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Зеркалин Интенсив гель д/нар. прим., 50 мг+10 мг/г, 30 мл, 25 г

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Коротко о товаре

Артикул Маркета
4453226760
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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Препарат следует наносить тонким слоем с помощью кончиков пальцев на всю пораженную область 1 раз в сутки вечером на чистую и сухую кожу, избегая попадания геля в глаза, на губы, слизистые оболочки.\u003Cbr\u003EПри необходимости после впитывания геля можно использовать увлажняющее средство. При возникновении сухости кожи или шелушения следует сократить частоту применения геля, либо временно приостановить лечение. Эффективность препарата при частоте применения реже 1 раза в день не была изучена.\u003Cbr\u003EБолее частое, чем рекомендуется инструкцией, нанесение геля не повышает эффективность лечения, но может повысить риск возникновения раздражения кожи.\u003Cbr\u003EСредняя длительность курса лечения, необходимая для достижения терапевтического эффекта, составляет от 2 до 5 недель. Продолжительность лечения должна устанавливаться врачом на основании клинического состояния пациента.\u003Cbr\u003EБезопасность и эффективность применения комбинации клиндамицина и бензоила пероксида при лечении акне длительностью более 12 недель не были изучены. Следует тщательно оценить ожидаемую пользу для пациента при назначении лечения длительностью более 12 недель непрерывного использования.\u003Cbr\u003EОсобые группы пациентов\u003Cbr\u003EДети\u003Cbr\u003EБезопасность и эффективность применения комбинации клиндамицина и бензоила пероксида не были изучены для детей младше 12 лет, поэтому в данной популяции использование комбинации клиндамицина и бензоила пероксида не рекомендуется.\u003Cbr\u003EПациенты пожилого возраста\u003Cbr\u003EСпециальные рекомендации для пожилых пациентов отсутствуют.\u003Cbr\u003EПациенты с почечной недостаточностью\u003Cbr\u003EНеобходимость в коррекции дозы отсутствует.\u003Cbr\u003EПоскольку абсорбция клиндамицина и бензоила пероксида через кожу при местном применении является слабой, маловероятно влияние почечной недостаточности на возникновение клинически значимого системного воздействия.\u003Cbr\u003EПациенты с печеночной недостаточностью\u003Cbr\u003EНеобходимость в коррекции дозы отсутствует.\u003Cbr\u003EПоскольку абсорбция клиндамицина и бензоила пероксида через кожу при местном применении является слабой, маловероятно влияние печеночной недостаточности на возникновение клинически значимого системного воздействия."},{"name":"Побочные действия","value":"Частота встречаемости нежелательных явлений\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EРедко: аллергические реакции, включая гиперчувствительность и анафилактические реакции.\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003EНечасто: парестезия в области нанесения препарата.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr\u003EРедко: колит (включая псевдомембранозный колит), геморрагическая диарея, диарея, боль в животе.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr\u003EОчень часто: чувство жжения, эритема, шелушение, сухость кожи в области нанесения препарата (данные явления в основном слабо выражены).\u003Cbr\u003EЧасто: фотосенсибилизация в области нанесения препарата.\u003Cbr\u003EНечасто: зуд, эритематозная сыпь, дерматит, усугубление акне в области нанесения препарата.\u003Cbr\u003EРедко: крапивница в области нанесения препарата.\u003Cbr\u003EОбщие расстройства и нарушения в области нанесения\u003Cbr\u003EРедко: другие реакции в области нанесения, включая обесцвечивание волос.\u003Cbr\u003EВ исследованиях при местном применении клиндамицина в качестве монотерапии также часто отмечались головная боль и боль в области нанесения препарата."},{"name":"Фармакологическое действие","value":"Клиндамицин является антибиотиком группы линкозамидов, обладающим бактериостатическим действием против грамположительных аэробных микроорганизмов и широкого спектра анаэробных бактерий. Линкозамиды, такие как клиндамицин, связываются с 50S субъединицей рибосом восприимчивых бактерий и, препятствуя транспорту пептидила, предотвращают удлинение пептидных цепей. Действие клиндамицина является в основном бактериостатическим, тем не менее, высокие концентрации могут оказывать медленное бактерицидное воздействие в отношении чувствительных штаммов.\u003Cbr\u003EХотя клиндамицина фосфат является неактивным in vitro, быстрый гидролиз in vivo преобразовывает это соединение в активный клиндамицин.\u003Cbr\u003EБензоила пероксид является высоколипофильным окислителем с бактерицидным и слабым кератолитическим действием. Бензоила пероксид обладает неспецифическим бактерицидным механизмом действия, образуя активные формы кислорода, которые препятствуют появлению резистентныхк клиндамицину микроорганизмов.\u003Cbr\u003EФармакодинамика:\u003Cbr\u003EФармакодинамические эффекты\u003Cbr\u003EКлиндамицин активен in vitro против кутибактерий (Cutibacterium acnes, ранее известных как пропионобактерий Propionibacterium acnes). Существуют данные о возможности развития резистентности C. acnes к клиндамицину. Клиндамицин ингибирует C. acnes in vitro (минимальная ингибирующая концентрация (МИК) - 0,4 мкг/мл).\u003Cbr\u003EПосле нанесения клиндамицин снижает содержание свободных жирных кислот на поверхности кожи приблизительно с 14 % до 2 %, что опосредованно приводит к уменьшению воспаления и комедонообразования. Клиндамицин напрямую уменьшает воспаление путем ингибирования хемотаксиса лейкоцитов.\u003Cbr\u003EЭффективность бензоила пероксида в лечении акне в основном объясняется его бактерицидной активностью, особенно в отношении С. acnes, которая вызвана высвобождением активных или свободных кислородных радикалов, способных окислять бактериальные белки. Бензоила пероксид эффективен при лечении акне благодаря противовоспалительному и некоторому кератолитическому действию.\u003Cbr\u003EРезистентность и перекрёстная резистентность\u003Cbr\u003EЛечение акне такими антибиотиками, как клиндамицин и эритромицин для местного и перорального применения, в форме монотерапии было связано с развитием антимикробной резистентности у C. acnes, а также у сапрофитной флоры (например, Staphylococcus aureus, Streptococcus pyogenes). Длительное использование клиндамицина может вызвать развитие резистентности у этих микроорганизмов.\u003Cbr\u003EБензоила пероксид обладает бактерицидным эффектом, и он не вызывал резистентности у C. acnes. Включение бензоила пероксида в состав комбинированного препарата, содержащего 1 % клиндамицина и 5 % бензоила пероксида, снижало количество резистентных к клиндамицину организмов C. acnes.\u003Cbr\u003EУровень приобретенной резистентности для конкретных организмов может варьировать в зависимости от географического положения и времени.\u003Cbr\u003EЕсли это возможно, следует учитывать местные данные о резистентности, в особенности при лечении серьезных инфекций.\u003Cbr\u003EБыло установлено наличие перекрестной резистентности между клиндамицином и линкомицином."},{"name":"Фармакологическая группа","value":"средство лечения угревой сыпи"},{"name":"Форма выпуска","value":"гель"},{"name":"Способ применения/введения","value":"наружный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["35947170:36763741"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"При температуре от 2 до 8 °С.\u003Cbr\u003EПосле вскрытия хранить при температуре не выше 25 °С."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EНанесение чрезмерного количества препарата может вызывать сильное раздражение. В таких случаях прекращают применение препарата до исчезновения признаков раздражения кожи.\u003Cbr\u003EПри наружном применении бензоила пероксид в основном абсорбируется в количестве, недостаточном для возникновения системных эффектов.\u003Cbr\u003EПри наружном применении чрезмерного количества клиндамицина может произойти его абсорбция в количестве, способном вызвать системные эффекты.\u003Cbr\u003EПри случайном попадании комбинации клиндамицина и бензоила пероксида внутрь могут возникать нежелательные реакции со стороны желудочно-кишечного тракта, схожие с нежелательными реакциями, возникающими при парентеральном применении клиндамицина.\u003Cbr\u003EЛечение\u003Cbr\u003EПрименяют соответствующее симптоматическое лечение для облегчения раздражения, вызванного нанесением чрезмерного количества препарата.\u003Cbr\u003EЛечение при случайном попадании препарата внутрь следует проводить, исходя из клинической ситуации, либо в соответствии с рекомендациями местного Национального токсикологического центра при наличии таковых."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EКонтролируемых исследований с участием беременных женщин, которые используют гель для наружного применения, содержащий комбинацию клиндамицина и бензоила пероксида, проведено не было.\u003Cbr\u003EДанные по использованию препаратов для наружного применения, содержащих одно из действующих веществ (клиндамицин или бензоила пероксид), у беременных женщин ограничены. Доклинические исследования не подтверждают прямого, либо косвенного нежелательного воздействия, которое может быть отнесено к репродуктивной токсичности. Нежелательное воздействие на развитие беременности маловероятно, поскольку уровень системного воздействия клиндамицина и бензоила пероксида является низким.\u003Cbr\u003EТем не менее, комбинацию клиндамицина и бензоила пероксида следует назначать во время беременности только в случае, если ожидаемая польза для матери превышает потенциальный риск для плода.\u003Cbr\u003EЛактация\u003Cbr\u003EНет данных о безопасности наружного применения комбинации клиндамицина и бензоила пероксида в период кормления грудью.\u003Cbr\u003EКлиндамицин и бензоила пероксид обладают слабой чрескожной абсорбцией, однако данные об экскреции в грудное молоко клиндамицина или бензоила пероксида при наружном применении отсутствуют. Клиндамицин экскретируется в грудное молоко при пероральном и парентеральном применении.\u003Cbr\u003EКомбинацию клиндамицина и бензоила пероксида следует использовать в период лактации только в том случае, если ожидаемая польза для матери превышает потенциальный риск для ребенка.\u003Cbr\u003EВо избежание случайного попадания препарата в организм ребенка при его применении в период лактации препарат не следует наносить на кожу груди.\u003Cbr\u003EФертильность:\u003Cbr\u003EНет данных относительно воздействия клиндамицина или бензоила пероксида для наружного применения на репродуктивную функцию."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Негативное влияние препарата на способность к выполнению потенциально опасных видов деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций (управление транспортными средствами, работа с движущимися механизмами, работа диспетчера и оператора) является маловероятным."},{"name":"Особые указания","value":"Следует избегать попадания препарата в рот, глаза, на поверхность губ, другие слизистые оболочки, а также на раздраженные поврежденные области кожи. При случайном попадании геля на указанные участки их следует хорошо промыть водой.\u003Cbr\u003EВо время первых недель лечения у большинства пациентов усиливается шелушение и покраснение кожи. В зависимости от тяжести данных побочных эффектов пациенты могут использовать увлажняющие средства, временно снизить частоту применения препарата, либо временно прекратить применение. Эффективность препарата при применении с частотой реже одного раза в день не изучалась.\u003Cbr\u003EПри возникновении сильного раздражения кожи (например, сильная эритема, сильная сухость кожи и зуд, сильное покалывание/жжение) применение препарата следует прекратить.\u003Cbr\u003EПоскольку бензоила пероксид может вызывать повышенную чувствительность к солнечному свету, следует избегать длительного воздействия солнечных лучей, а также не посещать солярий в период применения препарата. В случае, если пребывания на солнце нельзя избежать, следует использовать солнцезащитные косметические средства для кожи и одежду, защищающую от солнечных лучей.\u003Cbr\u003EПри наличии у пациента солнечных ожогов следует прекратить применение препарата до излечения ожогов.\u003Cbr\u003EПрепарат способен обесцветить волосы и цветную ткань. Следует избегать попадания препарата на волосы, ткань, мебель или ковровое покрытие.\u003Cbr\u003EПсевдомембранозный колит\u003Cbr\u003EСлучаи псевдомембранозного колита были отмечены при системном использовании практически всех антибактериальных средств, включая клиндамицин. Степень их выраженности варьирует по тяжести от слабой до опасной для жизни.\u003Cbr\u003EПсевдомембранозный колит может возникнуть через несколько недель после прекращения терапии.\u003Cbr\u003EНесмотря на то, что возникновение псевдомембранозного колита маловероятно при местном применении комбинации клиндамицина и бензоила пероксида, в случае возникновения длительной или серьезной диареи, либо если пациент страдает коликами в животе, лечение следует немедленно прекратить и обратиться к врачу, поскольку симптомы могут означать присутствие колита, вызванного приемом антибиотика.\u003Cbr\u003EРезистентность к клиндамицину\u003Cbr\u003EБензоила пероксид снижает вероятность появления микроорганизмов, резистентных к клиндамицину. Тем не менее, у пациентов, недавно использовавших клиндамицин или эритромицин для парентерального или местного применения, более вероятно наличие кутибактерий и сапрофитной флоры с ранее приобретенной антимикробной резистентностью.\u003Cbr\u003EПерекрёстная резистентность\u003Cbr\u003EБыло установлено наличие перекрёстной резистентности между клиндамицином и линкомицином.\u003Cbr\u003EРезистентность к клиндамицину часто связана с резистентностью к эритромицину.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EОдновременное применение с другими местными средствами лечения акне следует проводить с осторожностью по причине возможного возникновения кумулятивного раздражения кожи, которое иногда может быть тяжелым, в особенности при применении средств с отшелушивающим, либо абразивным действием.\u003Cbr\u003EЗеркалин Интенсив следует применять с осторожностью при необходимости одновременного приема с миорелаксантами периферического действия.\u003Cbr\u003EЗеркалин Интенсив следует применять с осторожностью у пациентов с атопией в связи с возможным усилением сухости кожи."},{"name":"Взаимодействие","value":"Так как клиндамицин проявляет антагонизм с эритромицином, препарат Зеркалин Интенсив не следует использовать в комбинации с препаратами, содержащими эритромицин.\u003Cbr\u003EУстановлено, что клиндамицин нарушает нейромышечную передачу и, следовательно, может усиливать действие миорелаксантов периферического действия.\u003Cbr\u003EСледует избегать совместного применения комбинации клиндамицина и бензоила пероксида с третиноином, изотретиноином и тазаротеном, посколькубензоила пероксид способен снижать их эффективность и усиливать раздражение кожи. При необходимости комбинированного лечения препараты следует применять в разное время дня (например, один препарат утром и другой препарат вечером).\u003Cbr\u003EИспользование препаратов для местного применения, содержащих бензоила пероксид, одновременно с препаратами для местного применения, содержащими сульфонамид, может вызывать временное изменение цвета кожи и волос в месте нанесения препарата (окраска в желтый или оранжевый цвет)."},{"name":"Регистрационный номер","value":"ЛП-007883"},{"name":"Дата государственной регистрации","value":"18.07.2022"},{"name":"Владелец регистрационного удостоверения","value":"Jadran","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["34324371:35649313","7893318:16003190"]}}},{"name":"Изготовитель","value":"Jadran"},{"name":"Фасовщик","value":"Jadran"},{"name":"Страна бренда","value":"Хорватия"},{"name":"Страна-производитель","value":"Хорватия"},{"name":"Название препарата","value":"Зеркалин","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-kozhi","categoryId":"15756517","navnodeId":"25025070","glfilters":["17796364:17882553"]}}},{"name":"Срок годности","value":"1 г."}]}},"fullSpecsGrouped":{"13125429104424759370":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"кожа"},{"name":"Назначение","value":"угревая болезнь"},{"name":"Показания к применению","value":"Акне (acne vulgaris) легкой и умеренной степени тяжести, особенно с преобладанием воспалительных поражений кожи."},{"name":"Противопоказания","value":"Повышенная чувствительность к клиндамицину, линкомицину, бензоила пероксиду и/или к любому из компонентов препарата;\u003Cbr\u003Eдетский возраст до 12 лет;\u003Cbr\u003Eпериод лактации;\u003Cbr\u003Eболезнь Крона, язвенный колит, псевдомембранозный колит, в том числе в анамнезе."},{"name":"Состав","value":"1 г препарата содержит:\u003Cbr\u003EДействующие вещества:\u003Cbr\u003Eбензоила пероксид водный (в пересчёте на бензоила пероксид безводный)1 - 68,0 мг (50 мг), клиндамицина фосфат (в пересчёте на клиндамицин)1 — 12,3 мг (10 мг);\u003Cbr\u003EВспомогательные вещества:\u003Cbr\u003Eглицерол, карбомер, кремния диоксид коллоидный гидратированный, полоксамер 182, диметикон, динатрия эдетата дигидрат, динатрия лаурилсульфосукцинат, натрия гидроксид, вода очищенная.\u003Cbr\u003E1 - количества действующих веществ могут корректироваться в зависимости от чистоты серии субстанций."},{"name":"Действующее вещество","value":"Бензоила пероксид+Клиндамицин"},{"name":"Способ применения и дозы","value":"Препарат Зеркалин Интенсив предназначен только для наружного применения. Препарат следует наносить тонким слоем с помощью кончиков пальцев на всю пораженную область 1 раз в сутки вечером на чистую и сухую кожу, избегая попадания геля в глаза, на губы, слизистые оболочки.\u003Cbr\u003EПри необходимости после впитывания геля можно использовать увлажняющее средство. При возникновении сухости кожи или шелушения следует сократить частоту применения геля, либо временно приостановить лечение. Эффективность препарата при частоте применения реже 1 раза в день не была изучена.\u003Cbr\u003EБолее частое, чем рекомендуется инструкцией, нанесение геля не повышает эффективность лечения, но может повысить риск возникновения раздражения кожи.\u003Cbr\u003EСредняя длительность курса лечения, необходимая для достижения терапевтического эффекта, составляет от 2 до 5 недель. Продолжительность лечения должна устанавливаться врачом на основании клинического состояния пациента.\u003Cbr\u003EБезопасность и эффективность применения комбинации клиндамицина и бензоила пероксида при лечении акне длительностью более 12 недель не были изучены. Следует тщательно оценить ожидаемую пользу для пациента при назначении лечения длительностью более 12 недель непрерывного использования.\u003Cbr\u003EОсобые группы пациентов\u003Cbr\u003EДети\u003Cbr\u003EБезопасность и эффективность применения комбинации клиндамицина и бензоила пероксида не были изучены для детей младше 12 лет, поэтому в данной популяции использование комбинации клиндамицина и бензоила пероксида не рекомендуется.\u003Cbr\u003EПациенты пожилого возраста\u003Cbr\u003EСпециальные рекомендации для пожилых пациентов отсутствуют.\u003Cbr\u003EПациенты с почечной недостаточностью\u003Cbr\u003EНеобходимость в коррекции дозы отсутствует.\u003Cbr\u003EПоскольку абсорбция клиндамицина и бензоила пероксида через кожу при местном применении является слабой, маловероятно влияние почечной недостаточности на возникновение клинически значимого системного воздействия.\u003Cbr\u003EПациенты с печеночной недостаточностью\u003Cbr\u003EНеобходимость в коррекции дозы отсутствует.\u003Cbr\u003EПоскольку абсорбция клиндамицина и бензоила пероксида через кожу при местном применении является слабой, маловероятно влияние печеночной недостаточности на возникновение клинически значимого системного воздействия."},{"name":"Побочные действия","value":"Частота встречаемости нежелательных явлений\u003Cbr\u003EНарушения со стороны иммунной системы\u003Cbr\u003EРедко: аллергические реакции, включая гиперчувствительность и анафилактические реакции.\u003Cbr\u003EНарушения со стороны нервной системы\u003Cbr\u003EНечасто: парестезия в области нанесения препарата.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта\u003Cbr\u003EРедко: колит (включая псевдомембранозный колит), геморрагическая диарея, диарея, боль в животе.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей\u003Cbr\u003EОчень часто: чувство жжения, эритема, шелушение, сухость кожи в области нанесения препарата (данные явления в основном слабо выражены).\u003Cbr\u003EЧасто: фотосенсибилизация в области нанесения препарата.\u003Cbr\u003EНечасто: зуд, эритематозная сыпь, дерматит, усугубление акне в области нанесения препарата.\u003Cbr\u003EРедко: крапивница в области нанесения препарата.\u003Cbr\u003EОбщие расстройства и нарушения в области нанесения\u003Cbr\u003EРедко: другие реакции в области нанесения, включая обесцвечивание волос.\u003Cbr\u003EВ исследованиях при местном применении клиндамицина в качестве монотерапии также часто отмечались головная боль и боль в области нанесения препарата."},{"name":"Фармакологическое действие","value":"Клиндамицин является антибиотиком группы линкозамидов, обладающим бактериостатическим действием против грамположительных аэробных микроорганизмов и широкого спектра анаэробных бактерий. Линкозамиды, такие как клиндамицин, связываются с 50S субъединицей рибосом восприимчивых бактерий и, препятствуя транспорту пептидила, предотвращают удлинение пептидных цепей. Действие клиндамицина является в основном бактериостатическим, тем не менее, высокие концентрации могут оказывать медленное бактерицидное воздействие в отношении чувствительных штаммов.\u003Cbr\u003EХотя клиндамицина фосфат является неактивным in vitro, быстрый гидролиз in vivo преобразовывает это соединение в активный клиндамицин.\u003Cbr\u003EБензоила пероксид является высоколипофильным окислителем с бактерицидным и слабым кератолитическим действием. Бензоила пероксид обладает неспецифическим бактерицидным механизмом действия, образуя активные формы кислорода, которые препятствуют появлению резистентныхк клиндамицину микроорганизмов.\u003Cbr\u003EФармакодинамика:\u003Cbr\u003EФармакодинамические эффекты\u003Cbr\u003EКлиндамицин активен in vitro против кутибактерий (Cutibacterium acnes, ранее известных как пропионобактерий Propionibacterium acnes). Существуют данные о возможности развития резистентности C. acnes к клиндамицину. Клиндамицин ингибирует C. acnes in vitro (минимальная ингибирующая концентрация (МИК) - 0,4 мкг/мл).\u003Cbr\u003EПосле нанесения клиндамицин снижает содержание свободных жирных кислот на поверхности кожи приблизительно с 14 % до 2 %, что опосредованно приводит к уменьшению воспаления и комедонообразования. Клиндамицин напрямую уменьшает воспаление путем ингибирования хемотаксиса лейкоцитов.\u003Cbr\u003EЭффективность бензоила пероксида в лечении акне в основном объясняется его бактерицидной активностью, особенно в отношении С. acnes, которая вызвана высвобождением активных или свободных кислородных радикалов, способных окислять бактериальные белки. Бензоила пероксид эффективен при лечении акне благодаря противовоспалительному и некоторому кератолитическому действию.\u003Cbr\u003EРезистентность и перекрёстная резистентность\u003Cbr\u003EЛечение акне такими антибиотиками, как клиндамицин и эритромицин для местного и перорального применения, в форме монотерапии было связано с развитием антимикробной резистентности у C. acnes, а также у сапрофитной флоры (например, Staphylococcus aureus, Streptococcus pyogenes). Длительное использование клиндамицина может вызвать развитие резистентности у этих микроорганизмов.\u003Cbr\u003EБензоила пероксид обладает бактерицидным эффектом, и он не вызывал резистентности у C. acnes. Включение бензоила пероксида в состав комбинированного препарата, содержащего 1 % клиндамицина и 5 % бензоила пероксида, снижало количество резистентных к клиндамицину организмов C. acnes.\u003Cbr\u003EУровень приобретенной резистентности для конкретных организмов может варьировать в зависимости от географического положения и времени.\u003Cbr\u003EЕсли это возможно, следует учитывать местные данные о резистентности, в особенности при лечении серьезных инфекций.\u003Cbr\u003EБыло установлено наличие перекрестной резистентности между клиндамицином и линкомицином."},{"name":"Фармакологическая группа","value":"средство лечения угревой сыпи"},{"name":"Форма выпуска","value":"гель"},{"name":"Способ применения/введения","value":"наружный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре от 2 до 8 °С.\u003Cbr\u003EПосле вскрытия хранить при температуре не выше 25 °С."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EНанесение чрезмерного количества препарата может вызывать сильное раздражение. В таких случаях прекращают применение препарата до исчезновения признаков раздражения кожи.\u003Cbr\u003EПри наружном применении бензоила пероксид в основном абсорбируется в количестве, недостаточном для возникновения системных эффектов.\u003Cbr\u003EПри наружном применении чрезмерного количества клиндамицина может произойти его абсорбция в количестве, способном вызвать системные эффекты.\u003Cbr\u003EПри случайном попадании комбинации клиндамицина и бензоила пероксида внутрь могут возникать нежелательные реакции со стороны желудочно-кишечного тракта, схожие с нежелательными реакциями, возникающими при парентеральном применении клиндамицина.\u003Cbr\u003EЛечение\u003Cbr\u003EПрименяют соответствующее симптоматическое лечение для облегчения раздражения, вызванного нанесением чрезмерного количества препарата.\u003Cbr\u003EЛечение при случайном попадании препарата внутрь следует проводить, исходя из клинической ситуации, либо в соответствии с рекомендациями местного Национального токсикологического центра при наличии таковых."},{"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EКонтролируемых исследований с участием беременных женщин, которые используют гель для наружного применения, содержащий комбинацию клиндамицина и бензоила пероксида, проведено не было.\u003Cbr\u003EДанные по использованию препаратов для наружного применения, содержащих одно из действующих веществ (клиндамицин или бензоила пероксид), у беременных женщин ограничены. Доклинические исследования не подтверждают прямого, либо косвенного нежелательного воздействия, которое может быть отнесено к репродуктивной токсичности. Нежелательное воздействие на развитие беременности маловероятно, поскольку уровень системного воздействия клиндамицина и бензоила пероксида является низким.\u003Cbr\u003EТем не менее, комбинацию клиндамицина и бензоила пероксида следует назначать во время беременности только в случае, если ожидаемая польза для матери превышает потенциальный риск для плода.\u003Cbr\u003EЛактация\u003Cbr\u003EНет данных о безопасности наружного применения комбинации клиндамицина и бензоила пероксида в период кормления грудью.\u003Cbr\u003EКлиндамицин и бензоила пероксид обладают слабой чрескожной абсорбцией, однако данные об экскреции в грудное молоко клиндамицина или бензоила пероксида при наружном применении отсутствуют. Клиндамицин экскретируется в грудное молоко при пероральном и парентеральном применении.\u003Cbr\u003EКомбинацию клиндамицина и бензоила пероксида следует использовать в период лактации только в том случае, если ожидаемая польза для матери превышает потенциальный риск для ребенка.\u003Cbr\u003EВо избежание случайного попадания препарата в организм ребенка при его применении в период лактации препарат не следует наносить на кожу груди.\u003Cbr\u003EФертильность:\u003Cbr\u003EНет данных относительно воздействия клиндамицина или бензоила пероксида для наружного применения на репродуктивную функцию."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Негативное влияние препарата на способность к выполнению потенциально опасных видов деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций (управление транспортными средствами, работа с движущимися механизмами, работа диспетчера и оператора) является маловероятным."},{"name":"Особые указания","value":"Следует избегать попадания препарата в рот, глаза, на поверхность губ, другие слизистые оболочки, а также на раздраженные поврежденные области кожи. При случайном попадании геля на указанные участки их следует хорошо промыть водой.\u003Cbr\u003EВо время первых недель лечения у большинства пациентов усиливается шелушение и покраснение кожи. В зависимости от тяжести данных побочных эффектов пациенты могут использовать увлажняющие средства, временно снизить частоту применения препарата, либо временно прекратить применение. Эффективность препарата при применении с частотой реже одного раза в день не изучалась.\u003Cbr\u003EПри возникновении сильного раздражения кожи (например, сильная эритема, сильная сухость кожи и зуд, сильное покалывание/жжение) применение препарата следует прекратить.\u003Cbr\u003EПоскольку бензоила пероксид может вызывать повышенную чувствительность к солнечному свету, следует избегать длительного воздействия солнечных лучей, а также не посещать солярий в период применения препарата. В случае, если пребывания на солнце нельзя избежать, следует использовать солнцезащитные косметические средства для кожи и одежду, защищающую от солнечных лучей.\u003Cbr\u003EПри наличии у пациента солнечных ожогов следует прекратить применение препарата до излечения ожогов.\u003Cbr\u003EПрепарат способен обесцветить волосы и цветную ткань. Следует избегать попадания препарата на волосы, ткань, мебель или ковровое покрытие.\u003Cbr\u003EПсевдомембранозный колит\u003Cbr\u003EСлучаи псевдомембранозного колита были отмечены при системном использовании практически всех антибактериальных средств, включая клиндамицин. Степень их выраженности варьирует по тяжести от слабой до опасной для жизни.\u003Cbr\u003EПсевдомембранозный колит может возникнуть через несколько недель после прекращения терапии.\u003Cbr\u003EНесмотря на то, что возникновение псевдомембранозного колита маловероятно при местном применении комбинации клиндамицина и бензоила пероксида, в случае возникновения длительной или серьезной диареи, либо если пациент страдает коликами в животе, лечение следует немедленно прекратить и обратиться к врачу, поскольку симптомы могут означать присутствие колита, вызванного приемом антибиотика.\u003Cbr\u003EРезистентность к клиндамицину\u003Cbr\u003EБензоила пероксид снижает вероятность появления микроорганизмов, резистентных к клиндамицину. Тем не менее, у пациентов, недавно использовавших клиндамицин или эритромицин для парентерального или местного применения, более вероятно наличие кутибактерий и сапрофитной флоры с ранее приобретенной антимикробной резистентностью.\u003Cbr\u003EПерекрёстная резистентность\u003Cbr\u003EБыло установлено наличие перекрёстной резистентности между клиндамицином и линкомицином.\u003Cbr\u003EРезистентность к клиндамицину часто связана с резистентностью к эритромицину.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EОдновременное применение с другими местными средствами лечения акне следует проводить с осторожностью по причине возможного возникновения кумулятивного раздражения кожи, которое иногда может быть тяжелым, в особенности при применении средств с отшелушивающим, либо абразивным действием.\u003Cbr\u003EЗеркалин Интенсив следует применять с осторожностью при необходимости одновременного приема с миорелаксантами периферического действия.\u003Cbr\u003EЗеркалин Интенсив следует применять с осторожностью у пациентов с атопией в связи с возможным усилением сухости кожи."},{"name":"Взаимодействие","value":"Так как клиндамицин проявляет антагонизм с эритромицином, препарат Зеркалин Интенсив не следует использовать в комбинации с препаратами, содержащими эритромицин.\u003Cbr\u003EУстановлено, что клиндамицин нарушает нейромышечную передачу и, следовательно, может усиливать действие миорелаксантов периферического действия.\u003Cbr\u003EСледует избегать совместного применения комбинации клиндамицина и бензоила пероксида с третиноином, изотретиноином и тазаротеном, посколькубензоила пероксид способен снижать их эффективность и усиливать раздражение кожи. При необходимости комбинированного лечения препараты следует применять в разное время дня (например, один препарат утром и другой препарат вечером).\u003Cbr\u003EИспользование препаратов для местного применения, содержащих бензоила пероксид, одновременно с препаратами для местного применения, содержащими сульфонамид, может вызывать временное изменение цвета кожи и волос в месте нанесения препарата (окраска в желтый или оранжевый цвет)."},{"name":"Регистрационный номер","value":"ЛП-007883"},{"name":"Дата государственной регистрации","value":"18.07.2022"},{"name":"Владелец регистрационного удостоверения","value":"Jadran"},{"name":"Изготовитель","value":"Jadran"},{"name":"Фасовщик","value":"Jadran"},{"name":"Страна бренда","value":"Хорватия"},{"name":"Страна-производитель","value":"Хорватия"},{"name":"Название препарата","value":"Зеркалин"},{"name":"Срок годности","value":"1 г."}]}],"transitionId":"tr_15522221543337611597"}}}}
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Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    Цена с картой Яндекс Пэй 571 ₽ вместо 583
    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  • Клензит-C гель д/нар. прим., 30 г
    –2 %
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    Клензит-C гель д/нар. прим., 30 г

    Рейтинг товара: 4.8 из 5
    на основе 104 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 403 ₽ вместо 1 431
    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  • Зеркалин р-р д/нар. прим. фл., 10 мг/мл, 30 мл
    –21 %
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    Зеркалин р-р д/нар. прим. фл., 10 мг/мл, 30 мл

    Рейтинг товара: 4.9 из 5
    на основе 16 оценок
    Цена 579 ₽ вместо 733
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  • Азелик гель д/нар. прим., 15%, 30 мл, 30 г
    –1 %
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    Азелик гель д/нар. прим., 15%, 30 мл, 30 г

    Рейтинг товара: 4.8 из 5
    на основе 83 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 992 ₽ вместо 1 002
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  • Постакнетин гель, 10 мл, 10 г
    –1 %
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    Постакнетин гель, 10 мл, 10 г

    Рейтинг товара: 4.5 из 5
    на основе 21 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 620 ₽ вместо 626
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  • Базирон АС гель д/нар. прим., 2,5 %, 40 мл, 40 г
    –1 %
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    Базирон АС гель д/нар. прим., 2,5 %, 40 мл, 40 г

    Рейтинг товара: 4.9 из 5
    на основе 71 оценка
    С картой  Пэй
    Цена с картой Яндекс Пэй 1 312 ₽ вместо 1 325
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  • Клензит гель д/нар. прим., 15 г
    –1 %
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    Клензит гель д/нар. прим., 15 г

    Рейтинг товара: 5 из 5
    на основе 9 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 751 ₽ вместо 759
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  • Скиноклир гель д/нар. прим. туба, 15%, 30 мл, 30 г
    ВАМ–16 %
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    Скиноклир гель д/нар. прим. туба, 15%, 30 мл, 30 г

    Рейтинг товара: 4.8 из 5
    на основе 72 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 648 ₽ вместо 655
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  • Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.
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    Эффезел гель д/нар. прим., 1 мг/г+25 мг/г, 30 мл, 30 г, 1 шт.

    Рейтинг товара: 4.9 из 5
    на основе 41 оценка
    Цена 2 078 ₽
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  • Скиноклир крем д/нар.прим. туба, 20%, 30 г
    ВАМ–16 %
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    Скиноклир крем д/нар.прим. туба, 20%, 30 г

    Рейтинг товара: 4.8 из 5
    на основе 53 оценки
    С картой  Пэй
    Цена с картой Яндекс Пэй 675 ₽ вместо 682
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  • Клиндовит Комбо гель д/нар.прим, 50 мг+10 мг/г, 15 г
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    Клиндовит Комбо гель д/нар.прим, 50 мг+10 мг/г, 15 г

    Рейтинг товара: 4.8 из 5
    на основе 4 оценки
    Цена 639 ₽
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  • Розамет крем, 1%, 25 мл, 25 г
    ВАМ–7 %
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    Розамет крем, 1%, 25 мл, 25 г

    Рейтинг товара: 4.4 из 5
    на основе 9 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 340 ₽ вместо 343
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Инструкция

Показания к применению

Акне (acne vulgaris) легкой и умеренной степени тяжести, особенно с преобладанием воспалительных поражений кожи.

Противопоказания

Повышенная чувствительность к клиндамицину, линкомицину, бензоила пероксиду и/или к любому из компонентов препарата;
детский возраст до 12 лет;
период лактации;
болезнь Крона, язвенный колит, псевдомембранозный колит, в том числе в анамнезе.

Способ применения и дозы

Препарат Зеркалин Интенсив предназначен только для наружного применения. Препарат следует наносить тонким слоем с помощью кончиков пальцев на всю пораженную область 1 раз в сутки вечером на чистую и сухую кожу, избегая попадания геля в глаза, на губы, слизистые оболочки.
При необходимости после впитывания геля можно использовать увлажняющее средство. При возникновении сухости кожи или шелушения следует сократить частоту применения геля, либо временно приостановить лечение. Эффективность препарата при частоте применения реже 1 раза в день не была изучена.
Более частое, чем рекомендуется инструкцией, нанесение геля не повышает эффективность лечения, но может повысить риск возникновения раздражения кожи.
Средняя длительность курса лечения, необходимая для достижения терапевтического эффекта, составляет от 2 до 5 недель. Продолжительность лечения должна устанавливаться врачом на основании клинического состояния пациента.
Безопасность и эффективность применения комбинации клиндамицина и бензоила пероксида при лечении акне длительностью более 12 недель не были изучены. Следует тщательно оценить ожидаемую пользу для пациента при назначении лечения длительностью более 12 недель непрерывного использования.
Особые группы пациентов
Дети
Безопасность и эффективность применения комбинации клиндамицина и бензоила пероксида не были изучены для детей младше 12 лет, поэтому в данной популяции использование комбинации клиндамицина и бензоила пероксида не рекомендуется.
Пациенты пожилого возраста
Специальные рекомендации для пожилых пациентов отсутствуют.
Пациенты с почечной недостаточностью
Необходимость в коррекции дозы отсутствует.
Поскольку абсорбция клиндамицина и бензоила пероксида через кожу при местном применении является слабой, маловероятно влияние почечной недостаточности на возникновение клинически значимого системного воздействия.
Пациенты с печеночной недостаточностью
Необходимость в коррекции дозы отсутствует.
Поскольку абсорбция клиндамицина и бензоила пероксида через кожу при местном применении является слабой, маловероятно влияние печеночной недостаточности на возникновение клинически значимого системного воздействия.
Полная инструкция
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Зеркалин Интенсив гель д/нар. прим.
Зеркалин Интенсив гель д/нар. прим., 50 мг+10 мг/г, 30 мл, 25 г
4.9
(25)
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Задать вопрос
Инструкция

963 ₽

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4.9
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У продавца:25 оценок·4 отзыва
У всех продавцов:87 оценок·29 отзывов
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user avatar
5 месяцев назад • Имя скрыто • Куплен на Маркете
Достоинства: Не вызвал раздражения, пока что вроде есть результат
Комментарий: Назначил косметолог в качестве самого сильного средства из всех, что были ранее
user avatar
4 месяца назад • Александр Морев • Куплен на Маркете
Достоинства: Очень хорошая средство
Недостатки: Быстро кончается
Комментарий: Пользуюсь год, проблемы с прыщами, только эта мазь помогает
user avatar
Месяц назад • Наталия Беланова • Куплен на Маркете
Достоинства: Лучшее средство, назначено дерматологом
Комментарий: Быстрая доставка, конкурентная цена
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    Жидкий пластырь Fixplast c пантенолом, 60 мл

    Цена 355 ₽ вместо 399
  • Зеркалин р-р д/нар. прим. фл., 10 мг/мл, 30 мл
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    Зеркалин р-р д/нар. прим. фл., 10 мг/мл, 30 мл

    Цена 579 ₽ вместо 733
  • Клиндовит гель д/нар. прим., 1%, 30 г
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    Клиндовит гель д/нар. прим., 1%, 30 г

    Цена 501 ₽ вместо 506
  • Азелик гель д/нар. прим., 15%, 30 мл, 30 г
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    Азелик гель д/нар. прим., 15%, 30 мл, 30 г

    Цена 992 ₽ вместо 1 002
  • Постакнетин гель, 10 мл, 10 г
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    Постакнетин гель, 10 мл, 10 г

    Цена 620 ₽ вместо 626
  • Базирон АС гель д/нар. прим., 2,5 %, 40 мл, 40 г
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    Базирон АС гель д/нар. прим., 2,5 %, 40 мл, 40 г

    Цена 1 312 ₽ вместо 1 325
  • Минолексин капс., 50 мг, 20 шт.
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    Минолексин капс., 50 мг, 20 шт.

    Цена 776 ₽
  • Vitamin D3, 10000 МЕ, 120 шт.
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    Vitamin D3, 10000 МЕ, 120 шт.

    Цена 1 216 ₽ вместо 1 850
  • Реклама
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  • ЛимфоТранзит концентрат напитка фл., 100 мл
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • Клензит-C гель д/нар. прим., 15 г
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    Клензит-C гель д/нар. прим., 15 г

    Цена 996 ₽ вместо 1 006
  • Салфетка с нашатырем для стимуляции дыхания 3х6, 20 шт
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    Салфетка с нашатырем для стимуляции дыхания 3х6, 20 шт

    Цена 197 ₽ вместо 250
  • Клензит гель д/нар. прим., 15 г
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    Клензит гель д/нар. прим., 15 г

    Цена 751 ₽ вместо 759
  • Крем для лица и тела после загара MIXIT "BACK TO SUN" защитный, увлажняющий, с пантенолом и алоэ вера, 150 мл
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    Крем для лица и тела после загара MIXIT "BACK TO SUN" защитный, увлажняющий, с пантенолом и алоэ вера, 150 мл

    Цена 686 ₽ вместо 1 400
  • Argitos Коллоидное серебро спрей д/мест. прим. фл., 30 мл, 40 г, нейтральный
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    Argitos Коллоидное серебро спрей д/мест. прим. фл., 30 мл, 40 г, нейтральный

    Цена 365 ₽ вместо 395
  • Фенибут таб., 250 мг, 20 шт.
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    Фенибут таб., 250 мг, 20 шт.

    Цена 131 ₽
  • Салфетка спиртовая (этиловый спирт) 60*100 мм 100 шт.
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    Салфетка спиртовая (этиловый спирт) 60*100 мм 100 шт.

    Цена 208 ₽ вместо 288
  • Кето плюс шампунь, 60 мл, 1 шт.
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    Кето плюс шампунь, 60 мл, 1 шт.

    Цена 999 ₽ вместо 1 009
  • Кетоконазол шампунь лекарственный, 2%, 75 г, 75 мл
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    Кетоконазол шампунь лекарственный, 2%, 75 г, 75 мл

    Цена 296 ₽ вместо 299
  • Бинт когезивный (самофиксирующийся) "Вариант", 4м х 6см , белый, 2 шт в наборе
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    Бинт когезивный (самофиксирующийся) "Вариант", 4м х 6см , белый, 2 шт в наборе

    Цена 346 ₽ вместо 389
  • "Асептика" - Салфетки спиртовые антисептические, 6х10см, 100шт
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    "Асептика" - Салфетки спиртовые антисептические, 6х10см, 100шт

    Цена 210 ₽ вместо 250
  • Реклама
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    Марля медицинская повышенной плотности, отрез 3 метра

    Цена 157 ₽ вместо 199
  • Скиноклир гель д/нар. прим. туба, 15%, 30 мл, 30 г
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    Цена 648 ₽ вместо 771
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