этом случае наблюдалось развитие лактоацидоза. Значительная передозировка или сопряженные факторы риска могут привести к развитию лактоацидоза (см. раздел «Особые указания»).\u003Cbr\u003EЛечение-, в случае появления признаков лактоацидоза, прием препарата необходимо немедленно прекратить, пациента срочно госпитализировать и, определив концентрацию лактата, уточнить диагноз. Наиболее эффективным мероприятием по выведению из организма лактата и метформина является гемодиализ. Проводят также симптоматическое лечение.\u003Cbr\u003E"},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EПрименение метформина во время беременности противопоказано. Неконтролируемый сахарный диабет во время беременности может приводить к увеличению риска возникновения врожденных аномалий и перинатальной смертности.\u003Cbr\u003EОграниченное количество данных свидельствует о том, что применение метформина у беременных женщин не увеличивает риск развития врожденных пороков у детей.\u003Cbr\u003EПри планировании беременности, а также в случае наступления беременности на фоне приема метформина при предиабете и сахарном диабете 2 типа, применение метформина должно быть прекращено, и в случае сахарного диабета 2 типа - назначена инсулинотерапия. Необходимо поддерживать концентрацию глюкозы в плазме крови на уровне, наиболее близком к норме для снижения риска возникновения пороков развития плода.\u003Cbr\u003EПациентку с сахарным диабетом следует проинформировать о необходимости поставить в известность врача в случае наступления беременности.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EМетформин проникает в грудное молоко. У новорожденных/младенцев, находящихся на грудном вскармливании, матери которых получали метформин; никаких нежелательных реакций на фоне приема метформина не наблюдалось. Однако, учитывая ограниченность данных, применение метформина в период грудного вскармливания не рекомендуется.\u003Cbr\u003EРешение о прекращении грудного вскармливания должно быть принято с учетом пользы от грудного вскармливания и потенциального риска возникновения нежелательных реакций у ребенка.\u003Cbr\u003E"},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Применение препарата Сиофор не вызывает гипогликемию, поэтому не влияет на способность к управлению транспортными средствами и обслуживанию механизмов.\u003Cbr\u003EПри одновременном применении препарата Сиофор с другими гипогликемическими лекарственными средствами (производные сульфонилмочевины, инсулин, репаглинид), возможно развитие гипогликемических состояний, поэтому необходимо соблюдать осторожность при управлении транспортными средствами и другими потенциально опасными видами деятельности, требующих концентрации внимания и быстроты психомоторных реакций.\u003Cbr\u003E\u003Cbr\u003E"},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Лактоацидоз - серьезное патологическое состояние, встречающееся крайне редко, связанное с накоплением в крови лактата, причиной которого может стать кумуляция метформина (симптомы лактоацидоза). Диагностическими лабораторными показателями лактоацидоза являются снижение pH крови менее 7,25, содержание лактата в плазме крови свыше 5 ммоль/л, повышенные анионный промежуток и отношение лактат/пируват. Описанные случаи развития лактоацидоза у пациентов, получавших метформин, наблюдались преимущественно у пациентов с сахарным диабетом с выраженной почечной недостаточностью. Профилактика лактоацидоза предполагает определение всех сопутствующих факторов риска, таких как декомпенсированный сахарный диабет, кетоз, длительное голодание, чрезмерное употребление алкоголя, печеночная недостаточность и любое состояние, связанное с гипоксией. При подозрении на развитие лактоацидоза рекомендуется немедленная отмена препарата и экстренная госпитализация.\u003Cbr\u003EПоскольку метформин выводится почками, при применении препарата Сиофор должен регулярно осуществляться контроль концентрации сывороточного креатинина:\u003Cbr\u003E- не менее одного раза в год у пациентов с нормальной функцией почек;\u003Cbr\u003E- не менее 2-4 раз в год у пациентов с концентрацией сывороточного креатинина близкой к верхней границе нормы, а также у пожилых пациентов.\u003Cbr\u003EОсобую осторожность следует соблюдать в тех случаях, когда возникает риск нарушения функции почек, например, в начале терапии гипотензивными препаратами, диуретиками или нестероидными противовоспалительными препаратами (НПВП).\u003Cbr\u003EЛечение препаратом Сиофор необходимо временно заменить терапией другими гипогликемическими средствами (например, инсулином) в течение 48 ч до и 48 ч после рентгенологического исследования с внутривенным введением йодсодержащих рентгеноконтрастных средств.\u003Cbr\u003EПрименение препарата Сиофор необходимо прекратить в течение 48 ч до плановой хирургической операции под общим наркозом, со спинальной или эпидуральной анестезией. Продолжить терапию следует после возобновления перорального питания или не ранее чем через 48 ч после хирургического вмешательства при условии подтверждения нормальной почечной функции.\u003Cbr\u003EПрепарат Сиофор не заменяет диету и ежедневные физические упражнения - эти виды терапии необходимо сочетать в соответствии с рекомендациями врача. Во время лечения препаратом Сиофор всем пациентам следует придерживаться диетического питания с равномерным потреблением углеводов в течение дня. Пациенты с избыточной массой тела должны соблюдать низкокалорийную диету.\u003Cbr\u003EСтандартные для пациентов с сахарным диабетом лабораторные исследования необходимо проводить регулярно.\u003Cbr\u003EПеред применением препарата Сиофор у детей от 10 до 18 лет следует подтвердить диагноз сахарного диабета 2 типа.\u003Cbr\u003EВ ходе контролируемых клинических исследований продолжительностью 1 год влияния метформина на рост и развитие, а также половое созревание детей не наблюдалось, данные по этим показателям при более длительном применении отсутствуют. В связи с этим рекомендуется тщательный контроль соответствующих параметров у детей, получающих метформин, особенно в препубертатный период (10-12 лет).\u003Cbr\u003EМонотерапия препаратом Сиофор не приводит к гипогликемии, однако рекомендуется соблюдать осторожность при совместном применении препарата с инсулином или производными сульфонилмочевины.\u003Cbr\u003EМетформин не влиял на фертильность самцов или самок крыс при применении в дозах (600 мг/кг/сут), втрое превышающих максимальную рекомендованную суточную дозу для человека.\u003Cbr\u003EС осторожностью:\u003Cbr\u003E- детский возраст от 10 до 12 лет;\u003Cbr\u003E- период грудного вскармливания;\u003Cbr\u003E- лица старше 60 лет, выполняющие тяжелую физическую работу (повышенная опасность развития лактоацидоза).\u003Cbr\u003E"},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Противопоказанные комбинации\u003Cbr\u003EЙодсодержащие рентгеноконтрастные средства: на фоне функциональной почечной\u003Cbr\u003Eнедостаточности у пациентов с сахарным диабетом радиологическое исследование с применением йодсодержащих рентгеноконтрастных средств может вызывать развитие лактоацидоза. Лечение метформином необходимойотменить в зависимости от функции почек за 48 ч до или на время рентгенологического исследования с применением йодсодержащих рентгеноконтрастных средств и не возобновлять ранее 48 ч после, при условии, что в ходе обследования не было выявлено ухудшения функции почек.\u003Cbr\u003EНерекомендуемые комбинации\u003Cbr\u003EАлкоголь: при острой алкогольной интоксикации увеличивается риск развития лактоацидоза, особенно в случае:\u003Cbr\u003E- недостаточного питания, соблюдения низкокалорийной диеты;\u003Cbr\u003E- печеночной недостаточности.\u003Cbr\u003EВо время приема препарата следует избегать приема алкоголя и лекарственных средств, содержащих этанол.\u003Cbr\u003EКомбинации, требующие осторожности\u003Cbr\u003EДаназол: не рекомендуется одновременный прием даназола во избежание гипергликемического действия последнего. При необходимости лечения даназолом и после прекращения приема последнего требуется коррекция дозы метформина под контролем концентрации глюкозы в крови.\u003Cbr\u003EХлорпромазин: при приеме в больших дозах (100 мг в день) повышает концентрацию глюкозы в крови, снижая высвобождение инсулина. При лечении нейролептиками и после прекращения приема последних требуется коррекция дозы препарата под контролем концентрации глюкозы в крови.\u003Cbr\u003EГлюкокортикостероиды (ГКС) системного и местного действия снижают толерантность к глюкозе, повышают концентрацию глюкозы в крови, иногда вызывая кетоз. Во время терапии ГКС и после ее прекращения требуется коррекция дозы метформина под контролем концентрации глюкозы в крови.\u003Cbr\u003EДиуретики: одновременный прием «петлевых» диуретиков может привести к развитию лактоацидоза из-за возможной функциональной почечной недостаточности. Не следует начинать терапию метформином при КК менее 60 мл/мин.\u003Cbr\u003EИнъекционные формы бетаз-адреномиметиков: повышают концентрацию глюкозы в\u003Cbr\u003Eкрови вследствие стимуляции бетаг-адренорецепторов. В этом случае необходим контроль концентрации глюкозы в крови. При необходимости рекомендуется назначение инсулина.\u003Cbr\u003EПри одновременном применении вышеперечисленных лекарственных средств может потребоваться более частый контроль концентрации глюкозы в крови, особенно в начале лечения. При необходимости доза метформина может быть скорректирована в процессе лечения и после его прекращения.\u003Cbr\u003EГипотензивные лекарственные средства, за исключением ингибиторови ангиотензинпревращающего фермента, могут снижать концентрацию глюкозы в крови.\u003Cbr\u003EПри необходимости следует скорректировать дозу метформина.\u003Cbr\u003EПри одновременном применении метформина с производными сульфонилмочевины, инсулином, акарбозой, салицилатами возможно развитие гипогликемии.\u003Cbr\u003EНифедипин повышает абсорбцию и С mах метформина.\u003Cbr\u003EКатионные лекарственные средства (амилорид, дигоксин, морфин, прокаинамид, хинидин, хинин, ранитидин, триамтерен, триметоприм и ванкомицин), секретирующиеся в почечных канальцах, конкурируют с метформином за канальцевые транспортные системы и могут приводить к увеличению его Сmах.\u003Cbr\u003EТранспортеры органических катионов (ОСТ)\u003Cbr\u003EМетформин является субстратом обоих транспортеров ОСТ1 и ОСТ2.\u003Cbr\u003EОдновременное применение метформина с:\u003Cbr\u003E- ингибиторами ОСТ1 (верапамил) может уменьшать эффективность метформина; - индукторами ОСТ1 (рифампицин) может увеличивать абсорбцию метформина в ЖКТ и его эффективность;\u003Cbr\u003E- ингибиторами ОСТ2 (циметидин, долутегравир, ранолазин, триметоприм, кризотиниб, олапариб, даклатасвир, вандетаниб) могут уменьшать почечную элиминацию метформина и таким образом приводить к увеличению плазменной концентрации метформина.\u003Cbr\u003EВ связи с этим рекомендуется соблюдать осторожность, особенно у пациентов с почечной недостаточностью, когда эти лекарственные препараты принимаются одновременно с метформином, так как возможно повышение плазменной концентрации метформина. При необходимости может быть рассмотрен вопрос о коррекции дозы метформина, так как ингибиторы/индукторы ОСТ могут изменять эффективность метформина.\u003Cbr\u003EНекоторые лекарственные средства способны оказывать гипергликемическое действие и приводить к ухудшению гликемического контроля. К таким лекарственным средствам относятся фенотиазиды, глюкагон, эстрогены, пероральные контрацептивы, фенитоин, симпатомиметики, никотиновая кислота, изониазид, блокаторы «медленных» кальциевых каналов, гормоны щитовидной железы. 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Инструкция

Показания к применению

Сахарный диабет 2 типа, особенно у пациентов с избыточной массой тела, для контроля концентрации глюкозы в плазме крови.
- у взрослых в качестве монотерапии или в составе комбинированной терапии с другими пероральными гипогликемическими средствами и/или инсулином.
- у детей старше 10 лет в качестве монотерапии или в комбинации с инсулином.
Лечение сахарного диабета 2 типа должно сопровождаться коррекцией диеты и повышением физической активности (при отсутствии противопоказаний).

Противопоказания

- гиперчувствительность к метформину или вспомогательным веществам препарата;
- диабетический кетоацидоз, диабетическая прекома, кома;
- нарушение функции почек (клиренс креатинина < 60 мл/мин);
- острые состояния, протекающие с риском развития нарушения функции почек: дегидратация (например, при диарее, рвоте), тяжелые инфекционные заболевания, шок;
- острые или хронические состояния, сопровождающиеся гипоксией тканей (сердечная или дыхательная недостаточность, недавно перенесенный инфаркт миокарда, шок);
- период в течение 48 ч до начала и 48 ч после проведения радиоизотопных или рентгенологических исследований с введением йодсодержащих рентгеноконтрастных средств (в т.ч. ангиография или урография) (внутривенное введение йодсодержащих рентгеноконтрастных средств может приводить к нарушению функции почек);
- период в течение 48 ч до начала и 48 ч после проведения хирургических вмешательств;
- печеночная недостаточность, нарушение функции печени;
- лактоацидоз (в том числе, в анамнезе);
- острая алкогольная интоксикация, хронический алкоголизм;
- соблюдение низкокалорийной диеты (менее 1000 ккал в сутки);
- детский возраст до 10 лет;
- беременность.

Способ применения и дозы

(определение концентрации креатинина в плазме крови не менее 2-4 раз в год).
Пациенты с нарушением функции почек
Метформин может применяться у пациентов с почечной недостаточностью средней степени тяжести (КК 30-59 мл/мин) только в случае отсутствия состояний/факторов риска, которые могут увеличивать риск развития лактоацидоза.
Пациенты с КК 30-44 мл/мин: начальная доза составляет 500 мг 1 раз в сутки.
Максимальная суточная доза составляет 1000 мг, разделенная на 2 приема. Для пациентов ' с КК 45-59 мл/мин максимальная суточная доза составляет 2000 мг, разделенная на 2-3 приема, а начальная доза в большинстве случаев - в 2 раза меньше максимальной дозы.
Функция почек (определение КК) должна оцениваться до начала терапии метформином, а затем не реже 1 раза в год. У пациентов с повышенным риском прогрессирования почечной недостаточности и у пожилых пациентов функцию почек следует контролировать чаще (каждые 3-6 месяцев).
Если КК ниже 30 мл/мин, прием метформина должен быть немедленно прекращен.
(КК. мл/мин)/ Максимальная суточная доза (разделенная на 2-3 приема)/ Комментарии
60-89/ 3000 мг/ Доза может быть уменьшена при снижении функции почек.
45-59/ 2000 мг/ Перед началом терапии метформином следует учесть все увеличивающие риск лактоацидоза. Начальная доза не должна составлять более половины суточной дозы.
30-44 /1000 мг / Перед началом терапии метформином следует учесть все увеличивающие риск лактоацидоза. Начальная доза не должна составлять более половины суточной дозы.
<30 - Прием метформина проти зопоказан.
Продолжительность лечения
Препарат Сиофорк 500 следует принимать ежедневно, без перерыва. В случае прекращения лечения пациент должен сообщить об этом врачу.

Полная инструкция

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Сиофор таб. п/о плен., 1000 мг, 60 шт.

4.8

(38)

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5 вопросов

Инструкция

209 ₽

Скидка: 13%

–13 %

Вместо:240 ₽

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4.8

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У продавца:38 оценок·4 отзыва

У всех продавцов:291 оценка·63 отзыва

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6 месяцев назад • Вадим Германович Тартачев • Куплен на Маркете

Достоинства: читайте внимательно инструкцию , рекомендации врача

6 месяцев назад • Игорь В. • Куплен на Маркете

Достоинства: Берлин хими
Недостатки: Не обнаружил
Комментарий: Пользуюсь ими давно, все ок

4 месяца назад • Vladimir Iukaev • Куплен на Маркете

Достоинства: Хорошее лекарство

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Рекомендуем

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Розувастатин таб. п/о плен., 5 мг, 30 шт.

Цена 207 ₽ вместо 257

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Валсартан-СЗ таб. п/о плен., 80 мг, 30 шт.

Цена 264 ₽ вместо 314

{"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401075609_11/content/content/toggleWishlist":{"skuId":"186858033","productId":1401075609,"offerId":"qRBWF4G8vw9zlc02B0TKfg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ88Ldvc3X8bN9EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCJnvipwFELH0jFkYycv1ByDX3MEH","sign":"95p28dSFLLKsL42sB2ehILj4IS7tK5KOpXfdC8CcvQg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401075609_11/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

Лозап таб. п/о плен., 100 мг, 30 шт.

Цена 209 ₽

{"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401075592_12/content/content/toggleWishlist":{"skuId":"228004076","productId":1401075592,"offerId":"9kyVvI7gZcH-bFX9LEdtxA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ88Ldvc3X8bN9EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCIjvipwFEOyh3GwYtNWHBCDX3MEH","sign":"UpZtrvMs9xm00FO8OQly7SV2guM/7hxsDFfSAqQb/Ok="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401075592_12/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

Бисопролол таб. п/о плен., 5 мг, 30 шт.

Цена 105 ₽

{"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:856233048_13/content/content/toggleWishlist":{"skuId":"101733248850","productId":856233048,"offerId":"mO8akhCgPlNcaSnq84NWCg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ88Ldvc3X8bN9EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCNiopJgDENLemP76AhjozocEINfcwQc=","sign":"E8Vvo2X6yI0KkOEgFJ6R3ujLwaIrPhNSDxaTdwIKKuo="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:856233048_13/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

Конкор таб. п/о плен., 5 мг, 30 шт.

Цена 219 ₽ вместо 269

{"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401075427_14/content/content/toggleWishlist":{"skuId":"186910723","productId":1401075427,"offerId":"-y81h-Lkpjhgdkj6cGXT2A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ88Ldvc3X8bN9EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCOPtipwFEIOQkFkYrt7QByDX3MEH","sign":"6WQy98z7A/3+KnxSrm7DUGlx1XBbQAic0uwjOtNy5C8="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401075427_14/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

Розувастатин-СЗ таб. п/о плен., 20 мг, 30 шт.

Цена 292 ₽

{"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401075472_15/content/content/toggleWishlist":{"skuId":"186609925","productId":1401075472,"offerId":"jGro40HCw6opMZRJNqlbHQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ88Ldvc3X8bN9EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCJDuipwFEIXi/VgYrt7QByDX3MEH","sign":"y11/q1qjlOs+/lar0RjcSvft0t/9Mtel4u/kWuPO9QI="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1401075472_15/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

Аторвастатин-СЗ таб. п/о плен., 10 мг, 30 шт.

Цена 136 ₽

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Метформин-Тева таб. п/о плен., 1000 мг, 60 шт.

Цена 195 ₽

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Сиофор таб. п/о плен., 850 мг, 60 шт.

Цена 174 ₽

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Трипликсам таб. п/о плен., 5 мг+2.5 мг+10 мг, 30 шт.

Цена 1 146 ₽

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Олиджим таб., 30 г, 100 шт.

Цена 508 ₽ вместо 599

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Эдарби Кло таб. п/о плен., 40 мг+25 мг, 28 шт.

Цена 1 236 ₽ вместо 1 565

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Метформин Санофи таб. п/о плен., 500 мг, 60 шт.

Цена 105 ₽ вместо 155

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Бисопролол таб. п/о плен., 2.5 мг, 30 шт.

Цена 85 ₽

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Описание

Сиофор таб. п/о плен., 1000 мг, 60 шт.

Коротко о товаре

Где купить

209 ₽

Глюкофаж Лонг таб. пролонг. действ., 750 мг, 30 шт.

Глюкофаж лонг таб. пролонг. действ., 1000 мг, 30 шт.

Метформин таб., 1000 мг, 60 шт.

Метформин-Тева таб. п/о плен., 1000 мг, 60 шт.

Сиофор таб. п/о плен., 850 мг, 60 шт.

Олиджим таб., 30 г, 100 шт.

Метформин Санофи таб. п/о плен., 500 мг, 60 шт.

Глюкофаж Лонг таб. пролонг. действ., 500 мг, 60 шт.

Метформин-ВЕРТЕКС таб. п/о плен., 850 мг, 60 шт.

Метформин Канон таб. п/о плен., 1000 мг, 60 шт.

Мерифатин таб. п/о плен., 500 мг, 60 шт.

Диабетон МВ таб. модиф. высвоб., 60 мг, 30 шт.

Инструкция

Показания к применению

Противопоказания

Способ применения и дозы

209 ₽

Рекомендуем

Верошпирон таб., 25 мг, 20 шт.

Эдарби таб., 20 мг, 28 шт.

Глюкофаж Лонг таб. пролонг. действ., 750 мг, 30 шт.

Небиволол-СЗ таб., 5 мг, 28 шт.

Глюкофаж лонг таб. пролонг. действ., 1000 мг, 30 шт.

L-Тироксин Берлин-Хеми таб., 125 мкг, 100 шт.

Беталок зок таб. с замедл. высвоб. п/о, 50 мг, 30 шт.

Метформин таб., 1000 мг, 60 шт.

Розувастатин таб. п/о плен., 5 мг, 30 шт.

Валсартан-СЗ таб. п/о плен., 80 мг, 30 шт.

Лозап таб. п/о плен., 100 мг, 30 шт.

Бисопролол таб. п/о плен., 5 мг, 30 шт.

Конкор таб. п/о плен., 5 мг, 30 шт.

Розувастатин-СЗ таб. п/о плен., 20 мг, 30 шт.

Аторвастатин-СЗ таб. п/о плен., 10 мг, 30 шт.

Метформин-Тева таб. п/о плен., 1000 мг, 60 шт.

Сиофор таб. п/о плен., 850 мг, 60 шт.

Трипликсам таб. п/о плен., 5 мг+2.5 мг+10 мг, 30 шт.

Олиджим таб., 30 г, 100 шт.

Эдарби Кло таб. п/о плен., 40 мг+25 мг, 28 шт.

Метформин Санофи таб. п/о плен., 500 мг, 60 шт.

Бисопролол таб. п/о плен., 2.5 мг, 30 шт.

209 ₽

209 ₽