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Применение препарата у пациентов с заболеваниями, указанными в разделе \"С осторожностью\", возможно только после консультации врача."},{"description":"","filters":[{"id":15768292,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"Каждая таблетка, покрытая пленочной оболочкой, содержит:Активное вещество: цитизин 1,5 мг.\u003Cbr\u003EВспомогательные вещества: лактозы моногидрат (28,0 мг), целлюлоза микрокристаллическая (67,5 мг), тальк (2,0 мг), магния стеарат (1,0 мг).\u003Cbr\u003E Состав пленочного покрытия: опадрай II коричневый 85F 26948 (3,0 мг): поливиниловый спирт частично гидролизованный - 1,2 мг; титана диоксид (Е 171)- 0,654 мг; макрогол 3350 - 0,606 мг; тальк - 0,444 мг; железа оксид желтый (Е 172) - 0,062 мг, железа оксид красный(Е 172) - 0,018 мг, железа оксид черный (Е 172)-0,016 мг."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Цитизин"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Таблетки принимают внутрь целиком, запивая достаточным количеством жидкости.\u003Cbr\u003EНе следует превышать рекомендованные дозы.\u003Cbr\u003EПрием препарата желательно начинать после установки пациента на полный отказ от курения.\u003Cbr\u003EПрепарат следует применять по следующей схеме: с 1 по 3 день - по 1 таблетке 6 раз/сут каждые 2 часа, постепенно сокращая число выкуренных сигарет.\u003Cbr\u003EТаблетку следует принимать между эпизодами курения для удлинения интервалов между выкуриванием сигарет, чтобы максимально снизить их потребление. Интервал приема каждые 2 ч должен соблюдаться.\u003Cbr\u003EЕсли не удается добиться снижения суточного потребления сигарет, лечение следует прекратить и через 2-3 месяца можно начать его снова.\u003Cbr\u003EПри хорошем эффекте лечение продолжают по следующей схеме:\u003Cbr\u003Eс 4 по 12 день приема - по 1 таблетке 5 раз/сут, каждые 2.5 часа;\u003Cbr\u003Eс 13 по 16 день - по 1 таблетке 4 раза/сут, каждые 3 часа;\u003Cbr\u003Eс 17 по 20 день - по 1 таблетке 3 раза/сут, каждые 5 часов;\u003Cbr\u003Eс 21 по 25 день - по 1-2 таблетке в сутки.\u003Cbr\u003EНастоятельно рекомендуется отказаться от курения не позднее 5 дня от начала лечения.\u003Cbr\u003EСочетание медикаментозной терапии с консультациями, в т.ч. с мерами психологической поддержки пациента, достоверно повышает эффективность лечения."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Проведенные клинические исследования и постмаркетинговые наблюдения показывают хорошую переносимость препарата. Наблюдаемые побочные реакции выражены слабо или умеренно. Большинство из них наступает в начале лечения, и проходят самостоятельно. Чаще всего они связаны с отказом от табакокурения и проявляются головокружением, головной болью и бессонницей.\u003Cbr\u003EВ рекомендованных дозах препарат Табекс не вызывает серьезных неблагоприятных эффектов.\u003Cbr\u003EВозможны следующие побочные реакции.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: тахикардия, незначительное повышение АД, ощущение сердцебиения.\u003Cbr\u003EСо стороны ЦНС: головная боль, головокружение, бессонница или сонливость, повышенная раздражительность.\u003Cbr\u003EСо стороны дыхательной системы: одышка.\u003Cbr\u003EСо стороны ЖКТ: сухость во рту, тошнота, боли в животе, запоры, диарея, изменения вкуса и аппетита.\u003Cbr\u003EСо стороны костно-мышечной и соединительной ткани: боли в мышцах.\u003Cbr\u003EСо стороны обмена веществ и питания: снижение массы тела, повышенное потоотделение.\u003Cbr\u003EПрочие: боли в грудной клетке."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Алкалоид цитизин является активным веществом препарата, обладает н-холиномиметическим действием. Его эффекты выражаются в следующем: возбуждает ганглии вегетативной нервной системы, рефлекторно возбуждает дыхание, вызывает выделение адреналина из мозгового вещества надпочечников, повышает артериальное давление.\nПри близком сходстве с механизмом действия никотина, цитизин обладает гораздо более низкой токсичностью и бо́льшим терапевтическим индексом. Цитизин конкурентно подавляет взаимодействие никотина с соответствующими рецепторами, что ведет к постепенному уменьшению и исчезновению никотиновой (табачной) зависимости.\u003Cbr\u003EФармакокинетика.Фармакокинетические параметры цитизина исследованы у 36 здоровых добровольцев после перорального применения однократной дозы 1,5 мг (1 таблетка Табекс).\u003Cbr\u003EВсасывание.Цитизин быстро всасывается из желудочно-кишечного тракта после его перорального применения. Максимальная концентрация препарата в плазме крови составляет 15,55 нг/мл и достигается в течение 0,92 ч.\u003Cbr\u003EРаспределение.Клинические данные о распределении препарата у людей отсутствуют. У мышей высокие плазменные концентрации цитизина после перорального и внутривенного применения устанавливаются в печени, почках и надпочечниках. Объем распределения (Vd) у кроликов после перорального и внутривенного применения составляет 6,21 л/кг и соответственно 1,02 л/кг.\u003Cbr\u003EБиотрансформация и выведение.Цитизин не метаболизируется в организме. До 64 % примененной дозы выводится в неизмененном виде с мочой в пределах 24 ч. Период полувыведения составляет приблизительно 4 ч. Среднее время удержания (MRT) цитизина в организме составляет приблизительно 6 ч."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"средство лечения никотиновой зависимости"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"},{"description":"","filters":[{"id":16382542,"name":"Подробная комплектация"}],"isMainProperty":false,"name":"Комплектация","value":"с календарем"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Препарат следует хранить в сухом, защищенном от света месте при температуре не выше 25°C.\u003Cbr\u003EХранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Симптомы: тошнота, рвота, расширение зрачков, общая слабость, тахикардия, клонические судороги, паралич дыхания. Симптомы передозировки наступают в случае, когда пациент не соблюдает режим дозирования и принимает препарат в дозах, в несколько раз превышающие терапевтические.\u003Cbr\u003EПри передозировке необходимо немедленно обратиться к врачу!\u003Cbr\u003EЛечение: прием активированного угля, промывание желудка, инфузионное введение водно-солевых растворов, а также 5% или 10 % раствора глюкозы, противосудорожные средства, кардиотоники, дыхательные аналептики и другие симптоматические средства. Следует отслеживать работу органов дыхания, АД и ЧСС."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Табекс не следует применять женщинам во время беременности и в период грудного вскармливания."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Хотя на фоне применения препарата какого-либо отрицательного влияния на способность управлять автотранспортом и работу с механизмами не наблюдалось, вследствие возможного возникновения сонливости и других побочных реакций следует соблюдать осторожность в перечисленных ситуациях."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Препарат следует применять только в том случае, если пациент имеет серьезное намерение отказаться от курения.\u003Cbr\u003EЛицам с длительным стажем курения и лицам старше 40-45 лет препарат Табекс следует применять только после консультации с врачом.\u003Cbr\u003EПри применении препарата не следует превышать рекомендованные дозы.\u003Cbr\u003EЛечение препаратом и продолжение курения может привести к усилению побочного действия никотина (никотиновая интоксикация).\u003Cbr\u003EПрепарат содержит вспомогательное вещество лактозу. Пациентам с редкими наследственными проблемами непереносимости галактозы, с лактазным дефицитом (Lapp) или глюкозо-галактозной мальабсорбцией не следует применять Табекс."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"После прекращения табакокурения могут усиливаться побочные эффекты теофиллина, ропинирола, клозапина и оланзапина.\u003Cbr\u003EПри одновременном применении препарата Табекс с ацетилхолином, карбахолом, галантамином, пиридостигмином, ривастигмином, дистигмином возможно усиление холиномиметических побочных эффектов (слюнотечение, слезотечение, бронхиальная секреция с кашлем и риск возникновения приступа астмы, сужение зрачка, колики, тошнота, рвота, частое мочеиспускание, повышенный тонус мышц или внезапные сокращения мышц).\u003Cbr\u003EПрименение препарата Табекс одновременно ловастатином, симвастатином, флувастатином, правастатином и др. повышает риск появления болей в 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началом применения препарата);\u003Cbr\u003E— атеросклероз;\u003Cbr\u003E— тяжелая артериальная гипертензия;\u003Cbr\u003E— беременность;\u003Cbr\u003E— период грудного вскармливания;\u003Cbr\u003E— возраст до 18 лет;\u003Cbr\u003E— пациенты старше 65 лет;\u003Cbr\u003E— недостаточность лактазы, галактоземия, синдром мальабсорбции глюкозы-галактозы (в состав препарата входит лактоза).\u003Cbr\u003EС осторожностью следует применять препарат Табекс при других формах ИБС (стабильная стенокардия, бессимптомная (тихая) ишемия миокарда, вазоспастическая стенокардия, синдром \"X\" (микрососудистая стенокардия)), при сердечной недостаточности, повышенном АД, при заболеваниях сосудов головного мозга, облитерирующих артериальных заболеваниях, гипертиреоидизме, при язвенной болезни желудка, при сахарном диабете, почечной или печеночной недостаточности, при некоторых формах шизофрении, при наличии хромаффинных опухолей надпочечников, гастроэзофагеальной рефлюксной болезни, лицам с длительным стажем курения и лицам старше 40-45 лет. Применение препарата у пациентов с заболеваниями, указанными в разделе \"С осторожностью\", возможно только после консультации врача."},{"description":"","filters":[{"id":15768292,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"Каждая таблетка, покрытая пленочной оболочкой, содержит:Активное вещество: цитизин 1,5 мг.\u003Cbr\u003EВспомогательные вещества: лактозы моногидрат (28,0 мг), целлюлоза микрокристаллическая (67,5 мг), тальк (2,0 мг), магния стеарат (1,0 мг).\u003Cbr\u003E Состав пленочного покрытия: опадрай II коричневый 85F 26948 (3,0 мг): поливиниловый спирт частично гидролизованный - 1,2 мг; титана диоксид (Е 171)- 0,654 мг; макрогол 3350 - 0,606 мг; тальк - 0,444 мг; железа оксид желтый (Е 172) - 0,062 мг, железа оксид красный(Е 172) - 0,018 мг, железа оксид черный (Е 172)-0,016 мг."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Цитизин"},{"description":"","filters":[{"id":34025894,"name":"Дозировка"}],"isMainProperty":false,"name":"Дозировка","value":"1.5 мг"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Таблетки принимают внутрь целиком, запивая достаточным количеством жидкости.\u003Cbr\u003EНе следует превышать рекомендованные дозы.\u003Cbr\u003EПрием препарата желательно начинать после установки пациента на полный отказ от курения.\u003Cbr\u003EПрепарат следует применять по следующей схеме: с 1 по 3 день - по 1 таблетке 6 раз/сут каждые 2 часа, постепенно сокращая число выкуренных сигарет.\u003Cbr\u003EТаблетку следует принимать между эпизодами курения для удлинения интервалов между выкуриванием сигарет, чтобы максимально снизить их потребление. Интервал приема каждые 2 ч должен соблюдаться.\u003Cbr\u003EЕсли не удается добиться снижения суточного потребления сигарет, лечение следует прекратить и через 2-3 месяца можно начать его снова.\u003Cbr\u003EПри хорошем эффекте лечение продолжают по следующей схеме:\u003Cbr\u003Eс 4 по 12 день приема - по 1 таблетке 5 раз/сут, каждые 2.5 часа;\u003Cbr\u003Eс 13 по 16 день - по 1 таблетке 4 раза/сут, каждые 3 часа;\u003Cbr\u003Eс 17 по 20 день - по 1 таблетке 3 раза/сут, каждые 5 часов;\u003Cbr\u003Eс 21 по 25 день - по 1-2 таблетке в сутки.\u003Cbr\u003EНастоятельно рекомендуется отказаться от курения не позднее 5 дня от начала лечения.\u003Cbr\u003EСочетание медикаментозной терапии с консультациями, в т.ч. с мерами психологической поддержки пациента, достоверно повышает эффективность лечения."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Проведенные клинические исследования и постмаркетинговые наблюдения показывают хорошую переносимость препарата. Наблюдаемые побочные реакции выражены слабо или умеренно. Большинство из них наступает в начале лечения, и проходят самостоятельно. Чаще всего они связаны с отказом от табакокурения и проявляются головокружением, головной болью и бессонницей.\u003Cbr\u003EВ рекомендованных дозах препарат Табекс не вызывает серьезных неблагоприятных эффектов.\u003Cbr\u003EВозможны следующие побочные реакции.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: тахикардия, незначительное повышение АД, ощущение сердцебиения.\u003Cbr\u003EСо стороны ЦНС: головная боль, головокружение, бессонница или сонливость, повышенная раздражительность.\u003Cbr\u003EСо стороны дыхательной системы: одышка.\u003Cbr\u003EСо стороны ЖКТ: сухость во рту, тошнота, боли в животе, запоры, диарея, изменения вкуса и аппетита.\u003Cbr\u003EСо стороны костно-мышечной и соединительной ткани: боли в мышцах.\u003Cbr\u003EСо стороны обмена веществ и питания: снижение массы тела, повышенное потоотделение.\u003Cbr\u003EПрочие: боли в грудной клетке."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Алкалоид цитизин является активным веществом препарата, обладает н-холиномиметическим действием. Его эффекты выражаются в следующем: возбуждает ганглии вегетативной нервной системы, рефлекторно возбуждает дыхание, вызывает выделение адреналина из мозгового вещества надпочечников, повышает артериальное давление.\nПри близком сходстве с механизмом действия никотина, цитизин обладает гораздо более низкой токсичностью и бо́льшим терапевтическим индексом. Цитизин конкурентно подавляет взаимодействие никотина с соответствующими рецепторами, что ведет к постепенному уменьшению и исчезновению никотиновой (табачной) зависимости.\u003Cbr\u003EФармакокинетика.Фармакокинетические параметры цитизина исследованы у 36 здоровых добровольцев после перорального применения однократной дозы 1,5 мг (1 таблетка Табекс).\u003Cbr\u003EВсасывание.Цитизин быстро всасывается из желудочно-кишечного тракта после его перорального применения. Максимальная концентрация препарата в плазме крови составляет 15,55 нг/мл и достигается в течение 0,92 ч.\u003Cbr\u003EРаспределение.Клинические данные о распределении препарата у людей отсутствуют. У мышей высокие плазменные концентрации цитизина после перорального и внутривенного применения устанавливаются в печени, почках и надпочечниках. Объем распределения (Vd) у кроликов после перорального и внутривенного применения составляет 6,21 л/кг и соответственно 1,02 л/кг.\u003Cbr\u003EБиотрансформация и выведение.Цитизин не метаболизируется в организме. До 64 % примененной дозы выводится в неизмененном виде с мочой в пределах 24 ч. Период полувыведения составляет приблизительно 4 ч. Среднее время удержания (MRT) цитизина в организме составляет приблизительно 6 ч."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"средство лечения никотиновой зависимости"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"},{"description":"","filters":[{"id":16382542,"name":"Подробная комплектация"}],"isMainProperty":false,"name":"Комплектация","value":"с календарем"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Препарат следует хранить в сухом, защищенном от света месте при температуре не выше 25°C.\u003Cbr\u003EХранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Симптомы: тошнота, рвота, расширение зрачков, общая слабость, тахикардия, клонические судороги, паралич дыхания. Симптомы передозировки наступают в случае, когда пациент не соблюдает режим дозирования и принимает препарат в дозах, в несколько раз превышающие терапевтические.\u003Cbr\u003EПри передозировке необходимо немедленно обратиться к врачу!\u003Cbr\u003EЛечение: прием активированного угля, промывание желудка, инфузионное введение водно-солевых растворов, а также 5% или 10 % раствора глюкозы, противосудорожные средства, кардиотоники, дыхательные аналептики и другие симптоматические средства. Следует отслеживать работу органов дыхания, АД и ЧСС."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Табекс не следует применять женщинам во время беременности и в период грудного вскармливания."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Хотя на фоне применения препарата какого-либо отрицательного влияния на способность управлять автотранспортом и работу с механизмами не наблюдалось, вследствие возможного возникновения сонливости и других побочных реакций следует соблюдать осторожность в перечисленных ситуациях."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Препарат следует применять только в том случае, если пациент имеет серьезное намерение отказаться от курения.\u003Cbr\u003EЛицам с длительным стажем курения и лицам старше 40-45 лет препарат Табекс следует применять только после консультации с врачом.\u003Cbr\u003EПри применении препарата не следует превышать рекомендованные дозы.\u003Cbr\u003EЛечение препаратом и продолжение курения может привести к усилению побочного действия никотина (никотиновая интоксикация).\u003Cbr\u003EПрепарат содержит вспомогательное вещество лактозу. 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