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Описание

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Золмитриптан-СЗ таб. п/о плен., 2.5 мг, 10 шт.

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4.8
(13)
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Коротко о товаре

Артикул Маркета
3123240433
Тип препарата
Назначение
Действующее вещество
Форма выпуска
таблетки, покрытые пленочной оболочкой
Инструкция
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Неконтролируемая артериальная гипертензия.\u003Cbr\u003EИшемическая болезнь сердца.\u003Cbr\u003EКоронарный вазоспазм / стенокардия Принцметала.\u003Cbr\u003EЗаболевания периферических артерий.\u003Cbr\u003EНарушение мозгового кровообращения (в том числе, инсульт или транзиторная ишемическая атака) в анамнезе.\u003Cbr\u003EСиндром Вольфа-Паркинсона-Уайта или аритмии, ассоциированные с другими дополнительными путями проведения импульса.\u003Cbr\u003EТяжелая почечная недостаточность (клиренс креатинина менее 15 мл/мин).\u003Cbr\u003EСовместное применение с другими агонистами серотониновых 5HТ1b/1d- рецепторов (например, суматриптаном, наратриптаном), эрготамином или его производными (в том числе, метизергидом), а также в течение 24 часов после их отмены.\u003Cbr\u003EСовместное применение с ингибиторами МАО-А и в течение 14 дней после их отмены.\u003Cbr\u003EНепереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция."},{"name":"Состав","value":"1 таблетка содержит: действующее вещество: золмитриптан - 2,5 мг; вспомогательные вещества: лактоза безводная (сахар молочный безводный) - 98,3 мг, целлюлоза микрокристаллическая (тип 102) - 15,0 мг, карбоксиметилкрахмал натрия - 3,0 мг, магния стеарат -1,2 мг; состав оболочки: гипромеллоза - 2,15 мг, полисорбат-80 (твин-80) - 0,60 мг, тальк - 0,60 мг, титана диоксид Е 171 - 0,45 мг, краситель железа оксид желтый Е 172 - 0,20 мг."},{"name":"Действующее вещество","value":"Золмитриптан","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["27144131:28708645"]}}},{"name":"Способ применения и дозы","value":"Таблетки следует принимать внутрь целиком, запивая водой.\u003Cbr\u003EРекомендуемая доза препарата для снятия приступа мигрени - 2,5 мг (1 таблетка). Рекомендуется принимать препарат как можно раньше с момента начала головной боли, однако препарат эффективен и при приеме в более поздние сроки после начала приступа.\u003Cbr\u003EЕсли симптомы мигрени возникают вновь в течение 24 часов, можно принять повторную дозу препарата Золмитриптан-СЗ. Не следует принимать повторную дозу ранее, чем через 2 часа после приема первой дозы. Если после приема первой дозы не отмечено клинического эффекта, маловероятна польза от повторного приема препарата во время того же приступа.\u003Cbr\u003EЕсли у пациента не был достигнут терапевтический эффект после приема дозы 2,5 мг, для снятия последующих приступов мигрени можно применять препарат Золмитриптан-СЗ в дозе 5 мг (2 таблетки).\u003Cbr\u003EНе следует принимать более 2 доз препарата Золмитриптан-СЗ в сутки. Суммарная доза золмитриптана, принятая в течение суток, не должна превышать 10 мг (4 таблетки).\u003Cbr\u003EПрепарат Золмитриптан-СЗ не показан для профилактики мигрени.\u003Cbr\u003EПрименение у особых групп пациентов\u003Cbr\u003EДетский и подростковый возраст\u003Cbr\u003EЭффективность и безопасность применения золмитриптана у детей до 12 лет не изучалась. Эффективность применения золмитриптана в плацебоконтролируемом клиническом исследовании у пациентов в возрасте от 12 до 17 лет не установлена. Применение препарата Золмитриптан-СЗ у детей и подростков не рекомендуется.\u003Cbr\u003EПожилой возраст\u003Cbr\u003EЭффективность и безопасность золмитриптана у пациентов старше 65 лет не установлена. Поэтому применение препарата Золмитриптан-СЗ у пациентов пожилого возраста не рекомендуется.\u003Cbr\u003EНарушение функции печени\u003Cbr\u003EКоррекция дозы при легком и умеренном нарушении функции печени не требуется. Для пациентов с тяжелым нарушением функции печени суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг.\u003Cbr\u003EПочечная недостаточность\u003Cbr\u003EКоррекция дозы не требуется, если клиренс креатинина выше 15 мл/мин. Препарат противопоказан при почечной недостаточности тяжелой степени тяжести (клиренс креатинина менее 15 мл/мин).\u003Cbr\u003EВзаимодействие с другими лекарственными средствами, требующее коррекции дозы\u003Cbr\u003EДля пациентов, принимающих циметидин или селективные ингибиторы изофермента CYP1A2 (например, флувоксамин, ципрофлоксацин и другие хинолоны) суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг."},{"name":"Побочные действия","value":"Нежелательные реакции при применении золмитриптана, как правило, возникают в течение 4 часов после приема препарата, носят транзиторный характер и разрешаются спонтанно без лечения. Частота нежелательных реакций не увеличивается при приеме повторных доз.\u003Cbr\u003EЧастота развития нежелательных реакций представлена согласно классификации ВОЗ: очень часто (≥1/10 случаев); часто (≥1/100 и \u003C1/10 случаев); нечасто (≥1/1000 и \u003C1/100 случаев); редко (≥1/10000 и \u003C1/1000 случаев); очень редко (\u003C1/10000 случаев).\u003Cbr\u003EСо стороны центральной нервной системы: часто - нарушения чувствительности, головокружение, гиперестезия, парестезии, сонливость, ощущение \"тепла\" или \"холода\", вертиго.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: часто - ощущение сердцебиения; нечасто - тахикардия, незначительное повышение артериального давления, транзиторное повышение артериального давления; очень редко - инфаркт миокарда, стенокардия, коронарный ангиоспазм.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: часто - боль в животе; тошнота, рвота, сухость во рту, диспепсия, дисфагия; очень редко - ишемия или инфаркт (например, ишемия или инфаркт кишки, инфаркт селезенки), симптомами которых могут быть диарея с примесью крови и боль в животе.\u003Cbr\u003EСо стороны костно-мышечной системы: часто - мышечная слабость, миалгия.\u003Cbr\u003EСо стороны мочевыделительной системы: нечасто - полиурия, частое мочеиспускание; очень редко - императивные позывы к мочеиспусканию.\u003Cbr\u003EСо стороны иммунной системы: редко - реакции гиперчувствительности, в том числе, крапивница, ангионевротический отек и анафилактические реакции.\u003Cbr\u003EОбщие расстройства: часто - астения, инертность, чувство стеснения дыхания, боль или чувство стеснения в глотке, области шеи, грудной клетке или конечностях, повышенное потоотделение.\u003Cbr\u003EНекоторые из перечисленных симптомов могут быть симптомами мигрени.\u003Cbr\u003EЕсли любые из указанных в инструкции нежелательные реакции усугубляются, или Вы заметили другие нежелательных реакций не указанные в инструкции, сообщите об этом врачу."},{"name":"Фармакологическое действие","value":"Золмитриптан является селективным агонистом 5НТ1B/1D-рецепторов, стимуляция которых приводит к вазоконстрикции. Обладает высоким сродством к рекомбинантным 5НТ1B/1D-рецепторам человека и умеренным сродством к 5НТ1A-рецепторам. Золмитриптан не обладает сродством и не проявляет существенной фармакологической активности по отношению к 5HT2, 5НТ3, 5НТ4, адренергическим, гистаминовым, мускариновым и дофаминергическим рецепторам.\u003Cbr\u003EВведение золмитриптана лабораторным животным приводило к вазоконстрикции в бассейне сонной артерии. Кроме того, результаты исследований на лабораторных животных свидетельствуют о том, что золмитриптан блокирует центральную и периферическую активность тройничного нерва за счет ингибирования высвобождения пептида, связанного с геном кальцитонина, вазоактивного интестинального пептида и субстанции Р.\u003Cbr\u003EВ клинических исследованиях эффект золмитриптана в отношении головной боли и других симптомов мигрени (таких как тошнота, фотофобия, фонофобия) отмечался через 1 час и нарастал в период от 2 до 4 часов после приема препарата.\u003Cbr\u003EЗолмитриптан одинаково эффективен в отношении мигрени с аурой, мигрени без ауры и мигрени, ассоциированной с менструацией. Прием золмитриптана во время ауры не предотвращал мигренозной головой боли, поэтому препарат следует принимать после начала болевого приступа."},{"name":"Фармакологическая группа","value":"противомигренозное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EПри однократном приеме внутрь золмитриптана в дозе 50 мг здоровыми добровольцами обычно отмечался седативный эффект. Период полувыведения золмитриптана составляет 2,5 - 3 часа, поэтому при передозировке наблюдение за пациентом должно продолжаться, как минимум в течение 15 часов или пока имеются симптомы передозировки.\u003Cbr\u003EЛечение\u003Cbr\u003EДля золмитриптана нет специфического антидота. В случае выраженной интоксикации рекомендуются мероприятия интенсивной терапии, включая восстановление и поддержание проходимости дыхательных путей, обеспечение адекватной оксигенации и вентиляции легких, а также наблюдение и поддержку функции сердечно-сосудистой системы.\u003Cbr\u003EЭффект гемодиализа и перитонеального диализа в отношении концентрации золмитриптана в сыворотке не установлен."},{"name":"Применение при беременности и кормлении грудью","value":"Безопасность применения золмитриптана во время беременности не изучалась. Результаты исследований на животных не выявили прямых тератогенных эффектов. Однако, некоторые данные исследований эмбриотоксичности свидетельствуют о возможном снижении жизнеспособности эмбрионов. Применение препарата противопоказано в период беременности.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EЗолмитриптан проникает в молоко лактирующих животных. Неизвестно, проникает ли золмитриптан в грудное молоко женщин в период грудного вскармливания. Поэтому необходимо с осторожностью подходить к вопросу назначения препарата женщинам в период грудного вскармливания. Прекращение грудного вскармливания на 24 часа позволяет минимизировать воздействие золмитриптана на грудного ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не наблюдалось значительного ухудшения в выполнении психомоторных тестов при приеме золмитриптана в дозе до 20 мг. Пациентам, деятельность которых требует высокой скорости психомоторных реакций (например, управление транспортным средством или механизмами), рекомендуется соблюдать осторожность из-за возможного развития сонливости и других симптомов мигрени."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EТяжелое нарушение функции печени.\u003Cbr\u003EПрепарат Золмитриптан-СЗ может применяться только в случаях четко диагностированной мигрени. До назначения золмитриптана, как и других средств для купирования мигрени, необходимо исключить другие возможные серьезные неврологические заболевания у пациентов с ранее не диагностированной мигренью, а также у пациентов с установленным диагнозом мигрени при наличии атипичных симптомов. Золмитриптан не показан для лечения гемиплегической, базилярной и офтальмоплегической мигрени. У пациентов, принимающих агонисты серотониновых 5НТш/т- рецепторов, отмечались нарушения мозгового кровообращения, в том числе, инсульты. Пациенты с мигренью могут быть подвержены риску развития определенных нарушений мозгового кровообращения.\u003Cbr\u003EНе следует применять золмитриптан у пациентов с синдромом Вольфа-Паркинсона-Уайта или аритмиями, ассоциированными с другими дополнительными путями проведения импульса.\u003Cbr\u003EОчень редко при применении данного класса препаратов (агонисты серотониновых 5НТ1b/1d -рецепторов) отмечались коронарный ангиоспазм, стенокардия и инфаркт миокарда.\u003Cbr\u003EПеред назначением золмитриптана пациентам с факторами риска развития ишемической болезни сердца (ИБС) (например, курение, артериальная гипертензия, гиперлипидемия, сахарный диабет, отягощенный семейный анамнез в отношении ИБС) рекомендуется провести обследование сердечно¬сосудистой системы, необходимо контролировать артериальное давление и электрокардиограмму. Особое внимание следует уделять женщинам в постменопаузальном периоде и мужчинам старше 40 лет при наличии указанных факторов риска. Тем не менее, не у всех пациентов при обследовании удается выявить сердечно-сосудистые заболевания, и в очень редких случаях серьезные сердечно-сосудистые осложнения могут развиться у пациентов, не имевших указаний на сердечно-сосудистые заболевания в анамнезе.\u003Cbr\u003EКак и в случае применения других агонистов серотониновых 5HT1b/1d- рецепторов, при применении золмитриптана сообщалось об ощущениях тяжести, давления или стеснения в области сердца. При возникновении болей в области грудной клетки или симптомов ишемической болезни сердца следует прекратить прием золмитриптана до проведения соответствующего медицинского обследования.\u003Cbr\u003EКак и в случае других агонистов серотониновых 5НТ1b/1d -рецепторов, транзиторное повышение артериального давления отмечалось у пациентов независимо от наличия артериальной гипертензии в анамнезе (очень редко такое повышение артериального давления было клинически выраженным). Не следует превышать рекомендованные дозы золмитриптана.\u003Cbr\u003EПобочные эффекты могут быть более частыми при одновременном приеме триптанов и растительных препаратов, содержащих зверобой продырявленный (Hypericum perforatum).\u003Cbr\u003EОтмечалось развитие серотонинового синдрома при сочетанном применении триптанов и СИОЗС или СИОЗСиН. Серотониновый синдром может включать следующие признаки и симптомы: изменения психического состояния, вегетативные и нервно-мышечные симптомы. Рекомендуется тщательное наблюдение за пациентами при сопутствующем назначении препарата Золмитриптан-СЗ и СИОЗС или СИОЗСиН, особенно в период начала терапии, увеличения дозы или добавления к терапии другого препарата, влияющего на обмен серотонина (см. раздел \"Взаимодействие с другими лекарственными средствами\").\u003Cbr\u003EЧрезмерное применение противомигренозных препаратов может приводить к увеличению частоты возникновения головной боли, что потенциально требует отмены лечения. Если у пациента отмечаются частые или ежедневные головные боли, несмотря на регулярный прием препаратов для лечения этого состояния, следует помнить о возможности развития головной боли при избыточном употреблении лекарственных препаратов для терапии головной боли."},{"name":"Взаимодействие","value":"В исследованиях по изучению взаимодействия золмитриптана с кофеином, эрготамином, дигидроэрготамином, парацетамолом, метоклопрамидом, пизотифеном, флуоксетином, рифампицином и пропранололом клинически значимых изменений фармакокинетических параметров золмитриптана и его активного метаболита выявлено не было.\u003Cbr\u003EРезультаты исследований с участием здоровых добровольцев свидетельствуют об отсутствии фармакокинетического и клинически значимого взаимодействия золмитриптана и эрготамина. Однако из-за теоретического риска коронарного ангиоспазма совместное применение этих препаратов противопоказано. Рекомендуется применять золмитриптан не ранее чем через 24 часа после приема препаратов эрготамина или его производных.\u003Cbr\u003EПосле применения моклобемида (ингибитор МАО-А) отмечалось небольшое увеличение (на 26 %) AUC золмитриптана и трехкратное увеличение AUC его активного метаболита.\u003Cbr\u003EПосле приема циметидина, ингибитора цитохрома Р450, отмечалось увеличение периода полувыведения золмитриптана на 44 % и увеличение AUC на 48 %. Период полувыведения и AUC активного N-дезметилированного метаболита увеличивались вдвое. Поэтому для пациентов, принимающих циметидин, суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг. Основываясь на общем профиле взаимодействия золмитриптана, нельзя исключить возможность его взаимодействия с ингибиторами изофермента CYP1A2 цитохрома Р450. Поэтому для пациентов, принимающих селективные ингибиторы изофермента CYP1A2 (например, флувоксамин, ципрофлоксацин и другие хинолоны), суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг.\u003Cbr\u003EФармакокинетическое взаимодействие золмитриптана с селегилином (ингибитор МАО-В) и флуоксетином (селективный ингибитор обратного захвата серотонина (СИОЗС) не было подтверждено. Однако при одновременном применении триптанов и СИОЗС или СИОЗСиН (селективных ингибиторов обратного захвата серотонина и норадреналина) были описаны случаи развития серотонинового синдрома (см. раздел \"Особые указания\").\u003Cbr\u003EКак и другие агонисты серотониновых 5НТ1B/1D-рецепторов, золмитриптан может замедлять абсорбцию других лекарственных средств.\u003Cbr\u003EПобочные эффекты могут быть более частыми при совместном приеме триптанов и растительных препаратов, содержащих зверобой продырявленный (Hypericum perforatum)."},{"name":"Регистрационный номер","value":"ЛП-006004"},{"name":"Дата государственной регистрации","value":"23.12.2019"},{"name":"Владелец регистрационного удостоверения","value":"Северная Звезда","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:16002862"]}}},{"name":"Изготовитель","value":"Северная Звезда"},{"name":"Фасовщик","value":"Северная Звезда"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Золмитриптан-СЗ","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:20429831"]}}},{"name":"Срок годности","value":"777 дн."}]}},"fullSpecsGrouped":{"14617455117048540085":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Рецептурный препарат","value":"да"},{"name":"Органы и системы","value":"нервная система"},{"name":"Назначение","value":"мигрень"},{"name":"Показания к применению","value":"Купирование приступов мигрени с аурой или без ауры."},{"name":"Противопоказания","value":"Гиперчувствительность к любым компонентам препарата.\u003Cbr\u003EДетский возраст - до 18-ти лет.\u003Cbr\u003EПожилой возраст - старше 65 лет (эффективность и безопасность применения не изучена).\u003Cbr\u003EПериод беременности (безопасность применения не изучена).\u003Cbr\u003EГемиплегическая, базилярная и офтальмоплегическая мигрень. Неконтролируемая артериальная гипертензия.\u003Cbr\u003EИшемическая болезнь сердца.\u003Cbr\u003EКоронарный вазоспазм / стенокардия Принцметала.\u003Cbr\u003EЗаболевания периферических артерий.\u003Cbr\u003EНарушение мозгового кровообращения (в том числе, инсульт или транзиторная ишемическая атака) в анамнезе.\u003Cbr\u003EСиндром Вольфа-Паркинсона-Уайта или аритмии, ассоциированные с другими дополнительными путями проведения импульса.\u003Cbr\u003EТяжелая почечная недостаточность (клиренс креатинина менее 15 мл/мин).\u003Cbr\u003EСовместное применение с другими агонистами серотониновых 5HТ1b/1d- рецепторов (например, суматриптаном, наратриптаном), эрготамином или его производными (в том числе, метизергидом), а также в течение 24 часов после их отмены.\u003Cbr\u003EСовместное применение с ингибиторами МАО-А и в течение 14 дней после их отмены.\u003Cbr\u003EНепереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция."},{"name":"Состав","value":"1 таблетка содержит: действующее вещество: золмитриптан - 2,5 мг; вспомогательные вещества: лактоза безводная (сахар молочный безводный) - 98,3 мг, целлюлоза микрокристаллическая (тип 102) - 15,0 мг, карбоксиметилкрахмал натрия - 3,0 мг, магния стеарат -1,2 мг; состав оболочки: гипромеллоза - 2,15 мг, полисорбат-80 (твин-80) - 0,60 мг, тальк - 0,60 мг, титана диоксид Е 171 - 0,45 мг, краситель железа оксид желтый Е 172 - 0,20 мг."},{"name":"Действующее вещество","value":"Золмитриптан"},{"name":"Способ применения и дозы","value":"Таблетки следует принимать внутрь целиком, запивая водой.\u003Cbr\u003EРекомендуемая доза препарата для снятия приступа мигрени - 2,5 мг (1 таблетка). Рекомендуется принимать препарат как можно раньше с момента начала головной боли, однако препарат эффективен и при приеме в более поздние сроки после начала приступа.\u003Cbr\u003EЕсли симптомы мигрени возникают вновь в течение 24 часов, можно принять повторную дозу препарата Золмитриптан-СЗ. Не следует принимать повторную дозу ранее, чем через 2 часа после приема первой дозы. Если после приема первой дозы не отмечено клинического эффекта, маловероятна польза от повторного приема препарата во время того же приступа.\u003Cbr\u003EЕсли у пациента не был достигнут терапевтический эффект после приема дозы 2,5 мг, для снятия последующих приступов мигрени можно применять препарат Золмитриптан-СЗ в дозе 5 мг (2 таблетки).\u003Cbr\u003EНе следует принимать более 2 доз препарата Золмитриптан-СЗ в сутки. Суммарная доза золмитриптана, принятая в течение суток, не должна превышать 10 мг (4 таблетки).\u003Cbr\u003EПрепарат Золмитриптан-СЗ не показан для профилактики мигрени.\u003Cbr\u003EПрименение у особых групп пациентов\u003Cbr\u003EДетский и подростковый возраст\u003Cbr\u003EЭффективность и безопасность применения золмитриптана у детей до 12 лет не изучалась. Эффективность применения золмитриптана в плацебоконтролируемом клиническом исследовании у пациентов в возрасте от 12 до 17 лет не установлена. Применение препарата Золмитриптан-СЗ у детей и подростков не рекомендуется.\u003Cbr\u003EПожилой возраст\u003Cbr\u003EЭффективность и безопасность золмитриптана у пациентов старше 65 лет не установлена. Поэтому применение препарата Золмитриптан-СЗ у пациентов пожилого возраста не рекомендуется.\u003Cbr\u003EНарушение функции печени\u003Cbr\u003EКоррекция дозы при легком и умеренном нарушении функции печени не требуется. Для пациентов с тяжелым нарушением функции печени суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг.\u003Cbr\u003EПочечная недостаточность\u003Cbr\u003EКоррекция дозы не требуется, если клиренс креатинина выше 15 мл/мин. Препарат противопоказан при почечной недостаточности тяжелой степени тяжести (клиренс креатинина менее 15 мл/мин).\u003Cbr\u003EВзаимодействие с другими лекарственными средствами, требующее коррекции дозы\u003Cbr\u003EДля пациентов, принимающих циметидин или селективные ингибиторы изофермента CYP1A2 (например, флувоксамин, ципрофлоксацин и другие хинолоны) суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг."},{"name":"Побочные действия","value":"Нежелательные реакции при применении золмитриптана, как правило, возникают в течение 4 часов после приема препарата, носят транзиторный характер и разрешаются спонтанно без лечения. Частота нежелательных реакций не увеличивается при приеме повторных доз.\u003Cbr\u003EЧастота развития нежелательных реакций представлена согласно классификации ВОЗ: очень часто (≥1/10 случаев); часто (≥1/100 и \u003C1/10 случаев); нечасто (≥1/1000 и \u003C1/100 случаев); редко (≥1/10000 и \u003C1/1000 случаев); очень редко (\u003C1/10000 случаев).\u003Cbr\u003EСо стороны центральной нервной системы: часто - нарушения чувствительности, головокружение, гиперестезия, парестезии, сонливость, ощущение \"тепла\" или \"холода\", вертиго.\u003Cbr\u003EСо стороны сердечно-сосудистой системы: часто - ощущение сердцебиения; нечасто - тахикардия, незначительное повышение артериального давления, транзиторное повышение артериального давления; очень редко - инфаркт миокарда, стенокардия, коронарный ангиоспазм.\u003Cbr\u003EСо стороны желудочно-кишечного тракта: часто - боль в животе; тошнота, рвота, сухость во рту, диспепсия, дисфагия; очень редко - ишемия или инфаркт (например, ишемия или инфаркт кишки, инфаркт селезенки), симптомами которых могут быть диарея с примесью крови и боль в животе.\u003Cbr\u003EСо стороны костно-мышечной системы: часто - мышечная слабость, миалгия.\u003Cbr\u003EСо стороны мочевыделительной системы: нечасто - полиурия, частое мочеиспускание; очень редко - императивные позывы к мочеиспусканию.\u003Cbr\u003EСо стороны иммунной системы: редко - реакции гиперчувствительности, в том числе, крапивница, ангионевротический отек и анафилактические реакции.\u003Cbr\u003EОбщие расстройства: часто - астения, инертность, чувство стеснения дыхания, боль или чувство стеснения в глотке, области шеи, грудной клетке или конечностях, повышенное потоотделение.\u003Cbr\u003EНекоторые из перечисленных симптомов могут быть симптомами мигрени.\u003Cbr\u003EЕсли любые из указанных в инструкции нежелательные реакции усугубляются, или Вы заметили другие нежелательных реакций не указанные в инструкции, сообщите об этом врачу."},{"name":"Фармакологическое действие","value":"Золмитриптан является селективным агонистом 5НТ1B/1D-рецепторов, стимуляция которых приводит к вазоконстрикции. Обладает высоким сродством к рекомбинантным 5НТ1B/1D-рецепторам человека и умеренным сродством к 5НТ1A-рецепторам. Золмитриптан не обладает сродством и не проявляет существенной фармакологической активности по отношению к 5HT2, 5НТ3, 5НТ4, адренергическим, гистаминовым, мускариновым и дофаминергическим рецепторам.\u003Cbr\u003EВведение золмитриптана лабораторным животным приводило к вазоконстрикции в бассейне сонной артерии. Кроме того, результаты исследований на лабораторных животных свидетельствуют о том, что золмитриптан блокирует центральную и периферическую активность тройничного нерва за счет ингибирования высвобождения пептида, связанного с геном кальцитонина, вазоактивного интестинального пептида и субстанции Р.\u003Cbr\u003EВ клинических исследованиях эффект золмитриптана в отношении головной боли и других симптомов мигрени (таких как тошнота, фотофобия, фонофобия) отмечался через 1 час и нарастал в период от 2 до 4 часов после приема препарата.\u003Cbr\u003EЗолмитриптан одинаково эффективен в отношении мигрени с аурой, мигрени без ауры и мигрени, ассоциированной с менструацией. Прием золмитриптана во время ауры не предотвращал мигренозной головой боли, поэтому препарат следует принимать после начала болевого приступа."},{"name":"Фармакологическая группа","value":"противомигренозное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы\u003Cbr\u003EПри однократном приеме внутрь золмитриптана в дозе 50 мг здоровыми добровольцами обычно отмечался седативный эффект. Период полувыведения золмитриптана составляет 2,5 - 3 часа, поэтому при передозировке наблюдение за пациентом должно продолжаться, как минимум в течение 15 часов или пока имеются симптомы передозировки.\u003Cbr\u003EЛечение\u003Cbr\u003EДля золмитриптана нет специфического антидота. В случае выраженной интоксикации рекомендуются мероприятия интенсивной терапии, включая восстановление и поддержание проходимости дыхательных путей, обеспечение адекватной оксигенации и вентиляции легких, а также наблюдение и поддержку функции сердечно-сосудистой системы.\u003Cbr\u003EЭффект гемодиализа и перитонеального диализа в отношении концентрации золмитриптана в сыворотке не установлен."},{"name":"Применение при беременности и кормлении грудью","value":"Безопасность применения золмитриптана во время беременности не изучалась. Результаты исследований на животных не выявили прямых тератогенных эффектов. Однако, некоторые данные исследований эмбриотоксичности свидетельствуют о возможном снижении жизнеспособности эмбрионов. Применение препарата противопоказано в период беременности.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EЗолмитриптан проникает в молоко лактирующих животных. Неизвестно, проникает ли золмитриптан в грудное молоко женщин в период грудного вскармливания. Поэтому необходимо с осторожностью подходить к вопросу назначения препарата женщинам в период грудного вскармливания. Прекращение грудного вскармливания на 24 часа позволяет минимизировать воздействие золмитриптана на грудного ребенка."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Не наблюдалось значительного ухудшения в выполнении психомоторных тестов при приеме золмитриптана в дозе до 20 мг. Пациентам, деятельность которых требует высокой скорости психомоторных реакций (например, управление транспортным средством или механизмами), рекомендуется соблюдать осторожность из-за возможного развития сонливости и других симптомов мигрени."},{"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EТяжелое нарушение функции печени.\u003Cbr\u003EПрепарат Золмитриптан-СЗ может применяться только в случаях четко диагностированной мигрени. До назначения золмитриптана, как и других средств для купирования мигрени, необходимо исключить другие возможные серьезные неврологические заболевания у пациентов с ранее не диагностированной мигренью, а также у пациентов с установленным диагнозом мигрени при наличии атипичных симптомов. Золмитриптан не показан для лечения гемиплегической, базилярной и офтальмоплегической мигрени. У пациентов, принимающих агонисты серотониновых 5НТш/т- рецепторов, отмечались нарушения мозгового кровообращения, в том числе, инсульты. Пациенты с мигренью могут быть подвержены риску развития определенных нарушений мозгового кровообращения.\u003Cbr\u003EНе следует применять золмитриптан у пациентов с синдромом Вольфа-Паркинсона-Уайта или аритмиями, ассоциированными с другими дополнительными путями проведения импульса.\u003Cbr\u003EОчень редко при применении данного класса препаратов (агонисты серотониновых 5НТ1b/1d -рецепторов) отмечались коронарный ангиоспазм, стенокардия и инфаркт миокарда.\u003Cbr\u003EПеред назначением золмитриптана пациентам с факторами риска развития ишемической болезни сердца (ИБС) (например, курение, артериальная гипертензия, гиперлипидемия, сахарный диабет, отягощенный семейный анамнез в отношении ИБС) рекомендуется провести обследование сердечно¬сосудистой системы, необходимо контролировать артериальное давление и электрокардиограмму. Особое внимание следует уделять женщинам в постменопаузальном периоде и мужчинам старше 40 лет при наличии указанных факторов риска. Тем не менее, не у всех пациентов при обследовании удается выявить сердечно-сосудистые заболевания, и в очень редких случаях серьезные сердечно-сосудистые осложнения могут развиться у пациентов, не имевших указаний на сердечно-сосудистые заболевания в анамнезе.\u003Cbr\u003EКак и в случае применения других агонистов серотониновых 5HT1b/1d- рецепторов, при применении золмитриптана сообщалось об ощущениях тяжести, давления или стеснения в области сердца. При возникновении болей в области грудной клетки или симптомов ишемической болезни сердца следует прекратить прием золмитриптана до проведения соответствующего медицинского обследования.\u003Cbr\u003EКак и в случае других агонистов серотониновых 5НТ1b/1d -рецепторов, транзиторное повышение артериального давления отмечалось у пациентов независимо от наличия артериальной гипертензии в анамнезе (очень редко такое повышение артериального давления было клинически выраженным). Не следует превышать рекомендованные дозы золмитриптана.\u003Cbr\u003EПобочные эффекты могут быть более частыми при одновременном приеме триптанов и растительных препаратов, содержащих зверобой продырявленный (Hypericum perforatum).\u003Cbr\u003EОтмечалось развитие серотонинового синдрома при сочетанном применении триптанов и СИОЗС или СИОЗСиН. Серотониновый синдром может включать следующие признаки и симптомы: изменения психического состояния, вегетативные и нервно-мышечные симптомы. Рекомендуется тщательное наблюдение за пациентами при сопутствующем назначении препарата Золмитриптан-СЗ и СИОЗС или СИОЗСиН, особенно в период начала терапии, увеличения дозы или добавления к терапии другого препарата, влияющего на обмен серотонина (см. раздел \"Взаимодействие с другими лекарственными средствами\").\u003Cbr\u003EЧрезмерное применение противомигренозных препаратов может приводить к увеличению частоты возникновения головной боли, что потенциально требует отмены лечения. Если у пациента отмечаются частые или ежедневные головные боли, несмотря на регулярный прием препаратов для лечения этого состояния, следует помнить о возможности развития головной боли при избыточном употреблении лекарственных препаратов для терапии головной боли."},{"name":"Взаимодействие","value":"В исследованиях по изучению взаимодействия золмитриптана с кофеином, эрготамином, дигидроэрготамином, парацетамолом, метоклопрамидом, пизотифеном, флуоксетином, рифампицином и пропранололом клинически значимых изменений фармакокинетических параметров золмитриптана и его активного метаболита выявлено не было.\u003Cbr\u003EРезультаты исследований с участием здоровых добровольцев свидетельствуют об отсутствии фармакокинетического и клинически значимого взаимодействия золмитриптана и эрготамина. Однако из-за теоретического риска коронарного ангиоспазма совместное применение этих препаратов противопоказано. Рекомендуется применять золмитриптан не ранее чем через 24 часа после приема препаратов эрготамина или его производных.\u003Cbr\u003EПосле применения моклобемида (ингибитор МАО-А) отмечалось небольшое увеличение (на 26 %) AUC золмитриптана и трехкратное увеличение AUC его активного метаболита.\u003Cbr\u003EПосле приема циметидина, ингибитора цитохрома Р450, отмечалось увеличение периода полувыведения золмитриптана на 44 % и увеличение AUC на 48 %. Период полувыведения и AUC активного N-дезметилированного метаболита увеличивались вдвое. Поэтому для пациентов, принимающих циметидин, суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг. Основываясь на общем профиле взаимодействия золмитриптана, нельзя исключить возможность его взаимодействия с ингибиторами изофермента CYP1A2 цитохрома Р450. Поэтому для пациентов, принимающих селективные ингибиторы изофермента CYP1A2 (например, флувоксамин, ципрофлоксацин и другие хинолоны), суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг.\u003Cbr\u003EФармакокинетическое взаимодействие золмитриптана с селегилином (ингибитор МАО-В) и флуоксетином (селективный ингибитор обратного захвата серотонина (СИОЗС) не было подтверждено. Однако при одновременном применении триптанов и СИОЗС или СИОЗСиН (селективных ингибиторов обратного захвата серотонина и норадреналина) были описаны случаи развития серотонинового синдрома (см. раздел \"Особые указания\").\u003Cbr\u003EКак и другие агонисты серотониновых 5НТ1B/1D-рецепторов, золмитриптан может замедлять абсорбцию других лекарственных средств.\u003Cbr\u003EПобочные эффекты могут быть более частыми при совместном приеме триптанов и растительных препаратов, содержащих зверобой продырявленный (Hypericum perforatum)."},{"name":"Регистрационный номер","value":"ЛП-006004"},{"name":"Дата государственной регистрации","value":"23.12.2019"},{"name":"Владелец регистрационного удостоверения","value":"Северная Звезда"},{"name":"Изготовитель","value":"Северная Звезда"},{"name":"Фасовщик","value":"Северная Звезда"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Золмитриптан-СЗ"},{"name":"Срок годности","value":"777 дн."}]}],"transitionId":"tr_4667169953704034193"}}}}
Внешний вид товаров и/или упаковки может быть изменён изготовителем и отличаться от изображенных на Яндекс Маркете.
Есть противопоказания, посоветуйтесь с врачом. Отпускается по рецепту врача. Приобретение лекарственных препаратов осуществляется только в торговом зале аптеки

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    на основе 63 оценки
    Цена 133 ₽
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  • Суматриптан-Тева таб. п/о плен., 50 мг, 2 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-d41mw9j71q/toggleWishlist":{"skuId":"101352301730","productId":186857414,"offerId":"TeDrZAxSl65VHK5xdRHF5A","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIxu+MWRCiycXI+QIY1v2NByDt2cEH","sign":"4XrabGkaqq4ANiSMfVvkEEA6cGVqW0d+WEhY+xjjoe4="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-d41mw9j71q/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Суматриптан-Тева таб. п/о плен., 50 мг, 2 шт.

    Рейтинг товара: 5 из 5
    на основе 25 оценок
    Цена 193 ₽
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  • Мигрепам таб. п/о плен., 2.5 мг, 2 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-wq3t402o6wg/toggleWishlist":{"skuId":"101392490731","productId":227814310,"offerId":"VDGnXVKt5d-eYDbFzjfEOw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIptfQbBDrwdrb+QIYsYu6CCDt2cEH","sign":"B/BFyf5T99qFiOeMb5uaqP/6wbXISuhd0AhGf1fVzT8="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-wq3t402o6wg/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Мигрепам таб. п/о плен., 2.5 мг, 2 шт.

    Рейтинг товара: 5 из 5
    на основе 2 оценки
    Цена 423 ₽
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  • Суматриптан таб. п/о плен., 50 мг, 2 шт.
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    Суматриптан таб. п/о плен., 50 мг, 2 шт.

    Рейтинг товара: 5 из 5
    на основе 44 оценки
    Цена 98 ₽
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  • Суматриптан таб. п/о плен., 50 мг, 2 шт.
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    Суматриптан таб. п/о плен., 50 мг, 2 шт.

    Рейтинг товара: 5 из 5
    на основе 20 оценок
    Цена 102 ₽
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  • Релпакс таб. п/о плен., 40 мг, 2 шт.
    –21 %
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    Релпакс таб. п/о плен., 40 мг, 2 шт.

    Рейтинг товара: 5 из 5
    на основе 12 оценок
    Цена 728 ₽ вместо 922
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  • Суматриптан Реневал таб. п/о плен., 100 мг, 2 шт.
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    Суматриптан Реневал таб. п/о плен., 100 мг, 2 шт.

    Рейтинг товара: 4 из 5
    на основе 5 оценок
    Цена 135 ₽
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  • Мигрениум таб. п/о плен., 20 шт.
    –1 %
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    Мигрениум таб. п/о плен., 20 шт.

    Рейтинг товара: 4.9 из 5
    на основе 29 оценок
    С картой  Пэй
    Цена с картой Яндекс Пэй 298 ₽ вместо 301
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  • Релонова таб., 10 мг, 2 шт.
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    Релонова таб., 10 мг, 2 шт.

    Рейтинг товара: 5 из 5
    на основе 7 оценок
    Цена 656 ₽
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  • Фенибут таб., 250 мг, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fn07ut04y2/toggleWishlist":{"skuId":"862513045","productId":1404748601,"offerId":"hlvpHnxI-qsMFeB05zZrKQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIuYbrnQUQlc+jmwMYs+DQByDt2cEH","sign":"jcafQ+1BZ6wVh9kgiSpen+i1B2GawWouDFjGP9wgwWg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-fn07ut04y2/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Фенибут таб., 250 мг, 10 шт.

    Рейтинг товара: 4.8 из 5
    на основе 325 оценок
    Цена 92 ₽
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  • Амигренин таб. п/о плен., 100 мг, 2 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-4g769avz63m/toggleWishlist":{"skuId":"101392496736","productId":186858115,"offerId":"DtHdkGUzVvu-UKBz-4BZQA","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEjEKL0NvbXBldGl0aXZlQW5hbG9nc19NYXJrZXRNb2RlbENhcmRfRnJvbnRTbmlwcGV0MhYIg/WMWRDg8Nrb+QIY2tShBSDt2cEH","sign":"zit7EpLY4nMm6W9kXlu+TZiSKzhqqTa5C80SNwLtqxE="},"waitWishlistCollections":false,"place":{"page":"product","widget":"scrollbox"}}}},"meta":{"/content/page/fancyPage/kkmCarousel/kkmCarousel/content/content/slot-4g769avz63m/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Амигренин таб. п/о плен., 100 мг, 2 шт.

    Рейтинг товара: 5 из 5
    на основе 1 оценка
    Цена 506 ₽
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  • Сумамигрен таб. п/о плен., 50 мг, 2 шт.
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    Сумамигрен таб. п/о плен., 50 мг, 2 шт.

    Рейтинг товара: 5 из 5
    на основе 4 оценки
    Цена 318 ₽
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Инструкция

Показания к применению

Купирование приступов мигрени с аурой или без ауры.

Противопоказания

Гиперчувствительность к любым компонентам препарата.
Детский возраст - до 18-ти лет.
Пожилой возраст - старше 65 лет (эффективность и безопасность применения не изучена).
Период беременности (безопасность применения не изучена).
Гемиплегическая, базилярная и офтальмоплегическая мигрень. Неконтролируемая артериальная гипертензия.
Ишемическая болезнь сердца.
Коронарный вазоспазм / стенокардия Принцметала.
Заболевания периферических артерий.
Нарушение мозгового кровообращения (в том числе, инсульт или транзиторная ишемическая атака) в анамнезе.
Синдром Вольфа-Паркинсона-Уайта или аритмии, ассоциированные с другими дополнительными путями проведения импульса.
Тяжелая почечная недостаточность (клиренс креатинина менее 15 мл/мин).
Совместное применение с другими агонистами серотониновых 5HТ1b/1d- рецепторов (например, суматриптаном, наратриптаном), эрготамином или его производными (в том числе, метизергидом), а также в течение 24 часов после их отмены.
Совместное применение с ингибиторами МАО-А и в течение 14 дней после их отмены.
Непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция.

Способ применения и дозы

Таблетки следует принимать внутрь целиком, запивая водой.
Рекомендуемая доза препарата для снятия приступа мигрени - 2,5 мг (1 таблетка). Рекомендуется принимать препарат как можно раньше с момента начала головной боли, однако препарат эффективен и при приеме в более поздние сроки после начала приступа.
Если симптомы мигрени возникают вновь в течение 24 часов, можно принять повторную дозу препарата Золмитриптан-СЗ. Не следует принимать повторную дозу ранее, чем через 2 часа после приема первой дозы. Если после приема первой дозы не отмечено клинического эффекта, маловероятна польза от повторного приема препарата во время того же приступа.
Если у пациента не был достигнут терапевтический эффект после приема дозы 2,5 мг, для снятия последующих приступов мигрени можно применять препарат Золмитриптан-СЗ в дозе 5 мг (2 таблетки).
Не следует принимать более 2 доз препарата Золмитриптан-СЗ в сутки. Суммарная доза золмитриптана, принятая в течение суток, не должна превышать 10 мг (4 таблетки).
Препарат Золмитриптан-СЗ не показан для профилактики мигрени.
Применение у особых групп пациентов
Детский и подростковый возраст
Эффективность и безопасность применения золмитриптана у детей до 12 лет не изучалась. Эффективность применения золмитриптана в плацебоконтролируемом клиническом исследовании у пациентов в возрасте от 12 до 17 лет не установлена. Применение препарата Золмитриптан-СЗ у детей и подростков не рекомендуется.
Пожилой возраст
Эффективность и безопасность золмитриптана у пациентов старше 65 лет не установлена. Поэтому применение препарата Золмитриптан-СЗ у пациентов пожилого возраста не рекомендуется.
Нарушение функции печени
Коррекция дозы при легком и умеренном нарушении функции печени не требуется. Для пациентов с тяжелым нарушением функции печени суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг.
Почечная недостаточность
Коррекция дозы не требуется, если клиренс креатинина выше 15 мл/мин. Препарат противопоказан при почечной недостаточности тяжелой степени тяжести (клиренс креатинина менее 15 мл/мин).
Взаимодействие с другими лекарственными средствами, требующее коррекции дозы
Для пациентов, принимающих циметидин или селективные ингибиторы изофермента CYP1A2 (например, флувоксамин, ципрофлоксацин и другие хинолоны) суммарная доза золмитриптана, принятая в течение суток, не должна превышать 5 мг.
Полная инструкция
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Золмитриптан-СЗ таб. п/о плен.
Золмитриптан-СЗ таб. п/о плен., 2.5 мг, 10 шт.
4.8
(13)
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1 вопрос
Инструкция

593 ₽

Скидка: 20%
–20 %
Вместо:741 ₽
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4.8
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У продавца:13 оценок·4 отзыва
У всех продавцов:125 оценок·60 отзывов
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user avatar
8 месяцев назад • Римма Абдулганиева • Куплен на Маркете
Достоинства: Не дорого,всегда в наличии
Недостатки: Недостатков нет
Комментарий: Золмитриптан СЗ соотношение цена-качество,хорошо купирует приступы мигрени
user avatar
3 месяца назад • Инкогнито 5961 • Куплен на Маркете
Достоинства: эффективен при мигрени
Недостатки: нет
Комментарий: рекомендую к покупке
user avatar
10 месяцев назад • Вера Иванова • Куплен на Маркете
Комментарий: препарат очень хороший только им и спасаюсь от головной боли
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  • Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.
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    Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.

    Цена 1 733 ₽ вместо 1 999
  • Гилан ультра комфорт увлажн. гл. р-р, 0.3%, 0.4 мл, 50 г, 10 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1417729433_3/content/content/gallery":{"title":"Гилан ультра комфорт увлажн. гл. р-р, 0.3%, 0.4 мл, 50 г, 10 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4493501/img_id518890055591967969.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1538707/img_id7406584760491012505.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCJmrg6QFEKucmNsBGIfe0Acg3NzBBw==","sign":"DJe8h06u+4w3z+nUdQEHVydye/rJdwOp4cWJe6uvgMg="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1417729433_3/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Гилан ультра комфорт увлажн. гл. р-р, 0.3%, 0.4 мл, 50 г, 10 шт.

    Цена 288 ₽ вместо 331
  • ЛимфоТранзит концентрат напитка фл., 100 мл
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_4/content/content/gallery":{"title":"ЛимфоТранзит концентрат напитка фл., 100 мл","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMD4ltEGEI2Jl7wCGNW7oQYg19zBBw==","sign":"zEAdOF3reOBX99cPgwJq85WTTzQ717/ymbOoJUsYz9o="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_4/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 329 ₽ вместо 390
  • Суматриптан Канон таб. п/о плен., 50 мг, 2 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:526991046_5/content/content/gallery":{"title":"Суматриптан Канон таб. п/о плен., 50 мг, 2 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/3861966/img_id2937903221297434501.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/3861966/img_id2937903221297434501.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/3861966/img_id2937903221297434501.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/3861966/img_id2937903221297434501.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/3861966/img_id2937903221297434501.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/3861966/img_id2937903221297434501.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4864337/img_id6321034229752099698.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4864337/img_id6321034229752099698.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4864337/img_id6321034229752099698.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4864337/img_id6321034229752099698.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4864337/img_id6321034229752099698.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4864337/img_id6321034229752099698.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCMb9pPsBELGH68f5AhjOwtkHIO3ZwQc=","sign":"lWKF9iT1HwjXFKhEUuGK1ZM4lt3n9As7IaiBru8yerw="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:526991046_5/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Суматриптан Канон таб. п/о плен., 50 мг, 2 шт.

    Цена 133 ₽
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 1 752 ₽ вместо 3 500
  • Суматриптан-Тева таб. п/о плен., 50 мг, 2 шт.
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    Суматриптан-Тева таб. п/о плен., 50 мг, 2 шт.

    Цена 193 ₽
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    Реклама
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  • Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов
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    Эвалар Чай Эвалар БИО при повышенном содержании мочевой кислоты, 20 фильтр-пакетов

    Цена 194 ₽ вместо 224
  • Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175275_10/content/content/toggleWishlist":{"skuId":"831564747","productId":1778175275,"offerId":"DwKsiI_3skuV5jS1zYZNdw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCKua888GEMvXwowDGIqlugQg59zBBw==","sign":"DADVGobRO7+A0wDkjcAI3cBSPmxSKhQrOimDtAytXIg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175275_10/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.

    Цена 9 356 ₽ вместо 9 450
  • Мигрепам таб. п/о плен., 2.5 мг, 2 шт.
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    Мигрепам таб. п/о плен., 2.5 мг, 2 шт.

    Цена 423 ₽
  • Суматриптан таб. п/о плен., 50 мг, 2 шт.
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    Суматриптан таб. п/о плен., 50 мг, 2 шт.

    Цена 98 ₽
  • Суматриптан таб. п/о плен., 50 мг, 2 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:525320053_13/content/content/gallery":{"title":"Суматриптан таб. п/о плен., 50 мг, 2 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4012462/img_id3998227990666073959.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012462/img_id3998227990666073959.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012462/img_id3998227990666073959.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012462/img_id3998227990666073959.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012462/img_id3998227990666073959.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012462/img_id3998227990666073959.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5204767/img_id8395135269701144407.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5204767/img_id8395135269701144407.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5204767/img_id8395135269701144407.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5204767/img_id8395135269701144407.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5204767/img_id8395135269701144407.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5204767/img_id8395135269701144407.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCPX+vvoBEOnK19v5AhiU39AHIO3ZwQc=","sign":"976xanRmoeQZUkbQldsVej5i9s8msbIw6xdNEGWW1qg="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:525320053_13/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:525320053_13/content/content/toggleWishlist":{"skuId":"101392442729","productId":525320053,"offerId":"trtO1BUzY4Fm4--rB7I6uw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCPX+vvoBEOnK19v5AhiU39AHIO3ZwQc=","sign":"976xanRmoeQZUkbQldsVej5i9s8msbIw6xdNEGWW1qg="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:525320053_13/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Суматриптан таб. п/о плен., 50 мг, 2 шт.

    Цена 102 ₽
  • Релпакс таб. п/о плен., 40 мг, 2 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:538676001_14/content/content/toggleWishlist":{"skuId":"101392357762","productId":538676001,"offerId":"OTKFII7gAAJLv9PAyCeEhQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCKGW7oACEIKz0tv5Ahi7k4wGIO3ZwQc=","sign":"vXAUmAvZC4/Q3zZHNA/QrFIV+UzLt26OuNYKrQUQsVU="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:538676001_14/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Релпакс таб. п/о плен., 40 мг, 2 шт.

    Цена 728 ₽ вместо 922
  • IKENA Нафтифин р-р противогрибковый фл., 1%, 37 г, 10 мл, 1 шт., нейтральный, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1697497178_15/content/content/toggleWishlist":{"skuId":"101618007386","productId":1697497178,"offerId":"iqtqSf-sBfwRtDaaagRYUQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQgsaf8IbajcYEEhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCNqAt6kGENr6nsf6AhjVu6EGIOHZwQc=","sign":"WA90mr8KlcSIqErF7MFTtIG7fIbPJq8yZOObNNDyk4A="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1697497178_15/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    IKENA Нафтифин р-р противогрибковый фл., 1%, 37 г, 10 мл, 1 шт., нейтральный, 1 уп.

    Цена 399 ₽ вместо 480
  • Мизол спрей, 50 мл
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    Мизол спрей, 50 мл

    Цена 734 ₽ вместо 815
  • Акриол Про крем д/мест. и нар. прим., 2,5%+2,5%, 5 г
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    Акриол Про крем д/мест. и нар. прим., 2,5%+2,5%, 5 г

    Цена 315 ₽ вместо 356
  • Симбикорт турбухалер пор. д/инг. дозир., 80 мкг+4.5 мкг/доза, 60 шт.
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    Симбикорт турбухалер пор. д/инг. дозир., 80 мкг+4.5 мкг/доза, 60 шт.

    Цена 1 114 ₽
  • Гилан Комфорт увлажн. гл. р-р, 0.18%, 0.4 мл, 30 шт.
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    Гилан Комфорт увлажн. гл. р-р, 0.18%, 0.4 мл, 30 шт.

    Цена 359 ₽
  • Кетоконазол шампунь лекарственный, 2%, 75 г, 75 мл
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    Кетоконазол шампунь лекарственный, 2%, 75 г, 75 мл

    Цена 319 ₽ вместо 322
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    Реклама
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  • Суматриптан Реневал таб. п/о плен., 100 мг, 2 шт.
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    Суматриптан Реневал таб. п/о плен., 100 мг, 2 шт.

    Цена 135 ₽
  • Мигрениум таб. п/о плен., 20 шт.
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    Мигрениум таб. п/о плен., 20 шт.

    Цена 298 ₽ вместо 301
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