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7 достижений
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На пальце образовалось покраснение. Дерматолог поставил диагноз: "локальный дерматит". Прописал эту мазь. После двух недель применения дерматит прошел. Рекомендую
Официальный представитель компании Palmolive в России
Добрый день! Благодарим Вас за отзыв! Мы всегда стараемся удовлетворить потребность каждого нашего покупателя. Строго следим за качеством производимой продукции. Признательны вам за отзывчивость в нашу сторону! Приятного пользования!
Добрый день! Благодарим Вас за отзыв! Мы всегда стараемся удовлетворить потребность каждого нашего покупателя. Строго следим за качеством производимой продукции. Признательны вам за отзывчивость в нашу сторону! Приятного пользования!
Принимаю два раза в день по половине стакана за 30 минут до еды. Чтобы не разрушать зубную эмаль пью через трубочку. Помогает при мочекаменной болезни. Заваривать можно в термосе или термокружке. Готовый раствор хранить в холодильнике
Цена не превышает 1000 руб/100шт, надёжный производитель
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Дважды в год пропиваю месячный курс препарата (30 капсул). Благодаря этому размер ДГПЖ не увеличивается. Важно при простатите избежать оперативного вмешательства и профлосин хороший помощник. Лично у меня побочки не вызывает, за исключением иногда проявляющейся крапивицы. Главное, хорошо утром позавтракать и минут через десять проглотить капсулу, обильно запивая водой. Всем, кому за 50, придется познакомится с препаратами подобного рода.
Перепробовал бисопролол разных производителей. Подошёл именно этот и с дозировкой определился. Стоит не дорого, в наличии во всех аптеках. Отлично снижает ЧСС, нормализует давление. Препарат длительного действия. Одной таблетки хватает на 24часа.
Суппозитории упакованы в очень жёсткую пленку. Руками не вскрыть. После вскрытия ножницами свечи крошатся в руках. По этой причине использовать их по назначению практически не возможно. А стоят они не дёшево. Лучше переплатить и купить препарат проверенного производителя
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дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция; кардиогенный шок; коллапс; острая сердечная недостаточность; хроническая сердечная недостаточность в стадии декомпенсации, требующая проведения инотропной терапии; атриовентрикулярная блокада II и III степени, без электрокардиостимулятора; синоатриальная блокада; синдром слабости синусового узла; выраженная брадикардия (ЧСС менее 50 уд/мин); тяжелые формы бронхиальной астмы или хронической обструктивной болезни легких; выраженное снижение артериального давления (систолическое АД менее 90 мм рт.ст); выраженные, нарушения периферического кровообращения или синдром Рейно; феохромоцитома (без одновременного применения альфа-адреноблокаторов); метаболический ацидоз; период лактации; одновременный прием ингибиторов моноаминоксидазы (МАО) (за исключением ингибиторов МАО(-)В); одновременное применение с флоктафенином и сультопридом; возраст до 18 лет (эффективность и безопасность не установлены)."},{"description":"","filters":[{"id":15768292,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"1 таблетка, покрытая пленочной оболочкой, содержит: \u003Cbr\u003Eдействующее вещество: бисопролола фумарат 2,50 мг;\u003Cbr\u003Eвспомогательные вещества: крахмал картофельный 18,00 мг, кремния диоксид коллоидный 1,50 мг, лактозы моногидрат 54,00 мг, магния стеарат 1,00 мг, повидон К-30 3,00 мг, целлюлоза микрокристаллическая 20,00 мг; 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целлюлоза микрокристаллическая 32 мг;\u003Cbr\u003Eсостав пленочной оболочки: селекоат AQ-02140 9 мг, в том числе: гипромеллоза (гидроксипропилметилцеллюлоза) 4,95 мг, краситель солнечный закат желтый 0,063 мг, макрогол-400 (полиэтилен гликоль 400) 0,81 мг, макрогол-6000 (полиэтиленгликоль 6000) 1,26 мг; титана диоксид 1,917 мг.\u003Cbr\u003E"},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Бисопролол"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Препарат Бисопролол Канон принимают внутрь, утром натощак, 1 раз в сутки с достаточным количеством жидкости, утром до завтрака, во время или после него. Таблетки не следует разжевывать или растирать в порошок.\u003Cbr\u003EХроническая сердечная недостаточность\u003Cbr\u003EНачало лечения ХСН препаратом Бисопролол Канон требует обязательного проведения специальной фазы титрования и регулярного врачебного контроля. \u003Cbr\u003EПредварительным условием для лечения препаратом Бисопролол Канон является стабильная хроническая сердечная недостаточность без признаков обострения.\u003Cbr\u003EЛечение ХСН препаратом Бисопролол Канон начинается в соответствии со следующей схемой титрования. При этом может потребоваться индивидуальная адаптация в зависимости от того, насколько хорошо пациент переносит назначенную дозу, т.е. дозу можно увеличивать только в том случае, если предыдущая доза хорошо переносилась. \u003Cbr\u003EДля обеспечения соответствующего процесса титрования на начальных стадиях лечения рекомендуется применять препарат в меньших дозах. Рекомендуемая начальная доза составляет 1,25 мг (1/2 таблетки по 2,5 мг) один раз в сутки. В зависимости от индивидуальной переносимости дозу следует постепенно повышать до 2,5 мг, 3,75 мг (11/2 таблетки по 2,5 мг), 5 мг, 7,5 мг (1 таблетка по 5 мг и 1/2 таблетки по 2,5 мг) и 10 мг 1 раз в день с интервалом не менее 2-х или более недель.\u003Cbr\u003EЕсли увеличение дозы препарата плохо переносится пациентом, возможно снижение дозы.\u003Cbr\u003EМаксимальная суточная доза при лечении ХСН составляет 10 мг 1 раз в день.\u003Cbr\u003EВо время титрования рекомендуется регулярный контроль АД, ЧСС и симптомов нарастания выраженности ХСН. Усугубление симптомов ХСН возможно уже с первого дня применения препарата.\u003Cbr\u003EВо время фазы титрования или после нее может возникнуть временное ухудшение течения ХСН, артериальная гипотензия или брадикардия. В этом случае рекомендуется, прежде всего, провести коррекцию дозы препаратов сопутствующей терапии. Также может потребоваться временное снижение дозы препарата Бисопролол Канон или отмена лечения.\u003Cbr\u003EПосле стабилизации состояния пациента следует провести повторное титрование дозы, либо продолжить лечение.\u003Cbr\u003EАртериальная гипертензия и ишемическая болезнь сердца (профилактика приступов стабильной стенокардии)\u003Cbr\u003EПри артериальной гипертензии и ишемической болезни сердца препарат назначают по 5 мг 1 раз в сутки. При необходимости дозу увеличивают до 10 мг 1 раз в сутки.\u003Cbr\u003EПри лечении артериальной гипертензии и стенокардии максимальная суточная доза составляет 20 мг 1 раз/сут.\u003Cbr\u003EВозможно применение препарата бисопролола в другой лекарственной форме (таблетки по 2,5 мг с риской).\u003Cbr\u003EВо всех случаях режим приема и дозу подбирает врач каждому пациенту индивидуально, в частности, учитывая индивидуальные особенности и состояние пациента.\u003Cbr\u003EОсобые группы пациентов\u003Cbr\u003EНарушение функции почек или печени:\u003Cbr\u003EПри нарушении функции печени или почек легкой или умеренной степени обычно не требует коррекции дозы.\u003Cbr\u003EПри выраженных нарушениях функции почек (клиренс креатинина менее 20 мл/мин) и у пациентов с тяжелыми заболеваниями печени максимальная суточная доза составляет 10 мг. Увеличение дозы у таких больных должно осуществляться с особой осторожностью.\u003Cbr\u003EПожилые пациенты:\u003Cbr\u003EКоррекции дозы не требуется.\u003Cbr\u003EК настоящему времени недостаточно данных относительно применения препарата Бисопролол Канон у пациентов с ХСН, сопряженной с сахарным диабетом 1 типа, выраженными нарушениями функции почек и/или печени, рестриктивной кардиомиопатией, врожденными пороками сердца или гемодинамически обусловленным пороком сердца.\u003Cbr\u003EТакже до сих пор не было получено достаточных данных относительно пациентов с ХСН с инфарктом миокарда в течение последних 3 месяцев.\u003Cbr\u003E"},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Частота побочных реакций, приведенных ниже, определялась соответственно следующему:\u003Cbr\u003E- очень часто ≥ 1/10;\u003Cbr\u003E- часто ≥ 1/100, \u003C1/10;\u003Cbr\u003E- нечасто ≥1/1000, \u003C1/100;\u003Cbr\u003E- редко ≥ 1/10 000, \u003C1/1000;\u003Cbr\u003E- очень редко \u003C 1/10 000, включая отдельные сообщения.\u003Cbr\u003EСо стороны центральной нервной системы\u003Cbr\u003EЧасто: головокружение*, головная боль*.\u003Cbr\u003EРедко: потеря сознания.\u003Cbr\u003EОбщие нарушения\u003Cbr\u003EЧасто: астения (у пациентов с ХСН), повышенная утомляемость*.\u003Cbr\u003EНечасто: астения (у пациентов с артериальной гипертензией или стенокардией).\u003Cbr\u003EПсихические нарушения \u003Cbr\u003EНечасто: депрессия, бессонница.\u003Cbr\u003EРедко: галлюцинации, ночные кошмары.\u003Cbr\u003EСо стороны нервной системы\u003Cbr\u003EНечасто: повышенная утомляемость, астения, головокружение, головная боль.\u003Cbr\u003EРедко: потеря сознания. \u003Cbr\u003EСо стороны кожных покровов\u003Cbr\u003EРедко: реакции повышенной чувствительности, такие как кожный зуд, сыпь, гиперемия кожных покровов.\u003Cbr\u003EОчень редко: алопеция. Бета-адреноблокаторы могут способствовать обострению симптомов течения псориаза или вызывать псориазоподобную сыпь.\u003Cbr\u003EСо стороны мочеполовой системы\u003Cbr\u003EРедко: нарушение потенции, ослабление либидо, болезнь Пейрони, цистит, почечная колика, полиурия.\u003Cbr\u003EСо стороны опорно-двигательного аппарата\u003Cbr\u003EНечасто: мышечная слабость, судороги мышц.\u003Cbr\u003EСо стороны пищеварительной системы\u003Cbr\u003EЧасто: тошнота, рвота, диарея, запор.\u003Cbr\u003EРедко: гепатит.\u003Cbr\u003EСо стороны органов кроветворения \u003Cbr\u003EВ отдельных случаях - тромбоцитопения, агранулоцитоз.\u003Cbr\u003EСо стороны дыхательной системы\u003Cbr\u003EНечасто: бронхоспазм у пациентов с бронхиальной астмой или обструкцией дыхательных путей в анамнезе.\u003Cbr\u003EРедко: аллергический ринит.\u003Cbr\u003EСо стороны органов чувств\u003Cbr\u003EРедко: уменьшение слезотечения (следует учитывать при ношении контактных линз). \u003Cbr\u003EОчень редко: конъюнктивит.\u003Cbr\u003EСо стороны органа слуха \u003Cbr\u003EРедко: нарушения слуха.\u003Cbr\u003EСо стороны сердечно-сосудистой системы\u003Cbr\u003EОчень часто: брадикардия (у пациентов с ХСН).\u003Cbr\u003EЧасто: усугубление симптомов течения ХСН (у пациентов с ХСН), ощущение похолодания и онемения в конечностях, выраженное снижение АД, особенно у пациентов с ХСН.\u003Cbr\u003EНечасто: нарушение AV проводимости; брадикардия (у пациентов с артериальной гипертензией или стенокардией); усугубление симптомов течения ХСН (у пациентов с артериальной гипертензией или стенокардией), ортостатическая гипотензия.\u003Cbr\u003EВлияние на плод\u003Cbr\u003EВнутриутробная задержка роста, гипогликемия, брадикардия.\u003Cbr\u003EСо стороны репродуктивной системы \u003Cbr\u003EРедко: нарушение потенции.\u003Cbr\u003EЛабораторные показатели\u003Cbr\u003EРедко: повышение концентрации триглицеридов и активности \"печеночных\" трансаминаз в крови (аспартатаминотрансферазы (ACT), аланинаминотрансферазы (АЛТ)).\u003Cbr\u003E* У пациентов с артериальной гипертензией или стенокардией данные симптомы появляются обычно в начале курса лечения, не ярко выражены и проходят в течение 1-2 недель после начала лечения.\u003Cbr\u003E"},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Селективный бета1-адреноблокатор, без собственной симпатомиметической активности, не обладает мембраностабилизирующим действием. Обладает лишь незначительным сродством к бета2-адренорецепторам гладкой мускулатуры бронхов и сосудов, а также к бета2-адренорецепторам, участвующим в регуляции метаболизма. Следовательно, бисопролол в целом не влияет на сопротивление дыхательных путей и метаболические процессы, в которые вовлечены бета2-адренорецецепторы.\u003Cbr\u003EКак правило, максимальное снижение артериального давления (АД) достигается через 2 недели после начала терапии.\u003Cbr\u003EБисопролол снижает активность симпатоадреналовой системы, блокируя бета1-адренорецепторы сердца.\u003Cbr\u003EПри однократном приеме внутрь у пациентов с ишемической болезнью сердца без признаков хронической сердечной недостаточности (ХСН) бисопролол урежает частоту сердечных сокращений (ЧСС), уменьшает ударный объем крови и, как следствие, уменьшает фракцию выброса и потребность миокарда в кислороде. При длительной терапии изначально повышенное общее периферическое сосудистое сопротивление (ОПСС) снижается. Снижение активности ренина в плазме крови рассматривается как один из компонентов антигипертензивного действия бета-адреноблокаторов."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"бета1-адреноблокатор селективный"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"При температуре не выше 25 °С, в упаковке производителя. Хранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Симптомы\u003Cbr\u003EНаиболее частые симптомы передозировки: AV блокада, брадикардия, снижение АД, бронхоспазм, острая сердечная недостаточность и гипогликемия.\u003Cbr\u003EЛечение\u003Cbr\u003EПри возникновении передозировки прежде всего необходимо прекратить приём препарата и начать поддерживающую симптоматическую терапию. \u003Cbr\u003EПри выраженной брадикардии: внутривенное введение атропина. Если эффект недостаточный, с осторожностью можно ввести средство, обладающее положительным хронотропным действием. Иногда может потребоваться временная постановка искусственного водителя ритма.\u003Cbr\u003EПри выраженном снижении АД: внутривенное введение плазмозамещающих растворов и назначение вазопрессоров.\u003Cbr\u003EПри AV блокаде: пациенты должны находиться под постоянным наблюдением и получать лечение бета-адреномиметиками, такими как эпинефрин. В случае необходимости - постановка искусственного водителя ритма. \u003Cbr\u003EПри обострении течения ХСН: внутривенное введение диуретиков, препаратов с положительным инотропным эффектом, а также вазодилататоров.\u003Cbr\u003EПри бронхоспазме: применение бронходилататоров, в том числе бета2-симпатомиметиков и/или аминофиллина.\u003Cbr\u003EПри гипогликемии: внутривенное введение декстрозы (глюкозы).\u003Cbr\u003E"},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Во время беременности препарат Бисопролол Канон следует рекомендовать к применению только в том случае, если польза для матери превышает риск развития побочных эффектов у плода. Как правило, бета-адреноблокаторы снижают кровоток в плаценте и могут повлиять на развитие плода. Следует отслеживать кровоток в плаценте и матке, а также наблюдать за ростом и развитием будущего ребенка, в случае появления нежелательных явлений в отношений беременности и/или плода - принимать альтернативные методы терапии. Следует тщательно обследовать новорожденного после родов. В первые три дня жизни могут возникать симптомы гипогликемии и брадикардии.\u003Cbr\u003EДанных о выделении бисопролола в грудное молоко нет. Поэтому прием препарата Бисопролол Канон не рекомендуется женщинам в период кормления грудью. Если необходим прием препарата Бисопролол Канон в период лактации, грудное вскармливание следует прекратить."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Не прерывайте лечение препаратом резко и не меняйте рекомендованную дозу без предварительной консультации с врачом, так как это может привести к временному ухудшению деятельности сердца. Лечение не следует прерывать внезапно, особенно у пациентов с ишемической болезнью сердца. Если прекращение лечения необходимо, то дозу следует снижать постепенно.\u003Cbr\u003EКонтроль за больными, принимающими бисопролол, должен включать наблюдение за ЧСС и АД (в начале лечения - ежедневно, затем 1 раз в 3-4 мес), ЭКГ, концентрацией глюкозы крови у больных сахарным диабетом (1 раз в 4-5 мес). У пожилых пациентов рекомендуется следить за функцией почек (1 раз в 4-5 мес). Следует обучить больного методике подсчета ЧСС и проинструктировать о необходимости врачебной консультации при ЧСС менее 50 уд/мин.\u003Cbr\u003EПеред началом лечения рекомендуется проводить исследование функции внешнего дыхания у больных с отягощенным бронхолегочным анамнезом.\u003Cbr\u003EПримерно у 20% больных стенокардией бета-адреноблокаторы неэффективны. Основные причины - тяжелый коронарный атеросклероз с низким порогом ишемии (ЧСС менее 100 уд/мин) и повышенный конечный диастолический объем левого желудочка, нарушающий субэндокардиальный кровоток.\u003Cbr\u003EУ \"курильщиков\" эффективность бета-адреноблокаторов ниже.\u003Cbr\u003EБольные, пользующиеся контактными, линзами, должны учитывать, что на фоне лечения возможно уменьшение продукции слёзной жидкости.\u003Cbr\u003EПри применении у больных с феохромоцитомой имеется риск развития парадоксальной артериальной гипертензии (если предварительно не достигнута эффективная альфа-адреноблокада).\u003Cbr\u003EПри гипертиреозе препарат может маскировать определенные клинические признаки гиперфункции щитовидной железы (гипертиреоза), например, тахикардию. Резкая отмена препарата у больных с гипертиреозом противопоказана, поскольку способна усилить симптоматику.\u003Cbr\u003EПри сахарном диабете может замаскировать тахикардию, вызванную гипогликемией. В отличие от неселективных бета-адреноблокаторов, практически не усиливает вызванную инсулином гипогликемию и не задерживает восстановление содержания глюкозы в крови до нормального уровня.\u003Cbr\u003EПри одновременном приеме клонидина его прием может быть прекращен только через несколько дней после отмены препарата Бисопролол Канон. Возможно усиление выраженности реакций повышенной чувствительности и отсутствие эффекта от обычных доз эпинефрина (адреналина) на фоне отягощенного аллергологического анамнеза.\u003Cbr\u003EВ случае необходимости проведения планового хирургического лечения отмену препарата проводят за 48 ч до проведения общей анестезии. Если больной принял препарат перед хирургическим вмешательством, ему следует подобрать лекарственное средство для общей анестезии с минимальным отрицательным инотропным действием. Следует предупредить врача-анестезиолога о том, что Вы принимаете препарат Бисопролол Канон. \u003Cbr\u003EРеципрокную активацию блуждающего нерва можно устранить внутривенным введением атропина (1-2 мг).\u003Cbr\u003EЛекарственные средства, снижающие запасы катехоламинов (в том числе резерпин), могут усилить действие бета-адреноблокаторов, поэтом) больные, принимающие такие сочетания лекарственных средств, должны находиться под постоянным наблюдением врача на предмет выявления артериальной гипотензии или брадикардии. Больным с бронхоспастическими заболеваниями можно назначать кардиоселективные адреноблокаторы в случае непереносимости и/или неэффективности других гипотензивных средств, но при этом следует строго следить за дозировкой. Передозировка опасна развитием бронхоспазма.\u003Cbr\u003EВ случае появления у больных пожилого возраста нарастающей брадикардии (менее 50 у д/мин), артериальной гипотензии (систолическое АД ниже 100 мм рт.ст.), атриовентрикулярной блокады, бронхоспазма, желудочковых аритмий, тяжелых нарушений функции печени и почек необходимо уменьшить дозу или прекратить лечение. Рекомендуется прекращать терапию при развитии депрессии, вызванной приемом бета-адреноблокаторов.\u003Cbr\u003EНельзя резко прерывать лечение из-за опасности развития тяжелых аритмий и инфаркта миокарда. Отмену проводят постепенно, снижая дозу в течение 2 недель и более (снижают дозу на 25% в 3-4 дня).\u003Cbr\u003EСледует отменять перед исследованием содержания в крови и моче катехоламинов, норметанефрина и ванилин миндальной кислоты; титров антинуклеарных антител.\u003Cbr\u003E\u003Cbr\u003EС осторожностью: Проведение десенсибилизирующей терапии; стенокардия Принцметала; гипертиреоз; сахарный диабет 1 типа и сахарный диабет со значительными колебаниями концентрации глюкозы в крови; AV блокада I степени; выраженная почечная недостаточность (клиренс креатинина менее 20 мл/мин); выраженные нарушения функции печени; псориаз; рестриктивная кардиомиопатия; врожденные пороки сердца или порок клапана сердца с выраженными гемодинамическими нарушениями; хроническая сердечная недостаточность с инфарктом миокарда в течение последних 3 месяцев; феохромоцитома (при сопутствующем применении альфа-адреноблокаторов); строгая диета."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Нерекомендуемые комбинации\u003Cbr\u003EПри лечении хронической сердечной недостаточности:\u003Cbr\u003EАнтиаритмические средства I класса (например, хинидин, дизопирамид, лидокаин, фенитоин; флекаинид, пропафенон) при одновременном применении с бисопрололом могут снижать AV проводимость и сократительную способность сердца.\u003Cbr\u003EПри лечении хронической сердечной недостаточности, артериальной гипертензии: стабильной стенокардии:\u003Cbr\u003EБлокаторы \"медленных\" кальциевых каналов (БМКК) типа верапамила и в меньшей степени, дилтиазема, при одновременном применении с бисопрололом могут приводить к снижению сократительной способности миокарда и нарушению AV проводимости. В частности, внутривенное введение верапамила пациентам, принимающим бета-адреноблокаторы, может привести к выраженной артериальной гипотензии и AV блокаде.\u003Cbr\u003EГипотензивные средства центрального действия (такие, как клонидин, метилдопа, моксонидин, рилменидин) могут привести к урежению ЧСС и снижению сердечного выброса, а также к вазодилатации вследствие снижения центрального симпатического тонуса. 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На коже лица чаще, чем на других поверхностях тела, после длительного лечения глюкокортикостероидами местного действия могут проявляться атрофические изменения; курс лечения в этом случае не должен превышать 5 дней.\u003Cbr\u003EНеобходимо соблюдать осторожность при нанесении препарата на лицо, складки, область естественных сгибов, на участки с тонкой кожей. Не наносить препарат на слизистые оболочки.\u003Cbr\u003EСледует учитывать, что глюкокортикостероиды способны изменять проявления некоторых заболеваний кожи, что может затруднить постановку диагноза. Кроме того, применение глюкокортикостероидов может быть причиной задержки заживления ран.\u003Cbr\u003EПри длительной терапии глюкокортикостероидами внезапное прекращение терапии может привести к развитию \"синдрома рикошета\", проявляющего в форме дерматита с интенсивным покраснением кожи и ощущением жжения. 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Германия","filterIds":["16064056"],"filters":[{"id":16064056,"name":"","values":[{"value":"16064114","isFilterable":true,"text":""}],"type":"","subType":"","unit":""}]}],"full":[{"name":"Общие характеристики","specs":[{"description":"","filters":[{"id":34324371,"name":"Тип препарата"}],"isMainProperty":false,"name":"Тип препарата","value":"лекарственный препарат"},{"description":"","filters":[{"id":27272850,"name":"Рецептурный препарат"}],"isMainProperty":false,"name":"Рецептурный препарат","value":"да"},{"description":"","filters":[{"id":34045610,"name":"Органы и системы"}],"isMainProperty":false,"name":"Органы и системы","value":"выделительная система, половая система, половые железы"},{"description":"","filters":[{"id":36476390,"name":"Назначение"}],"isMainProperty":false,"name":"Назначение","value":"доброкачественная гиперплазия предстательной железы, учащенное мочеиспускание"},{"description":"","filters":[{"id":15768013,"name":"Показания к применению"}],"isMainProperty":false,"name":"Показания к применению","value":"Лечение дизурических расстройств при доброкачественной гиперплазии предстательной железы (ДГПЖ)."},{"description":"","filters":[{"id":15768002,"name":"Противопоказания"}],"isMainProperty":false,"name":"Противопоказания","value":"- Гиперчувствительность к тамсулозину (в том числе, наличие лекарственного ангионевротического отека в анамнезе) или к любому из вспомогательных веществ, (см. раздел «Состав»);\u003Cbr\u003E\n- ортостатическая гипотензия (в т.ч., в анамнезе);\u003Cbr\u003E\n- печеночная недостаточность тяжелой степени; возраст до 18 лет.\u003Cbr\u003E"},{"description":"","filters":[{"id":15768292,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"1 капсула содержит (пеллеты, покрытые кишечнорастворимой оболочкой)\u003Cbr\u003E\nЯдро:\u003Cbr\u003E\nДействующее вещество: тамсулозина гидрохлорид - 0,4 мг;\u003Cbr\u003E\nВспомогательные вещества: целлюлоза микрокристаллическая (тип 101), метакриловой кислоты и этилакрилата сополимер (1:1), дисперсия 30 %, триэтилцитрат, тальк.\u003Cbr\u003E\nОболочка: метакриловой кислоты и этилакрилата сополимер (1:1), дисперсия тальк, триэтилцитрат.\u003Cbr\u003E\nКапсула\u003Cbr\u003E\nКорпус капсулы: краситель железа оксид красный (Е 172), титана диоксид (Е 171), краситель железа оксид желтый (Е 172), желатин.\u003Cbr\u003E\nКрышечка капсулы: индигокармин (Е 132), краситель железа оксид черный (Е 172), титана диоксид (Е 171), краситель железа оксид желтый (Е 172), желатин."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Taмcyлoзин"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Внутрь, по 1 капсуле 1 раз в сутки после завтрака или первого приема пищи. Капсулу следует проглатывать целиком, не разжевывая, запивая достаточным количеством воды. Капсулу нельзя делить на части или разламывать, так как это может повлиять на скорость высвобождения действующего вещества.\u003Cbr\u003E\nУчитывая прогрессирующий характер заболевания, симптоматическая терапия может проводиться длительно. Длительность лечения определяет врач.\u003Cbr\u003E\nПрименение препарата в особых клинических группах пациентов\u003Cbr\u003E\nПожилые пациенты\u003Cbr\u003E\nКоррекции дозы тамсулозина не требуется.\u003Cbr\u003E\nДети и подростки до 18 лет\u003Cbr\u003E\nТамсулозин не показан к применению у детей и подростков до 18 лет.\u003Cbr\u003E\nУ пациентов с нарушением функции почек\u003Cbr\u003E\nУ пациентов с почечной недостаточностью коррекции дозы не требуется. Применение тамсулозина у пациентов с терминальной стадией почечной недостаточности (клиренс\nкреатинина \u003C10 мл/мин) требует соблюдения мер предосторожности и тщательного врачебного наблюдения.\u003Cbr\u003E\nУ пациентов с нарушением функции печени\u003Cbr\u003E\nПри печеночной недостаточности легкой и средней степени тяжести, коррекции режима дозирования препарата не требуется. Применение тамсулозина при печеночной недостаточности тяжелой степени противопоказано."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Возможные побочные эффекты при применении препарата приведены ниже по нисходящей частоте возникновения: часто (\u003C 1/10, ≥1/100), нечасто (\u003C 1/100, ≥ 1/1000), редко (\u003C 1/1000, ≥ 1/10000), очень редко (\u003C 1/10000), частота неизвестна (по имеющимся данным установить частоту не представляется возможным), включая отдельные сообщения.\u003Cbr\u003E\nНарушения со стороны нервной системы: часто - головокружение; нечасто - головная боль; редко - обморочные состояния.\u003Cbr\u003E\nНарушения со стороны органа зрения: частота неизвестна: - нечеткость зрения, нарушения зрения.\u003Cbr\u003E\nНарушения со стороны сердца: нечасто - \"ощущение сердцебиения\".\u003Cbr\u003E\nНарушения со стороны сосудов: нечасто - ортостатическая гипотензия.\u003Cbr\u003E\nНарушения со стороны дыхательной системы, грудной клетки и органов средостения: нечасто - ринит; частота неизвестна - эпистаксис (носовое кровотечение).\u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта: нечасто - запор, диарея, тошнота, рвота; частота неизвестна - сухость во рту.\u003Cbr\u003E\nНарушения со стороны половых органов и грудной железы: часто - нарушения эякуляции, ретроградная эякуляция, анэякуляция; очень редко - приапизм.\u003Cbr\u003E\nНарушения co стороны кожи и подкожных тканей: нечасто - сыпь, кожный зуд, крапивница; редко - ангионевротический отек; очень редко - синдром Стивенса-Джонсона; частота неизвестна - многоформная эритема, эксфолиативный дерматит. Общие нарушения: нечасто - астения.\u003Cbr\u003E\nВ ходе пострегистрационных наблюдений были зарегистрированы случаи развития синдрома интраоперационной нестабильности радужной оболочки глаза (синдром \"узкого зрачка\") при операции по поводу катаракты или глаукомы у пациентов, принимавших тамсулозин.\u003Cbr\u003E\nОпыт пострегистрационного применения: в дополнение к перечисленным выше нежелательным реакциям на фоне применения тамсулозина были зарегистрированы отдельные случаи фибрилляции предсердий, нарушения ритма сердца, тахикардии и диспноэ. В связи с тем, что данные были получены методом спонтанных сообщений в пострегистрационный период применения тамсулозина, не представляется возможным с достаточной степенью надежности оценить частоту развития данных нежелательных реакций и их связь с терапией тамсулозином.\u003Cbr\u003E"},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Тамсулозин является специфическим блокатором постсинаптических α1-адренорецепторов, находящихся в гладкой мускулатуре предстательной железы, шейки мочевого пузыря и простатической части уретры. Блокада α1-адренорецепторов тамсулозином приводит к снижению тонуса гладкой мускулатуры предстательной железы, шейки мочевого пузыря и простатической части уретры и улучшению оттока мочи. Одновременно уменьшаются как симптомы опорожнения, так и симптомы наполнения мочевого пузыря, обусловленные повышенным тонусом гладкой мускулатуры и детрузорной гиперактивностью при доброкачественной гиперплазии предстательной железы. Такой фармакологический эффект сохраняется в течение длительного времени. Также существенно снижается необходимость в оперативном вмешательстве или катетеризации.\u003Cbr\u003E\nСпособность тамсулозина воздействовать на α1A подтип адренорецепторов в 20 раз превосходит его способность взаимодействовать с α1B подтипом адренорецепторов, расположенных в гладких мышцах сосудов. Благодаря своей высокой селективности, тамсулозин не вызывает клинически значимого снижения системного артериального давления как у пациентов с артериальной гипертензией, так и у пациентов с нормальным исходным уровнем артериального давления.\u003Cbr\u003E"},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"альфа1-адреноблокатор"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"капсулы"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":14805991,"name":"Пол"}],"isMainProperty":false,"name":"Пол","value":"для мужчин"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Хранить при температуре не выше 25°С. Хранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Симптомы\u003Cbr\u003E\nНет сообщений о случаях острой передозировки тамсулозином. Передозировка тамсулозина может вызвать серьезное снижение артериального давления и\nкомпенсаторную тахикардию.\u003Cbr\u003E\nЛечение\u003Cbr\u003E\nПри передозировке лечение симптоматическое. Артериальное давление и частота\nсердечных сокращений могут восстановиться при принятии человеком горизонтального\nположения. При отсутствии эффекта можно применить средства, увеличивающие объем\nциркулирующей крови и, если необходимо, сосудосуживающие средства. Необходимо\nконтролировать функцию почек. Проведение гемодиализа нецелесообразно, так как\nтамсулозин активно связывается с белками плазмы. Для предотвращения дальнейшего\nвсасывания препарата целесообразно промывание желудка, прием активированного угля\nили осмотического слабительного, например, магния сульфата."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Препарат Профлосин предназначен для применения только у мужчин."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Исследований по влиянию тамсулозина на способность к управлению транспортными средствами и механизмами не проводилось. Но, учитывая возможность возникновения головокружения, необходимо соблюдать осторожность при управлении транспортными средствами и другими механизмами, а также при занятиях другими потенциально опасными видами деятельности."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"С осторожностью\u003Cbr\u003E\n- почечная недостаточность в терминальной стадии (клиренс креатинина менее 10 мл/мин);\u003Cbr\u003E\n- при одновременном применении с сильными, и средней активности ингибиторами изофермента CYP3A4;\u003Cbr\u003E\n- артериальная гипотензия."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Тамсулозин не взаимодействует с атенололом, эналаприлом и теофиллином. При одновременном применении с циметидином отмечено некоторое повышение концентрации тамсулозина в плазме крови; с фуросемидом - снижение концентрации тамсулозина в плазме крови, однако это не требует коррекции дозы препарата, поскольку концентрация тамсулозина остается в пределах нормального диапазона. Диклофенак и варфарин могут увеличивать скорость выведения тамсулозина.\u003Cbr\u003E\nIn vitro диазепам, пропранолол, трихлорметиазид, хлормадинон, амитриптилин, диклофенак, глибенкламид, симвастатин, варфарин не влияли на свободную фракцию тамсулозина в плазме крови человека. В свою очередь тамсулозин не изменял свободные фракции диазепама, пропранолола, трихлорметиазида и хлормадинона.\u003Cbr\u003E\nОдновременное применение тамсулозина с сильными ингибиторами изофермента CYP3A4 может приводить к увеличению концентрации тамсулозина в плазме крови. Одновременное применение с кетоконазолом (сильный ингибитор изофермента CYP3A4) приводило к увеличению AUC и Сmах тамсулозина в 2,8 и 2,2 раза, соответственно.\u003Cbr\u003E\nТамсулозин не следует назначать одновременно с сильными ингибиторами изофермента CYP3A4 пациентам с нарушением метаболизма изофермента CYP2D6.\u003Cbr\u003E\nТамсулозин следует применять с осторожностью одновременно с сильными и средней активности ингибиторами изофермента CYP3A4.\u003Cbr\u003E\nОдновременное применение тамсулозина с пароксетином, сильным ингибитором изофермента CYP2D6, приводило к увеличению Сmах и AUC тамсулозина в 1,3 и 1,6 раз, соответственно, однако данные изменения не имели клинической значимости.\u003Cbr\u003E\nОдновременное применение тамсулозина с другими блокаторами (a1-адренорецепторов, ингибиторами холинэстеразы, алпростадилом. анестетиками, диуретиками, леводопой, миорелаксантами, нитратами, антидепрессантами, бета-адреноблокаторами, блокаторами \"медленных\" кальциевых каналов, этанолом может приводить к выраженному снижению артериального давления."},{"description":"","filters":[{"id":50164710,"name":"Источник"}],"isMainProperty":false,"name":"Источник","value":"\u003Ca href=\"https://www.vidal.ru\" target=\"_blank\"\u003EСправочник лекарственных препаратов Видаль<\u002Fa\u003E"},{"description":"","filters":[{"id":16435314,"name":"Регистрационный номер"}],"isMainProperty":false,"name":"Регистрационный номер","value":"ЛП-№(001222)-(РГ-RU)"},{"description":"","filters":[{"id":16435315,"name":"Дата государственной регистрации"}],"isMainProperty":false,"name":"Дата государственной регистрации","value":"16.09.2022"},{"description":"","filters":[{"id":34324371,"name":"Тип препарата"},{"id":7893318,"name":"Производитель"}],"isMainProperty":false,"name":"Владелец регистрационного удостоверения","value":"Берлин-Фарма"},{"description":"","filters":[{"id":35771390,"name":"Изготовитель"}],"isMainProperty":false,"name":"Изготовитель","value":"Лабораториос Менарини 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