Яндекс Маркет

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Яндекс Яндекс

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Марина Аравина

7 отзывов

0 ответов

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Ценитель здоровья 4 уровня

Здоровье

Мастер быта 3 уровня

Бытовая техника

Все уровни

3 достижения

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Угловой диван Много мебели Атланта НПБ

Марина Аравина

8 месяцев назад

Рейтинг: 1Рейтинг: 2Рейтинг: 3Рейтинг: 4Рейтинг: 5

Отличный товар

Служит уже 15 лет, эко кожа слеза, перетянули, в нутри как новый.

Утюг MARTA MT-IR1155A

Марина Аравина

8 месяцев назад

Рейтинг: 1Рейтинг: 2Рейтинг: 3Рейтинг: 4Рейтинг: 5

Хороший товар

Гладит)))

Фенофибрат Канон таб. п/о плен.

Марина Аравина

8 месяцев назад

Рейтинг: 1Рейтинг: 2Рейтинг: 3Рейтинг: 4Рейтинг: 5

Отличный товар

Мама пьёт регулярного.

Апровель таб. п/о плен.

Марина Аравина

11 месяцев назад

Рейтинг: 1Рейтинг: 2Рейтинг: 3Рейтинг: 4Рейтинг: 5

Отличный товар

Пьёт мама, говорит помогает.

Цикловита таб. п/о

Марина Аравина

11 месяцев назад

Рейтинг: 1Рейтинг: 2Рейтинг: 3Рейтинг: 4Рейтинг: 5

Отличный товар

Отличный витаминный комплекс для женщин с нарушением менструального цикла. Пью уже больше 5 лет, раз в год 3 месяца. Все отлично и цикл тоже.

Мини-печь Simfer Albeni Comfort M3430/M3418/M3419/M3412/M3426/M3402/M3428/M3426TB

Марина Аравина

11 месяцев назад

Рейтинг: 1Рейтинг: 2Рейтинг: 3Рейтинг: 4Рейтинг: 5

Отличный товар

Подарила детям в квартиру студию. Удобная, компактная, печет очень хорошо. Доча довольна.

Сухой корм для собак ARO говядина, курица

Марина Аравина

2 года назад

Рейтинг: 1Рейтинг: 2Рейтинг: 3Рейтинг: 4Рейтинг: 5

Плохой товар

за не имением лучшего на пару раз пойдет.

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в дополнительном источнике витаминов и минералов у женщин может возникать при повышенных нагрузках, в период перед менструациями, после перенесенных гинекологических заболеваний, во время длительного приема гормональных контрацептивов и многих других ситуациях.\u003Cbr /\u003E"},{"description":"","filters":[{"id":15777995,"name":"Противопоказания"}],"isMainProperty":false,"name":"Противопоказания","value":"Индивидуальная непереносимость компонентов, беременность, кормление грудью."},{"description":"","filters":[{"id":15777997,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"Состав ЦИКЛОВИТА® 1: наполнитель сахар, аскорбиновая кислота (витамин С), разрыхлитель крахмал, цинк сернокислый 7-водный, наполнитель каолин, рутин, α- токоферола ацетат (витамин Е), никотинамид, рибофлавин (витамин В2), пиридоксина гидрохлорид (витамин В6), кальция пантотенат, тиамина гидрохлорид (витамин В1), липоевая кислота (тиоктовая кислота), марганец сернокислый 5-водный, лютеин, фолиевая кислота, ретинола ацетат (витамин А), натрия селенит, цианокобаламин (витамин В12), витамин D3, корригент цвета двуокись титана, связующее вещество: гуммиарабик, поливинилпирролидон; пролонгатор шеллак, скользящее вещество: тальк, кальция стеарат; разрыхлитель лимонная кислота, краситель: «Солнечный закат», хинолиновый желтый; глазирователь воск пчелиный.\u003Cbr /\u003EСодержит краситель, который может оказывать отрицательное влияние на активность и внимание детей.\u003Cbr /\u003E% от рекомендуемого уровня суточного потребления1 / % от адекватного уровня потребления* в одной таблетке ЦИКЛОВИТА® 1:\u003Cbr /\u003EВитамин С** 200 мг (333%), рутин 30 мг (100%*), витамин Е** 15 мг (150%), цинк 12 мг (80%), никотинамид 8 мг (44%), витамин В2** 5 мг (313%), витамин В6** 5 мг (250%), кальция пантотенат 5 мг (83%), витамин В1** 4 мг (286%), липоевая кислота 3 мг (10%*), марганец** 2,5 мг (125%*), лютеин 0,5 мг (10 %*), фолиевая кислота** 400 мкг (200%), витамин А 0,17 мг (500 МЕ) (21%), селен 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Максимальная суточная доза: 300 мг в сутки.\u003Cbr\u003EПрименение у отдельных групп пациентов\u003Cbr\u003EДети и подростки до 18 лет: применение препарата противопоказано (недостаточно клинических данных по безопасности и эффективности препарата).\u003Cbr\u003EПациенты пожилого возраста (старше 65 лет): коррекции дозы не требуется.\u003Cbr\u003EПациенты с нарушением функции почек: коррекции дозы не требуется.\u003Cbr\u003EПациенты с нарушением функции печени: у пациентов с нарушением функции печени лёгкой и умеренной степени тяжести (5-9 баллов по шкале Чайлд-Пью) коррекции дозы не требуется. Опыт применения препарата у пациентов с тяжелой печеночной недостаточностью отсутствует.\u003Cbr\u003EПациенты с гиповолемией: у пациентов с выраженной гиповолемией и/или гипонатриемией, таких как пациенты, получающие интенсивную диуретическую терапию, или находящиеся на гемодиализе, гиповолемия и гипонатриемия должны быть скорректированы до начала применения препарата Апровель."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Безопасность препарата Апровель изучалась в клинических исследованиях приблизительно у 5000 пациентов, включая 1300 пациентов с артериальной гипертензией, принимавших препарат в течение более 6 месяцев, и 400 пациентов, принимавших препарат в течение одного года и более.\u003Cbr\u003EНежелательные явления у пациентов, принимавших препарат Апровель, обычно были умеренно выраженными и преходящими, и их частота не была связана с величиной принимаемой дозы. Частота возникновения нежелательных явлений не зависела от пола, возраста и расовой принадлежности.\u003Cbr\u003EВ плацебо-контролируемых исследованиях, в которых 1965 пациентов принимали ирбесартан (в среднем, в течение 1-3 месяцев), прекращение лечения из-за развития каких- либо клинических или лабораторных нежелательных явлений потребовалось у 3,3% пациентов, принимавших препарат Апровель, и у 4,5% пациентов, принимавших плацебо (различия были статистически достоверны).\u003Cbr\u003EУ пациентов с нефропатией при артериальной гипертензии и сахарном диабете 2 типа (клинические исследования IDNT и IRMA 2) нежелательные явления подобны таковым у пациентов с артериальной гипертензией, за исключением ортостатических симптомов (головокружение (10,2%) (при приеме плацебо 6%), ортостатическое головокружение (5,4%) (при приеме плацебо 2,7%) и ортостатическая гипотензия (5,4%) (при приеме плацебо 3,2%).\u003Cbr\u003EПроцент прекращения лечения из-за ортостатических симптомов при приеме препарата Апровель, по сравнению с плацебо, составлял для головокружения 0,3% против 0,5%, для ортостатического головокружения 0,2% против 0,0% и для ортостатической гипотензии 0,0% против 0,0%, соответственно.\u003Cbr\u003EЧастота возникновения нежелательных реакций определялась в соответствии с классификацией Всемирной Организации Здравоохранения (ВОЗ): очень часто (≥ 1/10); часто (≥ 1/100 и \u003C 1/10); нечасто (≥ 1/1000 и \u003C 1/100); редко (≥ 1/10000 и \u003C 1/1000); очень редко (\u003C 1/10000), частота неизвестна (не может быть подсчитана на основании имеющихся данных).\u003Cbr\u003EНиже представлены нежелательные реакции, наблюдавшиеся в клинических исследованиях у пациентов с артериальной гипертензией, у пациентов с нефропатией при артериальной гипертензии и сахарном диабете типа (клинические исследования IDNT и IRMA ) или при пострегитсрационном применении препарата.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003Eчастота неизвестна: тромбоцитопения, в том числе тромобоцитопеническая пурпура.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eчастота неизвестна: реакции гиперчувствителыюсти (такие как ангионевротический отек, кожная сыпь, крапивница, анафилактические реакции, анафилактический шок).\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eчастота неизвестна: гиперкалиемия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eчасто: головокружение,, ортостатическое головокружение, головная боль;\u003Cbr\u003Eнечасто: ортостатическое головокружение;\u003Cbr\u003Eчастота неизвестна: вертиго.\u003Cbr\u003EНарушения со стороны органа слуха:\u003Cbr\u003Eчастота неизвестна: звон в ушах.\u003Cbr\u003EНарушения со стороны сердца:\u003Cbr\u003Eнечасто: отеки, тахикардия.\u003Cbr\u003EНарушения со стороны сосудов:\u003Cbr\u003Eчасто: ортостатическая гипотензия;\u003Cbr\u003Eнечасто: приливы крови.\u003Cbr\u003EНарушения со стороны дыхательной системы органов грудной клетки и средостения:\u003Cbr\u003Eнечасто: кашель.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eчасто: тошнота, рвота; нечасто: диарея, диспепсия, изжога;\u003Cbr\u003Eчастота неизвестна: дисгевзия.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003Eнечасто: желтуха;\u003Cbr\u003Eчастота неизвестна: повышение активности \"печеночных\" ферментов и концентрации билирубина в крови, гепатит.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003Eчастота неизветна: лейкоцитокластический васкулит, псориаз, в том числе усиление проявления симптомов псориаза (см. раздел \"Особые указания\"), реакции фоточувствительности.\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr\u003Eчасто: мышечно-скелетная боль;\u003Cbr\u003Eчастота неизвестна: миалгия (в некоторых случаях может быть сопряжена с повышением концентрации креатинкиназы в плазме крови), артралгия, мышечные спазмы.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eчастота неизвестна: нарушение функции почек, в том числе случаи развития почечной недостаточности у пациентов группы риска (см. раздел \"Особые указания\").\u003Cbr\u003EНарушения со стороны половых органов и молочной железы:\u003Cbr\u003Eнечасто: половая дисфункция.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eчасто: повышенная утомляемость; нечасто: боль в грудной клетке;\u003Cbr\u003Eчастота неизвестна: астения.\u003Cbr\u003EЛабораторные и инструментальные данные:\u003Cbr\u003EВо время проведения контролиролируемых клинических исследований у пациентов с артериальной гипертензией не наблюдалось клинически значимых изменений в лабораторных показателях. Не требуется специального мониторинга лабораторных показателей для пациентов с артериальной гипертензией, принимающих препарат Апровель.\u003Cbr\u003EГиперкалиемия2: в клиническом исследовании IDNT процент пациентов с гиперкалиемией (\u003E 6 мЭкв/л) составил 18,6% в группе препарата Апровель по сравнению с 6,0% в группе плацебо. В клиническом исследовании IRMA 2 процент пациентов с гиперкалиемией (\u003E 6 мЭкв/л) составил 1,0% в группе препарата Апровель, а в группе плацебо гиперкалиемии не наблюдалось. В клиническом исследовании IDNT частота прекращения лечения из-за развития гиперкалиемии при применении препарата Апровель и плацебо составляла 2,1% и 0,36%, соответственно. В клиническом исследовании IRMA частота прекращения лечения из-за развития гиперкалиемии при приеме препарата Апровель и плацебо составляла 0,5% и 0%, соответственно."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Ирбесартан является селективным антагонистом рецепторов ангиотензина II (типа АТ|).\u003Cbr\u003EИрбесартан не требует метаболической активации для приобретения фармакологической активности. Ангиотензин II является важным компонентом ренин-ангиотензин-альдостероновой системы (РААС) и вовлечен в патогенез развития артериальной гипертензии, а также гомеостаз натрия.\u003Cbr\u003EИрбесартан блокирует все физиологически значимые эффекты ангиотензина II, независимо от источника или пути его синтеза, в том числе, его сильно выраженные сосудосуживающий и альдостероносекретирующий эффекты, реализующиеся через рецепторы типа AT1, расположенные на поверхности гладкомышечных клеток сосудов и в коре надпочечников. Ирбесартан не обладает агонистической активностью к АТ1 рецепторам и имеет гораздо большее (более чем в 8500 раз) сродство к AT1-рецепторам, чем с АТ2-рецепторами (рецепторам, не связанным с регуляцией работы сердечнососудистой системы).\u003Cbr\u003EИрбесартан не ингибирует ферменты РААС (такие как ренин, ангиотензинпревращающий фермент [АПФ]) и не влияет на рецепторы других гормонов или ионные каналы, участвующие в регуляции артериального давления (АД) и гомеостаза натрия. Блокирование ирбесартаном AT1-рецепторов прерывает цепь обратной связи в системе ренин-ангиотензин, что приводит к увеличению плазменных концентраций ренина и ангиотензина II. После приема ирбесартана в рекомендуемых дозах плазменная концентрация альдостерона снижается, не оказывая при этом существенного влияния на содержание калия в сыворотке крови (среднее значение его увеличения составляет \u003C0,1мЭкв/л).\u003Cbr\u003EИрбесартан не оказывает заметного влияния на сывороточные концентрации триглицеридов, холестерина и глюкозы.\u003Cbr\u003EИрбесартан не влияет на концентрацию мочевой кислоты в сыворотке крови или на скорость экскреции мочевой кислоты почками.\u003Cbr\u003EАнтигипертензивный эффект ирбесартана проявляется уже после приема его первой дозы и становится значимым в течение 1-2 недель приема, его максимальный антигипертензивный эффект достигается к 4-6 неделе лечения. В долгосрочных клинических исследованиях наблюдалось сохранение антигипертензивного эффекта ирбесартана более одного года.\u003Cbr\u003EПри однократном приеме внутрь ирбесартана в дозах до 900 мг антигипертензивный эффект носит дозозависимый характер в течение суток. Ирбесартан при однократном приеме в дозах 150-300 мг в течение суток снижает АД, измеряемое в положении \"лежа\" или \"сидя\" в конце междозового интервала (через 24 ч после приема дозы ирбесартана, т. е., перед приемом очередной дозы ирбесартана), в среднем на 8-13/5-8 мм рт. ст. (систолическое/диастолическое АД) по сравнению с плацебо. Антигипертензивный эффект ирбесартана перед приемом очередной дозы составляет 60-70% от максимальных значений снижения диастолического и систолического АД. Оптимальное снижение АД в течение 24 ч достигается при приеме ирбесартана один раз в сутки.\u003Cbr\u003EИрбесартан приблизительно в одинаковой степени снижает АД в положении \"стоя\" и в положении \"лежа\". Ортостатические эффекты наблюдаются редко, однако, как и при приеме ингибиторов АПФ. у пациентов с гипонатриемией и/или гиповолемией возможно чрезмерное снижение АД с клиническими проявлениями.\u003Cbr\u003EАнтигипертензивное действие ирбесартана и тиазидных диуретиков носит аддитивный характер. У пациентов с недостаточным снижением АД при монотерапии ирбесартаном добавление к его приему низких доз гидрохлоротиазида (12,5 мг) один раз в сутки приводит к дополнительному снижению АД на 7-10/3-6 мм рт. ст. (систолическое/диастолическое) по сравнению с добавлением плацебо.\u003Cbr\u003EЭффективность ирбесартана не зависит от возраста или пола. Как и при применении других лекарственных средств, которые влияют на РААС, антигипертензивное действие ирбесартана у пациентов негроидной расы заметно менее выражено, однако, при применении ирбесартана одновременно с низкими дозами гидрохлоротиазида (например, 12,5 мг в сутки) антигипертензивный ответ у пациентов негроидной расы приближается по эффективности к таковому у пациентов европеоидной расы.\u003Cbr\u003EПосле отмены ирбесартана АД возвращается к исходному уровню постепенно. Синдрома \"отмены\" не наблюдается.\u003Cbr\u003EУ пациентов с артериальной гипертензией и с сахарным диабетом 2 типа, принимающих ирбесартан в дозировке 300 мг, отмечалось 20% снижение (по сравнению с плацебо) и 23% снижение (по сравнению с амлодипином в дозировке 10 мг) относительного риска первого возникновения любого из следующих состояний: удвоение сывороточной концентрации креатинина, развитие терминальной стадии почечной недостаточности или смерти от любой из причин (при достижении сопоставимого снижения АД при применении ирбесартана и амлодипина)."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"ангиотензина II рецепторов антагонист"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Хранить при температуре не выше 30 °С. Хранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Опыт применения препарата у взрослых пациентов в дозах до 900 мг/сутки на протяжении 8 недель не выявил какой-либо токсичности.\u003Cbr\u003EОтсутствует какая-либо специфическая информация в отношении лечения передозировки препаратом Апровель®. Следует установить постоянное наблюдение за состоянием пациента и, при необходимости, проводить симптоматическую и поддерживающую терапию. При передозировке рекомендуется вызвать рвоту и/или провести промывание желудка. Ирбесартан не выводится из организма с помощью гемодиализа."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Беременность\u003Cbr\u003EОпыт по применению ирбесартана при беременности отсутствует. С учетом того, что при приеме ингибиторов АПФ беременными женщинами во II и III триместрах беременности наблюдались повреждение и гибель развивающегося плода, ирбесартан, как и любой другой препарат, который воздействует непосредственно на РААС, нельзя применять во время беременности (I, II, III триместры).\u003Cbr\u003EПри диагностировании беременности во время лечения ирбесартаном следует как можно скорее прекратить его прием.\u003Cbr\u003EПериод грудного вскармливания\u003Cbr\u003EИрбесартан экскретируется в молоко лактирующих крыс. Неизвестно, может ли ирбесартан/его метаболиты экскретироваться в грудное молоко человека. Во время грудного вскармливания прием ирбесартана противопоказан. Поэтому после оценки соотношения предполагаемой пользы от приема препарата для матери и потенциального риска для ребенка следует прекратить или грудное вскармливание, или прием ирбесартана.\u003Cbr\u003EФертильность\u003Cbr\u003EВ исследованиях у самцов и самок крыс ирбесартан не влиял на фертильность и репродуктивную функцию, даже в дозах, оказывающих некоторое токсическое действие на родителей (до 650 мг/кг/день). Не наблюдалось значимого действия на количество желтых тел, имплантируемых эмбрионов или живых плодов. Ирбесартан не влиял на выживаемость, развитие или воспроизводство потомства."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Влияние препарата на способность управлять транспортными средствами или заниматься другими потенциально опасными видами деятельности, требующими повышенного внимания и высокой скорости психомоторных реакций, не изучалось. Однако, исходя из его фармакодинамических свойств, препарат не должен влиять на способность управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности (работа на высоте, работа авиадиспетчера, работа с механизмами и т.п.). В случае возникновения головокружения и слабости возможно снижение внимания и замедление психомоторных реакций, необходимо соблюдать осторожность при управлении транспортными средствами, механизмами."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003E- При стенозе аортального или митрального клапана или гипертрофической обструктивной кардиомиопатии (ГОКМП);\u003Cbr\u003E- при гиповолемии, гипонатриемии, возникающих, например, при интенсивной диуретической терапии, гемодиализе, соблюдении диеты с ограничением потребления поваренной соли, диарее, рвоте (опасность чрезмерного снижения АД);\u003Cbr\u003E- у пациентов с функцией почек, зависящей от активности РААС, таких как пациенты с артериальной гипертензией с двусторонним или односторонним стенозом почечных артерий или пациенты с хронической сердечной недостаточностью III-IV функционального класса (по классификации NYHA) (см. раздел \"Особые указания\");\u003Cbr\u003E- при ишемической болезни сердца и/или клинически значимом атеросклерозе сосудов головного мозга (при чрезмерном снижении АД имеется риск усиления ишемических нарушений, вплоть до развития острого инфаркта миокарда и инсульта);\u003Cbr\u003E- при почечной недостаточности (требуется контроль содержания калия и концентрации креатинина в крови), недавней трансплантации почки (отсутствие опыта клинического применения);\u003Cbr\u003E- при одновременном применении нестероидных противовоспалительных препаратов (НПВП), включая селективные ингибиторы циклооксигеназы-2 (ЦОГ-2) (повышение риска развития нарушений функции почек, включая возможность развития острой почечной недостаточности и увеличения содержания калия в сыворотке крови, особенно у пациентов пожилого возраста, пациентов с гиповолемией [включая пациентов, принимающих диуретики] или у пациентов с нарушением функции почек (см. раздел \"Взаимодействие с другими лекарственными средствами\");\u003Cbr\u003E- при применении в комбинации с ингибиторами АГ1Ф или алискиреном, так как по сравнению с монотерапией при двойной блокаде РААС имеется повышенный риск развития чрезмерного снижения АД. гиперкалиемии и нарушения функции почек (см. раздел \"Особые указания\");\u003Cbr\u003E- у пациентов с псориазом (в т.ч. в анамнезе) ввиду возможного обострения течения псориаза.\u003Cbr\u003EЧрезмерное снижение АД у пациентов с гиповолемией\u003Cbr\u003EПрименение препарата Апровель® до настоящего времени редко сопровождалось чрезмерным снижением АД у пациентов с артериальной гипертензией без сопутствующих заболеваний. Как и при применении ингибиторов АПФ, чрезмерное снижение АД, сопровождающееся клинической симптоматикой, может развиться у пациентов с гипонатриемией/гиповолемией (например, в результате интенсивной диуретической терапии, диареи или рвоты, соблюдения диеты с ограничением потребления поваренной соли), а также у пациентов, находящихся на гемодиализе. Перед началом применения препарата Апровель® необходимо скорректировать гиповолемию и/или гипонатриемию.\u003Cbr\u003EПациенты с функцией почек, зависящей от активности РААС\u003Cbr\u003EКак следствие ингибирования РААС можно ожидать ухудшения функции почек у предрасположенных у этому пациентов. У пациентов с функцией почек, зависящей от активности РААС (пациенты с артериальной гипертензией и стенозом почечной артерии одной или обеих почек, пациенты с хронической сердечной недостаточностью III и IV функционального класса [по классификации NYHA]), лечение лекарственными препаратами, которые воздействуют на РААС, ассоциировалось с олигурией и/или прогрессирующей азотемией и редко с острой почечной недостаточностью и/или смертью. Нельзя исключить возможность возникновения подобного эффекта при применении антагонистов рецепторов ангиотензина II, включая ирбесартан.\u003Cbr\u003EПочечная недостаточность и пересадка почки\u003Cbr\u003EПри применении препарата Апровель® у пациентов с почечной недостаточностью рекомендован периодический контроль содержания калия и концентрации креатинина в сыворотке крови. Нет клинических данных относительно применения препарата Апровель® у пациентов, недавно перенесших пересадку почки.\u003Cbr\u003EПациенты с артериальной гипертензией и сахарным диабетом 2 типа с нарушениями функции почек\u003Cbr\u003EБлагоприятное действие препарата Апровель® в отношении замедления прогрессирования почечных и сердечно-сосудистых нарушений имело разную степень выраженности у разных групп пациентов, менее выражено оно было у женщин и у пациентов, не относящихся к европеоидной расе.\u003Cbr\u003EВ клиническом исследовании IDNT у пациентов с артериальной гипертензией и сахарным диабетом 2 типа с протеинурией (≥ 900 мг/сутки), в подгруппе пациентов с высоким риском стеноза почечных артерий, ни у одного пациента, принимавшего препарат Апровель®, не наблюдалось острого раннего повышения концентрации креатинина в сыворотке крови, связанного со стенозом почечных артерий.\u003Cbr\u003EДвойная блокада РА АС при одновременном применении ирбесартана с ингибиторами АПФ или салискиреном\u003Cbr\u003EДвойная блокада РААС при применении комбинации ирбесартана с ингибиторами АПФ или алискиреном не рекомендуется, так как по сравнению с монотерапией имеется повышенный риск резкого снижения АД. развития гиперкалиемии и нарушения функции почек.\u003Cbr\u003EОдновременное применение ирбесартана с алискиреном или препаратами, содержащими алискирен, противопоказано у пациентов с сахарным диабетом и/или с умеренной или тяжелой почечной недостаточностью с СКФ \u003C 60 мл/мин/1,73 м2 площади поверхности тела (см. разделы \"Противопоказания\", \"Взаимодействие с другими лекарственными средствами\") и не рекомендуется у других пациентов.\u003Cbr\u003EОдновременное применение ирбесартана с ингибиторами АПФ противопоказано у пациентов с диабетической нефропатией (см. разделы \"Противопоказания\", \"Взаимодействие с другими лекарственными средствами\") и не рекомендуется у других пациентов.\u003Cbr\u003EПсориаз\u003Cbr\u003EУ пациентов с псориазом (в т.ч. в анамнезе) решение о применении препарата должно приниматься только после тщательной оценки соотношения риск/польза ввиду возможного обострения течения псориаза.\u003Cbr\u003EГиперкалиемия\u003Cbr\u003EКак и при применении других лекарственных препаратов, влияющих на РААС, при лечении препаратом Апровель® может развиваться гиперкалиемия, особенно при наличии почечной недостаточности и/или заболеваний сердца. У таких пациентов рекомендуется контролировать содержание калия в сыворотке крови.\u003Cbr\u003EСтеноз аортального или митрального клапана, гипертрофическая обструктивная кардиомиопатия\u003Cbr\u003EКак и при применении других вазодилататоров, при приеме препарата Апровель® пациентами с аортальным или митральным стенозом или с гипертрофической обструктивной кардиомиопатией необходимо соблюдать осторожность.\u003Cbr\u003EПервичный гиперальдостеронизм\u003Cbr\u003EПациенты с первичным гиперальдостеронизмом обычно не реагируют на гипотензивные препараты, действующие через ингибирование РААС. Поэтому применение препарата Апровель® в таких случаях нецелесообразно.\u003Cbr\u003EПациенты с ишемической болезнью сердца и/или клинически значимым атеросклерозом сосудов головного мозга\u003Cbr\u003EКак и при применении других гипотензивных препаратов, значительное снижение АД у пациентов с ишемической болезнью сердца и/или выраженным атеросклерозом сосудов головного мозга может привести к развитию инфаркта миокарда или инсульта. Лечение таких пациентов должно осуществляться под строгим контролем АД."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Исходя из данных исследований in vitro, не ожидается взаимодействия ирбесартана с лекарственными средствами, метаболизирующимися с помощью изоферментов CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2E1 или CYP3A4. Ирбесартан, в основном, метаболизируется с помощью изофермента CYP2C9 и, в меньшей степени, подвергается глюкуронированию. Не наблюдалось значительных фармакокинетических и фармакодинамических взаимодействий при совместном применении ирбесартана с варфарином. лекарственным средством, метаболизирующимся с помощью изофермента CYP2C9.\u003Cbr\u003EИрбесартан не изменяет фармакокинетику дигоксина и симвастатина.\u003Cbr\u003EПри совместном применении ирбесартана с гидрохлоротиазидом или нифедипином фармакокинетика ирбесартана не изменяется.\u003Cbr\u003EЛекарственные препараты, содержащие алискирен\u003Cbr\u003EОдновременное применение ирбесартана с лекарственными препаратами, содержащими алискирен. противопоказано у пациентов с сахарным диабетом или с умеренной и тяжелой почечной недостаточностью (СКФ \u003C 60 мл/мин/1,73 м2 площади поверхности тела) и не рекомендуется у других пациентов (см. разделы \"Противопоказания\", \"С осторожностью\", \"Особые указания\").\u003Cbr\u003EИнгибиторы АПФ\u003Cbr\u003EПрименение ирбесартана в сочетании с ингибиторами АПФ противопоказано у пациентов с диабетической нефропатией и не рекомендуется у других пациентов (см. разделы \"Противопоказания\", \"С осторожностью\", \"Особые указания\").\u003Cbr\u003EПрепараты калия и калийсберегающие диуретики, гепарин\u003Cbr\u003EНа основании опыта, полученного при применении других лекарственных средств, влияющих на РААС, при одновременном применении препаратов калия; заменителей соли, содержащих калий; калийсберегающих диуретиков или другими, способными повышать содержание калия в крови лекарственными средствами (гепарин), иногда может значительно повысить сывороточную концентрацию калия, что требует тщательного наблюдения за показателями калия плазмы крови у пациентов во время лечения.\u003Cbr\u003EНПВП, включая селективные ингибиторы циклооксигеназы-2 (ЦОГ-2)\u003Cbr\u003EПри одновременном применении антагонистов рецепторов ангиотензина II и НПВП (включая селективные ингибиторы ЦОГ-2) возможно ослабление антигипертензивного эффекта ирбесартана. У пациентов пожилого возраста, пациентов с гиповолемией или пациентов с нарушенной функцией почек применение НПВП. включая ингибиторы ЦОГ-2, одновременно с антагонистами рецепторов ангиотензина II, включая ирбесартан, может привести к ухудшению функции почек, включая возможное развитие острой почечной недостаточности. Эти эффекты обычно являются обратимыми. Следует периодически контролировать функцию почек у пациентов, одновременно принимающих ирбесартан и НПВП, включая ингибиторы ЦОГ-2.\u003Cbr\u003EПрепараты лития\u003Cbr\u003EСообщалось об увеличении сывороточных концентраций лития и увеличении его токсичности при одновременном применении солей лития и ирбесартана.\u003Cbr\u003EДиуретики и другие гипотензивные средства\u003Cbr\u003EПри одновременном применении ирбесартана и других гипотензивных средств возможно усиление антигипертензивного действия. Ирбесартан без каких-либо проблем применяли одновременно с другими гипотензивными средствами, такими как бета-адреноблокаторы, БМКК длительного действия и тиазидные диуретики.\u003Cbr\u003EПредшествующее лечение диуретиками в высоких дозах может приводить к гиповолемии и повышению риска чрезмерного снижения АД в начале лечения препаратом Апровель."},{"description":"","filters":[{"id":16435314,"name":"Регистрационный номер"}],"isMainProperty":false,"name":"Регистрационный номер","value":"ЛП-001260"},{"description":"","filters":[{"id":16435315,"name":"Дата государственной регистрации"}],"isMainProperty":false,"name":"Дата государственной регистрации","value":"01.12.2020"},{"description":"","filters":[{"id":34324371,"name":"Тип препарата"},{"id":7893318,"name":"Производитель"}],"isMainProperty":false,"name":"Владелец регистрационного 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или с высоким риском развития ИБС (другие клинические формы атеросклеротической болезни: атеросклероз периферических артерий, аневризма брюшной аорты и симптоматический атеросклероз сонной артерии; сахарный диабет; множественные факторы риска, которые соответствуют 10-летнему риску развития коронарных осложнений \u003E 20%);\u003Cbr\u003E- с целью снижения концентрации ТГ у пациентов с тяжелой гиперглицеридемией (дислипидемия IV, V тип по Фредриксону);\u003Cbr\u003E- с целью снижения повышенной концентрации ЛПНП, общего холестерина, триглицеридов и АпоВ (аполипопротеин В) и повышения концентрации ЛПВП у пациентов с первичной гиперлипидемией или смешанной дислипидемией (тип IIа, IIb, III, IV по Фредриксону)."},{"description":"","filters":[{"id":15768002,"name":"Противопоказания"}],"isMainProperty":false,"name":"Противопоказания","value":"Препарат строго противопоказан в следующих случаях:\u003Cbr\u003E- повышенная чувствительность к фенофибрату или другим компонентам лекарственного средства,\u003Cbr\u003E- печеночная недостаточность (включая билиарный цирроз и персистирующее нарушение функции печени неясной этиологии),\u003Cbr\u003E- тяжелая почечная недостаточность (клиренс креатинина \u003C 20 мл/мин),\u003Cbr\u003E- возраст до 18 лет (эффективность и безопасность не установлены),\u003Cbr\u003E- наличие в анамнезе фотосенсибилизации или фототоксичности при лечении фибратами или кетопрофеном,\u003Cbr\u003E- заболевания желчного пузыря в анамнезе,\u003Cbr\u003E- период грудного вскармливания,\u003Cbr\u003E- хронический или острый панкреатит, за исключением случаев острого панкреатита, обусловленного выраженной гипертриглицеридемией."},{"description":"","filters":[{"id":15768292,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит:\u003Cbr\u003Eактивное вещество: фенофибрат 145 мг;\u003Cbr\u003Eвспомогательные вещества: крахмал кукурузный 137 мг, кремния диоксид коллоидный 10 мг, кроскармеллоза натрия 33 мг, маннитол 170 мг, магния стеарат 6 мг, повидон К-30 44 мг, целлюлоза микрокристаллическая 105 мг;\u003Cbr\u003Eпленочная оболочка: Опадрай II белый 20 мг, в том числе: поливиниловый спирт 9,38 мг, макрогол (полиэтиленгликоль 4000) 4,72 мг, тальк 3,48 мг, титана диоксид 2,42 мг."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Фенофибрат"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Таблетки следует проглатывать целиком, не разжевывая, одновременно с приемом пищи.\u003Cbr\u003EВзрослые. По одной таблетке один раз в сутки. Пациенты, принимающие по одной капсуле фенофибрата 200 мг, могут перейти на прием одной таблетки препарата Фенофибрат Канон 145 мг без дополнительной корректировки дозы. Максимальная суточная доза 145 мг.\u003Cbr\u003EПожилые пациенты. Рекомендуется принимать 1 таблетку по 145 мг для взрослых (по одной таблетке один раз в сутки).\u003Cbr\u003EПациенты с заболеваниями печени. Применение препарата у пациентов с заболеваниями печени не изучено.\u003Cbr\u003EПрепарат следует принимать длительное время, одновременно продолжая соблюдать диету, которой пациент придерживался до начала лечения препаратом Фенофибрат Канон."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Побочные эффекты для терапевтических доз приведены с распределением по частоте и системно-органным классам согласно классификации ВОЗ.\u003Cbr\u003EСо стороны пищеварительной системы:\u003Cbr\u003Eчасто - боль в животе, тошнота, рвота, диарея и метеоризм умеренной тяжести;\u003Cbr\u003Eнечасто - случаи панкреатита.\u003Cbr\u003EСо стороны печени:\u003Cbr\u003Eчасто - умеренное повышение концентрации сывороточных трансаминаз; нечасто - образование желчных камней;\u003Cbr\u003Eочень редко - гепатит. При появлении симптомов гепатита (желтуха, кожный зуд) следует провести лабораторные исследования и, в случае подтверждения гепатита, отменить фенофибрат. (см. раздел \"Особые указания\").\u003Cbr\u003EСо стороны скелетно-мышечной системы и соединительной ткани:\u003Cbr\u003Eредко - диффузная миалгия, миозит, спазм мышц и слабость;\u003Cbr\u003Eочень редко - рабдомиолиз, повышение активности креатинфосфокиназы (КФК).\u003Cbr\u003EСосудистые нарушения:\u003Cbr\u003Eнечасто - венозная тромбоэмболия (легочная эмболия, тромбоз глубоких вен).\u003Cbr\u003EСо стороны кровеносной и лимфатической системы:\u003Cbr\u003Eредко - повышение гемоглобина и лейкоцитов.\u003Cbr\u003EСо стороны нервной системы:\u003Cbr\u003Eредко - сексуальная дисфункция, головная боль.\u003Cbr\u003EСо стороны органов дыхания:\u003Cbr\u003Eочень редко - интерстициальные пневмопатии.\u003Cbr\u003EСо стороны колеи и подкожно-жировой клетчатки:\u003Cbr\u003Eнечасто - сыпь, кожный зуд, крапивница или реакции светочувствительности;\u003Cbr\u003Eредко - алопеция;\u003Cbr\u003Eочень редко - фотосенсибилизация, сопровождающаяся эритемой, образованием волдырей или узелков на участках кожи, подвергнутых воздействию солнечного света или искусственного УФ-освещения (например, кварцевой лампы) в отдельных случаях (даже после многомесячного применения без каких-либо осложнений).\u003Cbr\u003EЛабораторные исследования:\u003Cbr\u003Eнечасто - повышение концентрации креатинина и мочевины в сыворотке крови."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Активируя РАПП-альфа (альфа-рецепторы, активируемые пролифератором пероксисом), фенофибрат усиливает липолиз и выведение из плазмы крови атерогенных липопротеинов с высоким содержанием триглицеридов путем активации липопротеинлипазы и уменьшения синтеза апопротеинов СIII. Активация РАПП-альфа также приводит к усилению синтеза апопротеинов AI и АII.\u003Cbr\u003EФенофибрат является производным фиброевой кислоты, способность которой изменять содержание липидов в организме человека, опосредована активацией РАПП-альфа. Описанные выше эффекты фенофибрата на липопротеины приводят к уменьшению содержания фракции липопротеинов низкой (ЛПНП) и очень низкой плотности (ЛПОНП), к числу которых относится апопротеин В, и увеличению содержания фракции липопротеинов высокой плотности (ЛПВП), к числу которых относятся апопротеины AI и АII.\u003Cbr\u003EКроме того, за счет коррекции нарушений синтеза и катаболизма ЛПОНП, фенофибрат повышает клиренс ЛПНП и снижает содержание плотных и небольшого размера частиц ЛПНП, повышение которых наблюдается у пациентов с атерогенным фенотипом липидов, частым нарушением у пациентов с риском ишемической болезни сердца. В ходе клинических исследований было отмечено, что применение фенофибрата снижает концентрацию общего холестерина на 20 - 25% и триглицеридов на 40-55% при повышении концентрации ЛПВП-холестерина на 10-30%. У пациентов с гиперхолестеринемией, у которых концентрация ЛПНП-холестерина снижается на 20-35% использование фенофибрата приводило к снижению соотношений: \"общий холестерин/ЛПВП-холестерин\", \"ЛПНП- холестерин/ЛПВП-холестерин\" и \"А по В/A по АI\", являющихся маркерами атерогенного риска.\u003Cbr\u003EУчитывая значимый эффект на концентрацию ЛПНП-холестерина и триглицеридов, применение препарата фенофибрата эффективно у пациентов с гиперхолестеринемией, как сопровождающейся, так и не сопровождающейся гипертриглицеридемией, включая вторичную гиперлипопротеинемию, например при сахарном диабете 2-го типа. Во время лечения фенофибратом могут значительно уменьшиться и даже полностью исчезнуть внесосудистые отложения холестерина (сухожильные и туберозные ксантомы). У пациентов с повышенным уровнем фибриногена, получивших лечение фенофибратом, отмечено значительное снижение данного показателя, так же как и у пациентов с повышенным уровнем липопротеинов. Другие маркеры воспаления, такие как С-реактивный белок, также уменьшаются при лечении фенофибратом.\u003Cbr\u003EДля пациентов с дислипидемией и гиперурикемией дополнительное преимущество заключается в урикозурическом эффекте фенофибрата, приводящем к снижению концентрации мочевой кислоты приблизительно на 25%.\u003Cbr\u003EВ ходе клинического исследования и в экспериментах на животных было показано, что фенофибрат снижает агрегацию тромбоцитов, вызванную аденозиндифосфатом, арахидоновой кислотой и эпинефрином."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"гиполипидемические средства"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"В сухом, защищенном от света месте при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Случаи передозировки не описаны. Специфичный антидот неизвестен. При подозрении на передозировку следует назначить симптоматическое и, при необходимости, поддерживающее лечение.Гемодиализ неэффективен."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Фертильность\nКлинические данные по влиянию препарата на фертильность у мужчин или женщин отсутствуют, однако исследования на животных продемонстрировали обратимое действие фенофибрата на фертильность.\u003Cbr\u003EБеременность\nОтсутствуют достаточные данные о применении фенофибрата беременными. В экспериментах на животных тератогенный эффект фенофибрата не наблюдался. Эмбриотоксичность отмечалась при назначении в ходе доклинических испытаний доз, токсичных для материнского организма. Потенциальный риск для человека неизвестен. Поэтому применять препарат во время беременности можно только после тщательной оценки соотношения ожидаемой пользы к возможному риску.\u003Cbr\u003EПериод грудного вскармливания\nНедостаточно информации об экскреции фенофибрата и/или его метаболитов в грудное молоко. Нельзя исключить риск для грудных детей. Не следует применять препарат во время грудного вскармливания. При необходимости применения препарата в период лактации грудное вскармливание необходимо прекратить."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"При применении препарата не было отмечено влияния на способность к управлению автомобилем и другими механизмами."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Перед тем как приступить к лечению препаратом Фенофибрат Канон, следует провести соответствующее лечение для устранения причины вторичной гиперхолестеринемии, например, при таких заболеваниях, как неконтролируемый сахарный диабет 2 типа, гипотиреоз, нефротический синдром, диспротеинемия, обструктивные заболевания печени, последствия медикаментозной терапии, алкоголизм.\u003Cbr\u003EЭффективность терапии следует оценивать по содержанию липидов (общего холестерина, ЛПНП, триглицеридов) в сыворотке крови. При отсутствии терапевтического эффекта после нескольких месяцев терапии (как правило, после 3-х месяцев) следует рассмотреть целесообразность назначения сопутствующей или альтернативной терапии.\u003Cbr\u003EУ пациентов с гиперлипидемией, принимающих эстрогены или гормональные контрацептивы, содержащие эстрогены, необходимо выяснить, имеет ли гиперлипидемия первичную или вторичную природу. В таких случаях повышение уровня липидов может быть вызвано приемом эстрогенов.\u003Cbr\u003EФункция печени: при приеме фенофибрата и других препаратов, снижающих концентрации липидов, у некоторых пациентов описано повышение активности \"печеночных\" трансаминаз. В большинстве случаев такое повышение было временным, незначительным и бессимптомным. В течение первых 12 месяцев лечения рекомендуется контролировать активность трансаминаз (аланинаминотрансферазы (АЛТ), аспартатаминотрансферазы (ACT)) через каждые 3 месяца. Пациенты, у которых на фоне лечения повысились концентрации трансаминаз, требуют внимания, и в случае повышения концентрации АЛТ и ACT более чем в 3 раза по сравнению с верхней границей нормы прием препарата прекращают.\u003Cbr\u003EПанкреатит: были описаны случаи развития панкреатита в период лечения фенофибратом. Возможными причинами панкреатита в этих случаях были: недостаточная эффективность препарата у пациентов с тяжелой гипертриглицеридемией, прямое воздействие препарата, а также вторичные явления, связанные с наличием камней или образованием осадка в желчном пузыре, сопровождающихся непроходимостью общего желчного протока.\u003Cbr\u003EМышцы: при приеме фенофибрата и других лекарственных препаратов, снижающих концентрации липидов, описаны случаи токсического влияния на мышечную ткань, включая очень редкие случаи рабдомиолиза. Частота такого нарушения повышается в случае гипоальбуминемии и почечной недостаточности в анамнезе. Возможность возникновения данного осложнения увеличивается в случаях гипоальбуминемии и почечной недостаточности.\u003Cbr\u003EТоксическое влияние на мышечную ткань может быть заподозрено на основании жалоб пациента на слабость, диффузную миалгию, миозит, мышечные спазмы и судороги и/или выраженного повышения активности креатининфосфокиназы (КФК) (более чем в 5 раз по сравнению с верхней границей нормы). В этих случаях лечение фенофибратом необходимо прекратить.\u003Cbr\u003EРиск развития рабдомиолиза может повышаться у пациентов с предрасположенностью к миопатии и/или рабдомиолизу, включая возраст старше 70 лет, отягощенный анамнез по наследственным мышечным заболеваниям, нарушение функции почек, гипотиреоз, злоупотребление алкоголем. Таким пациентам следует назначать препарат только в том случае, если ожидаемая польза превышает возможный риск развития рабдомиолиза. При приеме препарата Фенофибрат Канон одновременно с ингибиторами ГМГ-КоА-редуктазы или другими фибратами повышается риск серьезного токсического воздействия на мышечные волокна, особенно если пациент до начала лечения страдал заболеванием мышц. В связи с этим совместное назначение препарата Фенофибрат Канон и статина допустимо только при наличии у пациента тяжелой смешанной дислипидемии и высокого сердечно-сосудистого риска, при отсутствии заболевания мышц в анамнезе и в условиях пристального контроля, направленного на выявление признаков развития токсического влияния на мышечную ткань.\u003Cbr\u003EПочечная функция: При применении препарата Фенофибрат Канон в качестве монотерапии или в сочетании со статинами, у пациентов было отмечено обратимое повышение концентрации креатинина в сыворотке крови. Повышение концентрации креатинина, в целом, было стабильным в течение времени без признаков дальнейшего увеличения концентрации креатинина в сыворотке крови при длительной терапии, с тенденцией к возврату к начальным значениям после отмены лечения. Клиническое значение данных наблюдений не установлено. У пациентов с почечной недостаточностью при приеме препарата Фенофибрат Канон рекомендуется проводить контроль почечной функции. Контроль почечной функции необходимо проводить пациентам с риском развития почечной недостаточности, а именно пациентам пожилого возраста и пациентам с сахарным диабетом. Лечение должно быть отменено в случае увеличения концентрации креатинина \u003E50% от верхней границы нормы. Рекомендуется определять концентрацию креатинина на протяжении первых 3 месяцев после начала лечения, а также периодически после его окончания.\u003Cbr\u003EС осторожностью:\u003Cbr\u003E- При гипотиреозе;\u003Cbr\u003E- пациентам, злоупотребляющим алкоголем;\u003Cbr\u003E- пациентам, с нарушением функции почек (КК более 20 мл/мин);\u003Cbr\u003E- пожилого возраста, с отягощенным анамнезом по наследственным мышечным заболеваниям;\u003Cbr\u003E- при одновременном приеме пероральных антикоагулянтов, ингибиторов ГМГ-КоА-редуктазы (см. раздел \"Взаимодействие с другими лекарственными средствами\")."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Пероральные антикоагулянты\u003Cbr\u003EФенофибрат усиливает эффект пероральных антикоагулянтов и может повысить риск кровотечений, что связано с вытеснением антикоагулянта из мест связывания с белками плазмы крови.\u003Cbr\u003EВ начале лечения фенофибратом рекомендуется снизить дозу антикоагулянтов приблизительно на треть с последующим постепенным подбором дозы. Подбор дозы рекомендуется проводить под контролем уровня МНО (международного нормализованного отношения).\u003Cbr\u003EЦиклоспорин\u003Cbr\u003EОписано несколько тяжелых случаев обратимого снижения почечной функции во время одновременного лечения фенофибратом и циклоспорином. Поэтому необходимо контролировать состояние почечной функции у таких пациентов и отменить фенофибрат в случае серьезного изменения лабораторных показателей.\u003Cbr\u003EИнгибиторы ГМГ-КоА-редуктазы (статины) и другие фибраты\u003Cbr\u003EПри приеме фенофибрата одновременно с ингибиторами ГМГ-КоА- редуктазы или другими фибратами повышается риск серьезного токсического воздействия на мышечные волокна (см. раздел \"Особые указания\").\u003Cbr\u003EИзоферменты системы цитохрома Р450\u003Cbr\u003EИсследования микросом из печени человека in vitro показали, что фенофибрат и фенофиброевая кислота не являются ингибиторами следующих изоферментов цитохрома Р450 (CYP3A4, CYP2D6, CYP2E1 или CYP1A2). 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