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Урорек капс., 8 мг, 90 шт.

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4.9
(7)
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Дозировка: 8 мг

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Количество штук в упаковке, шт.: 90

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Коротко о товаре

Артикул Маркета
3288332681
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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Необходимо проглатывать капсулу целиком, желательно запивать стаканом воды.\u003Cbr\u003EПациенты с нарушением функции почек:\u003Cbr\u003EУ пациентов с легкой почечной недостаточностью (клиренс креатинина ≥ 50-\u003C80 мл/мин) коррекция дозы не требуется. Для лечения пациентов с почечной недостаточностью средней степени тяжести (клиренс креатинина ≥ 30 до \u003C50 мл / мин) рекомендуется в течение первой недели принимать начальную дозу по 4 мг в сутки, при хорошей индивидуальной переносимости доза может быть увеличена до 8 мг в сутки. Применение препарата для пациентов с тяжелой почечной недостаточностью (клиренс креатинина \u003C 30 мл / мин) не рекомендуется.\u003Cbr\u003EПациенты с нарушенной функцией печени:\u003Cbr\u003EДля пациентов с легкой печеночной недостаточностью и с печеночной недостаточностью средней степени тяжести коррекция дозы не требуется. Из-за отсутствия данных, применение препарата для пациентов с тяжелой печеночной недостаточностью не рекомендуется\u003Cbr\u003EПожилые пациенты:\u003Cbr\u003EДля пожилых людей коррекция дозы не требуется.\u003Cbr\u003EПрименение у детей:\u003Cbr\u003EСоответствующего применения препарата Урорек в педиатрической практике по показаниям к применению не было."},{"name":"Побочные действия","value":"Ниже перечислены нежелательные побочные реакции, отмеченные во всех клинических исследованиях и на протяжении международного постмаркетингового опыта применения, в отношении которых существует причинная взаимосвязь, согласно классификации MedDRA в соответствии с поражением органов и систем органов и частотой развития: очень часто (≥1/10), часто (от ≥ 1/100до \u003C 1/10), нечасто (от ≥ 1/1000 до \u003C 1/100), редко (от ≥1/10 000 до \u003C 1/1000), очень редко (от \u003C 1/10 000), частота неизвестна (частота не может быть определена по доступным данным).\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EОчень редко: аллергические реакции: ангионевротический отек лица, языка и гортани*.\u003Cbr\u003EНарушения психики\u003Cbr\u003EНечасто: снижение либидо.\u003Cbr\u003EНарушения со стороны нервнойсистемы\u003Cbr\u003EЧасто: головокружение, редко: потеря сознания*, частота неизвестна: синкопе.\u003Cbr\u003EНарушения со стороны сердца\u003Cbr\u003EНечасто: тахикардия*, редко: ощущение сердцебиения*.\u003Cbr\u003EНарушения со стороны сосудов\u003Cbr\u003EЧасто: ортостатическая гипотензия, нечасто: снижение артериального давления*.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003Cbr\u003EЧасто: заложенность носа.\u003Cbr\u003EНарушения со стороны желудочно- кишечного тракта\u003Cbr\u003EЧасто: диарея, нечасто: тошнота, сухость во рту.\u003Cbr\u003EНарушения со стороны гепатобилиарной системы\u003Cbr\u003EНечасто: отклонение от нормы показателей функции печени*.\u003Cbr\u003EНарушения со стороны кожи и подкожной клетчатки\u003Cbr\u003EНечасто: сыпь*, кожный зуд*, крапивница*, лекарственный дерматит*.\u003Cbr\u003EНарушения со стороны половых органов и молочной железы\u003Cbr\u003EОчень часто: ретроградная эякуляция, анэякуляция, нечасто: эректильная дисфункция.\u003Cbr\u003EТравмы, отравления и осложнения процедур\u003Cbr\u003EЧастота неизвестна: интраоперационный синдром \"дряблой\" радужки во время операций поповоду катаракты.\u003Cbr\u003E* - побочные эффекты, зарегистрированные спонтанно в ходе международного постмаркетингового опыта применения (частота встречаемости была рассчитана исходя из встречаемости явлений в ходе клинических исследований I-IV фаз и неинтервенционных исследований).\u003Cbr\u003EОртостатическая гипотензия: частота ортостатической гипотензии в плацебо-контролируемых клинических исследованиях составила 1,2 % в группе, принимающей силодозин и 1,0 % в группе, принимающей плацебо.\u003Cbr\u003EОртостатическая гипотензия иногда может стать причиной обморока.\u003Cbr\u003EИнтраоперационный синдром дряблой радужки (ИС ДР):\u003Cbr\u003EСообщалось о развитии ИСДР во время операции по удалению катаракты\u003Cbr\u003EЕсли любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."},{"name":"Фармакологическое действие","value":"Силодозин, высокоселективный конкурентный антагонист альфа1А- адренорецепторов, которые в основном расположены в предстательной железе, в тканях дна и шейки мочевого пузыря, капсуле предстательной железы и простатической части мочеиспускательного канала.\u003Cbr\u003EБлокада альфа1А-адренорецепторов снижает тонус гладкой мускулатуры в этих тканях, что ведет к улучшению оттока мочи из мочевого пузыря. Одновременно уменьшаются симптомы обструкции и раздражения, связанные с доброкачественной гиперплазией предстательной железы. В исследованиях in vitro было показано, что сродство силодозина к альфа1А -адренорецепторам в 162 раза превосходит его способность взаимодействовать с альфа1В-адрено- рецепторами, которые расположены в гладких мышцах сосудов. Благодаря высокой селективности силодозин не вызывает клинически значимого снижения артериального давления (АД) у пациентов с исходно нормальным АД."},{"name":"Фармакологическая группа","value":"простаты гиперплазии доброкачественной средство лечения"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["35947170:36763744"]}}},{"name":"Пол","value":"для мужчин","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["14805991:14805992"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °C в оригинальной упаковке (блистер в пачке картонной). Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Силодозин оценивался в дозе до 48 мг/день у здоровых мужчин. Дозозависимой нежелательной реакцией была постуральная гипотензия. При недавнем приеме внутрь возможна инициация рвоты или промывание желудка. Если передозировка препарата Урорек привела к гипотензии, необходимо провести меры по поддержке сердечно-сосудистой системы пациента. Маловероятно, что диализ даст существенные результаты, так как силодозин активно связывается с белком крови (96,6 %)."},{"name":"Применение при беременности и кормлении грудью","value":"Силодозин предназначен только для мужчин."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не проводилось исследований влияния на способность управлять транспортными средствами и оборудованием. Однако пациентов следует информировать о возможности появления симптомов, связанных с ортостатической гипотензией (например, головокружения), а также предупредить о том, что следует воздержаться от управления транспортными средствами и оборудованием до выяснения индивидуальной переносимости препарата Урорек пациентом."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПри легкой и умеренной почечной недостаточности (клиренс креатинина от 30 до 50 мл/мин).\u003Cbr\u003EКак и при применении других альфа1-адреноблокаторов при лечении силодозином может наблюдаться снижение АД, ортостатическая гипотензия. Пациентам с ортостатической гипотензией в анамнезе не рекомендуется принимать силодозин. При первых признаках ортостатической гипотензии (головокружение, слабость) пациент должен сесть или лечь и оставаться в этом положении до тех пор, пока симптомы ортостатической гипотензии не исчезнут.\u003Cbr\u003EПоскольку доброкачественная гиперплазия предстательной железы и злокачественная опухоль предстательной железы имеют сходные симптомы и могут развиваться вместе, пациентам с подозрением на доброкачественную гиперплазию предстательной железы перед назначением препарата необходимо обследование для исключения злокачественной опухоли предстательной железы.\u003Cbr\u003EПальцевое ректальное исследование и, при необходимости, определение простатического специфического антигена (ПСА) должны быть выполнены до начала лечения и через регулярные промежутки времени после него.\u003Cbr\u003EЛечение силодозином может приводить к уменьшению выделяемого количества семенной жидкости во время оргазма, что может временно сказаться на мужской фертильности. Этот эффект исчезает после прекращения приема силодозина.\u003Cbr\u003EУ пациентов, принимающих или принимавших альфа1-адреноблокаторы, во время операции по поводу катаракты может возникать интраоперационный синдром \"дряблой\" радужки (ИСДР), что может привести к осложнениям во время операции. Пациентам, у которых запланирована операция по поводу катаракты, не рекомендуется начинать лечение силодозином. Рекомендуется прекращение лечения альфа1-адреноблокаторами за 1-2 недели до такой операции, но преимущества и продолжительность прекращения терапии до операции по удалению катаракты еще не установлены.\u003Cbr\u003EПри предварительной оценке перед операцией хирурги и офтальмологи должны учитывать - принимали или принимают силодозин пациенты, у которых запланирована данная операция, для принятия соответствующих мер по ведению и контролю ИСДР."},{"name":"Взаимодействие","value":"Силодозин активно метаболизируется, главным образом, посредством CYP3A4, алкоголь-дегидрогеназы и UGT2B7. Силодозин также является субстратом для Р-гликопротеина. Вещества, которые ингибируют или индуцируют эти ферменты и переносчики, могут влиять на концентрацию силодозина и его активного метаболита в плазме.\u003Cbr\u003EАльфа-блокаторы\u003Cbr\u003EДостаточной информации о безопасности совместного приема силодозина и других альфа-адреноблокаторов нет. Поэтому одновременный прием других антагонистов альфа-адренорецепторов не рекомендуется.\u003Cbr\u003EИнгибиторы CYP3A4\u003Cbr\u003EВ исследовании взаимодействия было обнаружено 3,7-кратное повышение максимальной концентрации силодозина в плазме и 3,1-кратное усиление воздействия силодозина (т.е. AUC) при одновременном введении сильнодействующего ингибитора CYP3A4 (кетоконазол 400 мг). Одновременное применение с мощными ингибиторами CYP3A4 (такими как кетоконазол, итраконазоли ритонавир) не рекомендуется.\u003Cbr\u003EПри совместном приеме силодозина и умеренного ингибитора CYP3A4, например, дилтиазема, наблюдалось приблизительно 30 % увеличение AUC силодозина, но на значения Сmах и период полувыведения влияния не было. Это изменение не является клинически важным, коррекция дозы не требуется.\u003Cbr\u003EИнгибиторы фосфодиэстеразы (ФДЭ) 5-го типа\u003Cbr\u003EМежду силодозином и максимальной дозой силденафила или тадалафила наблюдалось только минимальное фармакодинамическое взаимодействие. В плацебо-контролируемом исследовании у 24 человек в возрасте 45-78 лет, получавших силодозин, одновременное назначение силденафила 100 мг или тадалафила 20 мг вызвало клинически не значимое среднее снижение систолического или диастолического артериального давления, что оценивалось при проведении ортостатической пробы (разница пульса лежа и стоя). У пациентов старше 65 лет среднее снижение в различные моменты времени было между 5 и 15 мм рт.ст. (систолическое) и между 0 и 10 мм рт.ст. (диастолическое). Положительные результаты ортостатических проб были лишь незначительно более частыми во время совместного приема препаратов, однако, симптоматического ортостаза или головокружения не было зафиксировано. Состояние пациентов, одновременно получающих ингибиторы ФДЭ-5 и препарат, должно контролироваться на возможное развитие нежелательных реакций.\u003Cbr\u003EГипотензивные средства\u003Cbr\u003EВ соответствии с программой клинического исследования многие пациенты получали сопутствующую терапию гипотензивными средствами (в основном, средствами, воздействующими на ренин-ангиотензиновую систему, бета-блокаторами, антагонистами кальция и диуретиками) без повышения частоты ортостатической гипотензии. Тем не менее, необходимо принимать меры предосторожност при одновременном применении препарата с гипотензивными средствами. Состояние пациентов должно контролироваться на возможное развитие нежелательных реакций.\u003Cbr\u003EДигоксин\u003Cbr\u003EПри одновременном приеме силодозина 8 мг один раз в день не было отмечено существенного влияния на плато концентраций дигоксина, субстрата Р-гликопротеина. Коррекция дозы не требуется."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛСР-005971/10"},{"name":"Дата государственной регистрации","value":"04.02.2022"},{"name":"Владелец регистрационного удостоверения","value":"RECORDATI Industria Chimica e Farmaceutica, S.p.A.","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["34324371:35649313","7893318:17861284"]}}},{"name":"Изготовитель","value":"Laboratoires Bouchara Recordati"},{"name":"Фасовщик","value":"Laboratoires Bouchara Recordati"},{"name":"Страна-производитель","value":"Италия"},{"name":"Название препарата","value":"Урорек","transition":{"type":"catalog","params":{"categorySlug":"mochepolovaia-sistema-i-polovye-gormony","categoryId":"15756910","navnodeId":"72506","glfilters":["17796364:18036915"]}}},{"name":"Срок годности","value":"36 мес."}]}},"fullSpecsGrouped":{"10316724477972944404":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"половая система"},{"name":"Назначение","value":"доброкачественная гиперплазия предстательной железы"},{"name":"Показания к применению","value":"Доброкачественная гиперплазия предстательной железы."},{"name":"Противопоказания","value":"- гиперчувствительность к активному веществу или любому из вспомогательных компонентов или их непереносимость;\u003Cbr\u003E- дети до 18 лет;\u003Cbr\u003E- тяжелая почечная недостаточность (клиренс креатинина менее 30 мл/мин);\u003Cbr\u003E- тяжелая печеночная недостаточность (недостаточно клинических данных)."},{"name":"Состав","value":"1 капсула 4 мг содержит:\u003Cbr\u003EДействующее вещество: силодозин 4 мг.\u003Cbr\u003EВспомогательные вещества: маннитол, крахмал прежелатинизированный (PCS™ PC-10), крахмал прежелатинизированный (Starch 1500™), натрия лаурилсульфат, магния стеарат.\u003Cbr\u003EСостав желатиновой капсулы: желатин, титана диоксид, краситель железа оксид желтый (Е172).\u003Cbr\u003E1 капсула 8 мг содержит:\u003Cbr\u003EДействующее вещество: силодозин 8 мг.\u003Cbr\u003EВспомогательные вещества: маннитол, крахмал прежелатинизированный (PCS™ РС- 10), крахмал прежелатинизированный (Starch 1500™), натрия лаурилсульфат, магния стеарат.\u003Cbr\u003EСостав желатиновой капсулы: желатин, титана диоксид."},{"name":"Действующее вещество","value":"Силодозин"},{"name":"Способ применения и дозы","value":"Рекомендуемая доза - 8 мг однократно, одновременно с приемом пищи, предпочтительно в одно и тоже время суток. Необходимо проглатывать капсулу целиком, желательно запивать стаканом воды.\u003Cbr\u003EПациенты с нарушением функции почек:\u003Cbr\u003EУ пациентов с легкой почечной недостаточностью (клиренс креатинина ≥ 50-\u003C80 мл/мин) коррекция дозы не требуется. Для лечения пациентов с почечной недостаточностью средней степени тяжести (клиренс креатинина ≥ 30 до \u003C50 мл / мин) рекомендуется в течение первой недели принимать начальную дозу по 4 мг в сутки, при хорошей индивидуальной переносимости доза может быть увеличена до 8 мг в сутки. Применение препарата для пациентов с тяжелой почечной недостаточностью (клиренс креатинина \u003C 30 мл / мин) не рекомендуется.\u003Cbr\u003EПациенты с нарушенной функцией печени:\u003Cbr\u003EДля пациентов с легкой печеночной недостаточностью и с печеночной недостаточностью средней степени тяжести коррекция дозы не требуется. Из-за отсутствия данных, применение препарата для пациентов с тяжелой печеночной недостаточностью не рекомендуется\u003Cbr\u003EПожилые пациенты:\u003Cbr\u003EДля пожилых людей коррекция дозы не требуется.\u003Cbr\u003EПрименение у детей:\u003Cbr\u003EСоответствующего применения препарата Урорек в педиатрической практике по показаниям к применению не было."},{"name":"Побочные действия","value":"Ниже перечислены нежелательные побочные реакции, отмеченные во всех клинических исследованиях и на протяжении международного постмаркетингового опыта применения, в отношении которых существует причинная взаимосвязь, согласно классификации MedDRA в соответствии с поражением органов и систем органов и частотой развития: очень часто (≥1/10), часто (от ≥ 1/100до \u003C 1/10), нечасто (от ≥ 1/1000 до \u003C 1/100), редко (от ≥1/10 000 до \u003C 1/1000), очень редко (от \u003C 1/10 000), частота неизвестна (частота не может быть определена по доступным данным).\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EОчень редко: аллергические реакции: ангионевротический отек лица, языка и гортани*.\u003Cbr\u003EНарушения психики\u003Cbr\u003EНечасто: снижение либидо.\u003Cbr\u003EНарушения со стороны нервнойсистемы\u003Cbr\u003EЧасто: головокружение, редко: потеря сознания*, частота неизвестна: синкопе.\u003Cbr\u003EНарушения со стороны сердца\u003Cbr\u003EНечасто: тахикардия*, редко: ощущение сердцебиения*.\u003Cbr\u003EНарушения со стороны сосудов\u003Cbr\u003EЧасто: ортостатическая гипотензия, нечасто: снижение артериального давления*.\u003Cbr\u003EНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003Cbr\u003EЧасто: заложенность носа.\u003Cbr\u003EНарушения со стороны желудочно- кишечного тракта\u003Cbr\u003EЧасто: диарея, нечасто: тошнота, сухость во рту.\u003Cbr\u003EНарушения со стороны гепатобилиарной системы\u003Cbr\u003EНечасто: отклонение от нормы показателей функции печени*.\u003Cbr\u003EНарушения со стороны кожи и подкожной клетчатки\u003Cbr\u003EНечасто: сыпь*, кожный зуд*, крапивница*, лекарственный дерматит*.\u003Cbr\u003EНарушения со стороны половых органов и молочной железы\u003Cbr\u003EОчень часто: ретроградная эякуляция, анэякуляция, нечасто: эректильная дисфункция.\u003Cbr\u003EТравмы, отравления и осложнения процедур\u003Cbr\u003EЧастота неизвестна: интраоперационный синдром \"дряблой\" радужки во время операций поповоду катаракты.\u003Cbr\u003E* - побочные эффекты, зарегистрированные спонтанно в ходе международного постмаркетингового опыта применения (частота встречаемости была рассчитана исходя из встречаемости явлений в ходе клинических исследований I-IV фаз и неинтервенционных исследований).\u003Cbr\u003EОртостатическая гипотензия: частота ортостатической гипотензии в плацебо-контролируемых клинических исследованиях составила 1,2 % в группе, принимающей силодозин и 1,0 % в группе, принимающей плацебо.\u003Cbr\u003EОртостатическая гипотензия иногда может стать причиной обморока.\u003Cbr\u003EИнтраоперационный синдром дряблой радужки (ИС ДР):\u003Cbr\u003EСообщалось о развитии ИСДР во время операции по удалению катаракты\u003Cbr\u003EЕсли любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."},{"name":"Фармакологическое действие","value":"Силодозин, высокоселективный конкурентный антагонист альфа1А- адренорецепторов, которые в основном расположены в предстательной железе, в тканях дна и шейки мочевого пузыря, капсуле предстательной железы и простатической части мочеиспускательного канала.\u003Cbr\u003EБлокада альфа1А-адренорецепторов снижает тонус гладкой мускулатуры в этих тканях, что ведет к улучшению оттока мочи из мочевого пузыря. Одновременно уменьшаются симптомы обструкции и раздражения, связанные с доброкачественной гиперплазией предстательной железы. В исследованиях in vitro было показано, что сродство силодозина к альфа1А -адренорецепторам в 162 раза превосходит его способность взаимодействовать с альфа1В-адрено- рецепторами, которые расположены в гладких мышцах сосудов. Благодаря высокой селективности силодозин не вызывает клинически значимого снижения артериального давления (АД) у пациентов с исходно нормальным АД."},{"name":"Фармакологическая группа","value":"простаты гиперплазии доброкачественной средство лечения"},{"name":"Форма выпуска","value":"капсулы"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Пол","value":"для мужчин"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"Хранить при температуре не выше 25 °C в оригинальной упаковке (блистер в пачке картонной). Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Силодозин оценивался в дозе до 48 мг/день у здоровых мужчин. Дозозависимой нежелательной реакцией была постуральная гипотензия. При недавнем приеме внутрь возможна инициация рвоты или промывание желудка. Если передозировка препарата Урорек привела к гипотензии, необходимо провести меры по поддержке сердечно-сосудистой системы пациента. Маловероятно, что диализ даст существенные результаты, так как силодозин активно связывается с белком крови (96,6 %)."},{"name":"Применение при беременности и кормлении грудью","value":"Силодозин предназначен только для мужчин."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не проводилось исследований влияния на способность управлять транспортными средствами и оборудованием. Однако пациентов следует информировать о возможности появления симптомов, связанных с ортостатической гипотензией (например, головокружения), а также предупредить о том, что следует воздержаться от управления транспортными средствами и оборудованием до выяснения индивидуальной переносимости препарата Урорек пациентом."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EПри легкой и умеренной почечной недостаточности (клиренс креатинина от 30 до 50 мл/мин).\u003Cbr\u003EКак и при применении других альфа1-адреноблокаторов при лечении силодозином может наблюдаться снижение АД, ортостатическая гипотензия. Пациентам с ортостатической гипотензией в анамнезе не рекомендуется принимать силодозин. При первых признаках ортостатической гипотензии (головокружение, слабость) пациент должен сесть или лечь и оставаться в этом положении до тех пор, пока симптомы ортостатической гипотензии не исчезнут.\u003Cbr\u003EПоскольку доброкачественная гиперплазия предстательной железы и злокачественная опухоль предстательной железы имеют сходные симптомы и могут развиваться вместе, пациентам с подозрением на доброкачественную гиперплазию предстательной железы перед назначением препарата необходимо обследование для исключения злокачественной опухоли предстательной железы.\u003Cbr\u003EПальцевое ректальное исследование и, при необходимости, определение простатического специфического антигена (ПСА) должны быть выполнены до начала лечения и через регулярные промежутки времени после него.\u003Cbr\u003EЛечение силодозином может приводить к уменьшению выделяемого количества семенной жидкости во время оргазма, что может временно сказаться на мужской фертильности. Этот эффект исчезает после прекращения приема силодозина.\u003Cbr\u003EУ пациентов, принимающих или принимавших альфа1-адреноблокаторы, во время операции по поводу катаракты может возникать интраоперационный синдром \"дряблой\" радужки (ИСДР), что может привести к осложнениям во время операции. Пациентам, у которых запланирована операция по поводу катаракты, не рекомендуется начинать лечение силодозином. Рекомендуется прекращение лечения альфа1-адреноблокаторами за 1-2 недели до такой операции, но преимущества и продолжительность прекращения терапии до операции по удалению катаракты еще не установлены.\u003Cbr\u003EПри предварительной оценке перед операцией хирурги и офтальмологи должны учитывать - принимали или принимают силодозин пациенты, у которых запланирована данная операция, для принятия соответствующих мер по ведению и контролю ИСДР."},{"name":"Взаимодействие","value":"Силодозин активно метаболизируется, главным образом, посредством CYP3A4, алкоголь-дегидрогеназы и UGT2B7. Силодозин также является субстратом для Р-гликопротеина. Вещества, которые ингибируют или индуцируют эти ферменты и переносчики, могут влиять на концентрацию силодозина и его активного метаболита в плазме.\u003Cbr\u003EАльфа-блокаторы\u003Cbr\u003EДостаточной информации о безопасности совместного приема силодозина и других альфа-адреноблокаторов нет. Поэтому одновременный прием других антагонистов альфа-адренорецепторов не рекомендуется.\u003Cbr\u003EИнгибиторы CYP3A4\u003Cbr\u003EВ исследовании взаимодействия было обнаружено 3,7-кратное повышение максимальной концентрации силодозина в плазме и 3,1-кратное усиление воздействия силодозина (т.е. AUC) при одновременном введении сильнодействующего ингибитора CYP3A4 (кетоконазол 400 мг). Одновременное применение с мощными ингибиторами CYP3A4 (такими как кетоконазол, итраконазоли ритонавир) не рекомендуется.\u003Cbr\u003EПри совместном приеме силодозина и умеренного ингибитора CYP3A4, например, дилтиазема, наблюдалось приблизительно 30 % увеличение AUC силодозина, но на значения Сmах и период полувыведения влияния не было. Это изменение не является клинически важным, коррекция дозы не требуется.\u003Cbr\u003EИнгибиторы фосфодиэстеразы (ФДЭ) 5-го типа\u003Cbr\u003EМежду силодозином и максимальной дозой силденафила или тадалафила наблюдалось только минимальное фармакодинамическое взаимодействие. В плацебо-контролируемом исследовании у 24 человек в возрасте 45-78 лет, получавших силодозин, одновременное назначение силденафила 100 мг или тадалафила 20 мг вызвало клинически не значимое среднее снижение систолического или диастолического артериального давления, что оценивалось при проведении ортостатической пробы (разница пульса лежа и стоя). У пациентов старше 65 лет среднее снижение в различные моменты времени было между 5 и 15 мм рт.ст. (систолическое) и между 0 и 10 мм рт.ст. (диастолическое). Положительные результаты ортостатических проб были лишь незначительно более частыми во время совместного приема препаратов, однако, симптоматического ортостаза или головокружения не было зафиксировано. Состояние пациентов, одновременно получающих ингибиторы ФДЭ-5 и препарат, должно контролироваться на возможное развитие нежелательных реакций.\u003Cbr\u003EГипотензивные средства\u003Cbr\u003EВ соответствии с программой клинического исследования многие пациенты получали сопутствующую терапию гипотензивными средствами (в основном, средствами, воздействующими на ренин-ангиотензиновую систему, бета-блокаторами, антагонистами кальция и диуретиками) без повышения частоты ортостатической гипотензии. Тем не менее, необходимо принимать меры предосторожност при одновременном применении препарата с гипотензивными средствами. Состояние пациентов должно контролироваться на возможное развитие нежелательных реакций.\u003Cbr\u003EДигоксин\u003Cbr\u003EПри одновременном приеме силодозина 8 мг один раз в день не было отмечено существенного влияния на плато концентраций дигоксина, субстрата Р-гликопротеина. Коррекция дозы не требуется."},{"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"name":"Регистрационный номер","value":"ЛСР-005971/10"},{"name":"Дата государственной регистрации","value":"04.02.2022"},{"name":"Владелец регистрационного удостоверения","value":"RECORDATI Industria Chimica e Farmaceutica, S.p.A."},{"name":"Изготовитель","value":"Laboratoires Bouchara Recordati"},{"name":"Фасовщик","value":"Laboratoires Bouchara Recordati"},{"name":"Страна-производитель","value":"Италия"},{"name":"Название препарата","value":"Урорек"},{"name":"Срок годности","value":"36 мес."}]}],"transitionId":"tr_2613031359802277743"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Рейтинг товара: 4.7 из 5
    на основе 17 оценок
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    Цена с картой Яндекс Пэй 389 ₽ вместо 397
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капс., 60 г, 60 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    Рейтинг товара: 4.7 из 5
    на основе 107 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 355 ₽ вместо 359
    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  • Диунорм капс., 30 шт., 1 уп.
    –1 %
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    Диунорм капс., 30 шт., 1 уп.

    Рейтинг товара: 4.5 из 5
    на основе 22 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 054 ₽ вместо 1 065
    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  • Урокомплекс СВ капс., 55 г, 60 шт., 1 уп.
    –39 %
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    Урокомплекс СВ капс., 55 г, 60 шт., 1 уп.

    Рейтинг товара: 4.7 из 5
    на основе 14 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 271 ₽ вместо 2 317
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  • Милона- таб., 100 шт.
    –2 %
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    Милона- таб., 100 шт.

    Рейтинг товара: 4.9 из 5
    на основе 7 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 452 ₽ вместо 462
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  • Уринал Нефро капс., 60 шт.
    –2 %
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    Уринал Нефро капс., 60 шт.

    Рейтинг товара: 4.8 из 5
    на основе 13 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 614 ₽ вместо 1 646
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  • Уростил фл., 50 мл, 142 г, 1 шт., 1 уп.
    –8 %
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    Уростил фл., 50 мл, 142 г, 1 шт., 1 уп.

    Цена 4 200 ₽ вместо 4 550
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  • Уронекст пор. д/приема внутрь г саше, 14 шт., 1 уп.
    –10 %
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    Уронекст пор. д/приема внутрь г саше, 14 шт., 1 уп.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 437 ₽ вместо 1 467
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  • Простаблисс ВА таб., 100 г, 60 шт., нейтральный, 1 уп.
    –27 %
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    Простаблисс ВА таб., 100 г, 60 шт., нейтральный, 1 уп.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 831 ₽ вместо 2 860
    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  • Профилапрост капс., 0.4 г, 60 шт.
    –1 %
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-zkij13wj5vn/toggleWishlist":{"skuId":"101625595757","productId":1699594270,"offerId":"Mvmr0NA8eQCligC6DYoQvw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6KXmvO3vyvYMEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhcInoC3qgYQ7Y7uyvoCGPLThxEg7tzBBw==","sign":"58orycIRlnoSF3hZw4YeROJ39ZfK/wnY51SMqJxEmXg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-zkij13wj5vn/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Профилапрост капс., 0.4 г, 60 шт.

    Рейтинг товара: 4.8 из 5
    на основе 76 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 2 153 ₽ вместо 2 175
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  • Нерей для мужчин форте пантовые супп., 15 шт.
    ВАМ–37 %
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    Нерей для мужчин форте пантовые супп., 15 шт.

    Рейтинг товара: 4.7 из 5
    на основе 153 оценки
    Цена 1 330 ₽ вместо 2 100
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Инструкция

Показания к применению

Доброкачественная гиперплазия предстательной железы.

Противопоказания

- гиперчувствительность к активному веществу или любому из вспомогательных компонентов или их непереносимость;
- дети до 18 лет;
- тяжелая почечная недостаточность (клиренс креатинина менее 30 мл/мин);
- тяжелая печеночная недостаточность (недостаточно клинических данных).

Способ применения и дозы

Рекомендуемая доза - 8 мг однократно, одновременно с приемом пищи, предпочтительно в одно и тоже время суток. Необходимо проглатывать капсулу целиком, желательно запивать стаканом воды.
Пациенты с нарушением функции почек:
У пациентов с легкой почечной недостаточностью (клиренс креатинина ≥ 50-<80 мл/мин) коррекция дозы не требуется. Для лечения пациентов с почечной недостаточностью средней степени тяжести (клиренс креатинина ≥ 30 до <50 мл / мин) рекомендуется в течение первой недели принимать начальную дозу по 4 мг в сутки, при хорошей индивидуальной переносимости доза может быть увеличена до 8 мг в сутки. Применение препарата для пациентов с тяжелой почечной недостаточностью (клиренс креатинина < 30 мл / мин) не рекомендуется.
Пациенты с нарушенной функцией печени:
Для пациентов с легкой печеночной недостаточностью и с печеночной недостаточностью средней степени тяжести коррекция дозы не требуется. Из-за отсутствия данных, применение препарата для пациентов с тяжелой печеночной недостаточностью не рекомендуется
Пожилые пациенты:
Для пожилых людей коррекция дозы не требуется.
Применение у детей:
Соответствующего применения препарата Урорек в педиатрической практике по показаниям к применению не было.
Полная инструкция
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Урорек капс.
Урорек капс., 8 мг, 90 шт.
4.9
(7)
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2 вопроса
Инструкция

2 342 ₽

Скидка: 11%
–11 %
Вместо:2 632 ₽
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4.9
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У продавца:7 оценок·2 отзыва
У всех продавцов:118 оценок·37 отзывов
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user avatar
8 месяцев назад • Сергей Вовк • Куплен на Маркете
Достоинства: Да
Недостатки: Нет
Комментарий: Все хорошо
user avatar
Месяц назад • Pavel S. • Куплен на Маркете
Достоинства: работает
Посмотреть все отзывы на Маркете
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    Цена 355 ₽ вместо 700
  • Нафтизин капли наз. фл.-кап., 0.1%, 10 мл
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    Нафтизин капли наз. фл.-кап., 0.1%, 10 мл

    Цена 18 ₽
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 1 752 ₽ вместо 3 500
  • Фенибут таб., 250 мг, 10 шт.
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    Фенибут таб., 250 мг, 10 шт.

    Цена 92 ₽
  • Лимфомиозот капли д/вн. приема, 30 мл
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    Лимфомиозот капли д/вн. приема, 30 мл

    Цена 910 ₽ вместо 1 081
  • Средство для повышения тестостерона «ALPHAMAN», aTech nutrition, 90 капсул
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:745716413_7/content/content/gallery":{"title":"Средство для повышения тестостерона «ALPHAMAN», aTech nutrition, 90 капсул","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/1859495/img_id2778251054264847198.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1859495/img_id2778251054264847198.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1859495/img_id2778251054264847198.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1859495/img_id2778251054264847198.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1859495/img_id2778251054264847198.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1859495/img_id2778251054264847198.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/11562667/2a0000018f37e5c6357ed46a7f7b48131962/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/11562667/2a0000018f37e5c6357ed46a7f7b48131962/120x160 120w, https://avatars.mds.yandex.net/get-mpic/11562667/2a0000018f37e5c6357ed46a7f7b48131962/180x240 180w, https://avatars.mds.yandex.net/get-mpic/11562667/2a0000018f37e5c6357ed46a7f7b48131962/240x320 240w, https://avatars.mds.yandex.net/get-mpic/11562667/2a0000018f37e5c6357ed46a7f7b48131962/300x400 300w, https://avatars.mds.yandex.net/get-mpic/11562667/2a0000018f37e5c6357ed46a7f7b48131962/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6KXmvO3vyvYMEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCL31yuMCEOfsqc74AhiXpekGIICQ5gY=","sign":"KECWUxBcZZtsyQ6aagXLGtygD1fbBn54V7GHKNyHb20="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:745716413_7/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Средство для повышения тестостерона «ALPHAMAN», aTech nutrition, 90 капсул

    Цена 833 ₽ вместо 1 508
  • {"widgets":{"@light/BannerCurtain":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content/bannerCurtain":{"advertisementId":2127201,"impression":"/safeclick/data=SpQw45JhDGE6zDtOdUQO_MnUNQJ8olRgRnoYl7BJOzY3Snj8I5FlhbwgJUqcBCNHrFUYdSYsPXGjD6FzJVuVagSbsrPf3SfQyT02YXWfe91W1Cilyx7-PWF6PejpBY7qejDZSLoN7abESjKSLIoqsvRbaOnyClGH9ZhSavLkL3xep2q-saSQMRMKF5ESH-gNsMfspz7fllg6SrbJLYp51Z6ohymQa-_I5L7lrtD9rHCigiGq5OLl5lCfeIaDtp1dIViJpmBWGkMcecYItu8D7Oka_PTGe45C40SqT_-Suy01ZxZvENtt_P9_yTWTahZ5arcKyFvPtopqF63dm2f_N9PAG1mD7hIiSUZ7tqv2mjLqaO8vrOAQti-vSLgF7_OYll4RSwUFhkoNCqrtqKu2woABezC0jTRS_MQ6pEK1QiruRnPG_-qGh9DFFNfPcg1shBHeOE-xoAYoT2D38raAR6QX82MDKF3xz4I2Vfw-h4KE_NZ7o-RZXRvzECLFOE-fZkSFjHDbv8TBf5zeBQheAksT6ul0_OQwk42TIleeiXLkCUtzHXYXeZyJ6JG6t_QhsMU0qBWqE3ChXNw7kNpuwu5eh6oXKvo0kQfHEi3BVoFWQEhnavxyHe831ZFb-3JitCg7Q3QCcJw1CoRuF-W2SZsDyErw2MRLt3lVjd0bvpZC254viPWIcjYwtAh9lGeyi8BRv-KZ3GGs_yt1XG53HGu1KAsYgeMpwfuUIlL7RBQb8VhbybQPKlJt8lak5dMzxynLYkLR0F92lLIrxPAS4tNFHXVULzJdGr8lkQpRpN3lqot5EyRH3O1LX99XPrjtzptI-NUAZ7-6KEFlrLKRvX3zXV0osDGgOxYaWAir7izykm9fGc-UCUHsRnBDMkqQr68C8wHAyF4_W0wvfDlQi9cpnD2yeBhY1eZUYT3X8VbY-_Ne8e8NEIxsoQkd5Cc5vtf01HAu1GHhUmUS-N4a4azSP_1hl_IVQfYmfsjwvziA2jBTfPVtt-jBvcaMo-00XVLeYQ3ykxHBE-bLElr8bDxcR5AHXRBcM9lTF6imHnkRnv3i5YCZfOwb8_GHde0t-WBAZwHeU1o4hn2XQ4aKlQ,,/b64e=1/sign=0c98a9c33414922f253596111d8eb64d/keyno=MARKET_1/*"}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content/bannerCurtain":{"name":"@light/BannerCurtain"}}}
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    Реклама
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  • Domix Green лак д/ногтей Стоп грибок, 20 г, 17 мл, 1 уп.
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    Domix Green лак д/ногтей Стоп грибок, 20 г, 17 мл, 1 уп.

    Цена 394 ₽ вместо 792
  • California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.
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    California Gold Nutrition Silymarin Complex капс., 20 г, 120 шт., нейтральный, 1 уп.

    Цена 1 103 ₽ вместо 1 581
  • Милона- таб., 100 шт.
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    Милона- таб., 100 шт.

    Цена 452 ₽ вместо 462
  • Уростил фл., 50 мл, 142 г, 1 шт., 1 уп.
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    Уростил фл., 50 мл, 142 г, 1 шт., 1 уп.

    Цена 4 200 ₽ вместо 4 550
  • Урокомплекс СВ капс., 55 г, 60 шт., 1 уп.
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    Урокомплекс СВ капс., 55 г, 60 шт., 1 уп.

    Цена 2 271 ₽ вместо 3 700
  • Уронекст пор. д/приема внутрь г саше, 14 шт., 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778176041_14/content/content/toggleWishlist":{"skuId":"102601768924","productId":1778176041,"offerId":"YzzIpVDRBgLUPXnOnekkgQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ6KXmvO3vyvYMEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCKmg888GENz/qpz+Ahif5qMHIO7cwQc=","sign":"92GEYFL4zvyOG9EdoafkZbt9F2B/0TvrEqNlKI+YpaI="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778176041_14/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Уронекст пор. д/приема внутрь г саше, 14 шт., 1 уп.

    Цена 1 437 ₽ вместо 1 601
  • Бустер тестостерона Экдистерон 400 мг, БАД Ecdysterone-S 30 порций акмед средство, препарат, натуральный, тестостерон, для потенции, тестобустер, бустер тестостерона, эффективный, форте, для повышения, мышцы, масса, при эректильной дисфункции, для мужчин
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    Бустер тестостерона Экдистерон 400 мг, БАД Ecdysterone-S 30 порций акмед средство, препарат, натуральный, тестостерон, для потенции, тестобустер, бустер тестостерона, эффективный, форте, для повышения, мышцы, масса, при эректильной дисфункции, для мужчин

    Цена 1 862 ₽ вместо 2 659
  • Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.
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    Акваназаль Софт аэр., 150 мл, 120 г, 1 шт., 1 уп.

    Цена 306 ₽ вместо 520
  • Кленбутерол Софарма таб., 0.02 мг, 50 шт.
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    Кленбутерол Софарма таб., 0.02 мг, 50 шт.

    Цена 686 ₽
  • Профилапрост капс., 0.4 г, 60 шт.
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    Профилапрост капс., 0.4 г, 60 шт.

    Цена 2 153 ₽ вместо 2 175
  • Артурон, натуральный бустер тестостерона с цинком, пажитником и d-аспарагиновой кислотой, 50 капсул
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    Артурон, натуральный бустер тестостерона с цинком, пажитником и d-аспарагиновой кислотой, 50 капсул

    Цена 844 ₽ вместо 1 165
  • Декспантенол мазь д/нар. прим., 5%, 25 г
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    Декспантенол мазь д/нар. прим., 5%, 25 г

    Цена 84 ₽ вместо 85
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    Реклама
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  • Простаблисс ВА таб., 100 г, 60 шт., нейтральный, 1 уп.
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    Простаблисс ВА таб., 100 г, 60 шт., нейтральный, 1 уп.

    Цена 2 831 ₽ вместо 3 900
  • Уринал Нефро капс., 60 шт.
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    Уринал Нефро капс., 60 шт.

    Цена 1 614 ₽ вместо 1 646
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